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Roxee Meds Catalog

Spinosad, Milbemycin

Medication catalog facts with explicit FDA-approval, off-label, source-limited, and safety context.

Both Catalog complete FDA data linked Rx required Chewable Tablets Elanco US Inc. Official label facts Owner quick guide first
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Data freshness

Storefront facts
Catalog refreshed
Apr 22, 2026, 10:07 a.m.

These are the storefront facts Roxee uses on browse cards and quick facts.

FDA applications
FDA application data refreshed
May 5, 2026, 10:00 a.m.

Sponsor, product, and application records imported from Animal Drugs @ FDA.

Safety reports
Safety data refreshed
May 5, 2026, 10:01 a.m.

openFDA reaction terms and case summaries are supporting evidence, not proof of causality.

Source timing details
Source timing details
  • Storefront facts: Source Roxee | Refreshed Apr 22, 2026, 10:07 AM UTC
    The storefront fact projection used for browse cards and quick facts.
  • Animal Drugs @ FDA: Source FDA | Refreshed May 5, 2026, 10:00 AM UTC
    Applications/products are imported from FDA export data.
  • Animal Drugs @ FDA previews: Source FDA | Refreshed Feb 9, 2026, 3:05 AM UTC
    Label highlights/doc links are fetched from FDA preview endpoints.
  • Animal Drug Product Listing Directory (NDC): Source FDA | Refreshed May 5, 2026, 10:00 AM UTC
    Package/product NDCs from FDA’s electronic listing directory (XLS).
  • openFDA reaction terms: Source FDA openFDA | Refreshed May 5, 2026, 10:04 AM UTC
  • openFDA case summaries: Source FDA openFDA | Refreshed May 5, 2026, 10:04 AM UTC

Evidence

Reviewed / Updated / Sources

Reviewed by: Not available

Last reviewed: April 22, 2026

Updated: April 22, 2026, 10:06 AM UTC

Sources:
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Spinosad, Milbemycin

Spinosad, Milbemycin

Drug type: Generic ingredient • Branded profile • FDA branded products available

Both Chewable Tablets Rx required 100% storefront ready

Species: Both

Manufacturer: Elanco US Inc.

Medication Snapshot

Merged from the current Roxee medication system with field-level provenance, freshness, and completeness tracking.

Spinosad, Milbemycin

Trifexis™ Chewable Tablets kill fleas and are indicated for the prevention and treatment of flea infestations ( Ctenocephalides felis ), and the treatment and control of adult hookworm ( Ancylostoma caninum ), adult roundworm ( Toxocara canis and Toxascaris leonina ) and adult whipworm ( Trichuris vulpis ) infections in dogs and puppies 8 weeks of age or older and 5 pounds of body weight or greater. Trifexis™Chewable Tablets are indicated for the prevention of heartworm disease ( Dirofilaria immitis ). Species commonly shown: Both, Dog, No Use Class Stated Or Implied.

Generic name
Spinosad, Milbemycin
Brand names
Trifexis™, Trifexis
Manufacturer
Elanco US Inc.
Species
Both, Dog, No Use Class Stated Or Implied
Dosage forms
Chewable Tablets
Prescription
Prescription required
Completeness
100%
Validation
Complete
Brand names
Trifexis™ Trifexis
Dosage forms
Chewable Tablets

Indications / Uses

Trifexis™ Chewable Tablets kill fleas and are indicated for the prevention and treatment of flea infestations ( Ctenocephalides felis ), and the treatment and control of adult hookworm ( Ancylostoma caninum ), adult roundworm ( Toxocara canis and Toxascaris leonina ) and adult whipworm ( Trichuris vulpis ) infections in dogs and puppies 8 weeks of age or older and 5 pounds of body weight or greater. Trifexis™Chewable Tablets are indicated for the prevention of heartworm disease ( Dirofilaria immitis ).

Warnings / Contraindications

Federal (USA) law restricts this drug to use by or on the order of a licensed veterinarian. Treatment with fewer than 3 monthly doses after the last exposure to mosquitos may not provide complete heartworm prevention. Use with caution in breeding females. The safe use of TRIFEXIS in breeding males has not been evaluated. Use with caution in dogs with pre-existing epilepsy.

  • Federal (USA) law restricts this drug to use by or on the order of a licensed veterinarian. Treatment with fewer than 3 monthly doses after the last exposure to mosquitos may not provide complete heartworm prevention. Use with caution in breeding females. The safe use of TRIFEXIS in breeding males has not been evaluated. Use with caution in dogs with pre-existing epilepsy.

Side Effects

Top reported reactions (openFDA): Lack of efficacy (endoparasite) - heartworm, Emesis (multiple), Lethargy (see also Central nervous system depression in 'Neurological'), Shaking, Sleepiness - systemic disorder, Vomiting.

FAQ

Both, Dog, No Use Class Stated Or Implied

Yes. Roxee shows this as prescription-only.

Chewable Tablets

Related Conditions

Fleas (Flea Infestation) Heartworm Disease

Source Transparency

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Pet Owner Quick Guide

Start here first for the safest next-step summary before the deeper medication detail.

Used for:

Trifexis™ Chewable Tablets kill fleas and are indicated for the prevention and treatment of flea infestations ( Ctenocephalides felis ), and the treatment and control of adult hookworm ( Ancylostoma caninum ), adult roun...

Dosing note:

Exact dosing depends on your pet's species, weight, and health status. Use your veterinarian's instructions for the exact dose and schedule.

What to watch for:

  • Federal (USA) law restricts this drug to use by or on the order of a licensed veterinarian
  • Treatment with fewer than 3 monthly doses after the last exposure to mosquitos may not provide complete heartworm prevention
  • Use with caution in breeding females
  • The safe use of TRIFEXIS in breeding males has not been evaluated
  • Use with caution in dogs with pre-existing epilepsy
  • Vomiting (1 reports)
  • UNPALATABLE (1 reports)
  • very low energy (1 reports)

When to call the vet:

  • Repeated vomiting or diarrhea.
  • Severe lethargy (hard to wake, very low energy).
  • Collapse or fainting.
  • Trouble breathing.
  • Facial swelling or hives.
  • Blood in vomit or stool.

What to tell or ask your vet today:

  • Is this medicine the right fit for my pet’s current symptoms?
  • Which warning signs mean I should call back right away?
  • How should I handle missed doses or refusal to take the medicine?
Major cautions & emergency warning signs

Side effects to monitor:

  • Federal (USA) law restricts this drug to use by or on the order of a licensed veterinarian
  • Treatment with fewer than 3 monthly doses after the last exposure to mosquitos may not provide complete heartworm prevention
  • Use with caution in breeding females
  • The safe use of TRIFEXIS in breeding males has not been evaluated
  • Use with caution in dogs with pre-existing epilepsy

Most reported reactions:

  • Vomiting (1 reports)
  • UNPALATABLE (1 reports)
  • Tiredness (lethargy) (1 reports)

Emergency warning signs:

  • Repeated vomiting or diarrhea.
  • Severe lethargy (hard to wake, very low energy).
  • Collapse or fainting.
  • Trouble breathing.
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Quick Facts

Official label facts first, then secondary summaries. Marketing content is separated below.

Species: Both
Manufacturer: Elanco US Inc.
Form: Chewable Tablets
Identifiers:
NADA: 141321 NDC Package: 58198-0042-1 NDC Package: 58198-0042-6 NDC Package: 58198-0043-1 NDC Package: 58198-0043-6 NDC Package: 58198-0044-1 NDC Package: 58198-0044-6 NDC Package: 58198-0045-1 NDC Package: 58198-0045-6 NDC Package: 58198-0046-1 NDC Package: 58198-0046-6 NDC Product: 58198
Source metadata:

Warnings / Contraindications

Federal (USA) law restricts this drug to use by or on the order of a licensed veterinarian. Treatment with fewer than 3 monthly doses after the last exposure to mosquitos may not provide complete heartworm prevention. Use with caution in breeding females. The safe use of TRIFEXIS in breeding males has not been evaluated. Use with caution in dogs with pre-existing epilepsy.

  • High: Federal (USA) law restricts this drug to use by or on the order of a licensed veterinarian. Treatment with fewer than 3 monthly doses after the last exposure to mosquitos may not provide complete heartworm prevention. Use with caution in breeding females. The safe use of TRIFEXIS in breeding males has not been evaluated. Use with caution in dogs with pre-existing epilepsy.
Source metadata:

Adverse Reactions

Snapshot first, detailed rows second. This section summarizes signal data and is not a diagnosis.

Tap or hover a reaction to see what it means in plain language.

Tracked signals
13
Reported cases
10
Serious reports
1
Species represented
1
Grouped by Body System
Digestive (1) · Vomiting Neurologic (2) · Tiredness (lethargy), Lethargy (see also Central nervous system depression in 'Neurological') Behavior (1) · Behavioral disorder (unspecified) Effectiveness (1) · Lack of efficacy (endoparasite) - heartworm Other (8) · UNPALATABLE, Shaking, Overdose
Most Reported Reactions
Reaction Body system Cases Species Serious cases
Digestive 1 Dog 1
Other 1 Dog 0
Neurologic 1 Dog 0
Other 1 Dog 0
Other 1 Dog 0
Effectiveness 1 Dog 0
Other 1 Dog 0
Other 1 Dog 0

Species coverage: Dog (13)

View detailed reaction table
Reaction Body system Species Seriousness Frequency Reports
Digestive Dog Serious - 1
Other Dog Non-serious - 1
Neurologic Dog Non-serious - 1
Other Dog Non-serious - 1
Other Dog Non-serious - 1
Effectiveness Dog Non-serious - 1
Other Dog Non-serious - 1
Other Dog Non-serious - 1
Behavior Dog Non-serious - 1
Other Dog Non-serious - 1
Other Dog Unknown - -
Neurologic Dog Unknown - -
Other Dog Unknown - -
Source metadata:

Documents

Owner handouts and official technical documents open on-page first, with the original source still one click away.

Owner handouts

0
No owner handouts linked yet.

Official label / PI

1

SPL

2

FOI

1

TRIFEXIS N141321C0060.pdf

Official label / PI · Labeling

Open original

Trifexis™

SPL · SPL

Open original
FDA Structured Product Label

Trifexis™

Rendered from Roxee's cached FDA SPL package contents for on-page reading. Use Open original for the raw FDA ZIP/XML source.

Sponsor
Elanco US Inc.
NADA
141-321
Status
RX
Form
Chewable Tablets
Route
Oral
Species
Dog, No Use Class Stated Or Implied
Composition / specifications
The product is available in five tablet strengths:
140 mg spinosad and 2.3 mg milbemycin oxime
270 mg spinosad and 4.5 mg milbemycin oxime
560 mg spinosad and 9.3 mg milbemycin oxime
810 mg spinosad and 13.5 mg milbemycin oxime
1620 mg spinosad and 27 mg milbemycin oxime

Dogs and Puppies (8 Weeks and Older and 5 Lbs or Greater)

Indication
Trifexis™ Chewable Tablets kill fleas and are indicated for the prevention and treatment of flea infestations (Ctenocephalides felis), and the treatment and control of adult hookworm (Ancylostoma caninum), adult roundworm (Toxocara canis and Toxascaris leonina) and adult whipworm (Trichuris vulpis) infections in dogs and puppies 8 weeks of age or older and 5 pounds of body weight or greater.
Dosage
Given orally, once a month at a minimum dosage of 13.5 mg/lb (30 mg/kg) spinosad and 0.2 mg/lb (0.5 mg/kg) milbemycin oxime body weight.
Limitations
Federal (USA) law restricts this drug to use by or on the order of a licensed veterinarian. Treatment with fewer than 3 monthly doses after the last exposure to mosquitos may not provide complete heartworm prevention. Use with caution in breeding females. The safe use of TRIFEXIS in breeding males has not been evaluated. Use with caution in dogs with pre-existing epilepsy.
Indication
Trifexis™Chewable Tablets are indicated for the prevention of heartworm disease (Dirofilaria immitis).
Dosage
Given orally, once a month at a minimum dosage of 13.5 mg/lb (30 mg/kg) spinosad and 0.2 mg/lb (0.5 mg/kg) milbemycin oxime body weight.
Limitations
Federal (USA) law restricts this drug to use by or on the order of a licensed veterinarian. Treatment with fewer than 3 monthly doses after the last exposure to mosquitos may not provide complete heartworm prevention. Use with caution in breeding females. The safe use of TRIFEXIS in breeding males has not been evaluated. Use with caution in dogs with pre-existing epilepsy.

Trifexis SPL

SPL · Structured Product Label

Open original
FDA Structured Product Label XML for Trifexis. Use the source link for the full official labeling record.

UCM252248.pdf

FOI · FOI

Open original
Source metadata:
Veterinary reference (advanced)

Canonical medication sections are above. This legacy block remains available for deeper cross-reference without cluttering the primary workflow.

At a Glance

Quick facts and links to official labeling and safety signals.

Data freshness
  • Storefront facts: Source Roxee | Refreshed Apr 22, 2026, 10:07 AM UTC
    The storefront fact projection used for browse cards and quick facts.
  • Animal Drugs @ FDA: Source FDA | Refreshed May 5, 2026, 10:00 AM UTC
    Applications/products are imported from FDA export data.
  • Animal Drugs @ FDA previews: Source FDA | Refreshed Feb 9, 2026, 3:05 AM UTC
    Label highlights/doc links are fetched from FDA preview endpoints.
  • Animal Drug Product Listing Directory (NDC): Source FDA | Refreshed May 5, 2026, 10:00 AM UTC
    Package/product NDCs from FDA’s electronic listing directory (XLS).
  • openFDA reaction terms: Source FDA openFDA | Refreshed May 5, 2026, 10:04 AM UTC
  • openFDA case summaries: Source FDA openFDA | Refreshed May 5, 2026, 10:04 AM UTC
Official (FDA)
Identity: Generic ingredient • FDA branded products available
Official FDA brands: Trifexis
Manufacturer mapping: Elanco US Inc.
Case-reported brands (openFDA): MSK
Catalog species: Both • FDA-labeled species: Dog
Rx/OTC: RX
Form/route: Chewable Tablets • Oral
Applications: NADA 141-321
NDC: Packages 58198-0042-1 58198-0042-6 58198-0043-1 58198-0043-6 58198-0044-1 58198-0044-6 • Products 58198
Documents: 2 (FOI: 1) • SPL: 1 • Label highlights • Official documents
Safety (openFDA)
Top reactions: Dog 10 • Cat 0 • View
Case summaries: 5 (showing 5) • View
openFDA reports are unverified and do not prove causation.
Explore
Linked using: Fda_Label (0.95), Fda_Label (0.95)
Diagnosis Codes
ICD10_CM: B74.8 ICD10_CM: B88.1
Other filariases

Counseling and Monitoring Highlights

Global Pet owner/Vet mode is controlled in the header. This section avoids duplicate in-page persona tabs.

Owner-facing counseling points
  • Federal (USA) law restricts this drug to use by or on the order of a licensed veterinarian. Treatment with fewer than 3 monthly doses after the last exposure to mosquitos may not provide complete heartworm prevention. Use with caution in breeding females. The safe use of TRIFEXIS in breeding males has not been evaluated. Use with caution in dogs with pre-existing epilepsy. (Contraindication, High)
Top reaction signals
Vomiting (1) UNPALATABLE (1) Tiredness (lethargy) (1) Shaking (1) Overdose (1) Lack of efficacy (endoparasite) - heartworm (1) Falling (1) Difficulty standing (1)

Identifiers & Packages

Normalized identifiers (NDC/NADA/ANADA) and package metadata from regulator listings.

Identifiers
NADA: 141321 NDC Package: 58198-0042-1 NDC Package: 58198-0042-6 NDC Package: 58198-0043-1 NDC Package: 58198-0043-6 NDC Package: 58198-0044-1 NDC Package: 58198-0044-6 NDC Package: 58198-0045-1 NDC Package: 58198-0045-6 NDC Package: 58198-0046-1 NDC Package: 58198-0046-6 NDC Product: 58198
Package NDC Product NDC Form / Route Status
58198-0042-1 58198 -
58198-0042-6 58198 -
58198-0043-1 58198 -
58198-0043-6 58198 -
58198-0044-1 58198 -
58198-0044-6 58198 -
58198-0045-1 58198 -
58198-0045-6 58198 -
58198-0046-1 58198 -
58198-0046-6 58198 -

Enriched Documents

Documents are tiered by source trust: Official, Clinical, Manufacturer, Marketing.

  • Trifexis SPL • Structured Product Label • Official
    FDA Structured Product Label from the electronic animal drug product listing directory.
  • TRIFEXIS N141321C0060.pdf • Official label • Official • May 17, 2021
    FDA official labeling for application 141321
  • UCM252248.pdf • FOI summary • Official • May 17, 2021
    FDA FOI summary for application 141321

Data Sources & Change Log

Every non-trivial field is expected to include provenance and update timestamps.

Official 34 Clinical 2 Manufacturer 0 Marketing 0
Current Field Facts
  • side_effects: Top reported reactions (openFDA): Lack of efficacy (endoparasite) - heartworm, Emesis (multiple), Lethargy (see also Central nervous system depression in 'Neur… (Clinical, 2026-04-15)
  • side_effects: Top reported reactions (openFDA): Lack of efficacy (endoparasite) - heartworm, Emesis (multiple), Lethargy (see also Central nervous system depression in 'Neur… (Clinical, 2026-04-11)
  • contraindications: Federal (USA) law restricts this drug to use by or on the order of a licensed veterinarian. Treatment with fewer than 3 monthly doses after the last exposure t… (Official, 2026-04-22)
  • indications: Indicated for the prevention of heartworm disease ( Dirofilaria immitis). Trifexis™ Chewable Tablets kill fleas and are indicated for the prevention and treatm… (Official, 2026-05-05)
  • indications: Indicated for the prevention of heartworm disease ( Dirofilaria immitis). Trifexis™ Chewable Tablets kill fleas and are indicated for the prevention and treatm… (Official, 2026-05-03)
  • indications: Indicated for the prevention of heartworm disease ( Dirofilaria immitis). Trifexis™ Chewable Tablets kill fleas and are indicated for the prevention and treatm… (Official, 2026-05-02)
  • indications: Indicated for the prevention of heartworm disease ( Dirofilaria immitis). Trifexis™ Chewable Tablets kill fleas and are indicated for the prevention and treatm… (Official, 2026-04-29)
  • indications: Indicated for the prevention of heartworm disease ( Dirofilaria immitis). Trifexis™ Chewable Tablets kill fleas and are indicated for the prevention and treatm… (Official, 2026-04-28)
  • indications: Indicated for the prevention of heartworm disease ( Dirofilaria immitis). Trifexis™ Chewable Tablets kill fleas and are indicated for the prevention and treatm… (Official, 2026-04-27)
  • indications: Indicated for the prevention of heartworm disease ( Dirofilaria immitis). Trifexis™ Chewable Tablets kill fleas and are indicated for the prevention and treatm… (Official, 2026-04-26)
  • indications: Indicated for the prevention of heartworm disease ( Dirofilaria immitis). Trifexis™ Chewable Tablets kill fleas and are indicated for the prevention and treatm… (Official, 2026-04-25)
  • indications: Indicated for the prevention of heartworm disease ( Dirofilaria immitis). Trifexis™ Chewable Tablets kill fleas and are indicated for the prevention and treatm… (Official, 2026-04-22)
  • manufacturer_name: Elanco US Inc. (Official, 2026-05-05)
  • manufacturer_name: Elanco US Inc. (Official, 2026-05-03)
  • manufacturer_name: Elanco US Inc. (Official, 2026-05-02)
  • manufacturer_name: Elanco US Inc. (Official, 2026-04-29)
  • manufacturer_name: Elanco US Inc. (Official, 2026-04-28)
  • manufacturer_name: Elanco US Inc. (Official, 2026-04-27)
  • manufacturer_name: Elanco US Inc. (Official, 2026-04-26)
  • manufacturer_name: Elanco US Inc. (Official, 2026-04-25)
Recent Revisions
  • side_effects updated 2026-04-22 10:07 by etl_backfill • Backfilled from existing medication fields
  • contraindications updated 2026-04-22 10:07 by etl_backfill • Backfilled from existing medication fields
  • usage updated 2026-04-22 10:07 by etl_backfill • Backfilled from existing medication fields
  • side_effects updated 2026-04-15 10:04 by etl_backfill • Backfilled from existing medication fields
  • side_effects updated 2026-04-11 10:05 by etl_backfill • Backfilled from existing medication fields
  • side_effects updated 2026-02-12 22:44 by etl_backfill • Backfilled from existing medication fields

FDA Products & Applications (Animal Drugs @ FDA)

Official sponsor/proprietary-name/application-status records linked by active ingredient.

Product Sponsor Application Status Published
Trifexis™
RX
Milbemycin Oxime Spinosad
Chewable Tablets • Oral
Label highlights
Official documents
Elanco US Inc. NADA 141-321 Approved May 17, 2021

Data source: FDA Animal Drugs @ FDA (public search export).

What It's For (FDA Label Highlights)

Extracted from FDA Animal Drugs @ FDA product labeling. Always confirm details with your veterinarian.

Species: Dog, No Use Class Stated Or Implied
Composition / specifications
The product is available in five tablet strengths:
140 mg spinosad and 2.3 mg milbemycin oxime
270 mg spinosad and 4.5 mg milbemycin oxime
560 mg spinosad and 9.3 mg milbemycin oxime
810 mg spinosad and 13.5 mg milbemycin oxime
1620 mg spinosad and 27 mg milbemycin oxime
Dogs and Puppies (8 Weeks and Older and 5 Lbs or Greater)
Indication
Trifexis™ Chewable Tablets kill fleas and are indicated for the prevention and treatment of flea infestations (Ctenocephalides felis), and the treatment and control of adult hookworm (Ancylostoma caninum), adult roundworm (Toxocara canis and Toxascaris leonina) and adult whipworm (Trichuris vulpis) infections in dogs and puppies 8 weeks of age or older and 5 pounds of body weight or greater.
Dosage
Given orally, once a month at a minimum dosage of 13.5 mg/lb (30 mg/kg) spinosad and 0.2 mg/lb (0.5 mg/kg) milbemycin oxime body weight.
Limitations
Federal (USA) law restricts this drug to use by or on the order of a licensed veterinarian. Treatment with fewer than 3 monthly doses after the last exposure to mosquitos may not provide complete heartworm prevention. Use with caution in breeding females. The safe use of TRIFEXIS in breeding males has not been evaluated. Use with caution in dogs with pre-existing epilepsy.
Indication
Trifexis™Chewable Tablets are indicated for the prevention of heartworm disease (Dirofilaria immitis).
Dosage
Given orally, once a month at a minimum dosage of 13.5 mg/lb (30 mg/kg) spinosad and 0.2 mg/lb (0.5 mg/kg) milbemycin oxime body weight.
Limitations
Federal (USA) law restricts this drug to use by or on the order of a licensed veterinarian. Treatment with fewer than 3 monthly doses after the last exposure to mosquitos may not provide complete heartworm prevention. Use with caution in breeding females. The safe use of TRIFEXIS in breeding males has not been evaluated. Use with caution in dogs with pre-existing epilepsy.

FDA page: Open in Animal Drugs @ FDA

Usage

Trifexis™ Chewable Tablets kill fleas and are indicated for the prevention and treatment of flea infestations ( Ctenocephalides felis ), and the treatment and control of adult hookworm ( Ancylostoma caninum ), adult roundworm ( Toxocara canis and Toxascaris leonina ) and adult whipworm ( Trichuris vulpis ) infections in dogs and puppies 8 weeks of age or older and 5 pounds of body weight or greater. Trifexis™Chewable Tablets are indicated for the prevention of heartworm disease ( Dirofilaria immitis ).

Source: FDA Animal Drugs @ FDA • Reference

Contraindications

Federal (USA) law restricts this drug to use by or on the order of a licensed veterinarian. Treatment with fewer than 3 monthly doses after the last exposure to mosquitos may not provide complete heartworm prevention. Use with caution in breeding females. The safe use of TRIFEXIS in breeding males has not been evaluated. Use with caution in dogs with pre-existing epilepsy.

Top Reported Reactions (openFDA)

De-duplicated reaction terms grouped by body system from FDA openFDA reports (not verified; does not prove causation).

Digestive
Vomiting (1) • Dog

Showing top 5 for Digestive.

Neurologic
Tiredness (1) • Dog Tiredness (lethargy) • Dog

Showing top 5 for Neurologic.

Behavior
Behavioral disorder (1) • Dog

Showing top 5 for Behavior.

Effectiveness
Lack of efficacy (endoparasite) - heartworm (1) • Dog

Showing top 5 for Effectiveness.

Other
UNPALATABLE (1) • Dog Shaking (1) • Dog Overdose (1) • Dog Falling (1) • Dog Difficulty standing (1) • Dog
Show more (2)
Accidental exposure (1) • Dog Sleepiness - systemic disorder • Dog

Showing top 5 for Other.

Data source: FDA openFDA Animal & Veterinary adverse event reports.

Adverse Event Case Summaries (openFDA)

These are individual FDA adverse event reports. They are unverified and do not prove the medication caused the reaction.

Dog, ['Chihuahua', 'Dachshund (unspecified)'], Male, 7 year, 9.072 kilogram • Drug: MSK, Tablet, chewable, Oral, Dose: 1 tablet per animal • Reactions: Behavioral disorder (unspecified), UNPALATABLE • Outcome: Outcome Unknown

  • Report ID: USA-USFDACVM-2025-US-074717
  • Serious AE: No
  • Treated For AE: No
  • Sex: Male
  • Age: 7.00 Year
  • Weight: 9.072 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Oral
  • Form: Tablet, chewable
  • Dose: 1 tablet per animal
Reactions Reported:
Behavioral disorder (unspecified) UNPALATABLE
Outcomes: Outcome Unknown

Dog, ['Boxer (German Boxer)', 'Crossbred Canine/dog'], Male, 6 year, 28.5 kilogram • Drug: MSK, Tablet, chewable, Oral, Dose: 1 dose per animal, Frequency: 1 per month • Reactions: Lack of efficacy (endoparasite) - heartworm • Outcome: Outcome Unknown

  • Report ID: USA-USFDACVM-2025-US-074715
  • Serious AE: No
  • Treated For AE: Yes
  • Sex: Male
  • Age: 6.00 Year
  • Weight: 28.500 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Oral
  • Form: Tablet, chewable
  • Dose: 1 dose per animal
  • Frequency: 1 per month
Reactions Reported:
Lack of efficacy (endoparasite) - heartworm
Outcomes: Outcome Unknown

Dog, ['Shepherd Dog - Australian', 'Retriever - Labrador', 'Poodle (unspecified)'], Female, 2 year, 15.87 kilogram • Drug: MSK, Tablet, chewable, Oral, Dose: 4 tablet per animal • Reactions: Tiredness (lethargy), Vomiting, Overdose • Outcome: Outcome Unknown

  • Report ID: USA-USFDACVM-2025-US-074912
  • Serious AE: No
  • Treated For AE: No
  • Sex: Female
  • Age: 2.00 Year
  • Weight: 15.870 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Oral
  • Form: Tablet, chewable
  • Dose: 4 tablet per animal
Reactions Reported:
Tiredness (lethargy) Vomiting Overdose
Outcomes: Outcome Unknown

Dog, Shepherd Dog - German, Female, 8 week, 4.08 kilogram • Drug: MSK, Tablet, chewable, Oral, Dose: 1 tablet per animal • Reactions: Vomiting, Difficulty standing, Tiredness (lethargy), Shaking, Falling… • Outcome: Ongoing

  • Report ID: USA-USFDACVM-2025-US-074182
  • Serious AE: No
  • Treated For AE: No
  • Sex: Female
  • Age: 8.00 Week
  • Weight: 4.080 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Oral
  • Form: Tablet, chewable
  • Dose: 1 tablet per animal
Reactions Reported:
Vomiting Difficulty standing Tiredness (lethargy) Shaking Falling Accidental exposure Overdose
Outcomes: Ongoing

Dog, Dog (unknown), Male, 5 year, 29.7 kilogram • Drug: MSK, Tablet, chewable, Oral, Dose: 1 tablet per animal • Reactions: Vomiting, UNPALATABLE • Outcome: Outcome Unknown

  • Report ID: USA-USFDACVM-2025-US-073646
  • Serious AE: No
  • Treated For AE: No
  • Sex: Male
  • Age: 5.00 Year
  • Weight: 29.700 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Oral
  • Form: Tablet, chewable
  • Dose: 1 tablet per animal
Reactions Reported:
Vomiting UNPALATABLE
Outcomes: Outcome Unknown

Data source: FDA openFDA Animal & Veterinary adverse event reports.

Overdose Information

No approved overdose-management text is linked yet. If overdose is suspected, contact a veterinarian or emergency clinic immediately.

Storage & Handling

No approved storage guidance is linked yet for this ingredient. Use manufacturer packaging and veterinary guidance for handling/storage.

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