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Roxee Medication Guide

Metronidazole

Medication reference facts with explicit FDA-approval, off-label, source-limited, and safety context. Roxee does not sell, prescribe, or dispense medications.

Both Reference complete FDA data linked Rx required Suspension Multiple FDA labelers Official label facts Owner quick guide first
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Data freshness

Reference facts
Reference refreshed
Jun 22, 2026, 10:41 a.m.

These are the reference facts Roxee uses on browse cards and quick facts.

FDA applications
FDA application data refreshed
Jun 22, 2026, 10:41 a.m.

Sponsor, product, and application records imported from Animal Drugs @ FDA.

Safety reports
Safety data refreshed
Jun 21, 2026, 5:14 a.m.

openFDA reaction terms and case summaries are supporting evidence, not proof of causality.

Source timing details
Source timing details
  • Reference facts: Source Roxee | Refreshed Jun 22, 2026, 10:41 AM UTC
    The reference fact projection used for browse cards and quick facts.
  • Animal Drugs @ FDA: Source FDA | Refreshed Jun 22, 2026, 10:40 AM UTC
    Applications/products are imported from FDA export data.
  • Animal Drugs @ FDA previews: Source FDA | Refreshed Feb 9, 2026, 3:05 AM UTC
    Label highlights/doc links are fetched from FDA preview endpoints.
  • Animal Drug Product Listing Directory (NDC): Source FDA | Refreshed Jun 22, 2026, 10:41 AM UTC
    Package/product NDCs from FDA’s electronic listing directory (XLS).
  • openFDA reaction terms: Source FDA openFDA | Refreshed Jun 22, 2026, 10:45 AM UTC
  • openFDA case summaries: Source FDA openFDA | Refreshed Jun 22, 2026, 10:45 AM UTC
Image coming soon
Metronidazole

Metronidazole

Drug type: Generic ingredient • Branded profile • FDA branded products available

Both Suspension Rx required 100% reference complete

Species: Both

Manufacturer: Multiple FDA labelers

Medication Snapshot

Merged from the current Roxee medication system with field-level provenance, freshness, and completeness tracking.

Metronidazole

Antibiotic/antiprotozoal used for certain GI infections and inflammation. Species commonly shown: Both, Dog.

Generic name
Metronidazole
Brand names
AYRADIA™, AYRADIA, Metronidazole, MetroCleanse
Manufacturer
Multiple FDA labelers
Species
Both, Dog
Dosage forms
Suspension
Prescription
Prescription required
Completeness
100%
Validation
Complete
Brand names
AYRADIA™ AYRADIA Metronidazole MetroCleanse Metroplex
Dosage forms
Suspension

Indications / Uses

Antibiotic/antiprotozoal used for certain GI infections and inflammation.

Administration / How To Give

Oral

Storage

Store at room temperature.

Warnings / Contraindications

Use caution with liver disease. Avoid overdosing.

  • Use caution with liver disease. Avoid overdosing.

Side Effects

GI upset. High doses can cause neurologic signs (ataxia, tremors).

FAQ

Both, Dog

Yes. Roxee shows this as prescription-only.

Suspension

Store at room temperature.

Related Medications

Amoxicillin-Clavulanate Same category: Antibiotics Cefovecin Same category: Antibiotics Cephalexin Same category: Antibiotics Enrofloxacin Same category: Antibiotics Ivermectin, Pyrantel Same category: Antibiotics Melarsomine Dihydrochloride Same category: Antibiotics

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Pet Owner Quick Guide

Start here first for the safest next-step summary before the deeper medication detail.

Used for:

For the treatment of Giardia duodenalis infection in dogs.

Dosing note:

Exact dosing depends on your pet's species, weight, and health status. Use your veterinarian's instructions for the exact dose and schedule.

What to watch for:

  • Use caution with liver disease
  • Avoid overdosing
  • wobbly/unsteady walking (1 reports)
  • Decreased mean corpuscular volume (1 reports)
  • Decreased mean corpuscular haemoglobin concentration (1 reports)

When to call the vet:

  • Repeated vomiting or diarrhea.
  • Severe lethargy (hard to wake, very low energy).
  • Collapse or fainting.
  • Trouble breathing.
  • Facial swelling or hives.
  • Blood in vomit or stool.

What to tell or ask your vet today:

  • Is this medicine the right fit for my pet’s current symptoms?
  • Which warning signs mean I should call back right away?
  • How should I handle missed doses or refusal to take the medicine?

Next actions

Talk to a Vet / Find a Vet Near You Save to pet meds Share page Review report evidence
Research brief

Medication Research Insights

A source-aware map of what to know, what is uncertain, and what to verify with your veterinarian.

Source Backed Signals

What to know

Evidence-backed context Limited

Roxee has limited cited overview evidence for Metronidazole; use the official documents and your veterinarian's instructions for product-specific decisions.

Source: openFDA case USA-USFDACVM-2025-US-067364
Safety signal coverage Reported signals

32 tracked reaction signals; 32 reported cases; 20 serious reports; 2 species groups. These are reporting and label-derived signals for interpretation with a veterinarian.

Source: openFDA case USA-USFDACVM-2025-US-067364
Interpretation guardrail Not causation

Adverse-event reports help form a watch list, but they do not prove the medication caused the reaction and they are not a risk ranking between medications.

Evidence tension

Stronger signal Label / review

Official labels, package inserts, and reviewed summaries carry more weight than isolated reports.

Source: openFDA case USA-USFDACVM-2025-US-067364
Weaker signal Reported data

Case reports and openFDA terms are useful for pattern awareness, but they are incomplete, can include multiple exposures, and do not estimate an individual pet's probability of harm.

Reaction signal map

Most reported reactions Top terms

Unsteady walking (ataxia) (1 reports), Decreased mean corpuscular volume (1 reports), Decreased mean corpuscular haemoglobin concentration (1 reports), Decreased haemoglobin (1 reports), Decreased drinking (1 reports)

Body systems represented Signal grouping

Digestive (2), Skin & allergy (1), Neurologic (1), Behavior (2)

Explore supporting adverse reports

Species and breed lens

Species represented in reports Species lens

Dog (19 reports), Cat (13 reports)

Breed metadata in reports Metadata only

Terrier - Bull - American Pit (2), Domestic Shorthair (1), Cattle Dog - Australian (blue heeler, red heeler, Queensland cattledog) (1), ['Chihuahua', 'Mixed (Dog)'] (1). These are report metadata, not proof that a breed is at higher risk.

What your vet may verify

Fit for this patient Vet check

Verify whether Metronidazole fits the pet's species, current diagnosis, age, weight, organ status, pregnancy/lactation status, and concurrent medications.

Evidence limitations Evidence review

Separate label-backed warnings from adverse-event reports and owner observations before changing the plan.

What to watch next

Watch list Owner-safe

Use caution with liver disease, Avoid overdosing, wobbly/unsteady walking, Decreased mean corpuscular volume, Decreased mean corpuscular haemoglobin concentration

Call sooner if Escalation

Repeated vomiting or diarrhea. Severe lethargy (hard to wake, very low energy). Collapse or fainting.

Bottom line: Use this Metronidazole brief as a structured watch list and source map, not as a reason to start, stop, or change treatment without your veterinarian.
Vet source depth
  1. openFDA case USA-USFDACVM-2025-US-067364 · adverse_reaction · adverse reactions
  2. Contraindication source · fda_animal_drugs · warnings contraindications
  3. FDA application profile · official_label · quick facts
  4. Medication usage source · fda_animal_drugs · quick facts
  5. FOI · document · documents
  6. SPL · document · documents
  7. Structured Product Label · document · documents
  8. Structured Product Label · document · documents

Evidence

Review status / Updated / Sources

Review status: Clinical reviewer not listed

Updated: February 12, 2026, 7:40 PM UTC

Sources:
Safety & side effects

Side effects to monitor:

  • Use caution with liver disease
  • Avoid overdosing
  • wobbly/unsteady walking
  • Decreased mean corpuscular volume
  • Decreased mean corpuscular haemoglobin concentration

Most reported reactions:

  • Unsteady walking (ataxia) (1 reports)
  • Decreased mean corpuscular volume (1 reports)
  • Decreased mean corpuscular haemoglobin concentration (1 reports)
Explore reported case details

Emergency warning signs:

  • Repeated vomiting or diarrhea.
  • Severe lethargy (hard to wake, very low energy).
  • Collapse or fainting.
  • Trouble breathing.
Talk to a Vet / Find a Vet Near You Start Symptom Intake

Vet Fast Scan

Source-backed clinical checkpoints for quick review.

FDA-labeled species
Dog
Indication / use
For the treatment of Giardia duodenalis infection in dogs.
Form / route / dose
Form: Suspension
Route: Oral
Confirm product label and patient-specific plan.
Warnings
  • High: Use caution with liver disease. Avoid overdosing.
Adverse-event caveat
openFDA adverse-event cases are reported signals. They are not verified, do not prove causation, and do not estimate a pet's individual risk.
Source docs

Quick Facts

Official label facts first, then secondary summaries. Marketing content is separated below.

Species: Both
Manufacturer: Multiple FDA labelers
Form: Suspension
Identifiers:
NADA: 141572 NDC Package: 17163-015-16 NDC Package: 17163-016-17 NDC Package: 43457-537-25 NDC Package: 46144-602-01 NDC Package: 51311-034-10 NDC Package: 51311-034-30 NDC Package: 53745-016-01 NDC Package: 53745-016-02 NDC Package: 55999-081-12 NDC Package: 55999-081-15 NDC Package: 55999-081-18 NDC Package: 55999-081-56 NDC Package: 55999-081-57 NDC Package: 62157-529-01 NDC Package: 63732-2047-9 NDC Package: 73309-199-01 NDC Package: 86184-255-01 NDC Product: 17163 NDC Product: 43457
Source metadata:

Warnings / Contraindications

Use caution with liver disease. Avoid overdosing.

  • High: Use caution with liver disease. Avoid overdosing.
Source metadata:

Adverse Reactions

Snapshot first, detailed rows second. This section summarizes signal data and is not a diagnosis.

Reported case explorer

Filter stored openFDA reports by pet and report attributes. Counts describe reports in this data set, not risk.

Clear filters
openFDA adverse-event cases are reported signals. They are not verified, do not prove causation, and do not estimate a pet's individual risk.
Stored reports
21
Matching reports
4
Active filters
2
Selected filters
Reaction: Elevated alanine aminotransferase (ALT) Clear Body system: Other Clear
Reset
Drill into common report signals
Lethargy (see also Central nervous system depression in Neurological) (7) Diarrhoea (5) Decreased appetite (4) Elevated alanine aminotransferase (ALT) (4) Other (21) Digestive (10) Neurologic (8) Effectiveness (3)
Showing up to 50 matching reports.

USA-USFDACVM-2025-US-073969

Received 2025-12-11 · MSK · MSK

Serious
Species
Dog
Breed
['Chihuahua', 'Mixed (Dog)']
Size / weight
Under 10 lb (2.268 Kilogram)
Age
4-7 years (7 Year)
Sex
Male Neutered
Region
USA
Reactions
ObtundedHypothermiaHypotensionHypoglycaemiaCardiorespiratory arrestProlonged one stage prothrombin time (OSPT)HyperphosphataemiaHypercalcaemiaElevated alanine aminotransferase (ALT)Elevated aspartate aminotransferase (AST)HypoproteinaemiaHypoalbuminaemiaReduced globulinsDecreased cholesterol (total)ThrombocytopeniaHaematocheziaRegurgitationDeath by euthanasiaLateral recumbencyDehydration
Body systems
Other
Outcomes
Euthanized

USA-USFDACVM-2025-US-072729

Received 2025-12-05 · MSK · MSK

Non-serious
Species
Dog
Breed
Terrier - Bull
Size / weight
25-49 lb (17.6 Kilogram)
Age
4-7 years (7 Year)
Sex
Female Neutered
Region
USA
Reactions
Leucopenia NOSAnaemia NOSHypoalbuminaemiaNeutropeniaPyodermaReduced globulinsHypophosphataemiaNon-regenerative anaemiaLow serum alkaline phosphatase (ALP)Pale mucous membraneElevated alanine aminotransferase (ALT)Decreased packed cell volume (PCV)Lethargy (see also Central nervous system depression in Neurological)HypocalcaemiaElevated aspartate aminotransferase (AST)HypoproteinaemiaProteinuriaElectrolyte disorderDisorder of red blood cell NOSElevated creatine-kinase (CK)Other coagulation investigation abnormalityIncreased band neutrophiliaElevated mean corpuscular volume (MCV)LymphopeniaOther abnormal test result NOSDiarrhoeaPanleucopeniaEosinopeniaDecreased haematocritIncreased percentage reticulocytes
Body systems
OtherNeurologicDigestive
Outcomes
Ongoing

USA-USFDACVM-2025-US-072504

Received 2025-12-04 · MSK · MSK

Serious
Species
Dog
Breed
Terrier - Bull - American Pit
Size / weight
50-99 lb (29.03 Kilogram)
Age
1-3 years (2 Year)
Sex
Male Neutered
Region
USA
Reactions
Otitis externaTrigeminus paralysisVomitingCoughMuscle atrophy (see also Muscle wasting)Elevated serum alkaline phosphatase (ALP)Elevated alanine aminotransferase (ALT)HypersalivationUnusual stool colourErythema (for urticaria see Immune SOC)Elevated gamma-glutamyl transferase (GGT)Elevated total bilirubinAbnormal ultrasound findingHepatic fibrosisHepatitisLethargy (see also Central nervous system depression in Neurological)AngioedemaGeneralised rashDyspnoeaIncreased lung soundsLeucocytosis NOSIcterusAbnormal radiograph findingJaw disorder
Body systems
OtherDigestiveSkin & allergyNeurologic
Outcomes
Ongoing

USA-USFDACVM-2025-US-071623

Received 2025-12-01 · MSK · MSK

Serious
Species
Dog
Breed
['Retriever - Labrador', 'Dog (unknown)']
Size / weight
25-49 lb (17.69 Kilogram)
Age
8+ years (12 Year)
Sex
Male Neutered
Region
USA
Reactions
VomitingNot eatingWeight lossIcterusLeucopenia NOSDecreased red blood cell countThrombocytopeniaElevated alanine aminotransferase (ALT)Elevated serum alkaline phosphatase (ALP)Elevated total bilirubinHigh pancreatic-specific lipaseUrinary incontinenceInfectious disease NOSOverdoseGall bladder & bile duct disorder NOSLymphopeniaNeutropeniaSplenomegalyLoose stoolPancreas disorderHepatomegalyDeath by euthanasiaHypoalbuminaemiaHypoproteinaemiaFluid in abdomen NOSElevated blood urea nitrogen (BUN)Elevated bile acidsAbnormal ultrasound findingElevated cholesterol (total)Enlarged lymph node (localised)Reduced globulinsMonocytopeniaEosinopeniaLiver nodules
Body systems
DigestiveOther
Outcomes
Euthanized

Tap or hover a reaction to see what it means in plain language.

Tracked signals
32
Reported cases
32
Serious reports
20
Species represented
2
Grouped by Body System
Digestive (2) · Decreased appetite, Bloody diarrhoea Skin & allergy (1) · Application site hair loss Neurologic (1) · Unsteady walking (ataxia) Behavior (2) · Circling - behavioural disorder, Behavioral disorder (unspecified) Other (26) · Decreased packed cell volume, Decreased mean corpuscular volume, Decreased mean corpuscular haemoglobin concentration
Most Reported Reactions
Reaction Body system Cases Species Serious cases
Neurologic 1 Cat 1
Other 1 Cat 1
Other 1 Cat 1
Other 1 Cat 1
Other 1 Dog 1
Other 1 Dog 1
Other 1 Dog 1
Digestive 1 Cat 1

Species coverage: Dog (19) Cat (13)

View detailed reaction table
Reaction Body system Species Seriousness Frequency Reports
Neurologic Cat Serious - 1
Other Dog Non-serious - 1
Other Cat Serious - 1
Other Cat Serious - 1
Other Cat Serious - 1
Other Dog Non-serious - 1
Other Dog Serious - 1
Other Dog Serious - 1
Other Dog Serious - 1
Digestive Cat Serious - 1
Other Dog Serious - 1
Other Cat Serious - 1
Other Dog Serious - 1
Other Cat Serious - 1
Other Dog Serious - 1
Behavior Dog Non-serious - 1
Other Dog Serious - 1
Other Dog Non-serious - 1
Digestive Dog Serious - 1
Other Cat Serious - 1
Other Dog Non-serious - 1
Behavior Cat Non-serious - 1
Other Dog Non-serious - 1
Other Cat Non-serious - 1
Skin & allergy Cat Non-serious - 1
Other Cat Non-serious - 1
Other Dog Serious - 1
Other Dog Non-serious - 1
Other Dog Non-serious - 1
Other Dog Serious - 1
Other Dog Serious - 1
Other Cat Serious - 1
Source metadata:

Storage & Handling

Store at room temperature.

Source Documents

The most useful source links appear first; full previews and metadata stay in the veterinary/professional layer.

Use original documents to confirm product-specific warnings, ingredients, and handling details with your veterinarian.

AYRADIA™ SPL · SPL METRONIDAZOLE SPL SPL · Structured Product Label Metronidazole SPL SPL · Structured Product Label

Full source previews and metadata remain in the veterinary/professional layer.

Owner handouts

0
No owner handouts linked yet.

Official label / PI

0
No official label or package insert links yet.

SPL

6

FOI

1

AYRADIA™

SPL · SPL

Open original
FDA Structured Product Label

AYRADIA™

Rendered from Roxee's cached FDA SPL package contents for on-page reading. Use Open original for the raw FDA ZIP/XML source.

Sponsor
Virbac AH, Inc.
NADA
141-572
Status
RX
Form
Suspension
Route
Oral
Species
Dog
Composition / specifications
125 mg/mL

Dogs

Indication

For the treatment of Giardia duodenalis infection in dogs.

Dosage

25 mg/kg (11.3 mg/lb) of body weight, using the supplied syringe, twice daily for five consecutive days

METRONIDAZOLE SPL

SPL · Structured Product Label

Open original
FDA Structured Product Label XML for METRONIDAZOLE. Use the source link for the full official labeling record.

Metronidazole SPL

SPL · Structured Product Label

Open original
FDA Structured Product Label XML for Metronidazole. Use the source link for the full official labeling record.

AYRADIA SPL

SPL · Structured Product Label

Open original
FDA Structured Product Label XML for AYRADIA. Use the source link for the full official labeling record.

Metroplex SPL

SPL · Structured Product Label

Open original
FDA Structured Product Label XML for Metroplex. Use the source link for the full official labeling record.

MetroCleanse SPL

SPL · Structured Product Label

Open original
FDA Structured Product Label XML for MetroCleanse. Use the source link for the full official labeling record.

N-141572-G-0006-OT-AA_foi.pdf

FOI · FOI

Open original
Source metadata:
Veterinary reference (advanced)

Canonical medication sections are above. This legacy block remains available for deeper cross-reference without cluttering the primary workflow.

At a Glance

Quick facts and links to official labeling and safety signals.

Data freshness
  • Reference facts: Source Roxee | Refreshed Jun 22, 2026, 10:41 AM UTC
    The reference fact projection used for browse cards and quick facts.
  • Animal Drugs @ FDA: Source FDA | Refreshed Jun 22, 2026, 10:40 AM UTC
    Applications/products are imported from FDA export data.
  • Animal Drugs @ FDA previews: Source FDA | Refreshed Feb 9, 2026, 3:05 AM UTC
    Label highlights/doc links are fetched from FDA preview endpoints.
  • Animal Drug Product Listing Directory (NDC): Source FDA | Refreshed Jun 22, 2026, 10:41 AM UTC
    Package/product NDCs from FDA’s electronic listing directory (XLS).
  • openFDA reaction terms: Source FDA openFDA | Refreshed Jun 22, 2026, 10:45 AM UTC
  • openFDA case summaries: Source FDA openFDA | Refreshed Jun 22, 2026, 10:45 AM UTC
Official (FDA)
Identity: Generic ingredient • FDA branded products available
Official FDA brands: AYRADIA METRONIDAZOLE MetroCleanse Metronidazole Metroplex
Manufacturer mapping: Multiple FDA labelers
Case-reported brands (openFDA): MSK
Catalog species: Both • FDA-labeled species: Dog
Rx/OTC: RX
Form/route: Suspension • Oral
Applications: NADA 141-572
NDC: Packages 43457-537-25 51311-034-10 51311-034-30 53745-016-01 53745-016-02 55999-081-12 • Products 43457 51311 53745 55999 86184
Documents: 1 (FOI: 1) • SPL: 1 • Label highlights • Official documents
Safety (openFDA)
Top reactions: Dog 126 • Cat 64 • View
Case summaries: 21 (showing 8) • View
openFDA reports are unverified and do not prove causation.
Diagnosis Codes

Diagnosis-code mappings are not available for this medication yet.

Counseling and Monitoring Highlights

Global Pet owner/Vet mode is controlled in the header. This section avoids duplicate in-page persona tabs.

Owner-facing counseling points
  • Use caution with liver disease. Avoid overdosing. (Contraindication, High)
Top reaction signals
Unsteady walking (ataxia) (1) Decreased mean corpuscular volume (1) Decreased mean corpuscular haemoglobin concentration (1) Decreased haemoglobin (1) Decreased drinking (1) Decreased cholesterol (1) Decreased bowel movements (1) Decreased appetite (1)

Identifiers & Packages

Normalized identifiers (NDC/NADA/ANADA) and package metadata from regulator listings.

Identifiers
NADA: 141572 NDC Package: 17163-015-16 NDC Package: 17163-016-17 NDC Package: 43457-537-25 NDC Package: 46144-602-01 NDC Package: 51311-034-10 NDC Package: 51311-034-30 NDC Package: 53745-016-01 NDC Package: 53745-016-02 NDC Package: 55999-081-12 NDC Package: 55999-081-15 NDC Package: 55999-081-18 NDC Package: 55999-081-56 NDC Package: 55999-081-57 NDC Package: 62157-529-01 NDC Package: 63732-2047-9 NDC Package: 73309-199-01 NDC Package: 86184-255-01 NDC Product: 17163 NDC Product: 43457 NDC Product: 46144 NDC Product: 51311 NDC Product: 53745 NDC Product: 55999
Package NDC Product NDC Form / Route Status
17163-015-16 17163 -
17163-016-17 17163 -
43457-537-25 43457 -
46144-602-01 46144 -
51311-034-10 51311 -
51311-034-30 51311 -
53745-016-01 53745 -
53745-016-02 53745 -
55999-081-12 55999 -
55999-081-15 55999 -
55999-081-18 55999 -
55999-081-56 55999 -
55999-081-57 55999 -
62157-529-01 62157 -
63732-2047-9 63732 -
73309-199-01 73309 -
86184-255-01 86184 -

Enriched Documents

Documents are tiered by source trust: Official, Clinical, Manufacturer, Marketing.

  • METRONIDAZOLE SPL • Structured Product Label • Official
    FDA Structured Product Label from the electronic animal drug product listing directory.
  • Metronidazole SPL • Structured Product Label • Official
    FDA Structured Product Label from the electronic animal drug product listing directory.
  • AYRADIA SPL • Structured Product Label • Official
    FDA Structured Product Label from the electronic animal drug product listing directory.
  • Metroplex SPL • Structured Product Label • Official
    FDA Structured Product Label from the electronic animal drug product listing directory.
  • MetroCleanse SPL • Structured Product Label • Official
    FDA Structured Product Label from the electronic animal drug product listing directory.
  • N-141572-G-0006-OT-AA_foi.pdf • FOI summary • Official • March 26, 2024
    FDA FOI summary for application 141572

Data Sources & Change Log

Every non-trivial field is expected to include provenance and update timestamps.

Official 122 Clinical 4 Manufacturer 0 Marketing 0
Current Field Facts
  • side_effects: GI upset. High doses can cause neurologic signs (ataxia, tremors). (Clinical, 2026-04-11)
  • storage_handling: Store at room temperature. (Clinical, 2026-04-12)
  • storage_handling: Store at room temperature. (Clinical, 2026-04-11)
  • storage_handling: Store at room temperature. (Clinical, 2026-02-12)
  • contraindications: Use caution with liver disease. Avoid overdosing. (Official, 2026-04-12)
  • contraindications: Use caution with liver disease. Avoid overdosing. (Official, 2026-04-11)
  • contraindications: Use caution with liver disease. Avoid overdosing. (Official, 2026-02-12)
  • indications: For the treatment of Giardia duodenalis infection in dogs. (Official, 2026-06-22)
  • indications: For the treatment of Giardia duodenalis infection in dogs. (Official, 2026-06-22)
  • indications: For the treatment of Giardia duodenalis infection in dogs. (Official, 2026-06-21)
  • indications: For the treatment of Giardia duodenalis infection in dogs. (Official, 2026-06-20)
  • indications: For the treatment of Giardia duodenalis infection in dogs. (Official, 2026-06-13)
  • indications: For the treatment of Giardia duodenalis infection in dogs. (Official, 2026-06-12)
  • indications: For the treatment of Giardia duodenalis infection in dogs. (Official, 2026-06-12)
  • indications: For the treatment of Giardia duodenalis infection in dogs. (Official, 2026-06-11)
  • indications: For the treatment of Giardia duodenalis infection in dogs. (Official, 2026-06-11)
  • indications: For the treatment of Giardia duodenalis infection in dogs. (Official, 2026-06-10)
  • indications: For the treatment of Giardia duodenalis infection in dogs. (Official, 2026-06-09)
  • indications: For the treatment of Giardia duodenalis infection in dogs. (Official, 2026-06-08)
  • indications: For the treatment of Giardia duodenalis infection in dogs. (Official, 2026-06-07)
Recent Revisions
  • side_effects updated 2026-04-12 10:05 by etl_backfill • Backfilled from existing medication fields
  • contraindications updated 2026-04-12 10:05 by etl_backfill • Backfilled from existing medication fields
  • usage updated 2026-04-12 10:05 by etl_backfill • Backfilled from existing medication fields
  • side_effects updated 2026-04-11 10:05 by etl_backfill • Backfilled from existing medication fields
  • contraindications updated 2026-04-11 10:05 by etl_backfill • Backfilled from existing medication fields
  • usage updated 2026-04-11 10:05 by etl_backfill • Backfilled from existing medication fields
  • side_effects updated 2026-02-12 19:40 by etl_backfill • Backfilled from existing medication fields
  • contraindications updated 2026-02-12 19:40 by etl_backfill • Backfilled from existing medication fields
  • usage updated 2026-02-12 19:40 by etl_backfill • Backfilled from existing medication fields

FDA Products & Applications (Animal Drugs @ FDA)

Official sponsor/proprietary-name/application-status records linked by active ingredient.

Product Sponsor Application Status Published
AYRADIA™
RX
Metronidazole
Suspension • Oral
Label highlights
Official documents
Virbac AH, Inc. NADA 141-572 Approved Mar 26, 2024

Data source: FDA Animal Drugs @ FDA (public search export).

What It's For (FDA Label Highlights)

Extracted from FDA Animal Drugs @ FDA product labeling. Always confirm details with your veterinarian.

Species: Dog
Composition / specifications
125 mg/mL
Dogs
Indication

For the treatment of Giardia duodenalis infection in dogs.

Dosage

25 mg/kg (11.3 mg/lb) of body weight, using the supplied syringe, twice daily for five consecutive days

Limitations

FDA page: Open in Animal Drugs @ FDA

Usage

Antibiotic/antiprotozoal used for certain GI infections and inflammation.

Source: FDA Animal Drugs @ FDA • Reference

Contraindications

Use caution with liver disease. Avoid overdosing.

Side Effects

GI upset. High doses can cause neurologic signs (ataxia, tremors).

Source: FDA openFDA • Reference

Top Reported Reactions (openFDA)

De-duplicated reaction terms grouped by body system from FDA openFDA reports (not verified; does not prove causation).

Digestive
Decreased appetite (1) • Cat Bloody diarrhoea (1) • Dog

Showing top 5 for Digestive.

Skin & allergy
Application site hair loss (1) • Cat

Showing top 5 for Skin & allergy.

Neurologic
Unsteady walking (1) • Cat

Showing top 5 for Neurologic.

Behavior
Circling - behavioural disorder (1) • Dog Behavioral disorder (1) • Cat

Showing top 5 for Behavior.

Other
Decreased packed cell volume (1) • Dog Decreased mean corpuscular volume (1) • Cat Decreased mean corpuscular haemoglobin concentration (1) • Cat Decreased haemoglobin (1) • Cat Decreased haematocrit (1) • Dog
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Decreased drinking (1) • Dog Decreased cholesterol (1) • Dog Decreased bowel movements (1) • Dog Death by euthanasia (1) • Dog Death (1) • Cat Cough (1) • Dog Cold feeling to the touch (1) • Cat Cognitive disorder NOS (1) • Dog Cardiorespiratory arrest (1) • Dog Bloody stool (1) • Dog Blood in urine (1) • Cat Bilirubinuria (1) • Dog Barking (1) • Dog Application site reddening (1) • Cat Application site bleeding (1) • Cat Angioedema (1) • Dog Anaemia NOS (1) • Dog Agitation (1) • Dog Abnormal ultrasound finding (1) • Dog Abnormal stool colouration (1) • Dog Abnormal radiograph finding (1) • Cat

Showing top 5 for Other.

Data source: FDA openFDA Animal & Veterinary adverse event reports.

Adverse Event Case Summaries (openFDA)

These are individual FDA adverse event reports. They are unverified and do not prove the medication caused the reaction.

Cat, Domestic Shorthair, Male, 9.5 year, 5.09 kilogram • Drug: MSK, Oral • Reactions: Application site hair loss, Application site bleeding, Application site reddening • Outcome: Outcome Unknown

  • Report ID: USA-USFDACVM-2025-US-075004
  • Serious AE: No
  • Treated For AE: No
  • Sex: Male
  • Age: 9.50 Year
  • Weight: 5.090 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Oral
Reactions Reported:
Application site hair loss Application site bleeding Application site reddening
Outcomes: Outcome Unknown

Dog, Terrier - Bull - American Pit, Male, 7 year, 37 kilogram • Drug: MSK, Unassigned, Unknown • Reactions: Loose stool, Vomiting, Decreased appetite, Decreased drinking, Medication error NOS… • Outcome: Ongoing

  • Report ID: USA-USFDACVM-2025-US-073901
  • Serious AE: Yes
  • Treated For AE: Yes
  • Sex: Male
  • Age: 7.00 Year
  • Weight: 37.000 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Unknown
  • Form: Unassigned
Reactions Reported:
Loose stool Vomiting Decreased appetite Decreased drinking Medication error NOS Lack of efficacy - NOS
Outcomes: Ongoing

Dog, Cattle Dog - Australian (blue heeler, red heeler, Queensland cattledog), Male, 8 year, 14.061 kilogram • Drug: MSK, Tablet, Oral, Dose: 125 Milligram per dose, Frequency: 12 per hour • Reactions: Haematuria, Stranguria, Pollakiuria, Urine abnormalities NOS, Bilirubinuria… • Outcome: Recovered/Normal

  • Report ID: USA-USFDACVM-2025-US-073737
  • Serious AE: No
  • Treated For AE: Yes
  • Sex: Male
  • Age: 8.00 Year
  • Weight: 14.061 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Oral
  • Form: Tablet
  • Dose: 125 Milligram per dose
  • Frequency: 12 per hour
Reactions Reported:
Haematuria Stranguria Pollakiuria Urine abnormalities NOS Bilirubinuria Hypophosphataemia Hypochloraemia
Outcomes: Recovered/Normal

Dog, ['Chihuahua', 'Mixed (Dog)'], Male, 7 year, 2.268 kilogram • Drug: MSK, Oral • Reactions: Obtunded, Hypothermia, Hypotension, Hypoglycaemia, Cardiorespiratory arrest… • Outcome: Euthanized

  • Report ID: USA-USFDACVM-2025-US-073969
  • Serious AE: Yes
  • Treated For AE: Yes
  • Sex: Male
  • Age: 7.00 Year
  • Weight: 2.268 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Oral
Reactions Reported:
Obtunded Hypothermia Hypotension Hypoglycaemia Cardiorespiratory arrest Prolonged one stage prothrombin time Hyperphosphataemia Hypercalcaemia Elevated alanine aminotransferase Elevated aspartate aminotransferase Hypoproteinaemia Hypoalbuminaemia Reduced globulins Decreased cholesterol Thrombocytopenia Haematochezia Regurgitation Death by euthanasia Lateral recumbency Dehydration
Outcomes: Euthanized

Dog, Retriever - Labrador, Female, 11 year, 34.292 kilogram • Drug: MSK, Unassigned, Unknown • Reactions: Tiredness (lethargy), Medication error NOS, Unsteady walking (ataxia), Hyperactivity, Tremors • Outcome: Recovered/Normal

  • Report ID: USA-USFDACVM-2025-US-072879
  • Serious AE: Yes
  • Treated For AE: Yes
  • Sex: Female
  • Age: 11.00 Year
  • Weight: 34.292 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Unknown
  • Form: Unassigned
Reactions Reported:
Tiredness (lethargy) Medication error NOS Unsteady walking (ataxia) Hyperactivity Tremors
Outcomes: Recovered/Normal

Dog, Terrier - Bull, Female, 7 year, 17.6 kilogram • Drug: MSK, Unknown • Reactions: Leucopenia NOS, Anaemia NOS, Hypoalbuminaemia, Neutropenia, Pyoderma… • Outcome: Ongoing

  • Report ID: USA-USFDACVM-2025-US-072729
  • Serious AE: No
  • Treated For AE: Yes
  • Sex: Female
  • Age: 7.00 Year
  • Weight: 17.600 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Unknown
Reactions Reported:
Leucopenia NOS Anaemia NOS Hypoalbuminaemia Neutropenia Pyoderma Reduced globulins Hypophosphataemia Non-regenerative anaemia Low serum alkaline phosphatase Pale mucous membrane Elevated alanine aminotransferase Decreased packed cell volume Tiredness (lethargy) Hypocalcaemia Elevated aspartate aminotransferase Hypoproteinaemia Proteinuria Electrolyte disorder Disorder of red blood cell NOS Elevated creatine-kinase Other coagulation investigation abnormality Increased band neutrophilia Elevated mean corpuscular volume Lymphopenia Other abnormal test result NOS Diarrhea Panleucopenia Eosinopenia Decreased haematocrit Increased percentage reticulocytes
Outcomes: Ongoing

Dog, Corso Dog, Male, 5 year, 63.5 kilogram • Drug: MSK, Unknown • Reactions: Urination, Excessive thirst, Inappropriate urination • Outcome: Outcome Unknown

  • Report ID: USA-USFDACVM-2025-US-072061
  • Serious AE: No
  • Treated For AE: No
  • Sex: Male
  • Age: 5.00 Year
  • Weight: 63.500 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Unknown
Reactions Reported:
Urination Excessive thirst Inappropriate urination
Outcomes: Outcome Unknown

Dog, Terrier - Bull - American Pit, Male, 2 year, 29.03 kilogram • Drug: MSK, Unassigned, Oral • Reactions: Otitis externa, Trigeminus paralysis, Vomiting, Cough, Muscle atrophy… • Outcome: Ongoing

  • Report ID: USA-USFDACVM-2025-US-072504
  • Serious AE: Yes
  • Treated For AE: Yes
  • Sex: Male
  • Age: 2.00 Year
  • Weight: 29.030 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Oral
  • Form: Unassigned
Reactions Reported:
Otitis externa Trigeminus paralysis Vomiting Cough Muscle atrophy Elevated serum alkaline phosphatase Elevated alanine aminotransferase Drooling Unusual stool colour Erythema Elevated gamma-glutamyl transferase Elevated total bilirubin Abnormal ultrasound finding Hepatic fibrosis Hepatitis Tiredness (lethargy) Angioedema Generalised rash Trouble breathing (dyspnea) Increased lung sounds Leucocytosis NOS Icterus Abnormal radiograph finding Jaw disorder
Outcomes: Ongoing

Data source: FDA openFDA Animal & Veterinary adverse event reports.

Overdose Information

No approved overdose-management text is linked yet. If overdose is suspected, contact a veterinarian or emergency clinic immediately.

Storage & Handling

Store at room temperature.

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