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Roxee Meds Catalog

Phenylpropanolamine Hydrochloride

Medication catalog facts with explicit FDA-approval, off-label, source-limited, and safety context.

Both Catalog complete FDA data linked Rx required Scored Chewable Tablets Multiple FDA sponsors Official label facts Owner quick guide first
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Data freshness

Storefront facts
Catalog refreshed
May 5, 2026, 10:00 a.m.

These are the storefront facts Roxee uses on browse cards and quick facts.

FDA applications
FDA application data refreshed
May 5, 2026, 10:00 a.m.

Sponsor, product, and application records imported from Animal Drugs @ FDA.

Safety reports
Safety data refreshed
May 5, 2026, 10:01 a.m.

openFDA reaction terms and case summaries are supporting evidence, not proof of causality.

Source timing details
Source timing details
  • Storefront facts: Source Roxee | Refreshed May 5, 2026, 10:00 AM UTC
    The storefront fact projection used for browse cards and quick facts.
  • Animal Drugs @ FDA: Source FDA | Refreshed May 5, 2026, 10:00 AM UTC
    Applications/products are imported from FDA export data.
  • Animal Drugs @ FDA previews: Source FDA | Refreshed Feb 9, 2026, 3:05 AM UTC
    Label highlights/doc links are fetched from FDA preview endpoints.
  • openFDA reaction terms: Source FDA openFDA | Refreshed May 5, 2026, 10:04 AM UTC
  • openFDA case summaries: Source FDA openFDA | Refreshed May 5, 2026, 10:04 AM UTC

Evidence

Reviewed / Updated / Sources

Reviewed by: Not available

Last reviewed: February 12, 2026

Updated: February 12, 2026, 10:44 PM UTC

Sources:
Image coming soon
Phenylpropanolamine Hydrochloride

Phenylpropanolamine Hydrochloride

Drug type: Generic ingredient • Generic profile • No FDA branded products linked

Both Scored Chewable Tablets Rx required 100% storefront ready

Species: Both

Manufacturer: Multiple FDA sponsors

Medication Snapshot

Merged from the current Roxee medication system with field-level provenance, freshness, and completeness tracking.

Phenylpropanolamine Hydrochloride

For the control of urinary incontinence due to urethral sphincter hypotonus in dogs. Species commonly shown: Both, Dog, No Use Class Stated Or Implied.

Generic name
Phenylpropanolamine Hydrochloride
Brand names
PROIN® Chewable Tablets, PROIN ER™, Phenylpropanolamine Hydrochloride
Manufacturer
Multiple FDA sponsors
Species
Both, Dog, No Use Class Stated Or Implied
Dosage forms
Scored Chewable Tablets, Tablet, Chewable Tablets
Prescription
Prescription required
Completeness
100%
Validation
Complete
Brand names
PROIN® Chewable Tablets PROIN ER™ Phenylpropanolamine Hydrochloride
Dosage forms
Scored Chewable Tablets Tablet Chewable Tablets

Indications / Uses

For the control of urinary incontinence due to urethral sphincter hypotonus in dogs.

Warnings / Contraindications

Federal law restricts this drug to use by or on the order of a licensed veterinarian.For oral use in dogs only.

  • Federal law restricts this drug to use by or on the order of a licensed veterinarian.For oral use in dogs only.

Side Effects

Top reported reactions (openFDA): Lack of efficacy - NOS, Vomiting, Panting, Diarrhoea, Lethargy (see also Central nervous system depression in 'Neurological'), Emesis (multiple).

FAQ

Both, Dog, No Use Class Stated Or Implied

Yes. Roxee shows this as prescription-only.

Scored Chewable Tablets, Tablet, Chewable Tablets

Related Conditions

Urinary incontinence (spay incontinence, neurogenic)

Source Transparency

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Pet Owner Quick Guide

Start here first for the safest next-step summary before the deeper medication detail.

Used for:

For the control of urinary incontinence due to urethral sphincter hypotonus in dogs.

Dosing note:

Exact dosing depends on your pet's species, weight, and health status. Use your veterinarian's instructions for the exact dose and schedule.

What to watch for:

  • Vomiting (1 reports)
  • wobbly/unsteady walking (1 reports)
  • very low energy (1 reports)

When to call the vet:

  • Repeated vomiting or diarrhea.
  • Severe lethargy (hard to wake, very low energy).
  • Collapse or fainting.
  • Trouble breathing.
  • Facial swelling or hives.
  • Blood in vomit or stool.

Regulatory restrictions are shown in Vet View.

What to tell or ask your vet today:

  • Is this medicine the right fit for my pet’s current symptoms?
  • Which warning signs mean I should call back right away?
  • How should I handle missed doses or refusal to take the medicine?
Major cautions & emergency warning signs

Side effects to monitor:

  • Vomiting
  • wobbly/unsteady walking
  • very low energy

Most reported reactions:

  • Vomiting (1 reports)
  • Unsteady walking (ataxia) (1 reports)
  • Tiredness (lethargy) (1 reports)

Emergency warning signs:

  • Repeated vomiting or diarrhea.
  • Severe lethargy (hard to wake, very low energy).
  • Collapse or fainting.
  • Trouble breathing.
Talk to a Vet / Find a Vet Near You Start Symptom Intake

Quick Facts

Official label facts first, then secondary summaries. Marketing content is separated below.

Species: Both
Manufacturer: Multiple FDA sponsors
Form: Chewable Tablets, Scored Chewable Tablets, Tablet
Identifiers:
ANADA: 200787 NADA: 141324 NADA: 141517 NDC Package: 49427-141-48 NDC Package: 49427-141-50 NDC Package: 49427-315-48 NDC Package: 49427-315-50 NDC Package: 49427-316-48 NDC Package: 49427-316-50 NDC Package: 49427-344-44 NDC Package: 49427-344-57 NDC Package: 49427-345-44 NDC Package: 49427-345-57 NDC Package: 49427-346-44 NDC Package: 49427-346-57 NDC Package: 49427-347-44 NDC Package: 49427-347-57 NDC Package: 86117-042-05 NDC Package: 86117-042-09 NDC Package: 86117-043-05
Source metadata:

Warnings / Contraindications

Federal law restricts this drug to use by or on the order of a licensed veterinarian.For oral use in dogs only.

  • High: Federal law restricts this drug to use by or on the order of a licensed veterinarian.For oral use in dogs only.
Source metadata:

Adverse Reactions

Snapshot first, detailed rows second. This section summarizes signal data and is not a diagnosis.

Tap or hover a reaction to see what it means in plain language.

Tracked signals
32
Reported cases
32
Serious reports
28
Species represented
1
Grouped by Body System
Digestive (2) · Vomiting, Diarrhea Neurologic (3) · Unsteady walking (ataxia), Tiredness (lethargy), Grand mal seizure Behavior (3) · Biting -aggression, Behavioral disorder (unspecified), Anxiety Effectiveness (1) · Lack of efficacy - NOS Other (23) · Lying down, Low creatinine, Limb non-weight bearing
Most Reported Reactions
Reaction Body system Cases Species Serious cases
Digestive 1 Dog 1
Neurologic 1 Dog 1
Neurologic 1 Dog 1
Other 1 Dog 1
Other 1 Dog 1
Other 1 Dog 1
Other 1 Dog 1
Other 1 Dog 1

Species coverage: Dog (32)

View detailed reaction table
Reaction Body system Species Seriousness Frequency Reports
Digestive Dog Serious - 1
Neurologic Dog Serious - 1
Neurologic Dog Serious - 1
Other Dog Non-serious - 1
Other Dog Serious - 1
Other Dog Serious - 1
Effectiveness Dog Non-serious - 1
Other Dog Serious - 1
Other Dog Serious - 1
Other Dog Serious - 1
Other Dog Non-serious - 1
Other Dog Serious - 1
Neurologic Dog Serious - 1
Other Dog Serious - 1
Other Dog Serious - 1
Other Dog Serious - 1
Other Dog Serious - 1
Other Dog Serious - 1
Other Dog Serious - 1
Other Dog Serious - 1
Other Dog Serious - 1
Other Dog Serious - 1
Other Dog Non-serious - 1
Digestive Dog Serious - 1
Other Dog Serious - 1
Other Dog Serious - 1
Other Dog Serious - 1
Behavior Dog Serious - 1
Behavior Dog Serious - 1
Behavior Dog Serious - 1
Other Dog Serious - 1
Other Dog Serious - 1
Source metadata:

Documents

Owner handouts and official technical documents open on-page first, with the original source still one click away.

Owner handouts

0
No owner handouts linked yet.

Official label / PI

0
No official label or package insert links yet.

SPL

3

FOI

3

Phenylpropanolamine Hydrochloride

SPL · SPL

Open original
FDA Structured Product Label

Phenylpropanolamine Hydrochloride

Rendered from Roxee's cached FDA SPL package contents for on-page reading. Use Open original for the raw FDA ZIP/XML source.

Sponsor
ZYVET AH, Inc.
ANADA
200-787
Status
RX
Form
Chewable Tablets
Route
Oral
Species
Dog, No Use Class Stated Or Implied
Composition / specifications
25, 50, or 75 mg phenylpropanolamine hydrochloride per tablet

Dogs

Indication

For the control of urinary incontinence due to urethral sphincter hypotonus in dogs.

Dosage

The total recommended dosage for oral administration is 2 mg/kg (0.91 mg/lb) of body weight twice daily. Phenylpropanolamine Hydrochloride is scored and dosage should be calculated in half-tablet increments.

PROIN ER™

SPL · SPL

Open original
FDA Structured Product Label

PROIN ER™

Rendered from Roxee's cached FDA SPL package contents for on-page reading. Use Open original for the raw FDA ZIP/XML source.

Sponsor
Pegasus Laboratories, Inc.
NADA
141-517
Status
RX
Form
Tablet
Route
Oral
Species
Dog, No Use Class Stated Or Implied
Composition / specifications
18, 38, 74, or 145 mg of phenylpropanolamine hydrochloride per tablet

Dogs

Indication

For the control of urinary incontinence due to urethral sphincter hypotonus in dogs.

Dosage

The recommended dosage is 2 to 4 mg/kg (0.9 to 1.8 mg/lb) of body weight once daily. Administer with food. Do not split or crush tablets. Dogs weighing less than 10 pounds cannot be safely dosed because tablet administration would result in a dose over 4 mg/kg.

PROIN® Chewable Tablets

SPL · SPL

Open original
FDA Structured Product Label

PROIN® Chewable Tablets

Rendered from Roxee's cached FDA SPL package contents for on-page reading. Use Open original for the raw FDA ZIP/XML source.

Sponsor
Pegasus Laboratories, Inc.
NADA
141-324
Status
RX
Form
Scored Chewable Tablets
Route
Oral
Species
Dog, No Use Class Stated Or Implied
Composition / specifications
Each chewable tablet contains 25, 50, or 75 milligram (mg) phenylpropanolamine hydrochloride.

Dogs

Indication
For the control of urinary incontinence due to urethral sphincter hypotonus in dogs.
Dosage
The total recommended dosage for oral administration is 2 mg/kg (0.91 mg/lb) of body weight twice daily. The dosage should be calculated in half-tablet increments.
Limitations
Federal law restricts this drug to use by or on the order of a licensed veterinarian.For oral use in dogs only.

FOI Summary oA 200-787 Approved June 11, 2024.pdf

FOI · FOI

Open original

FOI Summary oN 141-517 Approved March 29, 2019.pdf

FOI · FOI

Open original

UCM296349.pdf

FOI · FOI

Open original
Source metadata:
Veterinary reference (advanced)

Canonical medication sections are above. This legacy block remains available for deeper cross-reference without cluttering the primary workflow.

At a Glance

Quick facts and links to official labeling and safety signals.

Data freshness
  • Storefront facts: Source Roxee | Refreshed May 5, 2026, 10:00 AM UTC
    The storefront fact projection used for browse cards and quick facts.
  • Animal Drugs @ FDA: Source FDA | Refreshed May 5, 2026, 10:00 AM UTC
    Applications/products are imported from FDA export data.
  • Animal Drugs @ FDA previews: Source FDA | Refreshed Feb 9, 2026, 3:05 AM UTC
    Label highlights/doc links are fetched from FDA preview endpoints.
  • openFDA reaction terms: Source FDA openFDA | Refreshed May 5, 2026, 10:04 AM UTC
  • openFDA case summaries: Source FDA openFDA | Refreshed May 5, 2026, 10:04 AM UTC
Official (FDA)
Identity: Generic ingredient • No FDA branded products linked
No official FDA brand rows linked yet for this ingredient.
Case-reported brands (openFDA): MSK
Catalog species: Both • FDA-labeled species: Dog
Rx/OTC: RX
Form/route: Chewable Tablets, Scored Chewable Tablets, Tablet • Oral
Applications: ANADA 200-787 • NADA 141-517 • NADA 141-324
Documents: 3 (FOI: 3) • SPL: 3 • Label highlights • Official documents
Safety (openFDA)
Top reactions: Dog 46 • Cat 0 • View
Case summaries: 8 (showing 8) • View
openFDA reports are unverified and do not prove causation.
Explore
Linked using: Fda_Label (0.95)
Diagnosis Codes

Diagnosis-code mappings are not available for this medication yet.

Counseling and Monitoring Highlights

Global Pet owner/Vet mode is controlled in the header. This section avoids duplicate in-page persona tabs.

Owner-facing counseling points
  • Federal law restricts this drug to use by or on the order of a licensed veterinarian.For oral use in dogs only. (Contraindication, High)
Top reaction signals
Vomiting (1) Unsteady walking (ataxia) (1) Tiredness (lethargy) (1) Low creatinine (1) Limb non-weight bearing (1) Inappropriate urination (1) Inappropriate defecation (1) Hyperphosphataemia (1)

Identifiers & Packages

Normalized identifiers (NDC/NADA/ANADA) and package metadata from regulator listings.

Identifiers
ANADA: 200787 NADA: 141324 NADA: 141517 NDC Package: 49427-141-48 NDC Package: 49427-141-50 NDC Package: 49427-315-48 NDC Package: 49427-315-50 NDC Package: 49427-316-48 NDC Package: 49427-316-50 NDC Package: 49427-344-44 NDC Package: 49427-344-57 NDC Package: 49427-345-44 NDC Package: 49427-345-57 NDC Package: 49427-346-44 NDC Package: 49427-346-57 NDC Package: 49427-347-44 NDC Package: 49427-347-57 NDC Package: 86117-042-05 NDC Package: 86117-042-09 NDC Package: 86117-043-05 NDC Package: 86117-043-09 NDC Package: 86117-044-05 NDC Package: 86117-044-09 NDC Package: 86136-127-36
Package NDC Product NDC Form / Route Status
49427-141-48 49427 -
49427-141-50 49427 -
49427-315-48 49427 -
49427-315-50 49427 -
49427-316-48 49427 -
49427-316-50 49427 -
49427-344-44 49427 -
49427-344-57 49427 -
49427-345-44 49427 -
49427-345-57 49427 -
49427-346-44 49427 -
49427-346-57 49427 -
49427-347-44 49427 -
49427-347-57 49427 -
86117-042-05 86117 -
86117-042-09 86117 -
86117-043-05 86117 -
86117-043-09 86117 -
86117-044-05 86117 -
86117-044-09 86117 -

Enriched Documents

Documents are tiered by source trust: Official, Clinical, Manufacturer, Marketing.

Data Sources & Change Log

Every non-trivial field is expected to include provenance and update timestamps.

Official 20 Clinical 1 Manufacturer 0 Marketing 0
Current Field Facts
  • side_effects: Top reported reactions (openFDA): Lack of efficacy - NOS, Vomiting, Panting, Diarrhoea, Lethargy (see also Central nervous system depression in 'Neurological')… (Clinical, 2026-04-11)
  • contraindications: Federal law restricts this drug to use by or on the order of a licensed veterinarian.For oral use in dogs only. (Official, 2026-04-12)
  • contraindications: Federal law restricts this drug to use by or on the order of a licensed veterinarian.For oral use in dogs only. (Official, 2026-04-11)
  • contraindications: Federal law restricts this drug to use by or on the order of a licensed veterinarian.For oral use in dogs only. (Official, 2026-02-12)
  • indications: For the control of urinary incontinence due to urethral sphincter hypotonus in dogs For the control of urinary incontinence due to urethral sphincter hypotonus… (Official, 2026-05-05)
  • indications: For the control of urinary incontinence due to urethral sphincter hypotonus in dogs For the control of urinary incontinence due to urethral sphincter hypotonus… (Official, 2026-05-03)
  • indications: For the control of urinary incontinence due to urethral sphincter hypotonus in dogs For the control of urinary incontinence due to urethral sphincter hypotonus… (Official, 2026-05-02)
  • indications: For the control of urinary incontinence due to urethral sphincter hypotonus in dogs For the control of urinary incontinence due to urethral sphincter hypotonus… (Official, 2026-04-29)
  • indications: For the control of urinary incontinence due to urethral sphincter hypotonus in dogs For the control of urinary incontinence due to urethral sphincter hypotonus… (Official, 2026-04-28)
  • indications: For the control of urinary incontinence due to urethral sphincter hypotonus in dogs For the control of urinary incontinence due to urethral sphincter hypotonus… (Official, 2026-04-27)
  • indications: For the control of urinary incontinence due to urethral sphincter hypotonus in dogs For the control of urinary incontinence due to urethral sphincter hypotonus… (Official, 2026-04-26)
  • indications: For the control of urinary incontinence due to urethral sphincter hypotonus in dogs For the control of urinary incontinence due to urethral sphincter hypotonus… (Official, 2026-04-25)
  • indications: For the control of urinary incontinence due to urethral sphincter hypotonus in dogs For the control of urinary incontinence due to urethral sphincter hypotonus… (Official, 2026-04-22)
  • side_effects: Top reported reactions (openFDA): Lack of efficacy - NOS, Vomiting, Panting, Diarrhoea, Lethargy (see also Central nervous system depression in 'Neurological')… (Official, 2026-04-12)
  • side_effects: Top reported reactions (openFDA): Lack of efficacy - NOS, Vomiting, Panting, Diarrhoea, Lethargy (see also Central nervous system depression in 'Neurological')… (Official, 2026-02-12)
  • usage: For the control of urinary incontinence due to urethral sphincter hypotonus in dogs. (Official, 2026-04-12)
  • usage: For the control of urinary incontinence due to urethral sphincter hypotonus in dogs. (Official, 2026-04-11)
  • usage: For the control of urinary incontinence due to urethral sphincter hypotonus in dogs. (Official, 2026-02-12)
Recent Revisions
  • side_effects updated 2026-04-12 10:05 by etl_backfill • Backfilled from existing medication fields
  • contraindications updated 2026-04-12 10:05 by etl_backfill • Backfilled from existing medication fields
  • usage updated 2026-04-12 10:05 by etl_backfill • Backfilled from existing medication fields
  • side_effects updated 2026-04-11 10:05 by etl_backfill • Backfilled from existing medication fields
  • contraindications updated 2026-04-11 10:05 by etl_backfill • Backfilled from existing medication fields
  • usage updated 2026-04-11 10:05 by etl_backfill • Backfilled from existing medication fields
  • side_effects updated 2026-02-12 22:44 by etl_backfill • Backfilled from existing medication fields
  • contraindications updated 2026-02-12 22:44 by etl_backfill • Backfilled from existing medication fields
  • usage updated 2026-02-12 22:44 by etl_backfill • Backfilled from existing medication fields

FDA Products & Applications (Animal Drugs @ FDA)

Official sponsor/proprietary-name/application-status records linked by active ingredient.

Product Sponsor Application Status Published
Phenylpropanolamine Hydrochloride
RX
Phenylpropanolamine hydrochloride
Chewable Tablets • Oral
Label highlights
Official documents
ZYVET AH, Inc. ANADA 200-787 Approved Jul 1, 2024
PROIN ER™
RX
Phenylpropanolamine hydrochloride
Tablet • Oral
Label highlights
Official documents
Pegasus Laboratories, Inc. NADA 141-517 Approved Apr 1, 2019
PROIN® Chewable Tablets
RX
Phenylpropanolamine hydrochloride
Scored Chewable Tablets • Oral
Label highlights
Official documents
Pegasus Laboratories, Inc. NADA 141-324 Approved Jun 1, 2016

Data source: FDA Animal Drugs @ FDA (public search export).

What It's For (FDA Label Highlights)

Extracted from FDA Animal Drugs @ FDA product labeling. Always confirm details with your veterinarian.

Species: Dog, No Use Class Stated Or Implied
Composition / specifications
25, 50, or 75 mg phenylpropanolamine hydrochloride per tablet
Dogs
Indication

For the control of urinary incontinence due to urethral sphincter hypotonus in dogs.

Dosage

The total recommended dosage for oral administration is 2 mg/kg (0.91 mg/lb) of body weight twice daily. Phenylpropanolamine Hydrochloride is scored and dosage should be calculated in half-tablet increments.

Limitations

FDA page: Open in Animal Drugs @ FDA

Species: Dog, No Use Class Stated Or Implied
Composition / specifications
18, 38, 74, or 145 mg of phenylpropanolamine hydrochloride per tablet
Dogs
Indication

For the control of urinary incontinence due to urethral sphincter hypotonus in dogs.

Dosage

The recommended dosage is 2 to 4 mg/kg (0.9 to 1.8 mg/lb) of body weight once daily. Administer with food. Do not split or crush tablets. Dogs weighing less than 10 pounds cannot be safely dosed because tablet administration would result in a dose over 4 mg/kg.

Limitations

FDA page: Open in Animal Drugs @ FDA

Species: Dog, No Use Class Stated Or Implied
Composition / specifications
Each chewable tablet contains 25, 50, or 75 milligram (mg) phenylpropanolamine hydrochloride.
Dogs
Indication
For the control of urinary incontinence due to urethral sphincter hypotonus in dogs.
Dosage
The total recommended dosage for oral administration is 2 mg/kg (0.91 mg/lb) of body weight twice daily. The dosage should be calculated in half-tablet increments.
Limitations
Federal law restricts this drug to use by or on the order of a licensed veterinarian.For oral use in dogs only.

FDA page: Open in Animal Drugs @ FDA

Usage

For the control of urinary incontinence due to urethral sphincter hypotonus in dogs.

Source: FDA Animal Drugs @ FDA • Reference

Contraindications

Federal law restricts this drug to use by or on the order of a licensed veterinarian.For oral use in dogs only.

Top Reported Reactions (openFDA)

De-duplicated reaction terms grouped by body system from FDA openFDA reports (not verified; does not prove causation).

Digestive
Vomiting (1) • Dog Diarrhea (1) • Dog

Showing top 5 for Digestive.

Neurologic
Unsteady walking (1) • Dog Tiredness (1) • Dog Grand mal seizure (1) • Dog

Showing top 5 for Neurologic.

Behavior
Biting -aggression (1) • Dog Behavioral disorder (1) • Dog Anxiety (1) • Dog

Showing top 5 for Behavior.

Effectiveness
Lack of efficacy - NOS (1) • Dog

Showing top 5 for Effectiveness.

Other
Lying down (1) • Dog Low creatinine (1) • Dog Limb non-weight bearing (1) • Dog Inappropriate urination (1) • Dog Inappropriate defecation (1) • Dog
Show more (18)
Hyperphosphataemia (1) • Dog High leg gait (1) • Dog Growling (1) • Dog Frequent urination (1) • Dog Falling (1) • Dog Eosinophilia (1) • Dog Elevated serum alkaline phosphatase (1) • Dog Elevated renal parameters (1) • Dog Elevated alanine aminotransferase (1) • Dog Drug dose administration interval too short (1) • Dog Dilated pupils (1) • Dog Difficulty standing (1) • Dog Difficulty going up/down stairs (1) • Dog Decreased cholesterol (1) • Dog Cough (1) • Dog Cognitive disorder NOS (1) • Dog Accidental exposure (1) • Dog Abnormal posture NOS (1) • Dog

Showing top 5 for Other.

Data source: FDA openFDA Animal & Veterinary adverse event reports.

Adverse Event Case Summaries (openFDA)

These are individual FDA adverse event reports. They are unverified and do not prove the medication caused the reaction.

Dog, Shepherd Dog - German, Female, 11 year, 20.865 kilogram • Drug: MSK, Unassigned, Unknown • Reactions: Vomiting, Not eating, Tiredness (lethargy), Reluctant to move, Seizure NOS • Outcome: Ongoing

  • Report ID: USA-USFDACVM-2025-US-075421
  • Serious AE: Yes
  • Treated For AE: No
  • Sex: Female
  • Age: 11.00 Year
  • Weight: 20.865 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Unknown
  • Form: Unassigned
Reactions Reported:
Vomiting Not eating Tiredness (lethargy) Reluctant to move Seizure NOS
Outcomes: Ongoing

Dog, Bulldog - English, Female, 11.2 year, 29.94 kilogram • Drug: MSK, Unassigned, Unknown • Reactions: Urinary incontinence • Outcome: Ongoing

  • Report ID: USA-USFDACVM-2025-US-075305
  • Serious AE: No
  • Treated For AE: No
  • Sex: Female
  • Age: 11.20 Year
  • Weight: 29.940 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Unknown
  • Form: Unassigned
Reactions Reported:
Urinary incontinence
Outcomes: Ongoing

Dog, ['Shepherd Dog - German', 'Siberian Husky'], Female, 9 year, 34.019 kilogram • Drug: MSK, Unassigned, Oral • Reactions: Difficulty going up/down stairs, Lying down, High leg gait • Outcome: Outcome Unknown

  • Report ID: USA-USFDACVM-2025-US-074392
  • Serious AE: No
  • Treated For AE: No
  • Sex: Female
  • Age: 9.00 Year
  • Weight: 34.019 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Oral
  • Form: Unassigned
Reactions Reported:
Difficulty going up/down stairs Lying down High leg gait
Outcomes: Outcome Unknown

Dog, ['Pointer (unspecified)', 'Collie - Border'], Female, 15 year, 22.68 kilogram • Drug: MSK, Unassigned, Unknown • Reactions: Anxiety, Vocalisation, Behavioral disorder (unspecified), Diarrhea, Biting -aggression… • Outcome: Outcome Unknown

  • Report ID: USA-USFDACVM-2025-US-072884
  • Serious AE: Yes
  • Treated For AE: Yes
  • Sex: Female
  • Age: 15.00 Year
  • Weight: 22.680 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Unknown
  • Form: Unassigned
Reactions Reported:
Anxiety Vocalisation Behavioral disorder (unspecified) Diarrhea Biting -aggression Pacing Frequent urination Inappropriate defecation Inappropriate urination Cognitive disorder NOS Seizure NOS Vocalizing while sleeping Unconscious Nystagmus Difficulty standing Unable to walk Vestibular disorder NOS Limb non-weight bearing Falling Urinary incontinence Medication error NOS Panting Abnormal posture NOS
Outcomes: Outcome Unknown

Dog, ['Collie - Border', 'Dog (unknown)'], Female, 14 year, 20.321 kilogram • Drug: MSK, Unassigned, Unknown • Reactions: Tiredness (lethargy), Growling, Biting -aggression, Not himself/herself, Pacing… • Outcome: Ongoing

  • Report ID: USA-USFDACVM-2025-US-071646
  • Serious AE: Yes
  • Treated For AE: Yes
  • Sex: Female
  • Age: 14.00 Year
  • Weight: 20.321 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Unknown
  • Form: Unassigned
Reactions Reported:
Tiredness (lethargy) Growling Biting -aggression Not himself/herself Pacing Cough Vomiting Regurgitation Weakness Unsteady walking (ataxia) Not eating Elevated alanine aminotransferase Elevated serum alkaline phosphatase Elevated renal parameters Hyperphosphataemia Unable to walk
Outcomes: Ongoing

Dog, ['Retriever (unspecified)', 'Dog (unknown)'], Female, 13 year, 38.555 kilogram • Drug: MSK, Unknown • Reactions: Urinary incontinence • Outcome: Ongoing

  • Report ID: USA-USFDACVM-2025-US-070900
  • Serious AE: No
  • Treated For AE: Yes
  • Sex: Female
  • Age: 13.00 Year
  • Weight: 38.555 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Unknown
Reactions Reported:
Urinary incontinence
Outcomes: Ongoing

Dog, Pointing Dog - German (unspecified), Male, 20 month, 30.391 kilogram • Drug: MSK, Tablet, chewable, Oral, Dose: 1 tablet per dose, Frequency: 1 per day • Reactions: Vomiting, Underdose • Outcome: Recovered/Normal

  • Report ID: CAN-USFDACVM-2025-CA-000112
  • Serious AE: No
  • Treated For AE: No
  • Sex: Male
  • Age: 20.00 Month
  • Weight: 30.391 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Oral
  • Form: Tablet, chewable
  • Dose: 1 tablet per dose
  • Frequency: 1 per day
Reactions Reported:
Vomiting Underdose
Outcomes: Recovered/Normal

Dog, Shepherd (unspecified), Female, 15.42 year, 23.13 kilogram • Drug: MSK, Unassigned, Unknown • Reactions: Vaginal haemorrhage, Renal degeneration, Mass NOS, Thrombosis • Outcome: Ongoing

  • Report ID: USA-USFDACVM-2025-US-070127
  • Serious AE: No
  • Treated For AE: No
  • Sex: Female
  • Age: 15.42 Year
  • Weight: 23.130 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Unknown
  • Form: Unassigned
Reactions Reported:
Vaginal haemorrhage Renal degeneration Mass NOS Thrombosis
Outcomes: Ongoing

Data source: FDA openFDA Animal & Veterinary adverse event reports.

Overdose Information

No approved overdose-management text is linked yet. If overdose is suspected, contact a veterinarian or emergency clinic immediately.

Storage & Handling

No approved storage guidance is linked yet for this ingredient. Use manufacturer packaging and veterinary guidance for handling/storage.

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