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Roxee Meds Catalog

Lotilaner

Medication catalog facts with explicit FDA-approval, off-label, source-limited, and safety context.

Both Catalog complete FDA data linked Rx required Chewable Tablets Elanco US Inc. Official label facts Owner quick guide first
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Data freshness

Storefront facts
Catalog refreshed
May 5, 2026, 10:00 a.m.

These are the storefront facts Roxee uses on browse cards and quick facts.

FDA applications
FDA application data refreshed
May 5, 2026, 10:00 a.m.

Sponsor, product, and application records imported from Animal Drugs @ FDA.

Safety reports
Safety data refreshed
May 5, 2026, 10:01 a.m.

openFDA reaction terms and case summaries are supporting evidence, not proof of causality.

Source timing details
Source timing details
  • Storefront facts: Source Roxee | Refreshed May 5, 2026, 10:00 AM UTC
    The storefront fact projection used for browse cards and quick facts.
  • Animal Drugs @ FDA: Source FDA | Refreshed May 5, 2026, 10:00 AM UTC
    Applications/products are imported from FDA export data.
  • Animal Drugs @ FDA previews: Source FDA | Refreshed Feb 9, 2026, 3:05 AM UTC
    Label highlights/doc links are fetched from FDA preview endpoints.
  • Animal Drug Product Listing Directory (NDC): Source FDA | Refreshed May 5, 2026, 10:00 AM UTC
    Package/product NDCs from FDA’s electronic listing directory (XLS).
  • openFDA reaction terms: Source FDA openFDA | Refreshed May 5, 2026, 10:04 AM UTC
  • openFDA case summaries: Source FDA openFDA | Refreshed May 5, 2026, 10:04 AM UTC

Evidence

Reviewed / Updated / Sources

Reviewed by: Not available

Last reviewed: February 12, 2026

Updated: February 12, 2026, 10:44 PM UTC

Sources:
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Lotilaner

Lotilaner

Drug type: Generic ingredient • Branded profile • FDA branded products available

Both Chewable Tablets Rx required 100% storefront ready

Species: Both

Manufacturer: Elanco US Inc.

Medication Snapshot

Merged from the current Roxee medication system with field-level provenance, freshness, and completeness tracking.

Lotilaner

For the treatment of infestations caused by New World screwworm ( Cochliomyia hominivorax ) larvae (myiasis) in dogs and puppies. For the treatment of infestations caused by New World screwworm ( Cochliomyia hominivorax ) larvae (myiasis) in cats and kittens. Credelio™ kills adult fleas and is indicated for the treatment and prevention of flea infestations ( Ctenocephalides felis ) and the treatment and control of tick infestations [ Amblyomma americanum (lone star tick), Dermacentor variabilis (American dog tick), Ixodes scapularis (black-legged tick), Rhipicephalus sanguineus (brown dog tick), and Haemaphysalis longicornis (longhorned tick)] for one month in dogs and puppies 8 weeks of age and older, and weighing 4.4 pounds or greater. Credelio™ is indicated for the prevention of Borrelia burgdorferi infections as a direct result of killing Ixodes scapularis vector ticks. Species commonly shown: Both, Dog, No Use Class Stated Or Implied, Cat, No Use Class Stated Or Implied.

Generic name
Lotilaner
Brand names
Credelio™, Credelio™ CAT, Credelio
Manufacturer
Elanco US Inc.
Species
Both, Dog, No Use Class Stated Or Implied, Cat, No Use Class Stated Or Implied
Dosage forms
Chewable Tablets
Prescription
Prescription required
Completeness
100%
Validation
Complete
Brand names
Credelio™ Credelio™ CAT Credelio
Dosage forms
Chewable Tablets

Indications / Uses

For the treatment of infestations caused by New World screwworm ( Cochliomyia hominivorax ) larvae (myiasis) in dogs and puppies. For the treatment of infestations caused by New World screwworm ( Cochliomyia hominivorax ) larvae (myiasis) in cats and kittens. Credelio™ kills adult fleas and is indicated for the treatment and prevention of flea infestations ( Ctenocephalides felis ) and the treatment and control of tick infestations [ Amblyomma americanum (lone star tick), Dermacentor variabilis (American dog tick), Ixodes scapularis (black-legged tick), Rhipicephalus sanguineus (brown dog tick), and Haemaphysalis longicornis (longhorned tick)] for one month in dogs and puppies 8 weeks of age and older, and weighing 4.4 pounds or greater. Credelio™ is indicated for the prevention of Borrelia burgdorferi infections as a direct result of killing Ixodes scapularis vector ticks.

Side Effects

Top reported reactions (openFDA): Vomiting, Diarrhoea, Lack of efficacy (ectoparasite) - tick NOS, Other abnormal test result NOS, Lethargy (see also Central nervous system depression in 'Neurological'), Seizure NOS.

FAQ

Both, Dog, No Use Class Stated Or Implied, Cat, No Use Class Stated Or Implied

Yes. Roxee shows this as prescription-only.

Chewable Tablets

Related Medications

Afoxolaner Same category: Flea & Tick Doxycycline Same category: Flea & Tick Fluralaner 13.64% 12-Week Chew Same category: Flea & Tick Fluralaner Chew Tablets Same category: Flea & Tick Fluralaner Spot-On Solution Same category: Flea & Tick Imidacloprid Same category: Flea & Tick

Related Conditions

Fleas (Flea Infestation) Myiasis (fly strike) Tick infestation

Source Transparency

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Pet Owner Quick Guide

Start here first for the safest next-step summary before the deeper medication detail.

Used for:

For the treatment of infestations caused by New World screwworm ( Cochliomyia hominivorax ) larvae (myiasis) in dogs and puppies.

Dosing note:

Exact dosing depends on your pet's species, weight, and health status. Use your veterinarian's instructions for the exact dose and schedule.

What to watch for:

  • Hyperglycaemia (1 reports)
  • Hiding (1 reports)
  • Haematuria (1 reports)

When to call the vet:

  • Repeated vomiting or diarrhea.
  • Severe lethargy (hard to wake, very low energy).
  • Collapse or fainting.
  • Trouble breathing.
  • Facial swelling or hives.
  • Blood in vomit or stool.

What to tell or ask your vet today:

  • Is this medicine the right fit for my pet’s current symptoms?
  • Which warning signs mean I should call back right away?
  • How should I handle missed doses or refusal to take the medicine?
Major cautions & emergency warning signs

Side effects to monitor:

  • Hyperglycaemia
  • Hiding
  • Haematuria

Most reported reactions:

  • Hyperglycaemia (1 reports)
  • Hiding (1 reports)
  • Haematuria (1 reports)

Emergency warning signs:

  • Repeated vomiting or diarrhea.
  • Severe lethargy (hard to wake, very low energy).
  • Collapse or fainting.
  • Trouble breathing.
Talk to a Vet / Find a Vet Near You Start Symptom Intake

Quick Facts

Official label facts first, then secondary summaries. Marketing content is separated below.

Species: Both
Manufacturer: Elanco US Inc.
Form: Chewable Tablets
Identifiers:
NADA: 141494 NADA: 141528 NADA: 141581 NADA: 141619 NADA: 6662 NADA: 6664 NDC Package: 58198-5451-1 NDC Package: 58198-5451-2 NDC Package: 58198-5451-3 NDC Package: 58198-5451-4 NDC Package: 58198-5451-6 NDC Package: 58198-5451-7 NDC Package: 58198-5452-1 NDC Package: 58198-5452-2 NDC Package: 58198-5452-3 NDC Package: 58198-5452-4 NDC Package: 58198-5452-5 NDC Package: 58198-5452-6 NDC Package: 58198-5452-7 NDC Package: 58198-5454-1
Source metadata:

Adverse Reactions

Snapshot first, detailed rows second. This section summarizes signal data and is not a diagnosis.

Tap or hover a reaction to see what it means in plain language.

Tracked signals
32
Reported cases
32
Serious reports
20
Species represented
2
Grouped by Body System
Digestive (4) · Vomiting, Diarrhea, Decreased appetite Skin & allergy (2) · Hair loss, Face and neck swelling Behavior (2) · Biting -aggression, Behavioral disorder (unspecified) Other (24) · Hyperglycaemia, Hiding, Haematuria
Most Reported Reactions
Reaction Body system Cases Species Serious cases
Other 1 Cat 1
Other 1 Cat 1
Other 1 Cat 1
Other 1 Cat 1
Other 1 Cat 1
Other 1 Dog 1
Other 1 Cat 1
Skin & allergy 1 Dog 1

Species coverage: Cat (17) Dog (15)

View detailed reaction table
Reaction Body system Species Seriousness Frequency Reports
Digestive Dog Non-serious - 1
Other Cat Serious - 1
Other Cat Serious - 1
Skin & allergy Dog Non-serious - 1
Other Cat Serious - 1
Other Cat Serious - 1
Other Cat Serious - 1
Other Dog Serious - 1
Other Cat Serious - 1
Skin & allergy Dog Serious - 1
Other Cat Serious - 1
Other Dog Non-serious - 1
Other Cat Serious - 1
Other Cat Serious - 1
Other Cat Serious - 1
Other Cat Serious - 1
Digestive Cat Serious - 1
Digestive Dog Non-serious - 1
Other Cat Serious - 1
Other Dog Non-serious - 1
Other Dog Non-serious - 1
Other Dog Non-serious - 1
Other Dog Serious - 1
Other Dog Non-serious - 1
Other Cat Serious - 1
Digestive Dog Non-serious - 1
Behavior Dog Serious - 1
Other Cat Serious - 1
Behavior Dog Non-serious - 1
Other Dog Non-serious - 1
Other Cat Non-serious - 1
Other Cat Serious - 1
Source metadata:

Documents

Owner handouts and official technical documents open on-page first, with the original source still one click away.

Owner handouts

0
No owner handouts linked yet.

Official label / PI

0
No official label or package insert links yet.

SPL

7

FOI

11

Credelio™

SPL · SPL

Open original
FDA Structured Product Label

Credelio™

Rendered from Roxee's cached FDA SPL package contents for on-page reading. Use Open original for the raw FDA ZIP/XML source.

Sponsor
Elanco US Inc.
E
6662
Status
RX
Form
Chewable Tablets
Route
Oral
Composition / specifications
Each chewable tablet contains 56.25 mg, 112.5 mg, 225 mg, 450 mg, or 900 mg lotilaner

Dogs

Indication

For the treatment of infestations caused by New World screwworm (Cochliomyia hominivorax) larvae (myiasis) in dogs and puppies.

Dosage

Administer orally at the minimum dosage of 9 mg/lb (20 mg/kg) with food.

Credelio™ CAT

SPL · SPL

Open original
FDA Structured Product Label

Credelio™ CAT

Rendered from Roxee's cached FDA SPL package contents for on-page reading. Use Open original for the raw FDA ZIP/XML source.

Sponsor
Elanco US Inc.
E
6664
Status
RX
Form
Chewable Tablets
Route
Oral
Composition / specifications
Each chewable tablet contains 12 mg or 48 mg lotilaner

Cats

Indication

For the treatment of infestations caused by New World screwworm (Cochliomyia hominivorax) larvae (myiasis) in cats and kittens.

Dosage

Administer orally at the minimum dosage of 2.7 mg/lb (6 mg/kg) with food.

Credelio™

SPL · SPL

Open original
FDA Structured Product Label

Credelio™

Rendered from Roxee's cached FDA SPL package contents for on-page reading. Use Open original for the raw FDA ZIP/XML source.

Sponsor
Elanco US Inc.
NADA
141-494
Status
RX
Form
Chewable Tablets
Route
Oral
Species
Dog, No Use Class Stated Or Implied
Composition / specifications
Each chewable tablet contains 56.25 mg, 112.5 mg, 225 mg, 450 mg, or 900 mg lotilaner.

Dogs

Indication

Credelio™ kills adult fleas and is indicated for the treatment and prevention of flea infestations (Ctenocephalides felis) and the treatment and control of tick infestations [Amblyomma americanum (lone star tick), Dermacentor variabilis (American dog tick), Ixodes scapularis (black-legged tick), Rhipicephalus sanguineus (brown dog tick), and Haemaphysalis longicornis (longhorned tick)] for one month in dogs and puppies 8 weeks of age and older, and weighing 4.4 pounds or greater. Credelio™ is indicated for the prevention of Borrelia burgdorferi infections as a direct result of killing Ixodes scapularis vector ticks.

Dosage

Credelio™ chewable tablets are given orally once a month at the recommended minimum dosage of 9 mg/lb (20 mg/kg). Credelio™ must be administered with food.

Credelio™ CAT

SPL · SPL

Open original
FDA Structured Product Label

Credelio™ CAT

Rendered from Roxee's cached FDA SPL package contents for on-page reading. Use Open original for the raw FDA ZIP/XML source.

Sponsor
Elanco US Inc.
NADA
141-528
Status
RX
Form
Chewable Tablets
Route
Oral
Species
Cat, No Use Class Stated Or Implied
Composition / specifications
Each chewable tablet contains 12 mg or 48 mg lotilaner.

Cats

Indication

Kills adult fleas, and is indicated for the treatment and prevention of flea infestations (Ctenocephalides felis) for one month in cats and kittens 8 weeks of age and older and weighing 2.0 pounds or greater. It also indicated for the treatment and control of Ixodes scapularis (black-legged tick) infestations for one month in cats and kittens 6 months of age and older, and weighing 2.0 pounds or greater.

Dosage

Administer orally once a month at the minimum dosage of 2.7 mg/lb (6 mg/kg). Must be administered with food.

Credelio SPL

SPL · Structured Product Label

Open original
FDA Structured Product Label XML for Credelio. Use the source link for the full official labeling record.

Credelio SPL

SPL · Structured Product Label

Open original
FDA Structured Product Label XML for Credelio. Use the source link for the full official labeling record.

Credelio SPL

SPL · Structured Product Label

Open original
FDA Structured Product Label XML for Credelio. Use the source link for the full official labeling record.

FOI Summary oV 006-662 Authorized October 24, 2025.pdf

FOI · FOI

Open original

FOI oV 006-664 Authorized November 21, 2025.pdf

FOI · FOI

Open original

FOI Summary sN 141-494 Approved October 24, 2025.pdf

FOI · FOI

Open original

FOI Summary sN 141-494 Approved September 3, 2019.pdf

FOI · FOI

Open original

FOI Summary oN 141-494 Approved January 19, 2017.pdf

FOI · FOI

Open original

FOI Summary sN 141-528 Approved April 12, 2021.pdf

FOI · FOI

Open original

FOI Summary oN 141-528 Approved December 9, 2019.pdf

FOI · FOI

Open original

FOI Summary oN 141-581 Approved October 7, 2024.pdf

FOI · FOI summary

Open original

FOI Summary sN 141-581 Approved May 21, 2025.pdf

FOI · FOI summary

Open original

FOI Summary sN 141-581 Approved October 20, 2025.pdf

FOI · FOI summary

Open original

FOI Summary o 141-619 Approved December 17, 2025 (2).pdf

FOI · FOI summary

Open original
Source metadata:
Veterinary reference (advanced)

Canonical medication sections are above. This legacy block remains available for deeper cross-reference without cluttering the primary workflow.

At a Glance

Quick facts and links to official labeling and safety signals.

Data freshness
  • Storefront facts: Source Roxee | Refreshed May 5, 2026, 10:00 AM UTC
    The storefront fact projection used for browse cards and quick facts.
  • Animal Drugs @ FDA: Source FDA | Refreshed May 5, 2026, 10:00 AM UTC
    Applications/products are imported from FDA export data.
  • Animal Drugs @ FDA previews: Source FDA | Refreshed Feb 9, 2026, 3:05 AM UTC
    Label highlights/doc links are fetched from FDA preview endpoints.
  • Animal Drug Product Listing Directory (NDC): Source FDA | Refreshed May 5, 2026, 10:00 AM UTC
    Package/product NDCs from FDA’s electronic listing directory (XLS).
  • openFDA reaction terms: Source FDA openFDA | Refreshed May 5, 2026, 10:04 AM UTC
  • openFDA case summaries: Source FDA openFDA | Refreshed May 5, 2026, 10:04 AM UTC
Official (FDA)
Identity: Generic ingredient • FDA branded products available
Official FDA brands: Credelio
Manufacturer mapping: Elanco US Inc.
Case-reported brands (openFDA): MSK
Catalog species: Both • FDA-labeled species: Cat, Dog
Rx/OTC: RX
Form/route: Chewable Tablets • Oral
Applications: E 6662 • E 6664 • NADA 141-494 • NADA 141-528
NDC: Packages 58198-5451-1 58198-5451-2 58198-5451-3 58198-5451-4 58198-5451-6 58198-5451-7 • Products 58198
Documents: 7 (FOI: 7) • SPL: 4 • Label highlights • Official documents
Safety (openFDA)
Top reactions: Dog 44 • Cat 45 • View
Case summaries: 24 (showing 8) • View
openFDA reports are unverified and do not prove causation.
Explore
Linked using: Fda_Label (0.95), Fda_Label (0.95), Fda_Label (0.95)
Diagnosis Codes
ICD10_CM: B74.8 ICD10_CM: B88.1
Other filariases

Counseling and Monitoring Highlights

Global Pet owner/Vet mode is controlled in the header. This section avoids duplicate in-page persona tabs.

Top reaction signals
Hyperglycaemia (1) Hiding (1) Haematuria (1) Gastric distension (1) Gall bladder & bile duct disorder NOS (1) Fracture (1) Fever (1) Face and neck swelling (1)

Identifiers & Packages

Normalized identifiers (NDC/NADA/ANADA) and package metadata from regulator listings.

Identifiers
NADA: 141494 NADA: 141528 NADA: 141581 NADA: 141619 NADA: 6662 NADA: 6664 NDC Package: 58198-5451-1 NDC Package: 58198-5451-2 NDC Package: 58198-5451-3 NDC Package: 58198-5451-4 NDC Package: 58198-5451-6 NDC Package: 58198-5451-7 NDC Package: 58198-5452-1 NDC Package: 58198-5452-2 NDC Package: 58198-5452-3 NDC Package: 58198-5452-4 NDC Package: 58198-5452-5 NDC Package: 58198-5452-6 NDC Package: 58198-5452-7 NDC Package: 58198-5454-1 NDC Package: 58198-5454-2 NDC Package: 58198-5454-3 NDC Package: 58198-5454-4 NDC Package: 58198-5454-6
Package NDC Product NDC Form / Route Status
58198-5451-1 58198 -
58198-5451-2 58198 -
58198-5451-3 58198 -
58198-5451-4 58198 -
58198-5451-6 58198 -
58198-5451-7 58198 -
58198-5452-1 58198 -
58198-5452-2 58198 -
58198-5452-3 58198 -
58198-5452-4 58198 -
58198-5452-5 58198 -
58198-5452-6 58198 -
58198-5452-7 58198 -
58198-5454-1 58198 -
58198-5454-2 58198 -
58198-5454-3 58198 -
58198-5454-4 58198 -
58198-5454-6 58198 -
58198-5454-7 58198 -
58198-5456-1 58198 -

Enriched Documents

Documents are tiered by source trust: Official, Clinical, Manufacturer, Marketing.

Data Sources & Change Log

Every non-trivial field is expected to include provenance and update timestamps.

Official 46 Clinical 1 Manufacturer 0 Marketing 0
Current Field Facts
  • side_effects: Top reported reactions (openFDA): Vomiting, Diarrhoea, Lack of efficacy (ectoparasite) - tick NOS, Other abnormal test result NOS, Lethargy (see also Central n… (Clinical, 2026-04-11)
  • indications: Credelio™ kills adult fleas and is indicated for the treatment of flea infestations (Ctenocephalides felis) and the treatment and control of tick infestations … (Official, 2026-05-05)
  • indications: Credelio™ kills adult fleas and is indicated for the treatment of flea infestations (Ctenocephalides felis) and the treatment and control of tick infestations … (Official, 2026-05-03)
  • indications: Credelio™ kills adult fleas and is indicated for the treatment of flea infestations (Ctenocephalides felis) and the treatment and control of tick infestations … (Official, 2026-05-02)
  • indications: Credelio™ kills adult fleas and is indicated for the treatment of flea infestations (Ctenocephalides felis) and the treatment and control of tick infestations … (Official, 2026-04-29)
  • indications: Credelio™ kills adult fleas and is indicated for the treatment of flea infestations (Ctenocephalides felis) and the treatment and control of tick infestations … (Official, 2026-04-28)
  • indications: Credelio™ kills adult fleas and is indicated for the treatment of flea infestations (Ctenocephalides felis) and the treatment and control of tick infestations … (Official, 2026-04-27)
  • indications: Credelio™ kills adult fleas and is indicated for the treatment of flea infestations (Ctenocephalides felis) and the treatment and control of tick infestations … (Official, 2026-04-26)
  • indications: Credelio™ kills adult fleas and is indicated for the treatment of flea infestations (Ctenocephalides felis) and the treatment and control of tick infestations … (Official, 2026-04-25)
  • indications: Credelio™ kills adult fleas and is indicated for the treatment of flea infestations (Ctenocephalides felis) and the treatment and control of tick infestations … (Official, 2026-04-22)
  • manufacturer_name: Elanco US Inc. (Official, 2026-05-05)
  • manufacturer_name: Elanco US Inc. (Official, 2026-05-03)
  • manufacturer_name: Elanco US Inc. (Official, 2026-05-02)
  • manufacturer_name: Elanco US Inc. (Official, 2026-04-29)
  • manufacturer_name: Elanco US Inc. (Official, 2026-04-28)
  • manufacturer_name: Elanco US Inc. (Official, 2026-04-27)
  • manufacturer_name: Elanco US Inc. (Official, 2026-04-26)
  • manufacturer_name: Elanco US Inc. (Official, 2026-04-25)
  • manufacturer_name: Elanco US Inc. (Official, 2026-04-22)
  • prescription_required: Rx required (Official, 2026-05-05)
Recent Revisions
  • side_effects updated 2026-04-12 10:05 by etl_backfill • Backfilled from existing medication fields
  • usage updated 2026-04-12 10:05 by etl_backfill • Backfilled from existing medication fields
  • side_effects updated 2026-04-11 10:05 by etl_backfill • Backfilled from existing medication fields
  • usage updated 2026-04-11 10:05 by etl_backfill • Backfilled from existing medication fields
  • side_effects updated 2026-02-12 22:44 by etl_backfill • Backfilled from existing medication fields
  • usage updated 2026-02-12 22:44 by etl_backfill • Backfilled from existing medication fields

FDA Products & Applications (Animal Drugs @ FDA)

Official sponsor/proprietary-name/application-status records linked by active ingredient.

Product Sponsor Application Status Published
Credelio™
RX
Lotilaner
Chewable Tablets • Oral
Label highlights
Official documents
Elanco US Inc. E 6662 G Jan 26, 2026
Credelio™ CAT
RX
Lotilaner
Chewable Tablets • Oral
Label highlights
Official documents
Elanco US Inc. E 6664 G Jan 26, 2026
Credelio™
RX
Lotilaner
Chewable Tablets • Oral
Label highlights
Official documents
Elanco US Inc. NADA 141-494 Approved Nov 3, 2025
Credelio™ CAT
RX
Lotilaner
Chewable Tablets • Oral
Label highlights
Official documents
Elanco US Inc. NADA 141-528 Approved May 3, 2021

Data source: FDA Animal Drugs @ FDA (public search export).

What It's For (FDA Label Highlights)

Extracted from FDA Animal Drugs @ FDA product labeling. Always confirm details with your veterinarian.

Composition / specifications
Each chewable tablet contains 56.25 mg, 112.5 mg, 225 mg, 450 mg, or 900 mg lotilaner
Dogs
Indication

For the treatment of infestations caused by New World screwworm (Cochliomyia hominivorax) larvae (myiasis) in dogs and puppies.

Dosage

Administer orally at the minimum dosage of 9 mg/lb (20 mg/kg) with food.

Limitations

FDA page: Open in Animal Drugs @ FDA

Composition / specifications
Each chewable tablet contains 12 mg or 48 mg lotilaner
Cats
Indication

For the treatment of infestations caused by New World screwworm (Cochliomyia hominivorax) larvae (myiasis) in cats and kittens.

Dosage

Administer orally at the minimum dosage of 2.7 mg/lb (6 mg/kg) with food.

Limitations

FDA page: Open in Animal Drugs @ FDA

Species: Dog, No Use Class Stated Or Implied
Composition / specifications
Each chewable tablet contains 56.25 mg, 112.5 mg, 225 mg, 450 mg, or 900 mg lotilaner.
Dogs
Indication

Credelio™ kills adult fleas and is indicated for the treatment and prevention of flea infestations (Ctenocephalides felis) and the treatment and control of tick infestations [Amblyomma americanum (lone star tick), Dermacentor variabilis (American dog tick), Ixodes scapularis (black-legged tick), Rhipicephalus sanguineus (brown dog tick), and Haemaphysalis longicornis (longhorned tick)] for one month in dogs and puppies 8 weeks of age and older, and weighing 4.4 pounds or greater. Credelio™ is indicated for the prevention of Borrelia burgdorferi infections as a direct result of killing Ixodes scapularis vector ticks.

Dosage

Credelio™ chewable tablets are given orally once a month at the recommended minimum dosage of 9 mg/lb (20 mg/kg). Credelio™ must be administered with food.

Limitations

FDA page: Open in Animal Drugs @ FDA

Species: Cat, No Use Class Stated Or Implied
Composition / specifications
Each chewable tablet contains 12 mg or 48 mg lotilaner.
Cats
Indication

Kills adult fleas, and is indicated for the treatment and prevention of flea infestations (Ctenocephalides felis) for one month in cats and kittens 8 weeks of age and older and weighing 2.0 pounds or greater. It also indicated for the treatment and control of Ixodes scapularis (black-legged tick) infestations for one month in cats and kittens 6 months of age and older, and weighing 2.0 pounds or greater.

Dosage

Administer orally once a month at the minimum dosage of 2.7 mg/lb (6 mg/kg). Must be administered with food.

Limitations

FDA page: Open in Animal Drugs @ FDA

Usage

For the treatment of infestations caused by New World screwworm ( Cochliomyia hominivorax ) larvae (myiasis) in dogs and puppies. For the treatment of infestations caused by New World screwworm ( Cochliomyia hominivorax ) larvae (myiasis) in cats and kittens. Credelio™ kills adult fleas and is indicated for the treatment and prevention of flea infestations ( Ctenocephalides felis ) and the treatment and control of tick infestations [ Amblyomma americanum (lone star tick), Dermacentor variabilis (American dog tick), Ixodes scapularis (black-legged tick), Rhipicephalus sanguineus (brown dog tick), and Haemaphysalis longicornis (longhorned tick)] for one month in dogs and puppies 8 weeks of age and older, and weighing 4.4 pounds or greater. Credelio™ is indicated for the prevention of Borrelia burgdorferi infections as a direct result of killing Ixodes scapularis vector ticks.

Source: FDA Animal Drugs @ FDA • Reference

Top Reported Reactions (openFDA)

De-duplicated reaction terms grouped by body system from FDA openFDA reports (not verified; does not prove causation).

Digestive
Vomiting (1) • Dog Diarrhea (1) • Cat Decreased appetite (1) • Dog Bloody diarrhoea (1) • Dog

Showing top 5 for Digestive.

Skin & allergy
Hair loss (1) • Dog Face and neck swelling (1) • Dog

Showing top 5 for Skin & allergy.

Behavior
Biting -aggression (1) • Dog Behavioral disorder (1) • Dog

Showing top 5 for Behavior.

Other
Hyperglycaemia (1) • Cat Hiding (1) • Cat Haematuria (1) • Cat Gastric distension (1) • Cat Gall bladder & bile duct disorder NOS (1) • Cat
Show more (19)
Fracture (1) • Dog Fever (1) • Cat Exudative skin condition (1) • Cat Erythema (1) • Dog Elevated creatinine (1) • Cat Elevated blood urea nitrogen (1) • Cat Distress (1) • Cat Distension of abdomen (1) • Cat Death (1) • Cat Cyst NOS (1) • Dog Cyanotic spots/blotchy skin (1) • Dog Cough (1) • Dog Conjunctivitis (1) • Dog Bumps on skin (1) • Dog Bloody stool (1) • Cat Bilirubinuria (1) • Cat Bacterial skin infection NOS (1) • Dog Agitation (1) • Cat Abnormal radiograph finding (1) • Cat

Showing top 5 for Other.

Data source: FDA openFDA Animal & Veterinary adverse event reports.

Adverse Event Case Summaries (openFDA)

These are individual FDA adverse event reports. They are unverified and do not prove the medication caused the reaction.

Cat, Domestic Longhair, Male, 2 year, 5.44 kilogram • Drug: MSK, Tablet, chewable, Oral, Dose: 1 tablet per animal • Reactions: Scratching, Behavioral disorder (unspecified), Shivering, Trembling, Neurological disorder NOS • Outcome: Recovered/Normal

  • Report ID: USA-USFDACVM-2025-US-075230
  • Serious AE: No
  • Treated For AE: No
  • Sex: Male
  • Age: 2.00 Year
  • Weight: 5.440 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Oral
  • Form: Tablet, chewable
  • Dose: 1 tablet per animal
Reactions Reported:
Scratching Behavioral disorder (unspecified) Shivering Trembling Neurological disorder NOS
Outcomes: Recovered/Normal

Dog, ['Spaniel - Cocker American', 'Poodle (unspecified)'], Male, 7.3 year, 9.29 kilogram • Drug: MSK, Tablet, chewable, Oral, Dose: 1 tablet per animal, Frequency: 1 per month • Reactions: Lack of efficacy (endoparasite) - roundworm NOS • Outcome: Outcome Unknown

  • Report ID: USA-USFDACVM-2025-US-075045
  • Serious AE: No
  • Treated For AE: Yes
  • Sex: Male
  • Age: 7.30 Year
  • Weight: 9.290 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Oral
  • Form: Tablet, chewable
  • Dose: 1 tablet per animal
  • Frequency: 1 per month
Reactions Reported:
Lack of efficacy (endoparasite) - roundworm NOS
Outcomes: Outcome Unknown

Dog, Weimaraner, Female, 7 year, 52.2 kilogram • Drug: MSK, Tablet, chewable, Oral, Dose: 1 tablet per animal, Frequency: 1 per month • Reactions: Lack of efficacy (bacteria) - Anaplasma, Other abnormal test result NOS • Outcome: Outcome Unknown

  • Report ID: USA-USFDACVM-2025-US-075232
  • Serious AE: No
  • Treated For AE: No
  • Sex: Female
  • Age: 7.00 Year
  • Weight: 52.200 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Oral
  • Form: Tablet, chewable
  • Dose: 1 tablet per animal
  • Frequency: 1 per month
Reactions Reported:
Lack of efficacy (bacteria) - Anaplasma Other abnormal test result NOS
Outcomes: Outcome Unknown

Cat, Domestic Shorthair, Male, 24 week, 4.71 kilogram • Drug: MSK, Tablet, chewable, Oral, Dose: 1 tablet per animal • Reactions: Lack of efficacy (endoparasite) - tapeworm, Nasal discharge, Lack of efficacy (ectoparasite) - flea • Outcome: Outcome Unknown

  • Report ID: USA-USFDACVM-2025-US-075058
  • Serious AE: No
  • Treated For AE: No
  • Sex: Male
  • Age: 24.00 Week
  • Weight: 4.710 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Oral
  • Form: Tablet, chewable
  • Dose: 1 tablet per animal
Reactions Reported:
Lack of efficacy (endoparasite) - tapeworm Nasal discharge Lack of efficacy (ectoparasite) - flea
Outcomes: Outcome Unknown

Dog, Dachshund - Miniature, Male, 3 year, 5.89 kilogram • Drug: MSK, Tablet, chewable, Oral, Dose: 1 tablet per animal • Reactions: Diarrhea, Vomiting, Unwell • Outcome: Recovered/Normal

  • Report ID: USA-USFDACVM-2025-US-074909
  • Serious AE: No
  • Treated For AE: No
  • Sex: Male
  • Age: 3.00 Year
  • Weight: 5.890 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Oral
  • Form: Tablet, chewable
  • Dose: 1 tablet per animal
Reactions Reported:
Diarrhea Vomiting Unwell
Outcomes: Recovered/Normal

Dog, Shepherd Dog - Australian, Female, 2 year, 19.95 kilogram • Drug: MSK, Tablet, chewable, Oral, Dose: 1 tablet per animal • Reactions: Vomiting • Outcome: Recovered/Normal

  • Report ID: USA-USFDACVM-2025-US-074902
  • Serious AE: No
  • Treated For AE: No
  • Sex: Female
  • Age: 2.00 Year
  • Weight: 19.950 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Oral
  • Form: Tablet, chewable
  • Dose: 1 tablet per animal
Reactions Reported:
Vomiting
Outcomes: Recovered/Normal

Dog, Black Mouth Cur, Male, 2 year, 28 kilogram • Drug: MSK, Tablet, chewable, Oral, Dose: 1 dose per animal • Reactions: Lack of efficacy (endoparasite) - hookworm, Lack of efficacy (endoparasite) - roundworm NOS, Other abnormal test result NOS • Outcome: Outcome Unknown

  • Report ID: USA-USFDACVM-2025-US-075052
  • Serious AE: No
  • Treated For AE: Yes
  • Sex: Male
  • Age: 2.00 Year
  • Weight: 28.000 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Oral
  • Form: Tablet, chewable
  • Dose: 1 dose per animal
Reactions Reported:
Lack of efficacy (endoparasite) - hookworm Lack of efficacy (endoparasite) - roundworm NOS Other abnormal test result NOS
Outcomes: Outcome Unknown

Cat, Domestic Shorthair, Female, 15 year, 4.53 kilogram • Drug: MSK, Tablet, chewable, Oral, Dose: 1 tablet per animal, Frequency: 1 per day • Reactions: Tiredness (lethargy) • Outcome: Ongoing

  • Report ID: USA-USFDACVM-2025-US-074777
  • Serious AE: No
  • Treated For AE: No
  • Sex: Female
  • Age: 15.00 Year
  • Weight: 4.530 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Oral
  • Form: Tablet, chewable
  • Dose: 1 tablet per animal
  • Frequency: 1 per day
Reactions Reported:
Tiredness (lethargy)
Outcomes: Ongoing

Data source: FDA openFDA Animal & Veterinary adverse event reports.

Overdose Information

No approved overdose-management text is linked yet. If overdose is suspected, contact a veterinarian or emergency clinic immediately.

Storage & Handling

No approved storage guidance is linked yet for this ingredient. Use manufacturer packaging and veterinary guidance for handling/storage.

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