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Roxee Medication Guide

Milbemycin/Lufenuron/Pzq Chew

Medication reference facts with explicit FDA-approval, off-label, source-limited, and safety context. Roxee does not sell, prescribe, or dispense medications.

Both Reference complete FDA data linked Rx required Chewable Tablets Merck Sharp & Dohme Corp. Official label facts Owner quick guide first
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Data freshness

Reference facts
Reference refreshed
Jun 22, 2026, 10:40 a.m.

These are the reference facts Roxee uses on browse cards and quick facts.

FDA applications
FDA application data refreshed
Jun 22, 2026, 10:40 a.m.

Sponsor, product, and application records imported from Animal Drugs @ FDA.

Safety reports
No safety reports linked
No refresh timestamp yet

openFDA reaction terms and case summaries are supporting evidence, not proof of causality.

Source timing details
Source timing details
  • Reference facts: Source Roxee | Refreshed Jun 22, 2026, 10:40 AM UTC
    The reference fact projection used for browse cards and quick facts.
  • Animal Drugs @ FDA: Source FDA | Refreshed Jun 22, 2026, 10:40 AM UTC
    Applications/products are imported from FDA export data.
  • Animal Drugs @ FDA previews: Source FDA | Refreshed Feb 9, 2026, 3:05 AM UTC
    Label highlights/doc links are fetched from FDA preview endpoints.
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Milbemycin/Lufenuron/Pzq Chew

Milbemycin/Lufenuron/Pzq Chew

Drug type: Generic ingredient • Generic profile • No FDA branded products linked

Both Chewable Tablets Rx required 100% reference complete

Species: Both

Manufacturer: Merck Sharp & Dohme Corp.

Medication Snapshot

Merged from the current Roxee medication system with field-level provenance, freshness, and completeness tracking.

Milbemycin/Lufenuron/Pzq Chew

For the prevention of heartworm disease caused by Dirofilaria immitis ; for the prevention and control of flea populations ( Ctenocephalides felis ); and for the treatment and control of adult roundworm ( Toxocara canis, Toxascaris leonina ), adult hookworm ( Ancylostoma caninum ), adult whipworm ( Trichuris vulpis ), and adult tapeworm ( Dipylidium caninum, Taenia pisiformis, Echinococcus multilocularis and Echinococcus granulosus ) infections in dogs and puppies two pounds of body weight or greater and six weeks of age and older. Species commonly shown: Both, Dog.

Generic name
Milbemycin/Lufenuron/Pzq Chew
Brand names
Sentinel® Spectrum®
Manufacturer
Merck Sharp & Dohme Corp.
Species
Both, Dog
Dosage forms
Chewable Tablets
Prescription
Prescription required
Completeness
100%
Validation
Needs review
Brand names
Sentinel® Spectrum®
Dosage forms
Chewable Tablets

Indications / Uses

For the prevention of heartworm disease caused by Dirofilaria immitis ; for the prevention and control of flea populations ( Ctenocephalides felis ); and for the treatment and control of adult roundworm ( Toxocara canis , Toxascaris leonina ), adult hookworm ( Ancylostoma caninum ), adult whipworm ( Trichuris vulpis ), and adult tapeworm ( Dipylidium caninum , Taenia pisiformis , Echinococcus multilocularis and Echinococcus granulosus ) infections in dogs and puppies two pounds of body weight or greater and six weeks of age and older.

Warnings / Contraindications

Federal law restricts this drug to use by or on the order of a licensed veterinarian.

  • Federal law restricts this drug to use by or on the order of a licensed veterinarian.

Side Effects

Top reported reactions (openFDA): Lack of efficacy (endoparasite) - heartworm, Lack of efficacy (endoparasite) - hookworm, Vomiting, Lack of efficacy (endoparasite) - roundworm NOS, Lack of efficacy (ectoparasite) - flea, Emesis (multiple).

FAQ

Both, Dog

Yes. Roxee shows this as prescription-only.

Chewable Tablets

Related Conditions

Heartworm Disease

Source Transparency

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Pet Owner Quick Guide

Start here first for the safest next-step summary before the deeper medication detail.

Used for:

For the prevention of heartworm disease caused by Dirofilaria immitis ; for the prevention and control of flea populations ( Ctenocephalides felis ); and for the treatment and control of adult roundworm ( Toxocara canis...

Dosing note:

Exact dosing depends on your pet's species, weight, and health status. Use your veterinarian's instructions for the exact dose and schedule.

What to watch for:

  • Lack of efficacy - hookworm (1 reports)
  • Lack of efficacy - heartworm (1 reports)
  • Lack of efficacy - Borrelia (1 reports)

When to call the vet:

  • Repeated vomiting or diarrhea.
  • Severe lethargy (hard to wake, very low energy).
  • Collapse or fainting.
  • Trouble breathing.
  • Facial swelling or hives.
  • Blood in vomit or stool.

Regulatory restrictions are shown in Vet View.

What to tell or ask your vet today:

  • Is this medicine the right fit for my pet’s current symptoms?
  • Which warning signs mean I should call back right away?
  • How should I handle missed doses or refusal to take the medicine?

Next actions

Talk to a Vet / Find a Vet Near You Save to pet meds Share page Review report evidence
Research brief

Medication Research Insights

A source-aware map of what to know, what is uncertain, and what to verify with your veterinarian.

Source Backed Signals

What to know

Evidence-backed context Limited

Roxee has limited cited overview evidence for Milbemycin/Lufenuron/Pzq Chew; use the official documents and your veterinarian's instructions for product-specific decisions.

Source: openFDA case USA-USFDACVM-2025-US-070191
Safety signal coverage Reported signals

32 tracked reaction signals; 32 reported cases; 14 serious reports; 2 species groups. These are reporting and label-derived signals for interpretation with a veterinarian.

Source: openFDA case USA-USFDACVM-2025-US-070191
Interpretation guardrail Not causation

Adverse-event reports help form a watch list, but they do not prove the medication caused the reaction and they are not a risk ranking between medications.

Evidence tension

Stronger signal Label / review

Official labels, package inserts, and reviewed summaries carry more weight than isolated reports.

Source: openFDA case USA-USFDACVM-2025-US-070191
Weaker signal Reported data

Case reports and openFDA terms are useful for pattern awareness, but they are incomplete, can include multiple exposures, and do not estimate an individual pet's probability of harm.

Reaction signal map

Most reported reactions Top terms

Lack of efficacy (endoparasite) - hookworm (1 reports), Lack of efficacy (endoparasite) - heartworm (1 reports), Lack of efficacy (bacteria) - Borrelia (1 reports), Itching (1 reports), Increased seizure frequency (1 reports)

Body systems represented Signal grouping

Digestive (4), Skin & allergy (4), Neurologic (3), Behavior (1)

Species and breed lens

Species represented in reports Species lens

Dog (26 reports), Cat (6 reports)

What your vet may verify

Fit for this patient Vet check

Verify whether Milbemycin/Lufenuron/Pzq Chew fits the pet's species, current diagnosis, age, weight, organ status, pregnancy/lactation status, and concurrent medications.

Evidence limitations Evidence review

Separate label-backed warnings from adverse-event reports and owner observations before changing the plan.

What to watch next

Watch list Owner-safe

Lack of efficacy - hookworm, Lack of efficacy - heartworm, Lack of efficacy - Borrelia

Call sooner if Escalation

Repeated vomiting or diarrhea. Severe lethargy (hard to wake, very low energy). Collapse or fainting.

Bottom line: Use this Milbemycin/Lufenuron/Pzq Chew brief as a structured watch list and source map, not as a reason to start, stop, or change treatment without your veterinarian.
Vet source depth
  1. openFDA case USA-USFDACVM-2025-US-070191 · adverse_reaction · adverse reactions
  2. Contraindication source · fda_animal_drugs · warnings contraindications
  3. FDA application profile · official_label · quick facts
  4. Medication usage source · fda_animal_drugs · quick facts
  5. FOI · document · documents
  6. FOI · document · documents
  7. SPL · document · documents
  8. Structured Product Label · document · documents

Evidence

Review status / Updated / Sources

Review status: Clinical reviewer not listed

Updated: April 22, 2026, 10:14 AM UTC

Sources:
Safety & side effects

Side effects to monitor:

  • Lack of efficacy - hookworm
  • Lack of efficacy - heartworm
  • Lack of efficacy - Borrelia

Most reported reactions:

  • Lack of efficacy (endoparasite) - hookworm (1 reports)
  • Lack of efficacy (endoparasite) - heartworm (1 reports)
  • Lack of efficacy (bacteria) - Borrelia (1 reports)

Emergency warning signs:

  • Repeated vomiting or diarrhea.
  • Severe lethargy (hard to wake, very low energy).
  • Collapse or fainting.
  • Trouble breathing.
Talk to a Vet / Find a Vet Near You Start Symptom Intake

Vet Fast Scan

Source-backed clinical checkpoints for quick review.

FDA-labeled species
Dog
Indication / use
For the prevention of heartworm disease caused by Dirofilaria immitis ; for the prevention and control of flea populations ( Ctenocephalides felis ); and for the treatment and con…
Form / route / dose
Form: Chewable Tablets
Route: Oral
Confirm product label and patient-specific plan.
Warnings
  • High: Federal law restricts this drug to use by or on the order of a licensed veterinarian.
Adverse-event caveat
No stored openFDA case explorer rows are linked yet.
Source docs

Quick Facts

Official label facts first, then secondary summaries. Marketing content is separated below.

Species: Both
Manufacturer: Merck Sharp & Dohme Corp.
Form: Chewable Tablets
Identifiers:
NADA: 141333 NDC Package: 0061-5354-01 NDC Package: 0061-5354-02 NDC Package: 0061-5355-01 NDC Package: 0061-5355-02 NDC Package: 0061-5356-01 NDC Package: 0061-5356-02 NDC Package: 0061-5357-01 NDC Package: 0061-5357-02 NDC Product: 0061
Source metadata:

Warnings / Contraindications

Federal law restricts this drug to use by or on the order of a licensed veterinarian.

  • High: Federal law restricts this drug to use by or on the order of a licensed veterinarian.
Source metadata:

Adverse Reactions

Snapshot first, detailed rows second. This section summarizes signal data and is not a diagnosis.

Tap or hover a reaction to see what it means in plain language.

Tracked signals
32
Reported cases
32
Serious reports
14
Species represented
2
Grouped by Body System
Digestive (4) · Vomiting, Drooling, Diarrhea Skin & allergy (4) · Itching, Injection site swelling, Hair loss Neurologic (3) · Unsteady walking (ataxia), Increased seizure frequency, Grand mal seizure Behavior (1) · Behavioral disorder (unspecified) Effectiveness (6) · Lack of efficacy (endoparasite) - roundworm NOS, Lack of efficacy (endoparasite) - hookworm, Lack of efficacy (endoparasite) - heartworm Other (14) · Hypochloraemia, Hiding, Head shake - ear disorder
Most Reported Reactions
Reaction Body system Cases Species Serious cases
Effectiveness 1 Dog 1
Effectiveness 1 Dog 1
Effectiveness 1 Dog 1
Skin & allergy 1 Dog 1
Neurologic 1 Dog 1
Neurologic 1 Cat 1
Other 1 Dog 1
Other 1 Cat 1

Species coverage: Dog (26) Cat (6)

View detailed reaction table
Reaction Body system Species Seriousness Frequency Reports
Digestive Cat Non-serious - 1
Neurologic Dog Non-serious - 1
Effectiveness Dog Non-serious - 1
Effectiveness Dog Serious - 1
Effectiveness Dog Serious - 1
Effectiveness Dog Non-serious - 1
Effectiveness Dog Serious - 1
Effectiveness Dog Non-serious - 1
Skin & allergy Dog Serious - 1
Skin & allergy Dog Non-serious - 1
Neurologic Dog Serious - 1
Other Dog Non-serious - 1
Other Cat Non-serious - 1
Other Dog Non-serious - 1
Skin & allergy Dog Non-serious - 1
Other Dog Non-serious - 1
Neurologic Cat Serious - 1
Other Dog Serious - 1
Other Cat Serious - 1
Other Dog Non-serious - 1
Other Cat Serious - 1
Digestive Dog Serious - 1
Other Cat Serious - 1
Digestive Dog Non-serious - 1
Other Dog Serious - 1
Other Dog Non-serious - 1
Other Dog Non-serious - 1
Other Dog Serious - 1
Digestive Dog Non-serious - 1
Skin & allergy Dog Serious - 1
Behavior Dog Non-serious - 1
Other Dog Non-serious - 1
Source metadata:

Source Documents

The most useful source links appear first; full previews and metadata stay in the veterinary/professional layer.

Use original documents to confirm product-specific warnings, ingredients, and handling details with your veterinarian.

Sentinel® Spectrum® SPL · SPL Sentinel Spectrum SPL SPL · Structured Product Label FOI Summary sN-141-333 Approved September 28, 2017.pdf FOI · FOI

Full source previews and metadata remain in the veterinary/professional layer.

Owner handouts

0
No owner handouts linked yet.

Official label / PI

0
No official label or package insert links yet.

SPL

2

FOI

2

Sentinel® Spectrum®

SPL · SPL

Open original
FDA Structured Product Label

Sentinel® Spectrum®

Rendered from Roxee's cached FDA SPL package contents for on-page reading. Use Open original for the raw FDA ZIP/XML source.

Sponsor
Intervet, Inc.
NADA
141-333
Status
RX
Form
Chewable Tablets
Route
Oral
Species
Dog
Composition / specifications
Each chewable tablet contains: 2.3 mg milbemycin oxime/46 mg lufenuron/22.8 mg praziquantel; 5.75 mg milbemycin oxime/115 mg lufenuron/57 mg praziquantel; 11.5 mg milbemycin oxime/230 mg lufenuron/114 mg praziquantel; 23.0 mg milbemycin oxime/460 mg lufenuron/228 mg praziquantel

Dogs

Indication

For the prevention of heartworm disease caused by Dirofilaria immitis; for the prevention and control of flea populations (Ctenocephalides felis); and for the treatment and control of adult roundworm (Toxocara canis, Toxascaris leonina), adult hookworm (Ancylostoma caninum), adult whipworm (Trichuris vulpis), and adult tapeworm (Dipylidium caninum,Taenia pisiformis, Echinococcus multilocularis and Echinococcus granulosus) infections in dogs and puppies two pounds of body weight or greater and six weeks of age and older.

Dosage

SENTINEL SPECTRUM is given orally, once a month, at the minimum dosage of 0.23 mg/pound body weight (0.5 mg/kg) of milbemycin oxime, 4.55 mg/pound (10 mg/kg) of lufenuron, and 2.28 mg/pound (5 mg/kg) of praziquantel. For heartworm prevention, give once monthly beginning within 1 month of the dog’s first seasonal exposure to mosquitoes and continuing until at least 6 months after the dog’s last seasonal exposure.

Limitations

Federal law restricts this drug to use by or on the order of a licensed veterinarian.

Sentinel Spectrum SPL

SPL · Structured Product Label

Open original
FDA Structured Product Label XML for Sentinel Spectrum. Use the source link for the full official labeling record.

FOI Summary sN-141-333 Approved September 28, 2017.pdf

FOI · FOI

Open original

UCM292003.pdf

FOI · FOI

Open original
Source metadata:
Veterinary reference (advanced)

Canonical medication sections are above. This legacy block remains available for deeper cross-reference without cluttering the primary workflow.

At a Glance

Quick facts and links to official labeling and safety signals.

Data freshness
  • Reference facts: Source Roxee | Refreshed Jun 22, 2026, 10:40 AM UTC
    The reference fact projection used for browse cards and quick facts.
  • Animal Drugs @ FDA: Source FDA | Refreshed Jun 22, 2026, 10:40 AM UTC
    Applications/products are imported from FDA export data.
  • Animal Drugs @ FDA previews: Source FDA | Refreshed Feb 9, 2026, 3:05 AM UTC
    Label highlights/doc links are fetched from FDA preview endpoints.
Official (FDA)
Identity: Generic ingredient • No FDA branded products linked
No official FDA brand rows linked yet for this ingredient.
Manufacturer mapping: Merck Sharp & Dohme Corp.
Catalog species: Both • FDA-labeled species: Dog
Rx/OTC: RX
Form/route: Chewable Tablets • Oral
Applications: NADA 141-333
Documents: 2 (FOI: 2) • SPL: 1 • Label highlights • Official documents
Safety (openFDA)
Top reactions: Dog 0 • Cat 0 • View
Case summaries: 0
openFDA reports are unverified and do not prove causation.
Explore
Related conditions: Heartworm Disease
Linked using: Fda_Label (0.95)
Diagnosis Codes
ICD10_CM: B74.8
Other filariases

Counseling and Monitoring Highlights

Global Pet owner/Vet mode is controlled in the header. This section avoids duplicate in-page persona tabs.

Owner-facing counseling points
  • Federal law restricts this drug to use by or on the order of a licensed veterinarian. (Contraindication, High)
Top reaction signals
Lack of efficacy (endoparasite) - hookworm (1) Lack of efficacy (endoparasite) - heartworm (1) Lack of efficacy (bacteria) - Borrelia (1) Itching (1) Increased seizure frequency (1) Grand mal seizure (1) Fracture (1) Fever (1)

Identifiers & Packages

Normalized identifiers (NDC/NADA/ANADA) and package metadata from regulator listings.

Identifiers
NADA: 141333 NDC Package: 0061-5354-01 NDC Package: 0061-5354-02 NDC Package: 0061-5355-01 NDC Package: 0061-5355-02 NDC Package: 0061-5356-01 NDC Package: 0061-5356-02 NDC Package: 0061-5357-01 NDC Package: 0061-5357-02 NDC Product: 0061
Package NDC Product NDC Form / Route Status
0061-5354-01 0061 -
0061-5354-02 0061 -
0061-5355-01 0061 -
0061-5355-02 0061 -
0061-5356-01 0061 -
0061-5356-02 0061 -
0061-5357-01 0061 -
0061-5357-02 0061 -

Enriched Documents

Documents are tiered by source trust: Official, Clinical, Manufacturer, Marketing.

Data Sources & Change Log

Every non-trivial field is expected to include provenance and update timestamps.

Official 76 Clinical 5 Manufacturer 0 Marketing 0
Current Field Facts
  • side_effects: Top reported reactions (openFDA): Lack of efficacy (endoparasite) - heartworm, Lack of efficacy (endoparasite) - hookworm, Vomiting, Lack of efficacy (endopara… (Clinical, 2026-05-02)
  • side_effects: Top reported reactions (openFDA): Lack of efficacy (endoparasite) - heartworm, Lack of efficacy (endoparasite) - hookworm, Vomiting, Lack of efficacy (endopara… (Clinical, 2026-04-25)
  • side_effects: Top reported reactions (openFDA): Lack of efficacy (endoparasite) - heartworm, Lack of efficacy (endoparasite) - hookworm, Vomiting, Lack of efficacy (endopara… (Clinical, 2026-04-22)
  • side_effects: Top reported reactions (openFDA): Lack of efficacy (endoparasite) - heartworm, Lack of efficacy (endoparasite) - hookworm, Vomiting, Lack of efficacy (endopara… (Clinical, 2026-04-15)
  • side_effects: Top reported reactions (openFDA): Lack of efficacy (endoparasite) - heartworm, Lack of efficacy (endoparasite) - hookworm, Vomiting, Lack of efficacy (endopara… (Clinical, 2026-04-11)
  • contraindications: Federal law restricts this drug to use by or on the order of a licensed veterinarian. (Official, 2026-05-02)
  • contraindications: Federal law restricts this drug to use by or on the order of a licensed veterinarian. (Official, 2026-04-30)
  • contraindications: Federal law restricts this drug to use by or on the order of a licensed veterinarian. (Official, 2026-04-25)
  • contraindications: Federal law restricts this drug to use by or on the order of a licensed veterinarian. (Official, 2026-04-22)
  • indications: For the prevention of heartworm disease caused by Dirofilaria immitis; for the prevention and control of flea populations (Ctenocephalides felis); and for the … (Official, 2026-06-22)
  • indications: For the prevention of heartworm disease caused by Dirofilaria immitis; for the prevention and control of flea populations (Ctenocephalides felis); and for the … (Official, 2026-06-22)
  • indications: For the prevention of heartworm disease caused by Dirofilaria immitis; for the prevention and control of flea populations (Ctenocephalides felis); and for the … (Official, 2026-06-21)
  • indications: For the prevention of heartworm disease caused by Dirofilaria immitis; for the prevention and control of flea populations (Ctenocephalides felis); and for the … (Official, 2026-06-20)
  • indications: For the prevention of heartworm disease caused by Dirofilaria immitis; for the prevention and control of flea populations (Ctenocephalides felis); and for the … (Official, 2026-06-13)
  • indications: For the prevention of heartworm disease caused by Dirofilaria immitis; for the prevention and control of flea populations (Ctenocephalides felis); and for the … (Official, 2026-06-12)
  • indications: For the prevention of heartworm disease caused by Dirofilaria immitis; for the prevention and control of flea populations (Ctenocephalides felis); and for the … (Official, 2026-06-12)
  • indications: For the prevention of heartworm disease caused by Dirofilaria immitis; for the prevention and control of flea populations (Ctenocephalides felis); and for the … (Official, 2026-06-11)
  • indications: For the prevention of heartworm disease caused by Dirofilaria immitis; for the prevention and control of flea populations (Ctenocephalides felis); and for the … (Official, 2026-06-11)
  • indications: For the prevention of heartworm disease caused by Dirofilaria immitis; for the prevention and control of flea populations (Ctenocephalides felis); and for the … (Official, 2026-06-10)
  • indications: For the prevention of heartworm disease caused by Dirofilaria immitis; for the prevention and control of flea populations (Ctenocephalides felis); and for the … (Official, 2026-06-09)
Recent Revisions
  • side_effects updated 2026-05-02 10:05 by etl_backfill • Backfilled from existing medication fields
  • contraindications updated 2026-05-02 10:05 by etl_backfill • Backfilled from existing medication fields
  • usage updated 2026-05-02 10:05 by etl_backfill • Backfilled from existing medication fields
  • side_effects updated 2026-04-30 10:09 by etl_backfill • Backfilled from existing medication fields
  • contraindications updated 2026-04-30 10:09 by etl_backfill • Backfilled from existing medication fields
  • usage updated 2026-04-30 10:09 by etl_backfill • Backfilled from existing medication fields
  • side_effects updated 2026-04-25 10:05 by etl_backfill • Backfilled from existing medication fields
  • contraindications updated 2026-04-25 10:05 by etl_backfill • Backfilled from existing medication fields
  • usage updated 2026-04-25 10:05 by etl_backfill • Backfilled from existing medication fields
  • side_effects updated 2026-04-22 10:14 by etl_backfill • Backfilled from existing medication fields
  • contraindications updated 2026-04-22 10:14 by etl_backfill • Backfilled from existing medication fields
  • usage updated 2026-04-22 10:14 by etl_backfill • Backfilled from existing medication fields
  • side_effects updated 2026-04-15 10:04 by etl_backfill • Backfilled from existing medication fields
  • side_effects updated 2026-04-11 10:05 by etl_backfill • Backfilled from existing medication fields
  • side_effects updated 2026-02-12 22:44 by etl_backfill • Backfilled from existing medication fields

FDA Products & Applications (Animal Drugs @ FDA)

Official sponsor/proprietary-name/application-status records linked by active ingredient.

Product Sponsor Application Status Published
Sentinel® Spectrum®
RX
Lufenuron Milbemycin Oxime Praziquantel
Chewable Tablets • Oral
Label highlights
Official documents
Intervet, Inc. NADA 141-333 Approved Aug 3, 2020

Data source: FDA Animal Drugs @ FDA (public search export).

What It's For (FDA Label Highlights)

Extracted from FDA Animal Drugs @ FDA product labeling. Always confirm details with your veterinarian.

Species: Dog
Composition / specifications
Each chewable tablet contains: 2.3 mg milbemycin oxime/46 mg lufenuron/22.8 mg praziquantel; 5.75 mg milbemycin oxime/115 mg lufenuron/57 mg praziquantel; 11.5 mg milbemycin oxime/230 mg lufenuron/114 mg praziquantel; 23.0 mg milbemycin oxime/460 mg lufenuron/228 mg praziquantel
Dogs
Indication

For the prevention of heartworm disease caused by Dirofilaria immitis; for the prevention and control of flea populations (Ctenocephalides felis); and for the treatment and control of adult roundworm (Toxocara canis, Toxascaris leonina), adult hookworm (Ancylostoma caninum), adult whipworm (Trichuris vulpis), and adult tapeworm (Dipylidium caninum,Taenia pisiformis, Echinococcus multilocularis and Echinococcus granulosus) infections in dogs and puppies two pounds of body weight or greater and six weeks of age and older.

Dosage

SENTINEL SPECTRUM is given orally, once a month, at the minimum dosage of 0.23 mg/pound body weight (0.5 mg/kg) of milbemycin oxime, 4.55 mg/pound (10 mg/kg) of lufenuron, and 2.28 mg/pound (5 mg/kg) of praziquantel. For heartworm prevention, give once monthly beginning within 1 month of the dog’s first seasonal exposure to mosquitoes and continuing until at least 6 months after the dog’s last seasonal exposure.

Limitations

Federal law restricts this drug to use by or on the order of a licensed veterinarian.

FDA page: Open in Animal Drugs @ FDA

Usage

For the prevention of heartworm disease caused by Dirofilaria immitis ; for the prevention and control of flea populations ( Ctenocephalides felis ); and for the treatment and control of adult roundworm ( Toxocara canis , Toxascaris leonina ), adult hookworm ( Ancylostoma caninum ), adult whipworm ( Trichuris vulpis ), and adult tapeworm ( Dipylidium caninum , Taenia pisiformis , Echinococcus multilocularis and Echinococcus granulosus ) infections in dogs and puppies two pounds of body weight or greater and six weeks of age and older.

Source: FDA Animal Drugs @ FDA • Reference

Contraindications

Federal law restricts this drug to use by or on the order of a licensed veterinarian.

Top Reported Reactions (openFDA)

De-duplicated reaction terms grouped by body system from FDA openFDA reports (not verified; does not prove causation).

Digestive
Vomiting (1) • Cat Drooling (1) • Dog Diarrhea (1) • Dog Bloody diarrhoea (1) • Dog

Showing top 5 for Digestive.

Skin & allergy
Itching (1) • Dog Injection site swelling (1) • Dog Hair loss (1) • Dog Biting - pruritus (1) • Dog

Showing top 5 for Skin & allergy.

Neurologic
Unsteady walking (1) • Dog Increased seizure frequency (1) • Dog Grand mal seizure (1) • Cat

Showing top 5 for Neurologic.

Behavior
Behavioral disorder (1) • Dog

Showing top 5 for Behavior.

Effectiveness
Lack of efficacy (endoparasite) - roundworm NOS (1) • Dog Lack of efficacy (endoparasite) - hookworm (1) • Dog Lack of efficacy (endoparasite) - heartworm (1) • Dog Lack of efficacy (bacteria) - Ehrlichia (1) • Dog Lack of efficacy (bacteria) - Borrelia (1) • Dog
Show more (1)
Lack of efficacy (bacteria) - Anaplasma (1) • Dog

Showing top 5 for Effectiveness.

Other
Hypochloraemia (1) • Dog Hiding (1) • Cat Head shake - ear disorder (1) • Dog Haemorrhagic gastroenteritis (1) • Dog Fracture (1) • Dog
Show more (9)
Fever (1) • Cat Ear infection NOS (1) • Dog Dysphoria (1) • Cat Dilated pupils (1) • Cat Death (1) • Dog Cough (1) • Dog Constipation (1) • Dog Conjunctivitis (1) • Dog Bacterial skin infection NOS (1) • Dog

Showing top 5 for Other.

Data source: FDA openFDA Animal & Veterinary adverse event reports.

Adverse Event Case Summaries (openFDA)

These are individual FDA adverse event reports. They are unverified and do not prove the medication caused the reaction.

No case-level openFDA reports are linked for this medication yet.

Data source: FDA openFDA Animal & Veterinary adverse event reports.

Overdose Information

No approved overdose-management text is linked yet. If overdose is suspected, contact a veterinarian or emergency clinic immediately.

Storage & Handling

No approved storage guidance is linked yet for this ingredient. Use manufacturer packaging and veterinary guidance for handling/storage.

Share Your Thoughts

Let others know your experience or advice regarding this medication.

This medication has not been reviewed by a veterinarian yet.