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Roxee Medication Guide

Midazolam

Medication reference facts with explicit FDA-approval, off-label, source-limited, and safety context. Roxee does not sell, prescribe, or dispense medications.

Both Source review pending Source coverage pending Owner quick guide first
Start Symptom Intake Talk to a Vet / Find a Vet Near You

Veterinary professional?

Showing simplified owner view. Switch to Vet View for full technical detail.

Data freshness

Reference facts
Source review pending
No refresh timestamp yet

Roxee is still reviewing source support for this medication profile.

FDA applications
Regulatory match pending
No refresh timestamp yet

Roxee has safety or ingredient evidence for this medication, but a regulatory product/application match is still pending.

Safety reports
Safety data refreshed
Aug 6, 2026, 7:49 p.m.

openFDA reaction terms and case summaries are supporting evidence, not proof of causality.

Source timing details
Source timing details
  • Reference facts: Source Roxee | Refreshed Jul 22, 2026, 7:08 PM UTC
    The reference fact projection used for browse cards and quick facts.
  • openFDA reaction terms: Source FDA openFDA | Refreshed Aug 6, 2026, 7:52 PM UTC
  • openFDA case summaries: Source FDA openFDA | Refreshed Aug 6, 2026, 7:52 PM UTC
Illustration placeholder
Midazolam

Midazolam

Drug type: Generic ingredient • Generic profile • Source coverage pending

Both 80% reference complete

Species: Both

Approval status: Source coverage pending. Roxee has limited supporting content for this record, but no on-page official FDA animal-drug document is linked yet. Treat it as source-limited until the ETL backfill adds official coverage.

Medication Snapshot

Merged from the current Roxee medication system with field-level provenance, freshness, and completeness tracking.

Midazolam

Senvelgo (velagliflozin oral solution) is approved in cats for control of hyperglycemia associated with diabetes mellitus. Species commonly shown: Both.

Generic name
Midazolam
Species
Both
Completeness
80%
Validation
Incomplete

Indications / Uses

Senvelgo (velagliflozin oral solution) is approved in cats for control of hyperglycemia associated with diabetes mellitus.

Side Effects

Top reported reactions (openFDA): Vomiting, Seizure NOS, Death, Lethargy (see also Central nervous system depression in Neurological), Diarrhoea, Death by euthanasia.

FAQ

Both

Source Transparency

Add to My Pet's Medications

Choose a pet, confirm current or past, and optionally add reminder notes.

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Pet Owner Quick Guide

Start here first for the safest next-step summary before the deeper medication detail.

Roxee still has limited plain-language guidance for this medication. Use the official documents and your veterinarian's instructions for product-specific details.

Used for:

Your vet decides this. Here's what owners typically ask/watch for.

Dosing note:

Exact dosing depends on your pet's species, weight, and health status. Use your veterinarian's instructions for the exact dose and schedule.

What to watch for:

  • wobbly/unsteady walking (1 reports)
  • Loss of appetite (1 reports)

When to call the vet:

  • Repeated vomiting or diarrhea.
  • Severe lethargy (hard to wake, very low energy).
  • Collapse or fainting.
  • Trouble breathing.
  • Facial swelling or hives.
  • Blood in vomit or stool.

Bloodwork changes are grouped in Vet View.

What to tell or ask your vet today:

  • Is this medicine the right fit for my pet’s current symptoms?
  • Which warning signs mean I should call back right away?
  • How should I handle missed doses or refusal to take the medicine?

Next actions

Talk to a Vet / Find a Vet Near You Save to pet meds Share page Review report evidence
Research brief

Medication Research Insights

A source-aware map of what to know, what is uncertain, and what to verify with your veterinarian.

Source Backed Signals

What to know

Evidence-backed context Limited

Roxee has limited cited overview evidence for Midazolam; use the official documents and your veterinarian's instructions for product-specific decisions.

Source: openFDA case USA-USFDACVM-2025-US-070810
Safety signal coverage Reported signals

32 tracked reaction signals; 32 reported cases; 28 serious reports; 2 species groups. These are reporting and label-derived signals for interpretation with a veterinarian.

Source: openFDA case USA-USFDACVM-2025-US-070810
Interpretation guardrail Not causation

Adverse-event reports help form a watch list, but they do not prove the medication caused the reaction and they are not a risk ranking between medications.

Evidence tension

Stronger signal Label / review

Official labels, package inserts, and reviewed summaries carry more weight than isolated reports.

Source: openFDA case USA-USFDACVM-2025-US-070810
Weaker signal Reported data

Case reports and openFDA terms are useful for pattern awareness, but they are incomplete, can include multiple exposures, and do not estimate an individual pet's probability of harm.

Reaction signal map

Most reported reactions Top terms

Unsteady walking (ataxia) (1 reports), Loss of appetite (1 reports), Decreased blood urea nitrogen (BUN) or creatinine (1 reports), Decreased appetite (1 reports), Death (1 reports)

Body systems represented Signal grouping

Digestive (3), Skin & allergy (2), Neurologic (1), Behavior (2)

Explore supporting adverse reports

Species and breed lens

Species represented in reports Species lens

Cat (18 reports), Dog (14 reports)

Breed metadata in reports Metadata only

Spaniel - King Charles Cavalier (1), Retriever - Labrador (1), Maine Coon (1), Chihuahua (1). These are report metadata, not proof that a breed is at higher risk.

What your vet may verify

Fit for this patient Vet check

Verify whether Midazolam fits the pet's species, current diagnosis, age, weight, organ status, pregnancy/lactation status, and concurrent medications.

Evidence limitations Evidence review

Separate label-backed warnings from adverse-event reports and owner observations before changing the plan.

What to watch next

Watch list Owner-safe

wobbly/unsteady walking, Loss of appetite

Call sooner if Escalation

Repeated vomiting or diarrhea. Severe lethargy (hard to wake, very low energy). Collapse or fainting.

Bottom line: Use this Midazolam brief as a structured watch list and source map, not as a reason to start, stop, or change treatment without your veterinarian.
Vet source depth
  1. openFDA case USA-USFDACVM-2025-US-070810 · adverse_reaction · adverse reactions

Evidence

Review status / Updated / Sources

Review status: Clinical reviewer not listed

Updated: April 15, 2026, 10:04 AM UTC

Sources:
Safety & side effects

Side effects to monitor:

  • wobbly/unsteady walking
  • Loss of appetite

Most reported reactions:

  • Unsteady walking (ataxia) (1 reports)
  • Loss of appetite (1 reports)
  • Decreased blood urea nitrogen (BUN) or creatinine (1 reports)
Explore reported case details

Emergency warning signs:

  • Repeated vomiting or diarrhea.
  • Severe lethargy (hard to wake, very low energy).
  • Collapse or fainting.
  • Trouble breathing.
Talk to a Vet / Find a Vet Near You Start Symptom Intake

Vet Fast Scan

Source-backed clinical checkpoints for quick review.

FDA-labeled species
Not linked yet
Indication / use
Your vet decides this. Here's what owners typically ask/watch for.
Form / route / dose
Confirm product label and patient-specific plan.
Warnings
No structured warnings linked yet.
Adverse-event caveat
openFDA adverse-event cases are reported signals. They are not verified, do not prove causation, and do not estimate a pet's individual risk.
Source docs
No source documents linked yet.

Quick Facts

Official label facts first, then secondary summaries. Marketing content is separated below.

Species: Both
Manufacturer: Manufacturer not confirmed

Adverse Reactions

Snapshot first, detailed rows second. This section summarizes signal data and is not a diagnosis.

Reported case explorer

Filter stored openFDA reports by pet and report attributes. Counts describe reports in this data set, not risk.

Clear filters
openFDA adverse-event cases are reported signals. They are not verified, do not prove causation, and do not estimate a pet's individual risk.
Stored reports
38
Matching reports
38
Active filters
0
Reset
Drill into common report signals
Death (11) Seizure NOS (8) Lethargy (see also Central nervous system depression in Neurological) (7) Behavioural disorder NOS (5) Other (35) Neurologic (15) Skin & allergy (9) Digestive (6)
Showing up to 50 matching reports.

USA-USFDACVM-2026-US-014468

Received 2026-03-26 · MSK · MSK

Serious
Species
Dog
Breed
Spaniel - King Charles Cavalier
Size / weight
10-24 lb (9.48 Kilogram)
Age
4-7 years (7 Year)
Sex
Female Unknown
Region
USA
Reactions
CyanosisRespiratory arrestPremature ventricular contractionsDeath
Body systems
Other
Outcomes
Died

USA-USFDACVM-2026-US-012958

Received 2026-03-18 · MSK · MSK

Serious
Species
Dog
Breed
Retriever - Labrador
Size / weight
50-99 lb (29.211 Kilogram)
Age
4-7 years (7 Year)
Sex
Female Unknown
Region
USA
Reactions
AtaxiaHind limb paresisProprioception deficitPain NOSPartial lack of efficacy
Body systems
NeurologicOtherEffectiveness
Outcomes
Ongoing

USA-USFDACVM-2026-US-012648

Received 2026-03-16 · MSK · MSK

Serious
Species
Cat
Breed
Maine Coon
Size / weight
10-24 lb (8.591 Kilogram)
Age
1-3 years (3 Year)
Sex
Male Neutered
Region
USA
Reactions
OpisthotonusHorizontal nystagmusProlonged anaesthesiaIntentional misuse
Body systems
Other
Outcomes
Recovered/Normal

USA-USFDACVM-2026-US-012640

Received 2026-03-16 · MSK · MSK

Serious
Species
Dog
Breed
Chihuahua
Size / weight
Under 10 lb (2.54 Kilogram)
Age
8+ years (8.25 Year)
Sex
Female Unknown
Region
USA
Reactions
Muscle tremorOpisthotonusRigidity of limbsStar-gazingProlonged anaesthesiaIntentional misuse
Body systems
NeurologicOther
Outcomes
Recovered/Normal

USA-USFDACVM-2026-US-014081

Received 2026-03-13 · MSK · MSK

Serious
Species
Dog
Breed
Cattle Dog - Australian (blue heeler, red heeler, Queensland cattledog)
Size / weight
50-99 lb (23.2 Kilogram)
Age
4-7 years (5 Year)
Sex
Male Neutered
Region
USA
Reactions
Sudden death
Body systems
Other
Outcomes
Died

USA-USFDACVM-2026-US-012855

Received 2026-03-13 · MSK · MSK

Serious
Species
Dog
Breed
Pug
Sex
Unknown
Region
USA
Reactions
DeathCardiac arrest
Body systems
Other
Outcomes
Died

USA-USFDACVM-2026-US-012843

Received 2026-03-13 · MSK · MSK

Serious
Species
Dog
Breed
Bulldog - French
Sex
Unknown
Region
USA
Reactions
DeathCardiac arrest
Body systems
Other
Outcomes
Died

USA-USFDACVM-2026-US-012217

Received 2026-03-13 · MSK · MSK

Non-serious
Species
Cat
Breed
Domestic Longhair
Size / weight
Under 10 lb (1.992 Kilogram)
Age
Under 1 year (5 Month)
Sex
Female Intact
Region
USA
Reactions
Elevated temperatureDecreased body temperature
Body systems
Other
Outcomes
Ongoing

USA-USFDACVM-2026-US-014171

Received 2026-03-12 · MSK · MSK

Serious
Species
Cat
Breed
Domestic Shorthair
Size / weight
10-24 lb (5.715 Kilogram)
Age
4-7 years (5 Year)
Sex
Male Neutered
Region
USA
Reactions
Behavioural disorder NOSGait abnormalityHyperthermiaMonoparesis (paralysis of limb)
Body systems
BehaviorOther
Outcomes
Outcome Unknown

USA-USFDACVM-2026-US-009874

Received 2026-03-05 · MSK · MSK

Serious
Species
Cat
Breed
Domestic Shorthair
Size / weight
Under 10 lb (2.522 Kilogram)
Age
8+ years (13 Year)
Sex
Female Unknown
Region
USA
Reactions
DeathIntentional misuse
Body systems
Other
Outcomes
Died

USA-USFDACVM-2026-US-009771

Received 2026-03-02 · MSK · MSK

Serious
Species
Cat
Breed
Domestic Shorthair
Size / weight
10-24 lb (5.44 Kilogram)
Age
4-7 years (4 Year)
Sex
Female Neutered
Region
USA
Reactions
Lethargy (see also Central nervous system depression in Neurological)AnorexiaAnuriaAdipsiaSeizure NOSDeathConstipationStaringHead twitching
Body systems
NeurologicDigestiveOtherSkin & allergy
Outcomes
Died

USA-USFDACVM-2026-US-009570

Received 2026-02-26 · MSK · MSK

Serious
Species
Cat
Breed
Domestic Shorthair
Size / weight
10-24 lb (7.87 Kilogram)
Age
8+ years (11.8 Year)
Sex
Male Neutered
Region
USA
Reactions
FeverNot urinatingElevated aspartate aminotransferase (AST)Decreased blood urea nitrogen (BUN) or creatinineLow creatinineHypocalcaemiaHypoproteinaemia
Body systems
Other
Outcomes
Recovered/Normal

USA-USFDACVM-2026-US-009224

Received 2026-02-23 · MSK · MSK

Serious
Species
Cat
Breed
Domestic Shorthair
Size / weight
10-24 lb (5.443 Kilogram)
Age
8+ years (14 Year)
Sex
Male Neutered
Region
USA
Reactions
Seizure NOSAtaxia
Body systems
Neurologic
Outcomes
Ongoing

USA-USFDACVM-2026-US-007434

Received 2026-02-18 · MSK · MSK

Non-serious
Species
Cat
Breed
Domestic Shorthair
Size / weight
10-24 lb (5.44 Kilogram)
Age
1-3 years (3 Year)
Sex
Male Neutered
Region
USA
Reactions
Application site alopecia
Body systems
Skin & allergy
Outcomes
Outcome Unknown

USA-USFDACVM-2026-US-008820

Received 2026-02-16 · MSK · MSK

Serious
Species
Cat
Breed
Siamese
Size / weight
10-24 lb (4.763 Kilogram)
Age
1-3 years (1 Year)
Sex
Male Neutered
Region
USA
Reactions
AnaphylaxisVomitingBloody stoolLethargy (see also Central nervous system depression in Neurological)HypothermiaElevated alanine aminotransferase (ALT)Elevated blood urea nitrogen (BUN)HyperphosphataemiaLeukocytosis NOSElevated total bilirubin
Body systems
OtherDigestiveNeurologic
Outcomes
Ongoing

USA-USFDACVM-2026-US-006824

Received 2026-02-16 · MSK · MSK

Non-serious
Species
Cat
Breed
Domestic Shorthair
Size / weight
Under 10 lb (3.63 Kilogram)
Age
Under 1 year (6 Month)
Sex
Male Intact
Region
USA
Reactions
HyperactivityNot sleeping
Body systems
Other
Outcomes
Recovered/Normal

USA-USFDACVM-2026-US-009550

Received 2026-02-08 · MSK · MSK

Serious
Species
Cat
Breed
Domestic Shorthair
Size / weight
10-24 lb (6.894 Kilogram)
Age
4-7 years (6.42 Year)
Sex
Male Neutered
Region
USA
Reactions
Open mouth breathingRespiratory distressFeverNot eating
Body systems
Other
Outcomes
Recovered/Normal

USA-USFDACVM-2026-US-005986

Received 2026-02-04 · MSK · MSK

Serious
Species
Dog
Breed
Terrier - Boston
Size / weight
25-49 lb (12.3 Kilogram)
Age
1-3 years (3.6 Year)
Sex
Female Neutered
Region
USA
Reactions
Hives (see also Skin)AngioedemaFacial swelling (see also Skin)
Body systems
Skin & allergyOther
Outcomes
Recovered/Normal

USA-USFDACVM-2026-US-008917

Received 2026-01-29 · MSK · MSK

Serious
Species
Cat
Breed
Domestic Shorthair
Size / weight
10-24 lb (6.53 Kilogram)
Age
1-3 years (1.33 Year)
Sex
Male Neutered
Region
USA
Reactions
PtyalismTremorSeizure NOSAggressionLeukocytosis NOSNeutrophiliaEosinopeniaHypernatraemiaElevated cholesterol (total)Eyes rolling backHyperactivityElevated haematocritDisorientationUrinary tract obstruction/blockageAnaemia NOSOther abnormal test result NOSMydriasisActing tenseMental confusionTwitchingBradycardiaDecreased heart rateBehavioural disorder NOSHaematuriaProteinuria
Body systems
OtherNeurologicBehaviorSkin & allergy
Outcomes
Outcome Unknown

USA-USFDACVM-2026-US-002976

Received 2026-01-20 · MSK · MSK

Serious
Species
Dog
Breed
Shih Tzu
Size / weight
Under 10 lb (2.449 Kilogram)
Age
Under 1 year (2 Month)
Sex
Male Intact
Region
USA
Reactions
Lethargy (see also Central nervous system depression in Neurological)VomitingBloody diarrhoeaDiarrhoeaReluctant to moveDecreased body temperaturePale mucous membraneHypoglycaemiaFluid in abdomen NOSFeverDistension of abdomenNeutropeniaLeukocytosis NOSDecreased haematocritNot eatingObtundedHypersalivationAbdominal discomfortDecreased skin turgorBreathing difficultyFlaccid musclesProlonged capillary refill timeRegurgitationLack of efficacy - NOSLymphopeniaMonocytosisLeukopenia NOSHyponatremiaHypercalcaemiaIncreased band neutrophiliaIleusAbnormal radiograph findingIntestinal thickeningHypokalaemiaNasal dischargeIncreased respiratory rateLymphocytosisAbnormal ultrasound findingLateral recumbencyWeak pulseIntentional misuse
Body systems
NeurologicDigestiveOtherEffectiveness
Outcomes
Ongoing

USA-USFDACVM-2026-US-003253

Received 2026-01-16 · MSK · MSK

Serious
Species
Cat
Breed
Domestic Shorthair
Size / weight
10-24 lb (6.53 Kilogram)
Age
1-3 years (1.33 Year)
Sex
Male Neutered
Region
USA
Reactions
PtyalismTremorSeizure NOSAggressionLeukocytosis NOSNeutrophiliaEosinopeniaHypernatraemiaElevated cholesterol (total)Eyes rolling backHyperactivityElevated haematocritDisorientationUrinary tract obstruction/blockageAnaemia NOSOther abnormal test result NOSMydriasisActing tenseMental confusionTwitchingBradycardiaDecreased heart rateBehavioural disorder NOSHaematuriaProteinuria
Body systems
OtherNeurologicBehaviorSkin & allergy
Outcomes
Outcome Unknown

USA-USFDACVM-2025-US-075214

Received 2025-12-24 · MSK · MSK

Serious
Species
Dog
Breed
Siberian Husky
Size / weight
25-49 lb (21.682 Kilogram)
Age
8+ years (9 Year)
Sex
Male Neutered
Region
USA
Reactions
Injection site lesionCrustInjection site ulcerInjection site erythemaInjection site discharge NOS
Body systems
Other
Outcomes
Ongoing

USA-USFDACVM-2025-US-074194

Received 2025-12-19 · MSK · MSK

Serious
Species
Dog
Breed
Bulldog - French
Size / weight
25-49 lb (12.428 Kilogram)
Age
8+ years (8 Year)
Sex
Male Neutered
Region
USA
Reactions
Decreased appetiteDecreased drinkingLethargy (see also Central nervous system depression in Neurological)PantingTense musclesSeizure NOSInappropriate defecationInappropriate urinationUnable to walkProprioception deficitGeneralised weaknessLamenessLimb non-weight bearingAbnormal radiograph findingMedication error NOS
Body systems
DigestiveOtherNeurologic
Outcomes
Recovered/Normal

USA-USFDACVM-2025-US-074994

Received 2025-12-17 · MSK · MSK

Serious
Species
Cat
Breed
Maine Coon
Size / weight
10-24 lb (6.58 Kilogram)
Age
8+ years (13 Year)
Sex
Male Neutered
Region
USA
Reactions
TwitchingFocal seizureDeathLethargy (see also Central nervous system depression in Neurological)
Body systems
Skin & allergyNeurologicOther
Outcomes
Died

USA-USFDACVM-2025-US-074366

Received 2025-12-17 · MSK · MSK

Non-serious
Species
Dog
Breed
Coton de Tuléar
Size / weight
Under 10 lb (3.719 Kilogram)
Age
4-7 years (4 Year)
Sex
Female Unknown
Region
USA
Reactions
Lack of efficacy - NOSVomitingIntentional misuse
Body systems
EffectivenessDigestiveOther
Outcomes
Ongoing

USA-USFDACVM-2025-US-074168

Received 2025-12-17 · MSK · MSK

Non-serious
Species
Cat
Breed
Domestic Mediumhair
Size / weight
10-24 lb (5.27 Kilogram)
Age
8+ years (8.5 Year)
Sex
Male Neutered
Region
USA
Reactions
DysphoriaSleep disturbance NOSHallucinationThird eyelid prolapseDilated pupilsClosed eyelid
Body systems
Other
Outcomes
Recovered/Normal

USA-USFDACVM-2025-US-073864

Received 2025-12-17 · MSK · MSK

Serious
Species
Cat
Breed
Domestic Shorthair
Size / weight
Under 10 lb (4.3 Kilogram)
Age
1-3 years (3 Year)
Sex
Male Neutered
Region
USA
Reactions
Lethargy (see also Central nervous system depression in Neurological)DullBehavioural disorder NOSShallow breathingDeath
Body systems
NeurologicOtherBehavior
Outcomes
Died

USA-USFDACVM-2025-US-073492

Received 2025-12-16 · MSK · MSK

Non-serious
Species
Cat
Breed
Domestic Shorthair
Size / weight
10-24 lb (5.44 Kilogram)
Age
8+ years (12 Year)
Sex
Male Neutered
Region
USA
Reactions
Application site hair lossHair loss NOS
Body systems
Skin & allergy
Outcomes
Outcome Unknown

USA-USFDACVM-2025-US-073109

Received 2025-12-11 · MSK · MSK

Serious
Species
Dog
Breed
Bulldog - French
Size / weight
25-49 lb (12.927 Kilogram)
Age
8+ years (8 Year)
Sex
Female Unknown
Region
USA
Reactions
TachycardiaApnoeaCyanosisCardiac arrestDeathAngioedema
Body systems
Other
Outcomes
Died

USA-USFDACVM-2025-US-072789

Received 2025-12-11 · MSK · MSK

Serious
Species
Dog
Breed
Dachshund (unspecified)
Size / weight
10-24 lb (4.536 Kilogram)
Age
8+ years (12 Year)
Sex
Female Unknown
Region
USA
Reactions
Apnoea
Body systems
Other
Outcomes
Ongoing

USA-USFDACVM-2025-US-073513

Received 2025-12-09 · MSK · MSK

Non-serious
Species
Dog
Breed
['Pointing Dog - Hungarian Short-haired (Vizsla)', 'Retriever - Labrador']
Size / weight
50-99 lb (40.415 Kilogram)
Age
8+ years (8 Year)
Sex
Male Neutered
Region
USA
Reactions
Application site scarInjection site alopeciaInjection site reaction NOSInjection site noduleMast cell tumourLack of efficacy (neoplasia, relapse)
Body systems
OtherSkin & allergyEffectiveness
Outcomes
Outcome Unknown

USA-USFDACVM-2025-US-072925

Received 2025-12-05 · MSK · MSK

Serious
Species
Dog
Breed
['Bulldog - American', 'Dog (unknown)']
Size / weight
50-99 lb (27.941 Kilogram)
Age
8+ years (9 Year)
Sex
Male Intact
Region
USA
Reactions
UnwellRecumbencyReduced responsesSeizure NOSStrokeDeathOverdose
Body systems
OtherNeurologic
Outcomes
Died

USA-USFDACVM-2025-US-072415

Received 2025-12-04 · MSK · MSK

Non-serious
Species
Cat
Breed
Domestic (unspecified)
Size / weight
Under 10 lb (3.86 Kilogram)
Age
1-3 years (2 Year)
Sex
Female Intact
Region
USA
Reactions
DysphoriaElevated temperature
Body systems
Other
Outcomes
Ongoing

USA-USFDACVM-2025-US-072468

Received 2025-12-01 · MSK · MSK

Serious
Species
Dog
Breed
['Shih Tzu', 'Spitz - German Pomeranian']
Size / weight
Under 10 lb (3.4 Kilogram)
Age
8+ years (8 Year)
Sex
Female Neutered
Region
USA
Reactions
Seizure NOSDeath
Body systems
NeurologicOther
Outcomes
Died

USA-USFDACVM-2025-US-070810

Received 2025-12-01 · MSK · MSK

Serious
Species
Dog
Breed
['Shih Tzu', 'Spitz - German Pomeranian']
Size / weight
Under 10 lb (3.402 Kilogram)
Age
8+ years (8 Year)
Sex
Female Neutered
Region
USA
Reactions
Seizure NOSDeathMedication error NOSNot eatingLeucocytosis NOSPain NOSElevated lactateHyperglycaemiaAbdominal discomfortAbnormal radiograph findingNeutrophiliaMonocytosisElevated triglyceride
Body systems
NeurologicOther
Outcomes
Died

USA-USFDACVM-2025-US-072217

Received 2025-11-26 · MSK · MSK

Serious
Species
Dog
Breed
Pug
Size / weight
10-24 lb (9.979 Kilogram)
Age
4-7 years (7 Year)
Sex
Male Intact
Region
USA
Reactions
Deafness
Body systems
Other
Outcomes
Outcome Unknown

USA-USFDACVM-2025-US-071209

Received 2025-11-25 · MSK · MSK

Serious
Species
Dog
Breed
Portuguese Water Dog
Size / weight
50-99 lb (23.406 Kilogram)
Age
4-7 years (6 Year)
Sex
Female Neutered
Region
USA
Reactions
AnorexiaInjection site itchingSwelling NOSLethargy (see also Central nervous system depression in Neurological)Injection site mucopurulent dischargeInjection site swellingInjection site skin discolourationInjection site bruisingInjection site abscessInjection site necrosisSicknessInjection site skin change NOSOther abnormal test result NOS
Body systems
DigestiveSkin & allergyNeurologicOther
Outcomes
Ongoing

USA-USFDACVM-2025-US-065881

Received 2025-11-05 · MSK · MSK

Serious
Species
Cat
Breed
Domestic Shorthair
Size / weight
10-24 lb (6.6 Kilogram)
Age
8+ years (15 Year)
Sex
Male Neutered
Region
USA
Reactions
RestlessnessBladder distensionBehavioural disorder NOSUrinary tract obstruction/blockageUrinary bladder disorder NOSStaring
Body systems
OtherBehavior
Outcomes
Outcome Unknown

Tap or hover a reaction to see what it means in plain language.

Tracked signals
32
Reported cases
32
Serious reports
28
Species represented
2
Grouped by Body System
Digestive (3) · Loss of appetite, Decreased appetite, Bloody diarrhoea Skin & allergy (2) · Hair loss at application site, Application site hair loss Neurologic (1) · Unsteady walking (ataxia) Behavior (2) · Behavioral disorder (unspecified), Aggression Other (24) · Decreased blood urea nitrogen (BUN) or creatinine, Death, Deafness
Most Reported Reactions
Reaction Body system Cases Species Serious cases
Neurologic 1 Cat 1
Digestive 1 Cat 1
Other 1 Cat 1
Digestive 1 Dog 1
Other 1 Cat 1
Other 1 Dog 1
Other 1 Dog 1
Other 1 Dog 1

Species coverage: Cat (18) Dog (14)

View detailed reaction table
Reaction Body system Species Seriousness Frequency Reports
Neurologic Cat Serious - 1
Digestive Cat Serious - 1
Skin & allergy Cat Non-serious - 1
Other Cat Serious - 1
Digestive Dog Serious - 1
Other Cat Serious - 1
Other Dog Serious - 1
Other Dog Serious - 1
Other Dog Serious - 1
Other Cat Serious - 1
Other Cat Non-serious - 1
Other Dog Serious - 1
Other Dog Serious - 1
Other Cat Serious - 1
Other Cat Serious - 1
Digestive Dog Serious - 1
Other Cat Serious - 1
Behavior Cat Serious - 1
Other Dog Non-serious - 1
Skin & allergy Cat Non-serious - 1
Other Dog Serious - 1
Other Cat Serious - 1
Other Dog Serious - 1
Other Cat Serious - 1
Other Cat Serious - 1
Behavior Cat Serious - 1
Other Cat Serious - 1
Other Cat Serious - 1
Other Dog Serious - 1
Other Dog Serious - 1
Other Dog Serious - 1
Other Dog Serious - 1
Source metadata:
Veterinary reference (advanced)

Canonical medication sections are above. This legacy block remains available for deeper cross-reference without cluttering the primary workflow.

At a Glance

Quick facts and links to official labeling and safety signals.

Data freshness
  • Reference facts: Source Roxee | Refreshed Jul 22, 2026, 7:08 PM UTC
    The reference fact projection used for browse cards and quick facts.
  • openFDA reaction terms: Source FDA openFDA | Refreshed Aug 6, 2026, 7:52 PM UTC
  • openFDA case summaries: Source FDA openFDA | Refreshed Aug 6, 2026, 7:52 PM UTC
Official (FDA)
Identity: Generic ingredient • No FDA branded products linked
No official FDA brand rows linked yet for this ingredient.
Case-reported brands (openFDA): MSK
Catalog species: Both
Safety (openFDA)
Top reactions: Dog 108 • Cat 77 • View
Case summaries: 38 (showing 8) • View
openFDA reports are unverified and do not prove causation.
Diagnosis Codes

Diagnosis-code mappings are not available for this medication yet.

Counseling and Monitoring Highlights

Global Pet owner/Vet mode is controlled in the header. This section avoids duplicate in-page persona tabs.

Top reaction signals
Unsteady walking (ataxia) (1) Loss of appetite (1) Decreased blood urea nitrogen (BUN) or creatinine (1) Decreased appetite (1) Death (1) Deafness (1) Cyanosis (1) Crust (1)

Data Sources & Change Log

Every non-trivial field is expected to include provenance and update timestamps.

Official 96 Clinical 7 Manufacturer 0 Marketing 0
Current Field Facts
  • monitoring: Monitor blood glucose and ketones, hydration status, appetite, and clinical response at regular intervals. (Clinical, 2026-04-21)
  • monitoring: Monitor blood glucose and ketones, hydration status, appetite, and clinical response at regular intervals. (Clinical, 2026-04-20)
  • monitoring: Monitor blood glucose and ketones, hydration status, appetite, and clinical response at regular intervals. (Clinical, 2026-04-19)
  • monitoring: Monitor blood glucose and ketones, hydration status, appetite, and clinical response at regular intervals. (Clinical, 2026-04-17)
  • monitoring: Monitor blood glucose and ketones, hydration status, appetite, and clinical response at regular intervals. (Clinical, 2026-04-16)
  • monitoring: Monitor blood glucose and ketones, hydration status, appetite, and clinical response at regular intervals. (Clinical, 2026-04-16)
  • side_effects: Top reported reactions (openFDA): Vomiting, Seizure NOS, Death, Lethargy (see also Central nervous system depression in Neurological), Diarrhoea, Death by euth… (Clinical, 2026-04-11)
  • side_effects: Top reported reactions (openFDA): Vomiting, Seizure NOS, Death, Lethargy (see also Central nervous system depression in Neurological), Diarrhoea, Death by euth… (Official, 2026-07-22)
  • side_effects: Top reported reactions (openFDA): Vomiting, Seizure NOS, Death, Lethargy (see also Central nervous system depression in Neurological), Diarrhoea, Death by euth… (Official, 2026-07-22)
  • side_effects: Top reported reactions (openFDA): Vomiting, Seizure NOS, Death, Lethargy (see also Central nervous system depression in Neurological), Diarrhoea, Death by euth… (Official, 2026-07-22)
  • side_effects: Top reported reactions (openFDA): Vomiting, Seizure NOS, Death, Lethargy (see also Central nervous system depression in Neurological), Diarrhoea, Death by euth… (Official, 2026-07-20)
  • side_effects: Top reported reactions (openFDA): Vomiting, Seizure NOS, Death, Lethargy (see also Central nervous system depression in Neurological), Diarrhoea, Death by euth… (Official, 2026-07-19)
  • side_effects: Top reported reactions (openFDA): Vomiting, Seizure NOS, Death, Lethargy (see also Central nervous system depression in Neurological), Diarrhoea, Death by euth… (Official, 2026-07-16)
  • side_effects: Top reported reactions (openFDA): Vomiting, Seizure NOS, Death, Lethargy (see also Central nervous system depression in Neurological), Diarrhoea, Death by euth… (Official, 2026-07-16)
  • side_effects: Top reported reactions (openFDA): Vomiting, Seizure NOS, Death, Lethargy (see also Central nervous system depression in Neurological), Diarrhoea, Death by euth… (Official, 2026-07-13)
  • side_effects: Top reported reactions (openFDA): Vomiting, Seizure NOS, Death, Lethargy (see also Central nervous system depression in Neurological), Diarrhoea, Death by euth… (Official, 2026-07-12)
  • side_effects: Top reported reactions (openFDA): Vomiting, Seizure NOS, Death, Lethargy (see also Central nervous system depression in Neurological), Diarrhoea, Death by euth… (Official, 2026-07-11)
  • side_effects: Top reported reactions (openFDA): Vomiting, Seizure NOS, Death, Lethargy (see also Central nervous system depression in Neurological), Diarrhoea, Death by euth… (Official, 2026-07-11)
  • side_effects: Top reported reactions (openFDA): Vomiting, Seizure NOS, Death, Lethargy (see also Central nervous system depression in Neurological), Diarrhoea, Death by euth… (Official, 2026-07-11)
  • side_effects: Top reported reactions (openFDA): Vomiting, Seizure NOS, Death, Lethargy (see also Central nervous system depression in Neurological), Diarrhoea, Death by euth… (Official, 2026-07-10)
Recent Revisions
  • side_effects updated 2026-07-22 19:08 by etl_backfill • Backfilled from existing medication fields
  • side_effects updated 2026-07-22 18:40 by etl_backfill • Backfilled from existing medication fields
  • side_effects updated 2026-07-22 08:29 by etl_backfill • Backfilled from existing medication fields
  • side_effects updated 2026-07-20 10:05 by etl_backfill • Backfilled from existing medication fields
  • side_effects updated 2026-07-19 13:48 by etl_backfill • Backfilled from existing medication fields
  • side_effects updated 2026-07-16 16:34 by etl_backfill • Backfilled from existing medication fields
  • side_effects updated 2026-07-16 15:43 by etl_backfill • Backfilled from existing medication fields
  • side_effects updated 2026-07-13 10:06 by etl_backfill • Backfilled from existing medication fields
  • side_effects updated 2026-07-12 17:56 by etl_backfill • Backfilled from existing medication fields
  • side_effects updated 2026-07-11 19:04 by etl_backfill • Backfilled from existing medication fields
  • side_effects updated 2026-07-11 08:49 by etl_backfill • Backfilled from existing medication fields
  • side_effects updated 2026-07-11 08:05 by etl_backfill • Backfilled from existing medication fields
  • side_effects updated 2026-07-10 21:24 by etl_backfill • Backfilled from existing medication fields
  • side_effects updated 2026-07-07 10:06 by etl_backfill • Backfilled from existing medication fields
  • side_effects updated 2026-07-06 20:16 by etl_backfill • Backfilled from existing medication fields
  • side_effects updated 2026-07-06 08:13 by etl_backfill • Backfilled from existing medication fields
  • side_effects updated 2026-07-03 20:16 by etl_backfill • Backfilled from existing medication fields
  • side_effects updated 2026-07-03 11:05 by etl_backfill • Backfilled from existing medication fields
  • side_effects updated 2026-07-02 22:45 by etl_backfill • Backfilled from existing medication fields
  • side_effects updated 2026-07-01 23:29 by etl_backfill • Backfilled from existing medication fields

Top Reported Reactions (openFDA)

De-duplicated reaction terms grouped by body system from FDA openFDA reports (not verified; does not prove causation).

Digestive
Loss of appetite (1) • Cat Decreased appetite (1) • Dog Bloody diarrhoea (1) • Dog

Showing top 5 for Digestive.

Skin & allergy
Hair loss at application site (1) • Cat Application site hair loss (1) • Cat

Showing top 5 for Skin & allergy.

Neurologic
Unsteady walking (1) • Cat

Showing top 5 for Neurologic.

Behavior
Behavioral disorder (1) • Cat Aggression (1) • Cat

Showing top 5 for Behavior.

Other
Decreased blood urea nitrogen (BUN) or creatinine (1) • Cat Death (1) • Cat Deafness (1) • Dog Cyanosis (1) • Dog Crust (1) • Dog
Show more (19)
Constipation (1) • Cat Closed eyelid (1) • Cat Cardiac arrest (1) • Dog Breathing difficulty (1) • Dog Bradycardia (1) • Cat Bloody stool (1) • Cat Bladder distension (1) • Cat Application site scar (1) • Dog Apnoea (1) • Dog Anuria (1) • Cat Angioedema (1) • Dog Anaphylaxis (1) • Cat Anaemia NOS (1) • Cat Adipsia (1) • Cat Acting tense (1) • Cat Abnormal ultrasound finding (1) • Dog Abnormal radiograph finding (1) • Dog Abnormal cytology (1) • Dog Abdominal discomfort (1) • Dog

Showing top 5 for Other.

Data source: FDA openFDA Animal & Veterinary adverse event reports.

Adverse Event Case Summaries (openFDA)

These are individual FDA adverse event reports. They are unverified and do not prove the medication caused the reaction.

Dog, Spaniel - King Charles Cavalier, Female, 7 year, 9.48 kilogram • Drug: MSK, Injection, solution, Unknown • Reactions: Cyanosis, Respiratory arrest, Premature ventricular contractions, Death • Outcome: Died

  • Report ID: USA-USFDACVM-2026-US-014468
  • Serious AE: Yes
  • Treated For AE: Yes
  • Sex: Female
  • Age: 7.00 Year
  • Weight: 9.480 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Unknown
  • Form: Injection, solution
Reactions Reported:
Cyanosis Respiratory arrest Premature ventricular contractions Death
Outcomes: Died

Dog, Retriever - Labrador, Female, 7 year, 29.211 kilogram • Drug: MSK, Unassigned, Unknown • Reactions: Unsteady walking (ataxia), Hind limb paresis, Proprioception deficit, Pain NOS, Partial lack of efficacy • Outcome: Ongoing

  • Report ID: USA-USFDACVM-2026-US-012958
  • Serious AE: Yes
  • Treated For AE: Yes
  • Sex: Female
  • Age: 7.00 Year
  • Weight: 29.211 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Unknown
  • Form: Unassigned
Reactions Reported:
Unsteady walking (ataxia) Hind limb paresis Proprioception deficit Pain NOS Partial lack of efficacy
Outcomes: Ongoing

Cat, Maine Coon, Male, 3 year, 8.591 kilogram • Drug: MSK, Unassigned, Intramuscular • Reactions: Opisthotonus, Horizontal nystagmus, Prolonged anaesthesia, Intentional misuse • Outcome: Recovered/Normal

  • Report ID: USA-USFDACVM-2026-US-012648
  • Serious AE: Yes
  • Treated For AE: Yes
  • Sex: Male
  • Age: 3.00 Year
  • Weight: 8.591 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Intramuscular
  • Form: Unassigned
Reactions Reported:
Opisthotonus Horizontal nystagmus Prolonged anaesthesia Intentional misuse
Outcomes: Recovered/Normal

Dog, Chihuahua, Female, 8.25 year, 2.54 kilogram • Drug: MSK, Unassigned, Intramuscular • Reactions: Muscle tremor, Opisthotonus, Rigidity of limbs, Star-gazing, Prolonged anaesthesia… • Outcome: Recovered/Normal

  • Report ID: USA-USFDACVM-2026-US-012640
  • Serious AE: Yes
  • Treated For AE: Yes
  • Sex: Female
  • Age: 8.25 Year
  • Weight: 2.540 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Intramuscular
  • Form: Unassigned
Reactions Reported:
Muscle tremor Opisthotonus Rigidity of limbs Star-gazing Prolonged anaesthesia Intentional misuse
Outcomes: Recovered/Normal

Dog, Cattle Dog - Australian (blue heeler, red heeler, Queensland cattledog), Male, 5 year, 23.2 kilogram • Drug: MSK, Injection, Unknown, Dose: 0.90 mL per animal • Reactions: Sudden death • Outcome: Died

  • Report ID: USA-USFDACVM-2026-US-014081
  • Serious AE: Yes
  • Treated For AE: No
  • Sex: Male
  • Age: 5.00 Year
  • Weight: 23.200 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Unknown
  • Form: Injection
  • Dose: 0.90 mL per animal
Reactions Reported:
Sudden death
Outcomes: Died

Dog, Pug, Unknown • Drug: MSK, Unassigned, Unknown • Reactions: Death, Cardiac arrest • Outcome: Died

  • Report ID: USA-USFDACVM-2026-US-012855
  • Serious AE: Yes
  • Treated For AE: No
  • Sex: Unknown
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Unknown
  • Form: Unassigned
Reactions Reported:
Death Cardiac arrest
Outcomes: Died

Dog, Bulldog - French, Unknown • Drug: MSK, Unassigned, Unknown • Reactions: Death, Cardiac arrest • Outcome: Died

  • Report ID: USA-USFDACVM-2026-US-012843
  • Serious AE: Yes
  • Treated For AE: No
  • Sex: Unknown
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Unknown
  • Form: Unassigned
Reactions Reported:
Death Cardiac arrest
Outcomes: Died

Cat, Domestic Longhair, Female, 5 month, 1.992 kilogram • Drug: MSK, Unknown • Reactions: Elevated temperature, Decreased body temperature • Outcome: Ongoing

  • Report ID: USA-USFDACVM-2026-US-012217
  • Serious AE: No
  • Treated For AE: Yes
  • Sex: Female
  • Age: 5.00 Month
  • Weight: 1.992 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Unknown
Reactions Reported:
Elevated temperature Decreased body temperature
Outcomes: Ongoing

Data source: FDA openFDA Animal & Veterinary adverse event reports.

Overdose Information

No approved overdose-management text is linked yet. If overdose is suspected, contact a veterinarian or emergency clinic immediately.

Storage & Handling

No approved storage guidance is linked yet for this ingredient. Use manufacturer packaging and veterinary guidance for handling/storage.

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This medication has not been reviewed by a veterinarian yet.