Roxee Medication Guide

Selamectin

Medication reference facts with explicit FDA-approval, off-label, source-limited, and safety context. Roxee does not sell, prescribe, or dispense medications.

Both Reference complete FDA data linked Rx required Liquid Multiple FDA labelers Official label facts Owner quick guide first

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Reference facts

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These are the reference facts Roxee uses on browse cards and quick facts.

FDA applications

FDA application data refreshed

Jun 22, 2026, 10:41 a.m.

Sponsor, product, and application records imported from Animal Drugs @ FDA.

Safety reports

Safety data refreshed

Jun 20, 2026, 8:54 p.m.

openFDA reaction terms and case summaries are supporting evidence, not proof of causality.

Source timing details

Reference facts: Source Roxee | Refreshed Jun 22, 2026, 10:41 AM UTC
The reference fact projection used for browse cards and quick facts.
Animal Drugs @ FDA: Source FDA | Refreshed Jun 22, 2026, 10:40 AM UTC
Applications/products are imported from FDA export data.
Animal Drugs @ FDA previews: Source FDA | Refreshed Feb 9, 2026, 3:05 AM UTC
Label highlights/doc links are fetched from FDA preview endpoints.
Animal Drug Product Listing Directory (NDC): Source FDA | Refreshed Jun 22, 2026, 10:41 AM UTC
Package/product NDCs from FDA’s electronic listing directory (XLS).
openFDA reaction terms: Source FDA openFDA | Refreshed Jun 22, 2026, 10:45 AM UTC
openFDA case summaries: Source FDA openFDA | Refreshed Jun 22, 2026, 10:45 AM UTC

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Selamectin

Drug type: Generic ingredient • Branded profile • FDA branded products available

Both Liquid Rx required 100% reference complete

Species: Both

Manufacturer: Multiple FDA labelers

Medication Snapshot

Merged from the current Roxee medication system with field-level provenance, freshness, and completeness tracking.

Selamectin

Revolution kills adult fleas and prevents flea eggs from hatching for one month and is indicated for the preventionand control of flea infestations ( Ctenocephalides felis ), prevention of heartworm disease caused by Dirofilariaimmitis, and the treatment and control of ear mite ( Otodectes cynotis ) infestations. Revolution is also indicatedfor the treatment and control of roundworm ( Toxocara cati ) and intestinal hookworm ( Ancylostoma tubaeforme )infections in cats. Revolution kills adult fleas and prevents flea eggs from hatching for one month andis indicated for the prevention and control of flea infestations ( Ctenocephalidesfelis ), prevention of heartworm disease caused by Dirofilaria immitis, and the treatment andcontrol of ear mite ( Otodectes cynotis ) infestations. Revolution also is indicated forthe treatment and control of sarcoptic mange ( Sarcoptes scabiei ) and for the controlof tick infestations due to Dermacentor variabilis. revolution® PLUS is indicated for the prevention of heartworm disease caused by Dirofilaria immitis, the treatment and control of roundworm ( Toxocara cati ) and intestinal hookworm ( Ancylostoma tubaeforme ) infections, and the treatment and control of ear mite ( Otodectes cynotis ) infestations. revolution® PLUS kills adult fleas ( Ctenocephalides felis ) and is indicated for the treatment and prevention of flea infestations, the prevention of Dipylidium caninum (tapeworm) infections as a direct result of killing Ctenocephalides felis vector fleas on the treated cat, and the treatment and control of tick infestations with Amblyomma americanum (lone star tick), Amblyomma maculatum (Gulf Coast tick), Dermacentor variabilis (American dog tick), and Ixodes scapularis (black-legged tick) for one month in cats and kittens 8 weeks and older, and weighing 2.8 pounds or greater. Species commonly shown: Both, Dog, Cat.

Generic name

Selamectin

Brand names

Revolution®, Selarid®, SENERGY™, Revolt®

Manufacturer

Multiple FDA labelers

Species

Both, Dog, Cat, 6 weeks of age and older

Dosage forms

Liquid, Topical Solution

Prescription

Prescription required

Completeness

100%

Validation

Complete

Brand names

Revolution® Selarid® SENERGY™ Revolt® SelaSpot™ Selamectin Selarid REVOLUTION SelaSpot Revolt SENERGY

Dosage forms

Liquid Topical Solution

Indications / Uses

Revolution kills adult fleas and prevents flea eggs from hatching for one month and is indicated for the preventionand control of flea infestations ( Ctenocephalides felis ), prevention of heartworm disease caused by Dirofilariaimmitis, and the treatment and control of ear mite ( Otodectes cynotis ) infestations. Revolution is also indicatedfor the treatment and control of roundworm ( Toxocara cati ) and intestinal hookworm ( Ancylostoma tubaeforme )infections in cats. Revolution kills adult fleas and prevents flea eggs from hatching for one month andis indicated for the prevention and control of flea infestations ( Ctenocephalidesfelis ), prevention of heartworm disease caused by Dirofilaria immitis, and the treatment andcontrol of ear mite ( Otodectes cynotis ) infestations. Revolution also is indicated forthe treatment and control of sarcoptic mange ( Sarcoptes scabiei ) and for the controlof tick infestations due to Dermacentor variabilis. revolution® PLUS is indicated for the prevention of heartworm disease caused by Dirofilaria immitis , the treatment and control of roundworm ( Toxocara cati ) and intestinal hookworm ( Ancylostoma tubaeforme ) infections, and the treatment and control of ear mite ( Otodectes cynotis ) infestations. revolution® PLUS kills adult fleas ( Ctenocephalides felis ) and is indicated for the treatment and prevention of flea infestations, the prevention of Dipylidium caninum (tapeworm) infections as a direct result of killing Ctenocephalides felis vector fleas on the treated cat, and the treatment and control of tick infestations with Amblyomma americanum (lone star tick), Amblyomma maculatum (Gulf Coast tick), Dermacentor variabilis (American dog tick), and Ixodes scapularis (black-legged tick) for one month in cats and kittens 8 weeks and older, and weighing 2.8 pounds or greater.

Warnings / Contraindications

Federal law restricts this drug to use by or on the order of a licensed veterinarian. Do not use in sick, debilitated, or underweight animals.

Federal law restricts this drug to use by or on the order of a licensed veterinarian. Do not use in sick, debilitated, or underweight animals.

Side Effects

Top reported reactions (openFDA): Lack of efficacy (ectoparasite) - flea, Lack of efficacy (endoparasite) - heartworm, Vomiting, Lethargy (see also Central nervous system depression in 'Neurological'), INEFFECTIVE, HEARTWORM LARVAE, Diarrhoea.

FAQ

Both, Dog, Cat, 6 weeks of age and older, 8 weeks of age and older

Yes. Roxee shows this as prescription-only.

Liquid, Topical Solution

Related Medications

Related Conditions

Fleas (Flea Infestation) Heartworm Disease Mange (sarcoptic mange, demodicosis) Pica Sarcoptic Mange (Scabies) Tick infestation

Source Transparency

Verified source: https://www.roxee.ai/meds/
Verified source: https://animaldrugsatfda.fda.gov
Verified source: https://animaldrugsatfda.fda.gov/adafda/views/#/search
Verified source: https://api.fda.gov/animalandveterinary/event.json
Verified source: https://www.roxee.ai/conditions/
Verified source: https://www.accessdata.fda.gov/spl/data/336409e4-461b-45bb-a4de-2d68551277a7/336409e4-461b-45bb-a4de-2d68551277a7.xml
Last refreshed: Jun 22, 2026, 10:41 a.m.
Last verified: Feb 12, 2026, 10:44 p.m.
Validation status: Complete

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Pet Owner Quick Guide

Start here first for the safest next-step summary before the deeper medication detail.

Used for:

Kills adult fleas and prevents flea eggs from hatching for one month and is indicated for the prevention and control of flea infestations ( Ctenocephalides felis ), prevention of heartworm disease caused by Dirofilaria i...

Dosing note:

Exact dosing depends on your pet's species, weight, and health status. Use your veterinarian's instructions for the exact dose and schedule.

What to watch for:

Do not use in sick, debilitated, or underweight animals
wobbly/unsteady walking (1 reports)
Head shake - ear disorder (1 reports)
Head down (1 reports)

When to call the vet:

Repeated vomiting or diarrhea.
Severe lethargy (hard to wake, very low energy).
Collapse or fainting.
Trouble breathing.
Facial swelling or hives.
Blood in vomit or stool.

Regulatory restrictions are shown in Vet View.

What to tell or ask your vet today:

Is this medicine the right fit for my pet’s current symptoms?
Which warning signs mean I should call back right away?
How should I handle missed doses or refusal to take the medicine?

Next actions

Talk to a Vet / Find a Vet Near You Save to pet meds Share page Review report evidence

Research brief

Medication Research Insights

A source-aware map of what to know, what is uncertain, and what to verify with your veterinarian.

Source Backed Signals

What to know

Evidence-backed context Limited

Roxee has limited cited overview evidence for Selamectin; use the official documents and your veterinarian's instructions for product-specific decisions.

Source: openFDA case USA-USFDACVM-2025-US-055194

Safety signal coverage Reported signals

32 tracked reaction signals; 32 reported cases; 25 serious reports; 2 species groups. These are reporting and label-derived signals for interpretation with a veterinarian.

Source: openFDA case USA-USFDACVM-2025-US-055194

Interpretation guardrail Not causation

Adverse-event reports help form a watch list, but they do not prove the medication caused the reaction and they are not a risk ranking between medications.

Evidence tension

Stronger signal Label / review

Official labels, package inserts, and reviewed summaries carry more weight than isolated reports.

Source: openFDA case USA-USFDACVM-2025-US-055194

Weaker signal Reported data

Case reports and openFDA terms are useful for pattern awareness, but they are incomplete, can include multiple exposures, and do not estimate an individual pet's probability of harm.

Reaction signal map

Most reported reactions Top terms

Unsteady walking (ataxia) (1 reports), Head shake - ear disorder (1 reports), Head down (1 reports), Fever (1 reports), Eosinophilia (1 reports)

Body systems represented Signal grouping

Digestive (2), Skin & allergy (2), Neurologic (1), Behavior (3)

Explore supporting adverse reports

Species and breed lens

Species represented in reports Species lens

Cat (24 reports), Dog (8 reports)

Breed metadata in reports Metadata only

Terrier (unspecified) (1), Domestic Shorthair (1), Dachshund - Miniature (1), Retriever - Labrador (1). These are report metadata, not proof that a breed is at higher risk.

What your vet may verify

Fit for this patient Vet check

Verify whether Selamectin fits the pet's species, current diagnosis, age, weight, organ status, pregnancy/lactation status, and concurrent medications.

Evidence limitations Evidence review

Separate label-backed warnings from adverse-event reports and owner observations before changing the plan.

What to watch next

Watch list Owner-safe

Do not use in sick, debilitated, or underweight animals, wobbly/unsteady walking, Head shake - ear disorder, Head down

Call sooner if Escalation

Repeated vomiting or diarrhea. Severe lethargy (hard to wake, very low energy). Collapse or fainting.

Bottom line: Use this Selamectin brief as a structured watch list and source map, not as a reason to start, stop, or change treatment without your veterinarian.

Vet source depth

openFDA case USA-USFDACVM-2025-US-055194 · adverse_reaction · adverse reactions
Contraindication source · fda_animal_drugs · warnings contraindications
FDA application profile · official_label · quick facts
FDA application profile · official_label · quick facts
Medication usage source · fda_animal_drugs · quick facts
FOI · document · documents
SPL · document · documents
FOI · document · documents

Evidence

Review status / Updated / Sources

Review status: Clinical reviewer not listed

Updated: February 12, 2026, 10:44 PM UTC

Sources:

FDA application profile · official_label
FDA application profile · official_label
Medication usage source · fda_animal_drugs
Selarid® · official_label
openFDA case USA-USFDACVM-2025-US-055194 · adverse_reaction

Safety & side effects

Side effects to monitor:

Do not use in sick, debilitated, or underweight animals
wobbly/unsteady walking
Head shake - ear disorder
Head down

Most reported reactions:

Unsteady walking (ataxia) (1 reports)
Head shake - ear disorder (1 reports)
Head down (1 reports)

Explore reported case details

Emergency warning signs:

Repeated vomiting or diarrhea.
Severe lethargy (hard to wake, very low energy).
Collapse or fainting.
Trouble breathing.

Talk to a Vet / Find a Vet Near You Start Symptom Intake

Vet Fast Scan

Source-backed clinical checkpoints for quick review.

FDA-labeled species

6 weeks of age and older, 8 weeks of age and older, Cat, Dog

Indication / use

Kills adult fleas and prevents flea eggs from hatching for one month and is indicated for the prevention and control of flea infestations ( Ctenocephalides felis ), prevention of …

Form / route / dose

Form: Liquid, Topical Solution
Route: Topical
Confirm product label and patient-specific plan.

Warnings

High: Federal law restricts this drug to use by or on the order of a licensed veterinarian. Do not use in sick, debilitated, …

Adverse-event caveat

openFDA adverse-event cases are reported signals. They are not verified, do not prove causation, and do not estimate a pet's individual risk.

Source docs

CIS SENERGY A200670G0003.pdf Owner handouts
CIS SELARID A200663G0001.pdf Owner handouts
CIS SELASPOT A200696A0000-2.pdf Owner handouts

Quick Facts

Official label facts first, then secondary summaries. Marketing content is separated below.

Species: Both

Manufacturer: Multiple FDA labelers

Form: Liquid, Topical Solution

Identifiers:

ANADA: 200663 ANADA: 200670 ANADA: 200673 ANADA: 200696 ANADA: 200769 NADA: 141152 NADA: 141502 NDC Package: 13985-966-15 NDC Package: 13985-966-45 NDC Package: 13985-966-60 NDC Package: 13985-967-12 NDC Package: 13985-967-20 NDC Package: 13985-967-30 NDC Package: 13985-967-60 NDC Package: 20076-0000-3 NDC Package: 20076-0000-4 NDC Package: 50989-317-99 NDC Package: 50989-318-99 NDC Package: 50989-319-99 NDC Package: 50989-320-99

Source metadata:

https://animaldrugsatfda.fda.gov/adafda/views/#/home/previewsearch/200769 · official_label · FDA application profile
https://animaldrugsatfda.fda.gov/adafda/views/#/home/previewsearch/200670 · official_label · FDA application profile
https://animaldrugsatfda.fda.gov · fda_animal_drugs · Medication usage source

Warnings / Contraindications

Federal law restricts this drug to use by or on the order of a licensed veterinarian. Do not use in sick, debilitated, or underweight animals.

High: Federal law restricts this drug to use by or on the order of a licensed veterinarian. Do not use in sick, debilitated, or underweight animals.

Source metadata:

https://animaldrugsatfda.fda.gov · fda_animal_drugs · Contraindication source

Adverse Reactions

Snapshot first, detailed rows second. This section summarizes signal data and is not a diagnosis.

Reported case explorer

Filter stored openFDA reports by pet and report attributes. Counts describe reports in this data set, not risk.

Clear filters

openFDA adverse-event cases are reported signals. They are not verified, do not prove causation, and do not estimate a pet's individual risk.

Stored reports

Matching reports

Active filters

Selected filters

Reaction: Not eating Clear Body system: Other Clear

Species

Breed

Size / weight

Age

Sex

Seriousness

Outcome

Reaction

Body system

Region

Received after

Received before

Reset

Drill into common report signals

Lethargy (see also Central nervous system depression in Neurological) (6) Not eating (5) Death (4) Not drinking (4) Other (19) Neurologic (8) Effectiveness (7) Digestive (6)

Showing up to 50 matching reports.

USA-USFDACVM-2025-US-074692

Received 2025-12-18 · MSK · MSK

Non-serious

Species: Cat
Breed: American Shorthair
Size / weight: Under 10 lb (4.5 Kilogram)
Age: 4-7 years (4.83 Year)
Sex: Female Neutered
Region: USA
Reactions: Not eatingWalking difficultyFallingUnable to standAnisocoriaThird eyelid protrusion
Body systems: Other
Outcomes: Ongoing

USA-USFDACVM-2025-US-074155

Received 2025-12-16 · MSK · MSK

Serious

Species: Dog
Breed: Terrier - Yorkshire
Size / weight: Under 10 lb (0.395 Kilogram)
Age: Under 1 year (2 Month)
Sex: Female Intact
Region: USA
Reactions: ShakingHypersalivationLethargy (see also Central nervous system depression in Neurological)Head tremorAtaxiaNot eatingNot drinkingDry mucous membraneEosinophiliaThrombocytosisElevated gamma-glutamyl transferase (GGT)HypoglycaemiaHypokalaemiaSeizure NOS
Body systems: OtherDigestiveNeurologic
Outcomes: Ongoing

USA-USFDACVM-2025-US-071642

Received 2025-11-10 · MSK · MSK

Serious

Species: Cat
Breed: Domestic Shorthair
Size / weight: Under 10 lb (3.8 Kilogram)
Age: 4-7 years (7 Year)
Sex: Female Neutered
Region: USA
Reactions: Balance problemMuscle tremorDeafnessNot eatingNot drinkingIrritabilityVocalisationAnxietyHead shake - ear disorderScratchingEar dischargeNeurological disorder NOS
Body systems: OtherNeurologicBehavior
Outcomes: Recovered with Sequela

USA-USFDACVM-2025-US-064137

Received 2025-10-29 · MSK · MSK

Serious

Species: Cat
Breed: Domestic Longhair
Size / weight: Under 10 lb (1.098 Kilogram)
Age: Under 1 year (3 Month)
Sex: Female Unknown
Region: USA
Reactions: Not eatingNot drinkingRespiratory tract infection NOSDiarrhoeaVomitingWeight lossUnkempt hair coat
Body systems: OtherDigestive
Outcomes: Ongoing

USA-USFDACVM-2025-US-065693

Received 2025-10-28 · MSK · MSK

Serious

Species: Cat
Breed: Domestic Shorthair
Size / weight: Under 10 lb (3.8 Kilogram)
Age: 4-7 years (7 Year)
Sex: Female Neutered
Region: USA
Reactions: Balance problemMuscle tremorDeafnessNot eatingNot drinkingIrritabilityVocalisationAnxietyHead shake - ear disorderScratchingEar dischargeDistressAttention-seeking behaviour
Body systems: OtherNeurologicBehavior
Outcomes: Recovered with Sequela

Tap or hover a reaction to see what it means in plain language.

Tracked signals

Reported cases

Serious reports

Species represented

Grouped by Body System

Digestive (2) · Vomiting, Diarrhea Skin & allergy (2) · Hair loss at application site, Chewing - pruritus Neurologic (1) · Unsteady walking (ataxia) Behavior (3) · Behavioral disorder (unspecified), Attention-seeking behaviour, Anxiety Other (24) · Head shake - ear disorder, Head down, Fever

Most Reported Reactions

Body system	Cases	Species	Serious cases
Neurologic	1	Dog	1
Other	1	Cat	1
Other	1	Cat	1
Other	1	Cat	1
Other	1	Dog	1
Other	1	Dog	1
Other	1	Cat	1
Other	1	Dog	1

Species coverage: Cat (24) Dog (8)

View detailed reaction table

Body system	Species	Seriousness	Frequency	Reports
Digestive	Dog	Non-serious	-	1
Neurologic	Dog	Serious	-	1
Other	Cat	Serious	-	1
Other	Cat	Serious	-	1
Skin & allergy	Cat	Non-serious	-	1
Other	Cat	Serious	-	1
Other	Cat	Non-serious	-	1
Other	Dog	Serious	-	1
Other	Dog	Serious	-	1
Other	Cat	Non-serious	-	1
Other	Cat	Serious	-	1
Other	Dog	Serious	-	1
Other	Cat	Serious	-	1
Digestive	Cat	Serious	-	1
Other	Dog	Serious	-	1
Other	Cat	Serious	-	1
Other	Cat	Serious	-	1
Other	Cat	Serious	-	1
Other	Cat	Serious	-	1
Other	Cat	Serious	-	1
Skin & allergy	Cat	Serious	-	1
Other	Cat	Serious	-	1
Behavior	Dog	Non-serious	-	1
Other	Cat	Serious	-	1
Behavior	Cat	Serious	-	1
Other	Cat	Non-serious	-	1
Behavior	Cat	Serious	-	1
Other	Cat	Non-serious	-	1
Other	Cat	Serious	-	1
Other	Cat	Serious	-	1
Other	Dog	Serious	-	1
Other	Cat	Serious	-	1

Source metadata:

https://api.fda.gov/animalandveterinary/event.json · adverse_reaction · openFDA case USA-USFDACVM-2025-US-055194

Source Documents

The most useful source links appear first; full previews and metadata stay in the veterinary/professional layer.

Use original documents to confirm product-specific warnings, ingredients, and handling details with your veterinarian.

CIS SENERGY A200670G0003.pdf Owner handouts · Labeling CIS SELARID A200663G0001.pdf Owner handouts · Labeling CIS SELASPOT A200696A0000-2.pdf Owner handouts · Labeling

Full source previews and metadata remain in the veterinary/professional layer.

Owner handouts

Official label / PI

SPL

Open original

Selamectin

SPL · SPL

Open original

FDA Structured Product Label

Selamectin

Rendered from Roxee's cached FDA SPL package contents for on-page reading. Use Open original for the raw FDA ZIP/XML source.

Sponsor: ZYVET AH, Inc.
ANADA: 200-769
Status: RX
Form: Topical Solution
Route: Topical
Species: Dog • Cat

Composition / specifications

60 mg/mL and 120 mg/mL

Dogs (6 Weeks of Age or Older)

Indication

Indication

Indication

Revolution kills adult fleas and prevents flea eggs from hatching for one month and is indicated for the preventionand control of flea infestations (Ctenocephalides felis), prevention of heartworm disease caused by Dirofilariaimmitis, and the treatment and control of ear mite (Otodectes cynotis) infestations. Revolution is also indicatedfor the treatment and control of roundworm (Toxocara cati) and intestinal hookworm (Ancylostoma tubaeforme)infections in cats.

Dosage

The recommended minimum dose is 2.7 mg selamectin per pound (6 mg/kg) of body weight.

Limitations

Federal law restricts this drug to use by or on the order of a licensed veterinarian. Do not use in sick, debilitated, or underweight animals.

Dogs (6 Weeks of Age or Older)

Indication

Revolution kills adult fleas and prevents flea eggs from hatching for one month andis indicated for the prevention and control of flea infestations (Ctenocephalidesfelis), prevention of heartworm disease caused by Dirofilaria immitis, and the treatment andcontrol of ear mite (Otodectes cynotis) infestations. Revolution also is indicated forthe treatment and control of sarcoptic mange (Sarcoptes scabiei) and for the controlof tick infestations due to Dermacentor variabilis.

Dosage

The recommended minimum dose is 2.7 mg selamectin per pound (6 mg/kg) of body weight.

Limitations

Federal law restricts this drug to use by or on the order of a licensed veterinarian. Do not use in sick, debilitated, or underweight animals.

SelaSpot™

SPL · SPL

Open original

FDA Structured Product Label

SelaSpot™

Rendered from Roxee's cached FDA SPL package contents for on-page reading. Use Open original for the raw FDA ZIP/XML source.

Sponsor: Bimeda Animal Health Ltd.
ANADA: 200-696
Status: RX
Form: Topical Solution
Route: Topical
Species: Dog • Cat

Composition / specifications

60 mg/mL and 120 mg/mL

Dogs

Indication

In dogs six weeks of age or older, kills adult fleas and prevents flea eggs from hatching for one month and is indicated for the prevention and control of flea infestations (Ctenocephalides felis), prevention of heartworm disease caused by Dirofilaria immitis, and the treatment and control of ear mite (Otodectes cynotis) infestations. It is also indicated for the treatment and control of sarcoptic mange (Sarcoptes scabiei) and for the control of tick infestations due to Dermacentor variabilis.

Dosage

Administer topically 2.7 mg of selamectin per pound (6 mg per kilogram) of body weight.

Cats

Indication

SPL · Structured Product Label

https://animaldrugsatfda.fda.gov/adafda/app/search/public/document/downloadFoi/14985 · document · FOI
https://animaldrugsatfda.fda.gov/adafda/app/search/public/spl/file/15223/Selamectin · document · SPL
https://animaldrugsatfda.fda.gov/adafda/app/search/public/document/downloadFoi/8527 · document · FOI
https://animaldrugsatfda.fda.gov/adafda/app/search/public/document/downloadLabeling/907 · document · Labeling
https://animaldrugsatfda.fda.gov/adafda/app/search/public/document/downloadLabeling/908 · document · Labeling
https://animaldrugsatfda.fda.gov/adafda/app/search/public/spl/file/8609/SENERGY%E2%84%A2 · document · SPL
https://animaldrugsatfda.fda.gov/adafda/app/search/public/document/downloadFoi/7948 · document · FOI
https://animaldrugsatfda.fda.gov/adafda/app/search/public/document/downloadLabeling/901 · document · Labeling
https://animaldrugsatfda.fda.gov/adafda/app/search/public/document/downloadLabeling/902 · document · Labeling
https://animaldrugsatfda.fda.gov/adafda/app/search/public/spl/file/7990/Selarid%C2%AE · document · SPL

Veterinary reference (advanced)

Canonical medication sections are above. This legacy block remains available for deeper cross-reference without cluttering the primary workflow.

At a Glance

Quick facts and links to official labeling and safety signals.

Data freshness

Reference facts: Source Roxee | Refreshed Jun 22, 2026, 10:41 AM UTC
The reference fact projection used for browse cards and quick facts.
Animal Drugs @ FDA: Source FDA | Refreshed Jun 22, 2026, 10:40 AM UTC
Applications/products are imported from FDA export data.
Animal Drugs @ FDA previews: Source FDA | Refreshed Feb 9, 2026, 3:05 AM UTC
Label highlights/doc links are fetched from FDA preview endpoints.
Animal Drug Product Listing Directory (NDC): Source FDA | Refreshed Jun 22, 2026, 10:41 AM UTC
Package/product NDCs from FDA’s electronic listing directory (XLS).
openFDA reaction terms: Source FDA openFDA | Refreshed Jun 22, 2026, 10:45 AM UTC
openFDA case summaries: Source FDA openFDA | Refreshed Jun 22, 2026, 10:45 AM UTC

Official (FDA)

Identity: Generic ingredient • FDA branded products available

Official FDA brands: REVOLUTION Revolt SENERGY SelaSpot Selamectin Selarid

Manufacturer mapping: Multiple FDA labelers

Case-reported brands (openFDA): MSK

Catalog species: Both • FDA-labeled species: 6 weeks of age and older, 8 weeks of age and older, Cat, Dog

Rx/OTC: RX

Form/route: Liquid, Topical Solution • Topical

Applications: ANADA 200-769 • ANADA 200-670 • ANADA 200-663 • ANADA 200-673 • NADA 141-152 • ANADA 200-696

NDC: Packages 13985-966-15 13985-966-45 13985-966-60 13985-967-12 13985-967-20 13985-967-30 • Products 13985 20076 50989 51072 51311 54771

Documents: 18 (FOI: 8) • SPL: 6 • Label highlights • Official documents

Safety (openFDA)

Top reactions: Dog 30 • Cat 54 • View

Case summaries: 25 (showing 8) • View

openFDA reports are unverified and do not prove causation.

Explore

Related conditions: Fleas (Flea Infestation) Heartworm Disease Mange (sarcoptic mange, demodicosis) Pica Sarcoptic Mange (Scabies) Tick infestation

Linked using: Fda_Label (0.95), Fda_Label (0.95), Fda_Label (0.95)

Diagnosis Codes

ICD10_CM: B74.8 ICD10_CM: B86 ICD10_CM: B88.1

Other filariases

Counseling and Monitoring Highlights

Global Pet owner/Vet mode is controlled in the header. This section avoids duplicate in-page persona tabs.

Owner-facing counseling points

Federal law restricts this drug to use by or on the order of a licensed veterinarian. Do not use in sick, debilitated, or underweight animals. (Contraindication, High)

Top reaction signals

Unsteady walking (ataxia) (1) Head shake - ear disorder (1) Head down (1) Fever (1) Eosinophilia (1) Elevated gamma-glutamyl transferase (1) Ear discharge (1) Dry mucous membrane (1)

Identifiers & Packages

Normalized identifiers (NDC/NADA/ANADA) and package metadata from regulator listings.

Identifiers

Package NDC	Product NDC	Status
13985-966-15	13985	-
13985-966-45	13985	-
13985-966-60	13985	-
13985-967-12	13985	-
13985-967-20	13985	-
13985-967-30	13985	-
13985-967-60	13985	-
20076-0000-3	20076	-
20076-0000-4	20076	-
50989-317-99	50989	-
50989-318-99	50989	-
50989-319-99	50989	-
50989-320-99	50989	-
50989-321-99	50989	-
50989-322-99	50989	-
50989-323-99	50989	-
50989-324-99	50989	-
51072-097-01	51072	-
51072-097-02	51072	-
51072-097-03	51072	-

Enriched Documents

Documents are tiered by source trust: Official, Clinical, Manufacturer, Marketing.

Selamectin SPL • Structured Product Label • Official
FDA Structured Product Label from the electronic animal drug product listing directory.
REVOLUTION SPL • Structured Product Label • Official
FDA Structured Product Label from the electronic animal drug product listing directory.
Selamectin SPL • Structured Product Label • Official
FDA Structured Product Label from the electronic animal drug product listing directory.
Selarid SPL • Structured Product Label • Official
FDA Structured Product Label from the electronic animal drug product listing directory.
SENERGY SPL • Structured Product Label • Official
FDA Structured Product Label from the electronic animal drug product listing directory.
Revolt SPL • Structured Product Label • Official
FDA Structured Product Label from the electronic animal drug product listing directory.
Selarid SPL • Structured Product Label • Official
FDA Structured Product Label from the electronic animal drug product listing directory.
SelaSpot SPL • Structured Product Label • Official
FDA Structured Product Label from the electronic animal drug product listing directory.
FOI Summary oN 141-502 Approved November 9, 2018.pdf • FOI summary • Official • Dec. 2, 2024
FDA FOI summary for application 141502
FOI Summary sN 141-502 Approved December 14, 2023.pdf • FOI summary • Official • Dec. 2, 2024
FDA FOI summary for application 141502
FOI Summary sN 141-502 Approved November 13, 2024.pdf • FOI summary • Official • Dec. 2, 2024
FDA FOI summary for application 141502
FOI Summary oA 200-769 Approved January 30, 2024.pdf • FOI summary • Official • Feb. 1, 2024
FDA FOI summary for application 200769
PI SENERGY A200670G0003.pdf • Official label • Official • Oct. 24, 2023
FDA official labeling for application 200670
CIS SENERGY A200670G0003.pdf • Official label • Official • Oct. 24, 2023
FDA official labeling for application 200670
FOI Summary oA 200-670 Approved March 10, 2020.pdf • FOI summary • Official • Oct. 24, 2023
FDA FOI summary for application 200670
Package Insert SELARID A200663G0001.pdf • Official label • Official • Sept. 7, 2023
FDA official labeling for application 200663
CIS SELARID A200663G0001.pdf • Official label • Official • Sept. 7, 2023
FDA official labeling for application 200663
FOI Summary oA 200-663 Approved November 20, 2019.pdf • FOI summary • Official • Sept. 7, 2023
FDA FOI summary for application 200663
REVOLT A200673G0003.pdf • Official label • Official • June 7, 2021
FDA official labeling for application 200673
REVOLT A200673G0003.pdf • Official label • Official • June 7, 2021
FDA official labeling for application 200673
FOI Summary oA 200-673 Approved April 22, 2020.pdf • FOI summary • Official • June 7, 2021
FDA FOI summary for application 200673
PI SELASPOT A200696A0000.pdf • Official label • Official • May 17, 2021
FDA official labeling for application 200696
CIS SELASPOT A200696A0000-2.pdf • Official label • Official • May 17, 2021
FDA official labeling for application 200696
FOI Summary oA 200-696 Approved December 16, 2020.pdf • FOI summary • Official • May 17, 2021
FDA FOI summary for application 200696
Final Version REVOLUTION N141152C0093.pdf • Official label • Official • May 17, 2021
FDA official labeling for application 141152
Final Version REVOLUTION N141152C0093.pdf • Official label • Official • May 17, 2021
FDA official labeling for application 141152
ucm117201.pdf • FOI summary • Official • May 17, 2021
FDA FOI summary for application 141152
ucm117203.pdf • FOI summary • Official • May 17, 2021
FDA FOI summary for application 141152
ucm117204.pdf • FOI summary • Official • May 17, 2021
FDA FOI summary for application 141152

Data Sources & Change Log

Every non-trivial field is expected to include provenance and update timestamps.

Official 148 Clinical 1 Manufacturer 0 Marketing 0

Current Field Facts

side_effects: Top reported reactions (openFDA): Lack of efficacy (ectoparasite) - flea, Lack of efficacy (endoparasite) - heartworm, Vomiting, Lethargy (see also Central ner… (Clinical, 2026-04-11)
contraindications: Federal law restricts this drug to use by or on the order of a licensed veterinarian. Do not use in sick, debilitated, or underweight animals. (Official, 2026-04-12)
contraindications: Federal law restricts this drug to use by or on the order of a licensed veterinarian. Do not use in sick, debilitated, or underweight animals. (Official, 2026-04-11)
contraindications: Federal law restricts this drug to use by or on the order of a licensed veterinarian. Do not use in sick, debilitated, or underweight animals. (Official, 2026-02-12)
indications: For dogs 6 weeks of age and older: Kills adult fleas and prevents flea eggs from hatching for 1 month, and it is indicated for the prevention and control of fl… (Official, 2026-06-22)
indications: For dogs 6 weeks of age and older: Kills adult fleas and prevents flea eggs from hatching for 1 month, and it is indicated for the prevention and control of fl… (Official, 2026-06-22)
indications: For dogs 6 weeks of age and older: Kills adult fleas and prevents flea eggs from hatching for 1 month, and it is indicated for the prevention and control of fl… (Official, 2026-06-21)
indications: For dogs 6 weeks of age and older: Kills adult fleas and prevents flea eggs from hatching for 1 month, and it is indicated for the prevention and control of fl… (Official, 2026-06-20)
indications: For dogs 6 weeks of age and older: Kills adult fleas and prevents flea eggs from hatching for 1 month, and it is indicated for the prevention and control of fl… (Official, 2026-06-13)
indications: For dogs 6 weeks of age and older: Kills adult fleas and prevents flea eggs from hatching for 1 month, and it is indicated for the prevention and control of fl… (Official, 2026-06-12)
indications: For dogs 6 weeks of age and older: Kills adult fleas and prevents flea eggs from hatching for 1 month, and it is indicated for the prevention and control of fl… (Official, 2026-06-12)
indications: For dogs 6 weeks of age and older: Kills adult fleas and prevents flea eggs from hatching for 1 month, and it is indicated for the prevention and control of fl… (Official, 2026-06-11)
indications: For dogs 6 weeks of age and older: Kills adult fleas and prevents flea eggs from hatching for 1 month, and it is indicated for the prevention and control of fl… (Official, 2026-06-11)
indications: For dogs 6 weeks of age and older: Kills adult fleas and prevents flea eggs from hatching for 1 month, and it is indicated for the prevention and control of fl… (Official, 2026-06-10)
indications: For dogs 6 weeks of age and older: Kills adult fleas and prevents flea eggs from hatching for 1 month, and it is indicated for the prevention and control of fl… (Official, 2026-06-09)
indications: For dogs 6 weeks of age and older: Kills adult fleas and prevents flea eggs from hatching for 1 month, and it is indicated for the prevention and control of fl… (Official, 2026-06-08)
indications: For dogs 6 weeks of age and older: Kills adult fleas and prevents flea eggs from hatching for 1 month, and it is indicated for the prevention and control of fl… (Official, 2026-06-07)
indications: For dogs 6 weeks of age and older: Kills adult fleas and prevents flea eggs from hatching for 1 month, and it is indicated for the prevention and control of fl… (Official, 2026-06-06)
indications: For dogs 6 weeks of age and older: Kills adult fleas and prevents flea eggs from hatching for 1 month, and it is indicated for the prevention and control of fl… (Official, 2026-06-05)
indications: For dogs 6 weeks of age and older: Kills adult fleas and prevents flea eggs from hatching for 1 month, and it is indicated for the prevention and control of fl… (Official, 2026-06-04)

Recent Revisions

side_effects updated 2026-04-12 10:05 by etl_backfill • Backfilled from existing medication fields
contraindications updated 2026-04-12 10:05 by etl_backfill • Backfilled from existing medication fields
usage updated 2026-04-12 10:05 by etl_backfill • Backfilled from existing medication fields
side_effects updated 2026-04-11 10:05 by etl_backfill • Backfilled from existing medication fields
contraindications updated 2026-04-11 10:05 by etl_backfill • Backfilled from existing medication fields
usage updated 2026-04-11 10:05 by etl_backfill • Backfilled from existing medication fields
side_effects updated 2026-02-12 22:44 by etl_backfill • Backfilled from existing medication fields
contraindications updated 2026-02-12 22:44 by etl_backfill • Backfilled from existing medication fields
usage updated 2026-02-12 22:44 by etl_backfill • Backfilled from existing medication fields

FDA Products & Applications (Animal Drugs @ FDA)

Official sponsor/proprietary-name/application-status records linked by active ingredient.

Product	Sponsor	Application	Status	Published
Selamectin RX Selamectin Topical Solution • Topical Label highlights Official documents	ZYVET AH, Inc.	ANADA 200-769	Approved	Feb 1, 2024
SENERGY™ RX Selamectin Topical Solution • Topical Label highlights Official documents	Virbac AH, Inc.	ANADA 200-670	Approved	Oct 24, 2023
Selarid® RX Selamectin Topical Solution • Topical Label highlights Official documents	Norbrook Laboratories, Ltd.	ANADA 200-663	Approved	Sep 7, 2023
Revolt® RX Selamectin Topical Solution • Topical Label highlights Official documents	Aurora Pharmaceutical, Inc.	ANADA 200-673	Approved	Jun 7, 2021
Revolution® RX Selamectin Liquid • Topical Label highlights Official documents	Zoetis Inc.	NADA 141-152	Approved	May 17, 2021
SelaSpot™ RX Selamectin Topical Solution • Topical Label highlights Official documents	Bimeda Animal Health Ltd.	ANADA 200-696	Approved	May 17, 2021

Data source: FDA Animal Drugs @ FDA (public search export).

What It's For (FDA Label Highlights)

Extracted from FDA Animal Drugs @ FDA product labeling. Always confirm details with your veterinarian.

Species: Dog • Cat

Composition / specifications

60 mg/mL and 120 mg/mL

Dogs (6 Weeks of Age or Older)

Indication

Dosage

The recommended minimum dose is 2.7 mg selamectin per pound (6 mg/kg) of body weight.

Limitations

Cats (8 Weeks of Age and Older)

Indication

Kills adult fleas and prevents flea eggs from hatching for one month and is indicated for the prevention and control of flea infestations (Ctenocephalides felis), prevention of heartworm disease caused by Dirofilaria immitis, and the treatment and control of ear mite (Otodectes cynotis) infestations. It is also indicated for the treatment and control of roundworm (Toxocara cati) and intestinal hookworm (Ancylostoma tubaeforme) infections in cats.

Dosage

The recommended minimum dose is 2.7 mg selamectin per pound (6 mg/kg) of body weight.

Limitations

FDA page: Open in Animal Drugs @ FDA

Species: 6 weeks of age and older • 8 weeks of age and older

Composition / specifications

60 mg/mL and 120 mg/mL

Dogs

Indication

Dosage

The recommended minimum dose is 2.7 mg selamectin per pound (6 mg/kg) of body weight.

Limitations

Cats

Indication

Kills adult fleas and prevents flea eggs from hatching for one month and is indicated for the prevention and control of flea infestations (Ctenocephalides felis), prevention of heartworm disease caused by Dirofilaria immitis, and the treatment and control of ear mite (Otodectes cynotis) infestations. It is also indicated for the treatment and control of roundworm (Toxocara cati) and intestinal hookworm (Ancylostoma tubaeforme) infections in cats.

Dosage

The recommended minimum dose is 2.7 mg selamectin per pound (6 mg/kg) of body weight.

Limitations

FDA page: Open in Animal Drugs @ FDA

Species: 6 weeks of age and older • 8 weeks of age and older

Composition / specifications

60 mg/mL and 120 mg/mL

Dogs 6 weeks of age and older

Indication

Dosage

2.7 milligrams of selamectin, topically, per pound (6 milligrams per kilogram) of body weight.

Limitations

Cats 8 weeks of age and older

Indication

Kills adult fleas and prevents flea eggs from hatching for 1 month, and it is indicated for the prevention and control of flea infestations (Ctenocephalides felis), prevention of heartworm disease caused by Dirofilaria immitis, and treatment and control of ear mite (Otodectes cynotis) infestations. Treatment and control of intestinal hookworm (Ancylostoma tubaeforme) and roundworm (Toxocara cati) infections.

Dosage

2.7 milligrams of selamectin, topically, per pound (6 milligrams per kilogram) of body weight.

Limitations

FDA page: Open in Animal Drugs @ FDA

Species: 6 weeks of age and older • 8 weeks of age and older

Composition / specifications

60 mg/mL or 120 mg/mL

Dogs

Indication

Dosage

The recommended minimum dose is 2.7 mg selamectin per pound (6 mg/kg) of body weight.

Limitations

Cats

Indication

Kills adult fleas and prevents flea eggs from hatching for one month and is indicated for the prevention and control of flea infestations (Ctenocephalides felis), prevention of heartworm disease caused by Dirofilaria immitis, and the treatment and control of ear mite (Otodectes cynotis) infestations. It is also indicated for the treatment and control of roundworm (Toxocara cati) and intestinal hookworm (Ancylostoma tubaeforme) infections in cats.

Dosage

The recommended minimum dose is 2.7 mg selamectin per pound (6 mg/kg) of body weight.

Limitations

FDA page: Open in Animal Drugs @ FDA

Species: Dog • Cat

Composition / specifications

60 or 120 mg/mL selamectin.

Cats (8 Weeks of Age and Older)

Indication

Dosage

The recommended minimum dose is 2.7 mg selamectin per pound (6 mg/kg) of body weight.

Limitations

Federal law restricts this drug to use by or on the order of a licensed veterinarian. Do not use in sick, debilitated, or underweight animals.

Dogs (6 Weeks of Age or Older)

Indication

Revolution kills adult fleas and prevents flea eggs from hatching for one month andis indicated for the prevention and control of flea infestations (Ctenocephalidesfelis), prevention of heartworm disease caused by Dirofilaria immitis, and the treatment andcontrol of ear mite (Otodectes cynotis) infestations. Revolution also is indicated forthe treatment and control of sarcoptic mange (Sarcoptes scabiei) and for the controlof tick infestations due to Dermacentor variabilis.

Dosage

The recommended minimum dose is 2.7 mg selamectin per pound (6 mg/kg) of body weight.

Limitations

Federal law restricts this drug to use by or on the order of a licensed veterinarian. Do not use in sick, debilitated, or underweight animals.

FDA page: Open in Animal Drugs @ FDA

Species: Dog • Cat

Composition / specifications

60 mg/mL and 120 mg/mL

Dogs

Indication

Dosage

Administer topically 2.7 mg of selamectin per pound (6 mg per kilogram) of body weight.

Limitations

Cats

Indication

Dosage

Administer topically 2.7 mg of selamectin per pound (6 mg per kilogram) of body weight.

Limitations

FDA page: Open in Animal Drugs @ FDA

Usage

Revolution kills adult fleas and prevents flea eggs from hatching for one month and is indicated for the preventionand control of flea infestations ( Ctenocephalides felis ), prevention of heartworm disease caused by Dirofilariaimmitis, and the treatment and control of ear mite ( Otodectes cynotis ) infestations. Revolution is also indicatedfor the treatment and control of roundworm ( Toxocara cati ) and intestinal hookworm ( Ancylostoma tubaeforme )infections in cats. Revolution kills adult fleas and prevents flea eggs from hatching for one month andis indicated for the prevention and control of flea infestations ( Ctenocephalidesfelis ), prevention of heartworm disease caused by Dirofilaria immitis, and the treatment andcontrol of ear mite ( Otodectes cynotis ) infestations. Revolution also is indicated forthe treatment and control of sarcoptic mange ( Sarcoptes scabiei ) and for the controlof tick infestations due to Dermacentor variabilis. revolution® PLUS is indicated for the prevention of heartworm disease caused by Dirofilaria immitis , the treatment and control of roundworm ( Toxocara cati ) and intestinal hookworm ( Ancylostoma tubaeforme ) infections, and the treatment and control of ear mite ( Otodectes cynotis ) infestations. revolution® PLUS kills adult fleas ( Ctenocephalides felis ) and is indicated for the treatment and prevention of flea infestations, the prevention of Dipylidium caninum (tapeworm) infections as a direct result of killing Ctenocephalides felis vector fleas on the treated cat, and the treatment and control of tick infestations with Amblyomma americanum (lone star tick), Amblyomma maculatum (Gulf Coast tick), Dermacentor variabilis (American dog tick), and Ixodes scapularis (black-legged tick) for one month in cats and kittens 8 weeks and older, and weighing 2.8 pounds or greater.

Source: FDA Animal Drugs @ FDA • Reference

Contraindications

Federal law restricts this drug to use by or on the order of a licensed veterinarian. Do not use in sick, debilitated, or underweight animals.

Top Reported Reactions (openFDA)

De-duplicated reaction terms grouped by body system from FDA openFDA reports (not verified; does not prove causation).

Digestive

Vomiting (1) • Dog Diarrhea (1) • Cat

Showing top 5 for Digestive.

Skin & allergy

Hair loss at application site (1) • Cat Chewing - pruritus (1) • Cat

Showing top 5 for Skin & allergy.

Neurologic

Unsteady walking (1) • Dog

Showing top 5 for Neurologic.

Behavior

Behavioral disorder (1) • Dog Attention-seeking behaviour (1) • Cat Anxiety (1) • Cat

Showing top 5 for Behavior.

Other

Head shake - ear disorder (1) • Cat Head down (1) • Cat Fever (1) • Cat Falling (1) • Cat Eosinophilia (1) • Dog

Show more (19)

Elevated gamma-glutamyl transferase (1) • Dog Elevated betahydroxybutyrate (1) • Cat Ear discharge (1) • Cat Dry mucous membrane (1) • Dog Distress (1) • Cat Dermatitis (1) • Dog Decreased packed cell volume (1) • Cat Decreased body temperature (1) • Cat Death by euthanasia (1) • Cat Death (1) • Cat Deafness (1) • Cat Bone marrow suppression (1) • Cat Balance problem (1) • Cat Application site lesion (1) • Cat Anisocoria (1) • Cat Anaemia NOS (1) • Cat Abnormal radiograph finding (1) • Cat Abnormal posture NOS (1) • Dog Abnormal cytology (1) • Cat

Showing top 5 for Other.

Data source: FDA openFDA Animal & Veterinary adverse event reports.

Adverse Event Case Summaries (openFDA)

These are individual FDA adverse event reports. They are unverified and do not prove the medication caused the reaction.

Dog, Terrier (unspecified), Male, 18 week, 0.907 kilogram • Drug: MSK, Solution, Topical, Dose: 1 dose per animal • Reactions: Tiredness (lethargy), Vomiting • Outcome: Ongoing

Report ID: USA-USFDACVM-2025-US-075431
Serious AE: No
Treated For AE: No
Sex: Male
Age: 18.00 Week
Weight: 0.907 Kilogram

Case-reported brand: MSK
Case-reported manufacturer: MSK
Route: Topical
Form: Solution
Dose: 1 dose per animal

Reactions Reported:

Tiredness (lethargy) Vomiting

Outcomes: Ongoing

Cat, Domestic Shorthair, Female, 5 year, 5.4 kilogram • Drug: MSK, Solution, Topical, Dose: 45 Milligram per animal • Reactions: Tiredness (lethargy), Diarrhea, Vomiting, Increased drinking, Fever • Outcome: Recovered/Normal

Report ID: USA-USFDACVM-2025-US-074428
Serious AE: Yes
Treated For AE: Yes
Sex: Female
Age: 5.00 Year
Weight: 5.400 Kilogram

Case-reported brand: MSK
Case-reported manufacturer: MSK
Route: Topical
Form: Solution
Dose: 45 Milligram per animal

Reactions Reported:

Tiredness (lethargy) Diarrhea Vomiting Increased drinking Fever

Outcomes: Recovered/Normal

Dog, Dachshund - Miniature, Male, 18 week, 1.814 kilogram • Drug: MSK, Solution, Topical, Dose: 15 Milligram per animal, Frequency: 1 per month • Reactions: Lack of efficacy (endoparasite) - hookworm, Medication error NOS • Outcome: Ongoing

Report ID: USA-USFDACVM-2025-US-074351
Serious AE: Yes
Treated For AE: Yes
Sex: Male
Age: 18.00 Week
Weight: 1.814 Kilogram

Case-reported brand: MSK
Case-reported manufacturer: MSK
Route: Topical
Form: Solution
Dose: 15 Milligram per animal
Frequency: 1 per month

Reactions Reported:

Lack of efficacy (endoparasite) - hookworm Medication error NOS

Outcomes: Ongoing

Dog, Retriever - Labrador, Male • Drug: MSK, Solution, Unknown • Reactions: Lack of efficacy (endoparasite) - heartworm • Outcome: Outcome Unknown

Report ID: USA-USFDACVM-2025-US-075286
Serious AE: Yes
Treated For AE: No
Sex: Male

Case-reported brand: MSK
Case-reported manufacturer: MSK
Route: Unknown
Form: Solution

Reactions Reported:

Lack of efficacy (endoparasite) - heartworm

Outcomes: Outcome Unknown

Cat, American Shorthair, Female, 4.83 year, 4.5 kilogram • Drug: MSK, Unknown, Frequency: 1 per month • Reactions: Not eating, Walking difficulty, Falling, Unable to stand, Anisocoria… • Outcome: Ongoing

Report ID: USA-USFDACVM-2025-US-074692
Serious AE: No
Treated For AE: No
Sex: Female
Age: 4.83 Year
Weight: 4.500 Kilogram

Case-reported brand: MSK
Case-reported manufacturer: MSK
Route: Unknown
Frequency: 1 per month

Reactions Reported:

Not eating Walking difficulty Falling Unable to stand Anisocoria Third eyelid protrusion

Outcomes: Ongoing

Cat, Domestic Longhair, Female, 7 week, 0.39 kilogram • Drug: MSK, Solution, Topical, Dose: 1 dose per animal • Reactions: Death, Tiredness (lethargy), Reluctant to move, Decreased body temperature, Hypoglycaemia… • Outcome: Died

Report ID: USA-USFDACVM-2025-US-074336
Serious AE: Yes
Treated For AE: Yes
Sex: Female
Age: 7.00 Week
Weight: 0.390 Kilogram

Case-reported brand: MSK
Case-reported manufacturer: MSK
Route: Topical
Form: Solution
Dose: 1 dose per animal

Reactions Reported:

Death Tiredness (lethargy) Reluctant to move Decreased body temperature Hypoglycaemia Decreased packed cell volume Head down Nystagmus

Outcomes: Died

Cat, Maine Coon, Female, 19 year, 4.59 kilogram • Drug: MSK, Solution, Topical, Frequency: 1 per month • Reactions: Chewing - pruritus, Peripheral neuropathy • Outcome: Ongoing

Report ID: USA-USFDACVM-2025-US-074273
Serious AE: Yes
Treated For AE: Yes
Sex: Female
Age: 19.00 Year
Weight: 4.590 Kilogram

Case-reported brand: MSK
Case-reported manufacturer: MSK
Route: Topical
Form: Solution
Frequency: 1 per month

Reactions Reported:

Chewing - pruritus Peripheral neuropathy

Outcomes: Ongoing

Dog, Terrier - Yorkshire, Female, 2 month, 0.395 kilogram • Drug: MSK, Solution, Topical, Dose: 1 dose per animal • Reactions: Shaking, Drooling, Tiredness (lethargy), Head tremor, Unsteady walking (ataxia)… • Outcome: Ongoing

Report ID: USA-USFDACVM-2025-US-074155
Serious AE: Yes
Treated For AE: Yes
Sex: Female
Age: 2.00 Month
Weight: 0.395 Kilogram

Case-reported brand: MSK
Case-reported manufacturer: MSK
Route: Topical
Form: Solution
Dose: 1 dose per animal

Reactions Reported:

Shaking Drooling Tiredness (lethargy) Head tremor Unsteady walking (ataxia) Not eating Not drinking Dry mucous membrane Eosinophilia Thrombocytosis Elevated gamma-glutamyl transferase Hypoglycaemia Hypokalaemia Seizure NOS

Outcomes: Ongoing

Data source: FDA openFDA Animal & Veterinary adverse event reports.

Overdose Information

No approved overdose-management text is linked yet. If overdose is suspected, contact a veterinarian or emergency clinic immediately.

Storage & Handling

No approved storage guidance is linked yet for this ingredient. Use manufacturer packaging and veterinary guidance for handling/storage.

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Medical Disclaimer: The medication details provided on Roxee are for informational purposes only and are not a substitute for professional veterinary advice. Always consult your veterinarian about your pet's specific needs.

Selamectin

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Selamectin

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Selamectin

Indications / Uses

Warnings / Contraindications

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FAQ

What species is this commonly shown for?

Does this usually require a prescription?

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Medication Research Insights

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Reaction signal map

Species and breed lens

What your vet may verify

What to watch next

Evidence

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Reported case explorer

USA-USFDACVM-2025-US-074692

USA-USFDACVM-2025-US-074155

USA-USFDACVM-2025-US-071642

USA-USFDACVM-2025-US-064137

USA-USFDACVM-2025-US-065693

Grouped by Body System

Most Reported Reactions

Source Documents

Owner handouts

Official label / PI

SPL

FOI

CIS SENERGY A200670G0003.pdf

CIS SELARID A200663G0001.pdf

CIS SELASPOT A200696A0000-2.pdf

PI SENERGY A200670G0003.pdf

Package Insert SELARID A200663G0001.pdf

REVOLT A200673G0003.pdf

REVOLT A200673G0003.pdf

Final Version REVOLUTION N141152C0093.pdf

Final Version REVOLUTION N141152C0093.pdf

PI SELASPOT A200696A0000.pdf

Selamectin

Selamectin

Dogs (6 Weeks of Age or Older)

Cats (8 Weeks of Age and Older)

SENERGY™

SENERGY™

Dogs

Cats

Selarid®

Selarid®

Dogs 6 weeks of age and older

Cats 8 weeks of age and older

Revolt®

Revolt®

Dogs

Cats

Revolution®

Revolution®

Cats (8 Weeks of Age and Older)

Dogs (6 Weeks of Age or Older)

SelaSpot™

SelaSpot™

Dogs

Cats

Selamectin SPL

REVOLUTION SPL

Selamectin SPL