Roxee Meds Catalog

Pergolide Mesylate

Medication catalog facts with explicit FDA-approval, off-label, source-limited, and safety context.

Both Catalog complete FDA data linked Rx required Tablet Multiple FDA labelers Official label facts Owner quick guide first

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FDA applications

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Sponsor, product, and application records imported from Animal Drugs @ FDA.

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Source timing details

Storefront facts: Source Roxee | Refreshed May 5, 2026, 10:00 AM UTC
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Animal Drugs @ FDA: Source FDA | Refreshed May 5, 2026, 10:00 AM UTC
Applications/products are imported from FDA export data.
Animal Drugs @ FDA previews: Source FDA | Refreshed Feb 9, 2026, 3:05 AM UTC
Label highlights/doc links are fetched from FDA preview endpoints.
Animal Drug Product Listing Directory (NDC): Source FDA | Refreshed May 5, 2026, 10:00 AM UTC
Package/product NDCs from FDA’s electronic listing directory (XLS).

Evidence

Reviewed / Updated / Sources

Reviewed by: Not available

Last reviewed: February 12, 2026

Updated: February 12, 2026, 10:44 PM UTC

Sources:

FDA application profile · official_label
FDA application profile · official_label
Medication usage source · fda_animal_drugs
openFDA case USA-USFDACVM-2025-US-020401 · adverse_reaction
FOI · document

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Pergolide Mesylate

Drug type: Generic ingredient • Branded profile • FDA branded products available

Both Tablet Rx required 100% storefront ready

Species: Both

Manufacturer: Multiple FDA labelers

Medication Snapshot

Merged from the current Roxee medication system with field-level provenance, freshness, and completeness tracking.

Pergolide Mesylate

For the control of clinical signs associated with Pituitary Pars Intermedia Dysfunction (Equine Cushing's Disease) in horses. For the control of clinical signs associated with Pituitary Pars Intermedia Dysfunction (Equine Cushing’s Disease) in horses. Species commonly shown: Both, No Use Class Stated Or Implied.

Generic name

Pergolide Mesylate

Brand names

Prascend®, Zygolide®, Zygolide, Pergolide Mesylate

Manufacturer

Multiple FDA labelers

Species

Both, No Use Class Stated Or Implied

Dosage forms

Tablet

Prescription

Prescription required

Completeness

100%

Validation

Complete

Brand names

Prascend® Zygolide® Zygolide Pergolide Mesylate Prascend

Dosage forms

Tablet

Indications / Uses

Warnings / Contraindications

Federal law restricts this drug to use by or on the order of a licensed veterinarian. For oral use in horses only. The use of Prascend in breeding, pregnant, or lactating horses has not been evaluated. The effects of pergolide mesylate on breeding, pregnant, or lactating horses are not known; however, the pharmacologic action of pergolide mesylate suggests that it may interfere with reproductive functions such as lactation.

Federal law restricts this drug to use by or on the order of a licensed veterinarian. For oral use in horses only. The use of Prascend in breeding, pregnant, or lactating horses has not been evaluated. The effects of pergolide mesylate on breeding, pregnant, or lactating horses are not known; however, the pharmacologic action of pergolide mesylate suggests that it may interfere with reproductive functions such as lactation.

Side Effects

Top reported reactions (openFDA): Accidental exposure, Emesis, Vomiting, Emesis (multiple), Lethargy (see also Central nervous system depression in 'Neurological'), Shaking.

FAQ

Both, No Use Class Stated Or Implied

Yes. Roxee shows this as prescription-only.

Tablet

Related Conditions

Cushing’s Disease (Hyperadrenocorticism) Cushing’s Disease (Hyperadrenocorticism)

Source Transparency

Verified source: https://www.roxee.ai/meds/
Verified source: https://animaldrugsatfda.fda.gov
Verified source: https://animaldrugsatfda.fda.gov/adafda/views/#/search
Verified source: https://api.fda.gov/animalandveterinary/event.json
Verified source: https://www.roxee.ai/conditions/
Verified source: https://www.accessdata.fda.gov/spl/data/f366148e-5b72-4853-b867-b403dd649eaf/f366148e-5b72-4853-b867-b403dd649eaf.xml
Last refreshed: May 5, 2026, 10:00 a.m.
Last verified: Feb 12, 2026, 10:44 p.m.
Validation status: Complete

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Pet Owner Quick Guide

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Used for:

For the control of clinical signs associated with Pituitary Pars Intermedia Dysfunction (Equine Cushing’s Disease) in horses.

Dosing note:

Exact dosing depends on your pet's species, weight, and health status. Use your veterinarian's instructions for the exact dose and schedule.

What to watch for:

For oral use in horses only
The use of Prascend in breeding, pregnant, or lactating horses has not been evaluated
The effects of pergolide mesylate on breeding, pregnant, or lactating horses are not known
however, the pharmacologic action of pergolide mesylate suggests that it may interfere with reproductive functions such as lactation
Vomiting bile (1 reports)
Vomiting (1 reports)
very low energy (1 reports)

When to call the vet:

Repeated vomiting or diarrhea.
Severe lethargy (hard to wake, very low energy).
Collapse or fainting.
Trouble breathing.
Facial swelling or hives.
Blood in vomit or stool.

Regulatory restrictions are shown in Vet View.

What to tell or ask your vet today:

Is this medicine the right fit for my pet’s current symptoms?
Which warning signs mean I should call back right away?
How should I handle missed doses or refusal to take the medicine?

Major cautions & emergency warning signs

Side effects to monitor:

For oral use in horses only
The use of Prascend in breeding, pregnant, or lactating horses has not been evaluated
The effects of pergolide mesylate on breeding, pregnant, or lactating horses are not known
however, the pharmacologic action of pergolide mesylate suggests that it may interfere with reproductive functions such as lactation
Vomiting bile

Most reported reactions:

Vomiting bile (1 reports)
Vomiting (1 reports)
Tiredness (lethargy) (1 reports)

Emergency warning signs:

Repeated vomiting or diarrhea.
Severe lethargy (hard to wake, very low energy).
Collapse or fainting.
Trouble breathing.

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Quick Facts

Official label facts first, then secondary summaries. Marketing content is separated below.

Species: Both

Manufacturer: Multiple FDA labelers

Form: Tablet

Identifiers:

ANADA: 200823 NADA: 141331 NDC Package: 0010-4489-01 NDC Package: 0010-4489-02 NDC Package: 17033-907-06 NDC Package: 17033-907-16 NDC Package: 58597-8072-1 NDC Package: 58597-8072-2 NDC Package: 58597-8072-4 NDC Package: 58597-8072-6 NDC Package: 62991-2528-1 NDC Package: 62991-2528-2 NDC Package: 62991-2528-3 NDC Package: 62991-2528-5 NDC Package: 62991-2528-6 NDC Package: 62991-2528-7 NDC Package: 62991-2528-8 NDC Package: 73377-297-01 NDC Package: 73377-297-02 NDC Package: 73377-297-03

Source metadata:

https://animaldrugsatfda.fda.gov/adafda/views/#/home/previewsearch/200823 · official_label · FDA application profile
https://animaldrugsatfda.fda.gov/adafda/views/#/home/previewsearch/141331 · official_label · FDA application profile
https://animaldrugsatfda.fda.gov · fda_animal_drugs · Medication usage source

Warnings / Contraindications

High: Federal law restricts this drug to use by or on the order of a licensed veterinarian. For oral use in horses only. The use of Prascend in breeding, pregnant, or lactating horses has not been evaluated. The effects of pergolide mesylate on breeding, pregnant, or lactating horses are not known; however, the pharmacologic action of pergolide mesylate suggests that it may interfere with reproductive functions such as lactation.

Source metadata:

https://animaldrugsatfda.fda.gov · fda_animal_drugs · Contraindication source

Adverse Reactions

Snapshot first, detailed rows second. This section summarizes signal data and is not a diagnosis.

Tap or hover a reaction to see what it means in plain language.

Tracked signals

Reported cases

Serious reports

Species represented

Grouped by Body System

Digestive (4) · Vomiting bile, Vomiting, Nausea Neurologic (2) · Tiredness (lethargy), Lethargy (see also Central nervous system depression in 'Neurological') Behavior (1) · Anxiety Other (14) · Third eyelid protrusion, Third eyelid extrusion, Tachypnoea

Most Reported Reactions

Body system	Cases	Species
Digestive	1	Dog
Digestive	1	Dog
Neurologic	1	Dog
Other	1	Cat
Other	1	Cat
Other	1	Dog
Other	1	Dog
Other	1	Dog

Species coverage: Dog (14) Cat (7)

View detailed reaction table

Body system	Species	Seriousness	Frequency	Reports
Digestive	Dog	Non-serious	-	1
Digestive	Dog	Non-serious	-	1
Neurologic	Dog	Non-serious	-	1
Other	Cat	Non-serious	-	1
Other	Cat	Non-serious	-	1
Other	Dog	Non-serious	-	1
Other	Dog	Non-serious	-	1
Other	Dog	Non-serious	-	1
Digestive	Dog	Non-serious	-	1
Other	Cat	Non-serious	-	1
Other	Cat	Non-serious	-	1
Other	Cat	Non-serious	-	1
Other	Dog	Non-serious	-	1
Other	Cat	Non-serious	-	1
Digestive	Dog	Non-serious	-	1
Other	Dog	Non-serious	-	1
Behavior	Cat	Non-serious	-	1
Other	Dog	Non-serious	-	1
Other	Dog	Non-serious	-	1
Neurologic	Dog	Unknown	-	-
Other	Dog	Unknown	-	-

Source metadata:

https://api.fda.gov/animalandveterinary/event.json · adverse_reaction · openFDA case USA-USFDACVM-2025-US-020401

Documents

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Owner handouts

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Official label / PI

No official label or package insert links yet.

SPL

FOI

Zygolide®

SPL · SPL

Open original

FDA Structured Product Label

Zygolide®

Rendered from Roxee's cached FDA SPL package contents for on-page reading. Use Open original for the raw FDA ZIP/XML source.

Sponsor: Dechra Veterinary Products LLC
ANADA: 200-823
Status: RX
Form: Tablet
Route: Oral

Composition / specifications

1 mg of pergolide (as pergolide mesylate) per tablet

Horses

Indication

For the control of clinical signs associated with Pituitary Pars Intermedia Dysfunction (Equine Cushing’s Disease) in horses.

Dosage

Administer orally at a starting dose of 2 mcg/kg once daily. Dosage may be adjusted to effect, not to exceed 4 mcg/kg daily.

Prascend®

SPL · SPL

Open original

FDA Structured Product Label

Prascend®

Rendered from Roxee's cached FDA SPL package contents for on-page reading. Use Open original for the raw FDA ZIP/XML source.

Sponsor: Boehringer Ingelheim Animal Health USA, Inc.
NADA: 141-331
Status: RX
Form: Tablet
Route: Oral
Species: No Use Class Stated Or Implied

Composition / specifications

Each tablet contains 1 milligram (mg) pergolide, as pergolide mesylate.

Horses

Indication

For the control of clinical signs associated with Pituitary Pars Intermedia Dysfunction (Equine Cushing's Disease) in horses.

Dosage

Administer orally at a starting dose of 2 mcg/kg once daily. Dosage may be adjusted to effect, not to exceed 4 mcg/kg daily.

Limitations