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Roxee Medication Guide

Pentobarbital, Phenytoin

Medication reference facts with explicit FDA-approval, off-label, source-limited, and safety context. Roxee does not sell, prescribe, or dispense medications.

Both Reference complete FDA data linked Rx required Solution Multiple FDA labelers Official label facts Owner quick guide first
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Showing simplified owner view. Switch to Vet View for full technical detail.

Data freshness

Reference facts
Reference refreshed
Jun 22, 2026, 10:41 a.m.

These are the reference facts Roxee uses on browse cards and quick facts.

FDA applications
FDA application data refreshed
Jun 22, 2026, 10:41 a.m.

Sponsor, product, and application records imported from Animal Drugs @ FDA.

Safety reports
No safety reports linked
No refresh timestamp yet

openFDA reaction terms and case summaries are supporting evidence, not proof of causality.

Source timing details
Source timing details
  • Reference facts: Source Roxee | Refreshed Jun 22, 2026, 10:41 AM UTC
    The reference fact projection used for browse cards and quick facts.
  • Animal Drugs @ FDA: Source FDA | Refreshed Jun 22, 2026, 10:41 AM UTC
    Applications/products are imported from FDA export data.
  • Animal Drugs @ FDA previews: Source FDA | Refreshed Apr 11, 2026, 10:01 AM UTC
    Label highlights/doc links are fetched from FDA preview endpoints.
  • Animal Drug Product Listing Directory (NDC): Source FDA | Refreshed Jun 22, 2026, 10:41 AM UTC
    Package/product NDCs from FDA’s electronic listing directory (XLS).
Image coming soon
Pentobarbital, Phenytoin

Pentobarbital, Phenytoin

Drug type: Generic ingredient • Branded profile • FDA branded products available

Both Solution Rx required 100% reference complete

Species: Both

Manufacturer: Multiple FDA labelers

Medication Snapshot

Merged from the current Roxee medication system with field-level provenance, freshness, and completeness tracking.

Pentobarbital, Phenytoin

For humane, painless, and rapid euthanasia. For the humane, painless, and rapid euthanasia of dogs. For the humane, painless, and rapid euthanasia. Species commonly shown: Both, Dog.

Generic name
Pentobarbital, Phenytoin
Brand names
Euthasol®, Euthanasia-III Solution, Pentobarbital Sodium and Phenytoin Sodium, Beuthanasia-D Special
Manufacturer
Multiple FDA labelers
Species
Both, Dog
Dosage forms
Solution, Liquid (Solution), Injectable Solution
Prescription
Prescription required
Completeness
100%
Validation
Complete
Brand names
Euthasol® Euthanasia-III Solution Pentobarbital Sodium and Phenytoin Sodium Beuthanasia-D Special Euthanasia Solution Euthasol
Dosage forms
Solution Liquid (Solution) Injectable Solution

Indications / Uses

For humane, painless, and rapid euthanasia. For the humane, painless, and rapid euthanasia of dogs. For the humane, painless, and rapid euthanasia.

Warnings / Contraindications

Do not use in animals intended for food. Federal law restricts this drug to use by or on the order of a licensed veterinarian. Do not use for therapeutic purposes. Do not use in animals intended for food. Federal law restricts this drug to use by or on the order of a licensed veterinarian.

  • Do not use in animals intended for food. Federal law restricts this drug to use by or on the order of a licensed veterinarian. Do not use for therapeutic purposes. Do not use in animals intended for food. Federal law restricts this drug to use by or on the order of a licensed veterinarian.

FAQ

Both, Dog

Yes. Roxee shows this as prescription-only.

Solution, Liquid (Solution), Injectable Solution

Related Conditions

Pain (acute, chronic)

Source Transparency

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Pet Owner Quick Guide

Start here first for the safest next-step summary before the deeper medication detail.

Used for:

For humane, painless, and rapid euthanasia.

Dosing note:

Exact dosing depends on your pet's species, weight, and health status. Use your veterinarian's instructions for the exact dose and schedule.

What to watch for:

  • Do not use in animals intended for food
  • Do not use for therapeutic purposes

When to call the vet:

  • Repeated vomiting or diarrhea.
  • Severe lethargy (hard to wake, very low energy).
  • Collapse or fainting.
  • Trouble breathing.
  • Facial swelling or hives.
  • Blood in vomit or stool.

Regulatory restrictions are shown in Vet View.

What to tell or ask your vet today:

  • Is this medicine the right fit for my pet’s current symptoms?
  • Which warning signs mean I should call back right away?
  • How should I handle missed doses or refusal to take the medicine?

Next actions

Talk to a Vet / Find a Vet Near You Save to pet meds Share page Review report evidence
Research brief

Medication Research Insights

A source-aware map of what to know, what is uncertain, and what to verify with your veterinarian.

Source Backed Limited Signals

What to know

Evidence-backed context Limited

Roxee has limited cited overview evidence for Pentobarbital, Phenytoin; use the official documents and your veterinarian's instructions for product-specific decisions.

Source: openFDA adverse-event data
Safety signal coverage No signal rollup

No source-backed adverse-reaction rollup is linked yet. That is a data gap, not proof that no reactions occur.

Source: openFDA adverse-event data
Interpretation guardrail Not causation

Adverse-event reports help form a watch list, but they do not prove the medication caused the reaction and they are not a risk ranking between medications.

Evidence tension

Stronger signal Label / review

Official labels, package inserts, and reviewed summaries carry more weight than isolated reports.

Source: openFDA adverse-event data
Weaker signal Reported data

Case reports and openFDA terms are useful for pattern awareness, but they are incomplete, can include multiple exposures, and do not estimate an individual pet's probability of harm.

Reaction signal map

Reaction signal map Limited data

No source-backed adverse-reaction rollup is linked yet for this medication. Use the owner watch list, official documents, and veterinary guidance.

What your vet may verify

Fit for this patient Vet check

Verify whether Pentobarbital, Phenytoin fits the pet's species, current diagnosis, age, weight, organ status, pregnancy/lactation status, and concurrent medications.

Evidence limitations Evidence review

Separate label-backed warnings from adverse-event reports and owner observations before changing the plan.

What to watch next

Watch list Owner-safe

Do not use in animals intended for food, Do not use for therapeutic purposes

Call sooner if Escalation

Repeated vomiting or diarrhea. Severe lethargy (hard to wake, very low energy). Collapse or fainting.

Bottom line: Roxee has limited reaction-signal depth for Pentobarbital, Phenytoin right now. Use veterinary instructions, official documents, and direct clinic guidance for decisions.
Vet source depth
  1. openFDA adverse-event data · openfda · adverse reactions
  2. Contraindication source · fda_animal_drugs · warnings contraindications
  3. FDA application profile · official_label · quick facts
  4. FDA application profile · official_label · quick facts
  5. Medication usage source · fda_animal_drugs · quick facts
  6. FOI · document · documents
  7. SPL · document · documents
  8. FOI · document · documents

Evidence

Review status / Updated / Sources

Review status: Clinical reviewer not listed

Updated: April 22, 2026, 10:06 AM UTC

Sources:
Safety & side effects

Side effects to monitor:

  • Do not use in animals intended for food
  • Do not use for therapeutic purposes

Emergency warning signs:

  • Repeated vomiting or diarrhea.
  • Severe lethargy (hard to wake, very low energy).
  • Collapse or fainting.
  • Trouble breathing.
Talk to a Vet / Find a Vet Near You Start Symptom Intake

Vet Fast Scan

Source-backed clinical checkpoints for quick review.

FDA-labeled species
Dog
Indication / use
For humane, painless, and rapid euthanasia.
Form / route / dose
Form: Injectable Solution, Liquid (Solution)
Route: Intracardiac, Intravenous
Confirm product label and patient-specific plan.
Warnings
  • High: Do not use in animals intended for food. Federal law restricts this drug to use by or on the order of a licensed veteri…
Adverse-event caveat
No stored openFDA case explorer rows are linked yet.
Source docs

Quick Facts

Official label facts first, then secondary summaries. Marketing content is separated below.

Species: Both
Manufacturer: Multiple FDA labelers
Form: Injectable Solution, Liquid (Solution)
Identifiers:
ANADA: 200071 ANADA: 200280 ANADA: 200614 NADA: 119807 NDC Package: 11695-7042-1 NDC Package: 51311-050-01 NDC Package: 86119-200-05 NDC Package: 86136-138-31 NDC Product: 11695 NDC Product: 51311 NDC Product: 86119 NDC Product: 86136
Source metadata:

Warnings / Contraindications

Do not use in animals intended for food. Federal law restricts this drug to use by or on the order of a licensed veterinarian. Do not use for therapeutic purposes. Do not use in animals intended for food. Federal law restricts this drug to use by or on the order of a licensed veterinarian.

  • High: Do not use in animals intended for food. Federal law restricts this drug to use by or on the order of a licensed veterinarian. Do not use for therapeutic purposes. Do not use in animals intended for food. Federal law restricts this drug to use by or on the order of a licensed veterinarian.
Source metadata:

Source Documents

The most useful source links appear first; full previews and metadata stay in the veterinary/professional layer.

Use original documents to confirm product-specific warnings, ingredients, and handling details with your veterinarian.

Euthanasia-III Solution SPL · SPL Pentobarbital Sodium and Phenytoin Sodium SPL · SPL Euthasol® SPL · SPL

Full source previews and metadata remain in the veterinary/professional layer.

Owner handouts

0
No owner handouts linked yet.

Official label / PI

0
No official label or package insert links yet.

SPL

8

FOI

3

Euthanasia-III Solution

SPL · SPL

Open original
FDA Structured Product Label

Euthanasia-III Solution

Rendered from Roxee's cached FDA SPL package contents for on-page reading. Use Open original for the raw FDA ZIP/XML source.

Sponsor
Dechra Veterinary Products LLC
ANADA
200-280
Status
RX
Form
Liquid (Solution)
Route
Intravenous, Intracardiac
Species
Dog
Composition / specifications
Each milliliter of non-sterile solution contains 390 milligrams of pentobarbital sodium and 50 milligrams of phenytoin sodium.

Dogs

Indication
For humane, painless, and rapid euthanasia.
Dosage
One milliliter (390 milligrams of pentobarbital sodium and 50 milligrams of phenytoin sodium) for each 10 pounds of body weight. For intravenous injection or intracardiac injection when intravenous use is impractical.
Limitations
Do not use in animals intended for food. Federal law restricts this drug to use by or on the order of a licensed veterinarian.

Pentobarbital Sodium and Phenytoin Sodium

SPL · SPL

Open original
FDA Structured Product Label

Pentobarbital Sodium and Phenytoin Sodium

Rendered from Roxee's cached FDA SPL package contents for on-page reading. Use Open original for the raw FDA ZIP/XML source.

Sponsor
Noble Pharma, LLC
ANADA
200-614
Status
RX
Form
Injectable Solution
Route
Intravenous, Intracardiac
Species
Dog
Composition / specifications
390 mg/mL pentobarbital sodium and 50 mg/mL phenytoin sodium

Dogs

Indication

For use in dogs for humane, painless, and rapid euthanasia.

Dosage

1 mL for each 10 pounds of body weight.

Euthasol®

SPL · SPL

Open original
FDA Structured Product Label

Euthasol®

Rendered from Roxee's cached FDA SPL package contents for on-page reading. Use Open original for the raw FDA ZIP/XML source.

Sponsor
Virbac AH, Inc.
ANADA
200-071
Status
RX
Form
Liquid (Solution)
Route
Intracardiac, Intravenous
Species
Dog
Composition / specifications
Each milliliter of non-sterile solution contains 390 milligrams of pentobarbital sodium and 50 milligrams of phenytoin sodium.

Dogs

Indication
For the humane, painless, and rapid euthanasia of dogs.
Dosage
One milliliter for each 10 pounds of body weight.
Limitations
Do not use in animals intended for food. Federal law restricts this drug to use by or on the order of a licensed veterinarian.

Beuthanasia-D Special

SPL · SPL

Open original
FDA Structured Product Label

Beuthanasia-D Special

Rendered from Roxee's cached FDA SPL package contents for on-page reading. Use Open original for the raw FDA ZIP/XML source.

Sponsor
Intervet, Inc.
NADA
119-807
Status
RX
Form
Liquid (Solution)
Route
Intravenous, Intracardiac
Species
Dog
Composition / specifications
Each milliliter of non-sterile solution contains 390 milligrams of pentobarbital sodium and 50 milligrams of phenytoin sodium.

Dogs

Indication
For the humane, painless, and rapid euthanasia.
Dosage
One milliliter (390 milligrams of pentobarbital sodium and 50 milligrams of phenytoin sodium) for each 10 pounds of body weight. For intravenous injection or intracardiac injection when intravenous use is impractical.
Limitations
Do not use for therapeutic purposes. Do not use in animals intended for food. Federal law restricts this drug to use by or on the order of a licensed veterinarian.

Euthanasia Solution SPL

SPL · Structured Product Label

Open original
FDA Structured Product Label XML for Euthanasia Solution. Use the source link for the full official labeling record.

Euthanasia Solution SPL

SPL · Structured Product Label

Open original
FDA Structured Product Label XML for Euthanasia Solution. Use the source link for the full official labeling record.

Euthasol SPL

SPL · Structured Product Label

Open original
FDA Structured Product Label XML for Euthasol. Use the source link for the full official labeling record.

Euthanasia Solution SPL

SPL · Structured Product Label

Open original
FDA Structured Product Label XML for Euthanasia Solution. Use the source link for the full official labeling record.

ucm061706.pdf

FOI · FOI

Open original

FOI Summary oA 200-614 Approved February 7, 2020.pdf

FOI · FOI

Open original

A200071_Org_2_24_1994.pdf

FOI · FOI

Open original
Source metadata:
Veterinary reference (advanced)

Canonical medication sections are above. This legacy block remains available for deeper cross-reference without cluttering the primary workflow.

At a Glance

Quick facts and links to official labeling and safety signals.

Data freshness
  • Reference facts: Source Roxee | Refreshed Jun 22, 2026, 10:41 AM UTC
    The reference fact projection used for browse cards and quick facts.
  • Animal Drugs @ FDA: Source FDA | Refreshed Jun 22, 2026, 10:41 AM UTC
    Applications/products are imported from FDA export data.
  • Animal Drugs @ FDA previews: Source FDA | Refreshed Apr 11, 2026, 10:01 AM UTC
    Label highlights/doc links are fetched from FDA preview endpoints.
  • Animal Drug Product Listing Directory (NDC): Source FDA | Refreshed Jun 22, 2026, 10:41 AM UTC
    Package/product NDCs from FDA’s electronic listing directory (XLS).
Official (FDA)
Identity: Generic ingredient • FDA branded products available
Official FDA brands: Euthanasia Solution Euthasol
Manufacturer mapping: Multiple FDA labelers
Catalog species: Both • FDA-labeled species: Dog
Rx/OTC: RX
Form/route: Injectable Solution, Liquid (Solution) • Intracardiac, Intravenous
Applications: ANADA 200-280 • ANADA 200-614 • ANADA 200-071 • NADA 119-807
NDC: Packages 11695-7042-1 51311-050-01 86119-200-05 86136-138-31 • Products 11695 51311 86119 86136
Documents: 3 (FOI: 3) • SPL: 4 • Label highlights • Official documents
Safety (openFDA)
Top reactions: Dog 0 • Cat 0
Case summaries: 0
openFDA reports are unverified and do not prove causation.
Explore
Related conditions: Pain (acute, chronic)
Linked using: Fda_Label (0.95)
Diagnosis Codes

Diagnosis-code mappings are not available for this medication yet.

Counseling and Monitoring Highlights

Global Pet owner/Vet mode is controlled in the header. This section avoids duplicate in-page persona tabs.

Owner-facing counseling points
  • Do not use in animals intended for food. Federal law restricts this drug to use by or on the order of a licensed veterinarian. Do not use for therapeutic purposes. Do not use in animals intended for food. Federal law restricts this drug to use by or on the order of a licensed veterinarian. (Contraindication, High)

Identifiers & Packages

Normalized identifiers (NDC/NADA/ANADA) and package metadata from regulator listings.

Identifiers
ANADA: 200071 ANADA: 200280 ANADA: 200614 NADA: 119807 NDC Package: 11695-7042-1 NDC Package: 51311-050-01 NDC Package: 86119-200-05 NDC Package: 86136-138-31 NDC Product: 11695 NDC Product: 51311 NDC Product: 86119 NDC Product: 86136
Package NDC Product NDC Form / Route Status
11695-7042-1 11695 -
51311-050-01 51311 -
86119-200-05 86119 -
86136-138-31 86136 -

Enriched Documents

Documents are tiered by source trust: Official, Clinical, Manufacturer, Marketing.

  • Euthanasia Solution SPL • Structured Product Label • Official
    FDA Structured Product Label from the electronic animal drug product listing directory.
  • Euthanasia Solution SPL • Structured Product Label • Official
    FDA Structured Product Label from the electronic animal drug product listing directory.
  • Euthasol SPL • Structured Product Label • Official
    FDA Structured Product Label from the electronic animal drug product listing directory.
  • Euthanasia Solution SPL • Structured Product Label • Official
    FDA Structured Product Label from the electronic animal drug product listing directory.
  • ucm061706.pdf • FOI summary • Official • Feb. 27, 2026
    FDA FOI summary for application 200280
  • FOI Summary oA 200-614 Approved February 7, 2020.pdf • FOI summary • Official • Oct. 25, 2023
    FDA FOI summary for application 200614
  • A200071_Org_2_24_1994.pdf • FOI summary • Official • May 16, 2017
    FDA FOI summary for application 200071

Data Sources & Change Log

Every non-trivial field is expected to include provenance and update timestamps.

Official 127 Clinical 0 Manufacturer 0 Marketing 0
Current Field Facts
  • contraindications: Do not use in animals intended for food. Federal law restricts this drug to use by or on the order of a licensed veterinarian. Do not use for therapeutic purpo… (Official, 2026-04-22)
  • dosage_forms: Solution (Official, 2026-06-22)
  • dosage_forms: Solution (Official, 2026-06-22)
  • dosage_forms: Solution (Official, 2026-06-21)
  • dosage_forms: Solution (Official, 2026-06-20)
  • dosage_forms: Solution (Official, 2026-06-13)
  • dosage_forms: Solution (Official, 2026-06-12)
  • dosage_forms: Solution (Official, 2026-06-12)
  • dosage_forms: Solution (Official, 2026-06-11)
  • dosage_forms: Solution (Official, 2026-06-11)
  • dosage_forms: Solution (Official, 2026-06-10)
  • dosage_forms: Solution (Official, 2026-06-09)
  • dosage_forms: Solution (Official, 2026-06-08)
  • dosage_forms: Solution (Official, 2026-06-07)
  • dosage_forms: Solution (Official, 2026-06-06)
  • dosage_forms: Solution (Official, 2026-06-05)
  • dosage_forms: Solution (Official, 2026-06-04)
  • dosage_forms: Solution (Official, 2026-06-03)
  • dosage_forms: Solution (Official, 2026-06-02)
  • dosage_forms: Solution (Official, 2026-06-01)
Recent Revisions
  • contraindications updated 2026-04-22 10:07 by etl_backfill • Backfilled from existing medication fields
  • usage updated 2026-04-22 10:07 by etl_backfill • Backfilled from existing medication fields

FDA Products & Applications (Animal Drugs @ FDA)

Official sponsor/proprietary-name/application-status records linked by active ingredient.

Product Sponsor Application Status Published
Euthanasia-III Solution
RX
Pentobarbital Sodium Phenytoin Sodium
Liquid (Solution) • Intravenous, Intracardiac
Label highlights
Official documents
Dechra Veterinary Products LLC ANADA 200-280 Approved Feb 27, 2026
Pentobarbital Sodium and Phenytoin Sodium
RX
Pentobarbital Sodium Phenytoin Sodium
Injectable Solution • Intravenous, Intracardiac
Label highlights
Official documents
Noble Pharma, LLC ANADA 200-614 Approved Oct 25, 2023
Euthasol®
RX
Pentobarbital Sodium Phenytoin Sodium
Liquid (Solution) • Intracardiac, Intravenous
Label highlights
Official documents
Virbac AH, Inc. ANADA 200-071 Approved May 16, 2017
Beuthanasia-D Special
RX
Pentobarbital Sodium Phenytoin Sodium
Liquid (Solution) • Intravenous, Intracardiac
Label highlights
Official documents
Intervet, Inc. NADA 119-807 Approved Jun 1, 2016

Data source: FDA Animal Drugs @ FDA (public search export).

What It's For (FDA Label Highlights)

Extracted from FDA Animal Drugs @ FDA product labeling. Always confirm details with your veterinarian.

Species: Dog
Composition / specifications
Each milliliter of non-sterile solution contains 390 milligrams of pentobarbital sodium and 50 milligrams of phenytoin sodium.
Dogs
Indication
For humane, painless, and rapid euthanasia.
Dosage
One milliliter (390 milligrams of pentobarbital sodium and 50 milligrams of phenytoin sodium) for each 10 pounds of body weight. For intravenous injection or intracardiac injection when intravenous use is impractical.
Limitations
Do not use in animals intended for food. Federal law restricts this drug to use by or on the order of a licensed veterinarian.

FDA page: Open in Animal Drugs @ FDA

Species: Dog
Composition / specifications
390 mg/mL pentobarbital sodium and 50 mg/mL phenytoin sodium
Dogs
Indication

For use in dogs for humane, painless, and rapid euthanasia.

Dosage

1 mL for each 10 pounds of body weight.

Limitations

FDA page: Open in Animal Drugs @ FDA

Species: Dog
Composition / specifications
Each milliliter of non-sterile solution contains 390 milligrams of pentobarbital sodium and 50 milligrams of phenytoin sodium.
Dogs
Indication
For the humane, painless, and rapid euthanasia of dogs.
Dosage
One milliliter for each 10 pounds of body weight.
Limitations
Do not use in animals intended for food. Federal law restricts this drug to use by or on the order of a licensed veterinarian.

FDA page: Open in Animal Drugs @ FDA

Species: Dog
Composition / specifications
Each milliliter of non-sterile solution contains 390 milligrams of pentobarbital sodium and 50 milligrams of phenytoin sodium.
Dogs
Indication
For the humane, painless, and rapid euthanasia.
Dosage
One milliliter (390 milligrams of pentobarbital sodium and 50 milligrams of phenytoin sodium) for each 10 pounds of body weight. For intravenous injection or intracardiac injection when intravenous use is impractical.
Limitations
Do not use for therapeutic purposes. Do not use in animals intended for food. Federal law restricts this drug to use by or on the order of a licensed veterinarian.

FDA page: Open in Animal Drugs @ FDA

Usage

For humane, painless, and rapid euthanasia. For the humane, painless, and rapid euthanasia of dogs. For the humane, painless, and rapid euthanasia.

Source: FDA Animal Drugs @ FDA • Reference

Contraindications

Do not use in animals intended for food. Federal law restricts this drug to use by or on the order of a licensed veterinarian. Do not use for therapeutic purposes. Do not use in animals intended for food. Federal law restricts this drug to use by or on the order of a licensed veterinarian.

Adverse Event Case Summaries (openFDA)

These are individual FDA adverse event reports. They are unverified and do not prove the medication caused the reaction.

No case-level openFDA reports are linked for this medication yet.

Data source: FDA openFDA Animal & Veterinary adverse event reports.

Overdose Information

No approved overdose-management text is linked yet. If overdose is suspected, contact a veterinarian or emergency clinic immediately.

Storage & Handling

No approved storage guidance is linked yet for this ingredient. Use manufacturer packaging and veterinary guidance for handling/storage.

Share Your Thoughts

Let others know your experience or advice regarding this medication.

This medication has not been reviewed by a veterinarian yet.