Roxee Meds Catalog
Doxycycline
Medication catalog facts with explicit FDA-approval, off-label, source-limited, and safety context.
Veterinary professional?
Data freshness
Roxee has a partial storefront projection for this medication. Some primary facts still need verification.
Sponsor, product, and application records imported from Animal Drugs @ FDA.
openFDA reaction terms and case summaries are supporting evidence, not proof of causality.
Source timing details
-
Storefront facts:
Source Roxee
| Refreshed May 5, 2026, 10:05 AM UTC
The storefront fact projection used for browse cards and quick facts.
-
Animal Drug Product Listing Directory (NDC):
Source FDA
| Refreshed May 5, 2026, 10:00 AM UTC
Package/product NDCs from FDA’s electronic listing directory (XLS).
- openFDA reaction terms: Source FDA openFDA | Refreshed May 5, 2026, 10:04 AM UTC
- openFDA case summaries: Source FDA openFDA | Refreshed May 5, 2026, 10:04 AM UTC
Evidence
Reviewed / Updated / Sources
Reviewed by: Not available
Last reviewed: April 15, 2026
Updated: April 15, 2026, 10:04 AM UTC
- Medication contraindications · safety_warning
- openFDA case USA-USFDACVM-2025-US-070810 · adverse_reaction
- Structured Product Label · document
- Structured Product Label · document
- FOI summary · document
Doxycycline
Drug type: Generic ingredient • Branded profile • Not FDA-approved for animals
Species: Both
Approval status: Not FDA-approved as an animal drug. No FDA-approved animal-drug application is linked for this record. It may represent extra-label, human-drug, bulk-compounding, export-only, or otherwise unapproved animal-use source data; use only under veterinarian direction.
Medication Snapshot
Merged from the current Roxee medication system with field-level provenance, freshness, and completeness tracking.
Doxycycline
Tetracycline antibiotic used for a variety of infections (often tick-borne diseases in dogs). Species commonly shown: Both.
Indications / Uses
Tetracycline antibiotic used for a variety of infections (often tick-borne diseases in dogs).
Administration / How To Give
Oral
Storage
Store at room temperature; protect from moisture.
Warnings / Contraindications
Use caution in young animals and in pregnancy. In cats, dry pilling can cause esophageal injury.
- Use caution in young animals and in pregnancy. In cats, dry pilling can cause esophageal injury.
Side Effects
GI upset; photosensitivity.
FAQ
Related Medications
Source Transparency
- Verified source: https://www.roxee.ai/meds/
- Verified source: https://animaldrugsatfda.fda.gov
- Verified source: https://animaldrugsatfda.fda.gov/adafda/views/#/search
- Verified source: https://api.fda.gov/animalandveterinary/event.json
- Verified source: https://www.accessdata.fda.gov/spl/data/f6dbe65d-d131-4eb5-8ab1-75587d6dd241/f6dbe65d-d131-4eb5-8ab1-75587d6dd241.xml
- Verified source: https://www.accessdata.fda.gov/spl/data/2d9c5b43-423f-4ce5-949c-d534352584e7/2d9c5b43-423f-4ce5-949c-d534352584e7.xml
- Last refreshed: May 5, 2026, 10:05 a.m.
- Last verified: Apr 15, 2026, 10:04 a.m.
- Validation status: Incomplete
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Sign in to continuePet Owner Quick Guide
Start here first for the safest next-step summary before the deeper medication detail.
Used for:
Tetracycline antibiotic used for a variety of infections (often tick-borne diseases in dogs).
Dosing note:
Exact dosing depends on your pet's species, weight, and health status. Use your veterinarian's instructions for the exact dose and schedule.
What to watch for:
- Use caution in young animals and in pregnancy
- In cats, dry pilling can cause esophageal injury
- trouble breathing (1 reports)
- Loss of appetite (1 reports)
- Elevated gamma-glutamyl transferase (1 reports)
When to call the vet:
- Repeated vomiting or diarrhea.
- Severe lethargy (hard to wake, very low energy).
- Collapse or fainting.
- Facial swelling or hives.
- Blood in vomit or stool.
What to tell or ask your vet today:
- Is this medicine the right fit for my pet’s current symptoms?
- Which warning signs mean I should call back right away?
- How should I handle missed doses or refusal to take the medicine?
Major cautions & emergency warning signs
Side effects to monitor:
- Use caution in young animals and in pregnancy
- In cats, dry pilling can cause esophageal injury
- trouble breathing
- Loss of appetite
- Elevated gamma-glutamyl transferase
Most reported reactions:
- Trouble breathing (dyspnea) (1 reports)
- Loss of appetite (1 reports)
- Elevated gamma-glutamyl transferase (1 reports)
Emergency warning signs:
- Repeated vomiting or diarrhea.
- Severe lethargy (hard to wake, very low energy).
- Collapse or fainting.
- Facial swelling or hives.
Quick Facts
Official label facts first, then secondary summaries. Marketing content is separated below.
Warnings / Contraindications
Use caution in young animals and in pregnancy. In cats, dry pilling can cause esophageal injury.
- High: Use caution in young animals and in pregnancy. In cats, dry pilling can cause esophageal injury.
- https://animaldrugsatfda.fda.gov · safety_warning · Medication contraindications
Adverse Reactions
Snapshot first, detailed rows second. This section summarizes signal data and is not a diagnosis.
Tap or hover a reaction to see what it means in plain language.
Grouped by Body System
Most Reported Reactions
| Reaction | Body system | Cases | Species | Serious cases |
|---|---|---|---|---|
| Other | 1 | Dog | 1 | |
| Digestive | 1 | Dog | 1 | |
| Other | 1 | Dog | 1 | |
| Other | 1 | Dog | 1 | |
| Other | 1 | Dog | 1 | |
| Other | 1 | Dog | 1 | |
| Other | 1 | Dog | 1 | |
| Other | 1 | Dog | 1 |
Species coverage: Dog (20) Cat (12)
View detailed reaction table
| Reaction | Body system | Species | Seriousness | Frequency | Reports |
|---|---|---|---|---|---|
| Neurologic | Cat | Non-serious | - | 1 | |
| Other | Dog | Serious | - | 1 | |
| Digestive | Dog | Serious | - | 1 | |
| Other | Dog | Serious | - | 1 | |
| Other | Dog | Serious | - | 1 | |
| Other | Dog | Serious | - | 1 | |
| Other | Dog | Serious | - | 1 | |
| Other | Dog | Serious | - | 1 | |
| Other | Dog | Serious | - | 1 | |
| Other | Dog | Serious | - | 1 | |
| Other | Cat | Non-serious | - | 1 | |
| Other | Dog | Serious | - | 1 | |
| Digestive | Cat | Non-serious | - | 1 | |
| Other | Cat | Serious | - | 1 | |
| Other | Dog | Serious | - | 1 | |
| Other | Dog | Serious | - | 1 | |
| Other | Dog | Serious | - | 1 | |
| Other | Dog | Serious | - | 1 | |
| Other | Dog | Non-serious | - | 1 | |
| Digestive | Cat | Serious | - | 1 | |
| Other | Cat | Non-serious | - | 1 | |
| Other | Cat | Non-serious | - | 1 | |
| Other | Cat | Non-serious | - | 1 | |
| Other | Dog | Serious | - | 1 | |
| Other | Cat | Non-serious | - | 1 | |
| Skin & allergy | Cat | Non-serious | - | 1 | |
| Other | Dog | Serious | - | 1 | |
| Other | Cat | Serious | - | 1 | |
| Other | Dog | Serious | - | 1 | |
| Other | Dog | Serious | - | 1 | |
| Other | Cat | Serious | - | 1 | |
| Other | Dog | Serious | - | 1 |
- https://api.fda.gov/animalandveterinary/event.json · adverse_reaction · openFDA case USA-USFDACVM-2025-US-070810
Storage & Handling
Store at room temperature; protect from moisture.
Documents
Owner handouts and official technical documents open on-page first, with the original source still one click away.
Owner handouts
0Official label / PI
0SPL
2FOI
1AX Pharmaceutical Corp SPL
SPL · Structured Product Label
Doxycycline Monohydrate SPL
SPL · Structured Product Label
UCM437264.pdf
FOI · FOI summary
- https://www.accessdata.fda.gov/spl/data/2d9c5b43-423f-4ce5-949c-d534352584e7/2d9c5b43-423f-4ce5-949c-d534352584e7.xml · document · Structured Product Label
- https://www.accessdata.fda.gov/spl/data/f6dbe65d-d131-4eb5-8ab1-75587d6dd241/f6dbe65d-d131-4eb5-8ab1-75587d6dd241.xml · document · Structured Product Label
- https://animaldrugsatfda.fda.gov/adafda/app/search/public/document/downloadFoi/616 · document · FOI summary
Veterinary reference (advanced)
Canonical medication sections are above. This legacy block remains available for deeper cross-reference without cluttering the primary workflow.
At a Glance
Quick facts and links to official labeling and safety signals.
-
Storefront facts:
Source Roxee
| Refreshed May 5, 2026, 10:05 AM UTC
The storefront fact projection used for browse cards and quick facts.
-
Animal Drug Product Listing Directory (NDC):
Source FDA
| Refreshed May 5, 2026, 10:00 AM UTC
Package/product NDCs from FDA’s electronic listing directory (XLS).
- openFDA reaction terms: Source FDA openFDA | Refreshed May 5, 2026, 10:04 AM UTC
- openFDA case summaries: Source FDA openFDA | Refreshed May 5, 2026, 10:04 AM UTC
Counseling and Monitoring Highlights
Global Pet owner/Vet mode is controlled in the header. This section avoids duplicate in-page persona tabs.
- Use caution in young animals and in pregnancy. In cats, dry pilling can cause esophageal injury. (Contraindication, High)
Identifiers & Packages
Normalized identifiers (NDC/NADA/ANADA) and package metadata from regulator listings.
| Package NDC | Product NDC | Form / Route | Status |
|---|---|---|---|
| 17163-017-16 | 17163 | - | |
| 43457-541-25 | 43457 | - | |
| 46144-604-01 | 46144 | - | |
| 54771-5193-1 | 54771 | - | |
| 58645-005-01 | 58645 | - | |
| 62157-482-01 | 62157 | - | |
| 62157-538-01 | 62157 | - | |
| 62157-816-01 | 62157 | - | |
| 73377-033-01 | 73377 | - | |
| 73377-033-02 | 73377 | - | |
| 73377-033-03 | 73377 | - |
Enriched Documents
Documents are tiered by source trust: Official, Clinical, Manufacturer, Marketing.
-
AX Pharmaceutical Corp SPL
• Structured Product Label • Official
FDA Structured Product Label from the electronic animal drug product listing directory.
-
Doxycycline Monohydrate SPL
• Structured Product Label • Official
FDA Structured Product Label from the electronic animal drug product listing directory.
-
UCM437264.pdf
• FOI summary • Official
• June 1, 2016
FDA FOI summary for application 141082
Data Sources & Change Log
Every non-trivial field is expected to include provenance and update timestamps.
- contraindications: Use caution in young animals and in pregnancy. In cats, dry pilling can cause esophageal injury. (Clinical, 2026-05-05)
- contraindications: Use caution in young animals and in pregnancy. In cats, dry pilling can cause esophageal injury. (Clinical, 2026-05-03)
- contraindications: Use caution in young animals and in pregnancy. In cats, dry pilling can cause esophageal injury. (Clinical, 2026-05-02)
- contraindications: Use caution in young animals and in pregnancy. In cats, dry pilling can cause esophageal injury. (Clinical, 2026-04-29)
- contraindications: Use caution in young animals and in pregnancy. In cats, dry pilling can cause esophageal injury. (Clinical, 2026-04-28)
- contraindications: Use caution in young animals and in pregnancy. In cats, dry pilling can cause esophageal injury. (Clinical, 2026-04-27)
- contraindications: Use caution in young animals and in pregnancy. In cats, dry pilling can cause esophageal injury. (Clinical, 2026-04-26)
- contraindications: Use caution in young animals and in pregnancy. In cats, dry pilling can cause esophageal injury. (Clinical, 2026-04-25)
- contraindications: Use caution in young animals and in pregnancy. In cats, dry pilling can cause esophageal injury. (Clinical, 2026-04-17)
- contraindications: Use caution in young animals and in pregnancy. In cats, dry pilling can cause esophageal injury. (Clinical, 2026-04-15)
- contraindications: Use caution in young animals and in pregnancy. In cats, dry pilling can cause esophageal injury. (Clinical, 2026-04-15)
- contraindications: Use caution in young animals and in pregnancy. In cats, dry pilling can cause esophageal injury. (Clinical, 2026-04-11)
- monitoring: Monitor blood glucose and ketones, hydration status, appetite, and clinical response at regular intervals. (Clinical, 2026-04-21)
- monitoring: Monitor blood glucose and ketones, hydration status, appetite, and clinical response at regular intervals. (Clinical, 2026-04-20)
- monitoring: Monitor blood glucose and ketones, hydration status, appetite, and clinical response at regular intervals. (Clinical, 2026-04-19)
- monitoring: Monitor blood glucose and ketones, hydration status, appetite, and clinical response at regular intervals. (Clinical, 2026-04-17)
- monitoring: Monitor blood glucose and ketones, hydration status, appetite, and clinical response at regular intervals. (Clinical, 2026-04-16)
- monitoring: Monitor blood glucose and ketones, hydration status, appetite, and clinical response at regular intervals. (Clinical, 2026-04-16)
- monitoring: Monitor blood glucose and ketones, hydration status, appetite, and clinical response at regular intervals. (Clinical, 2026-04-15)
- side_effects: GI upset; photosensitivity. (Clinical, 2026-04-11)
- side_effects updated 2026-05-05 10:05 by etl_backfill • Backfilled from existing medication fields
- contraindications updated 2026-05-05 10:05 by etl_backfill • Backfilled from existing medication fields
- usage updated 2026-05-05 10:05 by etl_backfill • Backfilled from existing medication fields
- side_effects updated 2026-05-03 10:05 by etl_backfill • Backfilled from existing medication fields
- contraindications updated 2026-05-03 10:05 by etl_backfill • Backfilled from existing medication fields
- usage updated 2026-05-03 10:05 by etl_backfill • Backfilled from existing medication fields
- side_effects updated 2026-05-02 10:05 by etl_backfill • Backfilled from existing medication fields
- contraindications updated 2026-05-02 10:05 by etl_backfill • Backfilled from existing medication fields
- usage updated 2026-05-02 10:05 by etl_backfill • Backfilled from existing medication fields
- side_effects updated 2026-04-30 10:09 by etl_backfill • Backfilled from existing medication fields
- contraindications updated 2026-04-30 10:09 by etl_backfill • Backfilled from existing medication fields
- usage updated 2026-04-30 10:09 by etl_backfill • Backfilled from existing medication fields
- side_effects updated 2026-04-29 10:05 by etl_backfill • Backfilled from existing medication fields
- contraindications updated 2026-04-29 10:05 by etl_backfill • Backfilled from existing medication fields
- usage updated 2026-04-29 10:05 by etl_backfill • Backfilled from existing medication fields
- side_effects updated 2026-04-28 10:05 by etl_backfill • Backfilled from existing medication fields
- contraindications updated 2026-04-28 10:05 by etl_backfill • Backfilled from existing medication fields
- usage updated 2026-04-28 10:05 by etl_backfill • Backfilled from existing medication fields
- side_effects updated 2026-04-27 10:05 by etl_backfill • Backfilled from existing medication fields
- contraindications updated 2026-04-27 10:05 by etl_backfill • Backfilled from existing medication fields
FDA Products & Applications (Animal Drugs @ FDA)
Official sponsor/proprietary-name/application-status records linked by active ingredient.
| Product | Sponsor | Application | Status | Published |
|---|
Data source: FDA Animal Drugs @ FDA (public search export).
Usage
Tetracycline antibiotic used for a variety of infections (often tick-borne diseases in dogs).
Contraindications
Use caution in young animals and in pregnancy. In cats, dry pilling can cause esophageal injury.
Side Effects
GI upset; photosensitivity.
Source: FDA openFDA • Reference
Top Reported Reactions (openFDA)
De-duplicated reaction terms grouped by body system from FDA openFDA reports (not verified; does not prove causation).
Showing top 5 for Digestive.
Showing top 5 for Skin & allergy.
Showing top 5 for Neurologic.
Show more (22)
Showing top 5 for Other.
Data source: FDA openFDA Animal & Veterinary adverse event reports.
Adverse Event Case Summaries (openFDA)
These are individual FDA adverse event reports. They are unverified and do not prove the medication caused the reaction.
Cat, Domestic Shorthair, Male • Drug: MSK, Unassigned, Unknown • Reactions: Not eating, Balance impaired, Application site hair loss, Application site scab • Outcome: Recovered/Normal
- Report ID: USA-USFDACVM-2025-US-075299
- Serious AE: No
- Treated For AE: No
- Sex: Male
- Case-reported brand: MSK
- Case-reported manufacturer: MSK
- Route: Unknown
- Form: Unassigned
Dog, ['Terrier - Jack Russell', 'Dog (unknown)'], Female, 3.5 year, 8.437 kilogram • Drug: MSK, Unassigned, Unknown • Reactions: Lack of efficacy (endoparasite) - heartworm • Outcome: Ongoing
- Report ID: USA-USFDACVM-2025-US-075154
- Serious AE: Yes
- Treated For AE: No
- Sex: Female
- Age: 3.50 Year
- Weight: 8.437 Kilogram
- Case-reported brand: MSK
- Case-reported manufacturer: MSK
- Route: Unknown
- Form: Unassigned
Dog, Pit Bull, Male, 9 year, 40.82 kilogram • Drug: MSK, Unknown • Reactions: Lack of efficacy (endoparasite) - heartworm • Outcome: Outcome Unknown
- Report ID: USA-USFDACVM-2025-US-074999
- Serious AE: No
- Treated For AE: Yes
- Sex: Male
- Age: 9.00 Year
- Weight: 40.820 Kilogram
- Case-reported brand: MSK
- Case-reported manufacturer: MSK
- Route: Unknown
Dog, Pit Bull, Female, 6 year, 40.824 kilogram • Drug: MSK, Unknown • Reactions: Lack of efficacy (endoparasite) - heartworm • Outcome: Outcome Unknown
- Report ID: USA-USFDACVM-2025-US-074812
- Serious AE: No
- Treated For AE: Yes
- Sex: Female
- Age: 6.00 Year
- Weight: 40.824 Kilogram
- Case-reported brand: MSK
- Case-reported manufacturer: MSK
- Route: Unknown
Dog, Terrier - Jack Russell, Male, 1.5 year, 6.8 kilogram • Drug: MSK, Oral • Reactions: Lack of efficacy (endoparasite) - heartworm • Outcome: Outcome Unknown
- Report ID: USA-USFDACVM-2025-US-074826
- Serious AE: No
- Treated For AE: No
- Sex: Male
- Age: 1.50 Year
- Weight: 6.800 Kilogram
- Case-reported brand: MSK
- Case-reported manufacturer: MSK
- Route: Oral
Dog, Pointing Dog - German Short-haired, Female, 7 year, 30.028 kilogram • Drug: MSK, Unassigned, Oral • Reactions: Elevated serum alkaline phosphatase, Elevated aspartate aminotransferase • Outcome: Ongoing
- Report ID: USA-USFDACVM-2025-US-074396
- Serious AE: Yes
- Treated For AE: Yes
- Sex: Female
- Age: 7.00 Year
- Weight: 30.028 Kilogram
- Case-reported brand: MSK
- Case-reported manufacturer: MSK
- Route: Oral
- Form: Unassigned
Dog, ['Chihuahua', 'Dog (unknown)'], Female, 20 week, 2.26 kilogram • Drug: MSK, Unknown • Reactions: Icterus, Death, Other abnormal test result NOS, Elevated liver enzymes NOS, Swollen joint… • Outcome: Died
- Report ID: USA-USFDACVM-2025-US-074897
- Serious AE: Yes
- Treated For AE: Yes
- Sex: Female
- Age: 20.00 Week
- Weight: 2.260 Kilogram
- Case-reported brand: MSK
- Case-reported manufacturer: MSK
- Route: Unknown
Dog, Terrier - Jack Russell, Male, 3 year, 5.897 kilogram • Drug: MSK, Tablet, Oral, Dose: 0.50 tablet per animal • Reactions: Lack of efficacy - NOS, Intentional misuse, Not eating, Not drinking • Outcome: Ongoing
- Report ID: USA-USFDACVM-2025-US-074246
- Serious AE: Yes
- Treated For AE: Yes
- Sex: Male
- Age: 3.00 Year
- Weight: 5.897 Kilogram
- Case-reported brand: MSK
- Case-reported manufacturer: MSK
- Route: Oral
- Form: Tablet
- Dose: 0.50 tablet per animal
Data source: FDA openFDA Animal & Veterinary adverse event reports.
Overdose Information
No approved overdose-management text is linked yet. If overdose is suspected, contact a veterinarian or emergency clinic immediately.
Storage & Handling
Store at room temperature; protect from moisture.
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