Skip to main content
Start triage

Start triage first, then route to emergency care.

Start symptom intake Emergency vets near you

Need urgent help? Start triage first, then route to emergency care.

Start symptom intake Emergency vets near you

Roxee Medication Guide

Pyriproxyfen

Medication reference facts with explicit FDA-approval, off-label, source-limited, and safety context. Roxee does not sell, prescribe, or dispense medications.

Both Source review pending No FDA approval linked Owner quick guide first
Start Symptom Intake Talk to a Vet / Find a Vet Near You

Veterinary professional?

Showing simplified owner view. Switch to Vet View for full technical detail.

Data freshness

Reference facts
Source review pending
No refresh timestamp yet

Roxee is still reviewing source support for this medication profile.

FDA applications
No FDA application data linked
No refresh timestamp yet

Sponsor, product, and application records imported from Animal Drugs @ FDA.

Safety reports
No safety reports linked
No refresh timestamp yet

openFDA reaction terms and case summaries are supporting evidence, not proof of causality.

Source timing details
Source timing details
  • Reference facts: Source Roxee | Refreshed May 2, 2026, 10:05 AM UTC
    The reference fact projection used for browse cards and quick facts.
Image coming soon
Pyriproxyfen

Pyriproxyfen

Drug type: Generic ingredient • Generic profile • No FDA approval linked

Both 56% reference complete

Species: Both

Approval status: No FDA animal-drug approval linked. Roxee has source-supported catalog facts for this medication, but no linked FDA animal-drug application or FDA animal-drug product record. The page should not be read as proof of FDA animal-drug approval; use only with veterinarian guidance.

Medication Snapshot

Merged from the current Roxee medication system with field-level provenance, freshness, and completeness tracking.

Pyriproxyfen

Generic name
Pyriproxyfen
Manufacturer
Manufacturer not confirmed in reference facts
Species
Both
Completeness
56%
Validation
Incomplete

Side Effects

Top reported reactions (openFDA): Lack of efficacy (ectoparasite) - flea, Pruritus, Vomiting, Lethargy (see also Central nervous system depression in 'Neurological'), Diarrhoea, Behavioural disorder NOS.

FAQ

Both

Source Transparency

Add to My Pet's Medications

Choose a pet, confirm current or past, and optionally add reminder notes.

Sign in to save this medication to your pet profile.

Sign in to continue

Pet Owner Quick Guide

Start here first for the safest next-step summary before the deeper medication detail.

Roxee still has limited plain-language guidance for this medication. Use the official documents and your veterinarian's instructions for product-specific details.

Used for:

Your vet decides this. Here's what owners typically ask/watch for.

Dosing note:

Exact dosing depends on your pet's species, weight, and health status. Use your veterinarian's instructions for the exact dose and schedule.

What to watch for:

  • Hives (1 reports)
  • Gut sounds increased (1 reports)
  • Generalised itching (1 reports)

When to call the vet:

  • Repeated vomiting or diarrhea.
  • Severe lethargy (hard to wake, very low energy).
  • Collapse or fainting.
  • Trouble breathing.
  • Facial swelling or hives.
  • Blood in vomit or stool.

What to tell or ask your vet today:

  • Is this medicine the right fit for my pet’s current symptoms?
  • Which warning signs mean I should call back right away?
  • How should I handle missed doses or refusal to take the medicine?

Next actions

Talk to a Vet / Find a Vet Near You Save to pet meds Share page Review report evidence
Research brief

Medication Research Insights

A source-aware map of what to know, what is uncertain, and what to verify with your veterinarian.

Source Backed Signals

What to know

Evidence-backed context Limited

Roxee has limited cited overview evidence for Pyriproxyfen; use the official documents and your veterinarian's instructions for product-specific decisions.

Source: openFDA case USA-USFDACVM-2025-US-072705
Safety signal coverage Reported signals

32 tracked reaction signals; 32 reported cases; 12 serious reports; 2 species groups. These are reporting and label-derived signals for interpretation with a veterinarian.

Source: openFDA case USA-USFDACVM-2025-US-072705
Interpretation guardrail Not causation

Adverse-event reports help form a watch list, but they do not prove the medication caused the reaction and they are not a risk ranking between medications.

Evidence tension

Stronger signal Label / review

Official labels, package inserts, and reviewed summaries carry more weight than isolated reports.

Source: openFDA case USA-USFDACVM-2025-US-072705
Weaker signal Reported data

Case reports and openFDA terms are useful for pattern awareness, but they are incomplete, can include multiple exposures, and do not estimate an individual pet's probability of harm.

Reaction signal map

Most reported reactions Top terms

Hives (1 reports), Gut sounds increased (1 reports), Generalised itching (1 reports), Gastroenteritis (1 reports), Gastritis (1 reports)

Body systems represented Signal grouping

Digestive (4), Skin & allergy (6), Neurologic (1), Behavior (1)

Species and breed lens

Species represented in reports Species lens

Dog (19 reports), Cat (13 reports)

What your vet may verify

Fit for this patient Vet check

Verify whether Pyriproxyfen fits the pet's species, current diagnosis, age, weight, organ status, pregnancy/lactation status, and concurrent medications.

Evidence limitations Evidence review

Separate label-backed warnings from adverse-event reports and owner observations before changing the plan.

What to watch next

Watch list Owner-safe

Hives, Gut sounds increased, Generalised itching

Call sooner if Escalation

Repeated vomiting or diarrhea. Severe lethargy (hard to wake, very low energy). Collapse or fainting.

Bottom line: Use this Pyriproxyfen brief as a structured watch list and source map, not as a reason to start, stop, or change treatment without your veterinarian.
Vet source depth
  1. openFDA case USA-USFDACVM-2025-US-072705 · adverse_reaction · adverse reactions

Evidence

Review status / Updated / Sources

Review status: Clinical reviewer not listed

Updated: May 2, 2026, 10:05 AM UTC

Sources:
Safety & side effects

Side effects to monitor:

  • Hives
  • Gut sounds increased
  • Generalised itching

Most reported reactions:

  • Hives (1 reports)
  • Gut sounds increased (1 reports)
  • Generalised itching (1 reports)

Emergency warning signs:

  • Repeated vomiting or diarrhea.
  • Severe lethargy (hard to wake, very low energy).
  • Collapse or fainting.
  • Trouble breathing.
Talk to a Vet / Find a Vet Near You Start Symptom Intake

Vet Fast Scan

Source-backed clinical checkpoints for quick review.

FDA-labeled species
Not linked yet
Indication / use
Your vet decides this. Here's what owners typically ask/watch for.
Form / route / dose
Confirm product label and patient-specific plan.
Warnings
No structured warnings linked yet.
Adverse-event caveat
No stored openFDA case explorer rows are linked yet.
Source docs
No source documents linked yet.

Quick Facts

Official label facts first, then secondary summaries. Marketing content is separated below.

Species: Both
Manufacturer: Manufacturer not confirmed

Adverse Reactions

Snapshot first, detailed rows second. This section summarizes signal data and is not a diagnosis.

Tap or hover a reaction to see what it means in plain language.

Tracked signals
32
Reported cases
32
Serious reports
12
Species represented
2
Grouped by Body System
Digestive (4) · Drooling, Diarrhea, Bloody diarrhoea Skin & allergy (6) · Hives, Generalised itching, Chewing - pruritus Neurologic (1) · Unsteady walking (ataxia) Behavior (1) · Behavioral disorder (unspecified) Other (20) · Hiding, Gut sounds increased, Gingivitis
Most Reported Reactions
Reaction Body system Cases Species Serious cases
Skin & allergy 1 Dog 1
Other 1 Dog 1
Skin & allergy 1 Dog 1
Other 1 Dog 1
Other 1 Dog 1
Other 1 Dog 1
Other 1 Dog 1
Other 1 Cat 1

Species coverage: Dog (19) Cat (13)

View detailed reaction table
Reaction Body system Species Seriousness Frequency Reports
Neurologic Dog Non-serious - 1
Skin & allergy Dog Serious - 1
Other Cat Non-serious - 1
Other Dog Serious - 1
Other Cat Non-serious - 1
Skin & allergy Dog Serious - 1
Other Dog Serious - 1
Other Dog Serious - 1
Other Cat Non-serious - 1
Digestive Cat Non-serious - 1
Other Dog Serious - 1
Digestive Dog Non-serious - 1
Other Dog Serious - 1
Other Cat Non-serious - 1
Other Cat Non-serious - 1
Other Cat Serious - 1
Other Cat Non-serious - 1
Other Cat Non-serious - 1
Skin & allergy Dog Non-serious - 1
Other Cat Serious - 1
Digestive Dog Serious - 1
Digestive Dog Serious - 1
Skin & allergy Dog Non-serious - 1
Behavior Cat Serious - 1
Other Dog Non-serious - 1
Other Dog Non-serious - 1
Other Dog Non-serious - 1
Skin & allergy Dog Non-serious - 1
Other Dog Non-serious - 1
Skin & allergy Dog Non-serious - 1
Other Cat Non-serious - 1
Other Cat Non-serious - 1
Source metadata:
Veterinary reference (advanced)

Canonical medication sections are above. This legacy block remains available for deeper cross-reference without cluttering the primary workflow.

At a Glance

Quick facts and links to official labeling and safety signals.

Data freshness
  • Reference facts: Source Roxee | Refreshed May 2, 2026, 10:05 AM UTC
    The reference fact projection used for browse cards and quick facts.
Official (FDA)
Identity: Generic ingredient • No FDA branded products linked
No official FDA brand rows linked yet for this ingredient.
Catalog species: Both
Safety (openFDA)
Top reactions: Dog 0 • Cat 0 • View
Case summaries: 0
openFDA reports are unverified and do not prove causation.
Diagnosis Codes

Diagnosis-code mappings are not available for this medication yet.

Counseling and Monitoring Highlights

Global Pet owner/Vet mode is controlled in the header. This section avoids duplicate in-page persona tabs.

Top reaction signals
Hives (1) Gut sounds increased (1) Generalised itching (1) Gastroenteritis (1) Gastritis (1) Digestive tract hypomotility (1) Dental calculus (1) Death (1)

Data Sources & Change Log

Every non-trivial field is expected to include provenance and update timestamps.

Official 2 Clinical 3 Manufacturer 0 Marketing 0
Current Field Facts
  • side_effects: Top reported reactions (openFDA): Lack of efficacy (ectoparasite) - flea, Pruritus, Vomiting, Lethargy (see also Central nervous system depression in 'Neurolog… (Clinical, 2026-05-02)
  • side_effects: Top reported reactions (openFDA): Lack of efficacy (ectoparasite) - flea, Pruritus, Vomiting, Lethargy (see also Central nervous system depression in 'Neurolog… (Clinical, 2026-04-15)
  • side_effects: Top reported reactions (openFDA): Lack of efficacy (ectoparasite) - flea, Pruritus, Vomiting, Lethargy (see also Central nervous system depression in 'Neurolog… (Clinical, 2026-04-11)
  • side_effects: Top reported reactions (openFDA): Lack of efficacy (ectoparasite) - flea, Pruritus, Vomiting, Lethargy (see also Central nervous system depression in 'Neurolog… (Official, 2026-04-30)
  • side_effects: Top reported reactions (openFDA): Lack of efficacy (ectoparasite) - flea, Pruritus, Vomiting, Lethargy (see also Central nervous system depression in 'Neurolog… (Official, 2026-02-12)
Recent Revisions
  • side_effects updated 2026-05-02 10:05 by etl_backfill • Backfilled from existing medication fields
  • side_effects updated 2026-04-30 10:09 by etl_backfill • Backfilled from existing medication fields
  • side_effects updated 2026-04-15 10:04 by etl_backfill • Backfilled from existing medication fields
  • side_effects updated 2026-04-11 10:05 by etl_backfill • Backfilled from existing medication fields
  • side_effects updated 2026-02-12 22:44 by etl_backfill • Backfilled from existing medication fields

Top Reported Reactions (openFDA)

De-duplicated reaction terms grouped by body system from FDA openFDA reports (not verified; does not prove causation).

Digestive
Drooling (1) • Cat Diarrhea (1) • Dog Bloody diarrhoea (1) • Dog Blood in vomit (1) • Dog

Showing top 5 for Digestive.

Skin & allergy
Hives (1) • Dog Generalised itching (1) • Dog Chewing - pruritus (1) • Dog Biting - pruritus (1) • Dog Application site hair loss (1) • Dog
Show more (1)
Alopecia local (1) • Dog

Showing top 5 for Skin & allergy.

Neurologic
Unsteady walking (1) • Dog

Showing top 5 for Neurologic.

Behavior
Behavioral disorder (1) • Cat

Showing top 5 for Behavior.

Other
Hiding (1) • Cat Gut sounds increased (1) • Dog Gingivitis (1) • Cat Gastroenteritis (1) • Dog Gastritis (1) • Dog
Show more (15)
Elevated alanine aminotransferase (1) • Cat Digestive tract hypomotility (1) • Dog Dental calculus (1) • Dog Dehydration (1) • Cat Decreased haematocrit (1) • Cat Death (1) • Cat Cough, hacking (1) • Cat Constipation (1) • Cat Chattering of teeth (1) • Cat Application site reddening (1) • Dog Application site reaction NOS (1) • Dog Application site irritation (1) • Dog Application site hair change (1) • Dog Administration error NOS (1) • Cat Abdominal pain (1) • Cat

Showing top 5 for Other.

Data source: FDA openFDA Animal & Veterinary adverse event reports.

Adverse Event Case Summaries (openFDA)

These are individual FDA adverse event reports. They are unverified and do not prove the medication caused the reaction.

No case-level openFDA reports are linked for this medication yet.

Data source: FDA openFDA Animal & Veterinary adverse event reports.

Overdose Information

No approved overdose-management text is linked yet. If overdose is suspected, contact a veterinarian or emergency clinic immediately.

Storage & Handling

No approved storage guidance is linked yet for this ingredient. Use manufacturer packaging and veterinary guidance for handling/storage.

Share Your Thoughts

Let others know your experience or advice regarding this medication.

This medication has not been reviewed by a veterinarian yet.