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Roxee Medication Guide

Fipronil 10%/S Methoprene 9% Spot On

Medication reference facts with explicit FDA-approval, off-label, source-limited, and safety context. Roxee does not sell, prescribe, or dispense medications.

Both Source review pending Source coverage pending Owner quick guide first
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Veterinary professional?

Showing simplified owner view. Switch to Vet View for full technical detail.

Data freshness

Reference facts
Source review pending
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Roxee is still reviewing source support for this medication profile.

FDA applications
Regulatory match pending
No refresh timestamp yet

Roxee has safety or ingredient evidence for this medication, but a regulatory product/application match is still pending.

Safety reports
Safety data refreshed
Apr 27, 2026, 10:02 a.m.

openFDA reaction terms and case summaries are supporting evidence, not proof of causality.

Source timing details
Source timing details
  • Reference facts: Source Roxee | Refreshed Jun 22, 2026, 10:45 AM UTC
    The reference fact projection used for browse cards and quick facts.
  • openFDA reaction terms: Source FDA openFDA | Refreshed Jun 22, 2026, 10:45 AM UTC
  • openFDA case summaries: Source FDA openFDA | Refreshed Jun 22, 2026, 10:45 AM UTC
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Fipronil 10%/S Methoprene 9% Spot On

Fipronil 10%/S Methoprene 9% Spot On

Drug type: Generic ingredient • Generic profile • Source coverage pending

Both 58% reference complete

Species: Both

Approval status: Source coverage pending. Roxee has limited supporting content for this record, but no on-page official FDA animal-drug document is linked yet. Treat it as source-limited until the ETL backfill adds official coverage.

Medication Snapshot

Merged from the current Roxee medication system with field-level provenance, freshness, and completeness tracking.

Fipronil 10%/S Methoprene 9% Spot On

Generic name
Fipronil 10%/S Methoprene 9% Spot On
Species
Both
Completeness
58%
Validation
Incomplete

Side Effects

Top reported reactions (openFDA): Vomiting, Lack of efficacy (ectoparasite) - flea, Lethargy (see also Central nervous system depression in 'Neurological'), Lack of efficacy (flea), Skin disorders NOS, Seizure NOS.

FAQ

Both

Source Transparency

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Pet Owner Quick Guide

Start here first for the safest next-step summary before the deeper medication detail.

Roxee still has limited plain-language guidance for this medication. Use the official documents and your veterinarian's instructions for product-specific details.

Used for:

Your vet decides this. Here's what owners typically ask/watch for.

Dosing note:

Exact dosing depends on your pet's species, weight, and health status. Use your veterinarian's instructions for the exact dose and schedule.

What to watch for:

  • Tremors (1 reports)
  • Musculoskeletal disorder NOS (1 reports)
  • Disorientation (1 reports)

When to call the vet:

  • Repeated vomiting or diarrhea.
  • Severe lethargy (hard to wake, very low energy).
  • Collapse or fainting.
  • Trouble breathing.
  • Facial swelling or hives.
  • Blood in vomit or stool.

What to tell or ask your vet today:

  • Is this medicine the right fit for my pet’s current symptoms?
  • Which warning signs mean I should call back right away?
  • How should I handle missed doses or refusal to take the medicine?

Next actions

Talk to a Vet / Find a Vet Near You Save to pet meds Share page Review report evidence
Research brief

Medication Research Insights

A source-aware map of what to know, what is uncertain, and what to verify with your veterinarian.

Source Backed Signals

What to know

Evidence-backed context Limited

Roxee has limited cited overview evidence for Fipronil 10%/S Methoprene 9% Spot On; use the official documents and your veterinarian's instructions for product-specific decisions.

Source: openFDA case USA-USFDACVM-2025-US-029055
Safety signal coverage Reported signals

20 tracked reaction signals; 9 reported cases; 3 serious reports; 2 species groups. These are reporting and label-derived signals for interpretation with a veterinarian.

Source: openFDA case USA-USFDACVM-2025-US-029055
Interpretation guardrail Not causation

Adverse-event reports help form a watch list, but they do not prove the medication caused the reaction and they are not a risk ranking between medications.

Evidence tension

Stronger signal Label / review

Official labels, package inserts, and reviewed summaries carry more weight than isolated reports.

Source: openFDA case USA-USFDACVM-2025-US-029055
Weaker signal Reported data

Case reports and openFDA terms are useful for pattern awareness, but they are incomplete, can include multiple exposures, and do not estimate an individual pet's probability of harm.

Reaction signal map

Most reported reactions Top terms

Tremors (1 reports), Musculoskeletal disorder NOS (1 reports), Disorientation (1 reports), Skin lesion NOS (1 reports), Shaking (1 reports)

Body systems represented Signal grouping

Digestive (3), Skin & allergy (2), Neurologic (3), Behavior (1)

Explore supporting adverse reports

Species and breed lens

Species represented in reports Species lens

Dog (18 reports), Cat (2 reports)

Breed metadata in reports Metadata only

Mixed (Cat) (1). These are report metadata, not proof that a breed is at higher risk.

What your vet may verify

Fit for this patient Vet check

Verify whether Fipronil 10%/S Methoprene 9% Spot On fits the pet's species, current diagnosis, age, weight, organ status, pregnancy/lactation status, and concurrent medications.

Evidence limitations Evidence review

Separate label-backed warnings from adverse-event reports and owner observations before changing the plan.

What to watch next

Watch list Owner-safe

Tremors, Musculoskeletal disorder NOS, Disorientation

Call sooner if Escalation

Repeated vomiting or diarrhea. Severe lethargy (hard to wake, very low energy). Collapse or fainting.

Bottom line: Use this Fipronil 10%/S Methoprene 9% Spot On brief as a structured watch list and source map, not as a reason to start, stop, or change treatment without your veterinarian.
Vet source depth
  1. openFDA case USA-USFDACVM-2025-US-029055 · adverse_reaction · adverse reactions

Evidence

Review status / Updated / Sources

Review status: Clinical reviewer not listed

Updated: April 22, 2026, 10:07 AM UTC

Sources:
Safety & side effects

Side effects to monitor:

  • Tremors
  • Musculoskeletal disorder NOS
  • Disorientation

Most reported reactions:

  • Tremors (1 reports)
  • Musculoskeletal disorder NOS (1 reports)
  • Disorientation (1 reports)
Explore reported case details

Emergency warning signs:

  • Repeated vomiting or diarrhea.
  • Severe lethargy (hard to wake, very low energy).
  • Collapse or fainting.
  • Trouble breathing.
Talk to a Vet / Find a Vet Near You Start Symptom Intake

Vet Fast Scan

Source-backed clinical checkpoints for quick review.

FDA-labeled species
Not linked yet
Indication / use
Your vet decides this. Here's what owners typically ask/watch for.
Form / route / dose
Confirm product label and patient-specific plan.
Warnings
No structured warnings linked yet.
Adverse-event caveat
openFDA adverse-event cases are reported signals. They are not verified, do not prove causation, and do not estimate a pet's individual risk.
Source docs
No source documents linked yet.

Quick Facts

Official label facts first, then secondary summaries. Marketing content is separated below.

Species: Both
Manufacturer: Manufacturer not confirmed

Adverse Reactions

Snapshot first, detailed rows second. This section summarizes signal data and is not a diagnosis.

Reported case explorer

Filter stored openFDA reports by pet and report attributes. Counts describe reports in this data set, not risk.

Clear filters
openFDA adverse-event cases are reported signals. They are not verified, do not prove causation, and do not estimate a pet's individual risk.
Stored reports
1
Matching reports
1
Active filters
1
Selected filters
Body system: Effectiveness Clear
Reset
Drill into common report signals
Lack of efficacy (ectoparasite) - flea (1) Effectiveness (1)
Showing up to 50 matching reports.

USA-USFDACVM-2025-US-063326

Received 2025-10-29 · MSK · MSK

Non-serious
Species
Cat
Breed
Mixed (Cat)
Size / weight
10-24 lb (7.257 Kilogram)
Age
4-7 years (7 Year)
Sex
Mixed Neutered
Region
USA
Reactions
Lack of efficacy (ectoparasite) - flea
Body systems
Effectiveness
Outcomes
Outcome Unknown

Tap or hover a reaction to see what it means in plain language.

Tracked signals
20
Reported cases
9
Serious reports
3
Species represented
2
Grouped by Body System
Digestive (3) · Vomiting, Loss of appetite, Drooling Skin & allergy (2) · Localised hair loss, Itching Neurologic (3) · Tremors, Seizure NOS, Lethargy (see also Central nervous system depression in 'Neurological') Behavior (1) · Behavioral disorder (unspecified) Effectiveness (2) · Lack of efficacy (ectoparasite) - flea, Lack of efficacy (flea) Other (9) · Skin lesion NOS, Shaking, Musculoskeletal disorder NOS
Most Reported Reactions
Reaction Body system Cases Species Serious cases
Neurologic 1 Dog 1
Other 1 Dog 1
Other 1 Dog 1
Other 1 Dog 0
Other 1 Dog 0
Skin & allergy 1 Cat 0
Effectiveness 1 Cat 0
Skin & allergy 1 Dog 0

Species coverage: Dog (18) Cat (2)

View detailed reaction table
Reaction Body system Species Seriousness Frequency Reports
Neurologic Dog Serious - 1
Other Dog Non-serious - 1
Other Dog Non-serious - 1
Other Dog Serious - 1
Skin & allergy Cat Non-serious - 1
Effectiveness Cat Non-serious - 1
Skin & allergy Dog Non-serious - 1
Other Dog Non-serious - 1
Other Dog Serious - 1
Digestive Dog Unknown - -
Other Dog Unknown - -
Other Dog Unknown - -
Neurologic Dog Unknown - -
Other Dog Unknown - -
Digestive Dog Unknown - -
Neurologic Dog Unknown - -
Other Dog Unknown - -
Effectiveness Dog Unknown - -
Digestive Dog Unknown - -
Behavior Dog Unknown - -
Source metadata:
Veterinary reference (advanced)

Canonical medication sections are above. This legacy block remains available for deeper cross-reference without cluttering the primary workflow.

At a Glance

Quick facts and links to official labeling and safety signals.

Data freshness
  • Reference facts: Source Roxee | Refreshed Jun 22, 2026, 10:45 AM UTC
    The reference fact projection used for browse cards and quick facts.
  • openFDA reaction terms: Source FDA openFDA | Refreshed Jun 22, 2026, 10:45 AM UTC
  • openFDA case summaries: Source FDA openFDA | Refreshed Jun 22, 2026, 10:45 AM UTC
Official (FDA)
Identity: Generic ingredient • No FDA branded products linked
No official FDA brand rows linked yet for this ingredient.
Case-reported brands (openFDA): MSK
Catalog species: Both
Safety (openFDA)
Top reactions: Dog 0 • Cat 1 • View
Case summaries: 1 (showing 1) • View
openFDA reports are unverified and do not prove causation.
Diagnosis Codes

Diagnosis-code mappings are not available for this medication yet.

Counseling and Monitoring Highlights

Global Pet owner/Vet mode is controlled in the header. This section avoids duplicate in-page persona tabs.

Top reaction signals
Tremors (1) Musculoskeletal disorder NOS (1) Disorientation (1) Skin lesion NOS (1) Shaking (1) Localised hair loss (1) Lack of efficacy (ectoparasite) - flea (1) Itching (1)

Data Sources & Change Log

Every non-trivial field is expected to include provenance and update timestamps.

Official 61 Clinical 2 Manufacturer 0 Marketing 0
Current Field Facts
  • side_effects: Top reported reactions (openFDA): Vomiting, Lack of efficacy (ectoparasite) - flea, Lethargy (see also Central nervous system depression in 'Neurological'), La… (Clinical, 2026-04-15)
  • side_effects: Top reported reactions (openFDA): Vomiting, Lack of efficacy (ectoparasite) - flea, Lethargy (see also Central nervous system depression in 'Neurological'), La… (Clinical, 2026-04-11)
  • side_effects: Top reported reactions (openFDA): Vomiting, Lack of efficacy (ectoparasite) - flea, Lethargy (see also Central nervous system depression in 'Neurological'), La… (Official, 2026-06-22)
  • side_effects: Top reported reactions (openFDA): Vomiting, Lack of efficacy (ectoparasite) - flea, Lethargy (see also Central nervous system depression in 'Neurological'), La… (Official, 2026-06-22)
  • side_effects: Top reported reactions (openFDA): Vomiting, Lack of efficacy (ectoparasite) - flea, Lethargy (see also Central nervous system depression in 'Neurological'), La… (Official, 2026-06-21)
  • side_effects: Top reported reactions (openFDA): Vomiting, Lack of efficacy (ectoparasite) - flea, Lethargy (see also Central nervous system depression in 'Neurological'), La… (Official, 2026-06-20)
  • side_effects: Top reported reactions (openFDA): Vomiting, Lack of efficacy (ectoparasite) - flea, Lethargy (see also Central nervous system depression in 'Neurological'), La… (Official, 2026-06-13)
  • side_effects: Top reported reactions (openFDA): Vomiting, Lack of efficacy (ectoparasite) - flea, Lethargy (see also Central nervous system depression in 'Neurological'), La… (Official, 2026-06-12)
  • side_effects: Top reported reactions (openFDA): Vomiting, Lack of efficacy (ectoparasite) - flea, Lethargy (see also Central nervous system depression in 'Neurological'), La… (Official, 2026-06-12)
  • side_effects: Top reported reactions (openFDA): Vomiting, Lack of efficacy (ectoparasite) - flea, Lethargy (see also Central nervous system depression in 'Neurological'), La… (Official, 2026-06-11)
  • side_effects: Top reported reactions (openFDA): Vomiting, Lack of efficacy (ectoparasite) - flea, Lethargy (see also Central nervous system depression in 'Neurological'), La… (Official, 2026-06-11)
  • side_effects: Top reported reactions (openFDA): Vomiting, Lack of efficacy (ectoparasite) - flea, Lethargy (see also Central nervous system depression in 'Neurological'), La… (Official, 2026-06-10)
  • side_effects: Top reported reactions (openFDA): Vomiting, Lack of efficacy (ectoparasite) - flea, Lethargy (see also Central nervous system depression in 'Neurological'), La… (Official, 2026-06-08)
  • side_effects: Top reported reactions (openFDA): Vomiting, Lack of efficacy (ectoparasite) - flea, Lethargy (see also Central nervous system depression in 'Neurological'), La… (Official, 2026-06-07)
  • side_effects: Top reported reactions (openFDA): Vomiting, Lack of efficacy (ectoparasite) - flea, Lethargy (see also Central nervous system depression in 'Neurological'), La… (Official, 2026-06-06)
  • side_effects: Top reported reactions (openFDA): Vomiting, Lack of efficacy (ectoparasite) - flea, Lethargy (see also Central nervous system depression in 'Neurological'), La… (Official, 2026-06-05)
  • side_effects: Top reported reactions (openFDA): Vomiting, Lack of efficacy (ectoparasite) - flea, Lethargy (see also Central nervous system depression in 'Neurological'), La… (Official, 2026-06-04)
  • side_effects: Top reported reactions (openFDA): Vomiting, Lack of efficacy (ectoparasite) - flea, Lethargy (see also Central nervous system depression in 'Neurological'), La… (Official, 2026-06-03)
  • side_effects: Top reported reactions (openFDA): Vomiting, Lack of efficacy (ectoparasite) - flea, Lethargy (see also Central nervous system depression in 'Neurological'), La… (Official, 2026-06-02)
  • side_effects: Top reported reactions (openFDA): Vomiting, Lack of efficacy (ectoparasite) - flea, Lethargy (see also Central nervous system depression in 'Neurological'), La… (Official, 2026-06-01)
Recent Revisions
  • side_effects updated 2026-06-22 10:45 by etl_backfill • Backfilled from existing medication fields
  • side_effects updated 2026-06-22 10:04 by etl_backfill • Backfilled from existing medication fields
  • side_effects updated 2026-06-21 05:18 by etl_backfill • Backfilled from existing medication fields
  • side_effects updated 2026-06-20 20:58 by etl_backfill • Backfilled from existing medication fields
  • side_effects updated 2026-06-13 11:33 by etl_backfill • Backfilled from existing medication fields
  • side_effects updated 2026-06-12 10:42 by etl_backfill • Backfilled from existing medication fields
  • side_effects updated 2026-06-12 10:04 by etl_backfill • Backfilled from existing medication fields
  • side_effects updated 2026-06-11 19:22 by etl_backfill • Backfilled from existing medication fields
  • side_effects updated 2026-06-11 18:40 by etl_backfill • Backfilled from existing medication fields
  • side_effects updated 2026-06-10 10:05 by etl_backfill • Backfilled from existing medication fields
  • side_effects updated 2026-06-08 10:05 by etl_backfill • Backfilled from existing medication fields
  • side_effects updated 2026-06-07 10:05 by etl_backfill • Backfilled from existing medication fields
  • side_effects updated 2026-06-06 10:05 by etl_backfill • Backfilled from existing medication fields
  • side_effects updated 2026-06-05 10:05 by etl_backfill • Backfilled from existing medication fields
  • side_effects updated 2026-06-04 10:05 by etl_backfill • Backfilled from existing medication fields
  • side_effects updated 2026-06-03 10:05 by etl_backfill • Backfilled from existing medication fields
  • side_effects updated 2026-06-02 10:05 by etl_backfill • Backfilled from existing medication fields
  • side_effects updated 2026-06-01 10:40 by etl_backfill • Backfilled from existing medication fields
  • side_effects updated 2026-06-01 10:05 by etl_backfill • Backfilled from existing medication fields
  • side_effects updated 2026-05-31 10:05 by etl_backfill • Backfilled from existing medication fields

Top Reported Reactions (openFDA)

De-duplicated reaction terms grouped by body system from FDA openFDA reports (not verified; does not prove causation).

Digestive
Vomiting • Dog Loss of appetite • Dog Drooling • Dog

Showing top 5 for Digestive.

Skin & allergy
Localised hair loss (1) • Cat Itching (1) • Dog

Showing top 5 for Skin & allergy.

Neurologic
Tremors (1) • Dog Tiredness (lethargy) • Dog Seizure NOS • Dog

Showing top 5 for Neurologic.

Behavior
Behavioral disorder • Dog

Showing top 5 for Behavior.

Effectiveness
Lack of efficacy (ectoparasite) - flea (1) • Cat Lack of efficacy • Dog

Showing top 5 for Effectiveness.

Other
Skin lesion NOS (1) • Dog Shaking (1) • Dog Musculoskeletal disorder NOS (1) • Dog Hair change (1) • Dog Disorientation (1) • Dog
Show more (4)
Unable to stand • Dog Skin disorders NOS • Dog Paddling • Dog Lateral recumbency • Dog

Showing top 5 for Other.

Data source: FDA openFDA Animal & Veterinary adverse event reports.

Adverse Event Case Summaries (openFDA)

These are individual FDA adverse event reports. They are unverified and do not prove the medication caused the reaction.

Cat, Mixed (Cat), Mixed, 7 year, 7.257 kilogram • Drug: MSK, Topical, Dose: 1 dose per animal, Frequency: 1 per month • Reactions: Lack of efficacy (ectoparasite) - flea • Outcome: Outcome Unknown

  • Report ID: USA-USFDACVM-2025-US-063326
  • Serious AE: No
  • Treated For AE: Yes
  • Sex: Mixed
  • Age: 7.00 Year
  • Weight: 7.257 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Topical
  • Dose: 1 dose per animal
  • Frequency: 1 per month
Reactions Reported:
Lack of efficacy (ectoparasite) - flea
Outcomes: Outcome Unknown

Data source: FDA openFDA Animal & Veterinary adverse event reports.

Overdose Information

No approved overdose-management text is linked yet. If overdose is suspected, contact a veterinarian or emergency clinic immediately.

Storage & Handling

No approved storage guidance is linked yet for this ingredient. Use manufacturer packaging and veterinary guidance for handling/storage.

Share Your Thoughts

Let others know your experience or advice regarding this medication.

This medication has not been reviewed by a veterinarian yet.