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Roxee Meds Catalog

Fipronil 10%/S Methoprene 9% Spot On

Medication catalog facts with explicit FDA-approval, off-label, source-limited, and safety context.

Both Source review pending Source coverage pending Owner quick guide first
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Showing simplified owner view. Switch to Vet View for full technical detail.

Data freshness

Storefront facts
Source review pending
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Roxee is still reviewing source support for this medication profile.

FDA applications
Regulatory match pending
No refresh timestamp yet

Roxee has safety or ingredient evidence for this medication, but a regulatory product/application match is still pending.

Safety reports
Safety data refreshed
Apr 27, 2026, 10:02 a.m.

openFDA reaction terms and case summaries are supporting evidence, not proof of causality.

Source timing details
Source timing details
  • Storefront facts: Source Roxee | Refreshed May 5, 2026, 10:05 AM UTC
    The storefront fact projection used for browse cards and quick facts.
  • openFDA reaction terms: Source FDA openFDA | Refreshed May 5, 2026, 10:04 AM UTC
  • openFDA case summaries: Source FDA openFDA | Refreshed May 5, 2026, 10:04 AM UTC

Evidence

Reviewed / Updated / Sources

Reviewed by: Not available

Last reviewed: April 22, 2026

Updated: April 22, 2026, 10:07 AM UTC

Sources:
Image coming soon
Fipronil 10%/S Methoprene 9% Spot On

Fipronil 10%/S Methoprene 9% Spot On

Drug type: Generic ingredient • Generic profile • Source coverage pending

Both 58% storefront ready

Species: Both

Approval status: Source coverage pending. Roxee has limited supporting content for this record, but no on-page official FDA animal-drug document is linked yet. Treat it as source-limited until the ETL backfill adds official coverage.

Medication Snapshot

Merged from the current Roxee medication system with field-level provenance, freshness, and completeness tracking.

Fipronil 10%/S Methoprene 9% Spot On

Generic name
Fipronil 10%/S Methoprene 9% Spot On
Species
Both
Completeness
58%
Validation
Incomplete

Side Effects

Top reported reactions (openFDA): Vomiting, Lack of efficacy (ectoparasite) - flea, Lethargy (see also Central nervous system depression in 'Neurological'), Lack of efficacy (flea), Skin disorders NOS, Seizure NOS.

FAQ

Both

Source Transparency

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Pet Owner Quick Guide

Start here first for the safest next-step summary before the deeper medication detail.

Roxee still has limited plain-language guidance for this medication. Use the official documents and your veterinarian's instructions for product-specific details.

Used for:

Your vet decides this. Here's what owners typically ask/watch for.

Dosing note:

Exact dosing depends on your pet's species, weight, and health status. Use your veterinarian's instructions for the exact dose and schedule.

What to watch for:

  • Tremors (1 reports)
  • Musculoskeletal disorder NOS (1 reports)
  • Disorientation (1 reports)

When to call the vet:

  • Repeated vomiting or diarrhea.
  • Severe lethargy (hard to wake, very low energy).
  • Collapse or fainting.
  • Trouble breathing.
  • Facial swelling or hives.
  • Blood in vomit or stool.

What to tell or ask your vet today:

  • Is this medicine the right fit for my pet’s current symptoms?
  • Which warning signs mean I should call back right away?
  • How should I handle missed doses or refusal to take the medicine?
Major cautions & emergency warning signs

Side effects to monitor:

  • Tremors
  • Musculoskeletal disorder NOS
  • Disorientation

Most reported reactions:

  • Tremors (1 reports)
  • Musculoskeletal disorder NOS (1 reports)
  • Disorientation (1 reports)

Emergency warning signs:

  • Repeated vomiting or diarrhea.
  • Severe lethargy (hard to wake, very low energy).
  • Collapse or fainting.
  • Trouble breathing.
Talk to a Vet / Find a Vet Near You Start Symptom Intake

Quick Facts

Official label facts first, then secondary summaries. Marketing content is separated below.

Species: Both
Manufacturer: Manufacturer not confirmed

Adverse Reactions

Snapshot first, detailed rows second. This section summarizes signal data and is not a diagnosis.

Tap or hover a reaction to see what it means in plain language.

Tracked signals
20
Reported cases
9
Serious reports
3
Species represented
2
Grouped by Body System
Digestive (3) · Vomiting, Loss of appetite, Drooling Skin & allergy (2) · Localised hair loss, Itching Neurologic (3) · Tremors, Seizure NOS, Lethargy (see also Central nervous system depression in 'Neurological') Behavior (1) · Behavioral disorder (unspecified) Effectiveness (2) · Lack of efficacy (ectoparasite) - flea, Lack of efficacy (flea) Other (9) · Skin lesion NOS, Shaking, Musculoskeletal disorder NOS
Most Reported Reactions
Reaction Body system Cases Species Serious cases
Neurologic 1 Dog 1
Other 1 Dog 1
Other 1 Dog 1
Other 1 Dog 0
Other 1 Dog 0
Skin & allergy 1 Cat 0
Effectiveness 1 Cat 0
Skin & allergy 1 Dog 0

Species coverage: Dog (18) Cat (2)

View detailed reaction table
Reaction Body system Species Seriousness Frequency Reports
Neurologic Dog Serious - 1
Other Dog Non-serious - 1
Other Dog Non-serious - 1
Other Dog Serious - 1
Skin & allergy Cat Non-serious - 1
Effectiveness Cat Non-serious - 1
Skin & allergy Dog Non-serious - 1
Other Dog Non-serious - 1
Other Dog Serious - 1
Digestive Dog Unknown - -
Other Dog Unknown - -
Other Dog Unknown - -
Neurologic Dog Unknown - -
Other Dog Unknown - -
Digestive Dog Unknown - -
Neurologic Dog Unknown - -
Other Dog Unknown - -
Effectiveness Dog Unknown - -
Digestive Dog Unknown - -
Behavior Dog Unknown - -
Source metadata:
Veterinary reference (advanced)

Canonical medication sections are above. This legacy block remains available for deeper cross-reference without cluttering the primary workflow.

At a Glance

Quick facts and links to official labeling and safety signals.

Data freshness
  • Storefront facts: Source Roxee | Refreshed May 5, 2026, 10:05 AM UTC
    The storefront fact projection used for browse cards and quick facts.
  • openFDA reaction terms: Source FDA openFDA | Refreshed May 5, 2026, 10:04 AM UTC
  • openFDA case summaries: Source FDA openFDA | Refreshed May 5, 2026, 10:04 AM UTC
Official (FDA)
Identity: Generic ingredient • No FDA branded products linked
No official FDA brand rows linked yet for this ingredient.
Case-reported brands (openFDA): MSK
Catalog species: Both
Safety (openFDA)
Top reactions: Dog 0 • Cat 1 • View
Case summaries: 1 (showing 1) • View
openFDA reports are unverified and do not prove causation.
Diagnosis Codes

Diagnosis-code mappings are not available for this medication yet.

Counseling and Monitoring Highlights

Global Pet owner/Vet mode is controlled in the header. This section avoids duplicate in-page persona tabs.

Top reaction signals
Tremors (1) Musculoskeletal disorder NOS (1) Disorientation (1) Skin lesion NOS (1) Shaking (1) Localised hair loss (1) Lack of efficacy (ectoparasite) - flea (1) Itching (1)

Data Sources & Change Log

Every non-trivial field is expected to include provenance and update timestamps.

Official 10 Clinical 2 Manufacturer 0 Marketing 0
Current Field Facts
  • side_effects: Top reported reactions (openFDA): Vomiting, Lack of efficacy (ectoparasite) - flea, Lethargy (see also Central nervous system depression in 'Neurological'), La… (Clinical, 2026-04-15)
  • side_effects: Top reported reactions (openFDA): Vomiting, Lack of efficacy (ectoparasite) - flea, Lethargy (see also Central nervous system depression in 'Neurological'), La… (Clinical, 2026-04-11)
  • side_effects: Top reported reactions (openFDA): Vomiting, Lack of efficacy (ectoparasite) - flea, Lethargy (see also Central nervous system depression in 'Neurological'), La… (Official, 2026-05-05)
  • side_effects: Top reported reactions (openFDA): Vomiting, Lack of efficacy (ectoparasite) - flea, Lethargy (see also Central nervous system depression in 'Neurological'), La… (Official, 2026-05-03)
  • side_effects: Top reported reactions (openFDA): Vomiting, Lack of efficacy (ectoparasite) - flea, Lethargy (see also Central nervous system depression in 'Neurological'), La… (Official, 2026-04-30)
  • side_effects: Top reported reactions (openFDA): Vomiting, Lack of efficacy (ectoparasite) - flea, Lethargy (see also Central nervous system depression in 'Neurological'), La… (Official, 2026-04-29)
  • side_effects: Top reported reactions (openFDA): Vomiting, Lack of efficacy (ectoparasite) - flea, Lethargy (see also Central nervous system depression in 'Neurological'), La… (Official, 2026-04-28)
  • side_effects: Top reported reactions (openFDA): Vomiting, Lack of efficacy (ectoparasite) - flea, Lethargy (see also Central nervous system depression in 'Neurological'), La… (Official, 2026-04-27)
  • side_effects: Top reported reactions (openFDA): Vomiting, Lack of efficacy (ectoparasite) - flea, Lethargy (see also Central nervous system depression in 'Neurological'), La… (Official, 2026-04-26)
  • side_effects: Top reported reactions (openFDA): Vomiting, Lack of efficacy (ectoparasite) - flea, Lethargy (see also Central nervous system depression in 'Neurological'), La… (Official, 2026-04-25)
  • side_effects: Top reported reactions (openFDA): Vomiting, Lack of efficacy (ectoparasite) - flea, Lethargy (see also Central nervous system depression in 'Neurological'), La… (Official, 2026-04-22)
  • side_effects: Top reported reactions (openFDA): Vomiting, Lack of efficacy (ectoparasite) - flea, Lethargy (see also Central nervous system depression in 'Neurological'), La… (Official, 2026-02-12)
Recent Revisions
  • side_effects updated 2026-05-05 10:05 by etl_backfill • Backfilled from existing medication fields
  • side_effects updated 2026-05-03 10:05 by etl_backfill • Backfilled from existing medication fields
  • side_effects updated 2026-04-30 10:09 by etl_backfill • Backfilled from existing medication fields
  • side_effects updated 2026-04-29 10:05 by etl_backfill • Backfilled from existing medication fields
  • side_effects updated 2026-04-28 10:05 by etl_backfill • Backfilled from existing medication fields
  • side_effects updated 2026-04-27 10:05 by etl_backfill • Backfilled from existing medication fields
  • side_effects updated 2026-04-26 10:06 by etl_backfill • Backfilled from existing medication fields
  • side_effects updated 2026-04-25 10:05 by etl_backfill • Backfilled from existing medication fields
  • side_effects updated 2026-04-22 10:07 by etl_backfill • Backfilled from existing medication fields
  • side_effects updated 2026-04-15 10:04 by etl_backfill • Backfilled from existing medication fields
  • side_effects updated 2026-04-11 10:05 by etl_backfill • Backfilled from existing medication fields
  • side_effects updated 2026-02-12 22:44 by etl_backfill • Backfilled from existing medication fields

Top Reported Reactions (openFDA)

De-duplicated reaction terms grouped by body system from FDA openFDA reports (not verified; does not prove causation).

Digestive
Vomiting • Dog Loss of appetite • Dog Drooling • Dog

Showing top 5 for Digestive.

Skin & allergy
Localised hair loss (1) • Cat Itching (1) • Dog

Showing top 5 for Skin & allergy.

Neurologic
Tremors (1) • Dog Tiredness (lethargy) • Dog Seizure NOS • Dog

Showing top 5 for Neurologic.

Behavior
Behavioral disorder • Dog

Showing top 5 for Behavior.

Effectiveness
Lack of efficacy (ectoparasite) - flea (1) • Cat Lack of efficacy • Dog

Showing top 5 for Effectiveness.

Other
Skin lesion NOS (1) • Dog Shaking (1) • Dog Musculoskeletal disorder NOS (1) • Dog Hair change (1) • Dog Disorientation (1) • Dog
Show more (4)
Unable to stand • Dog Skin disorders NOS • Dog Paddling • Dog Lateral recumbency • Dog

Showing top 5 for Other.

Data source: FDA openFDA Animal & Veterinary adverse event reports.

Adverse Event Case Summaries (openFDA)

These are individual FDA adverse event reports. They are unverified and do not prove the medication caused the reaction.

Cat, Mixed (Cat), Mixed, 7 year, 7.257 kilogram • Drug: MSK, Topical, Dose: 1 dose per animal, Frequency: 1 per month • Reactions: Lack of efficacy (ectoparasite) - flea • Outcome: Outcome Unknown

  • Report ID: USA-USFDACVM-2025-US-063326
  • Serious AE: No
  • Treated For AE: Yes
  • Sex: Mixed
  • Age: 7.00 Year
  • Weight: 7.257 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Topical
  • Dose: 1 dose per animal
  • Frequency: 1 per month
Reactions Reported:
Lack of efficacy (ectoparasite) - flea
Outcomes: Outcome Unknown

Data source: FDA openFDA Animal & Veterinary adverse event reports.

Overdose Information

No approved overdose-management text is linked yet. If overdose is suspected, contact a veterinarian or emergency clinic immediately.

Storage & Handling

No approved storage guidance is linked yet for this ingredient. Use manufacturer packaging and veterinary guidance for handling/storage.

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This medication has not been reviewed by a veterinarian yet.