Roxee Meds Catalog

Sevoflurane

Medication catalog facts with explicit FDA-approval, off-label, source-limited, and safety context.

Both Catalog complete FDA data linked Rx required Liquid Multiple FDA labelers Official label facts Owner quick guide first

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Data freshness

Storefront facts

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May 5, 2026, 10:00 a.m.

These are the storefront facts Roxee uses on browse cards and quick facts.

FDA applications

FDA application data refreshed

May 5, 2026, 10:00 a.m.

Sponsor, product, and application records imported from Animal Drugs @ FDA.

Safety reports

Safety data refreshed

May 5, 2026, 10:01 a.m.

openFDA reaction terms and case summaries are supporting evidence, not proof of causality.

Source timing details

Storefront facts: Source Roxee | Refreshed May 5, 2026, 10:00 AM UTC
The storefront fact projection used for browse cards and quick facts.
Animal Drugs @ FDA: Source FDA | Refreshed May 5, 2026, 10:00 AM UTC
Applications/products are imported from FDA export data.
Animal Drugs @ FDA previews: Source FDA | Refreshed Feb 9, 2026, 3:05 AM UTC
Label highlights/doc links are fetched from FDA preview endpoints.
Animal Drug Product Listing Directory (NDC): Source FDA | Refreshed May 5, 2026, 10:00 AM UTC
Package/product NDCs from FDA’s electronic listing directory (XLS).
openFDA reaction terms: Source FDA openFDA | Refreshed May 5, 2026, 10:04 AM UTC
openFDA case summaries: Source FDA openFDA | Refreshed May 5, 2026, 10:04 AM UTC

Evidence

Reviewed / Updated / Sources

Reviewed by: Not available

Last reviewed: February 12, 2026

Updated: February 12, 2026, 10:44 PM UTC

Sources:

FDA application profile · official_label
FDA application profile · official_label
Medication usage source · fda_animal_drugs
Sevospire™ · official_label
openFDA case USA-USFDACVM-2025-US-054707 · adverse_reaction

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Sevoflurane

Drug type: Generic ingredient • Branded profile • FDA branded products available

Both Liquid Rx required 100% storefront ready

Species: Both

Manufacturer: Multiple FDA labelers

Medication Snapshot

Merged from the current Roxee medication system with field-level provenance, freshness, and completeness tracking.

Sevoflurane

SevoFlo is indicated for induction and maintenance of general anesthesia in dogs. For induction and maintenance of general anesthesia in dogs. Species commonly shown: Both, Dog, No Use Class Stated Or Implied.

Generic name

Sevoflurane

Brand names

SevoFlo®, Petrem®, Sevospire™, Sevoflurane

Manufacturer

Multiple FDA labelers

Species

Both, Dog, No Use Class Stated Or Implied

Dosage forms

Liquid, Liquid (Solution)

Prescription

Prescription required

Completeness

100%

Validation

Complete

Brand names

SevoFlo® Petrem® Sevospire™ Sevoflurane FlurovessTM Petrem SevoFlo Sevospire

Dosage forms

Liquid Liquid (Solution)

Indications / Uses

SevoFlo is indicated for induction and maintenance of general anesthesia in dogs. For induction and maintenance of general anesthesia in dogs.

Warnings / Contraindications

Federal law restricts this drug to use by or on the order of a licensed veterinarian. When using sevoflurane, patients should be continuously monitored and facilities for maintenance of patent airway, artificial ventilation, and oxygen supplementation must be immediately available Federal law restricts this drug to use by or on the order of a licensed veterinarian.

Federal law restricts this drug to use by or on the order of a licensed veterinarian. When using sevoflurane, patients should be continuously monitored and facilities for maintenance of patent airway, artificial ventilation, and oxygen supplementation must be immediately available Federal law restricts this drug to use by or on the order of a licensed veterinarian.

Side Effects

Top reported reactions (openFDA): Vomiting, Death, Lethargy (see also Central nervous system depression in 'Neurological'), Bradycardia, Diarrhoea, Lack of efficacy - NOS.

FAQ

Both, Dog, No Use Class Stated Or Implied

Yes. Roxee shows this as prescription-only.

Liquid, Liquid (Solution)

Source Transparency

Verified source: https://www.roxee.ai/meds/
Verified source: https://animaldrugsatfda.fda.gov
Verified source: https://animaldrugsatfda.fda.gov/adafda/views/#/search
Verified source: https://api.fda.gov/animalandveterinary/event.json
Verified source: https://animaldrugsatfda.fda.gov/adafda/app/search/public/document/downloadFoi/635
Verified source: https://www.accessdata.fda.gov/spl/data/acec1737-69e5-43b6-a5c4-024da78722a7/acec1737-69e5-43b6-a5c4-024da78722a7.xml
Last refreshed: May 5, 2026, 10:00 a.m.
Last verified: Feb 12, 2026, 10:44 p.m.
Validation status: Complete

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Pet Owner Quick Guide

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Used for:

For induction and maintenance of general anesthesia in dogs.

Dosing note:

Exact dosing depends on your pet's species, weight, and health status. Use your veterinarian's instructions for the exact dose and schedule.

What to watch for:

trouble breathing (1 reports)
Loss of appetite (1 reports)
Focal seizure (1 reports)

When to call the vet:

Repeated vomiting or diarrhea.
Severe lethargy (hard to wake, very low energy).
Collapse or fainting.
Facial swelling or hives.
Blood in vomit or stool.

Regulatory restrictions are shown in Vet View.

What to tell or ask your vet today:

Is this medicine the right fit for my pet’s current symptoms?
Which warning signs mean I should call back right away?
How should I handle missed doses or refusal to take the medicine?

Major cautions & emergency warning signs

Side effects to monitor:

trouble breathing
Loss of appetite
Focal seizure

Most reported reactions:

Trouble breathing (dyspnea) (1 reports)
Loss of appetite (1 reports)
Focal seizure (1 reports)

Emergency warning signs:

Repeated vomiting or diarrhea.
Severe lethargy (hard to wake, very low energy).
Collapse or fainting.
Facial swelling or hives.

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Quick Facts

Official label facts first, then secondary summaries. Marketing content is separated below.

Species: Both

Manufacturer: Multiple FDA labelers

Form: Liquid, Liquid (Solution)

Identifiers:

ANADA: 200438 ANADA: 200467 ANADA: 200830 NADA: 141103 NDC Package: 11695-0505-2 NDC Package: 13985-711-25 NDC Package: 17033-092-25 NDC Package: 46066-116-04 NDC Package: 54771-5458-2 NDC Package: 66794-018-10 NDC Package: 66794-018-25 NDC Package: 68504-011-01 NDC Product: 11695 NDC Product: 13985 NDC Product: 17033 NDC Product: 46066 NDC Product: 54771 NDC Product: 66794 NDC Product: 68504

Source metadata:

https://animaldrugsatfda.fda.gov/adafda/views/#/home/previewsearch/200830 · official_label · FDA application profile
https://animaldrugsatfda.fda.gov/adafda/views/#/home/previewsearch/200438 · official_label · FDA application profile
https://animaldrugsatfda.fda.gov · fda_animal_drugs · Medication usage source

Warnings / Contraindications

High: Federal law restricts this drug to use by or on the order of a licensed veterinarian. When using sevoflurane, patients should be continuously monitored and facilities for maintenance of patent airway, artificial ventilation, and oxygen supplementation must be immediately available Federal law restricts this drug to use by or on the order of a licensed veterinarian.

Source metadata:

https://animaldrugsatfda.fda.gov · fda_animal_drugs · Contraindication source

Adverse Reactions

Snapshot first, detailed rows second. This section summarizes signal data and is not a diagnosis.

Tap or hover a reaction to see what it means in plain language.

Tracked signals

Reported cases

Serious reports

Species represented

Grouped by Body System

Digestive (4) · Loss of appetite, Diarrhea, Decreased appetite Skin & allergy (1) · Hair loss at application site Neurologic (2) · Focal seizure, Depression Other (25) · Trouble breathing (dyspnea), Fear/fearful, Excessive chewing, licking and/or grooming

Most Reported Reactions

Body system	Cases	Species	Serious cases
Other	1	Dog	1
Digestive	1	Dog	1
Neurologic	1	Cat	1
Other	1	Dog	1
Other	1	Dog	1
Neurologic	1	Dog	1
Other	1	Dog	1
Other	1	Dog	1

Species coverage: Dog (19) Cat (13)

View detailed reaction table

Body system	Species	Seriousness	Frequency	Reports
Other	Dog	Serious	-	1
Digestive	Dog	Serious	-	1
Skin & allergy	Cat	Non-serious	-	1
Neurologic	Cat	Serious	-	1
Other	Cat	Non-serious	-	1
Other	Dog	Serious	-	1
Other	Dog	Serious	-	1
Other	Cat	Non-serious	-	1
Other	Cat	Non-serious	-	1
Digestive	Cat	Non-serious	-	1
Neurologic	Dog	Serious	-	1
Other	Dog	Serious	-	1
Other	Cat	Non-serious	-	1
Other	Dog	Serious	-	1
Digestive	Dog	Serious	-	1
Other	Cat	Serious	-	1
Other	Dog	Serious	-	1
Other	Dog	Serious	-	1
Other	Dog	Serious	-	1
Other	Cat	Non-serious	-	1
Other	Cat	Non-serious	-	1
Other	Cat	Non-serious	-	1
Other	Dog	Serious	-	1
Other	Cat	Non-serious	-	1
Other	Cat	Non-serious	-	1
Digestive	Dog	Serious	-	1
Other	Dog	Non-serious	-	1
Other	Dog	Serious	-	1
Other	Dog	Serious	-	1
Other	Dog	Serious	-	1
Other	Dog	Non-serious	-	1
Other	Dog	Serious	-	1

Source metadata:

https://api.fda.gov/animalandveterinary/event.json · adverse_reaction · openFDA case USA-USFDACVM-2025-US-054707

Documents

Owner handouts and official technical documents open on-page first, with the original source still one click away.

Owner handouts

No owner handouts linked yet.

Official label / PI

No official label or package insert links yet.

SPL

FOI

Sevoflurane

SPL · SPL

Open original

FDA Structured Product Label

Sevoflurane

Rendered from Roxee's cached FDA SPL package contents for on-page reading. Use Open original for the raw FDA ZIP/XML source.

Sponsor: Parnell Technologies Pty. Ltd.
ANADA: 200-830
Status: RX
Form: Liquid
Route: Inhalation

Composition / specifications

250 mL sevoflurane

Dogs

Indication

For induction and maintenance of general anesthesia in dogs.

Dosage

For induction of surgical anesthesia: up to 7 percent sevoflurane. For maintenance of surgical anesthesia: 3.7 to 4percent sevoflurane with oxygen in the absence of premedication and 3.3 to 3.6 percent in the presence of premedication.

Petrem®

SPL · SPL

Open original

FDA Structured Product Label

Petrem®

Rendered from Roxee's cached FDA SPL package contents for on-page reading. Use Open original for the raw FDA ZIP/XML source.

Sponsor: Piramal Pharma Ltd.
ANADA: 200-438
Status: RX
Form: Liquid (Solution)
Route: Inhalation
Species: Dog, No Use Class Stated Or Implied

Label highlights

Indication

For induction and maintenance of general anesthesia in dogs.

Dosage

For induction of surgical anesthesia: Up to 7 percent sevoflurane with oxygen. For maintenance of surgical anesthesia: 3.7 to 4 percent sevoflurane with oxygen in the absence of premedication and 3.3 to 3.6 percent in the presence of premedication

Limitations

Federal law restricts this drug to use by or on the order of a licensed veterinarian.

Sevospire™

SPL · SPL

Open original

FDA Structured Product Label

Sevospire™

Rendered from Roxee's cached FDA SPL package contents for on-page reading. Use Open original for the raw FDA ZIP/XML source.

Sponsor: Dechra Veterinary Products LLC
ANADA: 200-467
Status: RX
Form: Liquid
Route: Inhalation
Species: Dog, No Use Class Stated Or Implied

Composition / specifications

250 mL sevoflurane

Dogs

Indication

For induction and maintenance of general anesthesia in dogs.

Dosage

Induction: For mask induction using Sevoflurane alone, inspired concentrations of up to 7% sevoflurane with oxygen are employed to induce surgical anesthesia in the healthy dog. Maintenance: Surgical levels of anesthesia in the healthy dog may be maintained with inhaled concentrations of 3.7-4.0% sevoflurane in oxygen in the absence of premedication and 3.3-3.6% in the presence of premedication.

Limitations

Federal law restricts this drug to use by or on the order of a licensed veterinarian.

SevoFlo®

SPL · SPL

Open original

FDA Structured Product Label

SevoFlo®

Rendered from Roxee's cached FDA SPL package contents for on-page reading. Use Open original for the raw FDA ZIP/XML source.

Sponsor: Zoetis Inc.
NADA: 141-103
Status: RX
Form: Liquid
Route: Inhalation
Species: Dog, No Use Class Stated Or Implied

Dogs

Indication

SevoFlo is indicated for induction and maintenance of general anesthesia in dogs.

Dosage

For induction of surgical anesthesia: Up to 7 percent sevoflurane with oxygen. For maintenance of surgical anesthesia: 3.7 to 4 percent sevoflurane with oxygen in the absence of premedication and 3.3 to 3.6 percent in the presence of premedication.

Limitations