USA-USFDACVM-2025-US-074908
Received 2025-12-16 · MSK · MSK
- Species
- Cat
- Breed
- Domestic Shorthair
- Size / weight
- 10-24 lb (5.67 Kilogram)
- Age
- 8+ years (9 Year)
- Sex
- Female Neutered
- Region
- USA
- Reactions
- Diarrhoea
- Body systems
- Digestive
- Outcomes
- Ongoing
Roxee Medication Guide
Prednisolone
Medication reference facts with explicit FDA-approval, off-label, source-limited, and safety context. Roxee does not sell, prescribe, or dispense medications.
Both
Reference complete
FDA data linked
Rx required
Liquid (Suspension)
Multiple FDA labelers
Official label facts
Owner quick guide first
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Data freshness
Reference facts
Reference refreshed
Jun 22, 2026, 10:41 a.m.
These are the reference facts Roxee uses on browse cards and quick facts.
FDA applications
FDA application data refreshed
Jun 22, 2026, 10:41 a.m.
Sponsor, product, and application records imported from Animal Drugs @ FDA.
Safety reports
Safety data refreshed
Jun 21, 2026, 5:14 a.m.
openFDA reaction terms and case summaries are supporting evidence, not proof of causality.
Source timing details
Source timing details
-
Reference facts:
Source Roxee
| Refreshed Jun 22, 2026, 10:41 AM UTC
The reference fact projection used for browse cards and quick facts.
-
Animal Drugs @ FDA:
Source FDA
| Refreshed Jun 22, 2026, 10:40 AM UTC
Applications/products are imported from FDA export data.
-
Animal Drugs @ FDA previews:
Source FDA
| Refreshed Feb 9, 2026, 3:05 AM UTC
Label highlights/doc links are fetched from FDA preview endpoints.
-
Animal Drug Product Listing Directory (NDC):
Source FDA
| Refreshed Jun 22, 2026, 10:41 AM UTC
Package/product NDCs from FDA’s electronic listing directory (XLS).
- openFDA reaction terms: Source FDA openFDA | Refreshed Jun 22, 2026, 10:45 AM UTC
- openFDA case summaries: Source FDA openFDA | Refreshed Jun 22, 2026, 10:45 AM UTC
Image coming soon
Prednisolone
Prednisolone
Drug type: Generic ingredient • Branded profile • FDA branded products available
Both
Liquid (Suspension)
Rx required
100% reference complete
Species: Both
Manufacturer: Multiple FDA labelers
Medication Snapshot
Merged from the current Roxee medication system with field-level provenance, freshness, and completeness tracking.
Prednisolone
The drug is indicated in the treatment of dogs for conditions requiring an anti-inflammatory agent. The drug is indicated for the treatment of acute musculoskeletal inflammations such as bursitis, carpitis, and spondylitis. The drug is indicated as supportive therapy in nonspecific dermatosis such as summer eczema and atopy. The drug may be used as supportive therapy pre- and post-operatively and for various stress conditions when corticosteroids are required while the animal is being treated for a specific condition. The drug is indicated in the treatment of cats for conditions requiring an anti-inflammatory agent. The drug is indicated for the treatment of acute musculoskeletal inflammations such as bursitis, carpitis, and spondylitis. The drug is indicated as supportive therapy in nonspecific dermatosis such as summer eczema and atopy. The drug may be used as supportive therapy pre- and post-operatively and for various stress conditions when corticosteroids are required while the animal is being treated for a specific condition. The drug is indicated in the treatment of horses for conditions requiring an anti-inflammatory agent. The drug is indicated for the treatment of acute musculoskeletal inflammations such as bursitis, carpitis, and spondylitis. The drug is indicated as supportive therapy in nonspecific dermatosis such as summer eczema and atopy. The drug may be used as supportive therapy pre- and post-operatively and for various stress conditions when corticosteroids are required while the animal is being treated for a specific condition. Species commonly shown: Both, Dog, Horse, Not For Meat Production.
Generic name
Prednisolone
Brand names
Meticortelone Acetate, Solu-Delta Cortef® Sterile Powder, Prednisolone Aqueous Suspension, Prednisolone Sodium Succinate for Injection
Manufacturer
Multiple FDA labelers
Species
Both, Dog, Horse, Cat
Dosage forms
Liquid (Suspension), Liquid, Liquid (Solution), Tablet
Prescription
Prescription required
Completeness
100%
Validation
Complete
Brand names
Meticortelone Acetate
Solu-Delta Cortef® Sterile Powder
Prednisolone Aqueous Suspension
Prednisolone Sodium Succinate for Injection
Prednis-A-Vet Injection
PrednisTab®
X
Prednisolone Sodium Phosphate
PrednisTab
Prednisolone Acetate
Dosage forms
Liquid (Suspension)
Liquid
Liquid (Solution)
Tablet
Indications / Uses
The drug is indicated in the treatment of dogs for conditions requiring an anti-inflammatory agent. The drug is indicated for the treatment of acute musculoskeletal inflammations such as bursitis, carpitis, and spondylitis. The drug is indicated as supportive therapy in nonspecific dermatosis such as summer eczema and atopy. The drug may be used as supportive therapy pre- and post-operatively and for various stress conditions when corticosteroids are required while the animal is being treated for a specific condition. The drug is indicated in the treatment of cats for conditions requiring an anti-inflammatory agent. The drug is indicated for the treatment of acute musculoskeletal inflammations such as bursitis, carpitis, and spondylitis. The drug is indicated as supportive therapy in nonspecific dermatosis such as summer eczema and atopy. The drug may be used as supportive therapy pre- and post-operatively and for various stress conditions when corticosteroids are required while the animal is being treated for a specific condition. The drug is indicated in the treatment of horses for conditions requiring an anti-inflammatory agent. The drug is indicated for the treatment of acute musculoskeletal inflammations such as bursitis, carpitis, and spondylitis. The drug is indicated as supportive therapy in nonspecific dermatosis such as summer eczema and atopy. The drug may be used as supportive therapy pre- and post-operatively and for various stress conditions when corticosteroids are required while the animal is being treated for a specific condition.
Warnings / Contraindications
Federal law restricts this drug to use by or on the order of a licensed veterinarian. Not for use in horses intended for food. Federal law restricts this drug to use by or on the order of a licensed veterinarian. Clinical and experimental data have demonstrated that corticosteroids administered orally or parenterally to animals may induce the first stage of parturition when administered late in pregnancy and may precipitate premature parturition followed by dystocia, fetal death, retained placenta, and metritis. Federal law restricts this drug to use by or on the order of a licensed veterinarian.
- Federal law restricts this drug to use by or on the order of a licensed veterinarian. Not for use in horses intended for food. Federal law restricts this drug to use by or on the order of a licensed veterinarian. Clinical and experimental data have demonstrated that corticosteroids administered orally or parenterally to animals may induce the first stage of parturition when administered late in pregnancy and may precipitate premature parturition followed by dystocia, fetal death, retained placenta, and metritis. Federal law restricts this drug to use by or on the order of a licensed veterinarian.
Side Effects
Top reported reactions (openFDA): Loss of hearing, Vomiting, Deafness, Lack of efficacy - NOS, Lethargy (see also Central nervous system depression in 'Neurological'), Diarrhoea.
FAQ
Both, Dog, Horse, Not For Meat Production, Cat, Dog, Restricted During Pregnancy
Yes. Roxee shows this as prescription-only.
Liquid (Suspension), Liquid, Liquid (Solution), Tablet
Related Conditions
Source Transparency
- Verified source: https://www.roxee.ai/meds/
- Verified source: https://animaldrugsatfda.fda.gov
- Verified source: https://animaldrugsatfda.fda.gov/adafda/views/#/search
- Verified source: https://api.fda.gov/animalandveterinary/event.json
- Verified source: https://www.roxee.ai/conditions/
- Verified source: https://animaldrugsatfda.fda.gov/adafda/app/search/public/document/downloadFoi/862
- Last refreshed: Jun 22, 2026, 10:41 a.m.
- Last verified: Feb 12, 2026, 10:44 p.m.
- Validation status: Complete
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Sign in to continuePet Owner Quick Guide
Start here first for the safest next-step summary before the deeper medication detail.
Used for:
It is used in treatment of dogs when a rapid adrenal glucocorticoid and/or anti-inflammatory effect is necessary.
Dosing note:
Exact dosing depends on your pet's species, weight, and health status. Use your veterinarian's instructions for the exact dose and schedule.
What to watch for:
- Not for use in horses intended for food
- Clinical and experimental data have demonstrated that corticosteroids administered orally or parenterally to animals may induce the first stage of parturition when administered late in pregnancy and may precipitate premature parturition followed by dystocia, fetal death, retained placenta, and metritis
- wobbly/unsteady walking (1 reports)
- trouble breathing (1 reports)
- Loss of appetite (1 reports)
When to call the vet:
- Repeated vomiting or diarrhea.
- Severe lethargy (hard to wake, very low energy).
- Collapse or fainting.
- Facial swelling or hives.
- Blood in vomit or stool.
Regulatory restrictions are shown in Vet View.
What to tell or ask your vet today:
- Is this medicine the right fit for my pet’s current symptoms?
- Which warning signs mean I should call back right away?
- How should I handle missed doses or refusal to take the medicine?
Research brief
Medication Research Insights
A source-aware map of what to know, what is uncertain, and what to verify with your veterinarian.
What to know
Evidence-backed context
Limited
Roxee has limited cited overview evidence for Prednisolone; use the official documents and your veterinarian's instructions for product-specific decisions.
Source: openFDA case USA-USFDACVM-2025-US-072504
Safety signal coverage
Reported signals
32 tracked reaction signals; 32 reported cases; 22 serious reports; 2 species groups. These are reporting and label-derived signals for interpretation with a veterinarian.
Source: openFDA case USA-USFDACVM-2025-US-072504
Interpretation guardrail
Not causation
Adverse-event reports help form a watch list, but they do not prove the medication caused the reaction and they are not a risk ranking between medications.
Evidence tension
Stronger signal
Label / review
Official labels, package inserts, and reviewed summaries carry more weight than isolated reports.
Source: openFDA case USA-USFDACVM-2025-US-072504
Weaker signal
Reported data
Case reports and openFDA terms are useful for pattern awareness, but they are incomplete, can include multiple exposures, and do not estimate an individual pet's probability of harm.
Reaction signal map
Most reported reactions
Top terms
Unsteady walking (ataxia) (1 reports), Trouble breathing (dyspnea) (1 reports), Loss of appetite (1 reports), Decreased body temperature (1 reports), Death by euthanasia (1 reports)
Body systems represented
Signal grouping
Digestive (3), Skin & allergy (1), Neurologic (1), Behavior (3)
Species and breed lens
Species represented in reports
Species lens
Dog (25 reports), Cat (7 reports)
Breed metadata in reports
Metadata only
Domestic Shorthair (4), Dog (unknown) (1), ['Bichon Frise', 'Chihuahua'] (1), ['Chihuahua', 'Dog (unknown)'] (1). These are report metadata, not proof that a breed is at higher risk.
What your vet may verify
Fit for this patient
Vet check
Verify whether Prednisolone fits the pet's species, current diagnosis, age, weight, organ status, pregnancy/lactation status, and concurrent medications.
Evidence limitations
Evidence review
Separate label-backed warnings from adverse-event reports and owner observations before changing the plan.
What to watch next
Watch list
Owner-safe
Not for use in horses intended for food, Clinical and experimental data have demonstrated that corticosteroids administered orally or parente, wobbly/unsteady walking, trouble breathing, Loss of appetite
Call sooner if
Escalation
Repeated vomiting or diarrhea. Severe lethargy (hard to wake, very low energy). Collapse or fainting.
Bottom line: Use this Prednisolone brief as a structured watch list and source map, not as a reason to start, stop, or change treatment without your veterinarian.
Vet source depth
- openFDA case USA-USFDACVM-2025-US-072504 · adverse_reaction · adverse reactions
- Contraindication source · fda_animal_drugs · warnings contraindications
- FDA application profile · official_label · quick facts
- FDA application profile · official_label · quick facts
- Medication usage source · fda_animal_drugs · quick facts
- SPL · document · documents
- FOI · document · documents
- FOI · document · documents
Evidence
Review status / Updated / Sources
Review status: Clinical reviewer not listed
Updated: February 12, 2026, 10:44 PM UTC
Sources:
- FDA application profile · official_label
- FDA application profile · official_label
- Medication usage source · fda_animal_drugs
- Meticortelone Acetate · official_label
- openFDA case USA-USFDACVM-2025-US-072504 · adverse_reaction
Safety & side effects
Side effects to monitor:
- Not for use in horses intended for food
- Clinical and experimental data have demonstrated that corticosteroids administered orally or parenterally to animals may induce the first stage of parturition when administered late in pregnancy and may precipitate premature parturition followed by dystocia, fetal death, retained placenta, and metritis
- wobbly/unsteady walking
- trouble breathing
- Loss of appetite
Most reported reactions:
- Unsteady walking (ataxia) (1 reports)
- Trouble breathing (dyspnea) (1 reports)
- Loss of appetite (1 reports)
Emergency warning signs:
- Repeated vomiting or diarrhea.
- Severe lethargy (hard to wake, very low energy).
- Collapse or fainting.
- Facial swelling or hives.
Vet Fast Scan
Source-backed clinical checkpoints for quick review.
FDA-labeled species
Cat, Dog, Horse
Indication / use
It is used in treatment of dogs when a rapid adrenal glucocorticoid and/or anti-inflammatory effect is necessary.
Form / route / dose
Form: Liquid, Liquid (Solution), Liquid (Suspension), Tablet
Route: Intra-Articular, Intramuscular, Intravenous, Oral
Confirm product label and patient-specific plan.
Route: Intra-Articular, Intramuscular, Intravenous, Oral
Confirm product label and patient-specific plan.
Warnings
- High: Federal law restricts this drug to use by or on the order of a licensed veterinarian. Not for use in horses intended fo…
Adverse-event caveat
openFDA adverse-event cases are reported signals. They are not verified, do not prove causation, and do not estimate a pet's individual risk.
Source docs
- Prednis-A-Vet Injection SPL
- PrednisTab® SPL
- Meticortelone Acetate SPL
Quick Facts
Official label facts first, then secondary summaries. Marketing content is separated below.
Species: Both
Manufacturer: Multiple FDA labelers
Form: Liquid, Liquid (Solution), Liquid (Suspension), Tablet
Identifiers:
ANADA: 200784
NADA: 10312
NADA: 11080
NADA: 11403
NADA: 11437
NADA: 11593
NADA: 11700
NADA: 11703
NADA: 117973
NADA: 12204
NADA: 12437
NADA: 12444
NADA: 135771
NADA: 136212
NADA: 140921
NADA: 141298
NADA: 32322
NADA: 35161
NADA: 45288
NADA: 55005
Source metadata:
- https://animaldrugsatfda.fda.gov/adafda/views/#/home/previewsearch/98288 · official_label · FDA application profile
- https://animaldrugsatfda.fda.gov/adafda/views/#/home/previewsearch/140921 · official_label · FDA application profile
- https://animaldrugsatfda.fda.gov · fda_animal_drugs · Medication usage source
Warnings / Contraindications
Federal law restricts this drug to use by or on the order of a licensed veterinarian. Not for use in horses intended for food. Federal law restricts this drug to use by or on the order of a licensed veterinarian. Clinical and experimental data have demonstrated that corticosteroids administered orally or parenterally to animals may induce the first stage of parturition when administered late in pregnancy and may precipitate premature parturition followed by dystocia, fetal death, retained placenta, and metritis. Federal law restricts this drug to use by or on the order of a licensed veterinarian.
- High: Federal law restricts this drug to use by or on the order of a licensed veterinarian. Not for use in horses intended for food. Federal law restricts this drug to use by or on the order of a licensed veterinarian. Clinical and experimental data have demonstrated that corticosteroids administered orally or parenterally to animals may induce the first stage of parturition when administered late in pregnancy and may precipitate premature parturition followed by dystocia, fetal death, retained placenta, and metritis. Federal law restricts this drug to use by or on the order of a licensed veterinarian.
Source metadata:
- https://animaldrugsatfda.fda.gov · fda_animal_drugs · Contraindication source
Adverse Reactions
Snapshot first, detailed rows second. This section summarizes signal data and is not a diagnosis.
Reported case explorer
Filter stored openFDA reports by pet and report attributes. Counts describe reports in this data set, not risk.
openFDA adverse-event cases are reported signals. They are not verified, do not prove causation, and do not estimate a pet's individual risk.
Stored reports
15
Matching reports
7
Active filters
1
Selected filters
Body system: Digestive
Clear
Drill into common report signals
Showing up to 50 matching reports.
USA-USFDACVM-2025-US-074897
Received 2025-12-12 · MSK · MSK
- Species
- Dog
- Breed
- ['Chihuahua', 'Dog (unknown)']
- Size / weight
- Under 10 lb (2.26 Kilogram)
- Age
- Under 1 year (2 Week)
- Sex
- Female Intact
- Region
- USA
- Reactions
- IcterusDeathOther abnormal test result NOSElevated liver enzymes NOSSwollen jointLocalised hair lossSkin lesion NOSConjunctival oedemaCorneal oedemaSkin scabSwollen limbLethargy (see also Central nervous system depression in Neurological)AnorexiaEar infection NOSLocal swelling (not application site)
- Body systems
- OtherSkin & allergyNeurologicDigestive
- Outcomes
- Died
USA-USFDACVM-2025-US-073464
Received 2025-12-12 · MSK · MSK
- Species
- Dog
- Breed
- Retriever - Labrador
- Size / weight
- 50-99 lb (37.83 Kilogram)
- Age
- 8+ years (11 Year)
- Sex
- Male Neutered
- Region
- USA
- Reactions
- AnaphylaxisSeizure NOSVomitingCollapse NOS (see also Cardio-vascular and Neurological disorders)Loose bowelCongestion of mucous membraneLow blood pressureDecreased body temperature
- Body systems
- OtherNeurologicDigestive
- Outcomes
- Recovered/Normal
USA-USFDACVM-2025-US-072888
Received 2025-12-11 · MSK · MSK
- Species
- Cat
- Breed
- Domestic Longhair
- Size / weight
- 10-24 lb (5.715 Kilogram)
- Age
- 8+ years (14 Year)
- Sex
- Male Neutered
- Region
- USA
- Reactions
- SyncopeCollapse NOS (see also Cardio-vascular and Neurological disorders)AnorexiaHidingLow blood pressureHepatomegalyHepato-biliary disorder NOSIntentional misuse
- Body systems
- OtherNeurologicDigestive
- Outcomes
- Ongoing
USA-USFDACVM-2025-US-072504
Received 2025-12-04 · MSK · MSK
- Species
- Dog
- Breed
- Terrier - Bull - American Pit
- Size / weight
- 50-99 lb (29.03 Kilogram)
- Age
- 1-3 years (2 Year)
- Sex
- Male Neutered
- Region
- USA
- Reactions
- Otitis externaTrigeminus paralysisVomitingCoughMuscle atrophy (see also Muscle wasting)Elevated serum alkaline phosphatase (ALP)Elevated alanine aminotransferase (ALT)HypersalivationUnusual stool colourErythema (for urticaria see Immune SOC)Elevated gamma-glutamyl transferase (GGT)Elevated total bilirubinAbnormal ultrasound findingHepatic fibrosisHepatitisLethargy (see also Central nervous system depression in Neurological)AngioedemaGeneralised rashDyspnoeaIncreased lung soundsLeucocytosis NOSIcterusAbnormal radiograph findingJaw disorder
- Body systems
- OtherDigestiveSkin & allergyNeurologic
- Outcomes
- Ongoing
USA-USFDACVM-2025-US-072451
Received 2025-12-01 · MSK · MSK
- Species
- Cat
- Breed
- Domestic Shorthair
- Size / weight
- 10-24 lb (5.69 Kilogram)
- Age
- 4-7 years (7 Year)
- Sex
- Male Neutered
- Region
- USA
- Reactions
- Lethargy (see also Central nervous system depression in Neurological)AnorexiaElevated total bilirubinElevated gamma-glutamyl transferase (GGT)Elevated serum alkaline phosphatase (ALP)Elevated alanine aminotransferase (ALT)JaundiceEnlarged liverHidingNausea
- Body systems
- NeurologicDigestiveOther
- Outcomes
- Ongoing
USA-USFDACVM-2025-US-071120
Received 2025-12-01 · MSK · MSK
- Species
- Cat
- Breed
- Maine Coon
- Size / weight
- 10-24 lb (5.942 Kilogram)
- Age
- 8+ years (8 Year)
- Sex
- Male Unknown
- Region
- USA
- Reactions
- Pain NOSLamenessNot eatingFeverHigh pancreatic-specific lipaseLethargy (see also Central nervous system depression in Neurological)VomitingLack of efficacy - NOS
- Body systems
- OtherNeurologicDigestiveEffectiveness
- Outcomes
- Recovered/Normal
Tap or hover a reaction to see what it means in plain language.
Tracked signals
32
Reported cases
32
Serious reports
22
Species represented
2
Grouped by Body System
Digestive (3)
· Loss of appetite, Diarrhea, Decreased appetite
Skin & allergy (1)
· Application site hair loss
Neurologic (1)
· Unsteady walking (ataxia)
Behavior (3)
· Behavioral disorder (unspecified), Anxiety, Aggression
Other (24)
· Trouble breathing (dyspnea), Decreased body temperature, Death by euthanasia
Most Reported Reactions
| Reaction | Body system | Cases | Species | Serious cases |
|---|---|---|---|---|
| Neurologic | 1 | Dog | 1 | |
| Other | 1 | Dog | 1 | |
| Digestive | 1 | Dog | 1 | |
| Other | 1 | Dog | 1 | |
| Other | 1 | Cat | 1 | |
| Other | 1 | Cat | 1 | |
| Other | 1 | Dog | 1 | |
| Other | 1 | Dog | 1 |
Species coverage: Dog (25) Cat (7)
View detailed reaction table
| Reaction | Body system | Species | Seriousness | Frequency | Reports |
|---|---|---|---|---|---|
| Neurologic | Dog | Serious | - | 1 | |
| Other | Dog | Serious | - | 1 | |
| Digestive | Dog | Serious | - | 1 | |
| Digestive | Dog | Non-serious | - | 1 | |
| Other | Dog | Serious | - | 1 | |
| Digestive | Cat | Non-serious | - | 1 | |
| Other | Cat | Serious | - | 1 | |
| Other | Cat | Serious | - | 1 | |
| Other | Dog | Serious | - | 1 | |
| Other | Dog | Non-serious | - | 1 | |
| Other | Dog | Serious | - | 1 | |
| Other | Dog | Serious | - | 1 | |
| Other | Dog | Serious | - | 1 | |
| Other | Dog | Serious | - | 1 | |
| Other | Dog | Serious | - | 1 | |
| Other | Dog | Serious | - | 1 | |
| Other | Dog | Serious | - | 1 | |
| Other | Dog | Serious | - | 1 | |
| Other | Dog | Serious | - | 1 | |
| Other | Cat | Serious | - | 1 | |
| Other | Dog | Non-serious | - | 1 | |
| Behavior | Dog | Non-serious | - | 1 | |
| Other | Cat | Non-serious | - | 1 | |
| Skin & allergy | Cat | Non-serious | - | 1 | |
| Other | Cat | Non-serious | - | 1 | |
| Behavior | Dog | Non-serious | - | 1 | |
| Other | Dog | Serious | - | 1 | |
| Other | Dog | Serious | - | 1 | |
| Behavior | Dog | Non-serious | - | 1 | |
| Other | Dog | Serious | - | 1 | |
| Other | Dog | Serious | - | 1 | |
| Other | Dog | Serious | - | 1 |
Source metadata:
- https://api.fda.gov/animalandveterinary/event.json · adverse_reaction · openFDA case USA-USFDACVM-2025-US-072504
Source Documents
The most useful source links appear first; full previews and metadata stay in the veterinary/professional layer.
Use original documents to confirm product-specific warnings, ingredients, and handling details with your veterinarian.
Full source previews and metadata remain in the veterinary/professional layer.
Owner handouts
0No owner handouts linked yet.
Official label / PI
0No official label or package insert links yet.
SPL
17FOI
4Prednis-A-Vet Injection
SPL · SPL
FDA Structured Product Label
Prednis-A-Vet Injection
Rendered from Roxee's cached FDA SPL package contents for on-page reading. Use Open original for the raw FDA ZIP/XML source.
- Sponsor
- Bimeda Animal Health Ltd.
- NADA
- 98288
- Status
- RX
- Form
- Liquid (Solution)
- Route
- Intravenous
- Species
- Dog
Composition / specifications
Each milliliter contains 20 milligrams of prednisolone sodium phosphate (equivalent to 14.88 milligrams of prednisolone) in sterile aqueous solution.
Dogs
Indication
It is used in treatment of dogs when a rapid adrenal glucocorticoid and/or anti-inflammatory effect is necessary.
Dosage
It is administered intravenously in a dosage of 2 1/2 to 5 milligrams of prednisolone sodium phosphate per pound of body weight, initially for shock and shock-like states, followed by equal maintenance doses at 1-, 3-, 6-, or 10-hour intervals as determined by the condition of the animal. If permanent use is required, oral therapy (tablets) may be substituted. If therapy is to be withdrawn after prolonged use, reduce daily dose gradually over a number of days.
Limitations
Do not use in viral infections. Except in emergency therapy, do not use with tuberculosis, chronic nephritis, Cushing's disease, or peptic ulcers. With infections, use appropriate antibacterial therapy with and for at least 3 days after, discontinuance of use and disappearance of all signs of infection. Clinical and experimental data have demonstrated that corticosteroids administered orally or parenterally to animals may induce the first stage of parturition when administered during the last trimester of pregnancy and may precipitate premature parturition followed by dystocia, fetal death, retained placenta and metritis. Federal law restricts this drug to use by or on the order of a licensed veterinarian.
PrednisTab®
SPL · SPL
FDA Structured Product Label
PrednisTab®
Rendered from Roxee's cached FDA SPL package contents for on-page reading. Use Open original for the raw FDA ZIP/XML source.
- Sponsor
- Lloyd, Inc.
- NADA
- 140-921
- Status
- RX
- Form
- Tablet
- Route
- Oral
- Species
- Dog
Composition / specifications
Each tablet contains 5 or 20 milligrams prednisolone.
Dogs
Indication
For use as an anti-inflammatory agent.
Dosage
2.5 milligrams per 10 pounds (4.5 kg) body weight per day.
Limitations
Administer total daily dose orally in equally divided doses 6 to 10 hours apart until response is noted or 7 days have elapsed. When response is attained, dosage should be gradually reduced until maintenance level is achieved. Federal law restricts this drug to use by or on the order of a licensed veterinarian. Clinical and experimental data have demonstrated that corticosteroids administered orally or parenterally to animals may induce the first stage of parturition when administered during the last trimester of pregnancy and may precipitate parturition followed by dystocia, fetal death, retained placenta, and metritis. Do not use in viral infections. Systemic therapy with prednisolone is contraindicated in animals with peptic ulcer, corneal ulcer, and Cushingoid syndrome. The presence of diabetes, osteoporosis, predisposition to thrombophlebitis hypertension, congestive heart failure, renal insufficiency and active tuberculosis necessitates carefully controlled use. Some of the above conditions occur only rarely in dogs but should be kept in mind. Anti-inflammatory action of corticosteroids may mask signs of infection.
Meticortelone Acetate
SPL · SPL
FDA Structured Product Label
Meticortelone Acetate
Rendered from Roxee's cached FDA SPL package contents for on-page reading. Use Open original for the raw FDA ZIP/XML source.
- Sponsor
- Intervet, Inc.
- NADA
- 10312
- Status
- RX
- Form
- Liquid (Suspension)
- Route
- Intramuscular, Intra-Articular
- Species
- Dog • Horse • Cat
Composition / specifications
Each milliliter of sterile aqueous suspension contains 25 milligrams of prednisolone acetate.
Dogs
Indication
The drug is indicated in the treatment of dogs for conditions requiring an anti-inflammatory agent. The drug is indicated for the treatment of acute musculoskeletal inflammations such as bursitis, carpitis, and spondylitis. The drug is indicated as supportive therapy in nonspecific dermatosis such as summer eczema and atopy. The drug may be used as supportive therapy pre- and post-operatively and for various stress conditions when corticosteroids are required while the animal is being treated for a specific condition.
Dosage
The drug is administered to dogs intramuscularly at a dosage level of 10 to 50 milligrams. The dosage may be repeated when necessary. If the condition is of a chronic nature, an oral corticosteroid may be given as a maintenance dosage. The drug may be given intra-articularly to dogs at a dosage level of 5 to 25 milligrams. The dose may be repeated when necessary after 7 days for two or three doses.
Limitations
Federal law restricts this drug to use by or on the order of a licensed veterinarian.
Cats
Indication
The drug is indicated in the treatment of cats for conditions requiring an anti-inflammatory agent. The drug is indicated for the treatment of acute musculoskeletal inflammations such as bursitis, carpitis, and spondylitis. The drug is indicated as supportive therapy in nonspecific dermatosis such as summer eczema and atopy. The drug may be used as supportive therapy pre- and post-operatively and for various stress conditions when corticosteroids are required while the animal is being treated for a specific condition.
Dosage
The drug is administered to cats intramuscularly at a dosage level of 10 to 50 milligrams. The dosage may be repeated when necessary. If the condition is of a chronic nature, an oral corticosteroid may be given as a maintenance dosage. The drug may be given intra-articularly to cats at a dosage level of 5 to 25 milligrams. The dose may be repeated when necessary after 7 days for two or three doses.
Limitations
Federal law restricts this drug to use by or on the order of a licensed veterinarian.
Horses
Indication
The drug is indicated in the treatment of horses for conditions requiring an anti-inflammatory agent. The drug is indicated for the treatment of acute musculoskeletal inflammations such as bursitis, carpitis, and spondylitis. The drug is indicated as supportive therapy in nonspecific dermatosis such as summer eczema and atopy. The drug may be used as supportive therapy pre- and post-operatively and for various stress conditions when corticosteroids are required while the animal is being treated for a specific condition.
Dosage
The drug is administered to horses intra-articularly at a dosage level of 50 to 100 milligrams. The dose may be repeated when necessary. If no response is noted after 3 or 4 days, the possibility must be considered that the condition is unresponsive to prednisolone therapy.
Limitations
Not for use in horses intended for food. Federal law restricts this drug to use by or on the order of a licensed veterinarian.
Prednisolone Aqueous Suspension
SPL · SPL
This source does not expose a safe inline preview. Use the original source link for the full document.
Prednisolone Sodium Succinate for Injection
SPL · SPL
This source does not expose a safe inline preview. Use the original source link for the full document.
Solu-Delta Cortef® Sterile Powder
SPL · SPL
FDA Structured Product Label
Solu-Delta Cortef® Sterile Powder
Rendered from Roxee's cached FDA SPL package contents for on-page reading. Use Open original for the raw FDA ZIP/XML source.
- Sponsor
- Zoetis Inc.
- NADA
- 11593
- Status
- RX
- Form
- Liquid
- Route
- Intravenous, Intramuscular
- Species
- Dog • Horse • Cat
Composition / specifications
Each milliliter of prednisolone sodium succinate injection contains: Prednisolone sodium succinate equivalent in activity to 10, 20, or 50 milligrams of prednisolone.
Horses
Indication
The drug is intended for the treatment of horses.
Dosage
The dosage for horses is 50 to 100 milligrams as an initial dose given intravenously over a period of one-half to 1 minute, or intramuscularly and may be repeated in inflammatory, allergic, or other stress conditions at intervals of 12, 24, or 48 hours, depending upon the size of the animal, the severity of the condition and the response to treatment.
Limitations
Federal law restricts this drug to use by or on the order of a licensed veterinarian.
Dogs
Indication
The drug is intended for the treatment of inflammatory, allergic and less severe stress conditions, where immediate effect is not required, in dogs.
Dosage
The drug may be given intramuscularly at 1 to 5 milligrams ranging upward to 30 to 50 milligrams in large breeds of dogs. Dosage may be repeated in 12 to 24 hours and continued for 3 to 5 days if necessary. If permanent corticosteroid effect is required oral therapy with prednisolone tablets may be substituted.
Limitations
Federal law restricts this drug to use by or on the order of a licensed veterinarian.
Indication
The drug is intended for treatment of shock in dogs.
Dosage
The drug is administered intravenously at a range of 2.5 to 5 milligrams per pound of body weight as an initial dose followed by maintenance doses at 1, 3, 6, or 10 hour intervals, as determined by the condition of the animal.
Limitations
Federal law restricts this drug to use by or on the order of a licensed veterinarian.
Cats
Indication
The drug is intended for the treatment of inflammatory, allergic and less severe stress conditions, where immediate effect is not required, in cats.
Dosage
The drug may be given intramuscularly at 1 to 5 milligrams ranging upward to 30 to 50 milligrams in large breeds of dogs. Dosage may be repeated in 12 to 24 hours and continued for 3 to 5 days if necessary. If permanent corticosteroid effect is required oral therapy with prednisolone tablets may be substituted.
Limitations
Federal law restricts this drug to use by or on the order of a licensed veterinarian.
Prednisolone Acetate SPL
SPL · Structured Product Label
FDA Structured Product Label XML for Prednisolone Acetate. Use the source link for the full official labeling record.
PrednisTab SPL
SPL · Structured Product Label
FDA Structured Product Label XML for PrednisTab. Use the source link for the full official labeling record.
PrednisTab SPL
SPL · Structured Product Label
FDA Structured Product Label XML for PrednisTab. Use the source link for the full official labeling record.
PrednisTab SPL
SPL · Structured Product Label
FDA Structured Product Label XML for PrednisTab. Use the source link for the full official labeling record.
PrednisTab SPL
SPL · Structured Product Label
FDA Structured Product Label XML for PrednisTab. Use the source link for the full official labeling record.
Prednisolone Sodium Phosphate SPL
SPL · Structured Product Label
FDA Structured Product Label XML for Prednisolone Sodium Phosphate. Use the source link for the full official labeling record.
X SPL
SPL · Structured Product Label
FDA Structured Product Label XML for X. Use the source link for the full official labeling record.
Prednisolone Sodium Phosphate SPL
SPL · Structured Product Label
FDA Structured Product Label XML for Prednisolone Sodium Phosphate. Use the source link for the full official labeling record.
Prednisolone Sodium Phosphate SPL
SPL · Structured Product Label
FDA Structured Product Label XML for Prednisolone Sodium Phosphate. Use the source link for the full official labeling record.
X SPL
SPL · Structured Product Label
FDA Structured Product Label XML for X. Use the source link for the full official labeling record.
X SPL
SPL · Structured Product Label
FDA Structured Product Label XML for X. Use the source link for the full official labeling record.
N140921_Supp_11_20_1997.pdf
FOI · FOI
UCM478245.pdf
FOI · FOI
FOI Summary oA 200-784 Approved June 20, 2024.pdf
FOI · FOI summary
UCM202424.pdf
FOI · FOI summary
Source metadata:
- https://animaldrugsatfda.fda.gov/adafda/app/search/public/spl/file/1604/Prednis-A-Vet%20Injection · document · SPL
- https://animaldrugsatfda.fda.gov/adafda/app/search/public/document/downloadFoi/1381 · document · FOI
- https://animaldrugsatfda.fda.gov/adafda/app/search/public/document/downloadFoi/488 · document · FOI
- https://animaldrugsatfda.fda.gov/adafda/app/search/public/spl/file/1390/PrednisTab%C2%AE · document · SPL
- https://animaldrugsatfda.fda.gov/adafda/app/search/public/spl/file/591/Meticortelone%20Acetate · document · SPL
- https://animaldrugsatfda.fda.gov/adafda/app/search/public/spl/file/712/Prednisolone%20Aqueous%20Suspension · document · SPL
- https://animaldrugsatfda.fda.gov/adafda/app/search/public/spl/file/1474/Prednisolone%20Sodium%20Succinate%20for%20Injection · document · SPL
- https://animaldrugsatfda.fda.gov/adafda/app/search/public/spl/file/685/Solu-Delta%20Cortef%C2%AE%20Sterile%20Powder · document · SPL
- https://www.accessdata.fda.gov/spl/data/df0fa467-e6bc-4d61-97bb-9d9d021f2983/df0fa467-e6bc-4d61-97bb-9d9d021f2983.xml · document · Structured Product Label
- https://www.accessdata.fda.gov/spl/data/7e139646-a829-4854-b2c7-09d159c3c2ed/7e139646-a829-4854-b2c7-09d159c3c2ed.xml · document · Structured Product Label
Veterinary reference (advanced)
Canonical medication sections are above. This legacy block remains available for deeper cross-reference without cluttering the primary workflow.
At a Glance
Quick facts and links to official labeling and safety signals.
Data freshness
-
Reference facts:
Source Roxee
| Refreshed Jun 22, 2026, 10:41 AM UTC
The reference fact projection used for browse cards and quick facts.
-
Animal Drugs @ FDA:
Source FDA
| Refreshed Jun 22, 2026, 10:40 AM UTC
Applications/products are imported from FDA export data.
-
Animal Drugs @ FDA previews:
Source FDA
| Refreshed Feb 9, 2026, 3:05 AM UTC
Label highlights/doc links are fetched from FDA preview endpoints.
-
Animal Drug Product Listing Directory (NDC):
Source FDA
| Refreshed Jun 22, 2026, 10:41 AM UTC
Package/product NDCs from FDA’s electronic listing directory (XLS).
- openFDA reaction terms: Source FDA openFDA | Refreshed Jun 22, 2026, 10:45 AM UTC
- openFDA case summaries: Source FDA openFDA | Refreshed Jun 22, 2026, 10:45 AM UTC
Official (FDA)
Identity: Generic ingredient
• FDA branded products available
Official FDA brands:
PrednisTab
Prednisolone Acetate
Prednisolone Sodium Phosphate
X
Manufacturer mapping:
Multiple FDA labelers
Case-reported brands (openFDA):
MSK
Catalog species: Both
•
FDA-labeled species: Cat, Dog, Horse
Rx/OTC: RX
Form/route:
Liquid, Liquid (Solution), Liquid (Suspension), Tablet
• Intra-Articular, Intramuscular, Intravenous, Oral
Applications: NADA 98288 • NADA 140-921 • NADA 10312 • NADA 12444 • NADA 117-973 • NADA 11593
NDC:
Packages
11695-4469-1
11695-4470-1
11789-248-10
11789-249-10
50989-163-53
50989-286-52
•
Products
11695
11789
50989
57319
62157
73309
Explore
Related conditions:
Congestive heart failure
Corneal ulcer
Dystocia
Metritis
Shock (hypovolemic, septic, cardiogenic, anaphylactic)
Linked using:
Fda_Label (0.95),
Fda_Label (0.95),
Fda_Label (0.95)
Diagnosis Codes
ICD10_CM: E11.9
ICD10_CM: H60.90
ICD10_CM: J20.9
Type 2 diabetes mellitus without complications
Counseling and Monitoring Highlights
Global Pet owner/Vet mode is controlled in the header. This section avoids duplicate in-page persona tabs.
Owner-facing counseling points
- Federal law restricts this drug to use by or on the order of a licensed veterinarian. Not for use in horses intended for food. Federal law restricts this drug to use by or on the order of a licensed veterinarian. Clinical and experimental data have demonstrated that corticosteroids administered orally or parenterally to animals may induce the first stage of parturition when administered late in pregnancy and may precipitate premature parturition followed by dystocia, fetal death, retained placenta, and metritis. Federal law restricts this drug to use by or on the order of a licensed veterinarian. (Contraindication, High)
Top reaction signals
Unsteady walking (ataxia) (1)
Trouble breathing (dyspnea) (1)
Loss of appetite (1)
Decreased body temperature (1)
Death by euthanasia (1)
Death (1)
Deafness (1)
Cough (1)
Identifiers & Packages
Normalized identifiers (NDC/NADA/ANADA) and package metadata from regulator listings.
Identifiers
ANADA: 200784
NADA: 10312
NADA: 11080
NADA: 11403
NADA: 11437
NADA: 11593
NADA: 11700
NADA: 11703
NADA: 117973
NADA: 12204
NADA: 12437
NADA: 12444
NADA: 135771
NADA: 136212
NADA: 140921
NADA: 141298
NADA: 32322
NADA: 35161
NADA: 45288
NADA: 55005
NADA: 65090
NADA: 65259
NADA: 91534
NADA: 98288
| Package NDC | Product NDC | Form / Route | Status |
|---|---|---|---|
| 11695-4469-1 | 11695 | - | |
| 11695-4470-1 | 11695 | - | |
| 11695-7043-1 | 11695 | - | |
| 11695-7043-2 | 11695 | - | |
| 11789-248-10 | 11789 | - | |
| 11789-249-10 | 11789 | - | |
| 50989-163-53 | 50989 | - | |
| 50989-286-52 | 50989 | - | |
| 54771-1613-1 | 54771 | - | |
| 54771-1614-1 | 54771 | - | |
| 54771-3547-1 | 54771 | - | |
| 54771-8550-1 | 54771 | - | |
| 54771-8550-2 | 54771 | - | |
| 57319-441-16 | 57319 | - | |
| 58198-0813-1 | 58198 | - | |
| 58198-0813-2 | 58198 | - | |
| 62157-152-01 | 62157 | - | |
| 62157-413-01 | 62157 | - | |
| 62157-414-01 | 62157 | - | |
| 69043-042-10 | 69043 | - |
Enriched Documents
Documents are tiered by source trust: Official, Clinical, Manufacturer, Marketing.
-
Prednisolone Acetate SPL
• Structured Product Label • Official
FDA Structured Product Label from the electronic animal drug product listing directory.
-
PrednisTab SPL
• Structured Product Label • Official
FDA Structured Product Label from the electronic animal drug product listing directory.
-
PrednisTab SPL
• Structured Product Label • Official
FDA Structured Product Label from the electronic animal drug product listing directory.
-
PrednisTab SPL
• Structured Product Label • Official
FDA Structured Product Label from the electronic animal drug product listing directory.
-
PrednisTab SPL
• Structured Product Label • Official
FDA Structured Product Label from the electronic animal drug product listing directory.
-
Prednisolone Sodium Phosphate SPL
• Structured Product Label • Official
FDA Structured Product Label from the electronic animal drug product listing directory.
-
X SPL
• Structured Product Label • Official
FDA Structured Product Label from the electronic animal drug product listing directory.
-
Prednisolone Sodium Phosphate SPL
• Structured Product Label • Official
FDA Structured Product Label from the electronic animal drug product listing directory.
-
Prednisolone Sodium Phosphate SPL
• Structured Product Label • Official
FDA Structured Product Label from the electronic animal drug product listing directory.
-
X SPL
• Structured Product Label • Official
FDA Structured Product Label from the electronic animal drug product listing directory.
-
X SPL
• Structured Product Label • Official
FDA Structured Product Label from the electronic animal drug product listing directory.
-
FOI Summary oA 200-784 Approved June 20, 2024.pdf
• FOI summary • Official
• July 1, 2024
FDA FOI summary for application 200784
-
UCM478245.pdf
• FOI summary • Official
• May 17, 2017
FDA FOI summary for application 140921
-
N140921_Supp_11_20_1997.pdf
• FOI summary • Official
• May 17, 2017
FDA FOI summary for application 140921
-
UCM202424.pdf
• FOI summary • Official
• June 1, 2016
FDA FOI summary for application 141298
Data Sources & Change Log
Every non-trivial field is expected to include provenance and update timestamps.
Official 134
Clinical 1
Manufacturer 0
Marketing 0
Current Field Facts
- side_effects: Top reported reactions (openFDA): Loss of hearing, Vomiting, Deafness, Lack of efficacy - NOS, Lethargy (see also Central nervous system depression in 'Neurolo… (Clinical, 2026-04-11)
- contraindications: Federal law restricts this drug to use by or on the order of a licensed veterinarian. Not for use in horses intended for food. Federal law restricts this drug … (Official, 2026-04-12)
- contraindications: Federal law restricts this drug to use by or on the order of a licensed veterinarian. Not for use in horses intended for food. Federal law restricts this drug … (Official, 2026-04-11)
- contraindications: Federal law restricts this drug to use by or on the order of a licensed veterinarian. Not for use in horses intended for food. Federal law restricts this drug … (Official, 2026-02-12)
- indications: PrednisTab™ is intended for use in dogs. The indications for PrednisTab™ are the same as those for other anti-inflammatory steroids and comprise the various co… (Official, 2026-06-22)
- indications: PrednisTab™ is intended for use in dogs. The indications for PrednisTab™ are the same as those for other anti-inflammatory steroids and comprise the various co… (Official, 2026-06-22)
- indications: PrednisTab™ is intended for use in dogs. The indications for PrednisTab™ are the same as those for other anti-inflammatory steroids and comprise the various co… (Official, 2026-06-21)
- indications: PrednisTab™ is intended for use in dogs. The indications for PrednisTab™ are the same as those for other anti-inflammatory steroids and comprise the various co… (Official, 2026-06-20)
- indications: PrednisTab™ is intended for use in dogs. The indications for PrednisTab™ are the same as those for other anti-inflammatory steroids and comprise the various co… (Official, 2026-06-13)
- indications: PrednisTab™ is intended for use in dogs. The indications for PrednisTab™ are the same as those for other anti-inflammatory steroids and comprise the various co… (Official, 2026-06-12)
- indications: PrednisTab™ is intended for use in dogs. The indications for PrednisTab™ are the same as those for other anti-inflammatory steroids and comprise the various co… (Official, 2026-06-12)
- indications: PrednisTab™ is intended for use in dogs. The indications for PrednisTab™ are the same as those for other anti-inflammatory steroids and comprise the various co… (Official, 2026-06-11)
- indications: PrednisTab™ is intended for use in dogs. The indications for PrednisTab™ are the same as those for other anti-inflammatory steroids and comprise the various co… (Official, 2026-06-11)
- indications: PrednisTab™ is intended for use in dogs. The indications for PrednisTab™ are the same as those for other anti-inflammatory steroids and comprise the various co… (Official, 2026-06-10)
- indications: PrednisTab™ is intended for use in dogs. The indications for PrednisTab™ are the same as those for other anti-inflammatory steroids and comprise the various co… (Official, 2026-06-09)
- indications: PrednisTab™ is intended for use in dogs. The indications for PrednisTab™ are the same as those for other anti-inflammatory steroids and comprise the various co… (Official, 2026-06-08)
- indications: PrednisTab™ is intended for use in dogs. The indications for PrednisTab™ are the same as those for other anti-inflammatory steroids and comprise the various co… (Official, 2026-06-07)
- indications: PrednisTab™ is intended for use in dogs. The indications for PrednisTab™ are the same as those for other anti-inflammatory steroids and comprise the various co… (Official, 2026-06-06)
- indications: PrednisTab™ is intended for use in dogs. The indications for PrednisTab™ are the same as those for other anti-inflammatory steroids and comprise the various co… (Official, 2026-06-05)
- indications: PrednisTab™ is intended for use in dogs. The indications for PrednisTab™ are the same as those for other anti-inflammatory steroids and comprise the various co… (Official, 2026-06-04)
Recent Revisions
- side_effects updated 2026-04-12 10:05 by etl_backfill • Backfilled from existing medication fields
- contraindications updated 2026-04-12 10:05 by etl_backfill • Backfilled from existing medication fields
- usage updated 2026-04-12 10:05 by etl_backfill • Backfilled from existing medication fields
- side_effects updated 2026-04-11 10:05 by etl_backfill • Backfilled from existing medication fields
- contraindications updated 2026-04-11 10:05 by etl_backfill • Backfilled from existing medication fields
- usage updated 2026-04-11 10:05 by etl_backfill • Backfilled from existing medication fields
- side_effects updated 2026-02-12 22:44 by etl_backfill • Backfilled from existing medication fields
- contraindications updated 2026-02-12 22:44 by etl_backfill • Backfilled from existing medication fields
- usage updated 2026-02-12 22:44 by etl_backfill • Backfilled from existing medication fields
FDA Products & Applications (Animal Drugs @ FDA)
Official sponsor/proprietary-name/application-status records linked by active ingredient.
| Product | Sponsor | Application | Status | Published |
|---|---|---|---|---|
|
Prednis-A-Vet Injection
RX
Prednisolone Sodium Phosphate
Liquid (Solution)
• Intravenous
|
Bimeda Animal Health Ltd. | NADA 98288 | Approved | Oct 2, 2018 |
|
PrednisTab®
RX
Prednisolone
Tablet
• Oral
|
Lloyd, Inc. | NADA 140-921 | Approved | May 17, 2017 |
|
Meticortelone Acetate
RX
Prednisolone Acetate
Liquid (Suspension)
• Intramuscular, Intra-Articular
|
Intervet, Inc. | NADA 10312 | Approved | Jun 1, 2016 |
|
Prednisolone Aqueous Suspension
RX
Prednisolone Acetate
|
Akorn, Inc. | NADA 12444 | W | Jun 1, 2016 |
|
Prednisolone Sodium Succinate for Injection
RX
Prednisolone Sodium Succinate
|
Watson Laboratories, Inc. | NADA 117-973 | W | Jun 1, 2016 |
|
Solu-Delta Cortef® Sterile Powder
RX
Prednisolone Sodium Succinate
Liquid
• Intravenous, Intramuscular
|
Zoetis Inc. | NADA 11593 | Approved | Jun 1, 2016 |
Data source: FDA Animal Drugs @ FDA (public search export).
What It's For (FDA Label Highlights)
Extracted from FDA Animal Drugs @ FDA product labeling. Always confirm details with your veterinarian.
Species: Dog
Composition / specifications
Each milliliter contains 20 milligrams of prednisolone sodium phosphate (equivalent to 14.88 milligrams of prednisolone) in sterile aqueous solution.
Dogs
Indication
It is used in treatment of dogs when a rapid adrenal glucocorticoid and/or anti-inflammatory effect is necessary.
Dosage
It is administered intravenously in a dosage of 2 1/2 to 5 milligrams of prednisolone sodium phosphate per pound of body weight, initially for shock and shock-like states, followed by equal maintenance doses at 1-, 3-, 6-, or 10-hour intervals as determined by the condition of the animal. If permanent use is required, oral therapy (tablets) may be substituted. If therapy is to be withdrawn after prolonged use, reduce daily dose gradually over a number of days.
Limitations
Do not use in viral infections. Except in emergency therapy, do not use with tuberculosis, chronic nephritis, Cushing's disease, or peptic ulcers. With infections, use appropriate antibacterial therapy with and for at least 3 days after, discontinuance of use and disappearance of all signs of infection. Clinical and experimental data have demonstrated that corticosteroids administered orally or parenterally to animals may induce the first stage of parturition when administered during the last trimester of pregnancy and may precipitate premature parturition followed by dystocia, fetal death, retained placenta and metritis. Federal law restricts this drug to use by or on the order of a licensed veterinarian.
FDA page: Open in Animal Drugs @ FDA
Species: Dog
Composition / specifications
Each tablet contains 5 or 20 milligrams prednisolone.
Dogs
Indication
For use as an anti-inflammatory agent.
Dosage
2.5 milligrams per 10 pounds (4.5 kg) body weight per day.
Limitations
Administer total daily dose orally in equally divided doses 6 to 10 hours apart until response is noted or 7 days have elapsed. When response is attained, dosage should be gradually reduced until maintenance level is achieved. Federal law restricts this drug to use by or on the order of a licensed veterinarian. Clinical and experimental data have demonstrated that corticosteroids administered orally or parenterally to animals may induce the first stage of parturition when administered during the last trimester of pregnancy and may precipitate parturition followed by dystocia, fetal death, retained placenta, and metritis. Do not use in viral infections. Systemic therapy with prednisolone is contraindicated in animals with peptic ulcer, corneal ulcer, and Cushingoid syndrome. The presence of diabetes, osteoporosis, predisposition to thrombophlebitis hypertension, congestive heart failure, renal insufficiency and active tuberculosis necessitates carefully controlled use. Some of the above conditions occur only rarely in dogs but should be kept in mind. Anti-inflammatory action of corticosteroids may mask signs of infection.
FDA page: Open in Animal Drugs @ FDA
Species: Dog • Horse • Cat
Composition / specifications
Each milliliter of sterile aqueous suspension contains 25 milligrams of prednisolone acetate.
Dogs
Indication
The drug is indicated in the treatment of dogs for conditions requiring an anti-inflammatory agent. The drug is indicated for the treatment of acute musculoskeletal inflammations such as bursitis, carpitis, and spondylitis. The drug is indicated as supportive therapy in nonspecific dermatosis such as summer eczema and atopy. The drug may be used as supportive therapy pre- and post-operatively and for various stress conditions when corticosteroids are required while the animal is being treated for a specific condition.
Dosage
The drug is administered to dogs intramuscularly at a dosage level of 10 to 50 milligrams. The dosage may be repeated when necessary. If the condition is of a chronic nature, an oral corticosteroid may be given as a maintenance dosage. The drug may be given intra-articularly to dogs at a dosage level of 5 to 25 milligrams. The dose may be repeated when necessary after 7 days for two or three doses.
Limitations
Federal law restricts this drug to use by or on the order of a licensed veterinarian.
Cats
Indication
The drug is indicated in the treatment of cats for conditions requiring an anti-inflammatory agent. The drug is indicated for the treatment of acute musculoskeletal inflammations such as bursitis, carpitis, and spondylitis. The drug is indicated as supportive therapy in nonspecific dermatosis such as summer eczema and atopy. The drug may be used as supportive therapy pre- and post-operatively and for various stress conditions when corticosteroids are required while the animal is being treated for a specific condition.
Dosage
The drug is administered to cats intramuscularly at a dosage level of 10 to 50 milligrams. The dosage may be repeated when necessary. If the condition is of a chronic nature, an oral corticosteroid may be given as a maintenance dosage. The drug may be given intra-articularly to cats at a dosage level of 5 to 25 milligrams. The dose may be repeated when necessary after 7 days for two or three doses.
Limitations
Federal law restricts this drug to use by or on the order of a licensed veterinarian.
Horses
Indication
The drug is indicated in the treatment of horses for conditions requiring an anti-inflammatory agent. The drug is indicated for the treatment of acute musculoskeletal inflammations such as bursitis, carpitis, and spondylitis. The drug is indicated as supportive therapy in nonspecific dermatosis such as summer eczema and atopy. The drug may be used as supportive therapy pre- and post-operatively and for various stress conditions when corticosteroids are required while the animal is being treated for a specific condition.
Dosage
The drug is administered to horses intra-articularly at a dosage level of 50 to 100 milligrams. The dose may be repeated when necessary. If no response is noted after 3 or 4 days, the possibility must be considered that the condition is unresponsive to prednisolone therapy.
Limitations
Not for use in horses intended for food. Federal law restricts this drug to use by or on the order of a licensed veterinarian.
FDA page: Open in Animal Drugs @ FDA
Species: Dog • Horse • Cat
Composition / specifications
Each milliliter of prednisolone sodium succinate injection contains: Prednisolone sodium succinate equivalent in activity to 10, 20, or 50 milligrams of prednisolone.
Horses
Indication
The drug is intended for the treatment of horses.
Dosage
The dosage for horses is 50 to 100 milligrams as an initial dose given intravenously over a period of one-half to 1 minute, or intramuscularly and may be repeated in inflammatory, allergic, or other stress conditions at intervals of 12, 24, or 48 hours, depending upon the size of the animal, the severity of the condition and the response to treatment.
Limitations
Federal law restricts this drug to use by or on the order of a licensed veterinarian.
Dogs
Indication
The drug is intended for the treatment of inflammatory, allergic and less severe stress conditions, where immediate effect is not required, in dogs.
Dosage
The drug may be given intramuscularly at 1 to 5 milligrams ranging upward to 30 to 50 milligrams in large breeds of dogs. Dosage may be repeated in 12 to 24 hours and continued for 3 to 5 days if necessary. If permanent corticosteroid effect is required oral therapy with prednisolone tablets may be substituted.
Limitations
Federal law restricts this drug to use by or on the order of a licensed veterinarian.
Indication
The drug is intended for treatment of shock in dogs.
Dosage
The drug is administered intravenously at a range of 2.5 to 5 milligrams per pound of body weight as an initial dose followed by maintenance doses at 1, 3, 6, or 10 hour intervals, as determined by the condition of the animal.
Limitations
Federal law restricts this drug to use by or on the order of a licensed veterinarian.
Cats
Indication
The drug is intended for the treatment of inflammatory, allergic and less severe stress conditions, where immediate effect is not required, in cats.
Dosage
The drug may be given intramuscularly at 1 to 5 milligrams ranging upward to 30 to 50 milligrams in large breeds of dogs. Dosage may be repeated in 12 to 24 hours and continued for 3 to 5 days if necessary. If permanent corticosteroid effect is required oral therapy with prednisolone tablets may be substituted.
Limitations
Federal law restricts this drug to use by or on the order of a licensed veterinarian.
FDA page: Open in Animal Drugs @ FDA
Usage
The drug is indicated in the treatment of dogs for conditions requiring an anti-inflammatory agent. The drug is indicated for the treatment of acute musculoskeletal inflammations such as bursitis, carpitis, and spondylitis. The drug is indicated as supportive therapy in nonspecific dermatosis such as summer eczema and atopy. The drug may be used as supportive therapy pre- and post-operatively and for various stress conditions when corticosteroids are required while the animal is being treated for a specific condition. The drug is indicated in the treatment of cats for conditions requiring an anti-inflammatory agent. The drug is indicated for the treatment of acute musculoskeletal inflammations such as bursitis, carpitis, and spondylitis. The drug is indicated as supportive therapy in nonspecific dermatosis such as summer eczema and atopy. The drug may be used as supportive therapy pre- and post-operatively and for various stress conditions when corticosteroids are required while the animal is being treated for a specific condition. The drug is indicated in the treatment of horses for conditions requiring an anti-inflammatory agent. The drug is indicated for the treatment of acute musculoskeletal inflammations such as bursitis, carpitis, and spondylitis. The drug is indicated as supportive therapy in nonspecific dermatosis such as summer eczema and atopy. The drug may be used as supportive therapy pre- and post-operatively and for various stress conditions when corticosteroids are required while the animal is being treated for a specific condition.
Source: FDA Animal Drugs @ FDA • Reference
Contraindications
Federal law restricts this drug to use by or on the order of a licensed veterinarian. Not for use in horses intended for food. Federal law restricts this drug to use by or on the order of a licensed veterinarian. Clinical and experimental data have demonstrated that corticosteroids administered orally or parenterally to animals may induce the first stage of parturition when administered late in pregnancy and may precipitate premature parturition followed by dystocia, fetal death, retained placenta, and metritis. Federal law restricts this drug to use by or on the order of a licensed veterinarian.
Top Reported Reactions (openFDA)
De-duplicated reaction terms grouped by body system from FDA openFDA reports (not verified; does not prove causation).
Digestive
Loss of appetite (1)
• Dog
Diarrhea (1)
• Dog
Decreased appetite (1)
• Cat
Showing top 5 for Digestive.
Skin & allergy
Application site hair loss (1)
• Cat
Showing top 5 for Skin & allergy.
Neurologic
Unsteady walking (1)
• Dog
Showing top 5 for Neurologic.
Behavior
Behavioral disorder (1)
• Dog
Anxiety (1)
• Dog
Aggression (1)
• Dog
Showing top 5 for Behavior.
Other
Trouble breathing (1)
• Dog
Decreased body temperature (1)
• Dog
Death by euthanasia (1)
• Cat
Death (1)
• Cat
Deafness (1)
• Dog
Show more (19)
Cyanotic spots/blotchy skin (1)
• Dog
Cough (1)
• Dog
Corneal ulcer (1)
• Dog
Corneal oedema (1)
• Dog
Corneal disorder NOS (1)
• Dog
Conjunctival reddening (1)
• Dog
Conjunctival oedema (1)
• Dog
Congestion of mucous membrane (1)
• Dog
Collapse NOS (1)
• Dog
Cloudy eye (1)
• Dog
Cardiac arrest (1)
• Cat
Bumps on skin (1)
• Dog
Application site reddening (1)
• Cat
Application site bleeding (1)
• Cat
Angioedema (1)
• Dog
Anaphylaxis (1)
• Dog
Abnormal ultrasound finding (1)
• Dog
Abnormal Schirmer tear test (1)
• Dog
Abnormal radiograph finding (1)
• Dog
Showing top 5 for Other.
Data source: FDA openFDA Animal & Veterinary adverse event reports.
Adverse Event Case Summaries (openFDA)
These are individual FDA adverse event reports. They are unverified and do not prove the medication caused the reaction.
Cat, Domestic Shorthair, Male, 9.5 year, 5.09 kilogram • Drug: MSK, Oral • Reactions: Application site hair loss, Application site bleeding, Application site reddening • Outcome: Outcome Unknown
- Report ID: USA-USFDACVM-2025-US-075004
- Serious AE: No
- Treated For AE: No
- Sex: Male
- Age: 9.50 Year
- Weight: 5.090 Kilogram
- Case-reported brand: MSK
- Case-reported manufacturer: MSK
- Route: Oral
Reactions Reported:
Application site hair loss
Application site bleeding
Application site reddening
Outcomes: Outcome Unknown
Dog, Dog (unknown), Male, 4 year, 32.5 kilogram • Drug: MSK, Unknown, Dose: 2.50 Milligram per animal, Frequency: 1 per day • Reactions: Anxiety, Elevated serum alkaline phosphatase, Hypercalcaemia, Lack of efficacy - NOS, Aggression… • Outcome: Ongoing
- Report ID: USA-USFDACVM-2025-US-074790
- Serious AE: No
- Treated For AE: No
- Sex: Male
- Age: 4.00 Year
- Weight: 32.500 Kilogram
- Case-reported brand: MSK
- Case-reported manufacturer: MSK
- Route: Unknown
- Dose: 2.50 Milligram per animal
- Frequency: 1 per day
Reactions Reported:
Anxiety
Elevated serum alkaline phosphatase
Hypercalcaemia
Lack of efficacy - NOS
Aggression
Mental function decreased
Weight gain
Low sodium-potassium ratio
Low liver enzymes NOS
Growling
Behavioral disorder (unspecified)
Outcomes: Ongoing
Cat, Domestic Shorthair, Male, 11 year, 6.03 kilogram • Drug: MSK, Unknown, Dose: 0.50 Milligram per kilogram, Frequency: 1 per day • Reactions: Tremors, Shaking • Outcome: Outcome Unknown
- Report ID: USA-USFDACVM-2025-US-074916
- Serious AE: No
- Treated For AE: No
- Sex: Male
- Age: 11.00 Year
- Weight: 6.030 Kilogram
- Case-reported brand: MSK
- Case-reported manufacturer: MSK
- Route: Unknown
- Dose: 0.50 Milligram per kilogram
- Frequency: 1 per day
Reactions Reported:
Tremors
Shaking
Outcomes: Outcome Unknown
Cat, Domestic Shorthair, Female, 9 year, 5.67 kilogram • Drug: MSK, Oral, Frequency: 1 per day • Reactions: Diarrhea • Outcome: Ongoing
- Report ID: USA-USFDACVM-2025-US-074908
- Serious AE: No
- Treated For AE: Yes
- Sex: Female
- Age: 9.00 Year
- Weight: 5.670 Kilogram
- Case-reported brand: MSK
- Case-reported manufacturer: MSK
- Route: Oral
- Frequency: 1 per day
Reactions Reported:
Diarrhea
Outcomes: Ongoing
Dog, ['Bichon Frise', 'Chihuahua'], Female, 15 year, 3.493 kilogram • Drug: MSK, Unassigned, Unknown, Frequency: 1 per day • Reactions: Seizure NOS, Unsteady walking (ataxia), Urinary incontinence • Outcome: Ongoing
- Report ID: USA-USFDACVM-2025-US-074064
- Serious AE: Yes
- Treated For AE: Yes
- Sex: Female
- Age: 15.00 Year
- Weight: 3.493 Kilogram
- Case-reported brand: MSK
- Case-reported manufacturer: MSK
- Route: Unknown
- Form: Unassigned
- Frequency: 1 per day
Reactions Reported:
Seizure NOS
Unsteady walking (ataxia)
Urinary incontinence
Outcomes: Ongoing
Dog, ['Chihuahua', 'Dog (unknown)'], Female, 20 week, 2.26 kilogram • Drug: MSK, Unknown • Reactions: Icterus, Death, Other abnormal test result NOS, Elevated liver enzymes NOS, Swollen joint… • Outcome: Died
- Report ID: USA-USFDACVM-2025-US-074897
- Serious AE: Yes
- Treated For AE: Yes
- Sex: Female
- Age: 20.00 Week
- Weight: 2.260 Kilogram
- Case-reported brand: MSK
- Case-reported manufacturer: MSK
- Route: Unknown
Reactions Reported:
Icterus
Death
Other abnormal test result NOS
Elevated liver enzymes NOS
Swollen joint
Localised hair loss
Skin lesion NOS
Conjunctival oedema
Corneal oedema
Skin scab
Swollen limb
Tiredness (lethargy)
Loss of appetite
Ear infection NOS
Local swelling
Outcomes: Died
Dog, Retriever - Labrador, Male, 11 year, 37.83 kilogram • Drug: MSK, Unassigned, Unknown • Reactions: Anaphylaxis, Seizure NOS, Vomiting, Collapse NOS, Loose bowel… • Outcome: Recovered/Normal
- Report ID: USA-USFDACVM-2025-US-073464
- Serious AE: Yes
- Treated For AE: Yes
- Sex: Male
- Age: 11.00 Year
- Weight: 37.830 Kilogram
- Case-reported brand: MSK
- Case-reported manufacturer: MSK
- Route: Unknown
- Form: Unassigned
Reactions Reported:
Anaphylaxis
Seizure NOS
Vomiting
Collapse NOS
Loose bowel
Congestion of mucous membrane
Low blood pressure
Decreased body temperature
Outcomes: Recovered/Normal
Cat, Domestic Shorthair, Male, 3.16 year, 7.25 kilogram • Drug: MSK, Unknown • Reactions: Seizure NOS • Outcome: Recovered/Normal
- Report ID: USA-USFDACVM-2025-US-073345
- Serious AE: Yes
- Treated For AE: No
- Sex: Male
- Age: 3.16 Year
- Weight: 7.250 Kilogram
- Case-reported brand: MSK
- Case-reported manufacturer: MSK
- Route: Unknown
Reactions Reported:
Seizure NOS
Outcomes: Recovered/Normal
Data source: FDA openFDA Animal & Veterinary adverse event reports.
Overdose Information
No approved overdose-management text is linked yet. If overdose is suspected, contact a veterinarian or emergency clinic immediately.
Storage & Handling
No approved storage guidance is linked yet for this ingredient. Use manufacturer packaging and veterinary guidance for handling/storage.
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Medical Disclaimer: The medication details provided on Roxee are for informational purposes only and are not a substitute for professional veterinary advice. Always consult your veterinarian about your pet's specific needs.