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Roxee Meds Catalog

Nitenpyram

Medication catalog facts with explicit FDA-approval, off-label, source-limited, and safety context.

Both Catalog complete FDA data linked Non-Rx Tablet Multiple FDA labelers Official label facts Owner quick guide first
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Data freshness

Storefront facts
Catalog refreshed
May 5, 2026, 10:00 a.m.

These are the storefront facts Roxee uses on browse cards and quick facts.

FDA applications
FDA application data refreshed
May 5, 2026, 10:00 a.m.

Sponsor, product, and application records imported from Animal Drugs @ FDA.

Safety reports
Safety data refreshed
May 5, 2026, 10:01 a.m.

openFDA reaction terms and case summaries are supporting evidence, not proof of causality.

Source timing details
Source timing details
  • Storefront facts: Source Roxee | Refreshed May 5, 2026, 10:00 AM UTC
    The storefront fact projection used for browse cards and quick facts.
  • Animal Drugs @ FDA: Source FDA | Refreshed May 5, 2026, 10:00 AM UTC
    Applications/products are imported from FDA export data.
  • Animal Drugs @ FDA previews: Source FDA | Refreshed Feb 9, 2026, 3:05 AM UTC
    Label highlights/doc links are fetched from FDA preview endpoints.
  • Animal Drug Product Listing Directory (NDC): Source FDA | Refreshed May 5, 2026, 10:00 AM UTC
    Package/product NDCs from FDA’s electronic listing directory (XLS).
  • openFDA reaction terms: Source FDA openFDA | Refreshed May 5, 2026, 10:04 AM UTC
  • openFDA case summaries: Source FDA openFDA | Refreshed May 5, 2026, 10:04 AM UTC

Evidence

Reviewed / Updated / Sources

Reviewed by: Not available

Last reviewed: February 12, 2026

Updated: February 12, 2026, 10:44 PM UTC

Sources:
Image coming soon
Nitenpyram

Nitenpyram

Drug type: Generic ingredient • Branded profile • FDA branded products available

Both Tablet Non-Rx 100% storefront ready

Species: Both

Manufacturer: Multiple FDA labelers

Medication Snapshot

Merged from the current Roxee medication system with field-level provenance, freshness, and completeness tracking.

Nitenpyram

For the treatment of flea infestations. The concurrent use of flavored milbemycin oxime and lufenuron tablets with nitenpyram tablets is indicated to kill adult fleas and prevent flea eggs from hatching. In cats and kittens, the concurrent use of PROGRAM® Flavor Tabs® and CAPSTAR® Tablets is indicated to kill adult fleas and prevent flea eggs from hatching. The effects of PROGRAM® Flavor Tabs®, which control flea populations, and CAP STAR® Tablets, which treat flea infestations, are combined to provide a FLEA MANAGEMENT SYSTEM™. Species commonly shown: Both, Dog, Excluding Under 2 Pounds, Dogs and puppies, excluding puppies under 4 weeks age.

Generic name
Nitenpyram
Brand names
CAPSTAR®, CAPSTAR, PETARMOR CAPACTION, Nitenpyram
Manufacturer
Multiple FDA labelers
Species
Both, Dog, Excluding Under 2 Pounds, Dogs and puppies, excluding puppies under 4 weeks age, Cat And Kitten, Excluding Under 4 Weeks Of Age
Dosage forms
Tablet
Prescription
Non-prescription
Completeness
100%
Validation
Complete
Brand names
CAPSTAR® CAPSTAR PETARMOR CAPACTION Nitenpyram
Dosage forms
Tablet

Indications / Uses

For the treatment of flea infestations. The concurrent use of flavored milbemycin oxime and lufenuron tablets with nitenpyram tablets is indicated to kill adult fleas and prevent flea eggs from hatching. In cats and kittens, the concurrent use of PROGRAM® Flavor Tabs® and CAPSTAR® Tablets is indicated to kill adult fleas and prevent flea eggs from hatching. The effects of PROGRAM® Flavor Tabs®, which control flea populations, and CAP STAR® Tablets, which treat flea infestations, are combined to provide a FLEA MANAGEMENT SYSTEM™.

Warnings / Contraindications

For use in dogs, puppies, cats, and kittens 4 weeks of age and older and 2 pounds of body weight or greater. The concurrent use of nitenpyram tablets and flavored milbemycin/lufenuron tablets shall be by or on the order of a licensed veterinarian. For use in cats and kittens 4 weeks of age and older. The concurrent use of flavored milbemycin oxime and lufenuron tablets with nitenpyram tablets shall be by or on the order of a licensed veterinarian.

  • For use in dogs, puppies, cats, and kittens 4 weeks of age and older and 2 pounds of body weight or greater. The concurrent use of nitenpyram tablets and flavored milbemycin/lufenuron tablets shall be by or on the order of a licensed veterinarian. For use in cats and kittens 4 weeks of age and older. The concurrent use of flavored milbemycin oxime and lufenuron tablets with nitenpyram tablets shall be by or on the order of a licensed veterinarian.

Side Effects

Top reported reactions (openFDA): Lack of efficacy (ectoparasite) - flea, Lack of efficacy (flea), Vomiting, Lethargy (see also Central nervous system depression in 'Neurological'), Scratching, Diarrhoea.

FAQ

Both, Dog, Excluding Under 2 Pounds, Dogs and puppies, excluding puppies under 4 weeks age, Cat And Kitten, Excluding Under 4 Weeks Of Age, Cat And Kitten, Excluding Under 2 Pounds Weight

No. Roxee does not currently show this as prescription-only.

Tablet

Related Medications

Bedinvetmab Same category: Pain & Arthritis Carprofen Same category: Pain & Arthritis Deracoxib Same category: Pain & Arthritis Gabapentin Same category: Pain & Arthritis Grapiprant Same category: Pain & Arthritis Meloxicam Same category: Pain & Arthritis

Related Conditions

Fleas (Flea Infestation)

Source Transparency

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Pet Owner Quick Guide

Start here first for the safest next-step summary before the deeper medication detail.

Used for:

For the treatment of flea infestations.

Dosing note:

Exact dosing depends on your pet's species, weight, and health status. Use your veterinarian's instructions for the exact dose and schedule.

What to watch for:

  • For use in dogs, puppies, cats, and kittens 4 weeks of age and older and 2 pounds of body weight or greater
  • The concurrent use of nitenpyram tablets and flavored milbemycin/lufenuron tablets shall be by or on the order of a licensed veterinarian
  • For use in cats and kittens 4 weeks of age and older
  • The concurrent use of flavored milbemycin oxime and lufenuron tablets with nitenpyram tablets shall be by or on the order of a licensed veterinarian
  • very low energy (1 reports)
  • Oral bleeding (1 reports)
  • Not himself/herself (1 reports)

When to call the vet:

  • Repeated vomiting or diarrhea.
  • Severe lethargy (hard to wake, very low energy).
  • Collapse or fainting.
  • Trouble breathing.
  • Facial swelling or hives.
  • Blood in vomit or stool.

What to tell or ask your vet today:

  • Is this medicine the right fit for my pet’s current symptoms?
  • Which warning signs mean I should call back right away?
  • How should I handle missed doses or refusal to take the medicine?
Major cautions & emergency warning signs

Side effects to monitor:

  • For use in dogs, puppies, cats, and kittens 4 weeks of age and older and 2 pounds of body weight or greater
  • The concurrent use of nitenpyram tablets and flavored milbemycin/lufenuron tablets shall be by or on the order of a licensed veterinarian
  • For use in cats and kittens 4 weeks of age and older
  • The concurrent use of flavored milbemycin oxime and lufenuron tablets with nitenpyram tablets shall be by or on the order of a licensed veterinarian
  • very low energy

Most reported reactions:

  • Tiredness (lethargy) (1 reports)
  • Oral bleeding (1 reports)
  • Not himself/herself (1 reports)

Emergency warning signs:

  • Repeated vomiting or diarrhea.
  • Severe lethargy (hard to wake, very low energy).
  • Collapse or fainting.
  • Trouble breathing.
Talk to a Vet / Find a Vet Near You Start Symptom Intake

Quick Facts

Official label facts first, then secondary summaries. Marketing content is separated below.

Species: Both
Manufacturer: Multiple FDA labelers
Form: Tablet
Identifiers:
NADA: 141175 NADA: 141204 NADA: 141205 NDC Package: 21091-141-01 NDC Package: 21091-141-05 NDC Package: 21091-142-01 NDC Package: 21091-142-05 NDC Package: 21091-175-01 NDC Package: 21091-175-03 NDC Package: 21091-175-04 NDC Package: 21091-175-05 NDC Package: 21091-178-01 NDC Package: 21091-178-03 NDC Package: 21091-178-04 NDC Package: 21091-178-05 NDC Package: 62157-725-01 NDC Package: 73309-146-01 NDC Package: 73309-146-02 NDC Product: 21091 NDC Product: 62157
Source metadata:

Warnings / Contraindications

For use in dogs, puppies, cats, and kittens 4 weeks of age and older and 2 pounds of body weight or greater. The concurrent use of nitenpyram tablets and flavored milbemycin/lufenuron tablets shall be by or on the order of a licensed veterinarian. For use in cats and kittens 4 weeks of age and older. The concurrent use of flavored milbemycin oxime and lufenuron tablets with nitenpyram tablets shall be by or on the order of a licensed veterinarian.

  • High: For use in dogs, puppies, cats, and kittens 4 weeks of age and older and 2 pounds of body weight or greater. The concurrent use of nitenpyram tablets and flavored milbemycin/lufenuron tablets shall be by or on the order of a licensed veterinarian. For use in cats and kittens 4 weeks of age and older. The concurrent use of flavored milbemycin oxime and lufenuron tablets with nitenpyram tablets shall be by or on the order of a licensed veterinarian.
Source metadata:

Adverse Reactions

Snapshot first, detailed rows second. This section summarizes signal data and is not a diagnosis.

Tap or hover a reaction to see what it means in plain language.

Tracked signals
32
Reported cases
32
Serious reports
28
Species represented
2
Grouped by Body System
Digestive (5) · Drooling, Diarrhea, Decreased appetite Skin & allergy (2) · Facial swelling (possible allergy), Biting - pruritus Neurologic (2) · Tiredness (lethargy), Muscle tremor Behavior (1) · Anxiety Effectiveness (1) · Lack of efficacy (ectoparasite) - flea Other (21) · Oral bleeding, Not himself/herself, Not eating
Most Reported Reactions
Reaction Body system Cases Species Serious cases
Neurologic 1 Dog 1
Other 1 Cat 1
Other 1 Dog 1
Other 1 Dog 1
Other 1 Cat 1
Other 1 Cat 1
Other 1 Dog 1
Other 1 Cat 1

Species coverage: Cat (18) Dog (14)

View detailed reaction table
Reaction Body system Species Seriousness Frequency Reports
Neurologic Dog Serious - 1
Other Cat Serious - 1
Other Dog Serious - 1
Other Dog Serious - 1
Other Cat Serious - 1
Neurologic Dog Non-serious - 1
Effectiveness Cat Non-serious - 1
Other Cat Serious - 1
Other Dog Serious - 1
Other Cat Serious - 1
Other Cat Serious - 1
Other Cat Serious - 1
Other Dog Non-serious - 1
Other Dog Serious - 1
Other Cat Serious - 1
Other Cat Serious - 1
Other Cat Serious - 1
Skin & allergy Dog Serious - 1
Other Cat Serious - 1
Digestive Dog Serious - 1
Digestive Dog Serious - 1
Other Dog Serious - 1
Digestive Dog Serious - 1
Other Cat Serious - 1
Other Dog Non-serious - 1
Other Cat Serious - 1
Digestive Cat Serious - 1
Skin & allergy Cat Serious - 1
Digestive Cat Serious - 1
Behavior Cat Serious - 1
Other Dog Serious - 1
Other Cat Serious - 1
Source metadata:

Documents

Owner handouts and official technical documents open on-page first, with the original source still one click away.

Owner handouts

0
No owner handouts linked yet.

Official label / PI

0
No official label or package insert links yet.

SPL

5

FOI

4

CAPSTAR®

SPL · SPL

Open original
FDA Structured Product Label

CAPSTAR®

Rendered from Roxee's cached FDA SPL package contents for on-page reading. Use Open original for the raw FDA ZIP/XML source.

Sponsor
Sergeant’s Pet Care Products LLC
NADA
141-175
Status
OTC
Form
Tablet
Route
Oral
Species
Dog, Excluding Under 2 Pounds • Dogs and puppies, excluding puppies under 4 weeks age • Cat And Kitten, Excluding Under 4 Weeks Of Age • Cat And Kitten, Excluding Under 2 Pounds Weight
Composition / specifications
Each tablet contains 11.4 or 57 milligrams of nitenpyram.

Cats (2 - 25 Lbs)

Indication
For the treatment of flea infestations.
Dosage
One 11.4 mg tablet given once as needed, up to once daily.
Limitations
For use in dogs, puppies, cats, and kittens 4 weeks of age and older and 2 pounds of body weight or greater.

Dogs (25.1-125 Lbs)

Indication
For the treatment of flea infestations.
Dosage
One 57 mg tablet given once as needed, up to once daily.
Limitations
For use in dogs, puppies, cats, and kittens 4 weeks of age and older and 2 pounds of body weight or greater.

Dogs (2-25 Lbs)

Indication
For the treatment of flea infestations.
Dosage
One 11.4 mg tablet given once as needed, up to once daily.
Limitations
For use in dogs, puppies, cats, and kittens 4 weeks of age and older and 2 pounds of body weight or greater.

CAPSTAR SPL

SPL · Structured Product Label

Open original
FDA Structured Product Label XML for CAPSTAR. Use the source link for the full official labeling record.

PETARMOR CAPACTION SPL

SPL · Structured Product Label

Open original
FDA Structured Product Label XML for PETARMOR CAPACTION. Use the source link for the full official labeling record.

Nitenpyram SPL

SPL · Structured Product Label

Open original
FDA Structured Product Label XML for Nitenpyram. Use the source link for the full official labeling record.

Nitenpyram SPL

SPL · Structured Product Label

Open original
FDA Structured Product Label XML for Nitenpyram. Use the source link for the full official labeling record.

ucm117260.pdf

FOI · FOI

Open original

ucm117258.pdf

FOI · FOI

Open original

ucm117654.pdf

FOI · FOI summary

Open original

ucm117656.pdf

FOI · FOI summary

Open original
Source metadata:
Veterinary reference (advanced)

Canonical medication sections are above. This legacy block remains available for deeper cross-reference without cluttering the primary workflow.

At a Glance

Quick facts and links to official labeling and safety signals.

Data freshness
  • Storefront facts: Source Roxee | Refreshed May 5, 2026, 10:00 AM UTC
    The storefront fact projection used for browse cards and quick facts.
  • Animal Drugs @ FDA: Source FDA | Refreshed May 5, 2026, 10:00 AM UTC
    Applications/products are imported from FDA export data.
  • Animal Drugs @ FDA previews: Source FDA | Refreshed Feb 9, 2026, 3:05 AM UTC
    Label highlights/doc links are fetched from FDA preview endpoints.
  • Animal Drug Product Listing Directory (NDC): Source FDA | Refreshed May 5, 2026, 10:00 AM UTC
    Package/product NDCs from FDA’s electronic listing directory (XLS).
  • openFDA reaction terms: Source FDA openFDA | Refreshed May 5, 2026, 10:04 AM UTC
  • openFDA case summaries: Source FDA openFDA | Refreshed May 5, 2026, 10:04 AM UTC
Official (FDA)
Identity: Generic ingredient • FDA branded products available
Official FDA brands: CAPSTAR Nitenpyram PETARMOR CAPACTION
Manufacturer mapping: Multiple FDA labelers
Case-reported brands (openFDA): MSK
Catalog species: Both • FDA-labeled species: Cat And Kitten, Dog, Dogs and puppies
Rx/OTC: OTC
Form/route: Tablet • Oral
Applications: NADA 141-175
NDC: Packages 21091-141-01 21091-141-05 21091-142-01 21091-142-05 21091-175-01 21091-175-03 • Products 21091 62157 73309
Documents: 2 (FOI: 2) • SPL: 1 • Label highlights • Official documents
Safety (openFDA)
Top reactions: Dog 2 • Cat 1 • View
Case summaries: 13 (showing 8) • View
openFDA reports are unverified and do not prove causation.
Explore
Related conditions: Fleas (Flea Infestation)
Linked using: Usage_Inferred (0.78)
Diagnosis Codes
ICD10_CM: B88.1
Tungiasis and other infestations

Counseling and Monitoring Highlights

Global Pet owner/Vet mode is controlled in the header. This section avoids duplicate in-page persona tabs.

Owner-facing counseling points
  • For use in dogs, puppies, cats, and kittens 4 weeks of age and older and 2 pounds of body weight or greater. The concurrent use of nitenpyram tablets and flavored milbemycin/lufenuron tablets shall be by or on the order of a licensed veterinarian. For use in cats and kittens 4 weeks of age and older. The concurrent use of flavored milbemycin oxime and lufenuron tablets with nitenpyram tablets shall be by or on the order of a licensed veterinarian. (Contraindication, High)
Top reaction signals
Tiredness (lethargy) (1) Oral bleeding (1) Not himself/herself (1) Not eating (1) Not drinking (1) Increased heart rate (1) Hypersensitivity reaction (1) Hyperactivity (1)

Identifiers & Packages

Normalized identifiers (NDC/NADA/ANADA) and package metadata from regulator listings.

Identifiers
NADA: 141175 NADA: 141204 NADA: 141205 NDC Package: 21091-141-01 NDC Package: 21091-141-05 NDC Package: 21091-142-01 NDC Package: 21091-142-05 NDC Package: 21091-175-01 NDC Package: 21091-175-03 NDC Package: 21091-175-04 NDC Package: 21091-175-05 NDC Package: 21091-178-01 NDC Package: 21091-178-03 NDC Package: 21091-178-04 NDC Package: 21091-178-05 NDC Package: 62157-725-01 NDC Package: 73309-146-01 NDC Package: 73309-146-02 NDC Product: 21091 NDC Product: 62157 NDC Product: 73309
Package NDC Product NDC Form / Route Status
21091-141-01 21091 -
21091-141-05 21091 -
21091-142-01 21091 -
21091-142-05 21091 -
21091-175-01 21091 -
21091-175-03 21091 -
21091-175-04 21091 -
21091-175-05 21091 -
21091-178-01 21091 -
21091-178-03 21091 -
21091-178-04 21091 -
21091-178-05 21091 -
62157-725-01 62157 -
73309-146-01 73309 -
73309-146-02 73309 -

Enriched Documents

Documents are tiered by source trust: Official, Clinical, Manufacturer, Marketing.

  • CAPSTAR SPL • Structured Product Label • Official
    FDA Structured Product Label from the electronic animal drug product listing directory.
  • PETARMOR CAPACTION SPL • Structured Product Label • Official
    FDA Structured Product Label from the electronic animal drug product listing directory.
  • Nitenpyram SPL • Structured Product Label • Official
    FDA Structured Product Label from the electronic animal drug product listing directory.
  • Nitenpyram SPL • Structured Product Label • Official
    FDA Structured Product Label from the electronic animal drug product listing directory.
  • ucm117258.pdf • FOI summary • Official • May 17, 2021
    FDA FOI summary for application 141175
  • ucm117260.pdf • FOI summary • Official • May 17, 2021
    FDA FOI summary for application 141175
  • ucm117654.pdf • FOI summary • Official • Aug. 3, 2020
    FDA FOI summary for application 141204
  • ucm117656.pdf • FOI summary • Official • June 1, 2016
    FDA FOI summary for application 141205

Data Sources & Change Log

Every non-trivial field is expected to include provenance and update timestamps.

Official 34 Clinical 1 Manufacturer 0 Marketing 0
Current Field Facts
  • side_effects: Top reported reactions (openFDA): Lack of efficacy (ectoparasite) - flea, Lack of efficacy (flea), Vomiting, Lethargy (see also Central nervous system depressi… (Clinical, 2026-04-11)
  • contraindications: For use in dogs, puppies, cats, and kittens 4 weeks of age and older and 2 pounds of body weight or greater. The concurrent use of nitenpyram tablets and flavo… (Official, 2026-04-12)
  • contraindications: For use in dogs, puppies, cats, and kittens 4 weeks of age and older and 2 pounds of body weight or greater. The concurrent use of nitenpyram tablets and flavo… (Official, 2026-04-11)
  • contraindications: For use in dogs, puppies, cats, and kittens 4 weeks of age and older and 2 pounds of body weight or greater. The concurrent use of nitenpyram tablets and flavo… (Official, 2026-02-12)
  • indications: For the treatment of flea infestations on dogs, puppies, cats and kittens four weeks of age and 2 pounds of body weight or greater. 1. The text in the “Indicat… (Official, 2026-05-05)
  • indications: For the treatment of flea infestations on dogs, puppies, cats and kittens four weeks of age and 2 pounds of body weight or greater. 1. The text in the “Indicat… (Official, 2026-05-03)
  • indications: For the treatment of flea infestations on dogs, puppies, cats and kittens four weeks of age and 2 pounds of body weight or greater. 1. The text in the “Indicat… (Official, 2026-05-02)
  • indications: For the treatment of flea infestations on dogs, puppies, cats and kittens four weeks of age and 2 pounds of body weight or greater. 1. The text in the “Indicat… (Official, 2026-04-29)
  • indications: For the treatment of flea infestations on dogs, puppies, cats and kittens four weeks of age and 2 pounds of body weight or greater. 1. The text in the “Indicat… (Official, 2026-04-28)
  • indications: For the treatment of flea infestations on dogs, puppies, cats and kittens four weeks of age and 2 pounds of body weight or greater. 1. The text in the “Indicat… (Official, 2026-04-27)
  • indications: For the treatment of flea infestations on dogs, puppies, cats and kittens four weeks of age and 2 pounds of body weight or greater. 1. The text in the “Indicat… (Official, 2026-04-26)
  • indications: For the treatment of flea infestations on dogs, puppies, cats and kittens four weeks of age and 2 pounds of body weight or greater. 1. The text in the “Indicat… (Official, 2026-04-25)
  • indications: For the treatment of flea infestations on dogs, puppies, cats and kittens four weeks of age and 2 pounds of body weight or greater. 1. The text in the “Indicat… (Official, 2026-04-22)
  • manufacturer_name: Multiple FDA labelers (Official, 2026-05-05)
  • manufacturer_name: Multiple FDA labelers (Official, 2026-05-03)
  • manufacturer_name: Multiple FDA labelers (Official, 2026-05-02)
  • manufacturer_name: Multiple FDA labelers (Official, 2026-04-29)
  • manufacturer_name: Multiple FDA labelers (Official, 2026-04-28)
  • manufacturer_name: Multiple FDA labelers (Official, 2026-04-27)
  • manufacturer_name: Multiple FDA labelers (Official, 2026-04-26)
Recent Revisions
  • side_effects updated 2026-04-12 10:05 by etl_backfill • Backfilled from existing medication fields
  • contraindications updated 2026-04-12 10:05 by etl_backfill • Backfilled from existing medication fields
  • usage updated 2026-04-12 10:05 by etl_backfill • Backfilled from existing medication fields
  • side_effects updated 2026-04-11 10:05 by etl_backfill • Backfilled from existing medication fields
  • contraindications updated 2026-04-11 10:05 by etl_backfill • Backfilled from existing medication fields
  • usage updated 2026-04-11 10:05 by etl_backfill • Backfilled from existing medication fields
  • side_effects updated 2026-02-12 22:44 by etl_backfill • Backfilled from existing medication fields
  • contraindications updated 2026-02-12 22:44 by etl_backfill • Backfilled from existing medication fields
  • usage updated 2026-02-12 22:44 by etl_backfill • Backfilled from existing medication fields

FDA Products & Applications (Animal Drugs @ FDA)

Official sponsor/proprietary-name/application-status records linked by active ingredient.

Product Sponsor Application Status Published
CAPSTAR®
OTC
Nitenpyram
Tablet • Oral
Label highlights
Official documents
Sergeant’s Pet Care Products LLC NADA 141-175 Approved May 17, 2021

Data source: FDA Animal Drugs @ FDA (public search export).

What It's For (FDA Label Highlights)

Extracted from FDA Animal Drugs @ FDA product labeling. Always confirm details with your veterinarian.

Species: Dog, Excluding Under 2 Pounds • Dogs and puppies, excluding puppies under 4 weeks age • Cat And Kitten, Excluding Under 4 Weeks Of Age • Cat And Kitten, Excluding Under 2 Pounds Weight
Composition / specifications
Each tablet contains 11.4 or 57 milligrams of nitenpyram.
Cats (2 - 25 Lbs)
Indication
For the treatment of flea infestations.
Dosage
One 11.4 mg tablet given once as needed, up to once daily.
Limitations
For use in dogs, puppies, cats, and kittens 4 weeks of age and older and 2 pounds of body weight or greater.
Dogs (25.1-125 Lbs)
Indication
For the treatment of flea infestations.
Dosage
One 57 mg tablet given once as needed, up to once daily.
Limitations
For use in dogs, puppies, cats, and kittens 4 weeks of age and older and 2 pounds of body weight or greater.
Dogs (2-25 Lbs)
Indication
For the treatment of flea infestations.
Dosage
One 11.4 mg tablet given once as needed, up to once daily.
Limitations
For use in dogs, puppies, cats, and kittens 4 weeks of age and older and 2 pounds of body weight or greater.

FDA page: Open in Animal Drugs @ FDA

Usage

For the treatment of flea infestations. The concurrent use of flavored milbemycin oxime and lufenuron tablets with nitenpyram tablets is indicated to kill adult fleas and prevent flea eggs from hatching. In cats and kittens, the concurrent use of PROGRAM® Flavor Tabs® and CAPSTAR® Tablets is indicated to kill adult fleas and prevent flea eggs from hatching. The effects of PROGRAM® Flavor Tabs®, which control flea populations, and CAP STAR® Tablets, which treat flea infestations, are combined to provide a FLEA MANAGEMENT SYSTEM™.

Source: FDA Animal Drugs @ FDA • Reference

Contraindications

For use in dogs, puppies, cats, and kittens 4 weeks of age and older and 2 pounds of body weight or greater. The concurrent use of nitenpyram tablets and flavored milbemycin/lufenuron tablets shall be by or on the order of a licensed veterinarian. For use in cats and kittens 4 weeks of age and older. The concurrent use of flavored milbemycin oxime and lufenuron tablets with nitenpyram tablets shall be by or on the order of a licensed veterinarian.

Top Reported Reactions (openFDA)

De-duplicated reaction terms grouped by body system from FDA openFDA reports (not verified; does not prove causation).

Digestive
Drooling (1) • Dog Diarrhea (1) • Dog Decreased appetite (1) • Dog Blood in vomit (1) • Cat Appetite loss (1) • Cat

Showing top 5 for Digestive.

Skin & allergy
Facial swelling (possible allergy) (1) • Dog Biting - pruritus (1) • Cat

Showing top 5 for Skin & allergy.

Neurologic
Tiredness (1) • Dog Muscle tremor (1) • Dog

Showing top 5 for Neurologic.

Behavior
Anxiety (1) • Cat

Showing top 5 for Behavior.

Effectiveness
Lack of efficacy (ectoparasite) - flea (1) • Cat

Showing top 5 for Effectiveness.

Other
Oral bleeding (1) • Cat Not himself/herself (1) • Dog Not eating (1) • Dog Not drinking (1) • Cat Increased heart rate (1) • Cat
Show more (16)
Hypersensitivity reaction (1) • Dog Hyperactivity (1) • Cat Hiding (1) • Cat Haemorrhage NOS (1) • Cat Gait abnormality (1) • Dog Gagging (1) • Dog Found dead (1) • Cat Food refusal (1) • Cat Fever (1) • Cat Elevated creatinine (1) • Cat Decreased drinking (1) • Dog Death (1) • Cat Dazed (1) • Dog Cardiac arrest (1) • Cat Allergic reaction (1) • Dog Administration error NOS (1) • Cat

Showing top 5 for Other.

Data source: FDA openFDA Animal & Veterinary adverse event reports.

Adverse Event Case Summaries (openFDA)

These are individual FDA adverse event reports. They are unverified and do not prove the medication caused the reaction.

Cat, Domestic Shorthair, Female, 4 year, 4.082 kilogram • Drug: MSK, Tablet, Oral, Dose: 1 tablet per dose, Frequency: 1 per day • Reactions: Lack of efficacy (ectoparasite) - flea • Outcome: Outcome Unknown

  • Report ID: USA-USFDACVM-2025-US-075465
  • Serious AE: No
  • Treated For AE: No
  • Sex: Female
  • Age: 4.00 Year
  • Weight: 4.082 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Oral
  • Form: Tablet
  • Dose: 1 tablet per dose
  • Frequency: 1 per day
Reactions Reported:
Lack of efficacy (ectoparasite) - flea
Outcomes: Outcome Unknown

Cat, Domestic Shorthair, Female, 4 year, 4.082 kilogram • Drug: MSK, Tablet, Oral, Dose: 1 tablet per dose, Frequency: 1 per day • Reactions: Lack of efficacy (ectoparasite) - flea • Outcome: Outcome Unknown

  • Report ID: USA-USFDACVM-2025-US-075464
  • Serious AE: No
  • Treated For AE: No
  • Sex: Female
  • Age: 4.00 Year
  • Weight: 4.082 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Oral
  • Form: Tablet
  • Dose: 1 tablet per dose
  • Frequency: 1 per day
Reactions Reported:
Lack of efficacy (ectoparasite) - flea
Outcomes: Outcome Unknown

Dog, Spitz - German Pomeranian, Male, 10 year, 7.711 kilogram • Drug: MSK, Tablet, Oral, Dose: 1 tablet per dose, Frequency: 1 per day • Reactions: Lack of efficacy (ectoparasite) - flea, Scratching • Outcome: Outcome Unknown

  • Report ID: USA-USFDACVM-2025-US-075467
  • Serious AE: No
  • Treated For AE: No
  • Sex: Male
  • Age: 10.00 Year
  • Weight: 7.711 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Oral
  • Form: Tablet
  • Dose: 1 tablet per dose
  • Frequency: 1 per day
Reactions Reported:
Lack of efficacy (ectoparasite) - flea Scratching
Outcomes: Outcome Unknown

Dog, Dachshund (unspecified), Female, 10 year, 6.35 kilogram • Drug: MSK, Tablet, Oral, Dose: 1 tablet per dose, Frequency: 1 per day • Reactions: Lack of efficacy (ectoparasite) - flea, Scratching • Outcome: Outcome Unknown

  • Report ID: USA-USFDACVM-2025-US-075466
  • Serious AE: No
  • Treated For AE: No
  • Sex: Female
  • Age: 10.00 Year
  • Weight: 6.350 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Oral
  • Form: Tablet
  • Dose: 1 tablet per dose
  • Frequency: 1 per day
Reactions Reported:
Lack of efficacy (ectoparasite) - flea Scratching
Outcomes: Outcome Unknown

Cat, Domestic Shorthair, Male, 15 year, 7.258 kilogram • Drug: MSK, Tablet, Oral, Dose: 1 tablet per dose, Frequency: 1 per day • Reactions: Lack of efficacy (ectoparasite) - flea • Outcome: Outcome Unknown

  • Report ID: USA-USFDACVM-2025-US-075042
  • Serious AE: No
  • Treated For AE: No
  • Sex: Male
  • Age: 15.00 Year
  • Weight: 7.258 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Oral
  • Form: Tablet
  • Dose: 1 tablet per dose
  • Frequency: 1 per day
Reactions Reported:
Lack of efficacy (ectoparasite) - flea
Outcomes: Outcome Unknown

Cat, Domestic Shorthair, Male, 8 year, 7.258 kilogram • Drug: MSK, Tablet, Oral, Dose: 1 tablet per dose, Frequency: 1 per day • Reactions: Lack of efficacy (ectoparasite) - flea • Outcome: Outcome Unknown

  • Report ID: USA-USFDACVM-2025-US-075041
  • Serious AE: No
  • Treated For AE: No
  • Sex: Male
  • Age: 8.00 Year
  • Weight: 7.258 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Oral
  • Form: Tablet
  • Dose: 1 tablet per dose
  • Frequency: 1 per day
Reactions Reported:
Lack of efficacy (ectoparasite) - flea
Outcomes: Outcome Unknown

Cat, Domestic Longhair, Female, 7 year, 5.443 kilogram • Drug: MSK, Tablet, Oral, Dose: 1 tablet per dose, Frequency: 1 per day • Reactions: Lack of efficacy (ectoparasite) - flea • Outcome: Outcome Unknown

  • Report ID: USA-USFDACVM-2025-US-075040
  • Serious AE: No
  • Treated For AE: No
  • Sex: Female
  • Age: 7.00 Year
  • Weight: 5.443 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Oral
  • Form: Tablet
  • Dose: 1 tablet per dose
  • Frequency: 1 per day
Reactions Reported:
Lack of efficacy (ectoparasite) - flea
Outcomes: Outcome Unknown

Dog, ['Bichon Frise', 'Shih Tzu'], Male, 12 year, 6.804 kilogram • Drug: MSK, Tablet, Oral, Dose: 1 tablet per dose, Frequency: 1 per day • Reactions: Lack of efficacy (ectoparasite) - flea, Scratching • Outcome: Outcome Unknown

  • Report ID: USA-USFDACVM-2025-US-073507
  • Serious AE: No
  • Treated For AE: No
  • Sex: Male
  • Age: 12.00 Year
  • Weight: 6.804 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Oral
  • Form: Tablet
  • Dose: 1 tablet per dose
  • Frequency: 1 per day
Reactions Reported:
Lack of efficacy (ectoparasite) - flea Scratching
Outcomes: Outcome Unknown

Data source: FDA openFDA Animal & Veterinary adverse event reports.

Overdose Information

No approved overdose-management text is linked yet. If overdose is suspected, contact a veterinarian or emergency clinic immediately.

Storage & Handling

No approved storage guidance is linked yet for this ingredient. Use manufacturer packaging and veterinary guidance for handling/storage.

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