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Roxee Medication Guide
Medication reference facts with explicit FDA-approval, off-label, source-limited, and safety context. Roxee does not sell, prescribe, or dispense medications.
Veterinary professional?
These are the reference facts Roxee uses on browse cards and quick facts.
Sponsor, product, and application records imported from Animal Drugs @ FDA.
openFDA reaction terms and case summaries are supporting evidence, not proof of causality.
Drug type: Generic ingredient • Generic profile • No FDA branded products linked
Species: Both
Manufacturer: Multiple FDA sponsors
Merged from the current Roxee medication system with field-level provenance, freshness, and completeness tracking.
For the removal and control of infections from the following mature parasites: Large strongyles ( Strongylus vulgaris, Strongylus edentatus, Strongylus equinus ), small strongyles, pinworms ( Oxyuris equi ) and large roundworms ( Parascaris ). For the removal and control of large roundworm ( Ascaris suum ) infections. Aid in the prevention of migration and establishment of large roundworm ( Ascaris suum ) infections; aid in the prevention of establishment of nodular worm ( Oesophagostomum ) infections. Species commonly shown: Both, Dog, Horse, Not For Meat Production.
For the removal and control of infections from the following mature parasites: Large strongyles ( Strongylus vulgaris , Strongylus edentatus , Strongylus equinus ), small strongyles, pinworms ( Oxyuris equi ) and large roundworms ( Parascaris ). For the removal and control of large roundworm ( Ascaris suum ) infections. Aid in the prevention of migration and establishment of large roundworm ( Ascaris suum ) infections; aid in the prevention of establishment of nodular worm ( Oesophagostomum ) infections.
It is recommended that severely debilitated animals not be treated with this drug. Do not use in horses intended for food. Feed for 3 days as sole ration in a Type C feed. Consult veterinarian before using in severely debilitated animals. Do not mix in Type B or Type C medicated feeds containing bentonite. Feed continuously as the sole ration in a Type C feed. Consult veterinarian before using in severely debilitated animals. Do not mix in Type B or Type C medicated feeds containing bentonite.
Top reported reactions (openFDA): Lack of efficacy (endoparasite) - heartworm, Vomiting, Lack of efficacy (endoparasite) - hookworm, INEFFECTIVE, HEARTWORM LARVAE, Diarrhoea, INEFFECTIVE, HOOKS.
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Used for:
Prevention of Strongylus vulgaris larval infections; control of adult large strongyles ( S. vulgaris , S. edentates ); adult and 4th stage larvae small strongyles ( Cyathostomum species, Cylicocyclus species., Cylicostep...
Dosing note:
Exact dosing depends on your pet's species, weight, and health status. Use your veterinarian's instructions for the exact dose and schedule.
What to watch for:
When to call the vet:
What to tell or ask your vet today:
A source-aware map of what to know, what is uncertain, and what to verify with your veterinarian.
Roxee has limited cited overview evidence for Pyrantel; use the official documents and your veterinarian's instructions for product-specific decisions.
32 tracked reaction signals; 32 reported cases; 28 serious reports; 2 species groups. These are reporting and label-derived signals for interpretation with a veterinarian.
Adverse-event reports help form a watch list, but they do not prove the medication caused the reaction and they are not a risk ranking between medications.
Official labels, package inserts, and reviewed summaries carry more weight than isolated reports.
Case reports and openFDA terms are useful for pattern awareness, but they are incomplete, can include multiple exposures, and do not estimate an individual pet's probability of harm.
Loss of appetite (1 reports), Decreased red blood cell count (1 reports), Decreased percentage of reticulocytes (1 reports), Decreased appetite (1 reports), Decreased activity (1 reports)
Digestive (2), Neurologic (2), Behavior (2), Other (26)
Cat (22 reports), Dog (10 reports)
Domestic Shorthair (3), Terrier - Yorkshire (1), Retriever - Labrador (1), ['Siberian Husky', 'Shepherd Dog - German'] (1). These are report metadata, not proof that a breed is at higher risk.
Verify whether Pyrantel fits the pet's species, current diagnosis, age, weight, organ status, pregnancy/lactation status, and concurrent medications.
Separate label-backed warnings from adverse-event reports and owner observations before changing the plan.
It is recommended that severely debilitated animals not be treated with this drug, Do not use in horses intended for food, Feed for 3 days as sole ration in a Type C feed, Consult veterinarian before using in severely debilitated animals, Do not mix in Type B or Type C medicated feeds containing bentonite
Repeated vomiting or diarrhea. Severe lethargy (hard to wake, very low energy). Collapse or fainting.
Review status / Updated / Sources
Review status: Clinical reviewer not listed
Updated: April 15, 2026, 10:04 AM UTC
Side effects to monitor:
Most reported reactions:
Emergency warning signs:
Source-backed clinical checkpoints for quick review.
Official label facts first, then secondary summaries. Marketing content is separated below.
It is recommended that severely debilitated animals not be treated with this drug. Do not use in horses intended for food. Feed for 3 days as sole ration in a Type C feed. Consult veterinarian before using in severely debilitated animals. Do not mix in Type B or Type C medicated feeds containing bentonite. Feed continuously as the sole ration in a Type C feed. Consult veterinarian before using in severely debilitated animals. Do not mix in Type B or Type C medicated feeds containing bentonite.
Snapshot first, detailed rows second. This section summarizes signal data and is not a diagnosis.
Filter stored openFDA reports by pet and report attributes. Counts describe reports in this data set, not risk.
Received 2026-02-16 · MSK · MSK
Received 2025-12-02 · MSK · MSK
Received 2025-11-03 · MSK · MSK
Tap or hover a reaction to see what it means in plain language.
| Reaction | Body system | Cases | Species | Serious cases |
|---|---|---|---|---|
| Digestive | 1 | Cat | 1 | |
| Other | 1 | Dog | 1 | |
| Other | 1 | Dog | 1 | |
| Digestive | 1 | Cat | 1 | |
| Other | 1 | Cat | 1 | |
| Other | 1 | Dog | 1 | |
| Other | 1 | Cat | 1 | |
| Other | 1 | Dog | 1 |
Species coverage: Cat (22) Dog (10)
| Reaction | Body system | Species | Seriousness | Frequency | Reports |
|---|---|---|---|---|---|
| Neurologic | Cat | Non-serious | - | 1 | |
| Digestive | Cat | Serious | - | 1 | |
| Other | Dog | Serious | - | 1 | |
| Other | Dog | Serious | - | 1 | |
| Digestive | Cat | Serious | - | 1 | |
| Other | Cat | Serious | - | 1 | |
| Other | Dog | Serious | - | 1 | |
| Other | Cat | Serious | - | 1 | |
| Other | Cat | Non-serious | - | 1 | |
| Other | Dog | Serious | - | 1 | |
| Other | Dog | Serious | - | 1 | |
| Other | Dog | Serious | - | 1 | |
| Other | Cat | Serious | - | 1 | |
| Other | Dog | Serious | - | 1 | |
| Neurologic | Cat | Serious | - | 1 | |
| Other | Cat | Serious | - | 1 | |
| Other | Cat | Serious | - | 1 | |
| Other | Cat | Serious | - | 1 | |
| Other | Cat | Serious | - | 1 | |
| Other | Dog | Serious | - | 1 | |
| Behavior | Cat | Serious | - | 1 | |
| Behavior | Cat | Serious | - | 1 | |
| Other | Cat | Serious | - | 1 | |
| Other | Cat | Serious | - | 1 | |
| Other | Dog | Serious | - | 1 | |
| Other | Cat | Non-serious | - | 1 | |
| Other | Cat | Non-serious | - | 1 | |
| Other | Cat | Serious | - | 1 | |
| Other | Cat | Serious | - | 1 | |
| Other | Cat | Serious | - | 1 | |
| Other | Cat | Serious | - | 1 | |
| Other | Dog | Serious | - | 1 |
The most useful source links appear first; full previews and metadata stay in the veterinary/professional layer.
Use original documents to confirm product-specific warnings, ingredients, and handling details with your veterinarian.
Full source previews and metadata remain in the veterinary/professional layer.
SPL · SPL
Rendered from Roxee's cached FDA SPL package contents for on-page reading. Use Open original for the raw FDA ZIP/XML source.
Administer either as a top-dress (not to exceed 20,000 grams per ton) or mixed in the horse's daily grain ration (not to exceed 1,200 grams per ton) during the time that the animal is at risk of exposure to internal parasites. Do not use in horses intended for human consumption. Consult your veterinarian before using in severely debilitated animals and for assistance in the diagnosis, treatment, and control of parasitism. Do not mix in Type B or Type C medicated feeds containing bentonite.
SPL · SPL
Rendered from Roxee's cached FDA SPL package contents for on-page reading. Use Open original for the raw FDA ZIP/XML source.
For removal and control of infections from the following mature parasites: large strongyles (Strongylus vulgaris, S. edentatus, S. equinus); small strongyles; pinworms (Oxyuris equi); and large roundworms (Parascaris equorum).
Administer as single dose by depositing paste on dorsum of the tongue using the dose syringe. Equivalent of 3 milligrams pyrantel base per pound of body weight.
SPL · SPL
Rendered from Roxee's cached FDA SPL package contents for on-page reading. Use Open original for the raw FDA ZIP/XML source.
For removal and control of infections from the following mature parasites: large strongyles (Strongylus vulgaris, S. edentatus, S. equinus); small strongyles; pinworms (Oxyuris equi); and large roundworms (Parascaris equorum).
Administer as single dose by depositing paste on dorsum of the tongue using the dose syringe. Equivalent of 3 milligrams pyrantel base per pound of body weight.
SPL · SPL
Rendered from Roxee's cached FDA SPL package contents for on-page reading. Use Open original for the raw FDA ZIP/XML source.
For removal of ascarids (Toxocara canis; Toxascaris leonina), and hookworms (Ancylostoma caninum; Uncinaria stenocephala) in dogs and puppies. To prevent reinfection of Toxocara canis in puppies and adult dogs and in lactating bitches after whelping
22.7 mg tablet in puppies and small dogs
For the removal of large roundworms (Ascarids) and hookworms, give 1 tablet for each 10 lb of body weight. Dosage is designed to provide at least 2.27 mg per pound body weight for dogs weighing over 5 lb, and at least 4.54 mg per pound of body weight for dogs weighing 5 lb or less. For dogs weighing more than 10 lb, tablets may be broken in half to provide ½ tablet for each additional 5 lb of body weight.
113.5 mg tablet in large dogs
For the removal of large roundworms (Ascarids) and hookworms in adult dogs or young dogs weighing more than 25 lb, administer tablets according to the weight of the animal.
Administer to puppies at 2, 3, 4, 6, 8, and 10 weeks of age. Administer to lactating bitches 2 to 3 weeks after whelping. Retreatment of adult dogs may be necessary at monthly intervals as determined by laboratory fecal examinations. Consult your veterinarian for assistance in the diagnosis, treatment, and control of parasitism
SPL · SPL
Rendered from Roxee's cached FDA SPL package contents for on-page reading. Use Open original for the raw FDA ZIP/XML source.
SPL · SPL
Rendered from Roxee's cached FDA SPL package contents for on-page reading. Use Open original for the raw FDA ZIP/XML source.
SPL · SPL
Rendered from Roxee's cached FDA SPL package contents for on-page reading. Use Open original for the raw FDA ZIP/XML source.
SPL · SPL
Rendered from Roxee's cached FDA SPL package contents for on-page reading. Use Open original for the raw FDA ZIP/XML source.
SPL · SPL
Rendered from Roxee's cached FDA SPL package contents for on-page reading. Use Open original for the raw FDA ZIP/XML source.
SPL · SPL
Rendered from Roxee's cached FDA SPL package contents for on-page reading. Use Open original for the raw FDA ZIP/XML source.
SPL · SPL
Rendered from Roxee's cached FDA SPL package contents for on-page reading. Use Open original for the raw FDA ZIP/XML source.
SPL · SPL
Rendered from Roxee's cached FDA SPL package contents for on-page reading. Use Open original for the raw FDA ZIP/XML source.
SPL · SPL
Rendered from Roxee's cached FDA SPL package contents for on-page reading. Use Open original for the raw FDA ZIP/XML source.
SPL · SPL
Rendered from Roxee's cached FDA SPL package contents for on-page reading. Use Open original for the raw FDA ZIP/XML source.
SPL · SPL
Rendered from Roxee's cached FDA SPL package contents for on-page reading. Use Open original for the raw FDA ZIP/XML source.
SPL · SPL
Rendered from Roxee's cached FDA SPL package contents for on-page reading. Use Open original for the raw FDA ZIP/XML source.
SPL · SPL
Rendered from Roxee's cached FDA SPL package contents for on-page reading. Use Open original for the raw FDA ZIP/XML source.
SPL · SPL
Rendered from Roxee's cached FDA SPL package contents for on-page reading. Use Open original for the raw FDA ZIP/XML source.
SPL · SPL
Rendered from Roxee's cached FDA SPL package contents for on-page reading. Use Open original for the raw FDA ZIP/XML source.
SPL · SPL
Rendered from Roxee's cached FDA SPL package contents for on-page reading. Use Open original for the raw FDA ZIP/XML source.
SPL · SPL
Rendered from Roxee's cached FDA SPL package contents for on-page reading. Use Open original for the raw FDA ZIP/XML source.
FOI · FOI
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Canonical medication sections are above. This legacy block remains available for deeper cross-reference without cluttering the primary workflow.
Quick facts and links to official labeling and safety signals.
Global Pet owner/Vet mode is controlled in the header. This section avoids duplicate in-page persona tabs.
Normalized identifiers (NDC/NADA/ANADA) and package metadata from regulator listings.
| Package NDC | Product NDC | Form / Route | Status |
|---|---|---|---|
| 0010-4012-01 | 0010 | - | |
| 0010-4012-02 | 0010 | - | |
| 0010-4012-03 | 0010 | - | |
| 0010-4012-04 | 0010 | - | |
| 0010-4013-01 | 0010 | - | |
| 0010-4013-02 | 0010 | - | |
| 0010-4013-03 | 0010 | - | |
| 0010-4013-04 | 0010 | - | |
| 0010-4014-01 | 0010 | - | |
| 0010-4014-02 | 0010 | - | |
| 0010-4014-03 | 0010 | - | |
| 0010-4014-04 | 0010 | - | |
| 0010-4260-01 | 0010 | - | |
| 0010-4260-02 | 0010 | - | |
| 0010-4260-03 | 0010 | - | |
| 0010-4261-01 | 0010 | - | |
| 0010-4261-02 | 0010 | - | |
| 0010-4261-03 | 0010 | - | |
| 0010-4262-01 | 0010 | - | |
| 0010-4262-02 | 0010 | - |
Documents are tiered by source trust: Official, Clinical, Manufacturer, Marketing.
Every non-trivial field is expected to include provenance and update timestamps.
Official sponsor/proprietary-name/application-status records linked by active ingredient.
| Product | Sponsor | Application | Status | Published |
|---|---|---|---|---|
|
Strongid® 48
OTC
Pyrantel Tartrate
Top Dressing In Feed
• Oral
|
Zoetis Inc. | NADA 140-819 | Approved | Nov 7, 2023 |
|
Exodus™ Paste Exodus® Multi Dose
OTC
Pyrantel Pamoate
Paste
• Oral
|
Bimeda Animal Health Ltd. | ANADA 200-350 | Approved | May 29, 2020 |
|
WormX®
OTC
Pyrantel Pamoate
Flavored Tablets
• Oral
|
Sergeant’s Pet Care Products Inc. | ANADA 200-600 | W | Apr 1, 2019 |
|
Pyrantel Pamoate Paste
OTC
Pyrantel Pamoate
Paste
• Oral
|
Farnam Companies, Inc. | ANADA 200-342 | Approved | Dec 27, 2017 |
|
Anthelban V
RX/OTC
Pyrantel Pamoate
Liquid (Suspension)
• Oral
|
Elanco US Inc. | ANADA 200-246 | Approved | Dec 19, 2017 |
|
Liqui-Vict 2X™
OTC
Pyrantel Pamoate
Liquid (Suspension)
• Oral
|
Happy Jack, Inc. | ANADA 200-007 | Approved | Dec 19, 2017 |
|
Pyrantel Pamoate Suspension-2.27mg Pyrantel Pamoate Suspension-4.54mg Pyrantel Pamoate Suspension
OTC
Pyrantel Pamoate
Liquid (Suspension)
• Oral
|
Cronus Pharma Specialities India Private Ltd. | ANADA 200-248 | Approved | Jul 19, 2017 |
|
Dog Wormer Tablets
OTC
Pyrantel Pamoate
Tablet
• Oral
|
Farnam Companies, Inc. | NADA 101-331 | Approved | Jul 12, 2017 |
|
Evict®
OTC
Pyrantel Pamoate
Liquid (Suspension)
• Oral
|
Pegasus Laboratories, Inc. | ANADA 200-028 | W | Jul 11, 2017 |
|
Continuex™
OTC
Pyrantel Tartrate
Top Dressing In Feed
• Oral
|
Farnam Companies, Inc. | ANADA 200-282 | Approved | Jun 1, 2016 |
|
Dog Wormer Chewable Tablets D-Worm™ Adams™
OTC
Pyrantel Pamoate
Tablet (Chewable)
• Oral
|
Farnam Companies, Inc. | NADA 139-191 | Approved | Jun 1, 2016 |
|
Primex®
OTC
Pyrantel Pamoate
Liquid (Suspension)
• Oral
|
First Priority, Inc. | ANADA 200-445 | Approved | Jun 1, 2016 |
|
Primex® Canine Primex® 2-X
OTC
Pyrantel Pamoate
Liquid (Suspension)
• Oral
|
First Priority, Inc. | ANADA 200-352 | Approved | Jun 1, 2016 |
|
Primex™ Equine
RX
Pyrantel Pamoate
Liquid (Suspension)
• Oral
|
First Priority, Inc. | ANADA 200-353 | Approved | Jun 1, 2016 |
|
Pyrantel Pamoate Chewable Tablets
OTC
Pyrantel Pamoate
Tablet (Chewable)
• Oral
|
Virbac AH, Inc. | ANADA 200-281 | Approved | Jun 1, 2016 |
Data source: FDA Animal Drugs @ FDA (public search export).
Extracted from FDA Animal Drugs @ FDA product labeling. Always confirm details with your veterinarian.
Administer either as a top-dress (not to exceed 20,000 grams per ton) or mixed in the horse's daily grain ration (not to exceed 1,200 grams per ton) during the time that the animal is at risk of exposure to internal parasites. Do not use in horses intended for human consumption. Consult your veterinarian before using in severely debilitated animals and for assistance in the diagnosis, treatment, and control of parasitism. Do not mix in Type B or Type C medicated feeds containing bentonite.
FDA page: Open in Animal Drugs @ FDA
For removal and control of infections from the following mature parasites: large strongyles (Strongylus vulgaris, S. edentatus, S. equinus); small strongyles; pinworms (Oxyuris equi); and large roundworms (Parascaris equorum).
Administer as single dose by depositing paste on dorsum of the tongue using the dose syringe. Equivalent of 3 milligrams pyrantel base per pound of body weight.
FDA page: Open in Animal Drugs @ FDA
For removal of ascarids (Toxocara canis; Toxascaris leonina), and hookworms (Ancylostoma caninum; Uncinaria stenocephala) in dogs and puppies. To prevent reinfection of Toxocara canis in puppies and adult dogs and in lactating bitches after whelping
22.7 mg tablet in puppies and small dogs
For the removal of large roundworms (Ascarids) and hookworms, give 1 tablet for each 10 lb of body weight. Dosage is designed to provide at least 2.27 mg per pound body weight for dogs weighing over 5 lb, and at least 4.54 mg per pound of body weight for dogs weighing 5 lb or less. For dogs weighing more than 10 lb, tablets may be broken in half to provide ½ tablet for each additional 5 lb of body weight.
113.5 mg tablet in large dogs
For the removal of large roundworms (Ascarids) and hookworms in adult dogs or young dogs weighing more than 25 lb, administer tablets according to the weight of the animal.
Administer to puppies at 2, 3, 4, 6, 8, and 10 weeks of age. Administer to lactating bitches 2 to 3 weeks after whelping. Retreatment of adult dogs may be necessary at monthly intervals as determined by laboratory fecal examinations. Consult your veterinarian for assistance in the diagnosis, treatment, and control of parasitism
FDA page: Open in Animal Drugs @ FDA
FDA page: Open in Animal Drugs @ FDA
FDA page: Open in Animal Drugs @ FDA
FDA page: Open in Animal Drugs @ FDA
FDA page: Open in Animal Drugs @ FDA
FDA page: Open in Animal Drugs @ FDA
FDA page: Open in Animal Drugs @ FDA
FDA page: Open in Animal Drugs @ FDA
FDA page: Open in Animal Drugs @ FDA
FDA page: Open in Animal Drugs @ FDA
FDA page: Open in Animal Drugs @ FDA
FDA page: Open in Animal Drugs @ FDA
FDA page: Open in Animal Drugs @ FDA
For the removal and control of infections from the following mature parasites: Large strongyles ( Strongylus vulgaris , Strongylus edentatus , Strongylus equinus ), small strongyles, pinworms ( Oxyuris equi ) and large roundworms ( Parascaris ). For the removal and control of large roundworm ( Ascaris suum ) infections. Aid in the prevention of migration and establishment of large roundworm ( Ascaris suum ) infections; aid in the prevention of establishment of nodular worm ( Oesophagostomum ) infections.
Source: FDA Animal Drugs @ FDA • Reference
It is recommended that severely debilitated animals not be treated with this drug. Do not use in horses intended for food. Feed for 3 days as sole ration in a Type C feed. Consult veterinarian before using in severely debilitated animals. Do not mix in Type B or Type C medicated feeds containing bentonite. Feed continuously as the sole ration in a Type C feed. Consult veterinarian before using in severely debilitated animals. Do not mix in Type B or Type C medicated feeds containing bentonite.
De-duplicated reaction terms grouped by body system from FDA openFDA reports (not verified; does not prove causation).
Showing top 5 for Digestive.
Showing top 5 for Neurologic.
Showing top 5 for Behavior.
Showing top 5 for Other.
Data source: FDA openFDA Animal & Veterinary adverse event reports.
These are individual FDA adverse event reports. They are unverified and do not prove the medication caused the reaction.
Dog, Terrier - Yorkshire, Male, 3 year, 6.622 kilogram • Drug: MSK, Unassigned, Unknown • Reactions: Vomiting, Tiredness (lethargy), Loose bowel • Outcome: Ongoing
Dog, Retriever - Labrador, Female, 5 year, 36.73 kilogram • Drug: MSK, Unknown • Reactions: Lack of efficacy (endoparasite) - hookworm • Outcome: Outcome Unknown
Dog, ['Siberian Husky', 'Shepherd Dog - German'], Male, 9 year, 41.277 kilogram • Drug: MSK, Unknown • Reactions: Other abnormal test result NOS, Lack of efficacy (endoparasite) - heartworm, Tiredness (lethargy), Death by euthanasia, Blood in urine… • Outcome: Euthanized
Cat, Domestic Shorthair, Male, 9 year, 7.1 kilogram • Drug: MSK, Unknown • Reactions: Found dead • Outcome: Died
Cat, Domestic Shorthair, Male, 6 month, 1.8 kilogram • Drug: MSK, Unknown • Reactions: Decreased appetite, Listless, Dehydration, Not himself/herself, Stumbling gait… • Outcome: Ongoing
Cat, Siamese, Male, 1 year, 4.763 kilogram • Drug: MSK, Unassigned, Unknown • Reactions: Anaphylaxis, Vomiting, Bloody stool, Tiredness (lethargy), Hypothermia… • Outcome: Ongoing
Cat, Domestic Shorthair, Male, 4.318 kilogram • Drug: MSK, Liquid, Oral • Reactions: Crying, Unsteady walking (ataxia), Dullness, Dehydration, Intentional misuse • Outcome: Ongoing
Dog, ['Cattle Dog - Australian (blue heeler, red heeler, Queensland cattledog)', 'Dog (unknown)'], Female, 12 week, 7.98 kilogram • Drug: MSK, Unknown • Reactions: Lack of efficacy (endoparasite) - whipworm, Lack of efficacy (endoparasite) - roundworm NOS • Outcome: Outcome Unknown
Data source: FDA openFDA Animal & Veterinary adverse event reports.
No approved overdose-management text is linked yet. If overdose is suspected, contact a veterinarian or emergency clinic immediately.
No approved storage guidance is linked yet for this ingredient. Use manufacturer packaging and veterinary guidance for handling/storage.
Let others know your experience or advice regarding this medication.
This medication has not been reviewed by a veterinarian yet.