Skip to main content
Start triage

Start triage first, then route to emergency care.

Need urgent help? Start triage first, then route to emergency care.

Roxee Meds Catalog

Milbemcyin Oxime, Lufenuron, Praziquantel

Medication catalog facts with explicit FDA-approval, off-label, source-limited, and safety context.

Both Catalog complete FDA data linked Rx required Chewable Tablets Merck Sharp & Dohme Corp. Official label facts Owner quick guide first

Veterinary professional?

Showing simplified owner view. Switch to Vet View for full technical detail.

Data freshness

Storefront facts
Catalog refreshed
Apr 25, 2026, 10:05 a.m.

These are the storefront facts Roxee uses on browse cards and quick facts.

FDA applications
FDA application data refreshed
May 5, 2026, 10:00 a.m.

Sponsor, product, and application records imported from Animal Drugs @ FDA.

Safety reports
No safety reports linked
No refresh timestamp yet

openFDA reaction terms and case summaries are supporting evidence, not proof of causality.

Source timing details
Source timing details
  • Storefront facts: Source Roxee | Refreshed Apr 25, 2026, 10:05 AM UTC
    The storefront fact projection used for browse cards and quick facts.
  • Animal Drugs @ FDA: Source FDA | Refreshed May 5, 2026, 10:00 AM UTC
    Applications/products are imported from FDA export data.
  • Animal Drugs @ FDA previews: Source FDA | Refreshed Feb 9, 2026, 3:05 AM UTC
    Label highlights/doc links are fetched from FDA preview endpoints.

Evidence

Reviewed / Updated / Sources

Reviewed by: Not available

Last reviewed: April 22, 2026

Updated: April 22, 2026, 10:14 AM UTC

Sources:
Image coming soon
Milbemcyin Oxime, Lufenuron, Praziquantel

Milbemcyin Oxime, Lufenuron, Praziquantel

Drug type: Generic ingredient • Generic profile No FDA branded products linked

Both Chewable Tablets Rx required 100% storefront ready

Species: Both

Manufacturer: Merck Sharp & Dohme Corp.

Medication Snapshot

Merged from the current Roxee medication system with field-level provenance, freshness, and completeness tracking.

Milbemcyin Oxime, Lufenuron, Praziquantel

For the prevention of heartworm disease caused by Dirofilaria immitis ; for the prevention and control of flea populations ( Ctenocephalides felis ); and for the treatment and control of adult roundworm ( Toxocara canis , Toxascaris leonina ), adult hookworm ( Ancylostoma caninum ), adult whipworm ( Trichuris vulpis ), and adult tapeworm ( Dipylidium caninum , Taenia pisiformis , Echinococcus multilocularis and Echinococcus granulosus ) infections in dogs and puppies two pounds of body weight or greater and six weeks of age and older. Species commonly shown: Both, Dog, No Use Class Stated Or Implied.

Generic name
Milbemcyin Oxime, Lufenuron, Praziquantel
Brand names
Sentinel® Spectrum®
Manufacturer
Merck Sharp & Dohme Corp.
Species
Both, Dog, No Use Class Stated Or Implied
Dosage forms
Chewable Tablets
Prescription
Prescription required
Completeness
100%
Validation
Complete
Brand names
Sentinel® Spectrum®
Dosage forms
Chewable Tablets

Indications / Uses

For the prevention of heartworm disease caused by Dirofilaria immitis ; for the prevention and control of flea populations ( Ctenocephalides felis ); and for the treatment and control of adult roundworm ( Toxocara canis , Toxascaris leonina ), adult hookworm ( Ancylostoma caninum ), adult whipworm ( Trichuris vulpis ), and adult tapeworm ( Dipylidium caninum , Taenia pisiformis , Echinococcus multilocularis and Echinococcus granulosus ) infections in dogs and puppies two pounds of body weight or greater and six weeks of age and older.

Warnings / Contraindications

Federal law restricts this drug to use by or on the order of a licensed veterinarian.

  • Federal law restricts this drug to use by or on the order of a licensed veterinarian.

Side Effects

Top reported reactions (openFDA): INEFFECTIVE, HEARTWORM LARVAE, Vomiting, Lack of efficacy (endoparasite) - hookworm, INEFFECTIVE, ASCARIDS NOS, Diarrhoea, INEFFECTIVE, HOOKS.

FAQ

Both, Dog, No Use Class Stated Or Implied

Yes. Roxee shows this as prescription-only.

Chewable Tablets

Related Conditions

Source Transparency

Add to My Pet's Meds

Choose a pet, confirm current or past, and optionally add reminder notes.

Sign in to save this medication to your pet profile.

Sign in to continue

Pet Owner Quick Guide

Start here first for the safest next-step summary before the deeper medication detail.

Used for:

For the prevention of heartworm disease caused by Dirofilaria immitis ; for the prevention and control of flea populations ( Ctenocephalides felis ); and for the treatment and control of adult roundworm ( Toxocara canis...

Dosing note:

Exact dosing depends on your pet's species, weight, and health status. Use your veterinarian's instructions for the exact dose and schedule.

What to watch for:

  • wobbly/unsteady walking (1 reports)
  • Lack of efficacy - tapeworm (1 reports)
  • Inappetence (1 reports)

When to call the vet:

  • Repeated vomiting or diarrhea.
  • Severe lethargy (hard to wake, very low energy).
  • Collapse or fainting.
  • Trouble breathing.
  • Facial swelling or hives.
  • Blood in vomit or stool.

Regulatory restrictions are shown in Vet View.

What to tell or ask your vet today:

  • Is this medicine the right fit for my pet’s current symptoms?
  • Which warning signs mean I should call back right away?
  • How should I handle missed doses or refusal to take the medicine?
Major cautions & emergency warning signs

Side effects to monitor:

  • wobbly/unsteady walking
  • Lack of efficacy - tapeworm
  • Inappetence

Most reported reactions:

  • Unsteady walking (ataxia) (1 reports)
  • Lack of efficacy (endoparasite) - tapeworm (1 reports)
  • Inappetence (1 reports)

Emergency warning signs:

  • Repeated vomiting or diarrhea.
  • Severe lethargy (hard to wake, very low energy).
  • Collapse or fainting.
  • Trouble breathing.

Quick Facts

Official label facts first, then secondary summaries. Marketing content is separated below.

Species: Both
Manufacturer: Merck Sharp & Dohme Corp.
Form: Chewable Tablets
Identifiers:
NADA: 141333 NDC Package: 0061-5354-01 NDC Package: 0061-5354-02 NDC Package: 0061-5355-01 NDC Package: 0061-5355-02 NDC Package: 0061-5356-01 NDC Package: 0061-5356-02 NDC Package: 0061-5357-01 NDC Package: 0061-5357-02 NDC Product: 0061
Source metadata:

Warnings / Contraindications

Federal law restricts this drug to use by or on the order of a licensed veterinarian.

  • High: Federal law restricts this drug to use by or on the order of a licensed veterinarian.
Source metadata:

Adverse Reactions

Snapshot first, detailed rows second. This section summarizes signal data and is not a diagnosis.

Tap or hover a reaction to see what it means in plain language.

Tracked signals
32
Reported cases
32
Serious reports
11
Species represented
2
Grouped by Body System
Digestive (4) · Vomiting, Drooling, Diarrhea Skin & allergy (2) · Injection site swelling, Hair loss Neurologic (2) · Unsteady walking (ataxia), Grand mal seizure Behavior (1) · Behavioral disorder (unspecified) Effectiveness (7) · Lack of efficacy (endoparasite) - whipworm, Lack of efficacy (endoparasite) - tapeworm, Lack of efficacy (endoparasite) - roundworm NOS Other (16) · Inappetence, Hypochloraemia, Hiding
Most Reported Reactions
Reaction Body system Cases Species Serious cases
Neurologic 1 Cat 1
Effectiveness 1 Dog 1
Other 1 Cat 1
Neurologic 1 Cat 1
Other 1 Dog 1
Other 1 Cat 1
Other 1 Cat 1
Other 1 Cat 1

Species coverage: Dog (21) Cat (11)

View detailed reaction table
Reaction Body system Species Seriousness Frequency Reports
Digestive Cat Non-serious - 1
Neurologic Cat Serious - 1
Effectiveness Dog Non-serious - 1
Effectiveness Dog Serious - 1
Effectiveness Dog Non-serious - 1
Effectiveness Dog Non-serious - 1
Effectiveness Dog Non-serious - 1
Effectiveness Dog Non-serious - 1
Effectiveness Dog Non-serious - 1
Skin & allergy Dog Non-serious - 1
Other Cat Serious - 1
Other Dog Non-serious - 1
Other Cat Non-serious - 1
Other Dog Non-serious - 1
Skin & allergy Dog Non-serious - 1
Other Dog Non-serious - 1
Neurologic Cat Serious - 1
Other Dog Serious - 1
Other Cat Serious - 1
Other Dog Non-serious - 1
Other Cat Serious - 1
Digestive Cat Non-serious - 1
Other Cat Serious - 1
Other Cat Serious - 1
Digestive Dog Non-serious - 1
Other Dog Non-serious - 1
Other Dog Non-serious - 1
Other Dog Serious - 1
Digestive Dog Non-serious - 1
Behavior Dog Non-serious - 1
Other Dog Non-serious - 1
Other Cat Serious - 1
Source metadata:

Documents

Owner handouts and official technical documents open on-page first, with the original source still one click away.

Owner handouts

0
No owner handouts linked yet.

Official label / PI

0
No official label or package insert links yet.

SPL

2

FOI

2

Sentinel® Spectrum®

SPL · SPL

FDA Structured Product Label

Sentinel® Spectrum®

Rendered from Roxee's cached FDA SPL package contents for on-page reading. Use Open original for the raw FDA ZIP/XML source.

Sponsor
Intervet, Inc.
NADA
141-333
Status
RX
Form
Chewable Tablets
Route
Oral
Species
Dog, No Use Class Stated Or Implied
Composition / specifications
Each chewable tablet contains: 2.3 mg milbemycin oxime/46 mg lufenuron/22.8 mg praziquantel; 5.75 mg milbemycin oxime/115 mg lufenuron/57 mg praziquantel; 11.5 mg milbemycin oxime/230 mg lufenuron/114 mg praziquantel; 23.0 mg milbemycin oxime/460 mg lufenuron/228 mg praziquantel

Dogs

Indication

For the prevention of heartworm disease caused by Dirofilaria immitis; for the prevention and control of flea populations (Ctenocephalides felis); and for the treatment and control of adult roundworm (Toxocara canis, Toxascaris leonina), adult hookworm (Ancylostoma caninum), adult whipworm (Trichuris vulpis), and adult tapeworm (Dipylidium caninum,Taenia pisiformis, Echinococcus multilocularis and Echinococcus granulosus) infections in dogs and puppies two pounds of body weight or greater and six weeks of age and older.

Dosage

SENTINEL SPECTRUM is given orally, once a month, at the minimum dosage of 0.23 mg/pound body weight (0.5 mg/kg) of milbemycin oxime, 4.55 mg/pound (10 mg/kg) of lufenuron, and 2.28 mg/pound (5 mg/kg) of praziquantel. For heartworm prevention, give once monthly beginning within 1 month of the dog’s first seasonal exposure to mosquitoes and continuing until at least 6 months after the dog’s last seasonal exposure.

Limitations

Federal law restricts this drug to use by or on the order of a licensed veterinarian.

Sentinel Spectrum SPL

SPL · Structured Product Label

FDA Structured Product Label XML for Sentinel Spectrum. Use the source link for the full official labeling record.

FOI Summary sN-141-333 Approved September 28, 2017.pdf

FOI · FOI

UCM292003.pdf

FOI · FOI

Veterinary reference (advanced)

Canonical medication sections are above. This legacy block remains available for deeper cross-reference without cluttering the primary workflow.

At a Glance

Quick facts and links to official labeling and safety signals.

Data freshness
  • Storefront facts: Source Roxee | Refreshed Apr 25, 2026, 10:05 AM UTC
    The storefront fact projection used for browse cards and quick facts.
  • Animal Drugs @ FDA: Source FDA | Refreshed May 5, 2026, 10:00 AM UTC
    Applications/products are imported from FDA export data.
  • Animal Drugs @ FDA previews: Source FDA | Refreshed Feb 9, 2026, 3:05 AM UTC
    Label highlights/doc links are fetched from FDA preview endpoints.
Official (FDA)
Identity: Generic ingredient • No FDA branded products linked
No official FDA brand rows linked yet for this ingredient.
Manufacturer mapping: Merck Sharp & Dohme Corp.
Catalog species: Both FDA-labeled species: Dog
Rx/OTC: RX
Form/route: Chewable Tablets Oral
Applications: NADA 141-333
Documents: 2 (FOI: 2) • SPL: 1 Label highlights Official documents
Safety (openFDA)
Top reactions: Dog 0 Cat 0 View
Case summaries: 0
openFDA reports are unverified and do not prove causation.

Explore
Related conditions: Heartworm Disease
Linked using: Fda_Label (0.95)

Diagnosis Codes
ICD10_CM: B74.8
Other filariases

Counseling and Monitoring Highlights

Global Pet owner/Vet mode is controlled in the header. This section avoids duplicate in-page persona tabs.

Owner-facing counseling points
  • Federal law restricts this drug to use by or on the order of a licensed veterinarian. (Contraindication, High)
Top reaction signals
Unsteady walking (ataxia) (1) Lack of efficacy (endoparasite) - tapeworm (1) Inappetence (1) Grand mal seizure (1) Fracture (1) Fever (1) Dysphoria (1) Disorientation (1)

Identifiers & Packages

Normalized identifiers (NDC/NADA/ANADA) and package metadata from regulator listings.

Identifiers
NADA: 141333 NDC Package: 0061-5354-01 NDC Package: 0061-5354-02 NDC Package: 0061-5355-01 NDC Package: 0061-5355-02 NDC Package: 0061-5356-01 NDC Package: 0061-5356-02 NDC Package: 0061-5357-01 NDC Package: 0061-5357-02 NDC Product: 0061
Package NDC Product NDC Form / Route Status
0061-5354-01 0061 -
0061-5354-02 0061 -
0061-5355-01 0061 -
0061-5355-02 0061 -
0061-5356-01 0061 -
0061-5356-02 0061 -
0061-5357-01 0061 -
0061-5357-02 0061 -

Enriched Documents

Documents are tiered by source trust: Official, Clinical, Manufacturer, Marketing.

Data Sources & Change Log

Every non-trivial field is expected to include provenance and update timestamps.

Official 19 Clinical 4 Manufacturer 0 Marketing 0
Current Field Facts
  • side_effects: Top reported reactions (openFDA): INEFFECTIVE, HEARTWORM LARVAE, Vomiting, Lack of efficacy (endoparasite) - hookworm, INEFFECTIVE, ASCARIDS NOS, Diarrhoea, IN… (Clinical, 2026-04-25)
  • side_effects: Top reported reactions (openFDA): INEFFECTIVE, HEARTWORM LARVAE, Vomiting, Lack of efficacy (endoparasite) - hookworm, INEFFECTIVE, ASCARIDS NOS, Diarrhoea, IN… (Clinical, 2026-04-22)
  • side_effects: Top reported reactions (openFDA): INEFFECTIVE, HEARTWORM LARVAE, Vomiting, Lack of efficacy (endoparasite) - hookworm, INEFFECTIVE, ASCARIDS NOS, Diarrhoea, IN… (Clinical, 2026-04-15)
  • side_effects: Top reported reactions (openFDA): INEFFECTIVE, HEARTWORM LARVAE, Vomiting, Lack of efficacy (endoparasite) - hookworm, INEFFECTIVE, ASCARIDS NOS, Diarrhoea, IN… (Clinical, 2026-04-11)
  • contraindications: Federal law restricts this drug to use by or on the order of a licensed veterinarian. (Official, 2026-04-25)
  • contraindications: Federal law restricts this drug to use by or on the order of a licensed veterinarian. (Official, 2026-04-22)
  • indications: For the prevention of heartworm disease caused by Dirofilaria immitis; for the prevention and control of flea populations (Ctenocephalides felis); and for the … (Official, 2026-05-05)
  • indications: For the prevention of heartworm disease caused by Dirofilaria immitis; for the prevention and control of flea populations (Ctenocephalides felis); and for the … (Official, 2026-05-03)
  • indications: For the prevention of heartworm disease caused by Dirofilaria immitis; for the prevention and control of flea populations (Ctenocephalides felis); and for the … (Official, 2026-05-02)
  • indications: For the prevention of heartworm disease caused by Dirofilaria immitis; for the prevention and control of flea populations (Ctenocephalides felis); and for the … (Official, 2026-04-29)
  • indications: For the prevention of heartworm disease caused by Dirofilaria immitis; for the prevention and control of flea populations (Ctenocephalides felis); and for the … (Official, 2026-04-28)
  • indications: For the prevention of heartworm disease caused by Dirofilaria immitis; for the prevention and control of flea populations (Ctenocephalides felis); and for the … (Official, 2026-04-27)
  • indications: For the prevention of heartworm disease caused by Dirofilaria immitis; for the prevention and control of flea populations (Ctenocephalides felis); and for the … (Official, 2026-04-26)
  • indications: For the prevention of heartworm disease caused by Dirofilaria immitis; for the prevention and control of flea populations (Ctenocephalides felis); and for the … (Official, 2026-04-25)
  • indications: For the prevention of heartworm disease caused by Dirofilaria immitis; for the prevention and control of flea populations (Ctenocephalides felis); and for the … (Official, 2026-04-22)
  • manufacturer_name: Merck Sharp & Dohme Corp. (Official, 2026-04-22)
  • prescription_required: Rx required (Official, 2026-04-22)
  • side_effects: Top reported reactions (openFDA): INEFFECTIVE, HEARTWORM LARVAE, Vomiting, Lack of efficacy (endoparasite) - hookworm, INEFFECTIVE, ASCARIDS NOS, Diarrhoea, IN… (Official, 2026-02-12)
  • usage: For the prevention of heartworm disease caused by Dirofilaria immitis ; for the prevention and control of flea populations ( Ctenocephalides felis ); and for t… (Official, 2026-04-25)
  • usage: For the prevention of heartworm disease caused by Dirofilaria immitis ; for the prevention and control of flea populations ( Ctenocephalides felis ); and for t… (Official, 2026-04-22)
Recent Revisions
  • side_effects updated 2026-04-25 10:05 by etl_backfill • Backfilled from existing medication fields
  • contraindications updated 2026-04-25 10:05 by etl_backfill • Backfilled from existing medication fields
  • usage updated 2026-04-25 10:05 by etl_backfill • Backfilled from existing medication fields
  • side_effects updated 2026-04-22 10:14 by etl_backfill • Backfilled from existing medication fields
  • contraindications updated 2026-04-22 10:14 by etl_backfill • Backfilled from existing medication fields
  • usage updated 2026-04-22 10:14 by etl_backfill • Backfilled from existing medication fields
  • side_effects updated 2026-04-15 10:04 by etl_backfill • Backfilled from existing medication fields
  • side_effects updated 2026-04-11 10:05 by etl_backfill • Backfilled from existing medication fields
  • side_effects updated 2026-02-12 22:44 by etl_backfill • Backfilled from existing medication fields

FDA Products & Applications (Animal Drugs @ FDA)

Official sponsor/proprietary-name/application-status records linked by active ingredient.

Product Sponsor Application Status Published
Sentinel® Spectrum®
RX
Lufenuron Milbemycin Oxime Praziquantel
Chewable Tablets Oral
Intervet, Inc. NADA 141-333 Approved Aug 3, 2020

Data source: FDA Animal Drugs @ FDA (public search export).

What It's For (FDA Label Highlights)

Extracted from FDA Animal Drugs @ FDA product labeling. Always confirm details with your veterinarian.

Species: Dog, No Use Class Stated Or Implied
Composition / specifications
Each chewable tablet contains: 2.3 mg milbemycin oxime/46 mg lufenuron/22.8 mg praziquantel; 5.75 mg milbemycin oxime/115 mg lufenuron/57 mg praziquantel; 11.5 mg milbemycin oxime/230 mg lufenuron/114 mg praziquantel; 23.0 mg milbemycin oxime/460 mg lufenuron/228 mg praziquantel
Dogs
Indication

For the prevention of heartworm disease caused by Dirofilaria immitis; for the prevention and control of flea populations (Ctenocephalides felis); and for the treatment and control of adult roundworm (Toxocara canis, Toxascaris leonina), adult hookworm (Ancylostoma caninum), adult whipworm (Trichuris vulpis), and adult tapeworm (Dipylidium caninum,Taenia pisiformis, Echinococcus multilocularis and Echinococcus granulosus) infections in dogs and puppies two pounds of body weight or greater and six weeks of age and older.

Dosage

SENTINEL SPECTRUM is given orally, once a month, at the minimum dosage of 0.23 mg/pound body weight (0.5 mg/kg) of milbemycin oxime, 4.55 mg/pound (10 mg/kg) of lufenuron, and 2.28 mg/pound (5 mg/kg) of praziquantel. For heartworm prevention, give once monthly beginning within 1 month of the dog’s first seasonal exposure to mosquitoes and continuing until at least 6 months after the dog’s last seasonal exposure.

Limitations

Federal law restricts this drug to use by or on the order of a licensed veterinarian.

FDA page: Open in Animal Drugs @ FDA

Usage

For the prevention of heartworm disease caused by Dirofilaria immitis ; for the prevention and control of flea populations ( Ctenocephalides felis ); and for the treatment and control of adult roundworm ( Toxocara canis , Toxascaris leonina ), adult hookworm ( Ancylostoma caninum ), adult whipworm ( Trichuris vulpis ), and adult tapeworm ( Dipylidium caninum , Taenia pisiformis , Echinococcus multilocularis and Echinococcus granulosus ) infections in dogs and puppies two pounds of body weight or greater and six weeks of age and older.

Source: FDA Animal Drugs @ FDA • Reference

Contraindications

Federal law restricts this drug to use by or on the order of a licensed veterinarian.

Top Reported Reactions (openFDA)

De-duplicated reaction terms grouped by body system from FDA openFDA reports (not verified; does not prove causation).

Digestive
Vomiting (1) • Cat Drooling (1) • Cat Diarrhea (1) • Dog Bloody diarrhoea (1) • Dog

Showing top 5 for Digestive.

Skin & allergy
Injection site swelling (1) • Dog Hair loss (1) • Dog

Showing top 5 for Skin & allergy.

Neurologic
Unsteady walking (1) • Cat Grand mal seizure (1) • Cat

Showing top 5 for Neurologic.

Behavior
Behavioral disorder (1) • Dog

Showing top 5 for Behavior.

Effectiveness
Lack of efficacy (endoparasite) - whipworm (1) • Dog Lack of efficacy (endoparasite) - tapeworm (1) • Dog Lack of efficacy (endoparasite) - roundworm NOS (1) • Dog Lack of efficacy (endoparasite) - hookworm (1) • Dog Lack of efficacy (endoparasite) - heartworm (1) • Dog
Show more (2)
Lack of efficacy (bacteria) - Ehrlichia (1) • Dog Lack of efficacy (bacteria) - Anaplasma (1) • Dog

Showing top 5 for Effectiveness.

Other
Inappetence (1) • Cat Hypochloraemia (1) • Dog Hiding (1) • Cat Head shake - ear disorder (1) • Dog Haemorrhagic gastroenteritis (1) • Dog
Show more (11)
Fracture (1) • Dog Fever (1) • Cat Ear infection NOS (1) • Dog Dysphoria (1) • Cat Disorientation (1) • Cat Dilated pupils (1) • Cat Cough (1) • Dog Constipation (1) • Dog Conjunctivitis (1) • Dog Bacterial skin infection NOS (1) • Dog Accidental exposure (1) • Cat

Showing top 5 for Other.

Data source: FDA openFDA Animal & Veterinary adverse event reports.

Adverse Event Case Summaries (openFDA)

These are individual FDA adverse event reports. They are unverified and do not prove the medication caused the reaction.

No case-level openFDA reports are linked for this medication yet.

Data source: FDA openFDA Animal & Veterinary adverse event reports.

Overdose Information

No approved overdose-management text is linked yet. If overdose is suspected, contact a veterinarian or emergency clinic immediately.

Storage & Handling

No approved storage guidance is linked yet for this ingredient. Use manufacturer packaging and veterinary guidance for handling/storage.

Share Your Thoughts

Let others know your experience or advice regarding this medication.

This medication has not been reviewed by a veterinarian yet.