Roxee Medication Guide

Metronidazole

Medication reference facts with explicit FDA-approval, off-label, source-limited, and safety context. Roxee does not sell, prescribe, or dispense medications.

Both Reference complete FDA data linked Rx required Suspension Multiple FDA labelers Official label facts Owner quick guide first

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Data freshness

Reference facts

Reference refreshed

Jun 22, 2026, 10:41 a.m.

These are the reference facts Roxee uses on browse cards and quick facts.

FDA applications

FDA application data refreshed

Jun 22, 2026, 10:41 a.m.

Sponsor, product, and application records imported from Animal Drugs @ FDA.

Safety reports

Safety data refreshed

Jun 21, 2026, 5:14 a.m.

openFDA reaction terms and case summaries are supporting evidence, not proof of causality.

Source timing details

Reference facts: Source Roxee | Refreshed Jun 22, 2026, 10:41 AM UTC
The reference fact projection used for browse cards and quick facts.
Animal Drugs @ FDA: Source FDA | Refreshed Jun 22, 2026, 10:40 AM UTC
Applications/products are imported from FDA export data.
Animal Drugs @ FDA previews: Source FDA | Refreshed Feb 9, 2026, 3:05 AM UTC
Label highlights/doc links are fetched from FDA preview endpoints.
Animal Drug Product Listing Directory (NDC): Source FDA | Refreshed Jun 22, 2026, 10:41 AM UTC
Package/product NDCs from FDA’s electronic listing directory (XLS).
openFDA reaction terms: Source FDA openFDA | Refreshed Jun 22, 2026, 10:45 AM UTC
openFDA case summaries: Source FDA openFDA | Refreshed Jun 22, 2026, 10:45 AM UTC

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Metronidazole

Drug type: Generic ingredient • Branded profile • FDA branded products available

Both Suspension Rx required 100% reference complete

Species: Both

Manufacturer: Multiple FDA labelers

Medication Snapshot

Merged from the current Roxee medication system with field-level provenance, freshness, and completeness tracking.

Metronidazole

Antibiotic/antiprotozoal used for certain GI infections and inflammation. Species commonly shown: Both, Dog.

Generic name

Metronidazole

Brand names

AYRADIA™, AYRADIA, Metronidazole, MetroCleanse

Manufacturer

Multiple FDA labelers

Species

Both, Dog

Dosage forms

Suspension

Prescription

Prescription required

Completeness

100%

Validation

Complete

Brand names

AYRADIA™ AYRADIA Metronidazole MetroCleanse Metroplex

Dosage forms

Suspension

Indications / Uses

Antibiotic/antiprotozoal used for certain GI infections and inflammation.

Administration / How To Give

Oral

Storage

Store at room temperature.

Warnings / Contraindications

Use caution with liver disease. Avoid overdosing.

Use caution with liver disease. Avoid overdosing.

Side Effects

GI upset. High doses can cause neurologic signs (ataxia, tremors).

FAQ

Both, Dog

Yes. Roxee shows this as prescription-only.

Suspension

Store at room temperature.

Related Medications

Source Transparency

Verified source: https://www.roxee.ai/meds/
Verified source: https://animaldrugsatfda.fda.gov
Verified source: https://animaldrugsatfda.fda.gov/adafda/views/#/search
Verified source: https://api.fda.gov/animalandveterinary/event.json
Verified source: https://www.accessdata.fda.gov/spl/data/d6dba729-3730-4bb7-9e77-b08b55714381/d6dba729-3730-4bb7-9e77-b08b55714381.xml
Verified source: https://www.accessdata.fda.gov/spl/data/20bc9eaf-eaa1-4ab0-8e91-377a0dc7847e/20bc9eaf-eaa1-4ab0-8e91-377a0dc7847e.xml
Last refreshed: Jun 22, 2026, 10:41 a.m.
Last verified: Feb 12, 2026, 7:40 p.m.
Validation status: Complete

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Pet Owner Quick Guide

Start here first for the safest next-step summary before the deeper medication detail.

Used for:

For the treatment of Giardia duodenalis infection in dogs.

Dosing note:

Exact dosing depends on your pet's species, weight, and health status. Use your veterinarian's instructions for the exact dose and schedule.

What to watch for:

Use caution with liver disease
Avoid overdosing
wobbly/unsteady walking (1 reports)
Decreased mean corpuscular volume (1 reports)
Decreased mean corpuscular haemoglobin concentration (1 reports)

When to call the vet:

Repeated vomiting or diarrhea.
Severe lethargy (hard to wake, very low energy).
Collapse or fainting.
Trouble breathing.
Facial swelling or hives.
Blood in vomit or stool.

What to tell or ask your vet today:

Is this medicine the right fit for my pet’s current symptoms?
Which warning signs mean I should call back right away?
How should I handle missed doses or refusal to take the medicine?

Next actions

Talk to a Vet / Find a Vet Near You Save to pet meds Share page Review report evidence

Research brief

Medication Research Insights

A source-aware map of what to know, what is uncertain, and what to verify with your veterinarian.

Source Backed Signals

What to know

Evidence-backed context Limited

Roxee has limited cited overview evidence for Metronidazole; use the official documents and your veterinarian's instructions for product-specific decisions.

Source: openFDA case USA-USFDACVM-2025-US-067364

Safety signal coverage Reported signals

32 tracked reaction signals; 32 reported cases; 20 serious reports; 2 species groups. These are reporting and label-derived signals for interpretation with a veterinarian.

Source: openFDA case USA-USFDACVM-2025-US-067364

Interpretation guardrail Not causation

Adverse-event reports help form a watch list, but they do not prove the medication caused the reaction and they are not a risk ranking between medications.

Evidence tension

Stronger signal Label / review

Official labels, package inserts, and reviewed summaries carry more weight than isolated reports.

Source: openFDA case USA-USFDACVM-2025-US-067364

Weaker signal Reported data

Case reports and openFDA terms are useful for pattern awareness, but they are incomplete, can include multiple exposures, and do not estimate an individual pet's probability of harm.

Reaction signal map

Most reported reactions Top terms

Unsteady walking (ataxia) (1 reports), Decreased mean corpuscular volume (1 reports), Decreased mean corpuscular haemoglobin concentration (1 reports), Decreased haemoglobin (1 reports), Decreased drinking (1 reports)

Body systems represented Signal grouping

Digestive (2), Skin & allergy (1), Neurologic (1), Behavior (2)

Explore supporting adverse reports

Species and breed lens

Species represented in reports Species lens

Dog (19 reports), Cat (13 reports)

Breed metadata in reports Metadata only

Terrier - Bull - American Pit (2), Domestic Shorthair (1), Cattle Dog - Australian (blue heeler, red heeler, Queensland cattledog) (1), ['Chihuahua', 'Mixed (Dog)'] (1). These are report metadata, not proof that a breed is at higher risk.

What your vet may verify

Fit for this patient Vet check

Verify whether Metronidazole fits the pet's species, current diagnosis, age, weight, organ status, pregnancy/lactation status, and concurrent medications.

Evidence limitations Evidence review

Separate label-backed warnings from adverse-event reports and owner observations before changing the plan.

What to watch next

Watch list Owner-safe

Use caution with liver disease, Avoid overdosing, wobbly/unsteady walking, Decreased mean corpuscular volume, Decreased mean corpuscular haemoglobin concentration

Call sooner if Escalation

Repeated vomiting or diarrhea. Severe lethargy (hard to wake, very low energy). Collapse or fainting.

Bottom line: Use this Metronidazole brief as a structured watch list and source map, not as a reason to start, stop, or change treatment without your veterinarian.

Vet source depth

openFDA case USA-USFDACVM-2025-US-067364 · adverse_reaction · adverse reactions
Contraindication source · fda_animal_drugs · warnings contraindications
FDA application profile · official_label · quick facts
Medication usage source · fda_animal_drugs · quick facts
FOI · document · documents
SPL · document · documents
Structured Product Label · document · documents
Structured Product Label · document · documents

Evidence

Review status / Updated / Sources

Review status: Clinical reviewer not listed

Updated: February 12, 2026, 7:40 PM UTC

Sources:

FDA application profile · official_label
Medication usage source · fda_animal_drugs
openFDA case USA-USFDACVM-2025-US-067364 · adverse_reaction
FOI · document
SPL · document

Safety & side effects

Side effects to monitor:

Use caution with liver disease
Avoid overdosing
wobbly/unsteady walking
Decreased mean corpuscular volume
Decreased mean corpuscular haemoglobin concentration

Most reported reactions:

Unsteady walking (ataxia) (1 reports)
Decreased mean corpuscular volume (1 reports)
Decreased mean corpuscular haemoglobin concentration (1 reports)

Explore reported case details

Emergency warning signs:

Repeated vomiting or diarrhea.
Severe lethargy (hard to wake, very low energy).
Collapse or fainting.
Trouble breathing.

Talk to a Vet / Find a Vet Near You Start Symptom Intake

Vet Fast Scan

Source-backed clinical checkpoints for quick review.

FDA-labeled species

Dog

Indication / use

For the treatment of Giardia duodenalis infection in dogs.

Form / route / dose

Form: Suspension
Route: Oral
Confirm product label and patient-specific plan.

Warnings

High: Use caution with liver disease. Avoid overdosing.

Adverse-event caveat

openFDA adverse-event cases are reported signals. They are not verified, do not prove causation, and do not estimate a pet's individual risk.

Source docs

Quick Facts

Official label facts first, then secondary summaries. Marketing content is separated below.

Species: Both

Manufacturer: Multiple FDA labelers

Form: Suspension

Identifiers:

NADA: 141572 NDC Package: 17163-015-16 NDC Package: 17163-016-17 NDC Package: 43457-537-25 NDC Package: 46144-602-01 NDC Package: 51311-034-10 NDC Package: 51311-034-30 NDC Package: 53745-016-01 NDC Package: 53745-016-02 NDC Package: 55999-081-12 NDC Package: 55999-081-15 NDC Package: 55999-081-18 NDC Package: 55999-081-56 NDC Package: 55999-081-57 NDC Package: 62157-529-01 NDC Package: 63732-2047-9 NDC Package: 73309-199-01 NDC Package: 86184-255-01 NDC Product: 17163 NDC Product: 43457

Source metadata:

https://animaldrugsatfda.fda.gov/adafda/views/#/home/previewsearch/141572 · official_label · FDA application profile
https://animaldrugsatfda.fda.gov · fda_animal_drugs · Medication usage source

Warnings / Contraindications

Use caution with liver disease. Avoid overdosing.

High: Use caution with liver disease. Avoid overdosing.

Source metadata:

https://animaldrugsatfda.fda.gov · fda_animal_drugs · Contraindication source

Adverse Reactions

Snapshot first, detailed rows second. This section summarizes signal data and is not a diagnosis.

Reported case explorer

Filter stored openFDA reports by pet and report attributes. Counts describe reports in this data set, not risk.

Clear filters

openFDA adverse-event cases are reported signals. They are not verified, do not prove causation, and do not estimate a pet's individual risk.

Stored reports

Matching reports

Active filters

Selected filters

Reaction: Elevated alanine aminotransferase (ALT) Clear Body system: Neurologic Clear

Species

Breed

Size / weight

Age

Sex

Seriousness

Outcome

Reaction

Body system

Region

Received after

Received before

Reset

Drill into common report signals

Lethargy (see also Central nervous system depression in Neurological) (7) Diarrhoea (5) Decreased appetite (4) Elevated alanine aminotransferase (ALT) (4) Other (21) Digestive (10) Neurologic (8) Effectiveness (3)

Showing up to 50 matching reports.

USA-USFDACVM-2025-US-072729

Received 2025-12-05 · MSK · MSK

Non-serious

Species: Dog
Breed: Terrier - Bull
Size / weight: 25-49 lb (17.6 Kilogram)
Age: 4-7 years (7 Year)
Sex: Female Neutered
Region: USA
Reactions: Leucopenia NOSAnaemia NOSHypoalbuminaemiaNeutropeniaPyodermaReduced globulinsHypophosphataemiaNon-regenerative anaemiaLow serum alkaline phosphatase (ALP)Pale mucous membraneElevated alanine aminotransferase (ALT)Decreased packed cell volume (PCV)Lethargy (see also Central nervous system depression in Neurological)HypocalcaemiaElevated aspartate aminotransferase (AST)HypoproteinaemiaProteinuriaElectrolyte disorderDisorder of red blood cell NOSElevated creatine-kinase (CK)Other coagulation investigation abnormalityIncreased band neutrophiliaElevated mean corpuscular volume (MCV)LymphopeniaOther abnormal test result NOSDiarrhoeaPanleucopeniaEosinopeniaDecreased haematocritIncreased percentage reticulocytes
Body systems: OtherNeurologicDigestive
Outcomes: Ongoing

USA-USFDACVM-2025-US-072504

Received 2025-12-04 · MSK · MSK

Serious

Species: Dog
Breed: Terrier - Bull - American Pit
Size / weight: 50-99 lb (29.03 Kilogram)
Age: 1-3 years (2 Year)
Sex: Male Neutered
Region: USA
Reactions: Otitis externaTrigeminus paralysisVomitingCoughMuscle atrophy (see also Muscle wasting)Elevated serum alkaline phosphatase (ALP)Elevated alanine aminotransferase (ALT)HypersalivationUnusual stool colourErythema (for urticaria see Immune SOC)Elevated gamma-glutamyl transferase (GGT)Elevated total bilirubinAbnormal ultrasound findingHepatic fibrosisHepatitisLethargy (see also Central nervous system depression in Neurological)AngioedemaGeneralised rashDyspnoeaIncreased lung soundsLeucocytosis NOSIcterusAbnormal radiograph findingJaw disorder
Body systems: OtherDigestiveSkin & allergyNeurologic
Outcomes: Ongoing

Tap or hover a reaction to see what it means in plain language.

Tracked signals

Reported cases

Serious reports

Species represented

Grouped by Body System

Digestive (2) · Decreased appetite, Bloody diarrhoea Skin & allergy (1) · Application site hair loss Neurologic (1) · Unsteady walking (ataxia) Behavior (2) · Circling - behavioural disorder, Behavioral disorder (unspecified) Other (26) · Decreased packed cell volume, Decreased mean corpuscular volume, Decreased mean corpuscular haemoglobin concentration

Most Reported Reactions

Body system	Cases	Species	Serious cases
Neurologic	1	Cat	1
Other	1	Cat	1
Other	1	Cat	1
Other	1	Cat	1
Other	1	Dog	1
Other	1	Dog	1
Other	1	Dog	1
Digestive	1	Cat	1

Species coverage: Dog (19) Cat (13)

View detailed reaction table

Body system	Species	Seriousness	Frequency	Reports
Neurologic	Cat	Serious	-	1
Other	Dog	Non-serious	-	1
Other	Cat	Serious	-	1
Other	Cat	Serious	-	1
Other	Cat	Serious	-	1
Other	Dog	Non-serious	-	1
Other	Dog	Serious	-	1
Other	Dog	Serious	-	1
Other	Dog	Serious	-	1
Digestive	Cat	Serious	-	1
Other	Dog	Serious	-	1
Other	Cat	Serious	-	1
Other	Dog	Serious	-	1
Other	Cat	Serious	-	1
Other	Dog	Serious	-	1
Behavior	Dog	Non-serious	-	1
Other	Dog	Serious	-	1
Other	Dog	Non-serious	-	1
Digestive	Dog	Serious	-	1
Other	Cat	Serious	-	1
Other	Dog	Non-serious	-	1
Behavior	Cat	Non-serious	-	1
Other	Dog	Non-serious	-	1
Other	Cat	Non-serious	-	1
Skin & allergy	Cat	Non-serious	-	1
Other	Cat	Non-serious	-	1
Other	Dog	Serious	-	1
Other	Dog	Non-serious	-	1
Other	Dog	Non-serious	-	1
Other	Dog	Serious	-	1
Other	Dog	Serious	-	1
Other	Cat	Serious	-	1

Source metadata:

https://api.fda.gov/animalandveterinary/event.json · adverse_reaction · openFDA case USA-USFDACVM-2025-US-067364

Storage & Handling

Store at room temperature.

Source Documents

The most useful source links appear first; full previews and metadata stay in the veterinary/professional layer.

Use original documents to confirm product-specific warnings, ingredients, and handling details with your veterinarian.

AYRADIA™ SPL · SPL METRONIDAZOLE SPL SPL · Structured Product Label Metronidazole SPL SPL · Structured Product Label

Full source previews and metadata remain in the veterinary/professional layer.

Owner handouts

No owner handouts linked yet.

Official label / PI

No official label or package insert links yet.

SPL

FOI

AYRADIA™

SPL · SPL

Open original

FDA Structured Product Label

AYRADIA™

Rendered from Roxee's cached FDA SPL package contents for on-page reading. Use Open original for the raw FDA ZIP/XML source.

Sponsor: Virbac AH, Inc.
NADA: 141-572
Status: RX
Form: Suspension
Route: Oral
Species: Dog

Composition / specifications

125 mg/mL

Dogs

Indication

For the treatment of Giardia duodenalis infection in dogs.

Dosage

25 mg/kg (11.3 mg/lb) of body weight, using the supplied syringe, twice daily for five consecutive days