Medication reference facts with explicit FDA-approval, off-label, source-limited, and safety context. Roxee does not sell, prescribe, or dispense medications.
BothReference completeFDA data linkedRx requiredLiquid (Solution)Multiple FDA sponsors
Official label facts
Owner quick guide first
Merged from the current Roxee medication system with field-level provenance, freshness, and completeness tracking.
Butorphanol
For the relief of chronic nonproductive cough associated with tracheo-bronchitis, tracheitis tonsillitis, laryngitis, and pharyngitis associated with inflammatory conditions of the upper respiratory tract. For the relief of pain associated with colic and postpartum pain in adult horses and yearlings. For the relief of pain in cats caused by major or minor trauma, or pain associated with surgical procedures. Species commonly shown: Both, Cat, Horse, Not For Meat Production.
For the relief of chronic nonproductive cough associated with tracheo-bronchitis, tracheitis tonsillitis, laryngitis, and pharyngitis associated with inflammatory conditions of the upper respiratory tract. For the relief of pain associated with colic and postpartum pain in adult horses and yearlings. For the relief of pain in cats caused by major or minor trauma, or pain associated with surgical procedures.
Warnings / Contraindications
Repeat at intervals of 6 to 12 hours as required. If necessary, increase dose to maximum of 0.05 milligram per pound of body weight. Treatment should not normally be required for longer than 7 days. Federal law restricts this drug to use by or on the order of a licensed veterinarian. For oral use in dogs only. Repeat at intervals of 6 to 12 hours as required. If necessary, increase dose to a maximum of 0.5 milligram per pound of body weight. Treatment should not normally be required for longer than 7 days. Federal law restricts this drug to use by or on the order of a licensed veterinarian. Dose may be repeated within 3 to 4 hours. Treatment should not exceed 48 hours. Not for use in horses intended for food. Federal law restricts this drug to use by or on the order of a licensed veterinarian.
Repeat at intervals of 6 to 12 hours as required. If necessary, increase dose to maximum of 0.05 milligram per pound of body weight. Treatment should not normally be required for longer than 7 days. Federal law restricts this drug to use by or on the order of a licensed veterinarian. For oral use in dogs only. Repeat at intervals of 6 to 12 hours as required. If necessary, increase dose to a maximum of 0.5 milligram per pound of body weight. Treatment should not normally be required for longer than 7 days. Federal law restricts this drug to use by or on the order of a licensed veterinarian. Dose may be repeated within 3 to 4 hours. Treatment should not exceed 48 hours. Not for use in horses intended for food. Federal law restricts this drug to use by or on the order of a licensed veterinarian.
Side Effects
Top reported reactions (openFDA): Lack of efficacy - NOS, Vomiting, Death, Diarrhoea, Bradycardia, Lethargy (see also Central nervous system depression in 'Neurological').
A source-aware map of what to know, what is uncertain, and what to verify with your veterinarian.
Source Backed Signals
What to know
Evidence-backed contextLimited
Roxee has limited cited overview evidence for Butorphanol; use the official documents and your veterinarian's instructions for product-specific decisions.
Source: openFDA case USA-USFDACVM-2025-US-070810
Safety signal coverageReported signals
32 tracked reaction signals; 32 reported cases; 20 serious reports; 2 species groups. These are reporting and label-derived signals for interpretation with a veterinarian.
Source: openFDA case USA-USFDACVM-2025-US-070810
Interpretation guardrailNot causation
Adverse-event reports help form a watch list, but they do not prove the medication caused the reaction and they are not a risk ranking between medications.
Evidence tension
Stronger signalLabel / review
Official labels, package inserts, and reviewed summaries carry more weight than isolated reports.
Source: openFDA case USA-USFDACVM-2025-US-070810
Weaker signalReported data
Case reports and openFDA terms are useful for pattern awareness, but they are incomplete, can include multiple exposures, and do not estimate an individual pet's probability of harm.
Domestic Shorthair (3), Pug (1), Ragdoll (1), Terrier - Bull - Staffordshire (1). These are report metadata, not proof that a breed is at higher risk.
What your vet may verify
Fit for this patientVet check
Verify whether Butorphanol fits the pet's species, current diagnosis, age, weight, organ status, pregnancy/lactation status, and concurrent medications.
Evidence limitationsEvidence review
Separate label-backed warnings from adverse-event reports and owner observations before changing the plan.
What to watch next
Watch listOwner-safe
Repeat at intervals of 6 to 12 hours as required, If necessary, increase dose to maximum of 0.05 milligram per pound of body weight, Treatment should not normally be required for longer than 7 days, For oral use in dogs only, If necessary, increase dose to a maximum of 0.5 milligram per pound of body weight
Call sooner ifEscalation
Repeated vomiting or diarrhea. Severe lethargy (hard to wake, very low energy). Collapse or fainting.
Bottom line: Use this Butorphanol brief as a structured watch list and source map, not as a reason to start, stop, or change treatment without your veterinarian.
Repeat at intervals of 6 to 12 hours as required. If necessary, increase dose to maximum of 0.05 milligram per pound of body weight. Treatment should not normally be required for longer than 7 days. Federal law restricts this drug to use by or on the order of a licensed veterinarian. For oral use in dogs only. Repeat at intervals of 6 to 12 hours as required. If necessary, increase dose to a maximum of 0.5 milligram per pound of body weight. Treatment should not normally be required for longer than 7 days. Federal law restricts this drug to use by or on the order of a licensed veterinarian. Dose may be repeated within 3 to 4 hours. Treatment should not exceed 48 hours. Not for use in horses intended for food. Federal law restricts this drug to use by or on the order of a licensed veterinarian.
High: Repeat at intervals of 6 to 12 hours as required. If necessary, increase dose to maximum of 0.05 milligram per pound of body weight. Treatment should not normally be required for longer than 7 days. Federal law restricts this drug to use by or on the order of a licensed veterinarian. For oral use in dogs only. Repeat at intervals of 6 to 12 hours as required. If necessary, increase dose to a maximum of 0.5 milligram per pound of body weight. Treatment should not normally be required for longer than 7 days. Federal law restricts this drug to use by or on the order of a licensed veterinarian. Dose may be repeated within 3 to 4 hours. Treatment should not exceed 48 hours. Not for use in horses intended for food. Federal law restricts this drug to use by or on the order of a licensed veterinarian.
Facial swelling (see also Skin)Hypersensitivity reactionEmesis (multiple)Bloody diarrhoeaAtaxiaElevated total bilirubinElevated alanine aminotransferase (ALT)Elevated blood urea nitrogen (BUN)Lethargy (see also Central nervous system depression in Neurological)Intentional misuse
Body systems
Skin & allergyOtherDigestiveNeurologic
Outcomes
Ongoing
USA-USFDACVM-2026-US-013633
Received 2026-03-19
· MSK
· MSK
Non-serious
Species
Cat
Breed
Domestic Shorthair
Size / weight
10-24 lb (5.33 Kilogram)
Age
8+ years (11 Year)
Sex
Female Neutered
Region
USA
Reactions
DysphoriaBehavioural disorder NOSDilated pupilsAnorexiaSkin and tissue infection NOSLethargy (see also Central nervous system depression in Neurological)
Body systems
OtherBehaviorDigestiveNeurologic
Outcomes
Recovered/Normal
USA-USFDACVM-2026-US-013265
Received 2026-03-16
· MSK
· MSK
Non-serious
Species
Dog
Breed
Corso Dog
Size / weight
50-99 lb (42.184 Kilogram)
Age
1-3 years (1 Year)
Sex
Female Neutered
Region
USA
Reactions
Lethargy (see also Central nervous system depression in Neurological)Not eatingFeverInjection site lumpApplication site serous discharge
Body systems
NeurologicOther
Outcomes
Ongoing
USA-USFDACVM-2026-US-011996
Received 2026-03-13
· MSK
· MSK
Serious
Species
Dog
Breed
Terrier - Bull - American Pit
Size / weight
50-99 lb (29.937 Kilogram)
Age
4-7 years (5 Year)
Sex
Male Neutered
Region
USA
Reactions
Injection site painAnorexiaFeverInjection site swellingInjection site abscessLethargy (see also Central nervous system depression in Neurological)
Body systems
OtherDigestiveSkin & allergyNeurologic
Outcomes
Ongoing
USA-USFDACVM-2026-US-008820
Received 2026-02-16
· MSK
· MSK
Serious
Species
Cat
Breed
Siamese
Size / weight
10-24 lb (4.763 Kilogram)
Age
1-3 years (1 Year)
Sex
Male Neutered
Region
USA
Reactions
AnaphylaxisVomitingBloody stoolLethargy (see also Central nervous system depression in Neurological)HypothermiaElevated alanine aminotransferase (ALT)Elevated blood urea nitrogen (BUN)HyperphosphataemiaLeukocytosis NOSElevated total bilirubin
Body systems
OtherDigestiveNeurologic
Outcomes
Ongoing
USA-USFDACVM-2026-US-003352
Received 2026-01-27
· MSK
· MSK
Serious
Species
Cat
Breed
Domestic Shorthair
Size / weight
Under 10 lb (3.992 Kilogram)
Age
8+ years (13 Year)
Sex
Female Neutered
Region
USA
Reactions
DiarrhoeaDecreased appetiteLethargy (see also Central nervous system depression in Neurological)Bloody diarrhoeaDry mucous membraneOpen mouth breathingUnresponsive to stimuliDecreased haematocritIncreased percentage reticulocytesRegenerative anaemiaIntentional misuseThrombocytopeniaHypersalivationHeart murmur
Body systems
DigestiveNeurologicOther
Outcomes
Ongoing
USA-USFDACVM-2026-US-002976
Received 2026-01-20
· MSK
· MSK
Serious
Species
Dog
Breed
Shih Tzu
Size / weight
Under 10 lb (2.449 Kilogram)
Age
Under 1 year (2 Month)
Sex
Male Intact
Region
USA
Reactions
Lethargy (see also Central nervous system depression in Neurological)VomitingBloody diarrhoeaDiarrhoeaReluctant to moveDecreased body temperaturePale mucous membraneHypoglycaemiaFluid in abdomen NOSFeverDistension of abdomenNeutropeniaLeukocytosis NOSDecreased haematocritNot eatingObtundedHypersalivationAbdominal discomfortDecreased skin turgorBreathing difficultyFlaccid musclesProlonged capillary refill timeRegurgitationLack of efficacy - NOSLymphopeniaMonocytosisLeukopenia NOSHyponatremiaHypercalcaemiaIncreased band neutrophiliaIleusAbnormal radiograph findingIntestinal thickeningHypokalaemiaNasal dischargeIncreased respiratory rateLymphocytosisAbnormal ultrasound findingLateral recumbencyWeak pulseIntentional misuse
Body systems
NeurologicDigestiveOtherEffectiveness
Outcomes
Ongoing
USA-USFDACVM-2026-US-003528
Received 2026-01-19
· MSK
· MSK
Serious
Species
Cat
Breed
Domestic Shorthair
Size / weight
Under 10 lb (4 Kilogram)
Age
8+ years (13 Year)
Sex
Female Neutered
Region
USA
Reactions
Unresponsive to stimuliOpen mouth breathingAnorexiaLethargy (see also Central nervous system depression in Neurological)DiarrhoeaDry mucous membraneBloody diarrhoeaIncreased percentage reticulocytesDecreased haematocritRegenerative anaemiaThrombocytopeniaHypersalivationMurmur
Body systems
OtherDigestiveNeurologic
Outcomes
Ongoing
USA-USFDACVM-2025-US-074194
Received 2025-12-19
· MSK
· MSK
Serious
Species
Dog
Breed
Bulldog - French
Size / weight
25-49 lb (12.428 Kilogram)
Age
8+ years (8 Year)
Sex
Male Neutered
Region
USA
Reactions
Decreased appetiteDecreased drinkingLethargy (see also Central nervous system depression in Neurological)PantingTense musclesSeizure NOSInappropriate defecationInappropriate urinationUnable to walkProprioception deficitGeneralised weaknessLamenessLimb non-weight bearingAbnormal radiograph findingMedication error NOS
Body systems
DigestiveOtherNeurologic
Outcomes
Recovered/Normal
USA-USFDACVM-2025-US-074994
Received 2025-12-17
· MSK
· MSK
Serious
Species
Cat
Breed
Maine Coon
Size / weight
10-24 lb (6.58 Kilogram)
Age
8+ years (13 Year)
Sex
Male Neutered
Region
USA
Reactions
TwitchingFocal seizureDeathLethargy (see also Central nervous system depression in Neurological)
Body systems
Skin & allergyNeurologicOther
Outcomes
Died
USA-USFDACVM-2025-US-074533
Received 2025-12-17
· MSK
· MSK
Serious
Species
Cat
Breed
Domestic Shorthair
Size / weight
Under 10 lb (2.5 Kilogram)
Age
Under 1 year (4 Month)
Sex
Female Neutered
Region
USA
Reactions
HypersalivationTachypnoeaAbnormal radiograph findingHypothermiaHyperactivityNot eatingLethargy (see also Central nervous system depression in Neurological)Hiding
Body systems
DigestiveOtherNeurologic
Outcomes
Ongoing
USA-USFDACVM-2025-US-067000
Received 2025-11-14
· MSK
· MSK
Serious
Species
Cat
Breed
Domestic Shorthair
Size / weight
Under 10 lb (3.992 Kilogram)
Age
8+ years (13 Year)
Sex
Female Unknown
Region
USA
Reactions
DiarrhoeaDecreased appetiteLethargy (see also Central nervous system depression in Neurological)Bloody diarrhoeaDry mucous membraneOpen mouth breathingUnresponsive to stimuliDecreased haematocritIncreased percentage reticulocytesRegenerative anaemiaIntentional misuseUnderdoseThrombocytopeniaHeart murmurHypersalivation
Body systems
DigestiveNeurologicOther
Outcomes
Ongoing
Tap or hover a reaction to see what it means in plain language.
Tracked signals
32
Reported cases
32
Serious reports
20
Species represented
2
Grouped by Body System
Digestive (1)
· Loss of appetite
Skin & allergy (4)
· Hair loss at application site, Application site hair loss, Alopecia local
Neurologic (1)
· Unsteady walking (ataxia)
Behavior (2)
· Behavioral disorder (unspecified), Anxiety
Other (24)
· Blood clot, Basophilia, Balance problem
Rendered from Roxee's cached FDA SPL package contents for on-page reading. Use Open original for the raw FDA ZIP/XML source.
Sponsor
Dechra Veterinary Products LLC
ANADA
200-408
Status
RX
Form
Liquid (Solution)
Route
Subcutaneous
Species
Cat
Composition / specifications
Each milliliter of aqueous solution contains 2 milligrams of butorphanol (as butorphanol tartrate).
Cats
Indication
For the relief of pain in cats caused by major or minor trauma, or pain associated with surgical procedures
Dosage
0.2 milligram of butorphanol base activity per pound of body weight (0.4 milligrams per kilogram), using 2 milligrams per milliliter solution. For subcutaneous injection.
Limitations
Dose may be repeated up to 4 times per day. Do not treat for more than 2 days. Safety for use in pregnant female cats, breeding male cats of kittens less than 4 months of age has not been determined. Federal law restricts this drug to use by or on the order of a licensed veterinarian
Rendered from Roxee's cached FDA SPL package contents for on-page reading. Use Open original for the raw FDA ZIP/XML source.
Sponsor
Cronus Pharma Specialities India Private Ltd.
ANADA
200-332
Status
RX
Form
Liquid (Solution)
Route
Intravenous
Composition / specifications
Each milliliter of aqueous solution contains 10 milligrams of butorphanol (as butorphanol tartrate).
Horses
Indication
For the relief of pain associated with colic and postpartum pain in adult horses and yearlings.
Dosage
0.05 milligram of butorphanol per pound of body weight (0.1 milligram per kilogram of body weight). Dose may be repeated within 3 to 4 hours. Treatment should not exceed 48 hours.
Limitations
Do not use in horses intended for human consumption. Federal law restricts this drug to use by or on the order of a licensed veterinarian.
Rendered from Roxee's cached FDA SPL package contents for on-page reading. Use Open original for the raw FDA ZIP/XML source.
Sponsor
Dechra Veterinary Products LLC
ANADA
200-322
Status
RX
Form
Liquid (Solution)
Route
Intravenous
Species
Horse
Composition / specifications
Each milliliter of aqueous solution contains 10 milligrams of butorphanol (as butorphanol tartrate).
Horses
Indication
For the relief of pain associated with colic and postpartum pain in adult horses and yearlings.
Dosage
0.05 milligram of butorphanol base activity per pound of body weight (0.1 milligram/kilogram) using 10 milligrams per milliliter solution. For intravenous use.
Limitations
Dose may be repeated within 3 to 4 hours. Treatment should not exceed 48 hours. Not for use in horses intended for food. Federal law restricts this drug to use by or on the order of a licensed veterinarian.
Rendered from Roxee's cached FDA SPL package contents for on-page reading. Use Open original for the raw FDA ZIP/XML source.
Sponsor
Intervet, Inc.
ANADA
200-239
Status
RX
Form
Liquid (Solution)
Route
Intravenous
Species
Horse
Composition / specifications
Each milliliter of aqueous solution contains 10 milligrams of butorphanol (as butorphanol tartrate).
Horses
Indication
For the relief of pain associated with colic and postpartum pain in adult horses and yearlings.
Dosage
0.05 milligram of butorphanol base activity per pound of body weight (0.1 milligram/kilogram) using 10 milligrams per milliliter solution. For intravenous use.
Limitations
Dose may be repeated within 3 to 4 hours. Treatment should not exceed 48 hours. Not for use in horses intended for food. Federal law restricts this drug to use by or on the order of a licensed veterinarian.
Rendered from Roxee's cached FDA SPL package contents for on-page reading. Use Open original for the raw FDA ZIP/XML source.
Sponsor
Zoetis Inc.
NADA
141-047
Status
RX
Form
Liquid (Solution)
Route
Subcutaneous
Species
Cat
Composition / specifications
Each milliliter of aqueous solution contains 2 milligrams of butorphanol (as butorphanol tartrate).
Cats
Indication
For the relief of pain in cats caused by major or minor trauma, or pain associated with surgical procedures.
Dosage
0.2 milligram of butorphanol base activity per pound of body weight (0.4 milligrams per kilogram)
Limitations
For subcutaneous injection. Dose may be repeated up to 4 times per day. Do not treat for more than 2 days. Safety for use in pregnant female cats, breeding male cats of kittens less than 4 months of age has not been determined. Federal law restricts this drug to use by or on the order of a licensed veterinarian.
Diagnosis-code mappings are not available for this medication yet.
Counseling and Monitoring Highlights
Global Pet owner/Vet mode is controlled in the header. This section avoids duplicate in-page persona tabs.
Owner-facing counseling points
Repeat at intervals of 6 to 12 hours as required. If necessary, increase dose to maximum of 0.05 milligram per pound of body weight. Treatment should not normally be required for longer than 7 days. Federal law restricts this drug to use by or on the order of a licensed veterinarian. For oral use in dogs only. Repeat at intervals of 6 to 12 hours as required. If necessary, increase dose to a maximum of 0.5 milligram per pound of body weight. Treatment should not normally be required for longer than 7 days. Federal law restricts this drug to use by or on the order of a licensed veterinarian. Dose may be repeated within 3 to 4 hours. Treatment should not exceed 48 hours. Not for use in horses intended for food. Federal law restricts this drug to use by or on the order of a licensed veterinarian. (Contraindication, High)
Top reaction signals
Unsteady walking (ataxia) (1)Behavioral disorder (unspecified) (1)Basophilia (1)Balance problem (1)Aspiration pneumonia (1)Application site pain (1)Application site dry skin (1)Apnoea (1)
Identifiers & Packages
Normalized identifiers (NDC/NADA/ANADA) and package metadata from regulator listings.
Documents are tiered by source trust: Official, Clinical, Manufacturer, Marketing.
ucm061350.pdf • FOI summary • Official • Feb. 27, 2026
FDA FOI summary for application 200408
ucm061797.pdf • FOI summary • Official • June 13, 2024
FDA FOI summary for application 200332
ucm061785.pdf • FOI summary • Official • Oct. 7, 2022
FDA FOI summary for application 200322
UCM214392.pdf • FOI summary • Official • April 26, 2022
FDA FOI summary for application 200446
UCM061667.pdf • FOI summary • Official • June 1, 2016
FDA FOI summary for application 200239
UCM490962.pdf • FOI summary • Official • June 1, 2016
FDA FOI summary for application 141047
Data Sources & Change Log
Every non-trivial field is expected to include provenance and update timestamps.
Official 117Clinical 9Manufacturer 0Marketing 0
Current Field Facts
contraindications: Repeat at intervals of 6 to 12 hours as required. If necessary, increase dose to maximum of 0.05 milligram per pound of body weight. Treatment should not norma… (Clinical, 2026-04-15)
contraindications: Repeat at intervals of 6 to 12 hours as required. If necessary, increase dose to maximum of 0.05 milligram per pound of body weight. Treatment should not norma… (Clinical, 2026-04-15)
contraindications: Repeat at intervals of 6 to 12 hours as required. If necessary, increase dose to maximum of 0.05 milligram per pound of body weight. Treatment should not norma… (Clinical, 2026-04-11)
monitoring: Monitor blood glucose and ketones, hydration status, appetite, and clinical response at regular intervals. (Clinical, 2026-04-16)
monitoring: Monitor blood glucose and ketones, hydration status, appetite, and clinical response at regular intervals. (Clinical, 2026-04-15)
side_effects: Top reported reactions (openFDA): Lack of efficacy - NOS, Vomiting, Death, Diarrhoea, Bradycardia, Lethargy (see also Central nervous system depression in 'Neu… (Clinical, 2026-04-11)
usage: For the relief of chronic nonproductive cough associated with tracheo-bronchitis, tracheitis tonsillitis, laryngitis, and pharyngitis associated with inflammat… (Clinical, 2026-04-15)
usage: For the relief of chronic nonproductive cough associated with tracheo-bronchitis, tracheitis tonsillitis, laryngitis, and pharyngitis associated with inflammat… (Clinical, 2026-04-15)
usage: For the relief of chronic nonproductive cough associated with tracheo-bronchitis, tracheitis tonsillitis, laryngitis, and pharyngitis associated with inflammat… (Clinical, 2026-04-11)
contraindications: Repeat at intervals of 6 to 12 hours as required. If necessary, increase dose to maximum of 0.05 milligram per pound of body weight. Treatment should not norma… (Official, 2026-04-22)
contraindications: Repeat at intervals of 6 to 12 hours as required. If necessary, increase dose to maximum of 0.05 milligram per pound of body weight. Treatment should not norma… (Official, 2026-02-12)
indications: Butorphanol Tartrate Injection is indicated for the relief of pain associated with colic in adult horses and yearlings. Butorphic Injection is indicated for re… (Official, 2026-08-06)
indications: Butorphanol Tartrate Injection is indicated for the relief of pain associated with colic in adult horses and yearlings. Butorphic Injection is indicated for re… (Official, 2026-08-05)
indications: Butorphanol Tartrate Injection is indicated for the relief of pain associated with colic in adult horses and yearlings. Butorphic Injection is indicated for re… (Official, 2026-08-04)
indications: Butorphanol Tartrate Injection is indicated for the relief of pain associated with colic in adult horses and yearlings. Butorphic Injection is indicated for re… (Official, 2026-08-03)
indications: Butorphanol Tartrate Injection is indicated for the relief of pain associated with colic in adult horses and yearlings. Butorphic Injection is indicated for re… (Official, 2026-08-02)
indications: Butorphanol Tartrate Injection is indicated for the relief of pain associated with colic in adult horses and yearlings. Butorphic Injection is indicated for re… (Official, 2026-08-01)
indications: Butorphanol Tartrate Injection is indicated for the relief of pain associated with colic in adult horses and yearlings. Butorphic Injection is indicated for re… (Official, 2026-07-31)
indications: Butorphanol Tartrate Injection is indicated for the relief of pain associated with colic in adult horses and yearlings. Butorphic Injection is indicated for re… (Official, 2026-07-30)
indications: Butorphanol Tartrate Injection is indicated for the relief of pain associated with colic in adult horses and yearlings. Butorphic Injection is indicated for re… (Official, 2026-07-29)
Recent Revisions
side_effects updated 2026-04-22 10:07 by etl_backfill • Backfilled from existing medication fields
contraindications updated 2026-04-22 10:07 by etl_backfill • Backfilled from existing medication fields
usage updated 2026-04-22 10:07 by etl_backfill • Backfilled from existing medication fields
monitoring updated 2026-04-16 13:28 by curated_loader • Clinical monitoring context for feline diabetes management.
usage updated 2026-04-16 13:28 by curated_loader • Usage statement from FDA warning letter and approved-product context.
drug_profile_type updated 2026-04-16 13:28 by curated_loader • FDA source confirms Senvelgo as a branded approved product.
manufacturer_name updated 2026-04-16 13:28 by curated_loader • FDA warning letter identifies the approved sponsor/manufacturer.
brand_names updated 2026-04-16 13:28 by curated_loader • FDA warning letter references Senvelgo as the approved animal drug.
approval_reference updated 2026-04-16 13:28 by curated_loader • Official FDA application reference for Senvelgo.
side_effects updated 2026-04-15 10:07 by etl_backfill • Backfilled from existing medication fields
contraindications updated 2026-04-15 10:07 by etl_backfill • Backfilled from existing medication fields
usage updated 2026-04-15 10:07 by etl_backfill • Backfilled from existing medication fields
monitoring updated 2026-04-15 10:07 by curated_loader • Clinical monitoring context for feline diabetes management.
usage updated 2026-04-15 10:07 by curated_loader • Usage statement from FDA warning letter and approved-product context.
drug_profile_type updated 2026-04-15 10:07 by curated_loader • FDA source confirms Senvelgo as a branded approved product.
manufacturer_name updated 2026-04-15 10:07 by curated_loader • FDA warning letter identifies the approved sponsor/manufacturer.
brand_names updated 2026-04-15 10:07 by curated_loader • FDA warning letter references Senvelgo as the approved animal drug.
approval_reference updated 2026-04-15 10:07 by curated_loader • Official FDA application reference for Senvelgo.
side_effects updated 2026-04-15 10:04 by etl_backfill • Backfilled from existing medication fields
contraindications updated 2026-04-15 10:04 by etl_backfill • Backfilled from existing medication fields
FDA Products & Applications (Animal Drugs @ FDA)
Official sponsor/proprietary-name/application-status records linked by active ingredient.
Data source: FDA Animal Drugs @ FDA (public search export).
What It's For (FDA Label Highlights)
Extracted from FDA Animal Drugs @ FDA product labeling. Always confirm details with your veterinarian.
Species: Cat
Composition / specifications
Each milliliter of aqueous solution contains 2 milligrams of butorphanol (as butorphanol tartrate).
Cats
Indication
For the relief of pain in cats caused by major or minor trauma, or pain associated with surgical procedures
Dosage
0.2 milligram of butorphanol base activity per pound of body weight (0.4 milligrams per kilogram), using 2 milligrams per milliliter solution. For subcutaneous injection.
Limitations
Dose may be repeated up to 4 times per day. Do not treat for more than 2 days. Safety for use in pregnant female cats, breeding male cats of kittens less than 4 months of age has not been determined. Federal law restricts this drug to use by or on the order of a licensed veterinarian
Each milliliter of aqueous solution contains 10 milligrams of butorphanol (as butorphanol tartrate).
Horses
Indication
For the relief of pain associated with colic and postpartum pain in adult horses and yearlings.
Dosage
0.05 milligram of butorphanol per pound of body weight (0.1 milligram per kilogram of body weight). Dose may be repeated within 3 to 4 hours. Treatment should not exceed 48 hours.
Limitations
Do not use in horses intended for human consumption. Federal law restricts this drug to use by or on the order of a licensed veterinarian.
Each milliliter of aqueous solution contains 10 milligrams of butorphanol (as butorphanol tartrate).
Horses
Indication
For the relief of pain associated with colic and postpartum pain in adult horses and yearlings.
Dosage
0.05 milligram of butorphanol base activity per pound of body weight (0.1 milligram/kilogram) using 10 milligrams per milliliter solution. For intravenous use.
Limitations
Dose may be repeated within 3 to 4 hours. Treatment should not exceed 48 hours. Not for use in horses intended for food. Federal law restricts this drug to use by or on the order of a licensed veterinarian.
Each milliliter of aqueous solution contains 10 milligrams of butorphanol (as butorphanol tartrate).
Horses
Indication
For the relief of pain associated with colic and postpartum pain in adult horses and yearlings.
Dosage
0.05 milligram of butorphanol base activity per pound of body weight (0.1 milligram/kilogram) using 10 milligrams per milliliter solution. For intravenous use.
Limitations
Dose may be repeated within 3 to 4 hours. Treatment should not exceed 48 hours. Not for use in horses intended for food. Federal law restricts this drug to use by or on the order of a licensed veterinarian.
Each milliliter of aqueous solution contains 2 milligrams of butorphanol (as butorphanol tartrate).
Cats
Indication
For the relief of pain in cats caused by major or minor trauma, or pain associated with surgical procedures.
Dosage
0.2 milligram of butorphanol base activity per pound of body weight (0.4 milligrams per kilogram)
Limitations
For subcutaneous injection. Dose may be repeated up to 4 times per day. Do not treat for more than 2 days. Safety for use in pregnant female cats, breeding male cats of kittens less than 4 months of age has not been determined. Federal law restricts this drug to use by or on the order of a licensed veterinarian.
For the relief of chronic nonproductive cough associated with tracheo-bronchitis, tracheitis tonsillitis, laryngitis, and pharyngitis associated with inflammatory conditions of the upper respiratory tract. For the relief of pain associated with colic and postpartum pain in adult horses and yearlings. For the relief of pain in cats caused by major or minor trauma, or pain associated with surgical procedures.
Repeat at intervals of 6 to 12 hours as required. If necessary, increase dose to maximum of 0.05 milligram per pound of body weight. Treatment should not normally be required for longer than 7 days. Federal law restricts this drug to use by or on the order of a licensed veterinarian. For oral use in dogs only. Repeat at intervals of 6 to 12 hours as required. If necessary, increase dose to a maximum of 0.5 milligram per pound of body weight. Treatment should not normally be required for longer than 7 days. Federal law restricts this drug to use by or on the order of a licensed veterinarian. Dose may be repeated within 3 to 4 hours. Treatment should not exceed 48 hours. Not for use in horses intended for food. Federal law restricts this drug to use by or on the order of a licensed veterinarian.
Top Reported Reactions (openFDA)
De-duplicated reaction terms grouped by body system from FDA openFDA reports (not verified; does not prove causation).
Digestive
Loss of appetite (1) • Dog
Showing top 5 for Digestive.
Skin & allergy
Hair loss at application site (1) • Cat
Application site hair loss (1) • Cat
Alopecia local (1) • Dog
Alopecia general (1) • Dog
Showing top 5 for Skin & allergy.
Neurologic
Unsteady walking (1) • Dog
Showing top 5 for Neurologic.
Behavior
Behavioral disorder (1) • Cat
Anxiety (1) • Dog
Showing top 5 for Behavior.
Other
Blood clot (1) • Cat
Basophilia (1) • Cat
Balance problem (1) • Dog
Aspiration pneumonia (1) • Cat
Application site serous discharge (1) • Dog
Show more (19)
Application site reddening (1) • Cat
Application site pain (1) • Dog
Application site lesion (1) • Cat
Application site dry skin (1) • Dog
Application site discharge NOS (1) • Cat
Apnoea (1) • Dog
Anisocoria (1) • Cat
Angioedema (1) • Dog
Anaphylaxis (1) • Cat
Allergy NOS (1) • Dog
Agitation (1) • Cat
Abnormal urine odour (1) • Dog
Abnormal ultrasound finding (1) • Dog
Abnormal Schirmer tear test (1) • Dog
Abnormal radiograph finding (1) • Cat
Abnormal pupil light reflex (1) • Cat
Abnormal movement NOS (1) • Cat
Abnormal cytology (1) • Dog
Abdominal discomfort (1) • Dog
Showing top 5 for Other.
Data source: FDA openFDA Animal & Veterinary adverse event reports.
Adverse Event Case Summaries (openFDA)
These are individual FDA adverse event reports. They are unverified and do not prove the medication caused the reaction.
DysphoriaBehavioral disorder (unspecified)Dilated pupilsLoss of appetiteSkin and tissue infection NOSTiredness (lethargy)
Outcomes: Recovered/Normal
Data source: FDA openFDA Animal & Veterinary adverse event reports.
Overdose Information
No approved overdose-management text is linked yet. If overdose is suspected, contact a veterinarian or emergency clinic immediately.
Storage & Handling
No approved storage guidance is linked yet for this ingredient. Use manufacturer packaging and veterinary guidance for handling/storage.
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Medical Disclaimer: The medication details provided on Roxee are for informational purposes only and are not a substitute for professional veterinary advice. Always consult your veterinarian about your pet's specific needs.