USA-USFDACVM-2026-US-014204
Received 2026-03-25 · MSK · MSK
- Species
- Dog
- Breed
- Retriever - Labrador
- Sex
- Unknown Unknown
- Region
- USA
- Reactions
- Death
- Body systems
- Other
- Outcomes
- Died
Roxee Medication Guide
Galliprant
Medication reference facts with explicit FDA-approval, off-label, source-limited, and safety context. Roxee does not sell, prescribe, or dispense medications.
Both
Source review pending
Source coverage pending
Owner quick guide first
Veterinary professional?
Showing simplified owner view. Switch to Vet View for full technical detail.
Roxee is still reviewing source support for this medication, so verified profile facts are separated from FDA activity. Manufacturer details are not yet confirmed in reference facts.
Source coverage pending.
Roxee has limited supporting content for this record, but no on-page official FDA animal-drug document is linked yet. Treat it as source-limited until the ETL backfill adds official coverage.
Do not start, stop, or change treatment without your veterinarian.
Data freshness
Reference facts
Source review pending
No refresh timestamp yet
Roxee is still reviewing source support for this medication profile.
FDA applications
Regulatory match pending
No refresh timestamp yet
Roxee has safety or ingredient evidence for this medication, but a regulatory product/application match is still pending.
Safety reports
Safety data refreshed
Aug 6, 2026, 7:49 p.m.
openFDA reaction terms and case summaries are supporting evidence, not proof of causality.
Source timing details
Source timing details
-
Reference facts:
Source Roxee
| Refreshed Jul 22, 2026, 7:08 PM UTC
The reference fact projection used for browse cards and quick facts.
- openFDA reaction terms: Source FDA openFDA | Refreshed Aug 6, 2026, 7:52 PM UTC
- openFDA case summaries: Source FDA openFDA | Refreshed Aug 6, 2026, 7:52 PM UTC
Illustration placeholder
Galliprant
Galliprant
Drug type: Generic ingredient • Generic profile • Source coverage pending
Both
80% reference complete
Species: Both
Approval status: Source coverage pending. Roxee has limited supporting content for this record, but no on-page official FDA animal-drug document is linked yet. Treat it as source-limited until the ETL backfill adds official coverage.
Medication Snapshot
Merged from the current Roxee medication system with field-level provenance, freshness, and completeness tracking.
Galliprant
Senvelgo (velagliflozin oral solution) is approved in cats for control of hyperglycemia associated with diabetes mellitus. Species commonly shown: Both.
Generic name
Galliprant
Species
Both
Completeness
80%
Validation
Incomplete
Indications / Uses
Senvelgo (velagliflozin oral solution) is approved in cats for control of hyperglycemia associated with diabetes mellitus.
Side Effects
Top reported reactions (openFDA): Death by euthanasia, Lethargy (see also Central nervous system depression in Neurological), Diarrhoea, Vomiting, Ataxia, Lack of efficacy - NOS.
FAQ
Both
Source Transparency
- Verified source: https://www.roxee.ai/meds/
- Verified source: https://animaldrugsatfda.fda.gov
- Verified source: https://api.fda.gov/animalandveterinary/event.json
- Last refreshed: Jul 22, 2026, 7:08 p.m.
- Last verified: Apr 15, 2026, 10:04 a.m.
- Validation status: Incomplete
Add to My Pet's Medications
Choose a pet, confirm current or past, and optionally add reminder notes.
Sign in to save this medication to your pet profile.
Sign in to continuePet Owner Quick Guide
Start here first for the safest next-step summary before the deeper medication detail.
Roxee still has limited plain-language guidance for this medication. Use the official documents and your veterinarian's instructions for product-specific details.
Used for:
Your vet decides this. Here's what owners typically ask/watch for.
Dosing note:
Exact dosing depends on your pet's species, weight, and health status. Use your veterinarian's instructions for the exact dose and schedule.
What to watch for:
- Decreased haematocrit (1 reports)
- Decreased appetite (1 reports)
- Death by euthanasia (1 reports)
When to call the vet:
- Repeated vomiting or diarrhea.
- Severe lethargy (hard to wake, very low energy).
- Collapse or fainting.
- Trouble breathing.
- Facial swelling or hives.
- Blood in vomit or stool.
What to tell or ask your vet today:
- Is this medicine the right fit for my pet’s current symptoms?
- Which warning signs mean I should call back right away?
- How should I handle missed doses or refusal to take the medicine?
Research brief
Medication Research Insights
A source-aware map of what to know, what is uncertain, and what to verify with your veterinarian.
What to know
Evidence-backed context
Limited
Roxee has limited cited overview evidence for Galliprant; use the official documents and your veterinarian's instructions for product-specific decisions.
Source: openFDA case USA-USFDACVM-2026-US-013316
Safety signal coverage
Reported signals
32 tracked reaction signals; 32 reported cases; 22 serious reports; 1 species group. These are reporting and label-derived signals for interpretation with a veterinarian.
Source: openFDA case USA-USFDACVM-2026-US-013316
Interpretation guardrail
Not causation
Adverse-event reports help form a watch list, but they do not prove the medication caused the reaction and they are not a risk ranking between medications.
Evidence tension
Stronger signal
Label / review
Official labels, package inserts, and reviewed summaries carry more weight than isolated reports.
Source: openFDA case USA-USFDACVM-2026-US-013316
Weaker signal
Reported data
Case reports and openFDA terms are useful for pattern awareness, but they are incomplete, can include multiple exposures, and do not estimate an individual pet's probability of harm.
Reaction signal map
Most reported reactions
Top terms
Decreased haematocrit (1 reports), Decreased appetite (1 reports), Death by euthanasia (1 reports), Death (1 reports), Corneal ulcer (1 reports)
Body systems represented
Signal grouping
Digestive (3), Neurologic (2), Behavior (2), Other (25)
Species and breed lens
Species represented in reports
Species lens
Dog (32 reports)
Breed metadata in reports
Metadata only
Retriever - Labrador (3), ['Retriever - Labrador', 'Poodle (unspecified)'] (1), Retriever - Golden (1), Setter (unspecified) (1). These are report metadata, not proof that a breed is at higher risk.
What your vet may verify
Fit for this patient
Vet check
Verify whether Galliprant fits the pet's species, current diagnosis, age, weight, organ status, pregnancy/lactation status, and concurrent medications.
Evidence limitations
Evidence review
Separate label-backed warnings from adverse-event reports and owner observations before changing the plan.
What to watch next
Watch list
Owner-safe
Decreased haematocrit, Decreased appetite, Death by euthanasia
Call sooner if
Escalation
Repeated vomiting or diarrhea. Severe lethargy (hard to wake, very low energy). Collapse or fainting.
Bottom line: Use this Galliprant brief as a structured watch list and source map, not as a reason to start, stop, or change treatment without your veterinarian.
Vet source depth
- openFDA case USA-USFDACVM-2026-US-013316 · adverse_reaction · adverse reactions
Evidence
Review status / Updated / Sources
Review status: Clinical reviewer not listed
Updated: April 15, 2026, 10:04 AM UTC
Sources:
- openFDA case USA-USFDACVM-2026-US-013316 · adverse_reaction
Safety & side effects
Side effects to monitor:
- Decreased haematocrit
- Decreased appetite
- Death by euthanasia
Most reported reactions:
- Decreased haematocrit (1 reports)
- Decreased appetite (1 reports)
- Death by euthanasia (1 reports)
Emergency warning signs:
- Repeated vomiting or diarrhea.
- Severe lethargy (hard to wake, very low energy).
- Collapse or fainting.
- Trouble breathing.
Vet Fast Scan
Source-backed clinical checkpoints for quick review.
FDA-labeled species
Not linked yet
Indication / use
Your vet decides this. Here's what owners typically ask/watch for.
Form / route / dose
Confirm product label and patient-specific plan.
Warnings
No structured warnings linked yet.
Adverse-event caveat
openFDA adverse-event cases are reported signals. They are not verified, do not prove causation, and do not estimate a pet's individual risk.
Source docs
No source documents linked yet.
Quick Facts
Official label facts first, then secondary summaries. Marketing content is separated below.
Species: Both
Manufacturer: Manufacturer not confirmed
Adverse Reactions
Snapshot first, detailed rows second. This section summarizes signal data and is not a diagnosis.
Reported case explorer
Filter stored openFDA reports by pet and report attributes. Counts describe reports in this data set, not risk.
openFDA adverse-event cases are reported signals. They are not verified, do not prove causation, and do not estimate a pet's individual risk.
Stored reports
35
Matching reports
31
Active filters
1
Selected filters
Body system: Other
Clear
Drill into common report signals
Showing up to 50 matching reports.
USA-USFDACVM-2026-US-014118
Received 2026-03-24 · MSK · MSK
- Species
- Dog
- Breed
- Retriever - Labrador
- Size / weight
- 50-99 lb (33.11 Kilogram)
- Age
- 8+ years (12 Year)
- Sex
- Female Neutered
- Region
- USA
- Reactions
- ThrombocytopeniaLethargy (see also Central nervous system depression in Neurological)
- Body systems
- OtherNeurologic
- Outcomes
- Outcome Unknown
USA-USFDACVM-2026-US-014065
Received 2026-03-24 · MSK · MSK
- Species
- Dog
- Breed
- Retriever - Golden
- Size / weight
- 50-99 lb (34.019 Kilogram)
- Age
- 4-7 years (4 Year)
- Sex
- Female Unknown
- Region
- USA
- Reactions
- LamenessDifficulty to riseJoint swellingAbnormal radiograph findingBone and joint disorder NOSDiscomfort NOS
- Body systems
- OtherSkin & allergy
- Outcomes
- Ongoing
USA-USFDACVM-2026-US-013873
Received 2026-03-23 · MSK · MSK
- Species
- Dog
- Breed
- Setter (unspecified)
- Size / weight
- 50-99 lb (27.2 Kilogram)
- Age
- 8+ years (14 Year)
- Sex
- Male Neutered
- Region
- USA
- Reactions
- DeathBreathing difficultyWeight loss
- Body systems
- Other
- Outcomes
- Died
USA-USFDACVM-2026-US-013540
Received 2026-03-23 · MSK · MSK
- Species
- Dog
- Breed
- Terrier (unspecified)
- Size / weight
- 10-24 lb (8.8 Kilogram)
- Age
- 8+ years (12.16 Year)
- Sex
- Female Neutered
- Region
- USA
- Reactions
- Seizure NOSIntentional misuse
- Body systems
- NeurologicOther
- Outcomes
- Recovered/Normal
USA-USFDACVM-2026-US-013521
Received 2026-03-23 · MSK · MSK
- Species
- Dog
- Breed
- American Pit Bull Terrier
- Size / weight
- 50-99 lb (34.47 Kilogram)
- Age
- 8+ years (13 Year)
- Sex
- Female Neutered
- Region
- USA
- Reactions
- TremblingPantingMedication error NOS
- Body systems
- Other
- Outcomes
- Recovered/Normal
USA-USFDACVM-2026-US-013503
Received 2026-03-23 · MSK · MSK
- Species
- Dog
- Breed
- Retriever - Labrador
- Size / weight
- 50-99 lb (35.017 Kilogram)
- Age
- 8+ years (15 Year)
- Sex
- Male Neutered
- Region
- USA
- Reactions
- Unable to standMusculoskeletal disorder NOSWeaknessNot eatingLethargy (see also Central nervous system depression in Neurological)Proprioception deficitWeight lossTarry or black stool (see also haemorrhagic diarrhoea)
- Body systems
- OtherNeurologicDigestive
- Outcomes
- Ongoing
USA-USFDACVM-2026-US-013316
Received 2026-03-16 · MSK · MSK
- Species
- Dog
- Breed
- ['Shepherd Dog - German', 'Dog (unknown)']
- Size / weight
- 50-99 lb (31.842 Kilogram)
- Age
- 8+ years (13 Year)
- Sex
- Male Neutered
- Region
- USA
- Reactions
- Emesis (multiple)Reluctant to moveUnable to riseDifficulty to riseWeaknessNot eatingNot drinkingHeavy breathingPantingLethargy (see also Central nervous system depression in Neurological)Increased heart rateIncreased respiratory rateAbdominal discomfortDehydrationLeukocytosis NOSMonocytosisAbnormal ultrasound finding
- Body systems
- DigestiveOtherNeurologic
- Outcomes
- Ongoing
USA-USFDACVM-2026-US-012589
Received 2026-03-16 · MSK · MSK
- Species
- Dog
- Breed
- Siberian Husky
- Size / weight
- 50-99 lb (28.576 Kilogram)
- Age
- 8+ years (15 Year)
- Sex
- Male Neutered
- Region
- USA
- Reactions
- Death by euthanasiaElevated symmetrical dimethylarginine (SDMA)Reluctant to movePolyuria
- Body systems
- Other
- Outcomes
- Euthanized
USA-USFDACVM-2026-US-012478
Received 2026-03-16 · MSK · MSK
- Species
- Dog
- Breed
- ['Retriever - Labrador', 'Terrier - Bull - American Pit']
- Size / weight
- 50-99 lb (31.298 Kilogram)
- Age
- 8+ years (14 Year)
- Sex
- Female Neutered
- Region
- USA
- Reactions
- Limb weaknessDecreased appetiteDeath by euthanasiaLethargy (see also Central nervous system depression in Neurological)Panting
- Body systems
- OtherDigestiveNeurologic
- Outcomes
- Euthanized
USA-USFDACVM-2026-US-012312
Received 2026-03-16 · MSK · MSK
- Species
- Dog
- Breed
- Terrier - Norfolk
- Size / weight
- 25-49 lb (12 Kilogram)
- Age
- 8+ years (12 Year)
- Sex
- Male Neutered
- Region
- USA
- Reactions
- Weight gain
- Body systems
- Other
- Outcomes
- Outcome Unknown
USA-USFDACVM-2026-US-012110
Received 2026-03-16 · MSK · MSK
- Species
- Dog
- Breed
- Shar Pei
- Size / weight
- 50-99 lb (32.7 Kilogram)
- Age
- 8+ years (11 Year)
- Sex
- Female Neutered
- Region
- USA
- Reactions
- ArthritisDecreased appetiteHigh sodium-potassium ratio (Na:K ratio)VomitingDiarrhoeaGait abnormalityAppetite disorder NOSStiffness NOSNot defecatingWeight lossDysorexiaHair loss NOSWeaknessMuscle wastingDistension of abdomenPolyuriaDehydrationShakingShiveringTremorGreasy skinHair sheddingAnxiety
- Body systems
- OtherDigestiveSkin & allergyNeurologicBehavior
- Outcomes
- Recovered/Normal
USA-USFDACVM-2026-US-012098
Received 2026-03-16 · MSK · MSK
- Species
- Dog
- Breed
- Retriever - Labrador
- Size / weight
- 50-99 lb (23.088 Kilogram)
- Age
- 8+ years (13 Year)
- Sex
- Male Neutered
- Region
- USA
- Reactions
- AtaxiaGeneralised weaknessProprioception deficit
- Body systems
- NeurologicOther
- Outcomes
- Ongoing
USA-USFDACVM-2026-US-008246
Received 2026-02-24 · MSK · MSK
- Species
- Dog
- Breed
- Retriever - Labrador
- Size / weight
- 100+ lb (48.08 Kilogram)
- Age
- 4-7 years (7.5 Year)
- Sex
- Male Neutered
- Region
- USA
- Reactions
- Death by euthanasiaNot himself/herselfLethargy (see also Central nervous system depression in Neurological)VomitingHaemorrhage NOSWeight lossSternoabdominal recumbencyDehydrationDiabetic ketoacidosisAcute pancreatitisAzotaemia
- Body systems
- OtherNeurologicDigestive
- Outcomes
- Euthanized
USA-USFDACVM-2026-US-006945
Received 2026-02-04 · MSK · MSK
- Species
- Dog
- Breed
- Crossbred Canine/dog
- Size / weight
- 25-49 lb (20.41 Kilogram)
- Age
- 8+ years (14 Year)
- Sex
- Female Neutered
- Region
- USA
- Reactions
- Elevated alanine aminotransferase (ALT)Tooth disorder
- Body systems
- Other
- Outcomes
- Ongoing
USA-USFDACVM-2026-US-005467
Received 2026-01-27 · MSK · MSK
- Species
- Dog
- Breed
- ['Retriever - Labrador', 'Dog (unknown)']
- Age
- 8+ years (11 Year)
- Sex
- Female Neutered
- Region
- USA
- Reactions
- VocalisationInjection site painIncreased skin sensitivityInjection site inflammationInjection site reddeningLeukocytosis NOSNeutrophiliaMonocytosisEosinopeniaThrombocytosisHyperkalaemiaLow sodium-potassium ratio (Na:K ratio)Elevated creatine-kinase (CK)Low thyroxine (T4)Abnormal cytologyPanniculitisAbnormal radiograph findingSleep disturbance NOSNecrotic woundInjection site oedemaInjection site haemorrhageDehiscenceBacterial skin infection NOSInjection site mass NOS
- Body systems
- Other
- Outcomes
- Ongoing
USA-USFDACVM-2026-US-002245
Received 2026-01-19 · MSK · MSK
- Species
- Dog
- Breed
- Dachshund (unspecified)
- Size / weight
- 10-24 lb (4.554 Kilogram)
- Age
- 1-3 years (1.5 Year)
- Sex
- Female Neutered
- Region
- USA
- Reactions
- Unsteady gaitIncreased skin sensitivityDazedElevated temperatureDecreased heart rateDilated pupils
- Body systems
- Other
- Outcomes
- Outcome Unknown
USA-USFDACVM-2025-US-075044
Received 2025-12-23 · MSK · MSK
- Species
- Dog
- Breed
- Siberian Husky
- Size / weight
- 50-99 lb (26.58 Kilogram)
- Age
- 8+ years (11 Year)
- Sex
- Female Neutered
- Region
- USA
- Reactions
- Clonic seizureBiting -aggression (see also Skin and appendages disorders)Partial blindnessSeizure NOSFoaming at the mouthOral bleedingLethargy (see also Central nervous system depression in Neurological)WobblinessUnable to focusUrinationLateral recumbencyVocalisationBalance problemStaringElevated alanine aminotransferase (ALT)Elevated serum alkaline phosphatase (ALP)
- Body systems
- NeurologicBehaviorOther
- Outcomes
- Ongoing
USA-USFDACVM-2025-US-074815
Received 2025-12-23 · MSK · MSK
- Species
- Dog
- Breed
- Dog (unknown)
- Sex
- Unknown Unknown
- Region
- USA
- Reactions
- Spinal pain NOSPainful defecationNot eatingNot drinking
- Body systems
- Other
- Outcomes
- Ongoing
USA-USFDACVM-2025-US-075413
Received 2025-12-19 · MSK · MSK
- Species
- Dog
- Breed
- Crossbred Canine/dog
- Size / weight
- 50-99 lb (30.119 Kilogram)
- Age
- 8+ years (12 Year)
- Sex
- Male Neutered
- Region
- USA
- Reactions
- Not eatingVomitingLymphadenopathyHalitosisLow platelet countElevated alanine aminotransferase (ALT)Elevated serum alkaline phosphatase (ALP)Anxiety
- Body systems
- OtherDigestiveBehavior
- Outcomes
- Ongoing
USA-USFDACVM-2025-US-074700
Received 2025-12-19 · MSK · MSK
- Species
- Dog
- Breed
- Shepherd Dog - German
- Size / weight
- 50-99 lb (35.38 Kilogram)
- Age
- 8+ years (12 Year)
- Sex
- Male Unknown
- Region
- USA
- Reactions
- Increased appetiteFlatulence
- Body systems
- DigestiveOther
- Outcomes
- Outcome Unknown
USA-USFDACVM-2025-US-074697
Received 2025-12-19 · MSK · MSK
- Species
- Dog
- Breed
- Retriever - Labrador
- Size / weight
- 50-99 lb (30.5 Kilogram)
- Age
- 8+ years (11.08 Year)
- Sex
- Male Intact
- Region
- USA
- Reactions
- Ear infection NOSAnorexiaNauseaVomitingPolycythaemiaElevated haemoglobinIncreased percentage reticulocytesElevated mean corpuscular volume (MCV)Elevated alanine aminotransferase (ALT)Elevated serum alkaline phosphatase (ALP)Elevated gamma-glutamyl transferase (GGT)Elevated cholesterol (total)HyperproteinaemiaElevated total bilirubinElevated blood urea nitrogen (BUN)Abnormal ultrasound findingAbnormal histology NOSOther abnormal test result NOS
- Body systems
- OtherDigestive
- Outcomes
- Ongoing
USA-USFDACVM-2025-US-074497
Received 2025-12-19 · MSK · MSK
- Species
- Dog
- Breed
- ['Terrier - Scottish', 'Dog (unknown)']
- Size / weight
- 10-24 lb (11.249 Kilogram)
- Age
- 8+ years (16 Year)
- Sex
- Male Neutered
- Region
- USA
- Reactions
- RestlessnessStaringConfusionDifficulty eating NOSAnxietyElevated blood urea nitrogen (BUN)Elevated serum alkaline phosphatase (ALP)
- Body systems
- OtherBehavior
- Outcomes
- Ongoing
USA-USFDACVM-2025-US-074272
Received 2025-12-18 · MSK · MSK
- Species
- Dog
- Breed
- ['Terrier (unspecified)', 'Dog (unknown)']
- Size / weight
- 10-24 lb (9.072 Kilogram)
- Age
- 8+ years (14 Year)
- Sex
- Male Intact
- Region
- USA
- Reactions
- DeathSeizure NOSRenal failureAnaemia NOSAnorexiaSleepiness - systemic disorderConfusionShakingUnable to riseBumping into wallsCorneal ulcerIncreased drinkingSquintingOcular dischargeBiting -aggression (see also Skin and appendages disorders)Elevated alanine aminotransferase (ALT)Medication error NOSGeneral illness
- Body systems
- OtherNeurologicDigestiveBehavior
- Outcomes
- Died
USA-USFDACVM-2025-US-074601
Received 2025-12-16 · MSK · MSK
- Species
- Dog
- Breed
- Retriever - Labrador
- Size / weight
- 50-99 lb (39.463 Kilogram)
- Age
- 4-7 years (5 Year)
- Sex
- Male Neutered
- Region
- USA
- Reactions
- Limb non-weight bearingBone and joint disorder NOSOther abnormal test result NOSAbnormal radiograph findingUrinary tract obstruction/blockageDiscomfort NOSWalking difficultyDeath by euthanasiaOsteochondritis dissecansUrolithiasis
- Body systems
- Other
- Outcomes
- Euthanized
USA-USFDACVM-2025-US-073622
Received 2025-12-11 · MSK · MSK
- Species
- Dog
- Breed
- Collie - Border
- Size / weight
- 25-49 lb (17.23 Kilogram)
- Age
- 8+ years (11 Year)
- Sex
- Female Neutered
- Region
- USA
- Reactions
- GaggingDroolingArthritisUNPALATABLEMedication error NOSINEFFECTIVE, OTHER DRUG(S)
- Body systems
- OtherDigestive
- Outcomes
- Outcome Unknown
USA-USFDACVM-2025-US-074653
Received 2025-12-09 · MSK · MSK
- Species
- Dog
- Breed
- ['Pit Bull', 'Dog (unknown)']
- Size / weight
- 50-99 lb (37.376 Kilogram)
- Age
- 8+ years (11.5 Year)
- Sex
- Female Neutered
- Region
- USA
- Reactions
- Joint swellingBone and joint disorder NOSSarcoma NOS
- Body systems
- Skin & allergyOther
- Outcomes
- Ongoing
USA-USFDACVM-2025-US-072652
Received 2025-12-08 · MSK · MSK
- Species
- Dog
- Breed
- ['Retriever - Labrador', 'Dog (unknown)']
- Age
- 8+ years (11 Year)
- Sex
- Female Unknown
- Region
- USA
- Reactions
- VocalisationInjection site painIncreased skin sensitivityInjection site inflammationInjection site reddeningLeucocytosis NOSNeutrophiliaMonocytosisEosinopeniaThrombocytosisHyperkalaemiaLow sodium-potassium ratio (Na:K ratio)Elevated creatine-kinase (CK)Low thyroxine (T4)Abnormal cytologyPanniculitisAbnormal radiograph findingSleep disturbance NOSNecrotic woundInjection site oedemaInjection site haemorrhageDehiscenceBacterial skin infection NOSInjection site mass NOS
- Body systems
- Other
- Outcomes
- Ongoing
USA-USFDACVM-2025-US-072463
Received 2025-12-01 · MSK · MSK
- Species
- Dog
- Breed
- ['Rottweiler', 'Retriever - Labrador']
- Size / weight
- 50-99 lb (27.76 Kilogram)
- Age
- 8+ years (14 Year)
- Sex
- Male Neutered
- Region
- USA
- Reactions
- Proprioception deficitMusculoskeletal disorder NOSLethargy (see also Central nervous system depression in Neurological)AnorexiaReluctant to moveBradycardiaArrhythmiaPyrexiaLymphocytosisLeucocytosis NOSLow thyroxine (T4)Elevated symmetrical dimethylarginine (SDMA)Urinary tract infection
- Body systems
- OtherNeurologicDigestive
- Outcomes
- Ongoing
USA-USFDACVM-2025-US-072107
Received 2025-12-01 · MSK · MSK
- Species
- Dog
- Breed
- Shepherd Dog - German
- Size / weight
- 50-99 lb (40.1 Kilogram)
- Age
- 8+ years (10.5 Year)
- Sex
- Male Neutered
- Region
- USA
- Reactions
- VocalisationAbnormal tail posturePain NOSWeight lossDecreased appetiteVomitingChewing disorderPantingTremblingLying downAnxietyExcessive chewing, licking and/or groomingMuscle atrophy (see also Muscle wasting)Musculoskeletal disorder NOSAbnormal radiograph findingSpondylosisJoint effusionElevated gamma-glutamyl transferase (GGT)LymphopeniaLethargy (see also Central nervous system depression in Neurological)Thoracic painDeath by euthanasiaMedication error NOS
- Body systems
- OtherDigestiveBehaviorNeurologic
- Outcomes
- Euthanized
USA-USFDACVM-2025-US-070905
Received 2025-12-01 · MSK · MSK
- Species
- Dog
- Breed
- ['Chihuahua', 'Dog (unknown)']
- Size / weight
- 10-24 lb (6.759 Kilogram)
- Age
- 8+ years (9 Year)
- Sex
- Female Neutered
- Region
- USA
- Reactions
- Heart murmurEosinophiliaHeart valve disorderPulmonary stenosisMusculoskeletal disorder NOSIntestinal thickeningRenal disorder NOSThrombocytosisHypersalivationGlucosuriaNon-regenerative anaemiaRenal insufficiencyIsosthenuriaOther abnormal test result NOSAnaemia NOSHyperkalaemiaHypercalcaemiaHypoalbuminaemia
- Body systems
- OtherDigestive
- Outcomes
- Ongoing
Tap or hover a reaction to see what it means in plain language.
Tracked signals
32
Reported cases
32
Serious reports
22
Species represented
1
Grouped by Body System
Digestive (3)
· Loss of appetite, Decreased appetite, Appetite disorder NOS
Neurologic (2)
· Unsteady walking (ataxia), Clonic seizure
Behavior (2)
· Biting -aggression, Anxiety
Other (25)
· Decreased heart rate, Decreased haematocrit, Death by euthanasia
Most Reported Reactions
| Reaction | Body system | Cases | Species | Serious cases |
|---|---|---|---|---|
| Other | 1 | Dog | 1 | |
| Digestive | 1 | Dog | 1 | |
| Other | 1 | Dog | 1 | |
| Other | 1 | Dog | 1 | |
| Other | 1 | Dog | 1 | |
| Other | 1 | Dog | 1 | |
| Neurologic | 1 | Dog | 1 | |
| Other | 1 | Dog | 1 |
Species coverage: Dog (32)
View detailed reaction table
| Reaction | Body system | Species | Seriousness | Frequency | Reports |
|---|---|---|---|---|---|
| Neurologic | Dog | Non-serious | - | 1 | |
| Digestive | Dog | Non-serious | - | 1 | |
| Other | Dog | Non-serious | - | 1 | |
| Other | Dog | Serious | - | 1 | |
| Digestive | Dog | Serious | - | 1 | |
| Other | Dog | Serious | - | 1 | |
| Other | Dog | Serious | - | 1 | |
| Other | Dog | Non-serious | - | 1 | |
| Other | Dog | Serious | - | 1 | |
| Other | Dog | Serious | - | 1 | |
| Neurologic | Dog | Serious | - | 1 | |
| Other | Dog | Serious | - | 1 | |
| Other | Dog | Serious | - | 1 | |
| Other | Dog | Serious | - | 1 | |
| Other | Dog | Non-serious | - | 1 | |
| Other | Dog | Serious | - | 1 | |
| Behavior | Dog | Serious | - | 1 | |
| Other | Dog | Serious | - | 1 | |
| Other | Dog | Serious | - | 1 | |
| Other | Dog | Serious | - | 1 | |
| Other | Dog | Non-serious | - | 1 | |
| Other | Dog | Non-serious | - | 1 | |
| Digestive | Dog | Non-serious | - | 1 | |
| Behavior | Dog | Serious | - | 1 | |
| Other | Dog | Serious | - | 1 | |
| Other | Dog | Serious | - | 1 | |
| Other | Dog | Non-serious | - | 1 | |
| Other | Dog | Serious | - | 1 | |
| Other | Dog | Serious | - | 1 | |
| Other | Dog | Non-serious | - | 1 | |
| Other | Dog | Serious | - | 1 | |
| Other | Dog | Serious | - | 1 |
Source metadata:
- https://api.fda.gov/animalandveterinary/event.json · adverse_reaction · openFDA case USA-USFDACVM-2026-US-013316
Veterinary reference (advanced)
Canonical medication sections are above. This legacy block remains available for deeper cross-reference without cluttering the primary workflow.
At a Glance
Quick facts and links to official labeling and safety signals.
Data freshness
-
Reference facts:
Source Roxee
| Refreshed Jul 22, 2026, 7:08 PM UTC
The reference fact projection used for browse cards and quick facts.
- openFDA reaction terms: Source FDA openFDA | Refreshed Aug 6, 2026, 7:52 PM UTC
- openFDA case summaries: Source FDA openFDA | Refreshed Aug 6, 2026, 7:52 PM UTC
Official (FDA)
Identity: Generic ingredient
• No FDA branded products linked
No official FDA brand rows linked yet for this ingredient.
Case-reported brands (openFDA):
MSK
Catalog species: Both
Diagnosis Codes
Diagnosis-code mappings are not available for this medication yet.
Counseling and Monitoring Highlights
Global Pet owner/Vet mode is controlled in the header. This section avoids duplicate in-page persona tabs.
Top reaction signals
Decreased haematocrit (1)
Decreased appetite (1)
Death by euthanasia (1)
Death (1)
Corneal ulcer (1)
Confusion (1)
Clonic seizure (1)
Chewing disorder (1)
Data Sources & Change Log
Every non-trivial field is expected to include provenance and update timestamps.
Official 93
Clinical 5
Manufacturer 0
Marketing 0
Current Field Facts
- monitoring: Monitor blood glucose and ketones, hydration status, appetite, and clinical response at regular intervals. (Clinical, 2026-04-21)
- monitoring: Monitor blood glucose and ketones, hydration status, appetite, and clinical response at regular intervals. (Clinical, 2026-04-20)
- monitoring: Monitor blood glucose and ketones, hydration status, appetite, and clinical response at regular intervals. (Clinical, 2026-04-19)
- monitoring: Monitor blood glucose and ketones, hydration status, appetite, and clinical response at regular intervals. (Clinical, 2026-04-16)
- side_effects: Top reported reactions (openFDA): Death by euthanasia, Lethargy (see also Central nervous system depression in Neurological), Diarrhoea, Vomiting, Ataxia, Lack… (Clinical, 2026-04-11)
- side_effects: Top reported reactions (openFDA): Death by euthanasia, Lethargy (see also Central nervous system depression in Neurological), Diarrhoea, Vomiting, Ataxia, Lack… (Official, 2026-07-22)
- side_effects: Top reported reactions (openFDA): Death by euthanasia, Lethargy (see also Central nervous system depression in Neurological), Diarrhoea, Vomiting, Ataxia, Lack… (Official, 2026-07-22)
- side_effects: Top reported reactions (openFDA): Death by euthanasia, Lethargy (see also Central nervous system depression in Neurological), Diarrhoea, Vomiting, Ataxia, Lack… (Official, 2026-07-22)
- side_effects: Top reported reactions (openFDA): Death by euthanasia, Lethargy (see also Central nervous system depression in Neurological), Diarrhoea, Vomiting, Ataxia, Lack… (Official, 2026-07-20)
- side_effects: Top reported reactions (openFDA): Death by euthanasia, Lethargy (see also Central nervous system depression in Neurological), Diarrhoea, Vomiting, Ataxia, Lack… (Official, 2026-07-19)
- side_effects: Top reported reactions (openFDA): Death by euthanasia, Lethargy (see also Central nervous system depression in Neurological), Diarrhoea, Vomiting, Ataxia, Lack… (Official, 2026-07-16)
- side_effects: Top reported reactions (openFDA): Death by euthanasia, Lethargy (see also Central nervous system depression in Neurological), Diarrhoea, Vomiting, Ataxia, Lack… (Official, 2026-07-16)
- side_effects: Top reported reactions (openFDA): Death by euthanasia, Lethargy (see also Central nervous system depression in Neurological), Diarrhoea, Vomiting, Ataxia, Lack… (Official, 2026-07-13)
- side_effects: Top reported reactions (openFDA): Death by euthanasia, Lethargy (see also Central nervous system depression in Neurological), Diarrhoea, Vomiting, Ataxia, Lack… (Official, 2026-07-12)
- side_effects: Top reported reactions (openFDA): Death by euthanasia, Lethargy (see also Central nervous system depression in Neurological), Diarrhoea, Vomiting, Ataxia, Lack… (Official, 2026-07-11)
- side_effects: Top reported reactions (openFDA): Death by euthanasia, Lethargy (see also Central nervous system depression in Neurological), Diarrhoea, Vomiting, Ataxia, Lack… (Official, 2026-07-11)
- side_effects: Top reported reactions (openFDA): Death by euthanasia, Lethargy (see also Central nervous system depression in Neurological), Diarrhoea, Vomiting, Ataxia, Lack… (Official, 2026-07-11)
- side_effects: Top reported reactions (openFDA): Death by euthanasia, Lethargy (see also Central nervous system depression in Neurological), Diarrhoea, Vomiting, Ataxia, Lack… (Official, 2026-07-10)
- side_effects: Top reported reactions (openFDA): Death by euthanasia, Lethargy (see also Central nervous system depression in Neurological), Diarrhoea, Vomiting, Ataxia, Lack… (Official, 2026-07-07)
- side_effects: Top reported reactions (openFDA): Death by euthanasia, Lethargy (see also Central nervous system depression in Neurological), Diarrhoea, Vomiting, Ataxia, Lack… (Official, 2026-07-06)
Recent Revisions
- side_effects updated 2026-07-22 19:08 by etl_backfill • Backfilled from existing medication fields
- side_effects updated 2026-07-22 18:40 by etl_backfill • Backfilled from existing medication fields
- side_effects updated 2026-07-22 08:29 by etl_backfill • Backfilled from existing medication fields
- side_effects updated 2026-07-20 10:05 by etl_backfill • Backfilled from existing medication fields
- side_effects updated 2026-07-19 13:48 by etl_backfill • Backfilled from existing medication fields
- side_effects updated 2026-07-16 16:34 by etl_backfill • Backfilled from existing medication fields
- side_effects updated 2026-07-16 15:43 by etl_backfill • Backfilled from existing medication fields
- side_effects updated 2026-07-13 10:06 by etl_backfill • Backfilled from existing medication fields
- side_effects updated 2026-07-12 17:56 by etl_backfill • Backfilled from existing medication fields
- side_effects updated 2026-07-11 19:04 by etl_backfill • Backfilled from existing medication fields
- side_effects updated 2026-07-11 08:49 by etl_backfill • Backfilled from existing medication fields
- side_effects updated 2026-07-11 08:05 by etl_backfill • Backfilled from existing medication fields
- side_effects updated 2026-07-10 21:24 by etl_backfill • Backfilled from existing medication fields
- side_effects updated 2026-07-07 10:06 by etl_backfill • Backfilled from existing medication fields
- side_effects updated 2026-07-06 20:16 by etl_backfill • Backfilled from existing medication fields
- side_effects updated 2026-07-06 08:13 by etl_backfill • Backfilled from existing medication fields
- side_effects updated 2026-07-03 20:16 by etl_backfill • Backfilled from existing medication fields
- side_effects updated 2026-07-03 11:05 by etl_backfill • Backfilled from existing medication fields
- side_effects updated 2026-07-02 22:45 by etl_backfill • Backfilled from existing medication fields
- side_effects updated 2026-07-01 23:29 by etl_backfill • Backfilled from existing medication fields
Top Reported Reactions (openFDA)
De-duplicated reaction terms grouped by body system from FDA openFDA reports (not verified; does not prove causation).
Digestive
Loss of appetite (1)
• Dog
Decreased appetite (1)
• Dog
Appetite disorder NOS (1)
• Dog
Showing top 5 for Digestive.
Neurologic
Unsteady walking (1)
• Dog
Clonic seizure (1)
• Dog
Showing top 5 for Neurologic.
Behavior
Biting -aggression (1)
• Dog
Anxiety (1)
• Dog
Showing top 5 for Behavior.
Other
Decreased heart rate (1)
• Dog
Decreased haematocrit (1)
• Dog
Death by euthanasia (1)
• Dog
Death (1)
• Dog
Dazed (1)
• Dog
Show more (20)
Corneal ulcer (1)
• Dog
Confusion (1)
• Dog
Chewing disorder (1)
• Dog
Bumping into walls (1)
• Dog
Breathing difficulty (1)
• Dog
Bradycardia (1)
• Dog
Bone and joint disorder NOS (1)
• Dog
Balance problem (1)
• Dog
Bacterial skin infection NOS (1)
• Dog
Azotaemia (1)
• Dog
Arthritis (1)
• Dog
Arrhythmia (1)
• Dog
Anaemia NOS (1)
• Dog
Acute pancreatitis (1)
• Dog
Abnormal ultrasound finding (1)
• Dog
Abnormal tail posture (1)
• Dog
Abnormal radiograph finding (1)
• Dog
Abnormal histology NOS (1)
• Dog
Abnormal cytology (1)
• Dog
Abdominal discomfort (1)
• Dog
Showing top 5 for Other.
Data source: FDA openFDA Animal & Veterinary adverse event reports.
Adverse Event Case Summaries (openFDA)
These are individual FDA adverse event reports. They are unverified and do not prove the medication caused the reaction.
Dog, Retriever - Labrador, Unknown • Drug: MSK, Tablet, Unknown • Reactions: Death • Outcome: Died
- Report ID: USA-USFDACVM-2026-US-014204
- Serious AE: Yes
- Treated For AE: No
- Sex: Unknown
- Case-reported brand: MSK
- Case-reported manufacturer: MSK
- Route: Unknown
- Form: Tablet
Reactions Reported:
Death
Outcomes: Died
Dog, Retriever - Labrador, Female, 12 year, 33.11 kilogram • Drug: MSK, Tablet, Oral, Frequency: 1 per day • Reactions: Thrombocytopenia, Tiredness (lethargy) • Outcome: Outcome Unknown
- Report ID: USA-USFDACVM-2026-US-014118
- Serious AE: No
- Treated For AE: No
- Sex: Female
- Age: 12.00 Year
- Weight: 33.110 Kilogram
- Case-reported brand: MSK
- Case-reported manufacturer: MSK
- Route: Oral
- Form: Tablet
- Frequency: 1 per day
Reactions Reported:
Thrombocytopenia
Tiredness (lethargy)
Outcomes: Outcome Unknown
Dog, ['Retriever - Labrador', 'Poodle (unspecified)'], Female, 16.33 year, 5.897 kilogram • Drug: MSK, Tablet, Oral, Dose: 0.50 tablet per animal • Reactions: Vomiting • Outcome: Recovered/Normal
- Report ID: USA-USFDACVM-2026-US-014113
- Serious AE: No
- Treated For AE: Yes
- Sex: Female
- Age: 16.33 Year
- Weight: 5.897 Kilogram
- Case-reported brand: MSK
- Case-reported manufacturer: MSK
- Route: Oral
- Form: Tablet
- Dose: 0.50 tablet per animal
Reactions Reported:
Vomiting
Outcomes: Recovered/Normal
Dog, Retriever - Golden, Female, 4 year, 34.019 kilogram • Drug: MSK, Unassigned, Unknown, Dose: 75 Milligram per animal, Frequency: 1 per day • Reactions: Lameness, Difficulty to rise, Joint swelling, Abnormal radiograph finding, Bone and joint disorder NOS… • Outcome: Ongoing
- Report ID: USA-USFDACVM-2026-US-014065
- Serious AE: Yes
- Treated For AE: Yes
- Sex: Female
- Age: 4.00 Year
- Weight: 34.019 Kilogram
- Case-reported brand: MSK
- Case-reported manufacturer: MSK
- Route: Unknown
- Form: Unassigned
- Dose: 75 Milligram per animal
- Frequency: 1 per day
Reactions Reported:
Lameness
Difficulty to rise
Joint swelling
Abnormal radiograph finding
Bone and joint disorder NOS
Discomfort NOS
Outcomes: Ongoing
Dog, Retriever - Labrador, Male, 12 year, 28.57 kilogram • Drug: MSK, Tablet, Oral, Dose: 0.50 tablet per animal, Frequency: 1 per day • Reactions: Vomiting • Outcome: Recovered/Normal
- Report ID: USA-USFDACVM-2026-US-014249
- Serious AE: No
- Treated For AE: No
- Sex: Male
- Age: 12.00 Year
- Weight: 28.570 Kilogram
- Case-reported brand: MSK
- Case-reported manufacturer: MSK
- Route: Oral
- Form: Tablet
- Dose: 0.50 tablet per animal
- Frequency: 1 per day
Reactions Reported:
Vomiting
Outcomes: Recovered/Normal
Dog, Setter (unspecified), Male, 14 year, 27.2 kilogram • Drug: MSK, Tablet, Oral, Dose: 0.50 tablet per animal, Frequency: 1 per day • Reactions: Death, Breathing difficulty, Weight loss • Outcome: Died
- Report ID: USA-USFDACVM-2026-US-013873
- Serious AE: Yes
- Treated For AE: No
- Sex: Male
- Age: 14.00 Year
- Weight: 27.200 Kilogram
- Case-reported brand: MSK
- Case-reported manufacturer: MSK
- Route: Oral
- Form: Tablet
- Dose: 0.50 tablet per animal
- Frequency: 1 per day
Reactions Reported:
Death
Breathing difficulty
Weight loss
Outcomes: Died
Dog, Terrier (unspecified), Female, 12.16 year, 8.8 kilogram • Drug: MSK, Tablet, Oral, Dose: 1 tablet per animal • Reactions: Seizure NOS, Intentional misuse • Outcome: Recovered/Normal
- Report ID: USA-USFDACVM-2026-US-013540
- Serious AE: Yes
- Treated For AE: No
- Sex: Female
- Age: 12.16 Year
- Weight: 8.800 Kilogram
- Case-reported brand: MSK
- Case-reported manufacturer: MSK
- Route: Oral
- Form: Tablet
- Dose: 1 tablet per animal
Reactions Reported:
Seizure NOS
Intentional misuse
Outcomes: Recovered/Normal
Dog, American Pit Bull Terrier, Female, 13 year, 34.47 kilogram • Drug: MSK, Tablet, Oral, Dose: 0.50 tablet per animal, Frequency: 1 per day • Reactions: Trembling, Panting, Medication error NOS • Outcome: Recovered/Normal
- Report ID: USA-USFDACVM-2026-US-013521
- Serious AE: No
- Treated For AE: No
- Sex: Female
- Age: 13.00 Year
- Weight: 34.470 Kilogram
- Case-reported brand: MSK
- Case-reported manufacturer: MSK
- Route: Oral
- Form: Tablet
- Dose: 0.50 tablet per animal
- Frequency: 1 per day
Reactions Reported:
Trembling
Panting
Medication error NOS
Outcomes: Recovered/Normal
Data source: FDA openFDA Animal & Veterinary adverse event reports.
Overdose Information
No approved overdose-management text is linked yet. If overdose is suspected, contact a veterinarian or emergency clinic immediately.
Storage & Handling
No approved storage guidance is linked yet for this ingredient. Use manufacturer packaging and veterinary guidance for handling/storage.
Share Your Thoughts
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This medication has not been reviewed by a veterinarian yet.
Medical Disclaimer: The medication details provided on Roxee are for informational purposes only and are not a substitute for professional veterinary advice. Always consult your veterinarian about your pet's specific needs.