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Roxee Meds Catalog

Velagliflozin Proline Monohydrate

Medication catalog facts with explicit FDA-approval, off-label, source-limited, and safety context.

Both Catalog complete FDA data linked Sources vary Rx required Solution Boehringer Ingelheim Animal Health USA Inc. Official label facts Owner quick guide first
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Source variance noted. Roxee found source differences in non-clinical fields such as brand, manufacturer, source URL, or display metadata. Core owner guidance and official source links are still available.
Source variance fields
  • Active ingredients (Medication ingredients)

Data freshness

Storefront facts
Catalog refreshed
May 5, 2026, 10:07 a.m.

These are the storefront facts Roxee uses on browse cards and quick facts.

FDA applications
FDA application data refreshed
May 5, 2026, 10:00 a.m.

Sponsor, product, and application records imported from Animal Drugs @ FDA.

Safety reports
Safety data refreshed
May 5, 2026, 10:01 a.m.

openFDA reaction terms and case summaries are supporting evidence, not proof of causality.

Source timing details
Source timing details
  • Storefront facts: Source Roxee | Refreshed May 5, 2026, 10:07 AM UTC
    The storefront fact projection used for browse cards and quick facts.
  • Animal Drug Product Listing Directory (NDC): Source FDA | Refreshed May 5, 2026, 10:00 AM UTC
    Package/product NDCs from FDA’s electronic listing directory (XLS).
  • openFDA reaction terms: Source FDA openFDA | Refreshed May 5, 2026, 10:04 AM UTC
  • openFDA case summaries: Source FDA openFDA | Refreshed May 5, 2026, 10:04 AM UTC

Evidence

Reviewed / Updated / Sources

Reviewed by: Not available

Last reviewed: April 15, 2026

Updated: April 15, 2026, 10:04 AM UTC

Sources:
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Velagliflozin Proline Monohydrate

Velagliflozin Proline Monohydrate

Drug type: Generic ingredient • Branded profile • FDA branded products available

Both Solution Rx required 100% storefront ready

Species: Both

Manufacturer: Boehringer Ingelheim Animal Health USA Inc.

Medication Snapshot

Merged from the current Roxee medication system with field-level provenance, freshness, and completeness tracking.

Velagliflozin Proline Monohydrate

Senvelgo (velagliflozin oral solution) is approved in cats for control of hyperglycemia associated with diabetes mellitus. Species commonly shown: Cats.

Generic name
Velagliflozin Proline Monohydrate
Brand names
Senvelgo
Medication class
branded
Manufacturer
Boehringer Ingelheim Animal Health USA Inc.
Species
Cats
Dosage forms
Solution
Strengths
15 mg/mL
Prescription
Prescription required
Completeness
100%
Validation
Complete
Brand names
Senvelgo
Dosage forms
Solution
Strengths
15 mg/mL

Indications / Uses

Senvelgo (velagliflozin oral solution) is approved in cats for control of hyperglycemia associated with diabetes mellitus.

Administration / How To Give

Give Senvelgo by mouth once daily at approximately the same time each day, with or without food, as directed by a veterinarian.

Warnings / Contraindications

Do not use Senvelgo in cats with diabetes mellitus who have previously been treated with insulin, are receiving insulin, or have insulin-dependent diabetes mellitus; do not start it in cats that are anorexic, dehydrated, or lethargic.

  • Cats treated with Senvelgo may be at increased risk of diabetic ketoacidosis or euglycemic diabetic ketoacidosis, which can result in death and requires prompt veterinary treatment.

Side Effects

Top reported reactions (openFDA): Overdose, Diarrhoea, Vomiting, Hypersalivation, Wound, Dermal cyst(s).

FAQ

Cats

Yes. Roxee shows this as prescription-only.

Solution

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Pet Owner Quick Guide

Start here first for the safest next-step summary before the deeper medication detail.

Roxee still has limited plain-language guidance for this medication. Use the official documents and your veterinarian's instructions for product-specific details.

Used for:

Your vet decides this. Here's what owners typically ask/watch for.

Dosing note:

Exact dosing depends on your pet's species, weight, and health status. Use your veterinarian's instructions for the exact dose and schedule.

What to watch for:

  • Ketosis (1 reports)
  • Increased urine concentration (1 reports)
  • Hypotension (1 reports)

When to call the vet:

  • Repeated vomiting or diarrhea.
  • Severe lethargy (hard to wake, very low energy).
  • Collapse or fainting.
  • Trouble breathing.
  • Facial swelling or hives.
  • Blood in vomit or stool.

What to tell or ask your vet today:

  • Is this medicine the right fit for my pet’s current symptoms?
  • Which warning signs mean I should call back right away?
  • How should I handle missed doses or refusal to take the medicine?
Major cautions & emergency warning signs

Side effects to monitor:

  • Ketosis
  • Increased urine concentration
  • Hypotension

Most reported reactions:

  • Ketosis (1 reports)
  • Increased urine concentration (1 reports)
  • Hypotension (1 reports)

Emergency warning signs:

  • Repeated vomiting or diarrhea.
  • Severe lethargy (hard to wake, very low energy).
  • Collapse or fainting.
  • Trouble breathing.
Talk to a Vet / Find a Vet Near You Start Symptom Intake

Quick Facts

Official label facts first, then secondary summaries. Marketing content is separated below.

Species: Both
Manufacturer: Boehringer Ingelheim Animal Health USA Inc.
Identifiers:
NDC Package: 0010-4614-01 NDC Package: 0010-4614-02 NDC Product: 0010

Adverse Reactions

Snapshot first, detailed rows second. This section summarizes signal data and is not a diagnosis.

Tap or hover a reaction to see what it means in plain language.

Tracked signals
32
Reported cases
32
Serious reports
9
Species represented
2
Grouped by Body System
Digestive (3) · Drooling, Diarrhea, Bloody diarrhoea Behavior (1) · Behavioral disorder (unspecified) Effectiveness (2) · Lack of efficacy - NOS, Lack of efficacy (ectoparasite) - flea Other (26) · Ketosis, Ketonuria, Increased weight
Most Reported Reactions
Reaction Body system Cases Species Serious cases
Other 1 Cat 1
Other 1 Cat 1
Other 1 Cat 1
Other 1 Cat 1
Other 1 Cat 1
Digestive 1 Cat 1
Other 1 Cat 1
Other 1 Cat 1

Species coverage: Cat (29) Dog (3)

View detailed reaction table
Reaction Body system Species Seriousness Frequency Reports
Effectiveness Cat Non-serious - 1
Effectiveness Cat Non-serious - 1
Other Cat Serious - 1
Other Cat Non-serious - 1
Other Cat Non-serious - 1
Other Cat Serious - 1
Other Dog Non-serious - 1
Other Cat Serious - 1
Other Cat Serious - 1
Other Cat Non-serious - 1
Other Cat Non-serious - 1
Other Cat Non-serious - 1
Other Cat Non-serious - 1
Other Cat Serious - 1
Other Dog Non-serious - 1
Other Cat Non-serious - 1
Other Cat Non-serious - 1
Other Cat Non-serious - 1
Other Cat Non-serious - 1
Other Cat Non-serious - 1
Digestive Cat Non-serious - 1
Digestive Cat Serious - 1
Other Cat Serious - 1
Other Cat Non-serious - 1
Other Cat Non-serious - 1
Other Cat Serious - 1
Other Cat Non-serious - 1
Other Cat Non-serious - 1
Digestive Cat Non-serious - 1
Other Dog Non-serious - 1
Behavior Cat Serious - 1
Other Cat Non-serious - 1
Source metadata:

Documents

Owner handouts and official technical documents open on-page first, with the original source still one click away.

Owner handouts

0
No owner handouts linked yet.

Official label / PI

4

SPL

1

FOI

1

Animal Drugs @ FDA search portal

Official label / PI · Official label

Open original

This source does not expose a safe inline preview. Use the original source link for the full document.

Official FDA veterinary drug portal.

FDA Owner Guidance for Diabetes Drugs in Cats

Official label / PI · Safety communication

Open original

This source does not expose a safe inline preview. Use the original source link for the full document.

FDA owner-facing guidance for Bexacat and Senvelgo in diabetic cats.

FDA Dear Veterinarian Letter for Senvelgo

Official label / PI · Safety communication

Open original

This source does not expose a safe inline preview. Use the original source link for the full document.

FDA safety communication for veterinarians using Senvelgo.

FDA CVM Warning Letter (Senvelgo context)

Official label / PI · Safety communication

Open original

This source does not expose a safe inline preview. Use the original source link for the full document.

Official FDA communication referencing Senvelgo and sponsor.

Senvelgo SPL

SPL · Structured Product Label

Open original
FDA Structured Product Label XML for Senvelgo. Use the source link for the full official labeling record.

Senvelgo FOI Summary (FDA)

FOI · FOI summary

Open original
Source metadata:
Veterinary reference (advanced)

Canonical medication sections are above. This legacy block remains available for deeper cross-reference without cluttering the primary workflow.

At a Glance

Quick facts and links to official labeling and safety signals.

Data freshness
  • Storefront facts: Source Roxee | Refreshed May 5, 2026, 10:07 AM UTC
    The storefront fact projection used for browse cards and quick facts.
  • Animal Drug Product Listing Directory (NDC): Source FDA | Refreshed May 5, 2026, 10:00 AM UTC
    Package/product NDCs from FDA’s electronic listing directory (XLS).
  • openFDA reaction terms: Source FDA openFDA | Refreshed May 5, 2026, 10:04 AM UTC
  • openFDA case summaries: Source FDA openFDA | Refreshed May 5, 2026, 10:04 AM UTC
Official (FDA)
Identity: Generic ingredient • FDA branded products available
Official FDA brands: Senvelgo
Manufacturer mapping: Boehringer Ingelheim Animal Health USA Inc.
Case-reported brands (openFDA): MSK
Catalog species: Both
NDC: Packages 0010-4614-01 0010-4614-02 • Products 0010
Safety (openFDA)
Top reactions: Dog 0 • Cat 40 • View
Case summaries: 21 (showing 8) • View
openFDA reports are unverified and do not prove causation.
Diagnosis Codes

Diagnosis-code mappings are not available for this medication yet.

Counseling and Monitoring Highlights

Global Pet owner/Vet mode is controlled in the header. This section avoids duplicate in-page persona tabs.

Top reaction signals
Ketosis (1) Increased urine concentration (1) Hypotension (1) Hypokalaemia (1) Glucosuria (1) Diarrhea (1) Diabetic ketoacidosis (1) Death by euthanasia (1)

Identifiers & Packages

Normalized identifiers (NDC/NADA/ANADA) and package metadata from regulator listings.

Identifiers
NDC Package: 0010-4614-01 NDC Package: 0010-4614-02 NDC Product: 0010
Package NDC Product NDC Form / Route Status
0010-4614-01 0010 -
0010-4614-02 0010 -

Enriched Documents

Documents are tiered by source trust: Official, Clinical, Manufacturer, Marketing.

Data Sources & Change Log

Every non-trivial field is expected to include provenance and update timestamps.

Official 43 Clinical 83 Manufacturer 0 Marketing 0
Current Field Facts
  • monitoring: Monitor blood glucose and ketones, hydration status, appetite, and clinical response at regular intervals. (Clinical, 2026-05-01)
  • monitoring: Monitor blood glucose and ketones, hydration status, appetite, and clinical response at regular intervals. (Clinical, 2026-04-30)
  • monitoring: Monitor blood glucose and ketones, hydration status, appetite, and clinical response at regular intervals. (Clinical, 2026-04-21)
  • monitoring: Monitor blood glucose and ketones, hydration status, appetite, and clinical response at regular intervals. (Clinical, 2026-04-21)
  • monitoring: Monitor blood glucose and ketones, hydration status, appetite, and clinical response at regular intervals. (Clinical, 2026-04-20)
  • monitoring: Monitor blood glucose and ketones, hydration status, appetite, and clinical response at regular intervals. (Clinical, 2026-04-20)
  • monitoring: Monitor blood glucose and ketones, hydration status, appetite, and clinical response at regular intervals. (Clinical, 2026-04-19)
  • monitoring: Monitor blood glucose and ketones, hydration status, appetite, and clinical response at regular intervals. (Clinical, 2026-04-19)
  • monitoring: Monitor blood glucose and ketones, hydration status, appetite, and clinical response at regular intervals. (Clinical, 2026-04-17)
  • monitoring: Monitor blood glucose and ketones, hydration status, appetite, and clinical response at regular intervals. (Clinical, 2026-04-17)
  • monitoring: Monitor blood glucose and ketones, hydration status, appetite, and clinical response at regular intervals. (Clinical, 2026-04-16)
  • monitoring: Monitor blood glucose and ketones, hydration status, appetite, and clinical response at regular intervals. (Clinical, 2026-04-16)
  • monitoring: Monitor blood glucose and ketones, hydration status, appetite, and clinical response at regular intervals. (Clinical, 2026-04-16)
  • monitoring: Monitor blood glucose and ketones, hydration status, appetite, and clinical response at regular intervals. (Clinical, 2026-04-15)
  • monitoring: Monitor blood glucose and ketones, hydration status, appetite, and clinical response at regular intervals. (Clinical, 2026-04-15)
  • monitoring: Monitor blood glucose and ketones, hydration status, appetite, and clinical response at regular intervals. (Clinical, 2026-04-14)
  • monitoring: Monitor blood glucose and ketones, hydration status, appetite, and clinical response at regular intervals. (Clinical, 2026-04-12)
  • monitoring: Monitor blood glucose and ketones, hydration status, appetite, and clinical response at regular intervals. (Clinical, 2026-04-11)
  • monitoring: Monitor blood glucose and ketones, hydration status, appetite, and clinical response at regular intervals. (Clinical, 2026-04-10)
  • monitoring: Monitor blood glucose and ketones, hydration status, appetite, and clinical response at regular intervals. (Clinical, 2026-04-10)
Recent Revisions
  • monitoring updated 2026-05-05 10:07 by curated_loader • FDA monitoring and urgent-action guidance for Senvelgo.
  • contraindications updated 2026-05-05 10:07 by curated_loader • FDA contraindication and warning summary for Senvelgo.
  • prescription_required updated 2026-05-05 10:07 by curated_loader • FDA original approval lists Senvelgo marketing status as Rx.
  • administration updated 2026-05-05 10:07 by curated_loader • FDA owner-facing guidance for giving Bexacat or Senvelgo.
  • strengths updated 2026-05-05 10:07 by curated_loader • FDA original approval lists Senvelgo concentration as 15 mg/mL.
  • dosage_forms updated 2026-05-05 10:07 by curated_loader • FDA original approval lists Senvelgo drug form as solution.
  • species updated 2026-05-05 10:07 by curated_loader • FDA original approval lists Senvelgo species as cats.
  • usage updated 2026-05-05 10:07 by curated_loader • FDA original approval indication for Senvelgo.
  • drug_profile_type updated 2026-05-05 10:07 by curated_loader • FDA source confirms Senvelgo as a branded approved product.
  • manufacturer_name updated 2026-05-05 10:07 by curated_loader • FDA warning letter identifies the approved sponsor/manufacturer.
  • brand_names updated 2026-05-05 10:07 by curated_loader • FDA warning letter references Senvelgo as the approved animal drug.
  • approval_reference updated 2026-05-05 10:07 by curated_loader • Official FDA application reference for Senvelgo.
  • monitoring updated 2026-05-03 10:07 by curated_loader • FDA monitoring and urgent-action guidance for Senvelgo.
  • contraindications updated 2026-05-03 10:07 by curated_loader • FDA contraindication and warning summary for Senvelgo.
  • prescription_required updated 2026-05-03 10:07 by curated_loader • FDA original approval lists Senvelgo marketing status as Rx.
  • administration updated 2026-05-03 10:07 by curated_loader • FDA owner-facing guidance for giving Bexacat or Senvelgo.
  • strengths updated 2026-05-03 10:07 by curated_loader • FDA original approval lists Senvelgo concentration as 15 mg/mL.
  • dosage_forms updated 2026-05-03 10:07 by curated_loader • FDA original approval lists Senvelgo drug form as solution.
  • species updated 2026-05-03 10:07 by curated_loader • FDA original approval lists Senvelgo species as cats.
  • usage updated 2026-05-03 10:07 by curated_loader • FDA original approval indication for Senvelgo.

FDA Products & Applications (Animal Drugs @ FDA)

Official sponsor/proprietary-name/application-status records linked by active ingredient.

Product Sponsor Application Status Published

Data source: FDA Animal Drugs @ FDA (public search export).

Top Reported Reactions (openFDA)

De-duplicated reaction terms grouped by body system from FDA openFDA reports (not verified; does not prove causation).

Digestive
Drooling (1) • Cat Diarrhea (1) • Cat Bloody diarrhoea (1) • Cat

Showing top 5 for Digestive.

Behavior
Behavioral disorder (1) • Cat

Showing top 5 for Behavior.

Effectiveness
Lack of efficacy - NOS (1) • Cat Lack of efficacy (ectoparasite) - flea (1) • Cat

Showing top 5 for Effectiveness.

Other
Ketosis (1) • Cat Ketonuria (1) • Cat Increased weight (1) • Cat Increased urine concentration (1) • Cat Inappropriate urination (1) • Dog
Show more (21)
Hypotension (1) • Cat Hypokalaemia (1) • Cat Hypoglycaemia (1) • Cat Hyperglycaemia (1) • Cat Haematuria (1) • Cat Haematemesis (1) • Cat Glucosuria (1) • Cat Frequent urination (1) • Dog Foaming at the mouth (1) • Cat Fever (1) • Cat Eosinopenia (1) • Cat Elevated fructosamine (1) • Cat Elevated betahydroxybutyrate (1) • Cat Diabetic ketoacidosis (1) • Cat Decreased percentage of reticulocytes (1) • Cat Decreased activity (1) • Cat Death by euthanasia (1) • Cat Cough (1) • Cat Chronic kidney disease (1) • Cat Blood in urine (1) • Dog Anaemia NOS (1) • Cat

Showing top 5 for Other.

Data source: FDA openFDA Animal & Veterinary adverse event reports.

Adverse Event Case Summaries (openFDA)

These are individual FDA adverse event reports. They are unverified and do not prove the medication caused the reaction.

Cat, Maine Coon, Female, 11 week, 5.035 kilogram • Drug: MSK, Solution, Oral, Dose: 0.40 mL per animal • Reactions: Not eating, Tiredness (lethargy), Fever, Decreased percentage of reticulocytes, Leucocytosis NOS… • Outcome: Recovered/Normal

  • Report ID: USA-USFDACVM-2025-US-075502
  • Serious AE: No
  • Treated For AE: No
  • Sex: Female
  • Age: 11.00 Week
  • Weight: 5.035 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Oral
  • Form: Solution
  • Dose: 0.40 mL per animal
Reactions Reported:
Not eating Tiredness (lethargy) Fever Decreased percentage of reticulocytes Leucocytosis NOS Eosinopenia Neutropenia Monocytosis
Outcomes: Recovered/Normal

Cat, Maine Coon, Male, 8 year, 9.117 kilogram • Drug: MSK, Solution, Oral, Dose: 0.99 Milligram per kilogram, Frequency: 1 per day • Reactions: Diarrhea, Bloody diarrhoea, Polyuria, Polydipsia • Outcome: Ongoing

  • Report ID: USA-USFDACVM-2025-US-075501
  • Serious AE: No
  • Treated For AE: Yes
  • Sex: Male
  • Age: 8.00 Year
  • Weight: 9.117 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Oral
  • Form: Solution
  • Dose: 0.99 Milligram per kilogram
  • Frequency: 1 per day
Reactions Reported:
Diarrhea Bloody diarrhoea Polyuria Polydipsia
Outcomes: Ongoing

Cat, Siamese, Male, 7 year, 6.759 kilogram • Drug: MSK, Solution, Oral, Frequency: 1 per day • Reactions: Soft stool, Hypoglycaemia • Outcome: Outcome Unknown

  • Report ID: USA-USFDACVM-2025-US-075104
  • Serious AE: No
  • Treated For AE: No
  • Sex: Male
  • Age: 7.00 Year
  • Weight: 6.759 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Oral
  • Form: Solution
  • Frequency: 1 per day
Reactions Reported:
Soft stool Hypoglycaemia
Outcomes: Outcome Unknown

Cat, Domestic Longhair, Male, 12 year, 3.629 kilogram • Drug: MSK, Solution, Oral • Reactions: Ketosis • Outcome: Ongoing

  • Report ID: USA-USFDACVM-2025-US-075099
  • Serious AE: No
  • Treated For AE: No
  • Sex: Male
  • Age: 12.00 Year
  • Weight: 3.629 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Oral
  • Form: Solution
Reactions Reported:
Ketosis
Outcomes: Ongoing

Cat, Domestic Shorthair, Male, 11 year, 5.398 kilogram • Drug: MSK, Solution, Oral • Reactions: Polyphagia, Ketosis • Outcome: Outcome Unknown

  • Report ID: USA-USFDACVM-2025-US-075092
  • Serious AE: No
  • Treated For AE: No
  • Sex: Male
  • Age: 11.00 Year
  • Weight: 5.398 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Oral
  • Form: Solution
Reactions Reported:
Polyphagia Ketosis
Outcomes: Outcome Unknown

Cat, Domestic Shorthair, Male, 8 year, 6.35 kilogram • Drug: MSK, Solution, Oral, Dose: 1 Milligram per kilogram, Frequency: 1 per day • Reactions: Diarrhea • Outcome: Outcome Unknown

  • Report ID: USA-USFDACVM-2025-US-074759
  • Serious AE: No
  • Treated For AE: Yes
  • Sex: Male
  • Age: 8.00 Year
  • Weight: 6.350 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Oral
  • Form: Solution
  • Dose: 1 Milligram per kilogram
  • Frequency: 1 per day
Reactions Reported:
Diarrhea
Outcomes: Outcome Unknown

Cat, Domestic Shorthair, Male, 6 year, 4.6 kilogram • Drug: MSK, Solution, Oral, Dose: 1 Milligram per kilogram, Frequency: 24 per hour • Reactions: Diarrhea • Outcome: Outcome Unknown

  • Report ID: USA-USFDACVM-2025-US-074006
  • Serious AE: No
  • Treated For AE: No
  • Sex: Male
  • Age: 6.00 Year
  • Weight: 4.600 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Oral
  • Form: Solution
  • Dose: 1 Milligram per kilogram
  • Frequency: 24 per hour
Reactions Reported:
Diarrhea
Outcomes: Outcome Unknown

Cat, Domestic Shorthair, Male, 12 year, 4.767 kilogram • Drug: MSK, Solution, Oral, Dose: 0.99 Milligram per kilogram • Reactions: Ketosis, Diabetic ketoacidosis • Outcome: Outcome Unknown

  • Report ID: USA-USFDACVM-2025-US-073997
  • Serious AE: Yes
  • Treated For AE: Yes
  • Sex: Male
  • Age: 12.00 Year
  • Weight: 4.767 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Oral
  • Form: Solution
  • Dose: 0.99 Milligram per kilogram
Reactions Reported:
Ketosis Diabetic ketoacidosis
Outcomes: Outcome Unknown

Data source: FDA openFDA Animal & Veterinary adverse event reports.

Overdose Information

No approved overdose-management text is linked yet. If overdose is suspected, contact a veterinarian or emergency clinic immediately.

Storage & Handling

No approved storage guidance is linked yet for this ingredient. Use manufacturer packaging and veterinary guidance for handling/storage.

Share Your Thoughts

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This medication has not been reviewed by a veterinarian yet.