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Roxee Medication Guide

Sevoflurane

Medication reference facts with explicit FDA-approval, off-label, source-limited, and safety context. Roxee does not sell, prescribe, or dispense medications.

Both Reference complete FDA data linked Rx required Liquid Multiple FDA labelers Official label facts Owner quick guide first
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Data freshness

Reference facts
Reference refreshed
Jun 22, 2026, 10:41 a.m.

These are the reference facts Roxee uses on browse cards and quick facts.

FDA applications
FDA application data refreshed
Jun 22, 2026, 10:41 a.m.

Sponsor, product, and application records imported from Animal Drugs @ FDA.

Safety reports
Safety data refreshed
Jun 13, 2026, 11:29 a.m.

openFDA reaction terms and case summaries are supporting evidence, not proof of causality.

Source timing details
Source timing details
  • Reference facts: Source Roxee | Refreshed Jun 22, 2026, 10:41 AM UTC
    The reference fact projection used for browse cards and quick facts.
  • Animal Drugs @ FDA: Source FDA | Refreshed Jun 22, 2026, 10:41 AM UTC
    Applications/products are imported from FDA export data.
  • Animal Drugs @ FDA previews: Source FDA | Refreshed Feb 9, 2026, 3:05 AM UTC
    Label highlights/doc links are fetched from FDA preview endpoints.
  • Animal Drug Product Listing Directory (NDC): Source FDA | Refreshed Jun 22, 2026, 10:41 AM UTC
    Package/product NDCs from FDA’s electronic listing directory (XLS).
  • openFDA reaction terms: Source FDA openFDA | Refreshed Jun 22, 2026, 10:45 AM UTC
  • openFDA case summaries: Source FDA openFDA | Refreshed Jun 22, 2026, 10:45 AM UTC
Image coming soon
Sevoflurane

Sevoflurane

Drug type: Generic ingredient • Branded profile • FDA branded products available

Both Liquid Rx required 100% reference complete

Species: Both

Manufacturer: Multiple FDA labelers

Medication Snapshot

Merged from the current Roxee medication system with field-level provenance, freshness, and completeness tracking.

Sevoflurane

SevoFlo is indicated for induction and maintenance of general anesthesia in dogs. For induction and maintenance of general anesthesia in dogs. Species commonly shown: Both, Dog.

Generic name
Sevoflurane
Brand names
SevoFlo®, Petrem®, Sevospire™, Sevoflurane
Manufacturer
Multiple FDA labelers
Species
Both, Dog
Dosage forms
Liquid, Liquid (Solution)
Prescription
Prescription required
Completeness
100%
Validation
Complete
Brand names
SevoFlo® Petrem® Sevospire™ Sevoflurane SevoFlo Sevospire FlurovessTM Petrem
Dosage forms
Liquid Liquid (Solution)

Indications / Uses

SevoFlo is indicated for induction and maintenance of general anesthesia in dogs. For induction and maintenance of general anesthesia in dogs.

Warnings / Contraindications

Federal law restricts this drug to use by or on the order of a licensed veterinarian. When using sevoflurane, patients should be continuously monitored and facilities for maintenance of patent airway, artificial ventilation, and oxygen supplementation must be immediately available Federal law restricts this drug to use by or on the order of a licensed veterinarian.

  • Federal law restricts this drug to use by or on the order of a licensed veterinarian. When using sevoflurane, patients should be continuously monitored and facilities for maintenance of patent airway, artificial ventilation, and oxygen supplementation must be immediately available Federal law restricts this drug to use by or on the order of a licensed veterinarian.

Side Effects

Top reported reactions (openFDA): Vomiting, Death, Lethargy (see also Central nervous system depression in 'Neurological'), Bradycardia, Diarrhoea, Lack of efficacy - NOS.

FAQ

Both, Dog

Yes. Roxee shows this as prescription-only.

Liquid, Liquid (Solution)

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Pet Owner Quick Guide

Start here first for the safest next-step summary before the deeper medication detail.

Used for:

For induction and maintenance of general anesthesia in dogs.

Dosing note:

Exact dosing depends on your pet's species, weight, and health status. Use your veterinarian's instructions for the exact dose and schedule.

What to watch for:

  • trouble breathing (1 reports)
  • Loss of appetite (1 reports)
  • Focal seizure (1 reports)

When to call the vet:

  • Repeated vomiting or diarrhea.
  • Severe lethargy (hard to wake, very low energy).
  • Collapse or fainting.
  • Facial swelling or hives.
  • Blood in vomit or stool.

Regulatory restrictions are shown in Vet View.

What to tell or ask your vet today:

  • Is this medicine the right fit for my pet’s current symptoms?
  • Which warning signs mean I should call back right away?
  • How should I handle missed doses or refusal to take the medicine?

Next actions

Talk to a Vet / Find a Vet Near You Save to pet meds Share page Review report evidence
Research brief

Medication Research Insights

A source-aware map of what to know, what is uncertain, and what to verify with your veterinarian.

Source Backed Signals

What to know

Evidence-backed context Limited

Roxee has limited cited overview evidence for Sevoflurane; use the official documents and your veterinarian's instructions for product-specific decisions.

Source: openFDA case USA-USFDACVM-2025-US-054707
Safety signal coverage Reported signals

32 tracked reaction signals; 32 reported cases; 19 serious reports; 2 species groups. These are reporting and label-derived signals for interpretation with a veterinarian.

Source: openFDA case USA-USFDACVM-2025-US-054707
Interpretation guardrail Not causation

Adverse-event reports help form a watch list, but they do not prove the medication caused the reaction and they are not a risk ranking between medications.

Evidence tension

Stronger signal Label / review

Official labels, package inserts, and reviewed summaries carry more weight than isolated reports.

Source: openFDA case USA-USFDACVM-2025-US-054707
Weaker signal Reported data

Case reports and openFDA terms are useful for pattern awareness, but they are incomplete, can include multiple exposures, and do not estimate an individual pet's probability of harm.

Reaction signal map

Most reported reactions Top terms

Trouble breathing (dyspnea) (1 reports), Loss of appetite (1 reports), Focal seizure (1 reports), Excessive chewing, licking and/or grooming (1 reports), Elevated serum alkaline phosphatase (1 reports)

Body systems represented Signal grouping

Digestive (4), Skin & allergy (1), Neurologic (2), Other (25)

Explore supporting adverse reports

Species and breed lens

Species represented in reports Species lens

Dog (20 reports), Cat (12 reports)

Breed metadata in reports Metadata only

Bulldog - French (1), Maine Coon (1), ['Sheepdog - Beauce (Beauceron)', 'Poodle (unspecified)'] (1), Domestic Shorthair (1). These are report metadata, not proof that a breed is at higher risk.

What your vet may verify

Fit for this patient Vet check

Verify whether Sevoflurane fits the pet's species, current diagnosis, age, weight, organ status, pregnancy/lactation status, and concurrent medications.

Evidence limitations Evidence review

Separate label-backed warnings from adverse-event reports and owner observations before changing the plan.

What to watch next

Watch list Owner-safe

trouble breathing, Loss of appetite, Focal seizure

Call sooner if Escalation

Repeated vomiting or diarrhea. Severe lethargy (hard to wake, very low energy). Collapse or fainting.

Bottom line: Use this Sevoflurane brief as a structured watch list and source map, not as a reason to start, stop, or change treatment without your veterinarian.
Vet source depth
  1. openFDA case USA-USFDACVM-2025-US-054707 · adverse_reaction · adverse reactions
  2. Contraindication source · fda_animal_drugs · warnings contraindications
  3. FDA application profile · official_label · quick facts
  4. FDA application profile · official_label · quick facts
  5. Medication usage source · fda_animal_drugs · quick facts
  6. FOI · document · documents
  7. SPL · document · documents
  8. FOI · document · documents

Evidence

Review status / Updated / Sources

Review status: Clinical reviewer not listed

Updated: February 12, 2026, 10:44 PM UTC

Sources:
Safety & side effects

Side effects to monitor:

  • trouble breathing
  • Loss of appetite
  • Focal seizure

Most reported reactions:

  • Trouble breathing (dyspnea) (1 reports)
  • Loss of appetite (1 reports)
  • Focal seizure (1 reports)
Explore reported case details

Emergency warning signs:

  • Repeated vomiting or diarrhea.
  • Severe lethargy (hard to wake, very low energy).
  • Collapse or fainting.
  • Facial swelling or hives.
Talk to a Vet / Find a Vet Near You Start Symptom Intake

Vet Fast Scan

Source-backed clinical checkpoints for quick review.

FDA-labeled species
Dog
Indication / use
For induction and maintenance of general anesthesia in dogs.
Form / route / dose
Form: Liquid, Liquid (Solution)
Route: Inhalation
Confirm product label and patient-specific plan.
Warnings
  • High: Federal law restricts this drug to use by or on the order of a licensed veterinarian. When using sevoflurane, patients …
Adverse-event caveat
openFDA adverse-event cases are reported signals. They are not verified, do not prove causation, and do not estimate a pet's individual risk.
Source docs

Quick Facts

Official label facts first, then secondary summaries. Marketing content is separated below.

Species: Both
Manufacturer: Multiple FDA labelers
Form: Liquid, Liquid (Solution)
Identifiers:
ANADA: 200438 ANADA: 200467 ANADA: 200830 NADA: 141103 NDC Package: 11695-0505-2 NDC Package: 13985-711-25 NDC Package: 17033-092-25 NDC Package: 46066-116-04 NDC Package: 54771-5458-2 NDC Package: 66794-018-10 NDC Package: 66794-018-25 NDC Package: 68504-011-01 NDC Product: 11695 NDC Product: 13985 NDC Product: 17033 NDC Product: 46066 NDC Product: 54771 NDC Product: 66794 NDC Product: 68504
Source metadata:

Warnings / Contraindications

Federal law restricts this drug to use by or on the order of a licensed veterinarian. When using sevoflurane, patients should be continuously monitored and facilities for maintenance of patent airway, artificial ventilation, and oxygen supplementation must be immediately available Federal law restricts this drug to use by or on the order of a licensed veterinarian.

  • High: Federal law restricts this drug to use by or on the order of a licensed veterinarian. When using sevoflurane, patients should be continuously monitored and facilities for maintenance of patent airway, artificial ventilation, and oxygen supplementation must be immediately available Federal law restricts this drug to use by or on the order of a licensed veterinarian.
Source metadata:

Adverse Reactions

Snapshot first, detailed rows second. This section summarizes signal data and is not a diagnosis.

Reported case explorer

Filter stored openFDA reports by pet and report attributes. Counts describe reports in this data set, not risk.

Clear filters
openFDA adverse-event cases are reported signals. They are not verified, do not prove causation, and do not estimate a pet's individual risk.
Stored reports
6
Matching reports
1
Active filters
2
Selected filters
Reaction: Acute renal failure Clear Body system: Digestive Clear
Reset
Drill into common report signals
Lethargy (see also Central nervous system depression in Neurological) (2) Abnormal radiograph finding (1) Acute renal failure (1) Appetite loss (1) Other (6) Neurologic (3) Digestive (2) Skin & allergy (2)
Showing up to 50 matching reports.

DNK-USFDACVM-2025-DK-000007

Received 2025-12-01 · MSK · MSK

Serious
Species
Dog
Breed
Terrier - Bull - Staffordshire
Size / weight
25-49 lb (16.5 Kilogram)
Age
1-3 years (14 Month)
Sex
Male Neutered
Region
USA
Reactions
DepressionAppetite lossApplication site pustuleDehydrationAcute renal failurePolyuriaPolydipsia
Body systems
NeurologicDigestiveOther
Outcomes
Recovered/Normal

Tap or hover a reaction to see what it means in plain language.

Tracked signals
32
Reported cases
32
Serious reports
19
Species represented
2
Grouped by Body System
Digestive (4) · Loss of appetite, Diarrhea, Decreased appetite Skin & allergy (1) · Hair loss at application site Neurologic (2) · Focal seizure, Depression Other (25) · Trouble breathing (dyspnea), Fear/fearful, Excessive chewing, licking and/or grooming
Most Reported Reactions
Reaction Body system Cases Species Serious cases
Other 1 Dog 1
Digestive 1 Dog 1
Neurologic 1 Cat 1
Other 1 Dog 1
Other 1 Dog 1
Neurologic 1 Dog 1
Other 1 Dog 1
Other 1 Dog 1

Species coverage: Dog (20) Cat (12)

View detailed reaction table
Reaction Body system Species Seriousness Frequency Reports
Other Dog Serious - 1
Digestive Dog Serious - 1
Skin & allergy Cat Non-serious - 1
Neurologic Cat Serious - 1
Other Cat Non-serious - 1
Other Dog Serious - 1
Other Dog Serious - 1
Other Cat Non-serious - 1
Other Cat Non-serious - 1
Digestive Cat Non-serious - 1
Neurologic Dog Serious - 1
Other Dog Serious - 1
Other Cat Non-serious - 1
Other Dog Serious - 1
Digestive Dog Serious - 1
Other Dog Serious - 1
Other Dog Serious - 1
Other Dog Serious - 1
Other Dog Serious - 1
Other Cat Non-serious - 1
Other Cat Non-serious - 1
Other Cat Non-serious - 1
Other Dog Serious - 1
Other Cat Non-serious - 1
Other Cat Non-serious - 1
Digestive Dog Serious - 1
Other Dog Non-serious - 1
Other Dog Serious - 1
Other Dog Serious - 1
Other Dog Serious - 1
Other Dog Non-serious - 1
Other Dog Serious - 1
Source metadata:

Source Documents

The most useful source links appear first; full previews and metadata stay in the veterinary/professional layer.

Use original documents to confirm product-specific warnings, ingredients, and handling details with your veterinarian.

Sevoflurane SPL · SPL Petrem® SPL · SPL Sevospire™ SPL · SPL

Full source previews and metadata remain in the veterinary/professional layer.

Owner handouts

0
No owner handouts linked yet.

Official label / PI

0
No official label or package insert links yet.

SPL

11

FOI

4

Sevoflurane

SPL · SPL

Open original
FDA Structured Product Label

Sevoflurane

Rendered from Roxee's cached FDA SPL package contents for on-page reading. Use Open original for the raw FDA ZIP/XML source.

Sponsor
Parnell Technologies Pty. Ltd.
ANADA
200-830
Status
RX
Form
Liquid
Route
Inhalation
Composition / specifications
250 mL sevoflurane

Dogs

Indication

For induction and maintenance of general anesthesia in dogs.

Dosage

For induction of surgical anesthesia: up to 7 percent sevoflurane. For maintenance of surgical anesthesia: 3.7 to 4percent sevoflurane with oxygen in the absence of premedication and 3.3 to 3.6 percent in the presence of premedication.

Petrem®

SPL · SPL

Open original
FDA Structured Product Label

Petrem®

Rendered from Roxee's cached FDA SPL package contents for on-page reading. Use Open original for the raw FDA ZIP/XML source.

Sponsor
Piramal Pharma Ltd.
ANADA
200-438
Status
RX
Form
Liquid (Solution)
Route
Inhalation
Species
Dog

Label highlights

Indication
For induction and maintenance of general anesthesia in dogs.
Dosage
For induction of surgical anesthesia: Up to 7 percent sevoflurane with oxygen. For maintenance of surgical anesthesia: 3.7 to 4 percent sevoflurane with oxygen in the absence of premedication and 3.3 to 3.6 percent in the presence of premedication
Limitations
Federal law restricts this drug to use by or on the order of a licensed veterinarian.

Sevospire™

SPL · SPL

Open original
FDA Structured Product Label

Sevospire™

Rendered from Roxee's cached FDA SPL package contents for on-page reading. Use Open original for the raw FDA ZIP/XML source.

Sponsor
Dechra Veterinary Products LLC
ANADA
200-467
Status
RX
Form
Liquid
Route
Inhalation
Species
Dog
Composition / specifications
250 mL sevoflurane

Dogs

Indication
For induction and maintenance of general anesthesia in dogs.
Dosage
Induction: For mask induction using Sevoflurane alone, inspired concentrations of up to 7% sevoflurane with oxygen are employed to induce surgical anesthesia in the healthy dog. Maintenance: Surgical levels of anesthesia in the healthy dog may be maintained with inhaled concentrations of 3.7-4.0% sevoflurane in oxygen in the absence of premedication and 3.3-3.6% in the presence of premedication.
Limitations
Federal law restricts this drug to use by or on the order of a licensed veterinarian.

SevoFlo®

SPL · SPL

Open original
FDA Structured Product Label

SevoFlo®

Rendered from Roxee's cached FDA SPL package contents for on-page reading. Use Open original for the raw FDA ZIP/XML source.

Sponsor
Zoetis Inc.
NADA
141-103
Status
RX
Form
Liquid
Route
Inhalation
Species
Dog

Dogs

Indication
SevoFlo is indicated for induction and maintenance of general anesthesia in dogs.
Dosage
For induction of surgical anesthesia: Up to 7 percent sevoflurane with oxygen. For maintenance of surgical anesthesia: 3.7 to 4 percent sevoflurane with oxygen in the absence of premedication and 3.3 to 3.6 percent in the presence of premedication.
Limitations
Federal law restricts this drug to use by or on the order of a licensed veterinarian. When using sevoflurane, patients should be continuously monitored and facilities for maintenance of patent airway, artificial ventilation, and oxygen supplementation must be immediately available

Sevospire SPL

SPL · Structured Product Label

Open original
FDA Structured Product Label XML for Sevospire. Use the source link for the full official labeling record.

SevoFlo SPL

SPL · Structured Product Label

Open original
FDA Structured Product Label XML for SevoFlo. Use the source link for the full official labeling record.

Sevoflurane SPL

SPL · Structured Product Label

Open original
FDA Structured Product Label XML for Sevoflurane. Use the source link for the full official labeling record.

Sevoflurane SPL

SPL · Structured Product Label

Open original
FDA Structured Product Label XML for Sevoflurane. Use the source link for the full official labeling record.

Petrem SPL

SPL · Structured Product Label

Open original
FDA Structured Product Label XML for Petrem. Use the source link for the full official labeling record.

Sevoflurane SPL

SPL · Structured Product Label

Open original
FDA Structured Product Label XML for Sevoflurane. Use the source link for the full official labeling record.

FlurovessTM SPL

SPL · Structured Product Label

Open original
FDA Structured Product Label XML for FlurovessTM. Use the source link for the full official labeling record.

FOI Summary oA 200-830 Approved January 30, 2026.pdf

FOI · FOI

Open original

ucm061373.pdf

FOI · FOI

Open original

UCM202417.pdf

FOI · FOI

Open original

ucm117135.pdf

FOI · FOI

Open original
Source metadata:
Veterinary reference (advanced)

Canonical medication sections are above. This legacy block remains available for deeper cross-reference without cluttering the primary workflow.

At a Glance

Quick facts and links to official labeling and safety signals.

Data freshness
  • Reference facts: Source Roxee | Refreshed Jun 22, 2026, 10:41 AM UTC
    The reference fact projection used for browse cards and quick facts.
  • Animal Drugs @ FDA: Source FDA | Refreshed Jun 22, 2026, 10:41 AM UTC
    Applications/products are imported from FDA export data.
  • Animal Drugs @ FDA previews: Source FDA | Refreshed Feb 9, 2026, 3:05 AM UTC
    Label highlights/doc links are fetched from FDA preview endpoints.
  • Animal Drug Product Listing Directory (NDC): Source FDA | Refreshed Jun 22, 2026, 10:41 AM UTC
    Package/product NDCs from FDA’s electronic listing directory (XLS).
  • openFDA reaction terms: Source FDA openFDA | Refreshed Jun 22, 2026, 10:45 AM UTC
  • openFDA case summaries: Source FDA openFDA | Refreshed Jun 22, 2026, 10:45 AM UTC
Official (FDA)
Identity: Generic ingredient • FDA branded products available
Official FDA brands: FlurovessTM Petrem SevoFlo Sevoflurane Sevospire
Manufacturer mapping: Multiple FDA labelers
Case-reported brands (openFDA): MSK
Catalog species: Both • FDA-labeled species: Dog
Rx/OTC: RX
Form/route: Liquid, Liquid (Solution) • Inhalation
Applications: ANADA 200-830 • ANADA 200-438 • ANADA 200-467 • NADA 141-103
NDC: Packages 11695-0505-2 13985-711-25 17033-092-25 46066-116-04 54771-5458-2 66794-018-10 • Products 11695 13985 17033 46066 54771 66794
Documents: 4 (FOI: 4) • SPL: 4 • Label highlights • Official documents
Safety (openFDA)
Top reactions: Dog 27 • Cat 7 • View
Case summaries: 6 (showing 6) • View
openFDA reports are unverified and do not prove causation.
Diagnosis Codes

Diagnosis-code mappings are not available for this medication yet.

Counseling and Monitoring Highlights

Global Pet owner/Vet mode is controlled in the header. This section avoids duplicate in-page persona tabs.

Owner-facing counseling points
  • Federal law restricts this drug to use by or on the order of a licensed veterinarian. When using sevoflurane, patients should be continuously monitored and facilities for maintenance of patent airway, artificial ventilation, and oxygen supplementation must be immediately available Federal law restricts this drug to use by or on the order of a licensed veterinarian. (Contraindication, High)
Top reaction signals
Trouble breathing (dyspnea) (1) Loss of appetite (1) Focal seizure (1) Excessive chewing, licking and/or grooming (1) Elevated serum alkaline phosphatase (1) Depression (1) Dehydration (1) Decreased drinking (1)

Identifiers & Packages

Normalized identifiers (NDC/NADA/ANADA) and package metadata from regulator listings.

Identifiers
ANADA: 200438 ANADA: 200467 ANADA: 200830 NADA: 141103 NDC Package: 11695-0505-2 NDC Package: 13985-711-25 NDC Package: 17033-092-25 NDC Package: 46066-116-04 NDC Package: 54771-5458-2 NDC Package: 66794-018-10 NDC Package: 66794-018-25 NDC Package: 68504-011-01 NDC Product: 11695 NDC Product: 13985 NDC Product: 17033 NDC Product: 46066 NDC Product: 54771 NDC Product: 66794 NDC Product: 68504
Package NDC Product NDC Form / Route Status
11695-0505-2 11695 -
13985-711-25 13985 -
17033-092-25 17033 -
46066-116-04 46066 -
54771-5458-2 54771 -
66794-018-10 66794 -
66794-018-25 66794 -
68504-011-01 68504 -

Enriched Documents

Documents are tiered by source trust: Official, Clinical, Manufacturer, Marketing.

  • Sevospire SPL • Structured Product Label • Official
    FDA Structured Product Label from the electronic animal drug product listing directory.
  • SevoFlo SPL • Structured Product Label • Official
    FDA Structured Product Label from the electronic animal drug product listing directory.
  • Sevoflurane SPL • Structured Product Label • Official
    FDA Structured Product Label from the electronic animal drug product listing directory.
  • Sevoflurane SPL • Structured Product Label • Official
    FDA Structured Product Label from the electronic animal drug product listing directory.
  • Petrem SPL • Structured Product Label • Official
    FDA Structured Product Label from the electronic animal drug product listing directory.
  • Sevoflurane SPL • Structured Product Label • Official
    FDA Structured Product Label from the electronic animal drug product listing directory.
  • FlurovessTM SPL • Structured Product Label • Official
    FDA Structured Product Label from the electronic animal drug product listing directory.
  • FOI Summary oA 200-830 Approved January 30, 2026.pdf • FOI summary • Official • Feb. 2, 2026
    FDA FOI summary for application 200830
  • ucm061373.pdf • FOI summary • Official • March 14, 2024
    FDA FOI summary for application 200438
  • UCM202417.pdf • FOI summary • Official • Oct. 14, 2022
    FDA FOI summary for application 200467
  • ucm117135.pdf • FOI summary • Official • June 1, 2016
    FDA FOI summary for application 141103

Data Sources & Change Log

Every non-trivial field is expected to include provenance and update timestamps.

Official 130 Clinical 1 Manufacturer 0 Marketing 0
Current Field Facts
  • side_effects: Top reported reactions (openFDA): Vomiting, Death, Lethargy (see also Central nervous system depression in 'Neurological'), Bradycardia, Diarrhoea, Lack of eff… (Clinical, 2026-04-11)
  • contraindications: Federal law restricts this drug to use by or on the order of a licensed veterinarian. When using sevoflurane, patients should be continuously monitored and fac… (Official, 2026-04-12)
  • contraindications: Federal law restricts this drug to use by or on the order of a licensed veterinarian. When using sevoflurane, patients should be continuously monitored and fac… (Official, 2026-04-11)
  • contraindications: Federal law restricts this drug to use by or on the order of a licensed veterinarian. When using sevoflurane, patients should be continuously monitored and fac… (Official, 2026-02-12)
  • indications: PETREM is indicated for induction and maintenance of general anesthesia in dogs. (Official, 2026-06-22)
  • indications: PETREM is indicated for induction and maintenance of general anesthesia in dogs. (Official, 2026-06-22)
  • indications: PETREM is indicated for induction and maintenance of general anesthesia in dogs. (Official, 2026-06-21)
  • indications: PETREM is indicated for induction and maintenance of general anesthesia in dogs. (Official, 2026-06-20)
  • indications: PETREM is indicated for induction and maintenance of general anesthesia in dogs. (Official, 2026-06-13)
  • indications: PETREM is indicated for induction and maintenance of general anesthesia in dogs. (Official, 2026-06-12)
  • indications: PETREM is indicated for induction and maintenance of general anesthesia in dogs. (Official, 2026-06-12)
  • indications: PETREM is indicated for induction and maintenance of general anesthesia in dogs. (Official, 2026-06-11)
  • indications: PETREM is indicated for induction and maintenance of general anesthesia in dogs. (Official, 2026-06-11)
  • indications: PETREM is indicated for induction and maintenance of general anesthesia in dogs. (Official, 2026-06-10)
  • indications: PETREM is indicated for induction and maintenance of general anesthesia in dogs. (Official, 2026-06-09)
  • indications: PETREM is indicated for induction and maintenance of general anesthesia in dogs. (Official, 2026-06-08)
  • indications: PETREM is indicated for induction and maintenance of general anesthesia in dogs. (Official, 2026-06-07)
  • indications: PETREM is indicated for induction and maintenance of general anesthesia in dogs. (Official, 2026-06-06)
  • indications: PETREM is indicated for induction and maintenance of general anesthesia in dogs. (Official, 2026-06-05)
  • indications: PETREM is indicated for induction and maintenance of general anesthesia in dogs. (Official, 2026-06-04)
Recent Revisions
  • side_effects updated 2026-04-12 10:05 by etl_backfill • Backfilled from existing medication fields
  • contraindications updated 2026-04-12 10:05 by etl_backfill • Backfilled from existing medication fields
  • usage updated 2026-04-12 10:05 by etl_backfill • Backfilled from existing medication fields
  • side_effects updated 2026-04-11 10:05 by etl_backfill • Backfilled from existing medication fields
  • contraindications updated 2026-04-11 10:05 by etl_backfill • Backfilled from existing medication fields
  • usage updated 2026-04-11 10:05 by etl_backfill • Backfilled from existing medication fields
  • side_effects updated 2026-02-12 22:44 by etl_backfill • Backfilled from existing medication fields
  • contraindications updated 2026-02-12 22:44 by etl_backfill • Backfilled from existing medication fields
  • usage updated 2026-02-12 22:44 by etl_backfill • Backfilled from existing medication fields

FDA Products & Applications (Animal Drugs @ FDA)

Official sponsor/proprietary-name/application-status records linked by active ingredient.

Product Sponsor Application Status Published
Sevoflurane
RX
Sevoflurane
Liquid • Inhalation
Label highlights
Official documents
Parnell Technologies Pty. Ltd. ANADA 200-830 Approved Feb 2, 2026
Petrem®
RX
Sevoflurane
Liquid (Solution) • Inhalation
Label highlights
Official documents
Piramal Pharma Ltd. ANADA 200-438 Approved Mar 14, 2024
Sevospire™
RX
Sevoflurane
Liquid • Inhalation
Label highlights
Official documents
Dechra Veterinary Products LLC ANADA 200-467 Approved Oct 14, 2022
SevoFlo®
RX
Sevoflurane
Liquid • Inhalation
Label highlights
Official documents
Zoetis Inc. NADA 141-103 Approved Jun 1, 2016

Data source: FDA Animal Drugs @ FDA (public search export).

What It's For (FDA Label Highlights)

Extracted from FDA Animal Drugs @ FDA product labeling. Always confirm details with your veterinarian.

Composition / specifications
250 mL sevoflurane
Dogs
Indication

For induction and maintenance of general anesthesia in dogs.

Dosage

For induction of surgical anesthesia: up to 7 percent sevoflurane. For maintenance of surgical anesthesia: 3.7 to 4percent sevoflurane with oxygen in the absence of premedication and 3.3 to 3.6 percent in the presence of premedication.

Limitations

FDA page: Open in Animal Drugs @ FDA

Species: Dog
Label highlights
Indication
For induction and maintenance of general anesthesia in dogs.
Dosage
For induction of surgical anesthesia: Up to 7 percent sevoflurane with oxygen. For maintenance of surgical anesthesia: 3.7 to 4 percent sevoflurane with oxygen in the absence of premedication and 3.3 to 3.6 percent in the presence of premedication
Limitations
Federal law restricts this drug to use by or on the order of a licensed veterinarian.

FDA page: Open in Animal Drugs @ FDA

Species: Dog
Composition / specifications
250 mL sevoflurane
Dogs
Indication
For induction and maintenance of general anesthesia in dogs.
Dosage
Induction: For mask induction using Sevoflurane alone, inspired concentrations of up to 7% sevoflurane with oxygen are employed to induce surgical anesthesia in the healthy dog. Maintenance: Surgical levels of anesthesia in the healthy dog may be maintained with inhaled concentrations of 3.7-4.0% sevoflurane in oxygen in the absence of premedication and 3.3-3.6% in the presence of premedication.
Limitations
Federal law restricts this drug to use by or on the order of a licensed veterinarian.

FDA page: Open in Animal Drugs @ FDA

Species: Dog
Dogs
Indication
SevoFlo is indicated for induction and maintenance of general anesthesia in dogs.
Dosage
For induction of surgical anesthesia: Up to 7 percent sevoflurane with oxygen. For maintenance of surgical anesthesia: 3.7 to 4 percent sevoflurane with oxygen in the absence of premedication and 3.3 to 3.6 percent in the presence of premedication.
Limitations
Federal law restricts this drug to use by or on the order of a licensed veterinarian. When using sevoflurane, patients should be continuously monitored and facilities for maintenance of patent airway, artificial ventilation, and oxygen supplementation must be immediately available

FDA page: Open in Animal Drugs @ FDA

Usage

SevoFlo is indicated for induction and maintenance of general anesthesia in dogs. For induction and maintenance of general anesthesia in dogs.

Source: FDA Animal Drugs @ FDA • Reference

Contraindications

Federal law restricts this drug to use by or on the order of a licensed veterinarian. When using sevoflurane, patients should be continuously monitored and facilities for maintenance of patent airway, artificial ventilation, and oxygen supplementation must be immediately available Federal law restricts this drug to use by or on the order of a licensed veterinarian.

Top Reported Reactions (openFDA)

De-duplicated reaction terms grouped by body system from FDA openFDA reports (not verified; does not prove causation).

Digestive
Loss of appetite (1) • Dog Diarrhea (1) • Cat Decreased appetite (1) • Dog Appetite loss (1) • Dog

Showing top 5 for Digestive.

Skin & allergy
Hair loss at application site (1) • Cat

Showing top 5 for Skin & allergy.

Neurologic
Focal seizure (1) • Cat Depression (1) • Dog

Showing top 5 for Neurologic.

Other
Trouble breathing (1) • Dog Fear/fearful (1) • Cat Excessive chewing, licking and/or grooming (1) • Dog Elevated serum alkaline phosphatase (1) • Dog Disorder of red blood cell NOS (1) • Cat
Show more (20)
Dilated pupils (1) • Cat Dehydration (1) • Dog Defect Unknown/Not Specified (1) • Cat Decreased drinking (1) • Dog Death (1) • Dog Burn (1) • Dog Bacterial skin infection NOS (1) • Dog Arthritis (1) • Dog Application site ulcer (1) • Cat Application site scratching (1) • Cat Application site scab (1) • Cat Application site pustule (1) • Dog Application site lesion (1) • Cat Application site bleeding (1) • Cat Allergic oedema (1) • Dog Acute renal failure (1) • Dog Acid-base disorder (1) • Dog Abnormal radiograph finding (1) • Dog Abnormal electrocardiogram (1) • Dog Abnormal cytology (1) • Dog

Showing top 5 for Other.

Data source: FDA openFDA Animal & Veterinary adverse event reports.

Adverse Event Case Summaries (openFDA)

These are individual FDA adverse event reports. They are unverified and do not prove the medication caused the reaction.

Dog, Bulldog - French, Male, 8 year, 12.428 kilogram • Drug: MSK, Unassigned, Respiratory (Inhalation) • Reactions: Decreased appetite, Decreased drinking, Tiredness (lethargy), Panting, Tense muscles… • Outcome: Recovered/Normal

  • Report ID: USA-USFDACVM-2025-US-074194
  • Serious AE: Yes
  • Treated For AE: Yes
  • Sex: Male
  • Age: 8.00 Year
  • Weight: 12.428 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Respiratory (Inhalation)
  • Form: Unassigned
Reactions Reported:
Decreased appetite Decreased drinking Tiredness (lethargy) Panting Tense muscles Seizure NOS Inappropriate defecation Inappropriate urination Unable to walk Proprioception deficit Generalised weakness Lameness Limb non-weight bearing Abnormal radiograph finding Medication error NOS
Outcomes: Recovered/Normal

Cat, Maine Coon, Male, 13 year, 6.58 kilogram • Drug: MSK, Unknown • Reactions: Twitching, Focal seizure, Death, Tiredness (lethargy) • Outcome: Died

  • Report ID: USA-USFDACVM-2025-US-074994
  • Serious AE: Yes
  • Treated For AE: No
  • Sex: Male
  • Age: 13.00 Year
  • Weight: 6.580 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Unknown
Reactions Reported:
Twitching Focal seizure Death Tiredness (lethargy)
Outcomes: Died

Dog, ['Sheepdog - Beauce (Beauceron)', 'Poodle (unspecified)'], Mixed, 35 kilogram • Drug: MSK, Solution, Respiratory (Inhalation) • Reactions: INEFFECTIVE, ANESTHESIA, Potency, Low • Outcome: Outcome Unknown

  • Report ID: SWE-USFDACVM-2025-SE-000005
  • Serious AE: Yes
  • Treated For AE: Yes
  • Sex: Mixed
  • Weight: 35.000 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Respiratory (Inhalation)
  • Form: Solution
Reactions Reported:
INEFFECTIVE, ANESTHESIA Potency, Low
Outcomes: Outcome Unknown

Cat, Domestic Shorthair, Female, 14 year, 3.65 kilogram • Drug: MSK, Unknown • Reactions: Hair loss at application site, Wobbliness, Not eating • Outcome: Ongoing

  • Report ID: USA-USFDACVM-2025-US-071193
  • Serious AE: No
  • Treated For AE: No
  • Sex: Female
  • Age: 14.00 Year
  • Weight: 3.650 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Unknown
Reactions Reported:
Hair loss at application site Wobbliness Not eating
Outcomes: Ongoing

Dog, Terrier - Bull - Staffordshire, Male, 14 month, 16.5 kilogram • Drug: MSK, Solution, Respiratory (Inhalation), Dose: 2 Other per animal • Reactions: Depression, Appetite loss, Application site pustule, Dehydration, Acute renal failure… • Outcome: Recovered/Normal

  • Report ID: DNK-USFDACVM-2025-DK-000007
  • Serious AE: Yes
  • Treated For AE: Yes
  • Sex: Male
  • Age: 14.00 Month
  • Weight: 16.500 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Respiratory (Inhalation)
  • Form: Solution
  • Dose: 2 Other per animal
Reactions Reported:
Depression Appetite loss Application site pustule Dehydration Acute renal failure Polyuria Polydipsia
Outcomes: Recovered/Normal

Dog, Siberian Husky, Female, 2 year, 24.1 kilogram • Drug: MSK, Solution, Respiratory (Inhalation) • Reactions: Gastrointestinal irritation, Painful urination, Haematuria • Outcome: Ongoing

  • Report ID: USA-USFDACVM-2025-US-064896
  • Serious AE: No
  • Treated For AE: Yes
  • Sex: Female
  • Age: 2.00 Year
  • Weight: 24.100 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Respiratory (Inhalation)
  • Form: Solution
Reactions Reported:
Gastrointestinal irritation Painful urination Haematuria
Outcomes: Ongoing

Data source: FDA openFDA Animal & Veterinary adverse event reports.

Overdose Information

No approved overdose-management text is linked yet. If overdose is suspected, contact a veterinarian or emergency clinic immediately.

Storage & Handling

No approved storage guidance is linked yet for this ingredient. Use manufacturer packaging and veterinary guidance for handling/storage.

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