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Roxee Medication Guide

Sevoflurane

Medication reference facts with explicit FDA-approval, off-label, source-limited, and safety context. Roxee does not sell, prescribe, or dispense medications.

Both Reference complete FDA data linked Rx required Liquid Multiple FDA labelers Official label facts Owner quick guide first
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Data freshness

Reference facts
Reference refreshed
Aug 6, 2026, 7:47 p.m.

These are the reference facts Roxee uses on browse cards and quick facts.

FDA applications
FDA application data refreshed
Aug 6, 2026, 7:47 p.m.

Sponsor, product, and application records imported from Animal Drugs @ FDA.

Safety reports
Safety data refreshed
Aug 6, 2026, 7:49 p.m.

openFDA reaction terms and case summaries are supporting evidence, not proof of causality.

Source timing details
Source timing details
  • Reference facts: Source Roxee | Refreshed Aug 6, 2026, 7:47 PM UTC
    The reference fact projection used for browse cards and quick facts.
  • Animal Drugs @ FDA: Source FDA | Refreshed Aug 6, 2026, 7:47 PM UTC
    Applications/products are imported from FDA export data.
  • Animal Drugs @ FDA previews: Source FDA | Refreshed Feb 9, 2026, 3:05 AM UTC
    Label highlights/doc links are fetched from FDA preview endpoints.
  • Animal Drug Product Listing Directory (NDC): Source FDA | Refreshed Aug 6, 2026, 7:47 PM UTC
    Package/product NDCs from FDA’s electronic listing directory (XLS).
  • openFDA reaction terms: Source FDA openFDA | Refreshed Aug 6, 2026, 7:52 PM UTC
  • openFDA case summaries: Source FDA openFDA | Refreshed Aug 6, 2026, 7:52 PM UTC
Illustration placeholder
Sevoflurane

Sevoflurane

Drug type: Generic ingredient • Branded profile • FDA branded products available

Both Liquid Rx required 100% reference complete

Species: Both

Manufacturer: Multiple FDA labelers

Medication Snapshot

Merged from the current Roxee medication system with field-level provenance, freshness, and completeness tracking.

Sevoflurane

SevoFlo is indicated for induction and maintenance of general anesthesia in dogs. For induction and maintenance of general anesthesia in dogs. Species commonly shown: Both, Dog.

Generic name
Sevoflurane
Brand names
SevoFlo®, Petrem®, Sevospire™, Sevoflurane
Manufacturer
Multiple FDA labelers
Species
Both, Dog
Dosage forms
Liquid, Liquid (Solution)
Prescription
Prescription required
Completeness
100%
Validation
Complete
Brand names
SevoFlo® Petrem® Sevospire™ Sevoflurane FlurovessTM Petrem SevoFlo Sevospire
Dosage forms
Liquid Liquid (Solution)

Indications / Uses

SevoFlo is indicated for induction and maintenance of general anesthesia in dogs. For induction and maintenance of general anesthesia in dogs.

Warnings / Contraindications

Federal law restricts this drug to use by or on the order of a licensed veterinarian. When using sevoflurane, patients should be continuously monitored and facilities for maintenance of patent airway, artificial ventilation, and oxygen supplementation must be immediately available Federal law restricts this drug to use by or on the order of a licensed veterinarian.

  • Federal law restricts this drug to use by or on the order of a licensed veterinarian. When using sevoflurane, patients should be continuously monitored and facilities for maintenance of patent airway, artificial ventilation, and oxygen supplementation must be immediately available Federal law restricts this drug to use by or on the order of a licensed veterinarian.

Side Effects

Top reported reactions (openFDA): Vomiting, Death, Lethargy (see also Central nervous system depression in 'Neurological'), Bradycardia, Diarrhoea, Lack of efficacy - NOS.

FAQ

Both, Dog

Yes. Roxee shows this as prescription-only.

Liquid, Liquid (Solution)

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Pet Owner Quick Guide

Start here first for the safest next-step summary before the deeper medication detail.

Used for:

For induction and maintenance of general anesthesia in dogs.

Dosing note:

Exact dosing depends on your pet's species, weight, and health status. Use your veterinarian's instructions for the exact dose and schedule.

What to watch for:

  • wobbly/unsteady walking (1 reports)
  • Loss of appetite (1 reports)
  • Arthritis (1 reports)

When to call the vet:

  • Repeated vomiting or diarrhea.
  • Severe lethargy (hard to wake, very low energy).
  • Collapse or fainting.
  • Trouble breathing.
  • Facial swelling or hives.
  • Blood in vomit or stool.

Regulatory restrictions are shown in Vet View.

What to tell or ask your vet today:

  • Is this medicine the right fit for my pet’s current symptoms?
  • Which warning signs mean I should call back right away?
  • How should I handle missed doses or refusal to take the medicine?

Next actions

Talk to a Vet / Find a Vet Near You Save to pet meds Share page Review report evidence
Research brief

Medication Research Insights

A source-aware map of what to know, what is uncertain, and what to verify with your veterinarian.

Source Backed Signals

What to know

Evidence-backed context Limited

Roxee has limited cited overview evidence for Sevoflurane; use the official documents and your veterinarian's instructions for product-specific decisions.

Source: openFDA case NOR-USFDACVM-2026-NO-000001
Safety signal coverage Reported signals

32 tracked reaction signals; 32 reported cases; 21 serious reports; 2 species groups. These are reporting and label-derived signals for interpretation with a veterinarian.

Source: openFDA case NOR-USFDACVM-2026-NO-000001
Interpretation guardrail Not causation

Adverse-event reports help form a watch list, but they do not prove the medication caused the reaction and they are not a risk ranking between medications.

Evidence tension

Stronger signal Label / review

Official labels, package inserts, and reviewed summaries carry more weight than isolated reports.

Source: openFDA case NOR-USFDACVM-2026-NO-000001
Weaker signal Reported data

Case reports and openFDA terms are useful for pattern awareness, but they are incomplete, can include multiple exposures, and do not estimate an individual pet's probability of harm.

Reaction signal map

Most reported reactions Top terms

Unsteady walking (ataxia) (1 reports), Loss of appetite (1 reports), Arthritis (1 reports), Application site pustule (1 reports), Appetite loss (1 reports)

Body systems represented Signal grouping

Digestive (2), Skin & allergy (3), Neurologic (1), Behavior (1)

Explore supporting adverse reports

Species and breed lens

Species represented in reports Species lens

Dog (20 reports), Cat (12 reports)

Breed metadata in reports Metadata only

Siamese (2), Domestic Shorthair (2), ['Siberian', 'Crossbred Feline/cat'] (1), Bulldog - English (1). These are report metadata, not proof that a breed is at higher risk.

What your vet may verify

Fit for this patient Vet check

Verify whether Sevoflurane fits the pet's species, current diagnosis, age, weight, organ status, pregnancy/lactation status, and concurrent medications.

Evidence limitations Evidence review

Separate label-backed warnings from adverse-event reports and owner observations before changing the plan.

What to watch next

Watch list Owner-safe

wobbly/unsteady walking, Loss of appetite, Arthritis

Call sooner if Escalation

Repeated vomiting or diarrhea. Severe lethargy (hard to wake, very low energy). Collapse or fainting.

Bottom line: Use this Sevoflurane brief as a structured watch list and source map, not as a reason to start, stop, or change treatment without your veterinarian.
Vet source depth
  1. openFDA case NOR-USFDACVM-2026-NO-000001 · adverse_reaction · adverse reactions
  2. Contraindication source · fda_animal_drugs · warnings contraindications
  3. FDA application profile · official_label · quick facts
  4. FDA application profile · official_label · quick facts
  5. Medication usage source · fda_animal_drugs · quick facts
  6. FOI · document · documents
  7. SPL · document · documents
  8. FOI · document · documents

Evidence

Review status / Updated / Sources

Review status: Clinical reviewer not listed

Updated: February 12, 2026, 10:44 PM UTC

Sources:
Safety & side effects

Side effects to monitor:

  • wobbly/unsteady walking
  • Loss of appetite
  • Arthritis

Most reported reactions:

  • Unsteady walking (ataxia) (1 reports)
  • Loss of appetite (1 reports)
  • Arthritis (1 reports)
Explore reported case details

Emergency warning signs:

  • Repeated vomiting or diarrhea.
  • Severe lethargy (hard to wake, very low energy).
  • Collapse or fainting.
  • Trouble breathing.
Talk to a Vet / Find a Vet Near You Start Symptom Intake

Vet Fast Scan

Source-backed clinical checkpoints for quick review.

FDA-labeled species
Dog
Indication / use
For induction and maintenance of general anesthesia in dogs.
Form / route / dose
Form: Liquid, Liquid (Solution)
Route: Inhalation
Confirm product label and patient-specific plan.
Warnings
  • High: Federal law restricts this drug to use by or on the order of a licensed veterinarian. When using sevoflurane, patients …
Adverse-event caveat
openFDA adverse-event cases are reported signals. They are not verified, do not prove causation, and do not estimate a pet's individual risk.
Source docs

Quick Facts

Official label facts first, then secondary summaries. Marketing content is separated below.

Species: Both
Manufacturer: Multiple FDA labelers
Form: Liquid, Liquid (Solution)
Identifiers:
ANADA: 200438 ANADA: 200467 ANADA: 200830 NADA: 141103 NDC Package: 11695-0505-2 NDC Package: 13985-711-25 NDC Package: 17033-092-25 NDC Package: 46066-116-04 NDC Package: 54771-5458-2 NDC Package: 66794-018-10 NDC Package: 66794-018-25 NDC Package: 68504-011-01 NDC Product: 11695 NDC Product: 13985 NDC Product: 17033 NDC Product: 46066 NDC Product: 54771 NDC Product: 66794 NDC Product: 68504
Source metadata:

Warnings / Contraindications

Federal law restricts this drug to use by or on the order of a licensed veterinarian. When using sevoflurane, patients should be continuously monitored and facilities for maintenance of patent airway, artificial ventilation, and oxygen supplementation must be immediately available Federal law restricts this drug to use by or on the order of a licensed veterinarian.

  • High: Federal law restricts this drug to use by or on the order of a licensed veterinarian. When using sevoflurane, patients should be continuously monitored and facilities for maintenance of patent airway, artificial ventilation, and oxygen supplementation must be immediately available Federal law restricts this drug to use by or on the order of a licensed veterinarian.
Source metadata:

Adverse Reactions

Snapshot first, detailed rows second. This section summarizes signal data and is not a diagnosis.

Reported case explorer

Filter stored openFDA reports by pet and report attributes. Counts describe reports in this data set, not risk.

Clear filters
openFDA adverse-event cases are reported signals. They are not verified, do not prove causation, and do not estimate a pet's individual risk.
Stored reports
16
Matching reports
3
Active filters
2
Selected filters
Reaction: Abnormal ultrasound finding Clear Body system: Digestive Clear
Reset
Drill into common report signals
Lethargy (see also Central nervous system depression in Neurological) (7) Anorexia (4) Vomiting (4) Abnormal ultrasound finding (3) Other (16) Digestive (10) Neurologic (9) Skin & allergy (5)
Showing up to 50 matching reports.

NOR-USFDACVM-2026-NO-000003

Received 2026-02-16 · MSK · MSK

Serious
Species
Dog
Breed
Bulldog - English
Size / weight
25-49 lb (20.1 Kilogram)
Age
8+ years (1 Year)
Sex
Female Neutered
Region
USA
Reactions
DyspnoeaPale mucous membraneElevated C-reactive proteinLethargy (see also Central nervous system depression in Neurological)VomitingAnaemia NOSLeukocytosis NOSAnorexiaRegurgitationWeaknessProlonged capillary refill timeTachycardiaWeak pulseAbnormal breathingHypovolaemic shockAbnormal ultrasound findingGastric ulcerPeritonitisAbdominal effusionImpaired gastric functionDeath by euthanasia
Body systems
OtherNeurologicDigestive
Outcomes
Euthanized

NOR-USFDACVM-2026-NO-000002

Received 2026-02-16 · MSK · MSK

Serious
Species
Dog
Breed
Retriever - Labrador
Size / weight
50-99 lb (29.8 Kilogram)
Age
8+ years (9 Year)
Sex
Female Intact
Region
USA
Reactions
RestlessnessVocalisationPain NOSDullSubduedUncomfortableMelaenaAbdominal painAnorexiaDecreased red blood cell countDecreased haematocritDecreased haemoglobinDecreased mean corpuscular volume (MCV)Decreased percentage of reticulocytesThrombocytopeniaHypoproteinaemiaAbnormal ultrasound findingAbdominal effusionFeverTachycardiaHyperaemic mucous membraneAbdominal exudatePeritoneal fluid, high white blood cell countGastric ulcerLow thyroxine (T4)Low free thyroxine (FT4)Death by euthanasia
Body systems
OtherDigestive
Outcomes
Euthanized

NOR-USFDACVM-2026-NO-000001

Received 2026-02-16 · MSK · MSK

Serious
Species
Dog
Breed
Dog (other)
Size / weight
50-99 lb (24 Kilogram)
Age
8+ years (9 Year)
Sex
Male Unknown
Region
USA
Reactions
HypernatraemiaHyperkalaemiaLow thyroxine (T4)Low free thyroxine (FT4)DiarrhoeaVomitingNot himself/herselfAnorexiaLethargy (see also Central nervous system depression in Neurological)PantingWeight lossTachycardiaWeak pulseFeverAbdominal discomfortElevated C-reactive proteinAnaemia NOSDecreased haematocritDecreased haemoglobinDecreased mean corpuscular haemoglobin concentration (MCHC)Decreased red cell distribution width (RDW)Other abnormal test result NOSNeutrophiliaMonocytosisHypoalbuminaemiaAbnormal ultrasound findingGastric ulcerPeritonitisBlood in faecesMelaenaBloody diarrhoea
Body systems
OtherDigestiveNeurologic
Outcomes
Recovered/Normal

Tap or hover a reaction to see what it means in plain language.

Tracked signals
32
Reported cases
32
Serious reports
21
Species represented
2
Grouped by Body System
Digestive (2) · Loss of appetite, Appetite loss Skin & allergy (3) · Hair loss at application site, Application site hair loss, Alopecia general Neurologic (1) · Unsteady walking (ataxia) Behavior (1) · Anxiety Other (25) · Arthritis, Application site ulcer, Application site scratching
Most Reported Reactions
Reaction Body system Cases Species Serious cases
Neurologic 1 Cat 1
Digestive 1 Dog 1
Other 1 Dog 1
Other 1 Dog 1
Digestive 1 Dog 1
Behavior 1 Dog 1
Other 1 Cat 1
Other 1 Dog 1

Species coverage: Dog (20) Cat (12)

View detailed reaction table
Reaction Body system Species Seriousness Frequency Reports
Neurologic Cat Serious - 1
Digestive Dog Serious - 1
Skin & allergy Cat Non-serious - 1
Other Dog Serious - 1
Other Cat Non-serious - 1
Other Cat Non-serious - 1
Other Cat Non-serious - 1
Other Cat Non-serious - 1
Other Dog Serious - 1
Other Cat Non-serious - 1
Skin & allergy Cat Non-serious - 1
Other Cat Non-serious - 1
Other Cat Non-serious - 1
Digestive Dog Serious - 1
Behavior Dog Serious - 1
Other Cat Serious - 1
Other Dog Serious - 1
Skin & allergy Dog Serious - 1
Other Dog Serious - 1
Other Dog Non-serious - 1
Other Cat Serious - 1
Other Dog Serious - 1
Other Dog Serious - 1
Other Dog Serious - 1
Other Dog Serious - 1
Other Dog Non-serious - 1
Other Dog Serious - 1
Other Dog Serious - 1
Other Dog Serious - 1
Other Dog Serious - 1
Other Dog Serious - 1
Other Dog Serious - 1
Source metadata:

Source Documents

The most useful source links appear first; full previews and metadata stay in the veterinary/professional layer.

Use original documents to confirm product-specific warnings, ingredients, and handling details with your veterinarian.

Sevoflurane SPL · SPL Petrem® SPL · SPL Sevospire™ SPL · SPL

Full source previews and metadata remain in the veterinary/professional layer.

Owner handouts

0
No owner handouts linked yet.

Official label / PI

0
No official label or package insert links yet.

SPL

11

FOI

4

Sevoflurane

SPL · SPL

Open original
FDA Structured Product Label

Sevoflurane

Rendered from Roxee's cached FDA SPL package contents for on-page reading. Use Open original for the raw FDA ZIP/XML source.

Sponsor
Parnell Technologies Pty. Ltd.
ANADA
200-830
Status
RX
Form
Liquid
Route
Inhalation
Composition / specifications
250 mL sevoflurane

Dogs

Indication

For induction and maintenance of general anesthesia in dogs.

Dosage

For induction of surgical anesthesia: up to 7 percent sevoflurane. For maintenance of surgical anesthesia: 3.7 to 4percent sevoflurane with oxygen in the absence of premedication and 3.3 to 3.6 percent in the presence of premedication.

Petrem®

SPL · SPL

Open original
FDA Structured Product Label

Petrem®

Rendered from Roxee's cached FDA SPL package contents for on-page reading. Use Open original for the raw FDA ZIP/XML source.

Sponsor
Piramal Pharma Ltd.
ANADA
200-438
Status
RX
Form
Liquid (Solution)
Route
Inhalation
Species
Dog

Label highlights

Indication
For induction and maintenance of general anesthesia in dogs.
Dosage
For induction of surgical anesthesia: Up to 7 percent sevoflurane with oxygen. For maintenance of surgical anesthesia: 3.7 to 4 percent sevoflurane with oxygen in the absence of premedication and 3.3 to 3.6 percent in the presence of premedication
Limitations
Federal law restricts this drug to use by or on the order of a licensed veterinarian.

Sevospire™

SPL · SPL

Open original
FDA Structured Product Label

Sevospire™

Rendered from Roxee's cached FDA SPL package contents for on-page reading. Use Open original for the raw FDA ZIP/XML source.

Sponsor
Dechra Veterinary Products LLC
ANADA
200-467
Status
RX
Form
Liquid
Route
Inhalation
Species
Dog
Composition / specifications
250 mL sevoflurane

Dogs

Indication
For induction and maintenance of general anesthesia in dogs.
Dosage
Induction: For mask induction using Sevoflurane alone, inspired concentrations of up to 7% sevoflurane with oxygen are employed to induce surgical anesthesia in the healthy dog. Maintenance: Surgical levels of anesthesia in the healthy dog may be maintained with inhaled concentrations of 3.7-4.0% sevoflurane in oxygen in the absence of premedication and 3.3-3.6% in the presence of premedication.
Limitations
Federal law restricts this drug to use by or on the order of a licensed veterinarian.

SevoFlo®

SPL · SPL

Open original
FDA Structured Product Label

SevoFlo®

Rendered from Roxee's cached FDA SPL package contents for on-page reading. Use Open original for the raw FDA ZIP/XML source.

Sponsor
Zoetis Inc.
NADA
141-103
Status
RX
Form
Liquid
Route
Inhalation
Species
Dog

Dogs

Indication
SevoFlo is indicated for induction and maintenance of general anesthesia in dogs.
Dosage
For induction of surgical anesthesia: Up to 7 percent sevoflurane with oxygen. For maintenance of surgical anesthesia: 3.7 to 4 percent sevoflurane with oxygen in the absence of premedication and 3.3 to 3.6 percent in the presence of premedication.
Limitations
Federal law restricts this drug to use by or on the order of a licensed veterinarian. When using sevoflurane, patients should be continuously monitored and facilities for maintenance of patent airway, artificial ventilation, and oxygen supplementation must be immediately available

Sevospire SPL

SPL · Structured Product Label

Open original
FDA Structured Product Label XML for Sevospire. Use the source link for the full official labeling record.

SevoFlo SPL

SPL · Structured Product Label

Open original
FDA Structured Product Label XML for SevoFlo. Use the source link for the full official labeling record.

Sevoflurane SPL

SPL · Structured Product Label

Open original
FDA Structured Product Label XML for Sevoflurane. Use the source link for the full official labeling record.

Sevoflurane SPL

SPL · Structured Product Label

Open original
FDA Structured Product Label XML for Sevoflurane. Use the source link for the full official labeling record.

Petrem SPL

SPL · Structured Product Label

Open original
FDA Structured Product Label XML for Petrem. Use the source link for the full official labeling record.

Sevoflurane SPL

SPL · Structured Product Label

Open original
FDA Structured Product Label XML for Sevoflurane. Use the source link for the full official labeling record.

FlurovessTM SPL

SPL · Structured Product Label

Open original
FDA Structured Product Label XML for FlurovessTM. Use the source link for the full official labeling record.

FOI Summary oA 200-830 Approved January 30, 2026.pdf

FOI · FOI

Open original

ucm061373.pdf

FOI · FOI

Open original

UCM202417.pdf

FOI · FOI

Open original

ucm117135.pdf

FOI · FOI

Open original
Source metadata:
Veterinary reference (advanced)

Canonical medication sections are above. This legacy block remains available for deeper cross-reference without cluttering the primary workflow.

At a Glance

Quick facts and links to official labeling and safety signals.

Data freshness
  • Reference facts: Source Roxee | Refreshed Aug 6, 2026, 7:47 PM UTC
    The reference fact projection used for browse cards and quick facts.
  • Animal Drugs @ FDA: Source FDA | Refreshed Aug 6, 2026, 7:47 PM UTC
    Applications/products are imported from FDA export data.
  • Animal Drugs @ FDA previews: Source FDA | Refreshed Feb 9, 2026, 3:05 AM UTC
    Label highlights/doc links are fetched from FDA preview endpoints.
  • Animal Drug Product Listing Directory (NDC): Source FDA | Refreshed Aug 6, 2026, 7:47 PM UTC
    Package/product NDCs from FDA’s electronic listing directory (XLS).
  • openFDA reaction terms: Source FDA openFDA | Refreshed Aug 6, 2026, 7:52 PM UTC
  • openFDA case summaries: Source FDA openFDA | Refreshed Aug 6, 2026, 7:52 PM UTC
Official (FDA)
Identity: Generic ingredient • FDA branded products available
Official FDA brands: FlurovessTM Petrem SevoFlo Sevoflurane Sevospire
Manufacturer mapping: Multiple FDA labelers
Case-reported brands (openFDA): MSK
Catalog species: Both • FDA-labeled species: Dog
Rx/OTC: RX
Form/route: Liquid, Liquid (Solution) • Inhalation
Applications: ANADA 200-830 • ANADA 200-438 • ANADA 200-467 • NADA 141-103
NDC: Packages 11695-0505-2 13985-711-25 17033-092-25 46066-116-04 54771-5458-2 66794-018-10 • Products 11695 13985 17033 46066 54771 66794
Documents: 4 (FOI: 4) • SPL: 4 • Label highlights • Official documents
Safety (openFDA)
Top reactions: Dog 110 • Cat 52 • View
Case summaries: 16 (showing 8) • View
openFDA reports are unverified and do not prove causation.
Diagnosis Codes

Diagnosis-code mappings are not available for this medication yet.

Counseling and Monitoring Highlights

Global Pet owner/Vet mode is controlled in the header. This section avoids duplicate in-page persona tabs.

Owner-facing counseling points
  • Federal law restricts this drug to use by or on the order of a licensed veterinarian. When using sevoflurane, patients should be continuously monitored and facilities for maintenance of patent airway, artificial ventilation, and oxygen supplementation must be immediately available Federal law restricts this drug to use by or on the order of a licensed veterinarian. (Contraindication, High)
Top reaction signals
Unsteady walking (ataxia) (1) Loss of appetite (1) Arthritis (1) Application site pustule (1) Appetite loss (1) Anxiety (1) Anaphylaxis (1) Anaemia NOS (1)

Identifiers & Packages

Normalized identifiers (NDC/NADA/ANADA) and package metadata from regulator listings.

Identifiers
ANADA: 200438 ANADA: 200467 ANADA: 200830 NADA: 141103 NDC Package: 11695-0505-2 NDC Package: 13985-711-25 NDC Package: 17033-092-25 NDC Package: 46066-116-04 NDC Package: 54771-5458-2 NDC Package: 66794-018-10 NDC Package: 66794-018-25 NDC Package: 68504-011-01 NDC Product: 11695 NDC Product: 13985 NDC Product: 17033 NDC Product: 46066 NDC Product: 54771 NDC Product: 66794 NDC Product: 68504
Package NDC Product NDC Form / Route Status
11695-0505-2 11695 -
13985-711-25 13985 -
17033-092-25 17033 -
46066-116-04 46066 -
54771-5458-2 54771 -
66794-018-10 66794 -
66794-018-25 66794 -
68504-011-01 68504 -

Enriched Documents

Documents are tiered by source trust: Official, Clinical, Manufacturer, Marketing.

  • Sevospire SPL • Structured Product Label • Official
    FDA Structured Product Label from the electronic animal drug product listing directory.
  • SevoFlo SPL • Structured Product Label • Official
    FDA Structured Product Label from the electronic animal drug product listing directory.
  • Sevoflurane SPL • Structured Product Label • Official
    FDA Structured Product Label from the electronic animal drug product listing directory.
  • Sevoflurane SPL • Structured Product Label • Official
    FDA Structured Product Label from the electronic animal drug product listing directory.
  • Petrem SPL • Structured Product Label • Official
    FDA Structured Product Label from the electronic animal drug product listing directory.
  • Sevoflurane SPL • Structured Product Label • Official
    FDA Structured Product Label from the electronic animal drug product listing directory.
  • FlurovessTM SPL • Structured Product Label • Official
    FDA Structured Product Label from the electronic animal drug product listing directory.
  • FOI Summary oA 200-830 Approved January 30, 2026.pdf • FOI summary • Official • Feb. 2, 2026
    FDA FOI summary for application 200830
  • ucm061373.pdf • FOI summary • Official • March 14, 2024
    FDA FOI summary for application 200438
  • UCM202417.pdf • FOI summary • Official • Oct. 14, 2022
    FDA FOI summary for application 200467
  • ucm117135.pdf • FOI summary • Official • June 1, 2016
    FDA FOI summary for application 141103

Data Sources & Change Log

Every non-trivial field is expected to include provenance and update timestamps.

Official 130 Clinical 1 Manufacturer 0 Marketing 0
Current Field Facts
  • side_effects: Top reported reactions (openFDA): Vomiting, Death, Lethargy (see also Central nervous system depression in 'Neurological'), Bradycardia, Diarrhoea, Lack of eff… (Clinical, 2026-04-11)
  • contraindications: Federal law restricts this drug to use by or on the order of a licensed veterinarian. When using sevoflurane, patients should be continuously monitored and fac… (Official, 2026-04-12)
  • contraindications: Federal law restricts this drug to use by or on the order of a licensed veterinarian. When using sevoflurane, patients should be continuously monitored and fac… (Official, 2026-04-11)
  • contraindications: Federal law restricts this drug to use by or on the order of a licensed veterinarian. When using sevoflurane, patients should be continuously monitored and fac… (Official, 2026-02-12)
  • indications: PETREM is indicated for induction and maintenance of general anesthesia in dogs. (Official, 2026-08-06)
  • indications: PETREM is indicated for induction and maintenance of general anesthesia in dogs. (Official, 2026-08-05)
  • indications: PETREM is indicated for induction and maintenance of general anesthesia in dogs. (Official, 2026-08-04)
  • indications: PETREM is indicated for induction and maintenance of general anesthesia in dogs. (Official, 2026-08-03)
  • indications: PETREM is indicated for induction and maintenance of general anesthesia in dogs. (Official, 2026-08-02)
  • indications: PETREM is indicated for induction and maintenance of general anesthesia in dogs. (Official, 2026-08-01)
  • indications: PETREM is indicated for induction and maintenance of general anesthesia in dogs. (Official, 2026-07-31)
  • indications: PETREM is indicated for induction and maintenance of general anesthesia in dogs. (Official, 2026-07-30)
  • indications: PETREM is indicated for induction and maintenance of general anesthesia in dogs. (Official, 2026-07-29)
  • indications: PETREM is indicated for induction and maintenance of general anesthesia in dogs. (Official, 2026-07-28)
  • indications: PETREM is indicated for induction and maintenance of general anesthesia in dogs. (Official, 2026-07-27)
  • indications: PETREM is indicated for induction and maintenance of general anesthesia in dogs. (Official, 2026-07-26)
  • indications: PETREM is indicated for induction and maintenance of general anesthesia in dogs. (Official, 2026-07-25)
  • indications: PETREM is indicated for induction and maintenance of general anesthesia in dogs. (Official, 2026-07-25)
  • indications: PETREM is indicated for induction and maintenance of general anesthesia in dogs. (Official, 2026-07-22)
  • indications: PETREM is indicated for induction and maintenance of general anesthesia in dogs. (Official, 2026-07-22)
Recent Revisions
  • side_effects updated 2026-04-12 10:05 by etl_backfill • Backfilled from existing medication fields
  • contraindications updated 2026-04-12 10:05 by etl_backfill • Backfilled from existing medication fields
  • usage updated 2026-04-12 10:05 by etl_backfill • Backfilled from existing medication fields
  • side_effects updated 2026-04-11 10:05 by etl_backfill • Backfilled from existing medication fields
  • contraindications updated 2026-04-11 10:05 by etl_backfill • Backfilled from existing medication fields
  • usage updated 2026-04-11 10:05 by etl_backfill • Backfilled from existing medication fields
  • side_effects updated 2026-02-12 22:44 by etl_backfill • Backfilled from existing medication fields
  • contraindications updated 2026-02-12 22:44 by etl_backfill • Backfilled from existing medication fields
  • usage updated 2026-02-12 22:44 by etl_backfill • Backfilled from existing medication fields

FDA Products & Applications (Animal Drugs @ FDA)

Official sponsor/proprietary-name/application-status records linked by active ingredient.

Product Sponsor Application Status Published
Sevoflurane
RX
Sevoflurane
Liquid • Inhalation
Label highlights
Official documents
Parnell Technologies Pty. Ltd. ANADA 200-830 Approved Feb 2, 2026
Petrem®
RX
Sevoflurane
Liquid (Solution) • Inhalation
Label highlights
Official documents
Piramal Pharma Ltd. ANADA 200-438 Approved Mar 14, 2024
Sevospire™
RX
Sevoflurane
Liquid • Inhalation
Label highlights
Official documents
Dechra Veterinary Products LLC ANADA 200-467 Approved Oct 14, 2022
SevoFlo®
RX
Sevoflurane
Liquid • Inhalation
Label highlights
Official documents
Zoetis Inc. NADA 141-103 Approved Jun 1, 2016

Data source: FDA Animal Drugs @ FDA (public search export).

What It's For (FDA Label Highlights)

Extracted from FDA Animal Drugs @ FDA product labeling. Always confirm details with your veterinarian.

Composition / specifications
250 mL sevoflurane
Dogs
Indication

For induction and maintenance of general anesthesia in dogs.

Dosage

For induction of surgical anesthesia: up to 7 percent sevoflurane. For maintenance of surgical anesthesia: 3.7 to 4percent sevoflurane with oxygen in the absence of premedication and 3.3 to 3.6 percent in the presence of premedication.

Limitations

FDA page: Open in Animal Drugs @ FDA

Species: Dog
Label highlights
Indication
For induction and maintenance of general anesthesia in dogs.
Dosage
For induction of surgical anesthesia: Up to 7 percent sevoflurane with oxygen. For maintenance of surgical anesthesia: 3.7 to 4 percent sevoflurane with oxygen in the absence of premedication and 3.3 to 3.6 percent in the presence of premedication
Limitations
Federal law restricts this drug to use by or on the order of a licensed veterinarian.

FDA page: Open in Animal Drugs @ FDA

Species: Dog
Composition / specifications
250 mL sevoflurane
Dogs
Indication
For induction and maintenance of general anesthesia in dogs.
Dosage
Induction: For mask induction using Sevoflurane alone, inspired concentrations of up to 7% sevoflurane with oxygen are employed to induce surgical anesthesia in the healthy dog. Maintenance: Surgical levels of anesthesia in the healthy dog may be maintained with inhaled concentrations of 3.7-4.0% sevoflurane in oxygen in the absence of premedication and 3.3-3.6% in the presence of premedication.
Limitations
Federal law restricts this drug to use by or on the order of a licensed veterinarian.

FDA page: Open in Animal Drugs @ FDA

Species: Dog
Dogs
Indication
SevoFlo is indicated for induction and maintenance of general anesthesia in dogs.
Dosage
For induction of surgical anesthesia: Up to 7 percent sevoflurane with oxygen. For maintenance of surgical anesthesia: 3.7 to 4 percent sevoflurane with oxygen in the absence of premedication and 3.3 to 3.6 percent in the presence of premedication.
Limitations
Federal law restricts this drug to use by or on the order of a licensed veterinarian. When using sevoflurane, patients should be continuously monitored and facilities for maintenance of patent airway, artificial ventilation, and oxygen supplementation must be immediately available

FDA page: Open in Animal Drugs @ FDA

Usage

SevoFlo is indicated for induction and maintenance of general anesthesia in dogs. For induction and maintenance of general anesthesia in dogs.

Source: FDA Animal Drugs @ FDA • Reference

Contraindications

Federal law restricts this drug to use by or on the order of a licensed veterinarian. When using sevoflurane, patients should be continuously monitored and facilities for maintenance of patent airway, artificial ventilation, and oxygen supplementation must be immediately available Federal law restricts this drug to use by or on the order of a licensed veterinarian.

Top Reported Reactions (openFDA)

De-duplicated reaction terms grouped by body system from FDA openFDA reports (not verified; does not prove causation).

Digestive
Loss of appetite (1) • Dog Appetite loss (1) • Dog

Showing top 5 for Digestive.

Skin & allergy
Hair loss at application site (1) • Cat Application site hair loss (1) • Cat Alopecia general (1) • Dog

Showing top 5 for Skin & allergy.

Neurologic
Unsteady walking (1) • Cat

Showing top 5 for Neurologic.

Behavior
Anxiety (1) • Dog

Showing top 5 for Behavior.

Other
Arthritis (1) • Dog Application site ulcer (1) • Cat Application site scratching (1) • Cat Application site scab (1) • Cat Application site reddening (1) • Cat
Show more (20)
Application site pustule (1) • Dog Application site lesion (1) • Cat Application site discharge NOS (1) • Cat Application site bleeding (1) • Cat Anaphylaxis (1) • Cat Anaemia NOS (1) • Dog Allergy NOS (1) • Dog Allergic oedema (1) • Dog Adipsia (1) • Cat Acute renal failure (1) • Dog Acid-base disorder (1) • Dog Abnormal ultrasound finding (1) • Dog Abnormal radiograph finding (1) • Dog Abnormal electrocardiogram (1) • Dog Abnormal cytology (1) • Dog Abnormal breathing (1) • Dog Abdominal pain (1) • Dog Abdominal exudate (1) • Dog Abdominal effusion (1) • Dog Abdominal discomfort (1) • Dog

Showing top 5 for Other.

Data source: FDA openFDA Animal & Veterinary adverse event reports.

Adverse Event Case Summaries (openFDA)

These are individual FDA adverse event reports. They are unverified and do not prove the medication caused the reaction.

Cat, Siamese, Male, 1 year, 4.763 kilogram • Drug: MSK, Solution, Unknown, Dose: 1 Unknown per unknown • Reactions: Anaphylaxis, Vomiting, Bloody stool, Tiredness (lethargy), Hypothermia… • Outcome: Ongoing

  • Report ID: USA-USFDACVM-2026-US-013383
  • Serious AE: Yes
  • Treated For AE: No
  • Sex: Male
  • Age: 1.00 Year
  • Weight: 4.763 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Unknown
  • Form: Solution
  • Dose: 1 Unknown per unknown
Reactions Reported:
Anaphylaxis Vomiting Bloody stool Tiredness (lethargy) Hypothermia Elevated alanine aminotransferase Elevated blood urea nitrogen Hyperphosphataemia Leukocytosis NOS Elevated total bilirubin
Outcomes: Ongoing

Cat, ['Siberian', 'Crossbred Feline/cat'], Female, 4.83 year, 4.85 kilogram • Drug: MSK, Parenteral • Reactions: Application site discharge NOS, Application site reddening, Application site hair loss, Application site lesion • Outcome: Ongoing

  • Report ID: USA-USFDACVM-2026-US-012565
  • Serious AE: No
  • Treated For AE: Yes
  • Sex: Female
  • Age: 4.83 Year
  • Weight: 4.850 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Parenteral
Reactions Reported:
Application site discharge NOS Application site reddening Application site hair loss Application site lesion
Outcomes: Ongoing

Cat, Domestic Shorthair, Male, 4.9 year, 5.5 kilogram • Drug: MSK • Reactions: Unsteady walking (ataxia), Vestibular disorder NOS, Hyperglycaemia, Breathing difficulty, Other blood disorder NOS… • Outcome: Ongoing

  • Report ID: USA-USFDACVM-2026-US-013310
  • Serious AE: Yes
  • Treated For AE: No
  • Sex: Male
  • Age: 4.90 Year
  • Weight: 5.500 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
Reactions Reported:
Unsteady walking (ataxia) Vestibular disorder NOS Hyperglycaemia Breathing difficulty Other blood disorder NOS Loss of appetite Walking difficulty Low platelet count Horizontal nystagmus Hypokalaemia Decreased blood urea nitrogen (BUN) or creatinine Falling Behavioral disorder (unspecified) Head tilt - neurological disorder Adipsia Drooling Difficulty chewing Ocular discharge Hyperalbuminaemia Twitching Vocalisation Eosinophilia Hypochloraemia Incoordination Dehydration Hyperproteinaemia Decreased activity Urinary bladder disorder NOS Frequent micturition Diarrhea
Outcomes: Ongoing

Cat, Siamese, Male, 1 year, 4.763 kilogram • Drug: MSK, Unassigned, Unknown • Reactions: Anaphylaxis, Vomiting, Bloody stool, Tiredness (lethargy), Hypothermia… • Outcome: Ongoing

  • Report ID: USA-USFDACVM-2026-US-008820
  • Serious AE: Yes
  • Treated For AE: No
  • Sex: Male
  • Age: 1.00 Year
  • Weight: 4.763 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Unknown
  • Form: Unassigned
Reactions Reported:
Anaphylaxis Vomiting Bloody stool Tiredness (lethargy) Hypothermia Elevated alanine aminotransferase Elevated blood urea nitrogen Hyperphosphataemia Leukocytosis NOS Elevated total bilirubin
Outcomes: Ongoing

Dog, Bulldog - English, Female, 10 year, 20.1 kilogram • Drug: MSK, Solution, Respiratory (Inhalation) • Reactions: Trouble breathing (dyspnea), Pale mucous membrane, Elevated C-reactive protein, Tiredness (lethargy), Vomiting… • Outcome: Euthanized

  • Report ID: NOR-USFDACVM-2026-NO-000003
  • Serious AE: Yes
  • Treated For AE: Yes
  • Sex: Female
  • Age: 10.00 Year
  • Weight: 20.100 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Respiratory (Inhalation)
  • Form: Solution
Reactions Reported:
Trouble breathing (dyspnea) Pale mucous membrane Elevated C-reactive protein Tiredness (lethargy) Vomiting Anaemia NOS Leukocytosis NOS Loss of appetite Regurgitation Weakness Prolonged capillary refill time Tachycardia Weak pulse Abnormal breathing Hypovolaemic shock Abnormal ultrasound finding Gastric ulcer Peritonitis Abdominal effusion Impaired gastric function Death by euthanasia
Outcomes: Euthanized

Dog, Retriever - Labrador, Female, 9 year, 29.8 kilogram • Drug: MSK, Solution, Respiratory (Inhalation) • Reactions: Restlessness, Vocalisation, Pain NOS, Dull, Subdued… • Outcome: Euthanized

  • Report ID: NOR-USFDACVM-2026-NO-000002
  • Serious AE: Yes
  • Treated For AE: Yes
  • Sex: Female
  • Age: 9.00 Year
  • Weight: 29.800 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Respiratory (Inhalation)
  • Form: Solution
Reactions Reported:
Restlessness Vocalisation Pain NOS Dull Subdued Uncomfortable Melaena Abdominal pain Loss of appetite Decreased red blood cell count Decreased haematocrit Decreased haemoglobin Decreased mean corpuscular volume Decreased percentage of reticulocytes Thrombocytopenia Hypoproteinaemia Abnormal ultrasound finding Abdominal effusion Fever Tachycardia Hyperaemic mucous membrane Abdominal exudate Peritoneal fluid, high white blood cell count Gastric ulcer Low thyroxine Low free thyroxine Death by euthanasia
Outcomes: Euthanized

Dog, Dog (other), Male, 9 year, 24 kilogram • Drug: MSK, Solution, Respiratory (Inhalation) • Reactions: Hypernatraemia, Hyperkalaemia, Low thyroxine, Low free thyroxine, Diarrhea… • Outcome: Recovered/Normal

  • Report ID: NOR-USFDACVM-2026-NO-000001
  • Serious AE: Yes
  • Treated For AE: Yes
  • Sex: Male
  • Age: 9.00 Year
  • Weight: 24.000 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Respiratory (Inhalation)
  • Form: Solution
Reactions Reported:
Hypernatraemia Hyperkalaemia Low thyroxine Low free thyroxine Diarrhea Vomiting Not himself/herself Loss of appetite Tiredness (lethargy) Panting Weight loss Tachycardia Weak pulse Fever Abdominal discomfort Elevated C-reactive protein Anaemia NOS Decreased haematocrit Decreased haemoglobin Decreased mean corpuscular haemoglobin concentration Decreased red cell distribution width Other abnormal test result NOS Neutrophilia Monocytosis Hypoalbuminaemia Abnormal ultrasound finding Gastric ulcer Peritonitis Blood in faeces Melaena Bloody diarrhoea
Outcomes: Recovered/Normal

Cat, Domestic Shorthair, Male, 6.42 year, 6.894 kilogram • Drug: MSK, Unknown • Reactions: Open mouth breathing, Respiratory distress, Fever, Not eating • Outcome: Recovered/Normal

  • Report ID: USA-USFDACVM-2026-US-009550
  • Serious AE: Yes
  • Treated For AE: Yes
  • Sex: Male
  • Age: 6.42 Year
  • Weight: 6.894 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Unknown
Reactions Reported:
Open mouth breathing Respiratory distress Fever Not eating
Outcomes: Recovered/Normal

Data source: FDA openFDA Animal & Veterinary adverse event reports.

Overdose Information

No approved overdose-management text is linked yet. If overdose is suspected, contact a veterinarian or emergency clinic immediately.

Storage & Handling

No approved storage guidance is linked yet for this ingredient. Use manufacturer packaging and veterinary guidance for handling/storage.

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