Roxee Medication Guide

Pergolide Mesylate

Medication reference facts with explicit FDA-approval, off-label, source-limited, and safety context. Roxee does not sell, prescribe, or dispense medications.

Both Reference complete FDA data linked Rx required Tablet Multiple FDA labelers Official label facts Owner quick guide first

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Reference facts

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These are the reference facts Roxee uses on browse cards and quick facts.

FDA applications

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Sponsor, product, and application records imported from Animal Drugs @ FDA.

Safety reports

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openFDA reaction terms and case summaries are supporting evidence, not proof of causality.

Source timing details

Reference facts: Source Roxee | Refreshed Jun 22, 2026, 10:41 AM UTC
The reference fact projection used for browse cards and quick facts.
Animal Drugs @ FDA: Source FDA | Refreshed Jun 22, 2026, 10:41 AM UTC
Applications/products are imported from FDA export data.
Animal Drugs @ FDA previews: Source FDA | Refreshed Feb 9, 2026, 3:05 AM UTC
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Animal Drug Product Listing Directory (NDC): Source FDA | Refreshed Jun 22, 2026, 10:41 AM UTC
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Pergolide Mesylate

Drug type: Generic ingredient • Branded profile • FDA branded products available

Both Tablet Rx required 100% reference complete

Species: Both

Manufacturer: Multiple FDA labelers

Medication Snapshot

Merged from the current Roxee medication system with field-level provenance, freshness, and completeness tracking.

Pergolide Mesylate

For the control of clinical signs associated with Pituitary Pars Intermedia Dysfunction (Equine Cushing's Disease) in horses. For the control of clinical signs associated with Pituitary Pars Intermedia Dysfunction (Equine Cushing’s Disease) in horses. Species commonly shown: Both.

Generic name

Pergolide Mesylate

Brand names

Prascend®, Zygolide®, Pergolide Mesylate, Prascend

Manufacturer

Multiple FDA labelers

Species

Both

Dosage forms

Tablet

Prescription

Prescription required

Completeness

100%

Validation

Complete

Brand names

Prascend® Zygolide® Pergolide Mesylate Prascend Zygolide

Dosage forms

Tablet

Indications / Uses

Warnings / Contraindications

Federal law restricts this drug to use by or on the order of a licensed veterinarian. For oral use in horses only. The use of Prascend in breeding, pregnant, or lactating horses has not been evaluated. The effects of pergolide mesylate on breeding, pregnant, or lactating horses are not known; however, the pharmacologic action of pergolide mesylate suggests that it may interfere with reproductive functions such as lactation.

Federal law restricts this drug to use by or on the order of a licensed veterinarian. For oral use in horses only. The use of Prascend in breeding, pregnant, or lactating horses has not been evaluated. The effects of pergolide mesylate on breeding, pregnant, or lactating horses are not known; however, the pharmacologic action of pergolide mesylate suggests that it may interfere with reproductive functions such as lactation.

Side Effects

Top reported reactions (openFDA): Accidental exposure, Emesis, Vomiting, Emesis (multiple), Lethargy (see also Central nervous system depression in 'Neurological'), Shaking.

FAQ

Both

Yes. Roxee shows this as prescription-only.

Tablet

Related Conditions

Cushing’s Disease (Hyperadrenocorticism) Cushing’s Disease (Hyperadrenocorticism)

Source Transparency

Verified source: https://www.roxee.ai/meds/
Verified source: https://animaldrugsatfda.fda.gov
Verified source: https://animaldrugsatfda.fda.gov/adafda/views/#/search
Verified source: https://api.fda.gov/animalandveterinary/event.json
Verified source: https://www.roxee.ai/conditions/
Verified source: https://www.accessdata.fda.gov/spl/data/b13a0908-82fc-482f-9dd9-c48267444e2a/b13a0908-82fc-482f-9dd9-c48267444e2a.xml
Last refreshed: Jun 22, 2026, 10:41 a.m.
Last verified: Feb 12, 2026, 10:44 p.m.
Validation status: Complete

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Pet Owner Quick Guide

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Used for:

For the control of clinical signs associated with Pituitary Pars Intermedia Dysfunction (Equine Cushing’s Disease) in horses.

Dosing note:

Exact dosing depends on your pet's species, weight, and health status. Use your veterinarian's instructions for the exact dose and schedule.

What to watch for:

For oral use in horses only
The use of Prascend in breeding, pregnant, or lactating horses has not been evaluated
The effects of pergolide mesylate on breeding, pregnant, or lactating horses are not known
however, the pharmacologic action of pergolide mesylate suggests that it may interfere with reproductive functions such as lactation
Vomiting bile (1 reports)
Vomiting (1 reports)
very low energy (1 reports)

When to call the vet:

Repeated vomiting or diarrhea.
Severe lethargy (hard to wake, very low energy).
Collapse or fainting.
Trouble breathing.
Facial swelling or hives.
Blood in vomit or stool.

Regulatory restrictions are shown in Vet View.

What to tell or ask your vet today:

Is this medicine the right fit for my pet’s current symptoms?
Which warning signs mean I should call back right away?
How should I handle missed doses or refusal to take the medicine?

Next actions

Talk to a Vet / Find a Vet Near You Save to pet meds Share page Review report evidence

Research brief

Medication Research Insights

A source-aware map of what to know, what is uncertain, and what to verify with your veterinarian.

Source Backed Signals

What to know

Evidence-backed context Limited

Roxee has limited cited overview evidence for Pergolide Mesylate; use the official documents and your veterinarian's instructions for product-specific decisions.

Source: openFDA case USA-USFDACVM-2025-US-020401

Safety signal coverage Reported signals

21 tracked reaction signals; 19 reported cases; 2 species groups. These are reporting and label-derived signals for interpretation with a veterinarian.

Source: openFDA case USA-USFDACVM-2025-US-020401

Interpretation guardrail Not causation

Adverse-event reports help form a watch list, but they do not prove the medication caused the reaction and they are not a risk ranking between medications.

Evidence tension

Stronger signal Label / review

Official labels, package inserts, and reviewed summaries carry more weight than isolated reports.

Source: openFDA case USA-USFDACVM-2025-US-020401

Weaker signal Reported data

Case reports and openFDA terms are useful for pattern awareness, but they are incomplete, can include multiple exposures, and do not estimate an individual pet's probability of harm.

Reaction signal map

Most reported reactions Top terms

Vomiting bile (1 reports), Vomiting (1 reports), Tiredness (lethargy) (1 reports), Third eyelid protrusion (1 reports), Third eyelid extrusion (1 reports)

Body systems represented Signal grouping

Digestive (4), Neurologic (2), Behavior (1), Other (14)

Species and breed lens

Species represented in reports Species lens

Dog (14 reports), Cat (7 reports)

What your vet may verify

Fit for this patient Vet check

Verify whether Pergolide Mesylate fits the pet's species, current diagnosis, age, weight, organ status, pregnancy/lactation status, and concurrent medications.

Evidence limitations Evidence review

Separate label-backed warnings from adverse-event reports and owner observations before changing the plan.

What to watch next

Watch list Owner-safe

For oral use in horses only, The use of Prascend in breeding, pregnant, or lactating horses has not been evaluated, The effects of pergolide mesylate on breeding, pregnant, or lactating horses are not known, however, the pharmacologic action of pergolide mesylate suggests that it may interfere with reproduc, Vomiting bile

Call sooner if Escalation

Repeated vomiting or diarrhea. Severe lethargy (hard to wake, very low energy). Collapse or fainting.

Bottom line: Use this Pergolide Mesylate brief as a structured watch list and source map, not as a reason to start, stop, or change treatment without your veterinarian.

Vet source depth

openFDA case USA-USFDACVM-2025-US-020401 · adverse_reaction · adverse reactions
Contraindication source · fda_animal_drugs · warnings contraindications
FDA application profile · official_label · quick facts
FDA application profile · official_label · quick facts
Medication usage source · fda_animal_drugs · quick facts
FOI · document · documents
SPL · document · documents
FOI · document · documents

Evidence

Review status / Updated / Sources

Review status: Clinical reviewer not listed

Updated: February 12, 2026, 10:44 PM UTC

Sources:

FDA application profile · official_label
FDA application profile · official_label
Medication usage source · fda_animal_drugs
openFDA case USA-USFDACVM-2025-US-020401 · adverse_reaction
FOI · document

Safety & side effects

Side effects to monitor:

For oral use in horses only
The use of Prascend in breeding, pregnant, or lactating horses has not been evaluated
The effects of pergolide mesylate on breeding, pregnant, or lactating horses are not known
however, the pharmacologic action of pergolide mesylate suggests that it may interfere with reproductive functions such as lactation
Vomiting bile

Most reported reactions:

Vomiting bile (1 reports)
Vomiting (1 reports)
Tiredness (lethargy) (1 reports)

Emergency warning signs:

Repeated vomiting or diarrhea.
Severe lethargy (hard to wake, very low energy).
Collapse or fainting.
Trouble breathing.

Talk to a Vet / Find a Vet Near You Start Symptom Intake

Vet Fast Scan

Source-backed clinical checkpoints for quick review.

FDA-labeled species

Not linked yet

Indication / use

For the control of clinical signs associated with Pituitary Pars Intermedia Dysfunction (Equine Cushing’s Disease) in horses.

Form / route / dose

Form: Tablet
Route: Oral
Confirm product label and patient-specific plan.

Warnings

High: Federal law restricts this drug to use by or on the order of a licensed veterinarian. For oral use in horses only. The …

Adverse-event caveat

No stored openFDA case explorer rows are linked yet.

Source docs

Quick Facts

Official label facts first, then secondary summaries. Marketing content is separated below.

Species: Both

Manufacturer: Multiple FDA labelers

Form: Tablet

Identifiers:

ANADA: 200823 NADA: 141331 NDC Package: 0010-4489-01 NDC Package: 0010-4489-02 NDC Package: 17033-907-06 NDC Package: 17033-907-16 NDC Package: 58597-8072-1 NDC Package: 58597-8072-2 NDC Package: 58597-8072-4 NDC Package: 58597-8072-6 NDC Package: 62991-2528-1 NDC Package: 62991-2528-2 NDC Package: 62991-2528-3 NDC Package: 62991-2528-5 NDC Package: 62991-2528-6 NDC Package: 62991-2528-7 NDC Package: 62991-2528-8 NDC Package: 73377-297-01 NDC Package: 73377-297-02 NDC Package: 73377-297-03

Source metadata:

https://animaldrugsatfda.fda.gov/adafda/views/#/home/previewsearch/200823 · official_label · FDA application profile
https://animaldrugsatfda.fda.gov/adafda/views/#/home/previewsearch/141331 · official_label · FDA application profile
https://animaldrugsatfda.fda.gov · fda_animal_drugs · Medication usage source

Warnings / Contraindications

High: Federal law restricts this drug to use by or on the order of a licensed veterinarian. For oral use in horses only. The use of Prascend in breeding, pregnant, or lactating horses has not been evaluated. The effects of pergolide mesylate on breeding, pregnant, or lactating horses are not known; however, the pharmacologic action of pergolide mesylate suggests that it may interfere with reproductive functions such as lactation.

Source metadata:

https://animaldrugsatfda.fda.gov · fda_animal_drugs · Contraindication source

Adverse Reactions

Snapshot first, detailed rows second. This section summarizes signal data and is not a diagnosis.

Tap or hover a reaction to see what it means in plain language.

Tracked signals

Reported cases

Serious reports

Species represented

Grouped by Body System

Digestive (4) · Vomiting bile, Vomiting, Nausea Neurologic (2) · Tiredness (lethargy), Lethargy (see also Central nervous system depression in 'Neurological') Behavior (1) · Anxiety Other (14) · Third eyelid protrusion, Third eyelid extrusion, Tachypnoea

Most Reported Reactions

Body system	Cases	Species
Digestive	1	Dog
Digestive	1	Dog
Neurologic	1	Dog
Other	1	Cat
Other	1	Cat
Other	1	Dog
Other	1	Dog
Other	1	Dog

Species coverage: Dog (14) Cat (7)

View detailed reaction table

Body system	Species	Seriousness	Frequency	Reports
Digestive	Dog	Non-serious	-	1
Digestive	Dog	Non-serious	-	1
Neurologic	Dog	Non-serious	-	1
Other	Cat	Non-serious	-	1
Other	Cat	Non-serious	-	1
Other	Dog	Non-serious	-	1
Other	Dog	Non-serious	-	1
Other	Dog	Non-serious	-	1
Digestive	Dog	Non-serious	-	1
Other	Cat	Non-serious	-	1
Other	Cat	Non-serious	-	1
Other	Cat	Non-serious	-	1
Other	Dog	Non-serious	-	1
Other	Cat	Non-serious	-	1
Digestive	Dog	Non-serious	-	1
Other	Dog	Non-serious	-	1
Behavior	Cat	Non-serious	-	1
Other	Dog	Non-serious	-	1
Other	Dog	Non-serious	-	1
Neurologic	Dog	Unknown	-	-
Other	Dog	Unknown	-	-

Source metadata:

https://api.fda.gov/animalandveterinary/event.json · adverse_reaction · openFDA case USA-USFDACVM-2025-US-020401

Source Documents

The most useful source links appear first; full previews and metadata stay in the veterinary/professional layer.

Use original documents to confirm product-specific warnings, ingredients, and handling details with your veterinarian.

Zygolide® SPL · SPL Prascend® SPL · SPL Pergolide Mesylate SPL SPL · Structured Product Label

Full source previews and metadata remain in the veterinary/professional layer.

Owner handouts

No owner handouts linked yet.

Official label / PI

No official label or package insert links yet.

SPL

FOI

Zygolide®

SPL · SPL

Open original

FDA Structured Product Label

Zygolide®

Rendered from Roxee's cached FDA SPL package contents for on-page reading. Use Open original for the raw FDA ZIP/XML source.

Sponsor: Dechra Veterinary Products LLC
ANADA: 200-823
Status: RX
Form: Tablet
Route: Oral

Composition / specifications

1 mg of pergolide (as pergolide mesylate) per tablet

Horses

Indication

For the control of clinical signs associated with Pituitary Pars Intermedia Dysfunction (Equine Cushing’s Disease) in horses.

Dosage

Administer orally at a starting dose of 2 mcg/kg once daily. Dosage may be adjusted to effect, not to exceed 4 mcg/kg daily.

Prascend®

SPL · SPL

Open original

FDA Structured Product Label

Prascend®

Rendered from Roxee's cached FDA SPL package contents for on-page reading. Use Open original for the raw FDA ZIP/XML source.

Sponsor: Boehringer Ingelheim Animal Health USA, Inc.
NADA: 141-331
Status: RX
Form: Tablet
Route: Oral

Composition / specifications

Each tablet contains 1 milligram (mg) pergolide, as pergolide mesylate.

Horses

Indication

For the control of clinical signs associated with Pituitary Pars Intermedia Dysfunction (Equine Cushing's Disease) in horses.

Dosage

Administer orally at a starting dose of 2 mcg/kg once daily. Dosage may be adjusted to effect, not to exceed 4 mcg/kg daily.

Limitations