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Roxee Meds Catalog

Propofol

Medication catalog facts with explicit FDA-approval, off-label, source-limited, and safety context.

Both Catalog complete FDA data linked Rx required Liquid (Emulsion) Multiple FDA labelers Official label facts Owner quick guide first
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Data freshness

Storefront facts
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May 5, 2026, 10:00 a.m.

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FDA applications
FDA application data refreshed
May 5, 2026, 10:00 a.m.

Sponsor, product, and application records imported from Animal Drugs @ FDA.

Safety reports
Safety data refreshed
May 5, 2026, 10:01 a.m.

openFDA reaction terms and case summaries are supporting evidence, not proof of causality.

Source timing details
Source timing details
  • Storefront facts: Source Roxee | Refreshed May 5, 2026, 10:00 AM UTC
    The storefront fact projection used for browse cards and quick facts.
  • Animal Drugs @ FDA: Source FDA | Refreshed May 5, 2026, 10:00 AM UTC
    Applications/products are imported from FDA export data.
  • Animal Drugs @ FDA previews: Source FDA | Refreshed Feb 9, 2026, 3:05 AM UTC
    Label highlights/doc links are fetched from FDA preview endpoints.
  • Animal Drug Product Listing Directory (NDC): Source FDA | Refreshed May 5, 2026, 10:00 AM UTC
    Package/product NDCs from FDA’s electronic listing directory (XLS).
  • openFDA reaction terms: Source FDA openFDA | Refreshed May 5, 2026, 10:04 AM UTC
  • openFDA case summaries: Source FDA openFDA | Refreshed May 5, 2026, 10:04 AM UTC

Evidence

Reviewed / Updated / Sources

Reviewed by: Not available

Last reviewed: February 12, 2026

Updated: February 12, 2026, 10:44 PM UTC

Sources:
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Propofol

Propofol

Drug type: Generic ingredient • Branded profile • FDA branded products available

Both Liquid (Emulsion) Rx required 100% storefront ready

Species: Both

Manufacturer: Multiple FDA labelers

Medication Snapshot

Merged from the current Roxee medication system with field-level provenance, freshness, and completeness tracking.

Propofol

The drug is indicated for use as an anesthetic as follows: As a single injection to provide general anesthesia for short procedures, for induction and maintenance of general anesthesia using incremental doses to effect, and for induction of general anesthesia where maintenance is provided by inhalant anesthetics. The drug is indicated for use as an anesthetic as follows: As a single injection to provide general anesthesia for procedures lasting up to 5 minutes; for induction and maintenance of general anesthesia using incremental doses to effect; for induction of general anesthesia where maintenance is provided by inhalant anesthetics. For induction of anesthesia. For maintenance of general anesthesia for up to 20 minutes. For induction of general anesthesia where maintenance is provided by inhalant anesthetics. Species commonly shown: Both, Dog, No Use Class Stated Or Implied, Cat, No Use Class Stated Or Implied.

Generic name
Propofol
Brand names
Rapanofal®, PropoFlo™ 28 PropoFlo™, PropoClear™, PropofolVet Multidose
Manufacturer
Multiple FDA labelers
Species
Both, Dog, No Use Class Stated Or Implied, Cat, No Use Class Stated Or Implied
Dosage forms
Liquid (Emulsion), Microemulsion, Injectable emulsion
Prescription
Prescription required
Completeness
100%
Validation
Complete
Brand names
Rapanofal® PropoFlo™ 28 PropoFlo™ PropoClear™ PropofolVet Multidose PropoFlo 28 PropoFlo Rapanofal Propofol Propovan CF
Dosage forms
Liquid (Emulsion) Microemulsion Injectable emulsion

Indications / Uses

The drug is indicated for use as an anesthetic as follows: As a single injection to provide general anesthesia for short procedures, for induction and maintenance of general anesthesia using incremental doses to effect, and for induction of general anesthesia where maintenance is provided by inhalant anesthetics. The drug is indicated for use as an anesthetic as follows: As a single injection to provide general anesthesia for procedures lasting up to 5 minutes; for induction and maintenance of general anesthesia using incremental doses to effect; for induction of general anesthesia where maintenance is provided by inhalant anesthetics. For induction of anesthesia. For maintenance of general anesthesia for up to 20 minutes. For induction of general anesthesia where maintenance is provided by inhalant anesthetics.

Warnings / Contraindications

Adequate data concerning safe use of propofol in pregnant and breeding cats have not been obtained. Doses may need adjustment for geriatric or debilitated patients. Federal law restricts this drug to use by or on the order of a licensed veterinarian. Adequate data concerning safe use of propofol in pregnant and breeding dogs have not been obtained. Doses may need adjustment for geriatric or debilitated patients. Federal (USA) law restricts this drug to use by or on the order of a licensed veterinarian. Administer by intravenous injection only. Rapid bolus administration (induction or maintenance) or accidental overdosage of propofol may cause undesirable cardiorespiratory depression including hypotension and oxygen desaturation. Respiratory arrest (apnea) could occur. When using propofol, dogs should be continuously monitored and facilities for the maintenance of a patent airway, artificial ventilation, and oxygen supplementation must be immediately available. The use of propofol in pregnant and breeding dogs has not been evaluated. Propofol crosses the placenta and, as with other general anesthetic agents, the administration of propofol may be associated with neonatal depression. Propofol has not been evaluated in dogs less than 10 weeks of age

  • Adequate data concerning safe use of propofol in pregnant and breeding cats have not been obtained. Doses may need adjustment for geriatric or debilitated patients. Federal law restricts this drug to use by or on the order of a licensed veterinarian. Adequate data concerning safe use of propofol in pregnant and breeding dogs have not been obtained. Doses may need adjustment for geriatric or debilitated patients. Federal (USA) law restricts this drug to use by or on the order of a licensed veterinarian. Administer by intravenous injection only. Rapid bolus administration (induction or maintenance) or accidental overdosage of propofol may cause undesirable cardiorespiratory depression including hypotension and oxygen desaturation. Respiratory arrest (apnea) could occur. When using propofol, dogs should be continuously monitored and facilities for the maintenance of a patent airway, artificial ventilation, and oxygen supplementation must be immediately available. The use of propofol in pregnant and breeding dogs has not been evaluated. Propofol crosses the placenta and, as with other general anesthetic agents, the administration of propofol may be associated with neonatal depression. Propofol has not been evaluated in dogs less than 10 weeks of age

Side Effects

Top reported reactions (openFDA): Death, Vomiting, Lack of efficacy - NOS, Bradycardia, Seizure NOS, Diarrhoea.

FAQ

Both, Dog, No Use Class Stated Or Implied, Cat, No Use Class Stated Or Implied

Yes. Roxee shows this as prescription-only.

Liquid (Emulsion), Microemulsion, Injectable emulsion

Source Transparency

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Pet Owner Quick Guide

Start here first for the safest next-step summary before the deeper medication detail.

Used for:

For induction of anesthesia. For maintenance of general anesthesia by intermittent bolus injections for short procedures. For induction of general anesthesia where maintenance is provided by inhalant anesthetics.

Dosing note:

Exact dosing depends on your pet's species, weight, and health status. Use your veterinarian's instructions for the exact dose and schedule.

What to watch for:

  • Adequate data concerning safe use of propofol in pregnant and breeding cats have not been obtained
  • Doses may need adjustment for geriatric or debilitated patients
  • Adequate data concerning safe use of propofol in pregnant and breeding dogs have not been obtained
  • Federal (USA) law restricts this drug to use by or on the order of a licensed veterinarian
  • Administer by intravenous injection only
  • Rapid bolus administration (induction or maintenance) or accidental overdosage of propofol may cause undesirable cardiorespiratory depression including hypotension and oxygen desaturation
  • Respiratory arrest (apnea) could occur
  • When using propofol, dogs should be continuously monitored and facilities for the maintenance of a patent airway, artificial ventilation, and oxygen supplementation must be immediately available
  • The use of propofol in pregnant and breeding dogs has not been evaluated
  • Propofol crosses the placenta and, as with other general anesthetic agents, the administration of propofol may be associated with neonatal depression
  • Propofol has not been evaluated in dogs less than 10 weeks of age
  • trouble breathing (1 reports)
  • Loss of appetite (1 reports)
  • Elevated temperature (1 reports)

When to call the vet:

  • Repeated vomiting or diarrhea.
  • Severe lethargy (hard to wake, very low energy).
  • Collapse or fainting.
  • Facial swelling or hives.
  • Blood in vomit or stool.

Regulatory restrictions are shown in Vet View.

What to tell or ask your vet today:

  • Is this medicine the right fit for my pet’s current symptoms?
  • Which warning signs mean I should call back right away?
  • How should I handle missed doses or refusal to take the medicine?
Major cautions & emergency warning signs

Side effects to monitor:

  • Adequate data concerning safe use of propofol in pregnant and breeding cats have not been obtained
  • Doses may need adjustment for geriatric or debilitated patients
  • Adequate data concerning safe use of propofol in pregnant and breeding dogs have not been obtained
  • Federal (USA) law restricts this drug to use by or on the order of a licensed veterinarian
  • Administer by intravenous injection only

Most reported reactions:

  • Trouble breathing (dyspnea) (1 reports)
  • Loss of appetite (1 reports)
  • Elevated temperature (1 reports)

Emergency warning signs:

  • Repeated vomiting or diarrhea.
  • Severe lethargy (hard to wake, very low energy).
  • Collapse or fainting.
  • Facial swelling or hives.
Talk to a Vet / Find a Vet Near You Start Symptom Intake

Quick Facts

Official label facts first, then secondary summaries. Marketing content is separated below.

Species: Both
Manufacturer: Multiple FDA labelers
Form: Injectable emulsion, Liquid (Emulsion), Microemulsion
Identifiers:
ANADA: 200793 NADA: 141070 NADA: 141098 NADA: 141303 NDC Package: 11695-2801-1 NDC Package: 11695-7036-1 NDC Package: 13985-740-23 NDC Package: 54771-4944-1 NDC Package: 54771-4944-2 NDC Package: 54771-5206-1 NDC Package: 68504-008-01 NDC Package: 86064-001-20 NDC Package: 86136-136-31 NDC Product: 11695 NDC Product: 13985 NDC Product: 54771 NDC Product: 68504 NDC Product: 86064 NDC Product: 86136
Source metadata:

Warnings / Contraindications

Adequate data concerning safe use of propofol in pregnant and breeding cats have not been obtained. Doses may need adjustment for geriatric or debilitated patients. Federal law restricts this drug to use by or on the order of a licensed veterinarian. Adequate data concerning safe use of propofol in pregnant and breeding dogs have not been obtained. Doses may need adjustment for geriatric or debilitated patients. Federal (USA) law restricts this drug to use by or on the order of a licensed veterinarian. Administer by intravenous injection only. Rapid bolus administration (induction or maintenance) or accidental overdosage of propofol may cause undesirable cardiorespiratory depression including hypotension and oxygen desaturation. Respiratory arrest (apnea) could occur. When using propofol, dogs should be continuously monitored and facilities for the maintenance of a patent airway, artificial ventilation, and oxygen supplementation must be immediately available. The use of propofol in pregnant and breeding dogs has not been evaluated. Propofol crosses the placenta and, as with other general anesthetic agents, the administration of propofol may be associated with neonatal depression. Propofol has not been evaluated in dogs less than 10 weeks of age

  • High: Adequate data concerning safe use of propofol in pregnant and breeding cats have not been obtained. Doses may need adjustment for geriatric or debilitated patients. Federal law restricts this drug to use by or on the order of a licensed veterinarian. Adequate data concerning safe use of propofol in pregnant and breeding dogs have not been obtained. Doses may need adjustment for geriatric or debilitated patients. Federal (USA) law restricts this drug to use by or on the order of a licensed veterinarian. Administer by intravenous injection only. Rapid bolus administration (induction or maintenance) or accidental overdosage of propofol may cause undesirable cardiorespiratory depression including hypotension and oxygen desaturation. Respiratory arrest (apnea) could occur. When using propofol, dogs should be continuously monitored and facilities for the maintenance of a patent airway, artificial ventilation, and oxygen supplementation must be immediately available. The use of propofol in pregnant and breeding dogs has not been evaluated. Propofol crosses the placenta and, as with other general anesthetic agents, the administration of propofol may be associated with neonatal depression. Propofol has not been evaluated in dogs less than 10 weeks of age
Source metadata:

Adverse Reactions

Snapshot first, detailed rows second. This section summarizes signal data and is not a diagnosis.

Tap or hover a reaction to see what it means in plain language.

Tracked signals
32
Reported cases
32
Serious reports
26
Species represented
2
Grouped by Body System
Digestive (5) · Loss of appetite, Drooling, Diarrhea Skin & allergy (1) · Application site hair loss Behavior (1) · Behavioral disorder (unspecified) Other (25) · Trouble breathing (dyspnea), Elevated temperature, Elevated serum alkaline phosphatase
Most Reported Reactions
Reaction Body system Cases Species Serious cases
Other 1 Dog 1
Digestive 1 Dog 1
Other 1 Cat 1
Other 1 Dog 1
Other 1 Cat 1
Other 1 Cat 1
Digestive 1 Dog 1
Other 1 Cat 1

Species coverage: Cat (17) Dog (15)

View detailed reaction table
Reaction Body system Species Seriousness Frequency Reports
Other Dog Serious - 1
Digestive Dog Serious - 1
Other Cat Serious - 1
Other Dog Serious - 1
Other Cat Non-serious - 1
Other Cat Serious - 1
Other Cat Serious - 1
Digestive Dog Serious - 1
Other Cat Serious - 1
Digestive Dog Non-serious - 1
Other Dog Serious - 1
Other Cat Serious - 1
Other Dog Serious - 1
Other Cat Serious - 1
Digestive Dog Serious - 1
Other Cat Serious - 1
Other Cat Serious - 1
Other Dog Serious - 1
Other Dog Serious - 1
Other Cat Serious - 1
Other Dog Serious - 1
Other Cat Serious - 1
Digestive Cat Serious - 1
Other Cat Serious - 1
Behavior Cat Serious - 1
Other Dog Serious - 1
Other Cat Non-serious - 1
Skin & allergy Cat Non-serious - 1
Other Cat Non-serious - 1
Other Dog Serious - 1
Other Dog Serious - 1
Other Dog Non-serious - 1
Source metadata:

Documents

Owner handouts and official technical documents open on-page first, with the original source still one click away.

Owner handouts

0
No owner handouts linked yet.

Official label / PI

0
No official label or package insert links yet.

SPL

10

FOI

6

PropofolVet Multidose

SPL · SPL

Open original
FDA Structured Product Label

PropofolVet Multidose

Rendered from Roxee's cached FDA SPL package contents for on-page reading. Use Open original for the raw FDA ZIP/XML source.

Sponsor
Parnell Technologies Pty. Ltd.
ANADA
200-793
Status
RX
Form
Injectable emulsion
Route
Intravenous
Composition / specifications
10 mg/mL propofol

Dogs

Indication

For induction of anesthesia. For maintenance of general anesthesia by intermittent bolus injections for short procedures. For induction of general anesthesia where maintenance is provided by inhalant anesthetics.

Dosage

For induction of general anesthesia without the use of preanesthetics, the dosage is 7.6 milligrams per kilogram titrated against the response of the patient over 60-90 seconds or until clinical signs show the onset of anesthesia (5.0 to 7.6 mg/kg/min).The use of preanesthetic medication reduces propofol dose requirements. For the maintenance of general anesthesia without the use of preanesthetics, the dosage is 3.2 milligrams per kilogram The use of preanesthetic medication reduces propofol dose requirements. Due to the rapid metabolism of propofol, additional low doses of propofol, similar to those used for maintenance with propofol, may be required to complete the transition to inhalant maintenance anesthesia.

Rapanofal®

SPL · SPL

Open original
FDA Structured Product Label

Rapanofal®

Rendered from Roxee's cached FDA SPL package contents for on-page reading. Use Open original for the raw FDA ZIP/XML source.

Sponsor
IVAOES, INC. DBA IVAOES ANIMAL HEALTH
NADA
141-070
Status
RX
Form
Liquid (Emulsion)
Route
Intravenous
Species
Dog, No Use Class Stated Or Implied • Cat, No Use Class Stated Or Implied
Composition / specifications
The drug is a sterile, nonpyrogenic, oil-in-water emulsion containing 10 milligrams of propofol per milliliter.

Cats

Indication
The drug is indicated for use as an anesthetic as follows: As a single injection to provide general anesthesia for short procedures, for induction and maintenance of general anesthesia using incremental doses to effect, and for induction of general anesthesia where maintenance is provided by inhalant anesthetics.
Dosage
The drug is administered by intravenous injection as follows: For induction of general anesthesia without the use of preanesthetics the dosage is 8.0 to 13.2 milligrams per kilogram (3.6 to 6.0 milligrams per pound). For the maintenance of general anesthesia without the use of preanesthetics the dosage is 1.1 to 4.4 milligrams per kilogram (0.5 to 2.0 milligrams per pound). The use of preanesthetic medication reduces propofol dose requirements.
Limitations
Adequate data concerning safe use of propofol in pregnant and breeding cats have not been obtained. Doses may need adjustment for geriatric or debilitated patients. Federal law restricts this drug to use by or on the order of a licensed veterinarian.

Dogs

Indication
The drug is indicated for use as an anesthetic as follows: As a single injection to provide general anesthesia for procedures lasting up to 5 minutes; for induction and maintenance of general anesthesia using incremental doses to effect; for induction of general anesthesia where maintenance is provided by inhalant anesthetics.
Dosage
The drug is administered by intravenous injection as follows: For induction of general anesthesia without the use of preanesthetics the dosage is 5.5 to 7.0 milligrams per kilogram (2.5 to 3.2 milligrams per pound); for the maintenance of general anesthesia without the use of preanesthetics the dosage is 1.1 to 3.3 milligrams per kilogram (0.5 to 1.5 milligrams per pound). The use of preanesthetic medication reduces propofol dose requirements.
Limitations
Adequate data concerning safe use of propofol in pregnant and breeding dogs have not been obtained. Doses may need adjustment for geriatric or debilitated patients.

PropoFlo™ 28

SPL · SPL

Open original
FDA Structured Product Label

PropoFlo™ 28 PropoFlo™

Rendered from Roxee's cached FDA SPL package contents for on-page reading. Use Open original for the raw FDA ZIP/XML source.

Sponsor
Zoetis Inc.
NADA
141-098
Status
RX
Form
Liquid (Emulsion)
Route
Intravenous
Species
Dog, No Use Class Stated Or Implied
Composition / specifications
Each mL contains 10 mg propofol.

Dogs

Indication
For induction of anesthesia. For maintenance of general anesthesia for up to 20 minutes. For induction of general anesthesia where maintenance is provided by inhalant anesthetics.
Dosage
For induction of general anesthesia without the use of preanesthetics, the dosage is 5.5 to 7.6 milligrams per kilogram (2.5 to 3.2 milligrams per pound)The use of preanesthetic medication reduces propofol dose requirements. For the maintenance of general anesthesia without the use of preanesthetics, the dosage is 2.2 to 3.2 milligrams per kilogram (0.5 to 1.5 milligrams per pound. The use of preanesthetic medication reduces propofol dose requirements.
Limitations
Federal (USA) law restricts this drug to use by or on the order of a licensed veterinarian. Administer by intravenous injection only. Rapid bolus administration (induction or maintenance) or accidental overdosage of propofol may cause undesirable cardiorespiratory depression including hypotension and oxygen desaturation. Respiratory arrest (apnea) could occur. When using propofol, dogs should be continuously monitored and facilities for the maintenance of a patent airway, artificial ventilation, and oxygen supplementation must be immediately available. The use of propofol in pregnant and breeding dogs has not been evaluated. Propofol crosses the placenta and, as with other general anesthetic agents, the administration of propofol may be associated with neonatal depression. Propofol has not been evaluated in dogs less than 10 weeks of age

PropoFlo™

SPL · SPL

Open original
FDA Structured Product Label

PropoFlo™ 28 PropoFlo™

Rendered from Roxee's cached FDA SPL package contents for on-page reading. Use Open original for the raw FDA ZIP/XML source.

Sponsor
Zoetis Inc.
NADA
141-098
Status
RX
Form
Liquid (Emulsion)
Route
Intravenous
Species
Dog, No Use Class Stated Or Implied
Composition / specifications
Each mL contains 10 mg propofol.

Dogs

Indication
For induction of anesthesia. For maintenance of general anesthesia for up to 20 minutes. For induction of general anesthesia where maintenance is provided by inhalant anesthetics.
Dosage
For induction of general anesthesia without the use of preanesthetics, the dosage is 5.5 to 7.6 milligrams per kilogram (2.5 to 3.2 milligrams per pound)The use of preanesthetic medication reduces propofol dose requirements. For the maintenance of general anesthesia without the use of preanesthetics, the dosage is 2.2 to 3.2 milligrams per kilogram (0.5 to 1.5 milligrams per pound. The use of preanesthetic medication reduces propofol dose requirements.
Limitations
Federal (USA) law restricts this drug to use by or on the order of a licensed veterinarian. Administer by intravenous injection only. Rapid bolus administration (induction or maintenance) or accidental overdosage of propofol may cause undesirable cardiorespiratory depression including hypotension and oxygen desaturation. Respiratory arrest (apnea) could occur. When using propofol, dogs should be continuously monitored and facilities for the maintenance of a patent airway, artificial ventilation, and oxygen supplementation must be immediately available. The use of propofol in pregnant and breeding dogs has not been evaluated. Propofol crosses the placenta and, as with other general anesthetic agents, the administration of propofol may be associated with neonatal depression. Propofol has not been evaluated in dogs less than 10 weeks of age

PropoClear™

SPL · SPL

Open original
FDA Structured Product Label

PropoClear™

Rendered from Roxee's cached FDA SPL package contents for on-page reading. Use Open original for the raw FDA ZIP/XML source.

Sponsor
Zoetis Inc.
NADA
141-303
Status
RX
Form
Microemulsion
Route
Intravenous
Species
Dog, No Use Class Stated Or Implied • Cat, No Use Class Stated Or Implied
Composition / specifications
Each mL contains 10 mg propofol.

Dogs

Indication
For the induction and maintenance of anesthesia and for induction followed by maintenance with an inhalant anesthetic.
Dosage
Induction of General Anesthesia in Dogs: Induction dose guidelines are 4.0 to 6.5 mg/kg in dogs that do not receive a preanesthetic, and 1.4 to 6.5 mg/kg in dogs that receive a preanesthetic. The mean PROPOCLEAR induction dose is reduced by 20 to 30% for dogs that receive a preanesthetic (dose sparing effect). Anesthesia is usually observed within 60 seconds after the end of the induction dose administration. Duration of anesthesia following the recommended induction dose is approximately 4 minutes without a preanesthetic and 4 to 11 minutes with a preanesthetic. Individual anesthesia times may vary. Maintenance of General Anesthesia in Dogs: Anesthesia can be maintained by administration of PROPOCLEAR using intermittent IV injections. For dogs, the duration of anesthesia following a PROPOCLEAR maintenance dose is approximately 3 to 5 minutes. Clinical response may vary, and is determined by the dose, the rate of administration, and the frequency of maintenance injections. The maintenance dose and frequency should be based on the patient’s response. Sighthounds may need lower maintenance doses of PROPOCLEAR, and the time between maintenance dose administration and for recovery may be longer.
Limitations
Federal law restricts this drug to use by or on the order of a licensed veterinarian. When using propofol, patients should be continuously monitored and facilities for the maintenance of a patient airway, artificial ventilation, and oxygen supplementation must be immediately available.

Cats

Indication
For the induction and maintenance of anesthesia and for induction followed by maintenance with an inhalant anesthetic.
Dosage
Induction of General Anesthesia in Cats: Induction dose guidelines are 4.1 to 8.0 mg/kg for cats that do not receive a preanesthetic, and 2.7 to 8.0 mg/kg for cats that receive a preanesthetic. The PROPOCLEAR induction dose is reduced by 16 to 24% for cats that receive a preanesthetic (dose sparing effect). Anesthesia is usually observed within 60 seconds after the end of the induction dose administration. Duration of anesthesia following the recommended induction dose is approximately 3 minutes without a preanesthetic and 3 to 6 minutes with a preanesthetic. Full standing recovery occurs within approximately 30 minutes in cats. Individual anesthesia times vary. The actual induction dose should be based on patient response. Maintenance of General Anesthesia in Cats: Anesthesia can be maintained by administration of PROPOCLEAR using intermittent IV injections. For cats, the duration of anesthesia following each PROPOCLEAR maintenance dose is approximately 3 to 5 minutes. Clinical response may vary, and is determined by the dose, rate of administration and frequency of maintenance injections. PROPOCLEAR maintenance dose sparing is greater in cats that receive a preanesthetic. The maintenance dose and frequency should be based on the patient’s response.
Limitations
Federal law restricts this drug to use by or on the order of a licensed veterinarian. When using propofol, patients should be continuously monitored and facilities for the maintenance of a patient airway, artificial ventilation, and oxygen supplementation must be immediately available.

Propovan CF SPL

SPL · Structured Product Label

Open original
FDA Structured Product Label XML for Propovan CF. Use the source link for the full official labeling record.

Propofol SPL

SPL · Structured Product Label

Open original
FDA Structured Product Label XML for Propofol. Use the source link for the full official labeling record.

PropoFlo 28 SPL

SPL · Structured Product Label

Open original
FDA Structured Product Label XML for PropoFlo 28. Use the source link for the full official labeling record.

Rapanofal SPL

SPL · Structured Product Label

Open original
FDA Structured Product Label XML for Rapanofal. Use the source link for the full official labeling record.

PropoFlo SPL

SPL · Structured Product Label

Open original
FDA Structured Product Label XML for PropoFlo. Use the source link for the full official labeling record.

FOI Summary oA 200-793 Approved November 18, 2024.pdf

FOI · FOI

Open original

ucm116781.pdf

FOI · FOI

Open original

UCM488658.pdf

FOI · FOI

Open original

UCM248263.pdf

FOI · FOI

Open original

UCM355533.pdf

FOI · FOI

Open original

UCM224476.pdf

FOI · FOI

Open original
Source metadata:
Veterinary reference (advanced)

Canonical medication sections are above. This legacy block remains available for deeper cross-reference without cluttering the primary workflow.

At a Glance

Quick facts and links to official labeling and safety signals.

Data freshness
  • Storefront facts: Source Roxee | Refreshed May 5, 2026, 10:00 AM UTC
    The storefront fact projection used for browse cards and quick facts.
  • Animal Drugs @ FDA: Source FDA | Refreshed May 5, 2026, 10:00 AM UTC
    Applications/products are imported from FDA export data.
  • Animal Drugs @ FDA previews: Source FDA | Refreshed Feb 9, 2026, 3:05 AM UTC
    Label highlights/doc links are fetched from FDA preview endpoints.
  • Animal Drug Product Listing Directory (NDC): Source FDA | Refreshed May 5, 2026, 10:00 AM UTC
    Package/product NDCs from FDA’s electronic listing directory (XLS).
  • openFDA reaction terms: Source FDA openFDA | Refreshed May 5, 2026, 10:04 AM UTC
  • openFDA case summaries: Source FDA openFDA | Refreshed May 5, 2026, 10:04 AM UTC
Official (FDA)
Identity: Generic ingredient • FDA branded products available
Official FDA brands: PropoFlo PropoFlo 28 Propofol Propovan CF Rapanofal
Manufacturer mapping: Multiple FDA labelers
Case-reported brands (openFDA): MSK
Catalog species: Both • FDA-labeled species: Cat, Dog
Rx/OTC: RX
Form/route: Injectable emulsion, Liquid (Emulsion), Microemulsion • Intravenous
Applications: ANADA 200-793 • NADA 141-070 • NADA 141-098 • NADA 141-303
NDC: Packages 11695-2801-1 13985-740-23 54771-4944-1 54771-4944-2 54771-5206-1 86064-001-20 • Products 11695 13985 54771 86064
Documents: 6 (FOI: 6) • SPL: 5 • Label highlights • Official documents
Safety (openFDA)
Top reactions: Dog 31 • Cat 48 • View
Case summaries: 16 (showing 8) • View
openFDA reports are unverified and do not prove causation.
Diagnosis Codes

Diagnosis-code mappings are not available for this medication yet.

Counseling and Monitoring Highlights

Global Pet owner/Vet mode is controlled in the header. This section avoids duplicate in-page persona tabs.

Owner-facing counseling points
  • Adequate data concerning safe use of propofol in pregnant and breeding cats have not been obtained. Doses may need adjustment for geriatric or debilitated patients. Federal law restricts this drug to use by or on the order of a licensed veterinarian. Adequate data concerning safe use of propofol in pregnant and breeding dogs have not been obtained. Doses may need adjustment for geriatric or debilitated patients. Federal (USA) law restricts this drug to use by or on the order of a licensed veterinarian. Administer by intravenous injection only. Rapid bolus administration (induction or maintenance) or accidental overdosage of propofol may cause undesirable cardiorespiratory depression including hypotension and oxygen desaturation. Respiratory arrest (apnea) could occur. When using propofol, dogs should be continuously monitored and facilities for the maintenance of a patent airway, artificial ventilation, and oxygen supplementation must be immediately available. The use of propofol in pregnant and breeding dogs has not been evaluated. Propofol crosses the placenta and, as with other general anesthetic agents, the administration of propofol may be associated with neonatal depression. Propofol has not been evaluated in dogs less than 10 weeks of age (Contraindication, High)
Top reaction signals
Trouble breathing (dyspnea) (1) Loss of appetite (1) Elevated temperature (1) Elevated serum alkaline phosphatase (1) Dysphoria (1) Dry mucous membrane (1) Drooling (1) Disorientation (1)

Identifiers & Packages

Normalized identifiers (NDC/NADA/ANADA) and package metadata from regulator listings.

Identifiers
ANADA: 200793 NADA: 141070 NADA: 141098 NADA: 141303 NDC Package: 11695-2801-1 NDC Package: 11695-7036-1 NDC Package: 13985-740-23 NDC Package: 54771-4944-1 NDC Package: 54771-4944-2 NDC Package: 54771-5206-1 NDC Package: 68504-008-01 NDC Package: 86064-001-20 NDC Package: 86136-136-31 NDC Product: 11695 NDC Product: 13985 NDC Product: 54771 NDC Product: 68504 NDC Product: 86064 NDC Product: 86136
Package NDC Product NDC Form / Route Status
11695-2801-1 11695 -
11695-7036-1 11695 -
13985-740-23 13985 -
54771-4944-1 54771 -
54771-4944-2 54771 -
54771-5206-1 54771 -
68504-008-01 68504 -
86064-001-20 86064 -
86136-136-31 86136 -

Enriched Documents

Documents are tiered by source trust: Official, Clinical, Manufacturer, Marketing.

  • Propovan CF SPL • Structured Product Label • Official
    FDA Structured Product Label from the electronic animal drug product listing directory.
  • Propofol SPL • Structured Product Label • Official
    FDA Structured Product Label from the electronic animal drug product listing directory.
  • PropoFlo 28 SPL • Structured Product Label • Official
    FDA Structured Product Label from the electronic animal drug product listing directory.
  • Rapanofal SPL • Structured Product Label • Official
    FDA Structured Product Label from the electronic animal drug product listing directory.
  • PropoFlo SPL • Structured Product Label • Official
    FDA Structured Product Label from the electronic animal drug product listing directory.
  • FOI Summary oA 200-793 Approved November 18, 2024.pdf • FOI summary • Official • Dec. 2, 2024
    FDA FOI summary for application 200793
  • UCM488658.pdf • FOI summary • Official • April 29, 2022
    FDA FOI summary for application 141070
  • ucm116781.pdf • FOI summary • Official • April 29, 2022
    FDA FOI summary for application 141070
  • UCM355533.pdf • FOI summary • Official • Dec. 18, 2017
    FDA FOI summary for application 141098
  • UCM248263.pdf • FOI summary • Official • Dec. 18, 2017
    FDA FOI summary for application 141098
  • UCM224476.pdf • FOI summary • Official • June 1, 2016
    FDA FOI summary for application 141303

Data Sources & Change Log

Every non-trivial field is expected to include provenance and update timestamps.

Official 46 Clinical 1 Manufacturer 0 Marketing 0
Current Field Facts
  • side_effects: Top reported reactions (openFDA): Death, Vomiting, Lack of efficacy - NOS, Bradycardia, Seizure NOS, Diarrhoea. (Clinical, 2026-04-11)
  • contraindications: Adequate data concerning safe use of propofol in pregnant and breeding cats have not been obtained. Doses may need adjustment for geriatric or debilitated pati… (Official, 2026-04-12)
  • contraindications: Adequate data concerning safe use of propofol in pregnant and breeding cats have not been obtained. Doses may need adjustment for geriatric or debilitated pati… (Official, 2026-04-11)
  • contraindications: Adequate data concerning safe use of propofol in pregnant and breeding cats have not been obtained. Doses may need adjustment for geriatric or debilitated pati… (Official, 2026-02-12)
  • indications: 1. The supplement supports the addition of a new species, cats, to the original approved dog application for the same anesthetic indications.2. The supplement … (Official, 2026-05-05)
  • indications: 1. The supplement supports the addition of a new species, cats, to the original approved dog application for the same anesthetic indications.2. The supplement … (Official, 2026-05-03)
  • indications: 1. The supplement supports the addition of a new species, cats, to the original approved dog application for the same anesthetic indications.2. The supplement … (Official, 2026-05-02)
  • indications: 1. The supplement supports the addition of a new species, cats, to the original approved dog application for the same anesthetic indications.2. The supplement … (Official, 2026-04-29)
  • indications: 1. The supplement supports the addition of a new species, cats, to the original approved dog application for the same anesthetic indications.2. The supplement … (Official, 2026-04-28)
  • indications: 1. The supplement supports the addition of a new species, cats, to the original approved dog application for the same anesthetic indications.2. The supplement … (Official, 2026-04-27)
  • indications: 1. The supplement supports the addition of a new species, cats, to the original approved dog application for the same anesthetic indications.2. The supplement … (Official, 2026-04-26)
  • indications: 1. The supplement supports the addition of a new species, cats, to the original approved dog application for the same anesthetic indications.2. The supplement … (Official, 2026-04-25)
  • indications: 1. The supplement supports the addition of a new species, cats, to the original approved dog application for the same anesthetic indications.2. The supplement … (Official, 2026-04-22)
  • manufacturer_name: Multiple FDA labelers (Official, 2026-05-05)
  • manufacturer_name: Multiple FDA labelers (Official, 2026-05-03)
  • manufacturer_name: Multiple FDA labelers (Official, 2026-05-02)
  • manufacturer_name: Multiple FDA labelers (Official, 2026-04-29)
  • manufacturer_name: Multiple FDA labelers (Official, 2026-04-28)
  • manufacturer_name: Multiple FDA labelers (Official, 2026-04-27)
  • manufacturer_name: Multiple FDA labelers (Official, 2026-04-26)
Recent Revisions
  • side_effects updated 2026-04-12 10:05 by etl_backfill • Backfilled from existing medication fields
  • contraindications updated 2026-04-12 10:05 by etl_backfill • Backfilled from existing medication fields
  • usage updated 2026-04-12 10:05 by etl_backfill • Backfilled from existing medication fields
  • side_effects updated 2026-04-11 10:05 by etl_backfill • Backfilled from existing medication fields
  • contraindications updated 2026-04-11 10:05 by etl_backfill • Backfilled from existing medication fields
  • usage updated 2026-04-11 10:05 by etl_backfill • Backfilled from existing medication fields
  • side_effects updated 2026-02-12 22:44 by etl_backfill • Backfilled from existing medication fields
  • contraindications updated 2026-02-12 22:44 by etl_backfill • Backfilled from existing medication fields
  • usage updated 2026-02-12 22:44 by etl_backfill • Backfilled from existing medication fields

FDA Products & Applications (Animal Drugs @ FDA)

Official sponsor/proprietary-name/application-status records linked by active ingredient.

Product Sponsor Application Status Published
PropofolVet Multidose
RX
Propofol
Injectable emulsion • Intravenous
Label highlights
Official documents
Parnell Technologies Pty. Ltd. ANADA 200-793 Approved Dec 2, 2024
Rapanofal®
RX
Propofol
Liquid (Emulsion) • Intravenous
Label highlights
Official documents
IVAOES, INC. DBA IVAOES ANIMAL HEALTH NADA 141-070 Approved Apr 29, 2022
PropoFlo™ 28 PropoFlo™
RX
Propofol
Liquid (Emulsion) • Intravenous
Label highlights
Official documents
Zoetis Inc. NADA 141-098 Approved Dec 18, 2017
PropoClear™
RX
Propofol
Microemulsion • Intravenous
Label highlights
Official documents
Zoetis Inc. NADA 141-303 Approved Jun 1, 2016

Data source: FDA Animal Drugs @ FDA (public search export).

What It's For (FDA Label Highlights)

Extracted from FDA Animal Drugs @ FDA product labeling. Always confirm details with your veterinarian.

Composition / specifications
10 mg/mL propofol
Dogs
Indication

For induction of anesthesia. For maintenance of general anesthesia by intermittent bolus injections for short procedures. For induction of general anesthesia where maintenance is provided by inhalant anesthetics.

Dosage

For induction of general anesthesia without the use of preanesthetics, the dosage is 7.6 milligrams per kilogram titrated against the response of the patient over 60-90 seconds or until clinical signs show the onset of anesthesia (5.0 to 7.6 mg/kg/min).The use of preanesthetic medication reduces propofol dose requirements. For the maintenance of general anesthesia without the use of preanesthetics, the dosage is 3.2 milligrams per kilogram The use of preanesthetic medication reduces propofol dose requirements. Due to the rapid metabolism of propofol, additional low doses of propofol, similar to those used for maintenance with propofol, may be required to complete the transition to inhalant maintenance anesthesia.

Limitations

FDA page: Open in Animal Drugs @ FDA

Species: Dog, No Use Class Stated Or Implied • Cat, No Use Class Stated Or Implied
Composition / specifications
The drug is a sterile, nonpyrogenic, oil-in-water emulsion containing 10 milligrams of propofol per milliliter.
Cats
Indication
The drug is indicated for use as an anesthetic as follows: As a single injection to provide general anesthesia for short procedures, for induction and maintenance of general anesthesia using incremental doses to effect, and for induction of general anesthesia where maintenance is provided by inhalant anesthetics.
Dosage
The drug is administered by intravenous injection as follows: For induction of general anesthesia without the use of preanesthetics the dosage is 8.0 to 13.2 milligrams per kilogram (3.6 to 6.0 milligrams per pound). For the maintenance of general anesthesia without the use of preanesthetics the dosage is 1.1 to 4.4 milligrams per kilogram (0.5 to 2.0 milligrams per pound). The use of preanesthetic medication reduces propofol dose requirements.
Limitations
Adequate data concerning safe use of propofol in pregnant and breeding cats have not been obtained. Doses may need adjustment for geriatric or debilitated patients. Federal law restricts this drug to use by or on the order of a licensed veterinarian.
Dogs
Indication
The drug is indicated for use as an anesthetic as follows: As a single injection to provide general anesthesia for procedures lasting up to 5 minutes; for induction and maintenance of general anesthesia using incremental doses to effect; for induction of general anesthesia where maintenance is provided by inhalant anesthetics.
Dosage
The drug is administered by intravenous injection as follows: For induction of general anesthesia without the use of preanesthetics the dosage is 5.5 to 7.0 milligrams per kilogram (2.5 to 3.2 milligrams per pound); for the maintenance of general anesthesia without the use of preanesthetics the dosage is 1.1 to 3.3 milligrams per kilogram (0.5 to 1.5 milligrams per pound). The use of preanesthetic medication reduces propofol dose requirements.
Limitations
Adequate data concerning safe use of propofol in pregnant and breeding dogs have not been obtained. Doses may need adjustment for geriatric or debilitated patients.

FDA page: Open in Animal Drugs @ FDA

Species: Dog, No Use Class Stated Or Implied
Composition / specifications
Each mL contains 10 mg propofol.
Dogs
Indication
For induction of anesthesia. For maintenance of general anesthesia for up to 20 minutes. For induction of general anesthesia where maintenance is provided by inhalant anesthetics.
Dosage
For induction of general anesthesia without the use of preanesthetics, the dosage is 5.5 to 7.6 milligrams per kilogram (2.5 to 3.2 milligrams per pound)The use of preanesthetic medication reduces propofol dose requirements. For the maintenance of general anesthesia without the use of preanesthetics, the dosage is 2.2 to 3.2 milligrams per kilogram (0.5 to 1.5 milligrams per pound. The use of preanesthetic medication reduces propofol dose requirements.
Limitations
Federal (USA) law restricts this drug to use by or on the order of a licensed veterinarian. Administer by intravenous injection only. Rapid bolus administration (induction or maintenance) or accidental overdosage of propofol may cause undesirable cardiorespiratory depression including hypotension and oxygen desaturation. Respiratory arrest (apnea) could occur. When using propofol, dogs should be continuously monitored and facilities for the maintenance of a patent airway, artificial ventilation, and oxygen supplementation must be immediately available. The use of propofol in pregnant and breeding dogs has not been evaluated. Propofol crosses the placenta and, as with other general anesthetic agents, the administration of propofol may be associated with neonatal depression. Propofol has not been evaluated in dogs less than 10 weeks of age

FDA page: Open in Animal Drugs @ FDA

Species: Dog, No Use Class Stated Or Implied • Cat, No Use Class Stated Or Implied
Composition / specifications
Each mL contains 10 mg propofol.
Dogs
Indication
For the induction and maintenance of anesthesia and for induction followed by maintenance with an inhalant anesthetic.
Dosage
Induction of General Anesthesia in Dogs: Induction dose guidelines are 4.0 to 6.5 mg/kg in dogs that do not receive a preanesthetic, and 1.4 to 6.5 mg/kg in dogs that receive a preanesthetic. The mean PROPOCLEAR induction dose is reduced by 20 to 30% for dogs that receive a preanesthetic (dose sparing effect). Anesthesia is usually observed within 60 seconds after the end of the induction dose administration. Duration of anesthesia following the recommended induction dose is approximately 4 minutes without a preanesthetic and 4 to 11 minutes with a preanesthetic. Individual anesthesia times may vary. Maintenance of General Anesthesia in Dogs: Anesthesia can be maintained by administration of PROPOCLEAR using intermittent IV injections. For dogs, the duration of anesthesia following a PROPOCLEAR maintenance dose is approximately 3 to 5 minutes. Clinical response may vary, and is determined by the dose, the rate of administration, and the frequency of maintenance injections. The maintenance dose and frequency should be based on the patient’s response. Sighthounds may need lower maintenance doses of PROPOCLEAR, and the time between maintenance dose administration and for recovery may be longer.
Limitations
Federal law restricts this drug to use by or on the order of a licensed veterinarian. When using propofol, patients should be continuously monitored and facilities for the maintenance of a patient airway, artificial ventilation, and oxygen supplementation must be immediately available.
Cats
Indication
For the induction and maintenance of anesthesia and for induction followed by maintenance with an inhalant anesthetic.
Dosage
Induction of General Anesthesia in Cats: Induction dose guidelines are 4.1 to 8.0 mg/kg for cats that do not receive a preanesthetic, and 2.7 to 8.0 mg/kg for cats that receive a preanesthetic. The PROPOCLEAR induction dose is reduced by 16 to 24% for cats that receive a preanesthetic (dose sparing effect). Anesthesia is usually observed within 60 seconds after the end of the induction dose administration. Duration of anesthesia following the recommended induction dose is approximately 3 minutes without a preanesthetic and 3 to 6 minutes with a preanesthetic. Full standing recovery occurs within approximately 30 minutes in cats. Individual anesthesia times vary. The actual induction dose should be based on patient response. Maintenance of General Anesthesia in Cats: Anesthesia can be maintained by administration of PROPOCLEAR using intermittent IV injections. For cats, the duration of anesthesia following each PROPOCLEAR maintenance dose is approximately 3 to 5 minutes. Clinical response may vary, and is determined by the dose, rate of administration and frequency of maintenance injections. PROPOCLEAR maintenance dose sparing is greater in cats that receive a preanesthetic. The maintenance dose and frequency should be based on the patient’s response.
Limitations
Federal law restricts this drug to use by or on the order of a licensed veterinarian. When using propofol, patients should be continuously monitored and facilities for the maintenance of a patient airway, artificial ventilation, and oxygen supplementation must be immediately available.

FDA page: Open in Animal Drugs @ FDA

Usage

The drug is indicated for use as an anesthetic as follows: As a single injection to provide general anesthesia for short procedures, for induction and maintenance of general anesthesia using incremental doses to effect, and for induction of general anesthesia where maintenance is provided by inhalant anesthetics. The drug is indicated for use as an anesthetic as follows: As a single injection to provide general anesthesia for procedures lasting up to 5 minutes; for induction and maintenance of general anesthesia using incremental doses to effect; for induction of general anesthesia where maintenance is provided by inhalant anesthetics. For induction of anesthesia. For maintenance of general anesthesia for up to 20 minutes. For induction of general anesthesia where maintenance is provided by inhalant anesthetics.

Source: FDA Animal Drugs @ FDA • Reference

Contraindications

Adequate data concerning safe use of propofol in pregnant and breeding cats have not been obtained. Doses may need adjustment for geriatric or debilitated patients. Federal law restricts this drug to use by or on the order of a licensed veterinarian. Adequate data concerning safe use of propofol in pregnant and breeding dogs have not been obtained. Doses may need adjustment for geriatric or debilitated patients. Federal (USA) law restricts this drug to use by or on the order of a licensed veterinarian. Administer by intravenous injection only. Rapid bolus administration (induction or maintenance) or accidental overdosage of propofol may cause undesirable cardiorespiratory depression including hypotension and oxygen desaturation. Respiratory arrest (apnea) could occur. When using propofol, dogs should be continuously monitored and facilities for the maintenance of a patent airway, artificial ventilation, and oxygen supplementation must be immediately available. The use of propofol in pregnant and breeding dogs has not been evaluated. Propofol crosses the placenta and, as with other general anesthetic agents, the administration of propofol may be associated with neonatal depression. Propofol has not been evaluated in dogs less than 10 weeks of age

Top Reported Reactions (openFDA)

De-duplicated reaction terms grouped by body system from FDA openFDA reports (not verified; does not prove causation).

Digestive
Loss of appetite (1) • Dog Drooling (1) • Dog Diarrhea (1) • Dog Decreased appetite (1) • Dog Bloody diarrhoea (1) • Cat

Showing top 5 for Digestive.

Skin & allergy
Application site hair loss (1) • Cat

Showing top 5 for Skin & allergy.

Behavior
Behavioral disorder (1) • Cat

Showing top 5 for Behavior.

Other
Trouble breathing (1) • Dog Elevated temperature (1) • Cat Elevated serum alkaline phosphatase (1) • Dog Elevated alanine aminotransferase (1) • Cat Dysphoria (1) • Cat
Show more (20)
Dry mucous membrane (1) • Cat Disorientation (1) • Cat Decreased heart rate (1) • Dog Decreased haematocrit (1) • Cat Decreased drinking (1) • Dog Decreased blood urea nitrogen (BUN) or creatinine (1) • Cat Death by euthanasia (1) • Cat Death (1) • Cat Deafness (1) • Dog Crust (1) • Dog Cardiac arrest (1) • Cat Burn (1) • Dog Breathing difficulty (1) • Cat Bladder distension (1) • Cat Bacterial skin infection NOS (1) • Dog Arthritis (1) • Cat Administration error NOS (1) • Cat Acid-base disorder (1) • Dog Abnormal radiograph finding (1) • Dog Abnormal electrocardiogram (1) • Dog

Showing top 5 for Other.

Data source: FDA openFDA Animal & Veterinary adverse event reports.

Adverse Event Case Summaries (openFDA)

These are individual FDA adverse event reports. They are unverified and do not prove the medication caused the reaction.

Dog, Siberian Husky, Male, 9 year, 21.682 kilogram • Drug: MSK, Unassigned, Intravenous • Reactions: Injection site lesion, Crust, Injection site ulcer, Injection site erythema, Injection site discharge NOS • Outcome: Ongoing

  • Report ID: USA-USFDACVM-2025-US-075214
  • Serious AE: Yes
  • Treated For AE: Yes
  • Sex: Male
  • Age: 9.00 Year
  • Weight: 21.682 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Intravenous
  • Form: Unassigned
Reactions Reported:
Injection site lesion Crust Injection site ulcer Injection site erythema Injection site discharge NOS
Outcomes: Ongoing

Dog, Bulldog - French, Male, 8 year, 12.428 kilogram • Drug: MSK, Unassigned, Intravenous • Reactions: Decreased appetite, Decreased drinking, Tiredness (lethargy), Panting, Tense muscles… • Outcome: Recovered/Normal

  • Report ID: USA-USFDACVM-2025-US-074194
  • Serious AE: Yes
  • Treated For AE: Yes
  • Sex: Male
  • Age: 8.00 Year
  • Weight: 12.428 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Intravenous
  • Form: Unassigned
Reactions Reported:
Decreased appetite Decreased drinking Tiredness (lethargy) Panting Tense muscles Seizure NOS Inappropriate defecation Inappropriate urination Unable to walk Proprioception deficit Generalised weakness Lameness Limb non-weight bearing Abnormal radiograph finding Medication error NOS
Outcomes: Recovered/Normal

Cat, Domestic Shorthair, Female, 6 month, 3.084 kilogram • Drug: MSK, Intravenous, Dose: 2 mL per unknown • Reactions: Elevated temperature, Breathing difficulty, Quiet • Outcome: Ongoing

  • Report ID: USA-USFDACVM-2025-US-074179
  • Serious AE: Yes
  • Treated For AE: Yes
  • Sex: Female
  • Age: 6.00 Month
  • Weight: 3.084 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Intravenous
  • Dose: 2 mL per unknown
Reactions Reported:
Elevated temperature Breathing difficulty Quiet
Outcomes: Ongoing

Cat, Maine Coon, Male, 13 year, 6.58 kilogram • Drug: MSK, Unknown • Reactions: Twitching, Focal seizure, Death, Tiredness (lethargy) • Outcome: Died

  • Report ID: USA-USFDACVM-2025-US-074994
  • Serious AE: Yes
  • Treated For AE: No
  • Sex: Male
  • Age: 13.00 Year
  • Weight: 6.580 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Unknown
Reactions Reported:
Twitching Focal seizure Death Tiredness (lethargy)
Outcomes: Died

Cat, Domestic Shorthair, Male, 12 year, 5.44 kilogram • Drug: MSK, Unknown • Reactions: Application site hair loss, Hair loss NOS • Outcome: Outcome Unknown

  • Report ID: USA-USFDACVM-2025-US-073492
  • Serious AE: No
  • Treated For AE: No
  • Sex: Male
  • Age: 12.00 Year
  • Weight: 5.440 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Unknown
Reactions Reported:
Application site hair loss Hair loss NOS
Outcomes: Outcome Unknown

Cat, Maine Coon, Male, 7 month, 6.1 kilogram • Drug: MSK, Unknown, Dose: 2 mL per animal • Reactions: Not eating, Not sleeping, Staring, Falling • Outcome: Recovered/Normal

  • Report ID: USA-USFDACVM-2025-US-073842
  • Serious AE: No
  • Treated For AE: No
  • Sex: Male
  • Age: 7.00 Month
  • Weight: 6.100 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Unknown
  • Dose: 2 mL per animal
Reactions Reported:
Not eating Not sleeping Staring Falling
Outcomes: Recovered/Normal

Dog, ['Terrier (unspecified)', 'Whippet'], Female, 8 month, 8.7 kilogram • Drug: MSK, Suspension, Unknown • Reactions: Trembling, Panting, Drooling, Decreased heart rate • Outcome: Ongoing

  • Report ID: USA-USFDACVM-2025-US-073498
  • Serious AE: Yes
  • Treated For AE: Yes
  • Sex: Female
  • Age: 8.00 Month
  • Weight: 8.700 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Unknown
  • Form: Suspension
Reactions Reported:
Trembling Panting Drooling Decreased heart rate
Outcomes: Ongoing

Dog, Shepherd Dog - Australian, Male, 7 month, 11.6 kilogram • Drug: MSK, Emulsion, Intravenous, Dose: 5.80 mL per animal • Reactions: Seizure NOS, Underdose • Outcome: Ongoing

  • Report ID: USA-USFDACVM-2025-US-071639
  • Serious AE: Yes
  • Treated For AE: Yes
  • Sex: Male
  • Age: 7.00 Month
  • Weight: 11.600 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Intravenous
  • Form: Emulsion
  • Dose: 5.80 mL per animal
Reactions Reported:
Seizure NOS Underdose
Outcomes: Ongoing

Data source: FDA openFDA Animal & Veterinary adverse event reports.

Overdose Information

No approved overdose-management text is linked yet. If overdose is suspected, contact a veterinarian or emergency clinic immediately.

Storage & Handling

No approved storage guidance is linked yet for this ingredient. Use manufacturer packaging and veterinary guidance for handling/storage.

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Let others know your experience or advice regarding this medication.

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