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Roxee Medication Guide

Propofol

Medication reference facts with explicit FDA-approval, off-label, source-limited, and safety context. Roxee does not sell, prescribe, or dispense medications.

Both Reference complete FDA data linked Rx required Liquid (Emulsion) Multiple FDA labelers Official label facts Owner quick guide first
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Data freshness

Reference facts
Reference refreshed
Aug 6, 2026, 7:47 p.m.

These are the reference facts Roxee uses on browse cards and quick facts.

FDA applications
FDA application data refreshed
Aug 6, 2026, 7:47 p.m.

Sponsor, product, and application records imported from Animal Drugs @ FDA.

Safety reports
Safety data refreshed
Aug 6, 2026, 7:49 p.m.

openFDA reaction terms and case summaries are supporting evidence, not proof of causality.

Source timing details
Source timing details
  • Reference facts: Source Roxee | Refreshed Aug 6, 2026, 7:47 PM UTC
    The reference fact projection used for browse cards and quick facts.
  • Animal Drugs @ FDA: Source FDA | Refreshed Aug 6, 2026, 7:47 PM UTC
    Applications/products are imported from FDA export data.
  • Animal Drugs @ FDA previews: Source FDA | Refreshed Feb 9, 2026, 3:05 AM UTC
    Label highlights/doc links are fetched from FDA preview endpoints.
  • Animal Drug Product Listing Directory (NDC): Source FDA | Refreshed Aug 6, 2026, 7:47 PM UTC
    Package/product NDCs from FDA’s electronic listing directory (XLS).
  • openFDA reaction terms: Source FDA openFDA | Refreshed Aug 6, 2026, 7:52 PM UTC
  • openFDA case summaries: Source FDA openFDA | Refreshed Aug 6, 2026, 7:52 PM UTC
Illustration placeholder
Propofol

Propofol

Drug type: Generic ingredient • Branded profile • FDA branded products available

Both Liquid (Emulsion) Rx required 100% reference complete

Species: Both

Manufacturer: Multiple FDA labelers

Medication Snapshot

Merged from the current Roxee medication system with field-level provenance, freshness, and completeness tracking.

Propofol

The drug is indicated for use as an anesthetic as follows: As a single injection to provide general anesthesia for short procedures, for induction and maintenance of general anesthesia using incremental doses to effect, and for induction of general anesthesia where maintenance is provided by inhalant anesthetics. The drug is indicated for use as an anesthetic as follows: As a single injection to provide general anesthesia for procedures lasting up to 5 minutes; for induction and maintenance of general anesthesia using incremental doses to effect; for induction of general anesthesia where maintenance is provided by inhalant anesthetics. For induction of anesthesia. For maintenance of general anesthesia for up to 20 minutes. For induction of general anesthesia where maintenance is provided by inhalant anesthetics. Species commonly shown: Both, Dog, Cat.

Generic name
Propofol
Brand names
Rapanofal®, PropoFlo™ 28 PropoFlo™, PropoClear™, PropofolVet Multidose
Manufacturer
Multiple FDA labelers
Species
Both, Dog, Cat
Dosage forms
Liquid (Emulsion), Microemulsion, Injectable emulsion
Prescription
Prescription required
Completeness
100%
Validation
Complete
Brand names
Rapanofal® PropoFlo™ 28 PropoFlo™ PropoClear™ PropofolVet Multidose PropoFlo 28 PropoFlo Rapanofal Propofol Propovan CF
Dosage forms
Liquid (Emulsion) Microemulsion Injectable emulsion

Indications / Uses

The drug is indicated for use as an anesthetic as follows: As a single injection to provide general anesthesia for short procedures, for induction and maintenance of general anesthesia using incremental doses to effect, and for induction of general anesthesia where maintenance is provided by inhalant anesthetics. The drug is indicated for use as an anesthetic as follows: As a single injection to provide general anesthesia for procedures lasting up to 5 minutes; for induction and maintenance of general anesthesia using incremental doses to effect; for induction of general anesthesia where maintenance is provided by inhalant anesthetics. For induction of anesthesia. For maintenance of general anesthesia for up to 20 minutes. For induction of general anesthesia where maintenance is provided by inhalant anesthetics.

Warnings / Contraindications

Adequate data concerning safe use of propofol in pregnant and breeding cats have not been obtained. Doses may need adjustment for geriatric or debilitated patients. Federal law restricts this drug to use by or on the order of a licensed veterinarian. Adequate data concerning safe use of propofol in pregnant and breeding dogs have not been obtained. Doses may need adjustment for geriatric or debilitated patients. Federal (USA) law restricts this drug to use by or on the order of a licensed veterinarian. Administer by intravenous injection only. Rapid bolus administration (induction or maintenance) or accidental overdosage of propofol may cause undesirable cardiorespiratory depression including hypotension and oxygen desaturation. Respiratory arrest (apnea) could occur. When using propofol, dogs should be continuously monitored and facilities for the maintenance of a patent airway, artificial ventilation, and oxygen supplementation must be immediately available. The use of propofol in pregnant and breeding dogs has not been evaluated. Propofol crosses the placenta and, as with other general anesthetic agents, the administration of propofol may be associated with neonatal depression. Propofol has not been evaluated in dogs less than 10 weeks of age

  • Adequate data concerning safe use of propofol in pregnant and breeding cats have not been obtained. Doses may need adjustment for geriatric or debilitated patients. Federal law restricts this drug to use by or on the order of a licensed veterinarian. Adequate data concerning safe use of propofol in pregnant and breeding dogs have not been obtained. Doses may need adjustment for geriatric or debilitated patients. Federal (USA) law restricts this drug to use by or on the order of a licensed veterinarian. Administer by intravenous injection only. Rapid bolus administration (induction or maintenance) or accidental overdosage of propofol may cause undesirable cardiorespiratory depression including hypotension and oxygen desaturation. Respiratory arrest (apnea) could occur. When using propofol, dogs should be continuously monitored and facilities for the maintenance of a patent airway, artificial ventilation, and oxygen supplementation must be immediately available. The use of propofol in pregnant and breeding dogs has not been evaluated. Propofol crosses the placenta and, as with other general anesthetic agents, the administration of propofol may be associated with neonatal depression. Propofol has not been evaluated in dogs less than 10 weeks of age

Side Effects

Top reported reactions (openFDA): Death, Vomiting, Lack of efficacy - NOS, Bradycardia, Seizure NOS, Diarrhoea.

FAQ

Both, Dog, Cat

Yes. Roxee shows this as prescription-only.

Liquid (Emulsion), Microemulsion, Injectable emulsion

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Pet Owner Quick Guide

Start here first for the safest next-step summary before the deeper medication detail.

Used for:

For induction of anesthesia. For maintenance of general anesthesia by intermittent bolus injections for short procedures. For induction of general anesthesia where maintenance is provided by inhalant anesthetics.

Dosing note:

Exact dosing depends on your pet's species, weight, and health status. Use your veterinarian's instructions for the exact dose and schedule.

What to watch for:

  • Adequate data concerning safe use of propofol in pregnant and breeding cats have not been obtained
  • Doses may need adjustment for geriatric or debilitated patients
  • Adequate data concerning safe use of propofol in pregnant and breeding dogs have not been obtained
  • Federal (USA) law restricts this drug to use by or on the order of a licensed veterinarian
  • Administer by intravenous injection only
  • Rapid bolus administration (induction or maintenance) or accidental overdosage of propofol may cause undesirable cardiorespiratory depression including hypotension and oxygen desaturation
  • Respiratory arrest (apnea) could occur
  • When using propofol, dogs should be continuously monitored and facilities for the maintenance of a patent airway, artificial ventilation, and oxygen supplementation must be immediately available
  • The use of propofol in pregnant and breeding dogs has not been evaluated
  • Propofol crosses the placenta and, as with other general anesthetic agents, the administration of propofol may be associated with neonatal depression
  • Propofol has not been evaluated in dogs less than 10 weeks of age
  • wobbly/unsteady walking (1 reports)
  • Loss of appetite (1 reports)
  • Cardiac disorder NOS (1 reports)

When to call the vet:

  • Repeated vomiting or diarrhea.
  • Severe lethargy (hard to wake, very low energy).
  • Collapse or fainting.
  • Trouble breathing.
  • Facial swelling or hives.
  • Blood in vomit or stool.

Regulatory restrictions are shown in Vet View.

What to tell or ask your vet today:

  • Is this medicine the right fit for my pet’s current symptoms?
  • Which warning signs mean I should call back right away?
  • How should I handle missed doses or refusal to take the medicine?

Next actions

Talk to a Vet / Find a Vet Near You Save to pet meds Share page Review report evidence
Research brief

Medication Research Insights

A source-aware map of what to know, what is uncertain, and what to verify with your veterinarian.

Source Backed Signals

What to know

Evidence-backed context Limited

Roxee has limited cited overview evidence for Propofol; use the official documents and your veterinarian's instructions for product-specific decisions.

Source: openFDA case USA-USFDACVM-2026-US-014066
Safety signal coverage Reported signals

32 tracked reaction signals; 32 reported cases; 27 serious reports; 2 species groups. These are reporting and label-derived signals for interpretation with a veterinarian.

Source: openFDA case USA-USFDACVM-2026-US-014066
Interpretation guardrail Not causation

Adverse-event reports help form a watch list, but they do not prove the medication caused the reaction and they are not a risk ranking between medications.

Evidence tension

Stronger signal Label / review

Official labels, package inserts, and reviewed summaries carry more weight than isolated reports.

Source: openFDA case USA-USFDACVM-2026-US-014066
Weaker signal Reported data

Case reports and openFDA terms are useful for pattern awareness, but they are incomplete, can include multiple exposures, and do not estimate an individual pet's probability of harm.

Reaction signal map

Most reported reactions Top terms

Unsteady walking (ataxia) (1 reports), Loss of appetite (1 reports), Cardiac disorder NOS (1 reports), Cardiac arrest (1 reports), Burn (1 reports)

Body systems represented Signal grouping

Digestive (2), Skin & allergy (1), Neurologic (1), Behavior (2)

Explore supporting adverse reports

Species and breed lens

Species represented in reports Species lens

Cat (21 reports), Dog (11 reports)

Breed metadata in reports Metadata only

Domestic Shorthair (2), Spaniel - King Charles Cavalier (1), ['Mastiff (unspecified)', 'Crossbred Canine/dog'] (1), Ragdoll (1). These are report metadata, not proof that a breed is at higher risk.

What your vet may verify

Fit for this patient Vet check

Verify whether Propofol fits the pet's species, current diagnosis, age, weight, organ status, pregnancy/lactation status, and concurrent medications.

Evidence limitations Evidence review

Separate label-backed warnings from adverse-event reports and owner observations before changing the plan.

What to watch next

Watch list Owner-safe

Adequate data concerning safe use of propofol in pregnant and breeding cats have not been obtained, Doses may need adjustment for geriatric or debilitated patients, Adequate data concerning safe use of propofol in pregnant and breeding dogs have not been obtained, Federal (USA) law restricts this drug to use by or on the order of a licensed veterinarian, Administer by intravenous injection only

Call sooner if Escalation

Repeated vomiting or diarrhea. Severe lethargy (hard to wake, very low energy). Collapse or fainting.

Bottom line: Use this Propofol brief as a structured watch list and source map, not as a reason to start, stop, or change treatment without your veterinarian.
Vet source depth
  1. openFDA case USA-USFDACVM-2026-US-014066 · adverse_reaction · adverse reactions
  2. Contraindication source · fda_animal_drugs · warnings contraindications
  3. FDA application profile · official_label · quick facts
  4. FDA application profile · official_label · quick facts
  5. Medication usage source · fda_animal_drugs · quick facts
  6. FOI · document · documents
  7. SPL · document · documents
  8. FOI · document · documents

Evidence

Review status / Updated / Sources

Review status: Clinical reviewer not listed

Updated: February 12, 2026, 10:44 PM UTC

Sources:
Safety & side effects

Side effects to monitor:

  • Adequate data concerning safe use of propofol in pregnant and breeding cats have not been obtained
  • Doses may need adjustment for geriatric or debilitated patients
  • Adequate data concerning safe use of propofol in pregnant and breeding dogs have not been obtained
  • Federal (USA) law restricts this drug to use by or on the order of a licensed veterinarian
  • Administer by intravenous injection only

Most reported reactions:

  • Unsteady walking (ataxia) (1 reports)
  • Loss of appetite (1 reports)
  • Cardiac disorder NOS (1 reports)
Explore reported case details

Emergency warning signs:

  • Repeated vomiting or diarrhea.
  • Severe lethargy (hard to wake, very low energy).
  • Collapse or fainting.
  • Trouble breathing.
Talk to a Vet / Find a Vet Near You Start Symptom Intake

Vet Fast Scan

Source-backed clinical checkpoints for quick review.

FDA-labeled species
Cat, Dog
Indication / use
For induction of anesthesia. For maintenance of general anesthesia by intermittent bolus injections for short procedures. For induction of general anesthesia where maintenance is …
Form / route / dose
Form: Injectable emulsion, Liquid (Emulsion), Microemulsion
Route: Intravenous
Confirm product label and patient-specific plan.
Warnings
  • High: Adequate data concerning safe use of propofol in pregnant and breeding cats have not been obtained. Doses may need adju…
Adverse-event caveat
openFDA adverse-event cases are reported signals. They are not verified, do not prove causation, and do not estimate a pet's individual risk.
Source docs

Quick Facts

Official label facts first, then secondary summaries. Marketing content is separated below.

Species: Both
Manufacturer: Multiple FDA labelers
Form: Injectable emulsion, Liquid (Emulsion), Microemulsion
Identifiers:
ANADA: 200793 NADA: 141070 NADA: 141098 NADA: 141303 NDC Package: 11695-2801-1 NDC Package: 11695-7036-1 NDC Package: 13985-740-23 NDC Package: 54771-4944-1 NDC Package: 54771-4944-2 NDC Package: 54771-5206-1 NDC Package: 68504-008-01 NDC Package: 86064-001-20 NDC Package: 86136-136-31 NDC Product: 11695 NDC Product: 13985 NDC Product: 54771 NDC Product: 68504 NDC Product: 86064 NDC Product: 86136
Source metadata:

Warnings / Contraindications

Adequate data concerning safe use of propofol in pregnant and breeding cats have not been obtained. Doses may need adjustment for geriatric or debilitated patients. Federal law restricts this drug to use by or on the order of a licensed veterinarian. Adequate data concerning safe use of propofol in pregnant and breeding dogs have not been obtained. Doses may need adjustment for geriatric or debilitated patients. Federal (USA) law restricts this drug to use by or on the order of a licensed veterinarian. Administer by intravenous injection only. Rapid bolus administration (induction or maintenance) or accidental overdosage of propofol may cause undesirable cardiorespiratory depression including hypotension and oxygen desaturation. Respiratory arrest (apnea) could occur. When using propofol, dogs should be continuously monitored and facilities for the maintenance of a patent airway, artificial ventilation, and oxygen supplementation must be immediately available. The use of propofol in pregnant and breeding dogs has not been evaluated. Propofol crosses the placenta and, as with other general anesthetic agents, the administration of propofol may be associated with neonatal depression. Propofol has not been evaluated in dogs less than 10 weeks of age

  • High: Adequate data concerning safe use of propofol in pregnant and breeding cats have not been obtained. Doses may need adjustment for geriatric or debilitated patients. Federal law restricts this drug to use by or on the order of a licensed veterinarian. Adequate data concerning safe use of propofol in pregnant and breeding dogs have not been obtained. Doses may need adjustment for geriatric or debilitated patients. Federal (USA) law restricts this drug to use by or on the order of a licensed veterinarian. Administer by intravenous injection only. Rapid bolus administration (induction or maintenance) or accidental overdosage of propofol may cause undesirable cardiorespiratory depression including hypotension and oxygen desaturation. Respiratory arrest (apnea) could occur. When using propofol, dogs should be continuously monitored and facilities for the maintenance of a patent airway, artificial ventilation, and oxygen supplementation must be immediately available. The use of propofol in pregnant and breeding dogs has not been evaluated. Propofol crosses the placenta and, as with other general anesthetic agents, the administration of propofol may be associated with neonatal depression. Propofol has not been evaluated in dogs less than 10 weeks of age
Source metadata:

Adverse Reactions

Snapshot first, detailed rows second. This section summarizes signal data and is not a diagnosis.

Reported case explorer

Filter stored openFDA reports by pet and report attributes. Counts describe reports in this data set, not risk.

Clear filters
openFDA adverse-event cases are reported signals. They are not verified, do not prove causation, and do not estimate a pet's individual risk.
Stored reports
46
Matching reports
9
Active filters
1
Selected filters
Reaction: Not eating Clear
Reset
Drill into common report signals
Lethargy (see also Central nervous system depression in Neurological) (11) Death (9) Not eating (9) Behavioural disorder NOS (6) Other (44) Neurologic (19) Digestive (12) Skin & allergy (7)
Showing up to 50 matching reports.

USA-USFDACVM-2026-US-014066

Received 2026-03-25 · MSK · MSK

Serious
Species
Dog
Breed
['Mastiff (unspecified)', 'Crossbred Canine/dog']
Size / weight
50-99 lb (29.574 Kilogram)
Age
1-3 years (1 Year)
Sex
Male Neutered
Region
USA
Reactions
HypotensionNot eatingNauseaDrowsiness - systemic disorderPain NOSVomitingRegurgitationDiscoloured urineCoughCrustHyperproteinaemiaHypoalbuminaemiaLeukocytosis NOSNeutrophiliaFluid in abdomen NOSSepticaemiaIntestinal disorder NOSAbdominal cavity disorder NOSElevated lactateAbnormal cytologyDuodenal ulcerIntestinal perforationDeath by euthanasiaLack of efficacy - NOSIntentional misuse
Body systems
OtherDigestiveEffectiveness
Outcomes
Euthanized

USA-USFDACVM-2026-US-014092

Received 2026-03-16 · MSK · MSK

Serious
Species
Cat
Breed
Domestic Shorthair
Size / weight
Under 10 lb (4.354 Kilogram)
Age
4-7 years (7 Year)
Sex
Female Neutered
Region
USA
Reactions
DroolingReluctant to moveNot eatingDilated pupilsNot himself/herselfHypothermiaTachypnoeaIntentional misuseLeukopenia NOSHypoglycaemiaElevated symmetrical dimethylarginine (SDMA)AzotaemiaLow ionized calcium (Ca; Hypocalcaemia, ionized)ObtundedWeak pulseLateral recumbencyRegurgitationCardiac arrestDeath
Body systems
DigestiveOther
Outcomes
Died

USA-USFDACVM-2026-US-013265

Received 2026-03-16 · MSK · MSK

Non-serious
Species
Dog
Breed
Corso Dog
Size / weight
50-99 lb (42.184 Kilogram)
Age
1-3 years (1 Year)
Sex
Female Neutered
Region
USA
Reactions
Lethargy (see also Central nervous system depression in Neurological)Not eatingFeverInjection site lumpApplication site serous discharge
Body systems
NeurologicOther
Outcomes
Ongoing

USA-USFDACVM-2026-US-011407

Received 2026-03-09 · MSK · MSK

Serious
Species
Cat
Breed
Domestic Longhair
Size / weight
Under 10 lb (4.17 Kilogram)
Age
1-3 years (2 Year)
Sex
Female Intact
Region
USA
Reactions
Not drinkingOliguriaNeutrophiliaReluctant to moveBehavioural disorder NOSNot eatingElevated temperatureHypophosphataemiaLow creatinineHypocalcaemiaLow blood urea nitrogen (BUN)
Body systems
OtherBehavior
Outcomes
Recovered/Normal

USA-USFDACVM-2026-US-008769

Received 2026-02-28 · MSK · MSK

Serious
Species
Cat
Breed
Russian
Size / weight
Under 10 lb (4.3 Kilogram)
Age
8+ years (19 Year)
Sex
Male Neutered
Region
USA
Reactions
Not drinkingNot eatingDullnessAnaemia NOSCardiac disorder NOSHeart murmurPale mucous membraneAtaxiaOliguriaRenal failureDeath by euthanasiaInappetenceLethargy (see also Central nervous system depression in Neurological)AscitesThird eyelid protrusionLateral recumbencyAcute renal failureDehydrationProlonged capillary refill timeHyperglycaemiaSplenic neoplasm NOSHead bobbingElevated blood urea nitrogen (BUN)Elevated creatinineAbnormal radiograph findingAzotaemiaDecreased packed cell volume (PCV)DullHypernatraemia
Body systems
OtherNeurologic
Outcomes
Euthanized

USA-USFDACVM-2026-US-009973

Received 2026-02-27 · MSK · MSK

Serious
Species
Dog
Breed
Crossbred Canine/dog
Size / weight
50-99 lb (34.019 Kilogram)
Age
8+ years (10.5 Year)
Sex
Male Neutered
Region
USA
Reactions
Not eatingWalking difficultyPantingSeizure NOSDeathIntentional misuse
Body systems
OtherNeurologic
Outcomes
Died

USA-USFDACVM-2026-US-003636

Received 2026-01-23 · MSK · MSK

Non-serious
Species
Cat
Breed
Domestic Shorthair
Size / weight
Under 10 lb (3.311 Kilogram)
Age
Under 1 year (25 Week)
Sex
Female Intact
Region
USA
Reactions
Not eatingNot sleepingDilated pupilsRestlessnessNot drinkingPacingHyperactivity
Body systems
Other
Outcomes
Ongoing

USA-USFDACVM-2025-US-073842

Received 2025-12-15 · MSK · MSK

Non-serious
Species
Cat
Breed
Maine Coon
Size / weight
10-24 lb (6.1 Kilogram)
Age
Under 1 year (7 Month)
Sex
Male Intact
Region
USA
Reactions
Not eatingNot sleepingStaringFalling
Body systems
Other
Outcomes
Recovered/Normal

USA-USFDACVM-2025-US-066416

Received 2025-10-28 · MSK · MSK

Non-serious
Species
Cat
Breed
Domestic Mediumhair
Size / weight
10-24 lb (5 Kilogram)
Age
8+ years (14.6 Year)
Sex
Male Neutered
Region
USA
Reactions
Not eatingLimpingLow sodium-potassium ratio (Na:K ratio)Elevated alanine aminotransferase (ALT)Gait abnormalityHard stoolSkin inflammation NOSArthritisSwelling NOS
Body systems
OtherSkin & allergy
Outcomes
Ongoing

Tap or hover a reaction to see what it means in plain language.

Tracked signals
32
Reported cases
32
Serious reports
27
Species represented
2
Grouped by Body System
Digestive (2) · Loss of appetite, Bloody diarrhoea Skin & allergy (1) · Application site hair loss Neurologic (1) · Unsteady walking (ataxia) Behavior (2) · Behavioral disorder (unspecified), Aggression Other (26) · Cardiac disorder NOS, Cardiac arrest, Burn
Most Reported Reactions
Reaction Body system Cases Species Serious cases
Neurologic 1 Cat 1
Digestive 1 Dog 1
Other 1 Cat 1
Other 1 Dog 1
Other 1 Dog 1
Other 1 Cat 1
Other 1 Cat 1
Other 1 Cat 1

Species coverage: Cat (21) Dog (11)

View detailed reaction table
Reaction Body system Species Seriousness Frequency Reports
Neurologic Cat Serious - 1
Digestive Dog Serious - 1
Other Cat Serious - 1
Other Dog Serious - 1
Other Dog Serious - 1
Other Cat Serious - 1
Other Cat Serious - 1
Other Cat Serious - 1
Digestive Cat Serious - 1
Other Cat Serious - 1
Behavior Cat Serious - 1
Other Cat Serious - 1
Other Dog Serious - 1
Other Cat Serious - 1
Other Cat Serious - 1
Other Cat Non-serious - 1
Other Dog Non-serious - 1
Skin & allergy Cat Non-serious - 1
Other Cat Serious - 1
Other Cat Serious - 1
Behavior Cat Serious - 1
Other Cat Non-serious - 1
Other Cat Serious - 1
Other Cat Serious - 1
Other Cat Serious - 1
Other Dog Serious - 1
Other Dog Serious - 1
Other Cat Serious - 1
Other Dog Non-serious - 1
Other Dog Serious - 1
Other Dog Serious - 1
Other Dog Serious - 1
Source metadata:

Source Documents

The most useful source links appear first; full previews and metadata stay in the veterinary/professional layer.

Use original documents to confirm product-specific warnings, ingredients, and handling details with your veterinarian.

PropofolVet Multidose SPL · SPL Rapanofal® SPL · SPL PropoFlo™ 28 SPL · SPL

Full source previews and metadata remain in the veterinary/professional layer.

Owner handouts

0
No owner handouts linked yet.

Official label / PI

0
No official label or package insert links yet.

SPL

11

FOI

6

PropofolVet Multidose

SPL · SPL

Open original
FDA Structured Product Label

PropofolVet Multidose

Rendered from Roxee's cached FDA SPL package contents for on-page reading. Use Open original for the raw FDA ZIP/XML source.

Sponsor
Parnell Technologies Pty. Ltd.
ANADA
200-793
Status
RX
Form
Injectable emulsion
Route
Intravenous
Composition / specifications
10 mg/mL propofol

Dogs

Indication

For induction of anesthesia. For maintenance of general anesthesia by intermittent bolus injections for short procedures. For induction of general anesthesia where maintenance is provided by inhalant anesthetics.

Dosage

For induction of general anesthesia without the use of preanesthetics, the dosage is 7.6 milligrams per kilogram titrated against the response of the patient over 60-90 seconds or until clinical signs show the onset of anesthesia (5.0 to 7.6 mg/kg/min).The use of preanesthetic medication reduces propofol dose requirements. For the maintenance of general anesthesia without the use of preanesthetics, the dosage is 3.2 milligrams per kilogram The use of preanesthetic medication reduces propofol dose requirements. Due to the rapid metabolism of propofol, additional low doses of propofol, similar to those used for maintenance with propofol, may be required to complete the transition to inhalant maintenance anesthesia.

Rapanofal®

SPL · SPL

Open original
FDA Structured Product Label

Rapanofal®

Rendered from Roxee's cached FDA SPL package contents for on-page reading. Use Open original for the raw FDA ZIP/XML source.

Sponsor
IVAOES, INC. DBA IVAOES ANIMAL HEALTH
NADA
141-070
Status
RX
Form
Liquid (Emulsion)
Route
Intravenous
Species
Dog • Cat
Composition / specifications
The drug is a sterile, nonpyrogenic, oil-in-water emulsion containing 10 milligrams of propofol per milliliter.

Cats

Indication
The drug is indicated for use as an anesthetic as follows: As a single injection to provide general anesthesia for short procedures, for induction and maintenance of general anesthesia using incremental doses to effect, and for induction of general anesthesia where maintenance is provided by inhalant anesthetics.
Dosage
The drug is administered by intravenous injection as follows: For induction of general anesthesia without the use of preanesthetics the dosage is 8.0 to 13.2 milligrams per kilogram (3.6 to 6.0 milligrams per pound). For the maintenance of general anesthesia without the use of preanesthetics the dosage is 1.1 to 4.4 milligrams per kilogram (0.5 to 2.0 milligrams per pound). The use of preanesthetic medication reduces propofol dose requirements.
Limitations
Adequate data concerning safe use of propofol in pregnant and breeding cats have not been obtained. Doses may need adjustment for geriatric or debilitated patients. Federal law restricts this drug to use by or on the order of a licensed veterinarian.

Dogs

Indication
The drug is indicated for use as an anesthetic as follows: As a single injection to provide general anesthesia for procedures lasting up to 5 minutes; for induction and maintenance of general anesthesia using incremental doses to effect; for induction of general anesthesia where maintenance is provided by inhalant anesthetics.
Dosage
The drug is administered by intravenous injection as follows: For induction of general anesthesia without the use of preanesthetics the dosage is 5.5 to 7.0 milligrams per kilogram (2.5 to 3.2 milligrams per pound); for the maintenance of general anesthesia without the use of preanesthetics the dosage is 1.1 to 3.3 milligrams per kilogram (0.5 to 1.5 milligrams per pound). The use of preanesthetic medication reduces propofol dose requirements.
Limitations
Adequate data concerning safe use of propofol in pregnant and breeding dogs have not been obtained. Doses may need adjustment for geriatric or debilitated patients.

PropoFlo™ 28

SPL · SPL

Open original
FDA Structured Product Label

PropoFlo™ 28 PropoFlo™

Rendered from Roxee's cached FDA SPL package contents for on-page reading. Use Open original for the raw FDA ZIP/XML source.

Sponsor
Zoetis Inc.
NADA
141-098
Status
RX
Form
Liquid (Emulsion)
Route
Intravenous
Species
Dog
Composition / specifications
Each mL contains 10 mg propofol.

Dogs

Indication
For induction of anesthesia. For maintenance of general anesthesia for up to 20 minutes. For induction of general anesthesia where maintenance is provided by inhalant anesthetics.
Dosage
For induction of general anesthesia without the use of preanesthetics, the dosage is 5.5 to 7.6 milligrams per kilogram (2.5 to 3.2 milligrams per pound)The use of preanesthetic medication reduces propofol dose requirements. For the maintenance of general anesthesia without the use of preanesthetics, the dosage is 2.2 to 3.2 milligrams per kilogram (0.5 to 1.5 milligrams per pound. The use of preanesthetic medication reduces propofol dose requirements.
Limitations
Federal (USA) law restricts this drug to use by or on the order of a licensed veterinarian. Administer by intravenous injection only. Rapid bolus administration (induction or maintenance) or accidental overdosage of propofol may cause undesirable cardiorespiratory depression including hypotension and oxygen desaturation. Respiratory arrest (apnea) could occur. When using propofol, dogs should be continuously monitored and facilities for the maintenance of a patent airway, artificial ventilation, and oxygen supplementation must be immediately available. The use of propofol in pregnant and breeding dogs has not been evaluated. Propofol crosses the placenta and, as with other general anesthetic agents, the administration of propofol may be associated with neonatal depression. Propofol has not been evaluated in dogs less than 10 weeks of age

PropoFlo™

SPL · SPL

Open original
FDA Structured Product Label

PropoFlo™ 28 PropoFlo™

Rendered from Roxee's cached FDA SPL package contents for on-page reading. Use Open original for the raw FDA ZIP/XML source.

Sponsor
Zoetis Inc.
NADA
141-098
Status
RX
Form
Liquid (Emulsion)
Route
Intravenous
Species
Dog
Composition / specifications
Each mL contains 10 mg propofol.

Dogs

Indication
For induction of anesthesia. For maintenance of general anesthesia for up to 20 minutes. For induction of general anesthesia where maintenance is provided by inhalant anesthetics.
Dosage
For induction of general anesthesia without the use of preanesthetics, the dosage is 5.5 to 7.6 milligrams per kilogram (2.5 to 3.2 milligrams per pound)The use of preanesthetic medication reduces propofol dose requirements. For the maintenance of general anesthesia without the use of preanesthetics, the dosage is 2.2 to 3.2 milligrams per kilogram (0.5 to 1.5 milligrams per pound. The use of preanesthetic medication reduces propofol dose requirements.
Limitations
Federal (USA) law restricts this drug to use by or on the order of a licensed veterinarian. Administer by intravenous injection only. Rapid bolus administration (induction or maintenance) or accidental overdosage of propofol may cause undesirable cardiorespiratory depression including hypotension and oxygen desaturation. Respiratory arrest (apnea) could occur. When using propofol, dogs should be continuously monitored and facilities for the maintenance of a patent airway, artificial ventilation, and oxygen supplementation must be immediately available. The use of propofol in pregnant and breeding dogs has not been evaluated. Propofol crosses the placenta and, as with other general anesthetic agents, the administration of propofol may be associated with neonatal depression. Propofol has not been evaluated in dogs less than 10 weeks of age

PropoClear™

SPL · SPL

Open original
FDA Structured Product Label

PropoClear™

Rendered from Roxee's cached FDA SPL package contents for on-page reading. Use Open original for the raw FDA ZIP/XML source.

Sponsor
Zoetis Inc.
NADA
141-303
Status
RX
Form
Microemulsion
Route
Intravenous
Species
Dog • Cat
Composition / specifications
Each mL contains 10 mg propofol.

Dogs

Indication
For the induction and maintenance of anesthesia and for induction followed by maintenance with an inhalant anesthetic.
Dosage
Induction of General Anesthesia in Dogs: Induction dose guidelines are 4.0 to 6.5 mg/kg in dogs that do not receive a preanesthetic, and 1.4 to 6.5 mg/kg in dogs that receive a preanesthetic. The mean PROPOCLEAR induction dose is reduced by 20 to 30% for dogs that receive a preanesthetic (dose sparing effect). Anesthesia is usually observed within 60 seconds after the end of the induction dose administration. Duration of anesthesia following the recommended induction dose is approximately 4 minutes without a preanesthetic and 4 to 11 minutes with a preanesthetic. Individual anesthesia times may vary. Maintenance of General Anesthesia in Dogs: Anesthesia can be maintained by administration of PROPOCLEAR using intermittent IV injections. For dogs, the duration of anesthesia following a PROPOCLEAR maintenance dose is approximately 3 to 5 minutes. Clinical response may vary, and is determined by the dose, the rate of administration, and the frequency of maintenance injections. The maintenance dose and frequency should be based on the patient’s response. Sighthounds may need lower maintenance doses of PROPOCLEAR, and the time between maintenance dose administration and for recovery may be longer.
Limitations
Federal law restricts this drug to use by or on the order of a licensed veterinarian. When using propofol, patients should be continuously monitored and facilities for the maintenance of a patient airway, artificial ventilation, and oxygen supplementation must be immediately available.

Cats

Indication
For the induction and maintenance of anesthesia and for induction followed by maintenance with an inhalant anesthetic.
Dosage
Induction of General Anesthesia in Cats: Induction dose guidelines are 4.1 to 8.0 mg/kg for cats that do not receive a preanesthetic, and 2.7 to 8.0 mg/kg for cats that receive a preanesthetic. The PROPOCLEAR induction dose is reduced by 16 to 24% for cats that receive a preanesthetic (dose sparing effect). Anesthesia is usually observed within 60 seconds after the end of the induction dose administration. Duration of anesthesia following the recommended induction dose is approximately 3 minutes without a preanesthetic and 3 to 6 minutes with a preanesthetic. Full standing recovery occurs within approximately 30 minutes in cats. Individual anesthesia times vary. The actual induction dose should be based on patient response. Maintenance of General Anesthesia in Cats: Anesthesia can be maintained by administration of PROPOCLEAR using intermittent IV injections. For cats, the duration of anesthesia following each PROPOCLEAR maintenance dose is approximately 3 to 5 minutes. Clinical response may vary, and is determined by the dose, rate of administration and frequency of maintenance injections. PROPOCLEAR maintenance dose sparing is greater in cats that receive a preanesthetic. The maintenance dose and frequency should be based on the patient’s response.
Limitations
Federal law restricts this drug to use by or on the order of a licensed veterinarian. When using propofol, patients should be continuously monitored and facilities for the maintenance of a patient airway, artificial ventilation, and oxygen supplementation must be immediately available.

Propovan CF SPL

SPL · Structured Product Label

Open original
FDA Structured Product Label XML for Propovan CF. Use the source link for the full official labeling record.

Propofol SPL

SPL · Structured Product Label

Open original
FDA Structured Product Label XML for Propofol. Use the source link for the full official labeling record.

PropoFlo 28 SPL

SPL · Structured Product Label

Open original
FDA Structured Product Label XML for PropoFlo 28. Use the source link for the full official labeling record.

Rapanofal SPL

SPL · Structured Product Label

Open original
FDA Structured Product Label XML for Rapanofal. Use the source link for the full official labeling record.

PropoFlo SPL

SPL · Structured Product Label

Open original
FDA Structured Product Label XML for PropoFlo. Use the source link for the full official labeling record.

Rapanofal SPL

SPL · Structured Product Label

Open original
FDA Structured Product Label XML for Rapanofal. Use the source link for the full official labeling record.

FOI Summary oA 200-793 Approved November 18, 2024.pdf

FOI · FOI

Open original

ucm116781.pdf

FOI · FOI

Open original

UCM488658.pdf

FOI · FOI

Open original

UCM248263.pdf

FOI · FOI

Open original

UCM355533.pdf

FOI · FOI

Open original

UCM224476.pdf

FOI · FOI

Open original
Source metadata:
Veterinary reference (advanced)

Canonical medication sections are above. This legacy block remains available for deeper cross-reference without cluttering the primary workflow.

At a Glance

Quick facts and links to official labeling and safety signals.

Data freshness
  • Reference facts: Source Roxee | Refreshed Aug 6, 2026, 7:47 PM UTC
    The reference fact projection used for browse cards and quick facts.
  • Animal Drugs @ FDA: Source FDA | Refreshed Aug 6, 2026, 7:47 PM UTC
    Applications/products are imported from FDA export data.
  • Animal Drugs @ FDA previews: Source FDA | Refreshed Feb 9, 2026, 3:05 AM UTC
    Label highlights/doc links are fetched from FDA preview endpoints.
  • Animal Drug Product Listing Directory (NDC): Source FDA | Refreshed Aug 6, 2026, 7:47 PM UTC
    Package/product NDCs from FDA’s electronic listing directory (XLS).
  • openFDA reaction terms: Source FDA openFDA | Refreshed Aug 6, 2026, 7:52 PM UTC
  • openFDA case summaries: Source FDA openFDA | Refreshed Aug 6, 2026, 7:52 PM UTC
Official (FDA)
Identity: Generic ingredient • FDA branded products available
Official FDA brands: PropoFlo PropoFlo 28 Propofol Propovan CF Rapanofal
Manufacturer mapping: Multiple FDA labelers
Case-reported brands (openFDA): MSK
Catalog species: Both • FDA-labeled species: Cat, Dog
Rx/OTC: RX
Form/route: Injectable emulsion, Liquid (Emulsion), Microemulsion • Intravenous
Applications: ANADA 200-793 • NADA 141-070 • NADA 141-098 • NADA 141-303
NDC: Packages 11695-2801-1 13985-740-23 54771-4944-1 54771-4944-2 54771-5206-1 86064-001-20 • Products 11695 13985 54771 86064
Documents: 6 (FOI: 6) • SPL: 5 • Label highlights • Official documents
Safety (openFDA)
Top reactions: Dog 81 • Cat 144 • View
Case summaries: 46 (showing 8) • View
openFDA reports are unverified and do not prove causation.
Diagnosis Codes

Diagnosis-code mappings are not available for this medication yet.

Counseling and Monitoring Highlights

Global Pet owner/Vet mode is controlled in the header. This section avoids duplicate in-page persona tabs.

Owner-facing counseling points
  • Adequate data concerning safe use of propofol in pregnant and breeding cats have not been obtained. Doses may need adjustment for geriatric or debilitated patients. Federal law restricts this drug to use by or on the order of a licensed veterinarian. Adequate data concerning safe use of propofol in pregnant and breeding dogs have not been obtained. Doses may need adjustment for geriatric or debilitated patients. Federal (USA) law restricts this drug to use by or on the order of a licensed veterinarian. Administer by intravenous injection only. Rapid bolus administration (induction or maintenance) or accidental overdosage of propofol may cause undesirable cardiorespiratory depression including hypotension and oxygen desaturation. Respiratory arrest (apnea) could occur. When using propofol, dogs should be continuously monitored and facilities for the maintenance of a patent airway, artificial ventilation, and oxygen supplementation must be immediately available. The use of propofol in pregnant and breeding dogs has not been evaluated. Propofol crosses the placenta and, as with other general anesthetic agents, the administration of propofol may be associated with neonatal depression. Propofol has not been evaluated in dogs less than 10 weeks of age (Contraindication, High)
Top reaction signals
Unsteady walking (ataxia) (1) Loss of appetite (1) Cardiac disorder NOS (1) Cardiac arrest (1) Burn (1) Breathing difficulty (1) Bradycardia (1) Bloody stool (1)

Identifiers & Packages

Normalized identifiers (NDC/NADA/ANADA) and package metadata from regulator listings.

Identifiers
ANADA: 200793 NADA: 141070 NADA: 141098 NADA: 141303 NDC Package: 11695-2801-1 NDC Package: 11695-7036-1 NDC Package: 13985-740-23 NDC Package: 54771-4944-1 NDC Package: 54771-4944-2 NDC Package: 54771-5206-1 NDC Package: 68504-008-01 NDC Package: 86064-001-20 NDC Package: 86136-136-31 NDC Product: 11695 NDC Product: 13985 NDC Product: 54771 NDC Product: 68504 NDC Product: 86064 NDC Product: 86136
Package NDC Product NDC Form / Route Status
11695-2801-1 11695 -
11695-7036-1 11695 -
13985-740-23 13985 -
54771-4944-1 54771 -
54771-4944-2 54771 -
54771-5206-1 54771 -
68504-008-01 68504 -
86064-001-20 86064 -
86136-136-31 86136 -

Enriched Documents

Documents are tiered by source trust: Official, Clinical, Manufacturer, Marketing.

  • Propovan CF SPL • Structured Product Label • Official
    FDA Structured Product Label from the electronic animal drug product listing directory.
  • Propofol SPL • Structured Product Label • Official
    FDA Structured Product Label from the electronic animal drug product listing directory.
  • PropoFlo 28 SPL • Structured Product Label • Official
    FDA Structured Product Label from the electronic animal drug product listing directory.
  • Rapanofal SPL • Structured Product Label • Official
    FDA Structured Product Label from the electronic animal drug product listing directory.
  • PropoFlo SPL • Structured Product Label • Official
    FDA Structured Product Label from the electronic animal drug product listing directory.
  • Rapanofal SPL • Structured Product Label • Official
    FDA Structured Product Label from the electronic animal drug product listing directory.
  • FOI Summary oA 200-793 Approved November 18, 2024.pdf • FOI summary • Official • Dec. 2, 2024
    FDA FOI summary for application 200793
  • UCM488658.pdf • FOI summary • Official • April 29, 2022
    FDA FOI summary for application 141070
  • ucm116781.pdf • FOI summary • Official • April 29, 2022
    FDA FOI summary for application 141070
  • UCM355533.pdf • FOI summary • Official • Dec. 18, 2017
    FDA FOI summary for application 141098
  • UCM248263.pdf • FOI summary • Official • Dec. 18, 2017
    FDA FOI summary for application 141098
  • UCM224476.pdf • FOI summary • Official • June 1, 2016
    FDA FOI summary for application 141303

Data Sources & Change Log

Every non-trivial field is expected to include provenance and update timestamps.

Official 131 Clinical 1 Manufacturer 0 Marketing 0
Current Field Facts
  • side_effects: Top reported reactions (openFDA): Death, Vomiting, Lack of efficacy - NOS, Bradycardia, Seizure NOS, Diarrhoea. (Clinical, 2026-04-11)
  • contraindications: Adequate data concerning safe use of propofol in pregnant and breeding cats have not been obtained. Doses may need adjustment for geriatric or debilitated pati… (Official, 2026-04-12)
  • contraindications: Adequate data concerning safe use of propofol in pregnant and breeding cats have not been obtained. Doses may need adjustment for geriatric or debilitated pati… (Official, 2026-04-11)
  • contraindications: Adequate data concerning safe use of propofol in pregnant and breeding cats have not been obtained. Doses may need adjustment for geriatric or debilitated pati… (Official, 2026-02-12)
  • indications: 1. The supplement supports the addition of a new species, cats, to the original approved dog application for the same anesthetic indications.2. The supplement … (Official, 2026-08-06)
  • indications: 1. The supplement supports the addition of a new species, cats, to the original approved dog application for the same anesthetic indications.2. The supplement … (Official, 2026-08-05)
  • indications: 1. The supplement supports the addition of a new species, cats, to the original approved dog application for the same anesthetic indications.2. The supplement … (Official, 2026-08-04)
  • indications: 1. The supplement supports the addition of a new species, cats, to the original approved dog application for the same anesthetic indications.2. The supplement … (Official, 2026-08-03)
  • indications: 1. The supplement supports the addition of a new species, cats, to the original approved dog application for the same anesthetic indications.2. The supplement … (Official, 2026-08-02)
  • indications: 1. The supplement supports the addition of a new species, cats, to the original approved dog application for the same anesthetic indications.2. The supplement … (Official, 2026-08-01)
  • indications: 1. The supplement supports the addition of a new species, cats, to the original approved dog application for the same anesthetic indications.2. The supplement … (Official, 2026-07-31)
  • indications: 1. The supplement supports the addition of a new species, cats, to the original approved dog application for the same anesthetic indications.2. The supplement … (Official, 2026-07-30)
  • indications: 1. The supplement supports the addition of a new species, cats, to the original approved dog application for the same anesthetic indications.2. The supplement … (Official, 2026-07-29)
  • indications: 1. The supplement supports the addition of a new species, cats, to the original approved dog application for the same anesthetic indications.2. The supplement … (Official, 2026-07-28)
  • indications: 1. The supplement supports the addition of a new species, cats, to the original approved dog application for the same anesthetic indications.2. The supplement … (Official, 2026-07-27)
  • indications: 1. The supplement supports the addition of a new species, cats, to the original approved dog application for the same anesthetic indications.2. The supplement … (Official, 2026-07-26)
  • indications: 1. The supplement supports the addition of a new species, cats, to the original approved dog application for the same anesthetic indications.2. The supplement … (Official, 2026-07-25)
  • indications: 1. The supplement supports the addition of a new species, cats, to the original approved dog application for the same anesthetic indications.2. The supplement … (Official, 2026-07-25)
  • indications: 1. The supplement supports the addition of a new species, cats, to the original approved dog application for the same anesthetic indications.2. The supplement … (Official, 2026-07-22)
  • indications: 1. The supplement supports the addition of a new species, cats, to the original approved dog application for the same anesthetic indications.2. The supplement … (Official, 2026-07-22)
Recent Revisions
  • side_effects updated 2026-04-12 10:05 by etl_backfill • Backfilled from existing medication fields
  • contraindications updated 2026-04-12 10:05 by etl_backfill • Backfilled from existing medication fields
  • usage updated 2026-04-12 10:05 by etl_backfill • Backfilled from existing medication fields
  • side_effects updated 2026-04-11 10:05 by etl_backfill • Backfilled from existing medication fields
  • contraindications updated 2026-04-11 10:05 by etl_backfill • Backfilled from existing medication fields
  • usage updated 2026-04-11 10:05 by etl_backfill • Backfilled from existing medication fields
  • side_effects updated 2026-02-12 22:44 by etl_backfill • Backfilled from existing medication fields
  • contraindications updated 2026-02-12 22:44 by etl_backfill • Backfilled from existing medication fields
  • usage updated 2026-02-12 22:44 by etl_backfill • Backfilled from existing medication fields

FDA Products & Applications (Animal Drugs @ FDA)

Official sponsor/proprietary-name/application-status records linked by active ingredient.

Product Sponsor Application Status Published
PropofolVet Multidose
RX
Propofol
Injectable emulsion • Intravenous
Label highlights
Official documents
Parnell Technologies Pty. Ltd. ANADA 200-793 Approved Dec 2, 2024
Rapanofal®
RX
Propofol
Liquid (Emulsion) • Intravenous
Label highlights
Official documents
IVAOES, INC. DBA IVAOES ANIMAL HEALTH NADA 141-070 Approved Apr 29, 2022
PropoFlo™ 28 PropoFlo™
RX
Propofol
Liquid (Emulsion) • Intravenous
Label highlights
Official documents
Zoetis Inc. NADA 141-098 Approved Dec 18, 2017
PropoClear™
RX
Propofol
Microemulsion • Intravenous
Label highlights
Official documents
Zoetis Inc. NADA 141-303 Approved Jun 1, 2016

Data source: FDA Animal Drugs @ FDA (public search export).

What It's For (FDA Label Highlights)

Extracted from FDA Animal Drugs @ FDA product labeling. Always confirm details with your veterinarian.

Composition / specifications
10 mg/mL propofol
Dogs
Indication

For induction of anesthesia. For maintenance of general anesthesia by intermittent bolus injections for short procedures. For induction of general anesthesia where maintenance is provided by inhalant anesthetics.

Dosage

For induction of general anesthesia without the use of preanesthetics, the dosage is 7.6 milligrams per kilogram titrated against the response of the patient over 60-90 seconds or until clinical signs show the onset of anesthesia (5.0 to 7.6 mg/kg/min).The use of preanesthetic medication reduces propofol dose requirements. For the maintenance of general anesthesia without the use of preanesthetics, the dosage is 3.2 milligrams per kilogram The use of preanesthetic medication reduces propofol dose requirements. Due to the rapid metabolism of propofol, additional low doses of propofol, similar to those used for maintenance with propofol, may be required to complete the transition to inhalant maintenance anesthesia.

Limitations

FDA page: Open in Animal Drugs @ FDA

Species: Dog • Cat
Composition / specifications
The drug is a sterile, nonpyrogenic, oil-in-water emulsion containing 10 milligrams of propofol per milliliter.
Cats
Indication
The drug is indicated for use as an anesthetic as follows: As a single injection to provide general anesthesia for short procedures, for induction and maintenance of general anesthesia using incremental doses to effect, and for induction of general anesthesia where maintenance is provided by inhalant anesthetics.
Dosage
The drug is administered by intravenous injection as follows: For induction of general anesthesia without the use of preanesthetics the dosage is 8.0 to 13.2 milligrams per kilogram (3.6 to 6.0 milligrams per pound). For the maintenance of general anesthesia without the use of preanesthetics the dosage is 1.1 to 4.4 milligrams per kilogram (0.5 to 2.0 milligrams per pound). The use of preanesthetic medication reduces propofol dose requirements.
Limitations
Adequate data concerning safe use of propofol in pregnant and breeding cats have not been obtained. Doses may need adjustment for geriatric or debilitated patients. Federal law restricts this drug to use by or on the order of a licensed veterinarian.
Dogs
Indication
The drug is indicated for use as an anesthetic as follows: As a single injection to provide general anesthesia for procedures lasting up to 5 minutes; for induction and maintenance of general anesthesia using incremental doses to effect; for induction of general anesthesia where maintenance is provided by inhalant anesthetics.
Dosage
The drug is administered by intravenous injection as follows: For induction of general anesthesia without the use of preanesthetics the dosage is 5.5 to 7.0 milligrams per kilogram (2.5 to 3.2 milligrams per pound); for the maintenance of general anesthesia without the use of preanesthetics the dosage is 1.1 to 3.3 milligrams per kilogram (0.5 to 1.5 milligrams per pound). The use of preanesthetic medication reduces propofol dose requirements.
Limitations
Adequate data concerning safe use of propofol in pregnant and breeding dogs have not been obtained. Doses may need adjustment for geriatric or debilitated patients.

FDA page: Open in Animal Drugs @ FDA

Species: Dog
Composition / specifications
Each mL contains 10 mg propofol.
Dogs
Indication
For induction of anesthesia. For maintenance of general anesthesia for up to 20 minutes. For induction of general anesthesia where maintenance is provided by inhalant anesthetics.
Dosage
For induction of general anesthesia without the use of preanesthetics, the dosage is 5.5 to 7.6 milligrams per kilogram (2.5 to 3.2 milligrams per pound)The use of preanesthetic medication reduces propofol dose requirements. For the maintenance of general anesthesia without the use of preanesthetics, the dosage is 2.2 to 3.2 milligrams per kilogram (0.5 to 1.5 milligrams per pound. The use of preanesthetic medication reduces propofol dose requirements.
Limitations
Federal (USA) law restricts this drug to use by or on the order of a licensed veterinarian. Administer by intravenous injection only. Rapid bolus administration (induction or maintenance) or accidental overdosage of propofol may cause undesirable cardiorespiratory depression including hypotension and oxygen desaturation. Respiratory arrest (apnea) could occur. When using propofol, dogs should be continuously monitored and facilities for the maintenance of a patent airway, artificial ventilation, and oxygen supplementation must be immediately available. The use of propofol in pregnant and breeding dogs has not been evaluated. Propofol crosses the placenta and, as with other general anesthetic agents, the administration of propofol may be associated with neonatal depression. Propofol has not been evaluated in dogs less than 10 weeks of age

FDA page: Open in Animal Drugs @ FDA

Species: Dog • Cat
Composition / specifications
Each mL contains 10 mg propofol.
Dogs
Indication
For the induction and maintenance of anesthesia and for induction followed by maintenance with an inhalant anesthetic.
Dosage
Induction of General Anesthesia in Dogs: Induction dose guidelines are 4.0 to 6.5 mg/kg in dogs that do not receive a preanesthetic, and 1.4 to 6.5 mg/kg in dogs that receive a preanesthetic. The mean PROPOCLEAR induction dose is reduced by 20 to 30% for dogs that receive a preanesthetic (dose sparing effect). Anesthesia is usually observed within 60 seconds after the end of the induction dose administration. Duration of anesthesia following the recommended induction dose is approximately 4 minutes without a preanesthetic and 4 to 11 minutes with a preanesthetic. Individual anesthesia times may vary. Maintenance of General Anesthesia in Dogs: Anesthesia can be maintained by administration of PROPOCLEAR using intermittent IV injections. For dogs, the duration of anesthesia following a PROPOCLEAR maintenance dose is approximately 3 to 5 minutes. Clinical response may vary, and is determined by the dose, the rate of administration, and the frequency of maintenance injections. The maintenance dose and frequency should be based on the patient’s response. Sighthounds may need lower maintenance doses of PROPOCLEAR, and the time between maintenance dose administration and for recovery may be longer.
Limitations
Federal law restricts this drug to use by or on the order of a licensed veterinarian. When using propofol, patients should be continuously monitored and facilities for the maintenance of a patient airway, artificial ventilation, and oxygen supplementation must be immediately available.
Cats
Indication
For the induction and maintenance of anesthesia and for induction followed by maintenance with an inhalant anesthetic.
Dosage
Induction of General Anesthesia in Cats: Induction dose guidelines are 4.1 to 8.0 mg/kg for cats that do not receive a preanesthetic, and 2.7 to 8.0 mg/kg for cats that receive a preanesthetic. The PROPOCLEAR induction dose is reduced by 16 to 24% for cats that receive a preanesthetic (dose sparing effect). Anesthesia is usually observed within 60 seconds after the end of the induction dose administration. Duration of anesthesia following the recommended induction dose is approximately 3 minutes without a preanesthetic and 3 to 6 minutes with a preanesthetic. Full standing recovery occurs within approximately 30 minutes in cats. Individual anesthesia times vary. The actual induction dose should be based on patient response. Maintenance of General Anesthesia in Cats: Anesthesia can be maintained by administration of PROPOCLEAR using intermittent IV injections. For cats, the duration of anesthesia following each PROPOCLEAR maintenance dose is approximately 3 to 5 minutes. Clinical response may vary, and is determined by the dose, rate of administration and frequency of maintenance injections. PROPOCLEAR maintenance dose sparing is greater in cats that receive a preanesthetic. The maintenance dose and frequency should be based on the patient’s response.
Limitations
Federal law restricts this drug to use by or on the order of a licensed veterinarian. When using propofol, patients should be continuously monitored and facilities for the maintenance of a patient airway, artificial ventilation, and oxygen supplementation must be immediately available.

FDA page: Open in Animal Drugs @ FDA

Usage

The drug is indicated for use as an anesthetic as follows: As a single injection to provide general anesthesia for short procedures, for induction and maintenance of general anesthesia using incremental doses to effect, and for induction of general anesthesia where maintenance is provided by inhalant anesthetics. The drug is indicated for use as an anesthetic as follows: As a single injection to provide general anesthesia for procedures lasting up to 5 minutes; for induction and maintenance of general anesthesia using incremental doses to effect; for induction of general anesthesia where maintenance is provided by inhalant anesthetics. For induction of anesthesia. For maintenance of general anesthesia for up to 20 minutes. For induction of general anesthesia where maintenance is provided by inhalant anesthetics.

Source: FDA Animal Drugs @ FDA • Reference

Contraindications

Adequate data concerning safe use of propofol in pregnant and breeding cats have not been obtained. Doses may need adjustment for geriatric or debilitated patients. Federal law restricts this drug to use by or on the order of a licensed veterinarian. Adequate data concerning safe use of propofol in pregnant and breeding dogs have not been obtained. Doses may need adjustment for geriatric or debilitated patients. Federal (USA) law restricts this drug to use by or on the order of a licensed veterinarian. Administer by intravenous injection only. Rapid bolus administration (induction or maintenance) or accidental overdosage of propofol may cause undesirable cardiorespiratory depression including hypotension and oxygen desaturation. Respiratory arrest (apnea) could occur. When using propofol, dogs should be continuously monitored and facilities for the maintenance of a patent airway, artificial ventilation, and oxygen supplementation must be immediately available. The use of propofol in pregnant and breeding dogs has not been evaluated. Propofol crosses the placenta and, as with other general anesthetic agents, the administration of propofol may be associated with neonatal depression. Propofol has not been evaluated in dogs less than 10 weeks of age

Top Reported Reactions (openFDA)

De-duplicated reaction terms grouped by body system from FDA openFDA reports (not verified; does not prove causation).

Digestive
Loss of appetite (1) • Dog Bloody diarrhoea (1) • Cat

Showing top 5 for Digestive.

Skin & allergy
Application site hair loss (1) • Cat

Showing top 5 for Skin & allergy.

Neurologic
Unsteady walking (1) • Cat

Showing top 5 for Neurologic.

Behavior
Behavioral disorder (1) • Cat Aggression (1) • Cat

Showing top 5 for Behavior.

Other
Cardiac disorder NOS (1) • Cat Cardiac arrest (1) • Dog Burn (1) • Dog Breathing difficulty (1) • Cat Bradycardia (1) • Cat
Show more (21)
Bloody stool (1) • Cat Bladder distension (1) • Cat Balance impaired (1) • Cat Bacterial skin infection NOS (1) • Dog Azotaemia (1) • Cat Ascites (1) • Cat Arthritis (1) • Cat Application site serous discharge (1) • Dog Anaphylaxis (1) • Cat Anaemia NOS (1) • Cat Administration error NOS (1) • Cat Adipsia (1) • Cat Acute renal failure (1) • Cat Acting tense (1) • Cat Acid-base disorder (1) • Dog Abnormal radiograph finding (1) • Dog Abnormal posture NOS (1) • Cat Abnormal electrocardiogram (1) • Dog Abnormal cytology (1) • Dog Abdominal discomfort (1) • Dog Abdominal cavity disorder NOS (1) • Dog

Showing top 5 for Other.

Data source: FDA openFDA Animal & Veterinary adverse event reports.

Adverse Event Case Summaries (openFDA)

These are individual FDA adverse event reports. They are unverified and do not prove the medication caused the reaction.

Dog, Spaniel - King Charles Cavalier, Female, 7 year, 9.48 kilogram • Drug: MSK, Emulsion, Intravenous, Dose: 4 mL per animal • Reactions: Cyanosis, Respiratory arrest, Premature ventricular contractions, Death • Outcome: Died

  • Report ID: USA-USFDACVM-2026-US-014468
  • Serious AE: Yes
  • Treated For AE: Yes
  • Sex: Female
  • Age: 7.00 Year
  • Weight: 9.480 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Intravenous
  • Form: Emulsion
  • Dose: 4 mL per animal
Reactions Reported:
Cyanosis Respiratory arrest Premature ventricular contractions Death
Outcomes: Died

Dog, ['Mastiff (unspecified)', 'Crossbred Canine/dog'], Male, 1 year, 29.574 kilogram • Drug: MSK, Emulsion, Intravenous, Dose: 11.80 mL per animal • Reactions: Hypotension, Not eating, Nausea, Drowsiness - systemic disorder, Pain NOS… • Outcome: Euthanized

  • Report ID: USA-USFDACVM-2026-US-014066
  • Serious AE: Yes
  • Treated For AE: Yes
  • Sex: Male
  • Age: 1.00 Year
  • Weight: 29.574 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Intravenous
  • Form: Emulsion
  • Dose: 11.80 mL per animal
Reactions Reported:
Hypotension Not eating Nausea Drowsiness - systemic disorder Pain NOS Vomiting Regurgitation Discoloured urine Cough Crust Hyperproteinaemia Hypoalbuminaemia Leukocytosis NOS Neutrophilia Fluid in abdomen NOS Septicaemia Intestinal disorder NOS Abdominal cavity disorder NOS Elevated lactate Abnormal cytology Duodenal ulcer Intestinal perforation Death by euthanasia Lack of efficacy - NOS Intentional misuse
Outcomes: Euthanized

Cat, Ragdoll, Male, 10 year, 5.498 kilogram • Drug: MSK, Unknown • Reactions: Head tilt - neurological disorder, Unsteady walking (ataxia) • Outcome: Outcome Unknown

  • Report ID: USA-USFDACVM-2026-US-014107
  • Serious AE: No
  • Treated For AE: No
  • Sex: Male
  • Age: 10.00 Year
  • Weight: 5.498 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Unknown
Reactions Reported:
Head tilt - neurological disorder Unsteady walking (ataxia)
Outcomes: Outcome Unknown

Cat, Domestic Shorthair, Female, 11 year, 5.33 kilogram • Drug: MSK, Unknown • Reactions: Dysphoria, Behavioral disorder (unspecified), Dilated pupils, Loss of appetite, Skin and tissue infection NOS… • Outcome: Recovered/Normal

  • Report ID: USA-USFDACVM-2026-US-013633
  • Serious AE: No
  • Treated For AE: Yes
  • Sex: Female
  • Age: 11.00 Year
  • Weight: 5.330 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Unknown
Reactions Reported:
Dysphoria Behavioral disorder (unspecified) Dilated pupils Loss of appetite Skin and tissue infection NOS Tiredness (lethargy)
Outcomes: Recovered/Normal

Cat, Persian, Male, 4 year, 4.08 kilogram • Drug: MSK, Unknown • Reactions: Laboured breathing, Loss of appetite • Outcome: Recovered/Normal

  • Report ID: USA-USFDACVM-2026-US-013262
  • Serious AE: Yes
  • Treated For AE: Yes
  • Sex: Male
  • Age: 4.00 Year
  • Weight: 4.080 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Unknown
Reactions Reported:
Laboured breathing Loss of appetite
Outcomes: Recovered/Normal

Dog, Retriever - Labrador, Female, 7 year, 29.211 kilogram • Drug: MSK, Unassigned, Unknown • Reactions: Unsteady walking (ataxia), Hind limb paresis, Proprioception deficit, Pain NOS, Partial lack of efficacy • Outcome: Ongoing

  • Report ID: USA-USFDACVM-2026-US-012958
  • Serious AE: Yes
  • Treated For AE: Yes
  • Sex: Female
  • Age: 7.00 Year
  • Weight: 29.211 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Unknown
  • Form: Unassigned
Reactions Reported:
Unsteady walking (ataxia) Hind limb paresis Proprioception deficit Pain NOS Partial lack of efficacy
Outcomes: Ongoing

Cat, Domestic Shorthair, Female, 7 year, 4.354 kilogram • Drug: MSK, Intravenous • Reactions: Drooling, Reluctant to move, Not eating, Dilated pupils, Not himself/herself… • Outcome: Died

  • Report ID: USA-USFDACVM-2026-US-014092
  • Serious AE: Yes
  • Treated For AE: Yes
  • Sex: Female
  • Age: 7.00 Year
  • Weight: 4.354 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Intravenous
Reactions Reported:
Drooling Reluctant to move Not eating Dilated pupils Not himself/herself Hypothermia Tachypnoea Intentional misuse Leukopenia NOS Hypoglycaemia Elevated symmetrical dimethylarginine Azotaemia Low ionized calcium Obtunded Weak pulse Lateral recumbency Regurgitation Cardiac arrest Death
Outcomes: Died

Cat, Siamese, Male, 1 year, 4.763 kilogram • Drug: MSK, Injection, emulsion, Intravenous, Dose: 1 Unknown per unknown • Reactions: Anaphylaxis, Vomiting, Bloody stool, Tiredness (lethargy), Hypothermia… • Outcome: Ongoing

  • Report ID: USA-USFDACVM-2026-US-013383
  • Serious AE: Yes
  • Treated For AE: No
  • Sex: Male
  • Age: 1.00 Year
  • Weight: 4.763 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Intravenous
  • Form: Injection, emulsion
  • Dose: 1 Unknown per unknown
Reactions Reported:
Anaphylaxis Vomiting Bloody stool Tiredness (lethargy) Hypothermia Elevated alanine aminotransferase Elevated blood urea nitrogen Hyperphosphataemia Leukocytosis NOS Elevated total bilirubin
Outcomes: Ongoing

Data source: FDA openFDA Animal & Veterinary adverse event reports.

Overdose Information

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