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Roxee Medication Guide

Metronidazole

Medication reference facts with explicit FDA-approval, off-label, source-limited, and safety context. Roxee does not sell, prescribe, or dispense medications.

Both Reference complete FDA data linked Rx required Suspension Multiple FDA labelers Official label facts Owner quick guide first
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Data freshness

Reference facts
Reference refreshed
Aug 6, 2026, 7:47 p.m.

These are the reference facts Roxee uses on browse cards and quick facts.

FDA applications
FDA application data refreshed
Aug 6, 2026, 7:47 p.m.

Sponsor, product, and application records imported from Animal Drugs @ FDA.

Safety reports
Safety data refreshed
Aug 6, 2026, 7:49 p.m.

openFDA reaction terms and case summaries are supporting evidence, not proof of causality.

Source timing details
Source timing details
  • Reference facts: Source Roxee | Refreshed Aug 6, 2026, 7:47 PM UTC
    The reference fact projection used for browse cards and quick facts.
  • Animal Drugs @ FDA: Source FDA | Refreshed Aug 6, 2026, 7:46 PM UTC
    Applications/products are imported from FDA export data.
  • Animal Drugs @ FDA previews: Source FDA | Refreshed Feb 9, 2026, 3:05 AM UTC
    Label highlights/doc links are fetched from FDA preview endpoints.
  • Animal Drug Product Listing Directory (NDC): Source FDA | Refreshed Aug 6, 2026, 7:47 PM UTC
    Package/product NDCs from FDA’s electronic listing directory (XLS).
  • openFDA reaction terms: Source FDA openFDA | Refreshed Aug 6, 2026, 7:52 PM UTC
  • openFDA case summaries: Source FDA openFDA | Refreshed Aug 6, 2026, 7:52 PM UTC
Illustration placeholder
Metronidazole

Metronidazole

Drug type: Generic ingredient • Branded profile • FDA branded products available

Both Suspension Rx required 100% reference complete

Species: Both

Manufacturer: Multiple FDA labelers

Medication Snapshot

Merged from the current Roxee medication system with field-level provenance, freshness, and completeness tracking.

Metronidazole

Antibiotic/antiprotozoal used for certain GI infections and inflammation. Species commonly shown: Both, Dog.

Generic name
Metronidazole
Brand names
AYRADIA™, MetroCleanse, Metroplex, AYRADIA
Manufacturer
Multiple FDA labelers
Species
Both, Dog
Dosage forms
Suspension
Prescription
Prescription required
Completeness
100%
Validation
Complete
Brand names
AYRADIA™ MetroCleanse Metroplex AYRADIA Metronidazole
Dosage forms
Suspension

Indications / Uses

Antibiotic/antiprotozoal used for certain GI infections and inflammation.

Administration / How To Give

Oral

Storage

Store at room temperature.

Warnings / Contraindications

Use caution with liver disease. Avoid overdosing.

  • Use caution with liver disease. Avoid overdosing.

Side Effects

GI upset. High doses can cause neurologic signs (ataxia, tremors).

FAQ

Both, Dog

Yes. Roxee shows this as prescription-only.

Suspension

Store at room temperature.

Related Medications

Amoxicillin-Clavulanate Same category: Antibiotics Cefovecin Same category: Antibiotics Cephalexin Same category: Antibiotics Enrofloxacin Same category: Antibiotics Ivermectin, Pyrantel Same category: Antibiotics Melarsomine Dihydrochloride Same category: Antibiotics

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Pet Owner Quick Guide

Start here first for the safest next-step summary before the deeper medication detail.

Used for:

For the treatment of Giardia duodenalis infection in dogs.

Dosing note:

Exact dosing depends on your pet's species, weight, and health status. Use your veterinarian's instructions for the exact dose and schedule.

What to watch for:

  • Use caution with liver disease
  • Avoid overdosing
  • wobbly/unsteady walking (1 reports)
  • Loss of appetite (1 reports)
  • Death by euthanasia (1 reports)

When to call the vet:

  • Repeated vomiting or diarrhea.
  • Severe lethargy (hard to wake, very low energy).
  • Collapse or fainting.
  • Trouble breathing.
  • Facial swelling or hives.
  • Blood in vomit or stool.

What to tell or ask your vet today:

  • Is this medicine the right fit for my pet’s current symptoms?
  • Which warning signs mean I should call back right away?
  • How should I handle missed doses or refusal to take the medicine?

Next actions

Talk to a Vet / Find a Vet Near You Save to pet meds Share page Review report evidence
Research brief

Medication Research Insights

A source-aware map of what to know, what is uncertain, and what to verify with your veterinarian.

Source Backed Signals

What to know

Evidence-backed context Limited

Roxee has limited cited overview evidence for Metronidazole; use the official documents and your veterinarian's instructions for product-specific decisions.

Source: openFDA case USA-USFDACVM-2026-US-014449
Safety signal coverage Reported signals

32 tracked reaction signals; 32 reported cases; 22 serious reports; 2 species groups. These are reporting and label-derived signals for interpretation with a veterinarian.

Source: openFDA case USA-USFDACVM-2026-US-014449
Interpretation guardrail Not causation

Adverse-event reports help form a watch list, but they do not prove the medication caused the reaction and they are not a risk ranking between medications.

Evidence tension

Stronger signal Label / review

Official labels, package inserts, and reviewed summaries carry more weight than isolated reports.

Source: openFDA case USA-USFDACVM-2026-US-014449
Weaker signal Reported data

Case reports and openFDA terms are useful for pattern awareness, but they are incomplete, can include multiple exposures, and do not estimate an individual pet's probability of harm.

Reaction signal map

Most reported reactions Top terms

Unsteady walking (ataxia) (1 reports), Loss of appetite (1 reports), Death by euthanasia (1 reports), Death (1 reports), Cystitis (1 reports)

Body systems represented Signal grouping

Digestive (2), Skin & allergy (1), Neurologic (1), Behavior (2)

Explore supporting adverse reports

Species and breed lens

Species represented in reports Species lens

Dog (24 reports), Cat (8 reports)

Breed metadata in reports Metadata only

Retriever - Labrador (2), Schnauzer - Miniature (1), Setter - English (1), ['Shepherd Dog - German', 'Dog (unknown)'] (1). These are report metadata, not proof that a breed is at higher risk.

What your vet may verify

Fit for this patient Vet check

Verify whether Metronidazole fits the pet's species, current diagnosis, age, weight, organ status, pregnancy/lactation status, and concurrent medications.

Evidence limitations Evidence review

Separate label-backed warnings from adverse-event reports and owner observations before changing the plan.

What to watch next

Watch list Owner-safe

Use caution with liver disease, Avoid overdosing, wobbly/unsteady walking, Loss of appetite, Death by euthanasia

Call sooner if Escalation

Repeated vomiting or diarrhea. Severe lethargy (hard to wake, very low energy). Collapse or fainting.

Bottom line: Use this Metronidazole brief as a structured watch list and source map, not as a reason to start, stop, or change treatment without your veterinarian.
Vet source depth
  1. openFDA case USA-USFDACVM-2026-US-014449 · adverse_reaction · adverse reactions
  2. Contraindication source · fda_animal_drugs · warnings contraindications
  3. FDA application profile · official_label · quick facts
  4. Medication usage source · fda_animal_drugs · quick facts
  5. FOI · document · documents
  6. SPL · document · documents
  7. Structured Product Label · document · documents
  8. Structured Product Label · document · documents

Evidence

Review status / Updated / Sources

Review status: Clinical reviewer not listed

Updated: February 12, 2026, 7:40 PM UTC

Sources:
Safety & side effects

Side effects to monitor:

  • Use caution with liver disease
  • Avoid overdosing
  • wobbly/unsteady walking
  • Loss of appetite
  • Death by euthanasia

Most reported reactions:

  • Unsteady walking (ataxia) (1 reports)
  • Loss of appetite (1 reports)
  • Death by euthanasia (1 reports)
Explore reported case details

Emergency warning signs:

  • Repeated vomiting or diarrhea.
  • Severe lethargy (hard to wake, very low energy).
  • Collapse or fainting.
  • Trouble breathing.
Talk to a Vet / Find a Vet Near You Start Symptom Intake

Vet Fast Scan

Source-backed clinical checkpoints for quick review.

FDA-labeled species
Dog
Indication / use
For the treatment of Giardia duodenalis infection in dogs.
Form / route / dose
Form: Suspension
Route: Oral
Confirm product label and patient-specific plan.
Warnings
  • High: Use caution with liver disease. Avoid overdosing.
Adverse-event caveat
openFDA adverse-event cases are reported signals. They are not verified, do not prove causation, and do not estimate a pet's individual risk.
Source docs

Quick Facts

Official label facts first, then secondary summaries. Marketing content is separated below.

Species: Both
Manufacturer: Multiple FDA labelers
Form: Suspension
Identifiers:
NADA: 141572 NDC Package: 17163-015-16 NDC Package: 17163-016-17 NDC Package: 43457-537-25 NDC Package: 46144-602-01 NDC Package: 51311-034-10 NDC Package: 51311-034-30 NDC Package: 53745-016-01 NDC Package: 53745-016-02 NDC Package: 55999-081-12 NDC Package: 55999-081-15 NDC Package: 55999-081-18 NDC Package: 55999-081-56 NDC Package: 55999-081-57 NDC Package: 62157-529-01 NDC Package: 63732-2047-9 NDC Package: 73309-199-01 NDC Package: 86184-255-01 NDC Product: 17163 NDC Product: 43457
Source metadata:

Warnings / Contraindications

Use caution with liver disease. Avoid overdosing.

  • High: Use caution with liver disease. Avoid overdosing.
Source metadata:

Adverse Reactions

Snapshot first, detailed rows second. This section summarizes signal data and is not a diagnosis.

Reported case explorer

Filter stored openFDA reports by pet and report attributes. Counts describe reports in this data set, not risk.

Clear filters
openFDA adverse-event cases are reported signals. They are not verified, do not prove causation, and do not estimate a pet's individual risk.
Stored reports
39
Matching reports
39
Active filters
0
Reset
Drill into common report signals
Lethargy (see also Central nervous system depression in Neurological) (16) Diarrhoea (11) Abnormal ultrasound finding (7) Decreased haematocrit (7) Other (39) Digestive (21) Neurologic (17) Effectiveness (6)
Showing up to 50 matching reports.

USA-USFDACVM-2026-US-014485

Received 2026-03-25 · MSK · MSK

Non-serious
Species
Dog
Breed
Retriever - Labrador
Size / weight
25-49 lb (22.044 Kilogram)
Age
4-7 years (6.75 Year)
Sex
Female Neutered
Region
USA
Reactions
Not himself/herselfAnorexiaLethargy (see also Central nervous system depression in Neurological)Anaemia NOSThrombocytopeniaVomitingDecreased haematocritUncomfortable
Body systems
OtherDigestiveNeurologic
Outcomes
Recovered/Normal

USA-USFDACVM-2026-US-014449

Received 2026-03-25 · MSK · MSK

Serious
Species
Dog
Breed
Schnauzer - Miniature
Size / weight
10-24 lb (10.16 Kilogram)
Age
4-7 years (5 Year)
Sex
Male Neutered
Region
USA
Reactions
LamenessWobblinessLethargy (see also Central nervous system depression in Neurological)Unable to walkWeaknessFeverImmune-mediated polyarthritisGastritisAbdominal cavity disorder NOSAbnormal ultrasound findingHyperproteinaemiaLymphopeniaEosinopeniaMedication error NOS
Body systems
OtherNeurologic
Outcomes
Ongoing

USA-USFDACVM-2026-US-013917

Received 2026-03-25 · MSK · MSK

Serious
Species
Dog
Size / weight
10-24 lb (4.536 Kilogram)
Age
8+ years (12 Year)
Sex
Male Neutered
Region
USA
Reactions
Lateral recumbencyAgonal breathingDeath
Body systems
Other
Outcomes
Died

USA-USFDACVM-2026-US-014118

Received 2026-03-24 · MSK · MSK

Non-serious
Species
Dog
Breed
Retriever - Labrador
Size / weight
50-99 lb (33.11 Kilogram)
Age
8+ years (12 Year)
Sex
Female Neutered
Region
USA
Reactions
ThrombocytopeniaLethargy (see also Central nervous system depression in Neurological)
Body systems
OtherNeurologic
Outcomes
Outcome Unknown

USA-USFDACVM-2026-US-012782

Received 2026-03-17 · MSK · MSK

Serious
Species
Dog
Breed
Setter - English
Size / weight
25-49 lb (21.772 Kilogram)
Age
8+ years (9 Year)
Sex
Male Neutered
Region
USA
Reactions
Dilated renal pelvisIntestinal thickeningAbnormal ultrasound findingBradycardiaPale mucous membraneDiarrhoeaWeight lossLethargy (see also Central nervous system depression in Neurological)LymphomaMedication error NOS
Body systems
OtherDigestiveNeurologic
Outcomes
Ongoing

USA-USFDACVM-2026-US-013316

Received 2026-03-16 · MSK · MSK

Serious
Species
Dog
Breed
['Shepherd Dog - German', 'Dog (unknown)']
Size / weight
50-99 lb (31.842 Kilogram)
Age
8+ years (13 Year)
Sex
Male Neutered
Region
USA
Reactions
Emesis (multiple)Reluctant to moveUnable to riseDifficulty to riseWeaknessNot eatingNot drinkingHeavy breathingPantingLethargy (see also Central nervous system depression in Neurological)Increased heart rateIncreased respiratory rateAbdominal discomfortDehydrationLeukocytosis NOSMonocytosisAbnormal ultrasound finding
Body systems
DigestiveOtherNeurologic
Outcomes
Ongoing

USA-USFDACVM-2026-US-012837

Received 2026-03-16 · MSK · MSK

Serious
Species
Dog
Breed
['Retriever - Golden', 'Poodle (unspecified)']
Size / weight
25-49 lb (16.783 Kilogram)
Age
1-3 years (3 Year)
Sex
Male Neutered
Region
USA
Reactions
VomitingSwelling around eye (see also Immune system disorders)WhiningUncomfortableFeverInjected scleraPinnal erythemaHypersensitivity reaction
Body systems
DigestiveSkin & allergyOther
Outcomes
Ongoing

USA-USFDACVM-2026-US-011901

Received 2026-03-11 · MSK · MSK

Non-serious
Species
Cat
Breed
Domestic Shorthair
Size / weight
10-24 lb (9.253 Kilogram)
Age
8+ years (12 Year)
Sex
Male Neutered
Region
USA
Reactions
Peripheral neuropathyPlantigrade posture
Body systems
Other
Outcomes
Ongoing

USA-USFDACVM-2026-US-011010

Received 2026-03-02 · MSK · MSK

Non-serious
Species
Cat
Breed
Domestic Shorthair
Size / weight
10-24 lb (4.71 Kilogram)
Age
8+ years (9 Year)
Sex
Male Neutered
Region
USA
Reactions
Lethargy (see also Central nervous system depression in Neurological)DiarrhoeaAnisocoriaHypoglycaemia
Body systems
NeurologicDigestiveOther
Outcomes
Ongoing

USA-USFDACVM-2026-US-008594

Received 2026-02-25 · MSK · MSK

Non-serious
Species
Cat
Breed
Cat (unknown)
Age
8+ years (12.66 Year)
Sex
Male Neutered
Region
USA
Reactions
DiarrhoeaWeight lossElevated creatinineElevated symmetrical dimethylarginine (SDMA)Other abnormal test result NOSElevated pancreatic enzymesHypoglycaemiaGlucosuria
Body systems
DigestiveOther
Outcomes
Ongoing

USA-USFDACVM-2026-US-008762

Received 2026-02-19 · MSK · MSK

Serious
Species
Dog
Breed
['Retriever - Labrador', 'Crossbred Canine/dog']
Age
1-3 years (2.25 Year)
Sex
Male Neutered
Region
USA
Reactions
DiarrhoeaLack of efficacy (endoparasite) - heartwormOtitis NOSCystitisCrustPruritus
Body systems
DigestiveEffectivenessOtherSkin & allergy
Outcomes
Outcome Unknown

USA-USFDACVM-2026-US-011611

Received 2026-02-14 · MSK · MSK

Serious
Species
Cat
Breed
Domestic Shorthair
Size / weight
10-24 lb (6.3 Kilogram)
Age
4-7 years (6 Year)
Sex
Male Neutered
Region
USA
Reactions
DeathDullNot himself/herselfHead pressingHypotensionUnresponsive to stimuli
Body systems
Other
Outcomes
Died

USA-USFDACVM-2026-US-007141

Received 2026-02-09 · MSK · MSK

Non-serious
Species
Cat
Breed
Domestic Longhair
Size / weight
Under 10 lb (3.447 Kilogram)
Age
8+ years (15 Year)
Sex
Male Neutered
Region
USA
Reactions
Laboured breathing
Body systems
Other
Outcomes
Recovered/Normal

USA-USFDACVM-2026-US-004873

Received 2026-02-03 · MSK · MSK

Serious
Species
Dog
Breed
['Spaniel - King Charles Cavalier', 'Poodle (unspecified)']
Size / weight
10-24 lb (5.4 Kilogram)
Age
4-7 years (4 Year)
Sex
Female Unknown
Region
USA
Reactions
Emesis (multiple)Not eatingDehydrationQuietLeukocytosis NOSNeutrophiliaHyponatremiaHypokalaemiaHypochloraemiaMelaenaGastric dilationIleusGastric ulcerAbnormal ultrasound findingLack of efficacy - NOSBloody diarrhoea
Body systems
DigestiveOtherEffectiveness
Outcomes
Ongoing

USA-USFDACVM-2026-US-005800

Received 2026-02-02 · MSK · MSK

Serious
Species
Cat
Breed
Domestic Shorthair
Size / weight
10-24 lb (6.3 Kilogram)
Age
4-7 years (6 Year)
Sex
Male Neutered
Region
USA
Reactions
DeathDullNot himself/herselfHead pressingHypotensionUnresponsive to stimuli
Body systems
Other
Outcomes
Died

USA-USFDACVM-2026-US-003352

Received 2026-01-27 · MSK · MSK

Serious
Species
Cat
Breed
Domestic Shorthair
Size / weight
Under 10 lb (3.992 Kilogram)
Age
8+ years (13 Year)
Sex
Female Neutered
Region
USA
Reactions
DiarrhoeaDecreased appetiteLethargy (see also Central nervous system depression in Neurological)Bloody diarrhoeaDry mucous membraneOpen mouth breathingUnresponsive to stimuliDecreased haematocritIncreased percentage reticulocytesRegenerative anaemiaIntentional misuseThrombocytopeniaHypersalivationHeart murmur
Body systems
DigestiveNeurologicOther
Outcomes
Ongoing

USA-USFDACVM-2026-US-003528

Received 2026-01-19 · MSK · MSK

Serious
Species
Cat
Breed
Domestic Shorthair
Size / weight
Under 10 lb (4 Kilogram)
Age
8+ years (13 Year)
Sex
Female Neutered
Region
USA
Reactions
Unresponsive to stimuliOpen mouth breathingAnorexiaLethargy (see also Central nervous system depression in Neurological)DiarrhoeaDry mucous membraneBloody diarrhoeaIncreased percentage reticulocytesDecreased haematocritRegenerative anaemiaThrombocytopeniaHypersalivationMurmur
Body systems
OtherDigestiveNeurologic
Outcomes
Ongoing

USA-USFDACVM-2026-US-003268

Received 2026-01-14 · MSK · MSK

Serious
Species
Dog
Breed
Dachshund (unspecified)
Size / weight
10-24 lb (5.8 Kilogram)
Age
8+ years (15 Year)
Sex
Male Neutered
Region
USA
Reactions
VomitingLethargy (see also Central nervous system depression in Neurological)RetchingDental diseaseDry mucous membraneDehydrationAnorexiaBloody diarrhoeaIncreased heart rateIncreased respiratory ratePale mucous membraneJaundiceHeart murmurTense abdomenLeukocytosis NOSNeutrophiliaLymphocytosisMonocytosisLow platelet countAzotaemiaElevated blood urea nitrogen (BUN)HyperphosphataemiaElevated alanine aminotransferase (ALT)Elevated serum alkaline phosphatase (ALP)Elevated total bilirubinElevated cholesterol (total)Blood in urineProteinuriaLiver disorder NOSPancreas disorderIntestinal thickeningUrinary tract disorder NOSNon-regenerative anaemiaHypokalaemiaNot eatingDecreased red blood cell countDecreased haematocritPolyuriaPolydipsiaAbdominal discomfortIncreased percentage reticulocytesPlatelet disorder NOSLack of efficacy - NOSGut sounds decreasedOther blood disorder NOSBilirubinuriaAbnormal ultrasound findingElevated gamma-glutamyl transferase (GGT)ThrombocytosisIleus
Body systems
DigestiveNeurologicOtherEffectiveness
Outcomes
Ongoing

USA-USFDACVM-2025-US-075004

Received 2025-12-23 · MSK · MSK

Non-serious
Species
Cat
Breed
Domestic Shorthair
Size / weight
10-24 lb (5.09 Kilogram)
Age
8+ years (9.5 Year)
Sex
Male Neutered
Region
USA
Reactions
Application site hair lossApplication site bleedingApplication site reddening
Body systems
Skin & allergyOther
Outcomes
Outcome Unknown

USA-USFDACVM-2025-US-073901

Received 2025-12-19 · MSK · MSK

Serious
Species
Dog
Breed
Terrier - Bull - American Pit
Size / weight
50-99 lb (37 Kilogram)
Age
4-7 years (7 Year)
Sex
Male Neutered
Region
USA
Reactions
Loose stoolEmesis (multiple)Decreased appetiteDecreased drinkingMedication error NOSLack of efficacy - NOS
Body systems
OtherDigestiveEffectiveness
Outcomes
Ongoing

USA-USFDACVM-2025-US-073737

Received 2025-12-16 · MSK · MSK

Non-serious
Species
Dog
Breed
Cattle Dog - Australian (blue heeler, red heeler, Queensland cattledog)
Size / weight
25-49 lb (14.061 Kilogram)
Age
8+ years (8 Year)
Sex
Male Neutered
Region
USA
Reactions
HaematuriaStranguriaPollakiuriaUrine abnormalities NOSBilirubinuriaHypophosphataemiaHypochloraemia
Body systems
Other
Outcomes
Recovered/Normal

USA-USFDACVM-2025-US-073969

Received 2025-12-11 · MSK · MSK

Serious
Species
Dog
Breed
['Chihuahua', 'Mixed (Dog)']
Size / weight
Under 10 lb (2.268 Kilogram)
Age
4-7 years (7 Year)
Sex
Male Neutered
Region
USA
Reactions
ObtundedHypothermiaHypotensionHypoglycaemiaCardiorespiratory arrestProlonged one stage prothrombin time (OSPT)HyperphosphataemiaHypercalcaemiaElevated alanine aminotransferase (ALT)Elevated aspartate aminotransferase (AST)HypoproteinaemiaHypoalbuminaemiaReduced globulinsDecreased cholesterol (total)ThrombocytopeniaHaematocheziaRegurgitationDeath by euthanasiaLateral recumbencyDehydration
Body systems
Other
Outcomes
Euthanized

USA-USFDACVM-2025-US-072879

Received 2025-12-10 · MSK · MSK

Serious
Species
Dog
Breed
Retriever - Labrador
Size / weight
50-99 lb (34.292 Kilogram)
Age
8+ years (11 Year)
Sex
Female Neutered
Region
USA
Reactions
Lethargy (see also Central nervous system depression in Neurological)Medication error NOSAtaxiaHyperactivityTremor
Body systems
NeurologicOther
Outcomes
Recovered/Normal

USA-USFDACVM-2025-US-072729

Received 2025-12-05 · MSK · MSK

Non-serious
Species
Dog
Breed
Terrier - Bull
Size / weight
25-49 lb (17.6 Kilogram)
Age
4-7 years (7 Year)
Sex
Female Neutered
Region
USA
Reactions
Leucopenia NOSAnaemia NOSHypoalbuminaemiaNeutropeniaPyodermaReduced globulinsHypophosphataemiaNon-regenerative anaemiaLow serum alkaline phosphatase (ALP)Pale mucous membraneElevated alanine aminotransferase (ALT)Decreased packed cell volume (PCV)Lethargy (see also Central nervous system depression in Neurological)HypocalcaemiaElevated aspartate aminotransferase (AST)HypoproteinaemiaProteinuriaElectrolyte disorderDisorder of red blood cell NOSElevated creatine-kinase (CK)Other coagulation investigation abnormalityIncreased band neutrophiliaElevated mean corpuscular volume (MCV)LymphopeniaOther abnormal test result NOSDiarrhoeaPanleucopeniaEosinopeniaDecreased haematocritIncreased percentage reticulocytes
Body systems
OtherNeurologicDigestive
Outcomes
Ongoing

USA-USFDACVM-2025-US-072061

Received 2025-12-05 · MSK · MSK

Non-serious
Species
Dog
Breed
Corso Dog
Size / weight
100+ lb (63.5 Kilogram)
Age
4-7 years (5 Year)
Sex
Male Intact
Region
USA
Reactions
UrinationExcessive thirstInappropriate urination
Body systems
Other
Outcomes
Outcome Unknown

USA-USFDACVM-2025-US-072504

Received 2025-12-04 · MSK · MSK

Serious
Species
Dog
Breed
Terrier - Bull - American Pit
Size / weight
50-99 lb (29.03 Kilogram)
Age
1-3 years (2 Year)
Sex
Male Neutered
Region
USA
Reactions
Otitis externaTrigeminus paralysisVomitingCoughMuscle atrophy (see also Muscle wasting)Elevated serum alkaline phosphatase (ALP)Elevated alanine aminotransferase (ALT)HypersalivationUnusual stool colourErythema (for urticaria see Immune SOC)Elevated gamma-glutamyl transferase (GGT)Elevated total bilirubinAbnormal ultrasound findingHepatic fibrosisHepatitisLethargy (see also Central nervous system depression in Neurological)AngioedemaGeneralised rashDyspnoeaIncreased lung soundsLeucocytosis NOSIcterusAbnormal radiograph findingJaw disorder
Body systems
OtherDigestiveSkin & allergyNeurologic
Outcomes
Ongoing

USA-USFDACVM-2025-US-072442

Received 2025-12-02 · MSK · MSK

Non-serious
Species
Cat
Breed
Siamese
Size / weight
10-24 lb (5.98 Kilogram)
Age
4-7 years (7 Year)
Sex
Male Neutered
Region
USA
Reactions
Weight lossDiarrhoeaDecreased appetiteElevated gamma-glutamyl transferase (GGT)Unclassifiable adverse eventHyperglycaemia
Body systems
OtherDigestive
Outcomes
Recovered/Normal

USA-USFDACVM-2025-US-071394

Received 2025-12-02 · MSK · MSK

Serious
Species
Dog
Breed
Terrier (unspecified)
Size / weight
Under 10 lb (2.49 Kilogram)
Age
8+ years (12.75 Year)
Sex
Female Unknown
Region
USA
Reactions
Decreased appetiteHypoalbuminaemiaDecreased cholesterol (total)
Body systems
DigestiveOther
Outcomes
Ongoing

USA-USFDACVM-2025-US-071202

Received 2025-12-02 · MSK · MSK

Non-serious
Species
Dog
Breed
Catahoula Leopard Dog
Size / weight
50-99 lb (28.803 Kilogram)
Age
4-7 years (6 Year)
Sex
Female Neutered
Region
USA
Reactions
Pica NOSDiarrhoeaBloody stoolWeight loss
Body systems
OtherDigestive
Outcomes
Ongoing

USA-USFDACVM-2025-US-073471

Received 2025-12-01 · MSK · MSK

Serious
Species
Dog
Breed
Sheepdog (unspecified)
Size / weight
100+ lb (51.71 Kilogram)
Age
8+ years (1 Year)
Sex
Male Intact
Region
USA
Reactions
WobblinessUnable to walkSpinal pain NOSHemiparesis (weakness L or R side)Impaired proprioceptionDeath by euthanasiaUrinary incontinence
Body systems
Other
Outcomes
Euthanized

USA-USFDACVM-2025-US-071623

Received 2025-12-01 · MSK · MSK

Serious
Species
Dog
Breed
['Retriever - Labrador', 'Dog (unknown)']
Size / weight
25-49 lb (17.69 Kilogram)
Age
8+ years (12 Year)
Sex
Male Neutered
Region
USA
Reactions
VomitingNot eatingWeight lossIcterusLeucopenia NOSDecreased red blood cell countThrombocytopeniaElevated alanine aminotransferase (ALT)Elevated serum alkaline phosphatase (ALP)Elevated total bilirubinHigh pancreatic-specific lipaseUrinary incontinenceInfectious disease NOSOverdoseGall bladder & bile duct disorder NOSLymphopeniaNeutropeniaSplenomegalyLoose stoolPancreas disorderHepatomegalyDeath by euthanasiaHypoalbuminaemiaHypoproteinaemiaFluid in abdomen NOSElevated blood urea nitrogen (BUN)Elevated bile acidsAbnormal ultrasound findingElevated cholesterol (total)Enlarged lymph node (localised)Reduced globulinsMonocytopeniaEosinopeniaLiver nodules
Body systems
DigestiveOther
Outcomes
Euthanized

USA-USFDACVM-2025-US-071839

Received 2025-11-28 · MSK · MSK

Serious
Species
Cat
Breed
Domestic Shorthair
Size / weight
10-24 lb (7.257 Kilogram)
Age
1-3 years (2 Year)
Sex
Male Neutered
Region
USA
Reactions
Lethargy (see also Central nervous system depression in Neurological)Stumbling gaitNot eatingNot drinkingCold feeling to the touchWobblinessNot urinatingUncomfortableFeverWeak pulseStiffness limbDecreased haematocritDecreased haemoglobinDecreased mean corpuscular volume (MCV)Decreased mean corpuscular haemoglobin concentration (MCHC)Red blood cell disorderHyperglycaemiaLow blood urea nitrogen (BUN)Low pancreatic enzymesUnable to walkEosinopenia
Body systems
NeurologicOther
Outcomes
Ongoing

USA-USFDACVM-2025-US-073558

Received 2025-11-27 · MSK · MSK

Non-serious
Species
Dog
Breed
Chihuahua
Size / weight
10-24 lb (4.99 Kilogram)
Age
1-3 years (1 Year)
Sex
Female Neutered
Region
USA
Reactions
Limb weaknessProprioception abnormality
Body systems
Other
Outcomes
Ongoing

USA-USFDACVM-2025-US-071910

Received 2025-11-27 · MSK · MSK

Serious
Species
Dog
Breed
Pointer (unspecified)
Size / weight
25-49 lb (18.234 Kilogram)
Age
8+ years (9.5 Year)
Sex
Male Neutered
Region
USA
Reactions
Lethargy (see also Central nervous system depression in Neurological)DiarrhoeaBloody diarrhoeaEmesisIntestinal stasisDecreased bowel movementsMucous stoolAbnormal stool colouration
Body systems
NeurologicDigestiveOther
Outcomes
Ongoing

USA-USFDACVM-2025-US-067364

Received 2025-11-14 · MSK · MSK

Serious
Species
Cat
Breed
Domestic Shorthair
Size / weight
10-24 lb (6.804 Kilogram)
Age
8+ years (14 Year)
Sex
Female Unknown
Region
USA
Reactions
DehydrationEmesis (multiple)Elevated cholesterol (total)Abnormal radiograph findingLack of efficacy - NOSWeaknessUrinary incontinenceAtaxiaDullRecumbencyIncreased coagulation timeElevated aspartate aminotransferase (AST)Elevated creatinineHypokalaemiaElevated gamma-glutamyl transferase (GGT)Elevated triglycerideBlood in urineHypothermiaDisseminated intravascular coagulationCardiorespiratory arrestDeathIntentional misuseShockDistension of abdomen
Body systems
OtherDigestiveEffectivenessNeurologic
Outcomes
Died

USA-USFDACVM-2025-US-067000

Received 2025-11-14 · MSK · MSK

Serious
Species
Cat
Breed
Domestic Shorthair
Size / weight
Under 10 lb (3.992 Kilogram)
Age
8+ years (13 Year)
Sex
Female Unknown
Region
USA
Reactions
DiarrhoeaDecreased appetiteLethargy (see also Central nervous system depression in Neurological)Bloody diarrhoeaDry mucous membraneOpen mouth breathingUnresponsive to stimuliDecreased haematocritIncreased percentage reticulocytesRegenerative anaemiaIntentional misuseUnderdoseThrombocytopeniaHeart murmurHypersalivation
Body systems
DigestiveNeurologicOther
Outcomes
Ongoing

USA-USFDACVM-2025-US-072109

Received 2025-11-11 · MSK · MSK

Non-serious
Species
Cat
Breed
Domestic Longhair
Size / weight
10-24 lb (4.98 Kilogram)
Age
4-7 years (4 Year)
Sex
Female Neutered
Region
USA
Reactions
Behavioural disorder NOSUNPALATABLE
Body systems
BehaviorOther
Outcomes
Ongoing

USA-USFDACVM-2025-US-067345

Received 2025-11-09 · MSK · MSK

Non-serious
Species
Dog
Breed
Spaniel (unspecified)
Size / weight
25-49 lb (15.33 Kilogram)
Age
8+ years (16.17 Year)
Sex
Male Neutered
Region
USA
Reactions
Lack of efficacy - NOSMedication error NOSElevated serum alkaline phosphatase (ALP)Elevated amylaseElevated blood urea nitrogen (BUN)Elevated symmetrical dimethylarginine (SDMA)Thrombocytosis
Body systems
EffectivenessOther
Outcomes
Ongoing

USA-USFDACVM-2025-US-062675

Received 2025-10-21 · MSK · MSK

Serious
Species
Dog
Breed
Dachshund - Standard Long-haired
Size / weight
10-24 lb (5.996 Kilogram)
Age
8+ years (15 Year)
Sex
Female Unknown
Region
USA
Reactions
Lethargy (see also Central nervous system depression in Neurological)SedationLying downElevated temperatureTachycardiaDeathUnresponsive to stimuli
Body systems
NeurologicOther
Outcomes
Died

Tap or hover a reaction to see what it means in plain language.

Tracked signals
32
Reported cases
32
Serious reports
22
Species represented
2
Grouped by Body System
Digestive (2) · Loss of appetite, Bloody diarrhoea Skin & allergy (1) · Application site hair loss Neurologic (1) · Unsteady walking (ataxia) Behavior (2) · Circling - behavioural disorder, Behavioral disorder (unspecified) Other (26) · Death by euthanasia, Death, Cystitis
Most Reported Reactions
Reaction Body system Cases Species Serious cases
Neurologic 1 Dog 1
Digestive 1 Cat 1
Other 1 Dog 1
Other 1 Cat 1
Other 1 Dog 1
Other 1 Dog 1
Other 1 Dog 1
Other 1 Cat 1

Species coverage: Dog (24) Cat (8)

View detailed reaction table
Reaction Body system Species Seriousness Frequency Reports
Neurologic Dog Serious - 1
Digestive Cat Serious - 1
Other Dog Serious - 1
Other Cat Serious - 1
Other Dog Serious - 1
Other Dog Serious - 1
Other Dog Serious - 1
Other Cat Serious - 1
Other Dog Serious - 1
Behavior Dog Non-serious - 1
Other Dog Serious - 1
Other Dog Serious - 1
Other Dog Non-serious - 1
Digestive Dog Serious - 1
Other Cat Serious - 1
Other Dog Non-serious - 1
Behavior Dog Serious - 1
Other Dog Non-serious - 1
Other Dog Serious - 1
Other Cat Non-serious - 1
Skin & allergy Cat Non-serious - 1
Other Cat Non-serious - 1
Other Cat Non-serious - 1
Other Dog Serious - 1
Other Dog Non-serious - 1
Other Dog Serious - 1
Other Dog Non-serious - 1
Other Dog Serious - 1
Other Dog Serious - 1
Other Dog Serious - 1
Other Dog Serious - 1
Other Dog Serious - 1
Source metadata:

Storage & Handling

Store at room temperature.

Source Documents

The most useful source links appear first; full previews and metadata stay in the veterinary/professional layer.

Use original documents to confirm product-specific warnings, ingredients, and handling details with your veterinarian.

AYRADIA™ SPL · SPL METRONIDAZOLE SPL SPL · Structured Product Label Metronidazole SPL SPL · Structured Product Label

Full source previews and metadata remain in the veterinary/professional layer.

Owner handouts

0
No owner handouts linked yet.

Official label / PI

0
No official label or package insert links yet.

SPL

6

FOI

1

AYRADIA™

SPL · SPL

Open original
FDA Structured Product Label

AYRADIA™

Rendered from Roxee's cached FDA SPL package contents for on-page reading. Use Open original for the raw FDA ZIP/XML source.

Sponsor
Virbac AH, Inc.
NADA
141-572
Status
RX
Form
Suspension
Route
Oral
Species
Dog
Composition / specifications
125 mg/mL

Dogs

Indication

For the treatment of Giardia duodenalis infection in dogs.

Dosage

25 mg/kg (11.3 mg/lb) of body weight, using the supplied syringe, twice daily for five consecutive days

METRONIDAZOLE SPL

SPL · Structured Product Label

Open original
FDA Structured Product Label XML for METRONIDAZOLE. Use the source link for the full official labeling record.

Metronidazole SPL

SPL · Structured Product Label

Open original
FDA Structured Product Label XML for Metronidazole. Use the source link for the full official labeling record.

AYRADIA SPL

SPL · Structured Product Label

Open original
FDA Structured Product Label XML for AYRADIA. Use the source link for the full official labeling record.

Metroplex SPL

SPL · Structured Product Label

Open original
FDA Structured Product Label XML for Metroplex. Use the source link for the full official labeling record.

MetroCleanse SPL

SPL · Structured Product Label

Open original
FDA Structured Product Label XML for MetroCleanse. Use the source link for the full official labeling record.

N-141572-G-0006-OT-AA_foi.pdf

FOI · FOI

Open original
Source metadata:
Veterinary reference (advanced)

Canonical medication sections are above. This legacy block remains available for deeper cross-reference without cluttering the primary workflow.

At a Glance

Quick facts and links to official labeling and safety signals.

Data freshness
  • Reference facts: Source Roxee | Refreshed Aug 6, 2026, 7:47 PM UTC
    The reference fact projection used for browse cards and quick facts.
  • Animal Drugs @ FDA: Source FDA | Refreshed Aug 6, 2026, 7:46 PM UTC
    Applications/products are imported from FDA export data.
  • Animal Drugs @ FDA previews: Source FDA | Refreshed Feb 9, 2026, 3:05 AM UTC
    Label highlights/doc links are fetched from FDA preview endpoints.
  • Animal Drug Product Listing Directory (NDC): Source FDA | Refreshed Aug 6, 2026, 7:47 PM UTC
    Package/product NDCs from FDA’s electronic listing directory (XLS).
  • openFDA reaction terms: Source FDA openFDA | Refreshed Aug 6, 2026, 7:52 PM UTC
  • openFDA case summaries: Source FDA openFDA | Refreshed Aug 6, 2026, 7:52 PM UTC
Official (FDA)
Identity: Generic ingredient • FDA branded products available
Official FDA brands: AYRADIA METRONIDAZOLE MetroCleanse Metronidazole Metroplex
Manufacturer mapping: Multiple FDA labelers
Case-reported brands (openFDA): MSK
Catalog species: Both • FDA-labeled species: Dog
Rx/OTC: RX
Form/route: Suspension • Oral
Applications: NADA 141-572
NDC: Packages 43457-537-25 51311-034-10 51311-034-30 53745-016-01 53745-016-02 55999-081-12 • Products 43457 51311 53745 55999 86184
Documents: 1 (FOI: 1) • SPL: 1 • Label highlights • Official documents
Safety (openFDA)
Top reactions: Dog 187 • Cat 78 • View
Case summaries: 39 (showing 8) • View
openFDA reports are unverified and do not prove causation.
Diagnosis Codes

Diagnosis-code mappings are not available for this medication yet.

Counseling and Monitoring Highlights

Global Pet owner/Vet mode is controlled in the header. This section avoids duplicate in-page persona tabs.

Owner-facing counseling points
  • Use caution with liver disease. Avoid overdosing. (Contraindication, High)
Top reaction signals
Unsteady walking (ataxia) (1) Loss of appetite (1) Death by euthanasia (1) Death (1) Cystitis (1) Crust (1) Cough (1) Cold feeling to the touch (1)

Identifiers & Packages

Normalized identifiers (NDC/NADA/ANADA) and package metadata from regulator listings.

Identifiers
NADA: 141572 NDC Package: 17163-015-16 NDC Package: 17163-016-17 NDC Package: 43457-537-25 NDC Package: 46144-602-01 NDC Package: 51311-034-10 NDC Package: 51311-034-30 NDC Package: 53745-016-01 NDC Package: 53745-016-02 NDC Package: 55999-081-12 NDC Package: 55999-081-15 NDC Package: 55999-081-18 NDC Package: 55999-081-56 NDC Package: 55999-081-57 NDC Package: 62157-529-01 NDC Package: 63732-2047-9 NDC Package: 73309-199-01 NDC Package: 86184-255-01 NDC Product: 17163 NDC Product: 43457 NDC Product: 46144 NDC Product: 51311 NDC Product: 53745 NDC Product: 55999
Package NDC Product NDC Form / Route Status
17163-015-16 17163 -
17163-016-17 17163 -
43457-537-25 43457 -
46144-602-01 46144 -
51311-034-10 51311 -
51311-034-30 51311 -
53745-016-01 53745 -
53745-016-02 53745 -
55999-081-12 55999 -
55999-081-15 55999 -
55999-081-18 55999 -
55999-081-56 55999 -
55999-081-57 55999 -
62157-529-01 62157 -
63732-2047-9 63732 -
73309-199-01 73309 -
86184-255-01 86184 -

Enriched Documents

Documents are tiered by source trust: Official, Clinical, Manufacturer, Marketing.

  • METRONIDAZOLE SPL • Structured Product Label • Official
    FDA Structured Product Label from the electronic animal drug product listing directory.
  • Metronidazole SPL • Structured Product Label • Official
    FDA Structured Product Label from the electronic animal drug product listing directory.
  • AYRADIA SPL • Structured Product Label • Official
    FDA Structured Product Label from the electronic animal drug product listing directory.
  • Metroplex SPL • Structured Product Label • Official
    FDA Structured Product Label from the electronic animal drug product listing directory.
  • MetroCleanse SPL • Structured Product Label • Official
    FDA Structured Product Label from the electronic animal drug product listing directory.
  • N-141572-G-0006-OT-AA_foi.pdf • FOI summary • Official • March 26, 2024
    FDA FOI summary for application 141572

Data Sources & Change Log

Every non-trivial field is expected to include provenance and update timestamps.

Official 122 Clinical 4 Manufacturer 0 Marketing 0
Current Field Facts
  • side_effects: GI upset. High doses can cause neurologic signs (ataxia, tremors). (Clinical, 2026-04-11)
  • storage_handling: Store at room temperature. (Clinical, 2026-04-12)
  • storage_handling: Store at room temperature. (Clinical, 2026-04-11)
  • storage_handling: Store at room temperature. (Clinical, 2026-02-12)
  • contraindications: Use caution with liver disease. Avoid overdosing. (Official, 2026-04-12)
  • contraindications: Use caution with liver disease. Avoid overdosing. (Official, 2026-04-11)
  • contraindications: Use caution with liver disease. Avoid overdosing. (Official, 2026-02-12)
  • indications: For the treatment of Giardia duodenalis infection in dogs. (Official, 2026-08-06)
  • indications: For the treatment of Giardia duodenalis infection in dogs. (Official, 2026-08-05)
  • indications: For the treatment of Giardia duodenalis infection in dogs. (Official, 2026-08-04)
  • indications: For the treatment of Giardia duodenalis infection in dogs. (Official, 2026-08-03)
  • indications: For the treatment of Giardia duodenalis infection in dogs. (Official, 2026-08-02)
  • indications: For the treatment of Giardia duodenalis infection in dogs. (Official, 2026-08-01)
  • indications: For the treatment of Giardia duodenalis infection in dogs. (Official, 2026-07-31)
  • indications: For the treatment of Giardia duodenalis infection in dogs. (Official, 2026-07-30)
  • indications: For the treatment of Giardia duodenalis infection in dogs. (Official, 2026-07-29)
  • indications: For the treatment of Giardia duodenalis infection in dogs. (Official, 2026-07-28)
  • indications: For the treatment of Giardia duodenalis infection in dogs. (Official, 2026-07-27)
  • indications: For the treatment of Giardia duodenalis infection in dogs. (Official, 2026-07-26)
  • indications: For the treatment of Giardia duodenalis infection in dogs. (Official, 2026-07-25)
Recent Revisions
  • side_effects updated 2026-04-12 10:05 by etl_backfill • Backfilled from existing medication fields
  • contraindications updated 2026-04-12 10:05 by etl_backfill • Backfilled from existing medication fields
  • usage updated 2026-04-12 10:05 by etl_backfill • Backfilled from existing medication fields
  • side_effects updated 2026-04-11 10:05 by etl_backfill • Backfilled from existing medication fields
  • contraindications updated 2026-04-11 10:05 by etl_backfill • Backfilled from existing medication fields
  • usage updated 2026-04-11 10:05 by etl_backfill • Backfilled from existing medication fields
  • side_effects updated 2026-02-12 19:40 by etl_backfill • Backfilled from existing medication fields
  • contraindications updated 2026-02-12 19:40 by etl_backfill • Backfilled from existing medication fields
  • usage updated 2026-02-12 19:40 by etl_backfill • Backfilled from existing medication fields

FDA Products & Applications (Animal Drugs @ FDA)

Official sponsor/proprietary-name/application-status records linked by active ingredient.

Product Sponsor Application Status Published
AYRADIA™
RX
Metronidazole
Suspension • Oral
Label highlights
Official documents
Virbac AH, Inc. NADA 141-572 Approved Mar 26, 2024

Data source: FDA Animal Drugs @ FDA (public search export).

What It's For (FDA Label Highlights)

Extracted from FDA Animal Drugs @ FDA product labeling. Always confirm details with your veterinarian.

Species: Dog
Composition / specifications
125 mg/mL
Dogs
Indication

For the treatment of Giardia duodenalis infection in dogs.

Dosage

25 mg/kg (11.3 mg/lb) of body weight, using the supplied syringe, twice daily for five consecutive days

Limitations

FDA page: Open in Animal Drugs @ FDA

Usage

Antibiotic/antiprotozoal used for certain GI infections and inflammation.

Source: FDA Animal Drugs @ FDA • Reference

Contraindications

Use caution with liver disease. Avoid overdosing.

Side Effects

GI upset. High doses can cause neurologic signs (ataxia, tremors).

Source: FDA openFDA • Reference

Top Reported Reactions (openFDA)

De-duplicated reaction terms grouped by body system from FDA openFDA reports (not verified; does not prove causation).

Digestive
Loss of appetite (1) • Cat Bloody diarrhoea (1) • Dog

Showing top 5 for Digestive.

Skin & allergy
Application site hair loss (1) • Cat

Showing top 5 for Skin & allergy.

Neurologic
Unsteady walking (1) • Dog

Showing top 5 for Neurologic.

Behavior
Circling - behavioural disorder (1) • Dog Behavioral disorder (1) • Dog

Showing top 5 for Behavior.

Other
Death by euthanasia (1) • Dog Death (1) • Cat Cystitis (1) • Dog Crust (1) • Dog Cough (1) • Dog
Show more (21)
Cold feeling to the touch (1) • Cat Cognitive disorder NOS (1) • Dog Cardiorespiratory arrest (1) • Dog Bradycardia (1) • Dog Bloody stool (1) • Dog Blood in urine (1) • Cat Bilirubinuria (1) • Dog Barking (1) • Dog Azotaemia (1) • Dog Application site reddening (1) • Cat Application site bleeding (1) • Cat Anisocoria (1) • Cat Angioedema (1) • Dog Anaemia NOS (1) • Dog Agonal breathing (1) • Dog Agitation (1) • Dog Abnormal ultrasound finding (1) • Dog Abnormal stool colouration (1) • Dog Abnormal radiograph finding (1) • Dog Abdominal discomfort (1) • Dog Abdominal cavity disorder NOS (1) • Dog

Showing top 5 for Other.

Data source: FDA openFDA Animal & Veterinary adverse event reports.

Adverse Event Case Summaries (openFDA)

These are individual FDA adverse event reports. They are unverified and do not prove the medication caused the reaction.

Dog, Retriever - Labrador, Female, 6.75 year, 22.044 kilogram • Drug: MSK, Unknown • Reactions: Not himself/herself, Loss of appetite, Tiredness (lethargy), Anaemia NOS, Thrombocytopenia… • Outcome: Recovered/Normal

  • Report ID: USA-USFDACVM-2026-US-014485
  • Serious AE: No
  • Treated For AE: Yes
  • Sex: Female
  • Age: 6.75 Year
  • Weight: 22.044 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Unknown
Reactions Reported:
Not himself/herself Loss of appetite Tiredness (lethargy) Anaemia NOS Thrombocytopenia Vomiting Decreased haematocrit Uncomfortable
Outcomes: Recovered/Normal

Dog, Schnauzer - Miniature, Male, 5 year, 10.16 kilogram • Drug: MSK, Unassigned, Oral • Reactions: Lameness, Wobbliness, Tiredness (lethargy), Unable to walk, Weakness… • Outcome: Ongoing

  • Report ID: USA-USFDACVM-2026-US-014449
  • Serious AE: Yes
  • Treated For AE: Yes
  • Sex: Male
  • Age: 5.00 Year
  • Weight: 10.160 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Oral
  • Form: Unassigned
Reactions Reported:
Lameness Wobbliness Tiredness (lethargy) Unable to walk Weakness Fever Immune-mediated polyarthritis Gastritis Abdominal cavity disorder NOS Abnormal ultrasound finding Hyperproteinaemia Lymphopenia Eosinopenia Medication error NOS
Outcomes: Ongoing

Dog, Male, 12 year, 4.536 kilogram • Drug: MSK, Tablet, Oral, Dose: 100 Milligram per dose, Frequency: 12 per hour • Reactions: Lateral recumbency, Agonal breathing, Death • Outcome: Died

  • Report ID: USA-USFDACVM-2026-US-013917
  • Serious AE: Yes
  • Treated For AE: No
  • Sex: Male
  • Age: 12.00 Year
  • Weight: 4.536 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Oral
  • Form: Tablet
  • Dose: 100 Milligram per dose
  • Frequency: 12 per hour
Reactions Reported:
Lateral recumbency Agonal breathing Death
Outcomes: Died

Dog, Retriever - Labrador, Female, 12 year, 33.11 kilogram • Drug: MSK, Unknown • Reactions: Thrombocytopenia, Tiredness (lethargy) • Outcome: Outcome Unknown

  • Report ID: USA-USFDACVM-2026-US-014118
  • Serious AE: No
  • Treated For AE: No
  • Sex: Female
  • Age: 12.00 Year
  • Weight: 33.110 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Unknown
Reactions Reported:
Thrombocytopenia Tiredness (lethargy)
Outcomes: Outcome Unknown

Dog, Setter - English, Male, 9 year, 21.772 kilogram • Drug: MSK, Unassigned, Oral • Reactions: Dilated renal pelvis, Intestinal thickening, Abnormal ultrasound finding, Bradycardia, Pale mucous membrane… • Outcome: Ongoing

  • Report ID: USA-USFDACVM-2026-US-012782
  • Serious AE: Yes
  • Treated For AE: Yes
  • Sex: Male
  • Age: 9.00 Year
  • Weight: 21.772 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Oral
  • Form: Unassigned
Reactions Reported:
Dilated renal pelvis Intestinal thickening Abnormal ultrasound finding Bradycardia Pale mucous membrane Diarrhea Weight loss Tiredness (lethargy) Lymphoma Medication error NOS
Outcomes: Ongoing

Dog, ['Shepherd Dog - German', 'Dog (unknown)'], Male, 13 year, 31.842 kilogram • Drug: MSK, Unknown • Reactions: Vomiting, Reluctant to move, Unable to rise, Difficulty to rise, Weakness… • Outcome: Ongoing

  • Report ID: USA-USFDACVM-2026-US-013316
  • Serious AE: Yes
  • Treated For AE: Yes
  • Sex: Male
  • Age: 13.00 Year
  • Weight: 31.842 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Unknown
Reactions Reported:
Vomiting Reluctant to move Unable to rise Difficulty to rise Weakness Not eating Not drinking Heavy breathing Panting Tiredness (lethargy) Increased heart rate Increased respiratory rate Abdominal discomfort Dehydration Leukocytosis NOS Monocytosis Abnormal ultrasound finding
Outcomes: Ongoing

Dog, ['Retriever - Golden', 'Poodle (unspecified)'], Male, 3 year, 16.783 kilogram • Drug: MSK, Unassigned, Unknown • Reactions: Vomiting, Swelling around eye, Whining, Uncomfortable, Fever… • Outcome: Ongoing

  • Report ID: USA-USFDACVM-2026-US-012837
  • Serious AE: Yes
  • Treated For AE: Yes
  • Sex: Male
  • Age: 3.00 Year
  • Weight: 16.783 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Unknown
  • Form: Unassigned
Reactions Reported:
Vomiting Swelling around eye Whining Uncomfortable Fever Injected sclera Pinnal erythema Hypersensitivity reaction
Outcomes: Ongoing

Cat, Domestic Shorthair, Male, 12 year, 9.253 kilogram • Drug: MSK, Unassigned, Unknown • Reactions: Peripheral neuropathy, Plantigrade posture • Outcome: Ongoing

  • Report ID: USA-USFDACVM-2026-US-011901
  • Serious AE: No
  • Treated For AE: No
  • Sex: Male
  • Age: 12.00 Year
  • Weight: 9.253 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Unknown
  • Form: Unassigned
Reactions Reported:
Peripheral neuropathy Plantigrade posture
Outcomes: Ongoing

Data source: FDA openFDA Animal & Veterinary adverse event reports.

Overdose Information

No approved overdose-management text is linked yet. If overdose is suspected, contact a veterinarian or emergency clinic immediately.

Storage & Handling

Store at room temperature.

Share Your Thoughts

Let others know your experience or advice regarding this medication.

This medication has not been reviewed by a veterinarian yet.