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Roxee Medication Guide

Doxycycline

Medication reference facts with explicit FDA-approval, off-label, source-limited, and safety context. Roxee does not sell, prescribe, or dispense medications.

Both Reference partial Not FDA-approved for animals AX Pharmaceutical Corp Official label facts Owner quick guide first
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Data freshness

Reference facts
Reference refreshed
Aug 6, 2026, 7:47 p.m.

Roxee has a partial reference profile for this medication. Some primary facts still need verification.

FDA applications
FDA application data refreshed
Aug 6, 2026, 7:47 p.m.

Sponsor, product, and application records imported from Animal Drugs @ FDA.

Safety reports
Safety data refreshed
Aug 6, 2026, 7:49 p.m.

openFDA reaction terms and case summaries are supporting evidence, not proof of causality.

Source timing details
Source timing details
  • Reference facts: Source Roxee | Refreshed Aug 6, 2026, 7:47 PM UTC
    The reference fact projection used for browse cards and quick facts.
  • Animal Drug Product Listing Directory (NDC): Source FDA | Refreshed Aug 6, 2026, 7:47 PM UTC
    Package/product NDCs from FDA’s electronic listing directory (XLS).
  • openFDA reaction terms: Source FDA openFDA | Refreshed Aug 6, 2026, 7:52 PM UTC
  • openFDA case summaries: Source FDA openFDA | Refreshed Aug 6, 2026, 7:52 PM UTC
Illustration placeholder
Doxycycline

Doxycycline

Drug type: Generic ingredient • Branded profile • Not FDA-approved for animals

Both 85% reference complete

Species: Both

Approval status: Not FDA-approved as an animal drug. No FDA-approved animal-drug application is linked for this record. It may represent extra-label, human-drug, bulk-compounding, export-only, or otherwise unapproved animal-use source data; use only under veterinarian direction.

Medication Snapshot

Merged from the current Roxee medication system with field-level provenance, freshness, and completeness tracking.

Doxycycline

Tetracycline antibiotic used for a variety of infections (often tick-borne diseases in dogs). Species commonly shown: Both.

Generic name
Doxycycline
Brand names
Doxycycline Monohydrate, AX Pharmaceutical Corp
Manufacturer
AX Pharmaceutical Corp
Species
Both
Completeness
85%
Validation
Incomplete
Brand names
Doxycycline Monohydrate AX Pharmaceutical Corp

Indications / Uses

Tetracycline antibiotic used for a variety of infections (often tick-borne diseases in dogs).

Administration / How To Give

Oral

Storage

Store at room temperature; protect from moisture.

Warnings / Contraindications

Use caution in young animals and in pregnancy. In cats, dry pilling can cause esophageal injury.

  • Use caution in young animals and in pregnancy. In cats, dry pilling can cause esophageal injury.

Side Effects

GI upset; photosensitivity.

FAQ

Both

Store at room temperature; protect from moisture.

Related Medications

Afoxolaner Same category: Flea & Tick Fluralaner 13.64% 12-Week Chew Same category: Flea & Tick Fluralaner Chew Tablets Same category: Flea & Tick Fluralaner Spot-On Solution Same category: Flea & Tick Imidacloprid Same category: Flea & Tick Lotilaner Same category: Flea & Tick

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Pet Owner Quick Guide

Start here first for the safest next-step summary before the deeper medication detail.

Used for:

Tetracycline antibiotic used for a variety of infections (often tick-borne diseases in dogs).

Dosing note:

Exact dosing depends on your pet's species, weight, and health status. Use your veterinarian's instructions for the exact dose and schedule.

What to watch for:

  • Use caution in young animals and in pregnancy
  • In cats, dry pilling can cause esophageal injury
  • Loss of appetite (1 reports)
  • Decreased haematocrit (1 reports)
  • Decreased appetite (1 reports)

When to call the vet:

  • Repeated vomiting or diarrhea.
  • Severe lethargy (hard to wake, very low energy).
  • Collapse or fainting.
  • Trouble breathing.
  • Facial swelling or hives.
  • Blood in vomit or stool.

What to tell or ask your vet today:

  • Is this medicine the right fit for my pet’s current symptoms?
  • Which warning signs mean I should call back right away?
  • How should I handle missed doses or refusal to take the medicine?

Next actions

Talk to a Vet / Find a Vet Near You Save to pet meds Share page Review report evidence
Research brief

Medication Research Insights

A source-aware map of what to know, what is uncertain, and what to verify with your veterinarian.

Source Backed Signals

What to know

Evidence-backed context Limited

Roxee has limited cited overview evidence for Doxycycline; use the official documents and your veterinarian's instructions for product-specific decisions.

Source: openFDA case USA-USFDACVM-2025-US-070810
Safety signal coverage Reported signals

32 tracked reaction signals; 32 reported cases; 24 serious reports; 2 species groups. These are reporting and label-derived signals for interpretation with a veterinarian.

Source: openFDA case USA-USFDACVM-2025-US-070810
Interpretation guardrail Not causation

Adverse-event reports help form a watch list, but they do not prove the medication caused the reaction and they are not a risk ranking between medications.

Evidence tension

Stronger signal Label / review

Official labels, package inserts, and reviewed summaries carry more weight than isolated reports.

Source: openFDA case USA-USFDACVM-2025-US-070810
Weaker signal Reported data

Case reports and openFDA terms are useful for pattern awareness, but they are incomplete, can include multiple exposures, and do not estimate an individual pet's probability of harm.

Reaction signal map

Most reported reactions Top terms

Loss of appetite (1 reports), Decreased haematocrit (1 reports), Decreased appetite (1 reports), Death by euthanasia (1 reports), Death (1 reports)

Body systems represented Signal grouping

Digestive (3), Skin & allergy (1), Neurologic (1), Behavior (1)

Explore supporting adverse reports

Species and breed lens

Species represented in reports Species lens

Dog (21 reports), Cat (11 reports)

Breed metadata in reports Metadata only

['Pit Bull', 'Dog (unknown)'] (1), ['Chihuahua', 'Dog (unknown)'] (1), Retriever - Labrador (1), Pit Bull (1). These are report metadata, not proof that a breed is at higher risk.

What your vet may verify

Fit for this patient Vet check

Verify whether Doxycycline fits the pet's species, current diagnosis, age, weight, organ status, pregnancy/lactation status, and concurrent medications.

Evidence limitations Evidence review

Separate label-backed warnings from adverse-event reports and owner observations before changing the plan.

What to watch next

Watch list Owner-safe

Use caution in young animals and in pregnancy, In cats, dry pilling can cause esophageal injury, Loss of appetite, Decreased haematocrit, Decreased appetite

Call sooner if Escalation

Repeated vomiting or diarrhea. Severe lethargy (hard to wake, very low energy). Collapse or fainting.

Bottom line: Use this Doxycycline brief as a structured watch list and source map, not as a reason to start, stop, or change treatment without your veterinarian.
Vet source depth
  1. openFDA case USA-USFDACVM-2025-US-070810 · adverse_reaction · adverse reactions
  2. Medication contraindications · safety_warning · warnings contraindications
  3. Structured Product Label · document · documents
  4. Structured Product Label · document · documents
  5. FOI summary · document · documents

Evidence

Review status / Updated / Sources

Review status: Clinical reviewer not listed

Updated: April 15, 2026, 10:04 AM UTC

Sources:
Safety & side effects

Side effects to monitor:

  • Use caution in young animals and in pregnancy
  • In cats, dry pilling can cause esophageal injury
  • Loss of appetite
  • Decreased haematocrit
  • Decreased appetite

Most reported reactions:

  • Loss of appetite (1 reports)
  • Decreased haematocrit (1 reports)
  • Decreased appetite (1 reports)
Explore reported case details

Emergency warning signs:

  • Repeated vomiting or diarrhea.
  • Severe lethargy (hard to wake, very low energy).
  • Collapse or fainting.
  • Trouble breathing.
Talk to a Vet / Find a Vet Near You Start Symptom Intake

Vet Fast Scan

Source-backed clinical checkpoints for quick review.

FDA-labeled species
Not linked yet
Indication / use
Tetracycline antibiotic used for a variety of infections (often tick-borne diseases in dogs).
Form / route / dose
Confirm product label and patient-specific plan.
Warnings
  • High: Use caution in young animals and in pregnancy. In cats, dry pilling can cause esophageal injury.
Adverse-event caveat
openFDA adverse-event cases are reported signals. They are not verified, do not prove causation, and do not estimate a pet's individual risk.
Source docs

Quick Facts

Official label facts first, then secondary summaries. Marketing content is separated below.

Species: Both
Manufacturer: AX Pharmaceutical Corp
Identifiers:
NADA: 141082 NDC Package: 17163-017-16 NDC Package: 43457-541-25 NDC Package: 46144-604-01 NDC Package: 54771-5193-1 NDC Package: 58645-005-01 NDC Package: 62157-482-01 NDC Package: 62157-538-01 NDC Package: 62157-816-01 NDC Package: 73377-033-01 NDC Package: 73377-033-02 NDC Package: 73377-033-03 NDC Product: 17163 NDC Product: 43457 NDC Product: 46144 NDC Product: 54771 NDC Product: 58645 NDC Product: 62157 NDC Product: 73377

Warnings / Contraindications

Use caution in young animals and in pregnancy. In cats, dry pilling can cause esophageal injury.

  • High: Use caution in young animals and in pregnancy. In cats, dry pilling can cause esophageal injury.
Source metadata:

Adverse Reactions

Snapshot first, detailed rows second. This section summarizes signal data and is not a diagnosis.

Reported case explorer

Filter stored openFDA reports by pet and report attributes. Counts describe reports in this data set, not risk.

Clear filters
openFDA adverse-event cases are reported signals. They are not verified, do not prove causation, and do not estimate a pet's individual risk.
Stored reports
31
Matching reports
0
Active filters
2
Selected filters
Reaction: Intentional misuse Clear Body system: Neurologic Clear
Reset
Drill into common report signals
Not eating (9) Intentional misuse (7) Lack of efficacy (endoparasite) - heartworm (7) Death by euthanasia (6) Other (27) Effectiveness (12) Digestive (8) Neurologic (7)
No stored openFDA reports match the selected filters. openFDA adverse-event cases are reported signals. They are not verified, do not prove causation, and do not estimate a pet's individual risk.

Tap or hover a reaction to see what it means in plain language.

Tracked signals
32
Reported cases
32
Serious reports
24
Species represented
2
Grouped by Body System
Digestive (3) · Loss of appetite, Decreased appetite, Blood in vomit Skin & allergy (1) · Application site hair loss Neurologic (1) · Unsteady walking (ataxia) Behavior (1) · Anxiety Other (26) · Decreased haematocrit, Death by euthanasia, Death
Most Reported Reactions
Reaction Body system Cases Species Serious cases
Digestive 1 Dog 1
Other 1 Dog 1
Digestive 1 Dog 1
Other 1 Cat 1
Other 1 Dog 1
Other 1 Dog 1
Other 1 Dog 1
Other 1 Dog 1

Species coverage: Dog (21) Cat (11)

View detailed reaction table
Reaction Body system Species Seriousness Frequency Reports
Neurologic Cat Non-serious - 1
Digestive Dog Serious - 1
Other Dog Serious - 1
Digestive Dog Serious - 1
Other Cat Serious - 1
Other Dog Serious - 1
Other Dog Serious - 1
Other Dog Serious - 1
Other Dog Serious - 1
Other Dog Serious - 1
Other Dog Serious - 1
Other Dog Serious - 1
Other Dog Non-serious - 1
Other Cat Serious - 1
Other Dog Serious - 1
Other Dog Serious - 1
Digestive Cat Serious - 1
Other Cat Non-serious - 1
Other Cat Non-serious - 1
Other Cat Non-serious - 1
Other Dog Serious - 1
Other Cat Non-serious - 1
Skin & allergy Cat Non-serious - 1
Behavior Dog Serious - 1
Other Dog Serious - 1
Other Cat Serious - 1
Other Dog Non-serious - 1
Other Dog Serious - 1
Other Dog Serious - 1
Other Dog Serious - 1
Other Cat Serious - 1
Other Dog Serious - 1
Source metadata:

Storage & Handling

Store at room temperature; protect from moisture.

Source Documents

The most useful source links appear first; full previews and metadata stay in the veterinary/professional layer.

Use original documents to confirm product-specific warnings, ingredients, and handling details with your veterinarian.

AX Pharmaceutical Corp SPL SPL · Structured Product Label Doxycycline Monohydrate SPL SPL · Structured Product Label UCM437264.pdf FOI · FOI summary

Full source previews and metadata remain in the veterinary/professional layer.

Owner handouts

0
No owner handouts linked yet.

Official label / PI

0
No official label or package insert links yet.

SPL

2

FOI

1

AX Pharmaceutical Corp SPL

SPL · Structured Product Label

Open original
FDA Structured Product Label XML for AX Pharmaceutical Corp. Use the source link for the full official labeling record.

Doxycycline Monohydrate SPL

SPL · Structured Product Label

Open original
FDA Structured Product Label XML for Doxycycline Monohydrate. Use the source link for the full official labeling record.

UCM437264.pdf

FOI · FOI summary

Open original
Source metadata:
Veterinary reference (advanced)

Canonical medication sections are above. This legacy block remains available for deeper cross-reference without cluttering the primary workflow.

At a Glance

Quick facts and links to official labeling and safety signals.

Data freshness
  • Reference facts: Source Roxee | Refreshed Aug 6, 2026, 7:47 PM UTC
    The reference fact projection used for browse cards and quick facts.
  • Animal Drug Product Listing Directory (NDC): Source FDA | Refreshed Aug 6, 2026, 7:47 PM UTC
    Package/product NDCs from FDA’s electronic listing directory (XLS).
  • openFDA reaction terms: Source FDA openFDA | Refreshed Aug 6, 2026, 7:52 PM UTC
  • openFDA case summaries: Source FDA openFDA | Refreshed Aug 6, 2026, 7:52 PM UTC
Official (FDA)
Identity: Generic ingredient • FDA branded products available
Official FDA brands: AX Pharmaceutical Corp Doxycycline Monohydrate
Manufacturer mapping: AX Pharmaceutical Corp
Case-reported brands (openFDA): MSK
Catalog species: Both
NDC: Packages 62157-538-01 62157-816-01 • Products 62157
Safety (openFDA)
Top reactions: Dog 138 • Cat 37 • View
Case summaries: 31 (showing 8) • View
openFDA reports are unverified and do not prove causation.
Diagnosis Codes
ICD10_CM: K05.6
Periodontal disease, unspecified

Counseling and Monitoring Highlights

Global Pet owner/Vet mode is controlled in the header. This section avoids duplicate in-page persona tabs.

Owner-facing counseling points
  • Use caution in young animals and in pregnancy. In cats, dry pilling can cause esophageal injury. (Contraindication, High)
Top reaction signals
Loss of appetite (1) Decreased haematocrit (1) Decreased appetite (1) Death by euthanasia (1) Death (1) Coughing up blood (1) Cough (1) Corneal opacity (1)

Identifiers & Packages

Normalized identifiers (NDC/NADA/ANADA) and package metadata from regulator listings.

Identifiers
NADA: 141082 NDC Package: 17163-017-16 NDC Package: 43457-541-25 NDC Package: 46144-604-01 NDC Package: 54771-5193-1 NDC Package: 58645-005-01 NDC Package: 62157-482-01 NDC Package: 62157-538-01 NDC Package: 62157-816-01 NDC Package: 73377-033-01 NDC Package: 73377-033-02 NDC Package: 73377-033-03 NDC Product: 17163 NDC Product: 43457 NDC Product: 46144 NDC Product: 54771 NDC Product: 58645 NDC Product: 62157 NDC Product: 73377
Package NDC Product NDC Form / Route Status
17163-017-16 17163 -
43457-541-25 43457 -
46144-604-01 46144 -
54771-5193-1 54771 -
58645-005-01 58645 -
62157-482-01 62157 -
62157-538-01 62157 -
62157-816-01 62157 -
73377-033-01 73377 -
73377-033-02 73377 -
73377-033-03 73377 -

Enriched Documents

Documents are tiered by source trust: Official, Clinical, Manufacturer, Marketing.

  • AX Pharmaceutical Corp SPL • Structured Product Label • Official
    FDA Structured Product Label from the electronic animal drug product listing directory.
  • Doxycycline Monohydrate SPL • Structured Product Label • Official
    FDA Structured Product Label from the electronic animal drug product listing directory.
  • UCM437264.pdf • FOI summary • Official • June 1, 2016
    FDA FOI summary for application 141082

Data Sources & Change Log

Every non-trivial field is expected to include provenance and update timestamps.

Official 3 Clinical 120 Manufacturer 0 Marketing 0
Current Field Facts
  • contraindications: Use caution in young animals and in pregnancy. In cats, dry pilling can cause esophageal injury. (Clinical, 2026-07-22)
  • contraindications: Use caution in young animals and in pregnancy. In cats, dry pilling can cause esophageal injury. (Clinical, 2026-07-22)
  • contraindications: Use caution in young animals and in pregnancy. In cats, dry pilling can cause esophageal injury. (Clinical, 2026-07-22)
  • contraindications: Use caution in young animals and in pregnancy. In cats, dry pilling can cause esophageal injury. (Clinical, 2026-07-20)
  • contraindications: Use caution in young animals and in pregnancy. In cats, dry pilling can cause esophageal injury. (Clinical, 2026-07-19)
  • contraindications: Use caution in young animals and in pregnancy. In cats, dry pilling can cause esophageal injury. (Clinical, 2026-07-16)
  • contraindications: Use caution in young animals and in pregnancy. In cats, dry pilling can cause esophageal injury. (Clinical, 2026-07-16)
  • contraindications: Use caution in young animals and in pregnancy. In cats, dry pilling can cause esophageal injury. (Clinical, 2026-07-13)
  • contraindications: Use caution in young animals and in pregnancy. In cats, dry pilling can cause esophageal injury. (Clinical, 2026-07-12)
  • contraindications: Use caution in young animals and in pregnancy. In cats, dry pilling can cause esophageal injury. (Clinical, 2026-07-11)
  • contraindications: Use caution in young animals and in pregnancy. In cats, dry pilling can cause esophageal injury. (Clinical, 2026-07-11)
  • contraindications: Use caution in young animals and in pregnancy. In cats, dry pilling can cause esophageal injury. (Clinical, 2026-07-11)
  • contraindications: Use caution in young animals and in pregnancy. In cats, dry pilling can cause esophageal injury. (Clinical, 2026-07-10)
  • contraindications: Use caution in young animals and in pregnancy. In cats, dry pilling can cause esophageal injury. (Clinical, 2026-07-07)
  • contraindications: Use caution in young animals and in pregnancy. In cats, dry pilling can cause esophageal injury. (Clinical, 2026-07-06)
  • contraindications: Use caution in young animals and in pregnancy. In cats, dry pilling can cause esophageal injury. (Clinical, 2026-07-06)
  • contraindications: Use caution in young animals and in pregnancy. In cats, dry pilling can cause esophageal injury. (Clinical, 2026-07-03)
  • contraindications: Use caution in young animals and in pregnancy. In cats, dry pilling can cause esophageal injury. (Clinical, 2026-07-03)
  • contraindications: Use caution in young animals and in pregnancy. In cats, dry pilling can cause esophageal injury. (Clinical, 2026-07-02)
  • contraindications: Use caution in young animals and in pregnancy. In cats, dry pilling can cause esophageal injury. (Clinical, 2026-07-01)
Recent Revisions
  • side_effects updated 2026-07-22 19:08 by etl_backfill • Backfilled from existing medication fields
  • contraindications updated 2026-07-22 19:08 by etl_backfill • Backfilled from existing medication fields
  • usage updated 2026-07-22 19:08 by etl_backfill • Backfilled from existing medication fields
  • side_effects updated 2026-07-22 18:40 by etl_backfill • Backfilled from existing medication fields
  • contraindications updated 2026-07-22 18:40 by etl_backfill • Backfilled from existing medication fields
  • usage updated 2026-07-22 18:40 by etl_backfill • Backfilled from existing medication fields
  • side_effects updated 2026-07-22 08:29 by etl_backfill • Backfilled from existing medication fields
  • contraindications updated 2026-07-22 08:29 by etl_backfill • Backfilled from existing medication fields
  • usage updated 2026-07-22 08:29 by etl_backfill • Backfilled from existing medication fields
  • side_effects updated 2026-07-20 10:05 by etl_backfill • Backfilled from existing medication fields
  • contraindications updated 2026-07-20 10:05 by etl_backfill • Backfilled from existing medication fields
  • usage updated 2026-07-20 10:05 by etl_backfill • Backfilled from existing medication fields
  • side_effects updated 2026-07-19 13:48 by etl_backfill • Backfilled from existing medication fields
  • contraindications updated 2026-07-19 13:48 by etl_backfill • Backfilled from existing medication fields
  • usage updated 2026-07-19 13:48 by etl_backfill • Backfilled from existing medication fields
  • side_effects updated 2026-07-16 16:34 by etl_backfill • Backfilled from existing medication fields
  • contraindications updated 2026-07-16 16:34 by etl_backfill • Backfilled from existing medication fields
  • usage updated 2026-07-16 16:34 by etl_backfill • Backfilled from existing medication fields
  • side_effects updated 2026-07-16 15:43 by etl_backfill • Backfilled from existing medication fields
  • contraindications updated 2026-07-16 15:43 by etl_backfill • Backfilled from existing medication fields

FDA Products & Applications (Animal Drugs @ FDA)

Official sponsor/proprietary-name/application-status records linked by active ingredient.

Product Sponsor Application Status Published

Data source: FDA Animal Drugs @ FDA (public search export).

Usage

Tetracycline antibiotic used for a variety of infections (often tick-borne diseases in dogs).

Contraindications

Use caution in young animals and in pregnancy. In cats, dry pilling can cause esophageal injury.

Side Effects

GI upset; photosensitivity.

Source: FDA openFDA • Reference

Top Reported Reactions (openFDA)

De-duplicated reaction terms grouped by body system from FDA openFDA reports (not verified; does not prove causation).

Digestive
Loss of appetite (1) • Dog Decreased appetite (1) • Dog Blood in vomit (1) • Cat

Showing top 5 for Digestive.

Skin & allergy
Application site hair loss (1) • Cat

Showing top 5 for Skin & allergy.

Neurologic
Unsteady walking (1) • Cat

Showing top 5 for Neurologic.

Behavior
Anxiety (1) • Dog

Showing top 5 for Behavior.

Other
Decreased haematocrit (1) • Dog Death by euthanasia (1) • Cat Death (1) • Dog Coughing up blood (1) • Dog Cough (1) • Dog
Show more (21)
Corneal opacity (1) • Dog Corneal oedema (1) • Dog Conjunctival oedema (1) • Dog Cloudy eye (1) • Dog Cellulitis (1) • Dog Bradycardia (1) • Cat Bone and joint disorder NOS (1) • Dog Bloody stool (1) • Dog Blood in urine (1) • Cat Barbering (1) • Cat Balance impaired (1) • Cat Arthritis (1) • Dog Application site scab (1) • Cat Angioedema (1) • Dog Anaemia NOS (1) • Cat Acidic urine (1) • Dog Abnormal ultrasound finding (1) • Dog Abnormal radiograph finding (1) • Dog Abnormal breathing (1) • Dog Abdominal pain (1) • Cat Abdominal discomfort (1) • Dog

Showing top 5 for Other.

Data source: FDA openFDA Animal & Veterinary adverse event reports.

Adverse Event Case Summaries (openFDA)

These are individual FDA adverse event reports. They are unverified and do not prove the medication caused the reaction.

Dog, ['Pit Bull', 'Dog (unknown)'], Female, 4.5 year, 18.869 kilogram • Drug: MSK, Unknown • Reactions: Decreased appetite, Ear infection NOS, Other abnormal test result NOS, Loose stool, Falling… • Outcome: Died

  • Report ID: USA-USFDACVM-2026-US-013847
  • Serious AE: Yes
  • Treated For AE: Yes
  • Sex: Female
  • Age: 4.50 Year
  • Weight: 18.869 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Unknown
Reactions Reported:
Decreased appetite Ear infection NOS Other abnormal test result NOS Loose stool Falling Vomiting Weakness Death Elevated creatinine Elevated renal parameters UNPALATABLE
Outcomes: Died

Dog, ['Chihuahua', 'Dog (unknown)'], Female, 3 year, 10.795 kilogram • Drug: MSK, Unassigned, Unknown • Reactions: Lack of efficacy (endoparasite) - heartworm, Intentional misuse • Outcome: Ongoing

  • Report ID: USA-USFDACVM-2026-US-013422
  • Serious AE: Yes
  • Treated For AE: Yes
  • Sex: Female
  • Age: 3.00 Year
  • Weight: 10.795 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Unknown
  • Form: Unassigned
Reactions Reported:
Lack of efficacy (endoparasite) - heartworm Intentional misuse
Outcomes: Ongoing

Dog, Retriever - Labrador, Male, 8 year, 33.929 kilogram • Drug: MSK, Unassigned, Oral • Reactions: Seizure NOS, Elevated liver enzymes NOS • Outcome: Ongoing

  • Report ID: USA-USFDACVM-2026-US-013496
  • Serious AE: Yes
  • Treated For AE: Yes
  • Sex: Male
  • Age: 8.00 Year
  • Weight: 33.929 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Oral
  • Form: Unassigned
Reactions Reported:
Seizure NOS Elevated liver enzymes NOS
Outcomes: Ongoing

Dog, Pit Bull, Female, 8.58 year • Drug: MSK, Unknown, Dose: 100 Milligram per animal • Reactions: Cough, Death by euthanasia, Low platelet count, Pulmonary oedema, Coughing up blood… • Outcome: Euthanized

  • Report ID: USA-USFDACVM-2026-US-014254
  • Serious AE: Yes
  • Treated For AE: Yes
  • Sex: Female
  • Age: 8.58 Year
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Unknown
  • Dose: 100 Milligram per animal
Reactions Reported:
Cough Death by euthanasia Low platelet count Pulmonary oedema Coughing up blood Respiratory distress
Outcomes: Euthanized

Dog, ['Chihuahua', 'Dachshund (unspecified)'], Male, 2 year, 5.761 kilogram • Drug: MSK, Unassigned, Oral • Reactions: Lack of efficacy (endoparasite) - heartworm, Medication error NOS, Intentional misuse, Lack of efficacy (endoparasite) - roundworm NOS • Outcome: Ongoing

  • Report ID: USA-USFDACVM-2026-US-012896
  • Serious AE: Yes
  • Treated For AE: Yes
  • Sex: Male
  • Age: 2.00 Year
  • Weight: 5.761 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Oral
  • Form: Unassigned
Reactions Reported:
Lack of efficacy (endoparasite) - heartworm Medication error NOS Intentional misuse Lack of efficacy (endoparasite) - roundworm NOS
Outcomes: Ongoing

Dog, Cattle Dog - Australian (blue heeler, red heeler, Queensland cattledog), Male, 10 year, 26.26 kilogram • Drug: MSK, Unassigned, Oral • Reactions: Vomiting, Not eating, Bloody stool, Haematemesis, Anxiety… • Outcome: Ongoing

  • Report ID: USA-USFDACVM-2026-US-013808
  • Serious AE: Yes
  • Treated For AE: Yes
  • Sex: Male
  • Age: 10.00 Year
  • Weight: 26.260 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Oral
  • Form: Unassigned
Reactions Reported:
Vomiting Not eating Bloody stool Haematemesis Anxiety Lack of efficacy - NOS Intentional misuse Low thyroxine Elevated blood urea nitrogen Elevated amylase Gastritis
Outcomes: Ongoing

Dog, ['Siberian Husky', 'Shepherd Dog - German'], Male, 9 year, 41.277 kilogram • Drug: MSK, Oral • Reactions: Other abnormal test result NOS, Lack of efficacy (endoparasite) - heartworm, Tiredness (lethargy), Death by euthanasia, Blood in urine… • Outcome: Euthanized

  • Report ID: USA-USFDACVM-2026-US-014359
  • Serious AE: Yes
  • Treated For AE: Yes
  • Sex: Male
  • Age: 9.00 Year
  • Weight: 41.277 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Oral
Reactions Reported:
Other abnormal test result NOS Lack of efficacy (endoparasite) - heartworm Tiredness (lethargy) Death by euthanasia Blood in urine Cloudy eye Cough Swelling NOS Corneal opacity Urine abnormalities NOS Weakness Increased lung sounds Haemolytic anaemia Not eating Abnormal breathing Walking difficulty Decreased red blood cell count Decreased percentage of reticulocytes
Outcomes: Euthanized

Dog, Spitz - German Pomeranian, Female, 12 year, 3.357 kilogram • Drug: MSK, Unassigned, Unknown • Reactions: Unable to stand, Head down, Not drinking, Reluctant to move, Intentional misuse • Outcome: Ongoing

  • Report ID: USA-USFDACVM-2026-US-011643
  • Serious AE: No
  • Treated For AE: No
  • Sex: Female
  • Age: 12.00 Year
  • Weight: 3.357 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Unknown
  • Form: Unassigned
Reactions Reported:
Unable to stand Head down Not drinking Reluctant to move Intentional misuse
Outcomes: Ongoing

Data source: FDA openFDA Animal & Veterinary adverse event reports.

Overdose Information

No approved overdose-management text is linked yet. If overdose is suspected, contact a veterinarian or emergency clinic immediately.

Storage & Handling

Store at room temperature; protect from moisture.

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