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Roxee Medication Guide

Bedinvetmab

Medication reference facts with explicit FDA-approval, off-label, source-limited, and safety context. Roxee does not sell, prescribe, or dispense medications.

Both Reference complete FDA data linked Rx required Injection Zoetis Inc. Official label facts Owner quick guide first
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Data freshness

Reference facts
Reference refreshed
Jun 22, 2026, 10:41 a.m.

These are the reference facts Roxee uses on browse cards and quick facts.

FDA applications
FDA application data refreshed
Jun 22, 2026, 10:41 a.m.

Sponsor, product, and application records imported from Animal Drugs @ FDA.

Safety reports
Safety data refreshed
Jun 22, 2026, 10:42 a.m.

openFDA reaction terms and case summaries are supporting evidence, not proof of causality.

Source timing details
Source timing details
  • Reference facts: Source Roxee | Refreshed Jun 22, 2026, 10:41 AM UTC
    The reference fact projection used for browse cards and quick facts.
  • Animal Drugs @ FDA: Source FDA | Refreshed Jun 22, 2026, 10:40 AM UTC
    Applications/products are imported from FDA export data.
  • Animal Drugs @ FDA previews: Source FDA | Refreshed Feb 9, 2026, 3:05 AM UTC
    Label highlights/doc links are fetched from FDA preview endpoints.
  • Animal Drug Product Listing Directory (NDC): Source FDA | Refreshed Jun 22, 2026, 10:41 AM UTC
    Package/product NDCs from FDA’s electronic listing directory (XLS).
  • openFDA reaction terms: Source FDA openFDA | Refreshed Jun 22, 2026, 10:45 AM UTC
  • openFDA case summaries: Source FDA openFDA | Refreshed Jun 22, 2026, 10:45 AM UTC
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Bedinvetmab

Bedinvetmab

Drug type: Generic ingredient • Branded profile • FDA branded products available

Both Injection Rx required 100% reference complete

Species: Both

Manufacturer: Zoetis Inc.

Medication Snapshot

Merged from the current Roxee medication system with field-level provenance, freshness, and completeness tracking.

Bedinvetmab

For the control of pain associated with osteoarthritis in dogs. Species commonly shown: Both, Dog.

Generic name
Bedinvetmab
Brand names
Librela™, Librela
Manufacturer
Zoetis Inc.
Species
Both, Dog
Dosage forms
Injection, Injectable Solution
Prescription
Prescription required
Completeness
100%
Validation
Complete
Brand names
Librela™ Librela
Dosage forms
Injection Injectable Solution

Indications / Uses

For the control of pain associated with osteoarthritis in dogs.

Side Effects

Top reported reactions (openFDA): Death by euthanasia, Lethargy (see also Central nervous system depression in Neurological), Polydipsia, Ataxia, Vomiting, Polyuria.

FAQ

Both, Dog

Yes. Roxee shows this as prescription-only.

Injection, Injectable Solution

Related Medications

Carprofen Same category: Pain & Arthritis Deracoxib Same category: Pain & Arthritis Gabapentin Same category: Pain & Arthritis Grapiprant Same category: Pain & Arthritis Meloxicam Same category: Pain & Arthritis Robenacoxib Same category: Pain & Arthritis

Related Conditions

Osteoarthritis (Degenerative Joint Disease) Osteoarthritis (Degenerative Joint Disease) Pain (acute, chronic)

Source Transparency

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Pet Owner Quick Guide

Start here first for the safest next-step summary before the deeper medication detail.

Used for:

For the control of pain associated with osteoarthritis in dogs.

Dosing note:

Exact dosing depends on your pet's species, weight, and health status. Use your veterinarian's instructions for the exact dose and schedule.

What to watch for:

  • wobbly/unsteady walking (1 reports)
  • Loss of appetite (1 reports)
  • Circling - neurological disorder (1 reports)

When to call the vet:

  • Repeated vomiting or diarrhea.
  • Severe lethargy (hard to wake, very low energy).
  • Collapse or fainting.
  • Trouble breathing.
  • Facial swelling or hives.
  • Blood in vomit or stool.

What to tell or ask your vet today:

  • Is this medicine the right fit for my pet’s current symptoms?
  • Which warning signs mean I should call back right away?
  • How should I handle missed doses or refusal to take the medicine?

Next actions

Talk to a Vet / Find a Vet Near You Save to pet meds Share page Review report evidence
Research brief

Medication Research Insights

A source-aware map of what to know, what is uncertain, and what to verify with your veterinarian.

Source Backed Signals

What to know

Evidence-backed context Limited

Roxee has limited cited overview evidence for Bedinvetmab; use the official documents and your veterinarian's instructions for product-specific decisions.

Source: openFDA case USA-USFDACVM-2024-US-016089
Safety signal coverage Reported signals

32 tracked reaction signals; 32 reported cases; 23 serious reports; 2 species groups. These are reporting and label-derived signals for interpretation with a veterinarian.

Source: openFDA case USA-USFDACVM-2024-US-016089
Interpretation guardrail Not causation

Adverse-event reports help form a watch list, but they do not prove the medication caused the reaction and they are not a risk ranking between medications.

Evidence tension

Stronger signal Label / review

Official labels, package inserts, and reviewed summaries carry more weight than isolated reports.

Source: openFDA case USA-USFDACVM-2024-US-016089
Weaker signal Reported data

Case reports and openFDA terms are useful for pattern awareness, but they are incomplete, can include multiple exposures, and do not estimate an individual pet's probability of harm.

Reaction signal map

Most reported reactions Top terms

Unsteady walking (ataxia) (1 reports), Loss of appetite (1 reports), Circling - neurological disorder (1 reports), Chewing disorder (1 reports), Cartilage degeneration (1 reports)

Body systems represented Signal grouping

Digestive (2), Skin & allergy (2), Neurologic (2), Behavior (3)

Explore supporting adverse reports

Species and breed lens

Species represented in reports Species lens

Dog (30 reports), Cat (2 reports)

Breed metadata in reports Metadata only

Shepherd Dog - German (1), Corgi (unspecified) (1), Shepherd Dog - Australian (1), Chihuahua (1). These are report metadata, not proof that a breed is at higher risk.

What your vet may verify

Fit for this patient Vet check

Verify whether Bedinvetmab fits the pet's species, current diagnosis, age, weight, organ status, pregnancy/lactation status, and concurrent medications.

Evidence limitations Evidence review

Separate label-backed warnings from adverse-event reports and owner observations before changing the plan.

What to watch next

Watch list Owner-safe

wobbly/unsteady walking, Loss of appetite, Circling - neurological disorder

Call sooner if Escalation

Repeated vomiting or diarrhea. Severe lethargy (hard to wake, very low energy). Collapse or fainting.

Bottom line: Use this Bedinvetmab brief as a structured watch list and source map, not as a reason to start, stop, or change treatment without your veterinarian.
Vet source depth
  1. openFDA case USA-USFDACVM-2024-US-016089 · adverse_reaction · adverse reactions
  2. FDA application profile · official_label · quick facts
  3. Medication usage source · fda_animal_drugs · quick facts
  4. FOI · document · documents
  5. Labeling · document · documents
  6. SPL · document · documents
  7. Structured Product Label · document · documents

Evidence

Review status / Updated / Sources

Review status: Clinical reviewer not listed

Updated: February 12, 2026, 10:44 PM UTC

Sources:
Safety & side effects

Side effects to monitor:

  • wobbly/unsteady walking
  • Loss of appetite
  • Circling - neurological disorder

Most reported reactions:

  • Unsteady walking (ataxia) (1 reports)
  • Loss of appetite (1 reports)
  • Circling - neurological disorder (1 reports)
Explore reported case details

Emergency warning signs:

  • Repeated vomiting or diarrhea.
  • Severe lethargy (hard to wake, very low energy).
  • Collapse or fainting.
  • Trouble breathing.
Talk to a Vet / Find a Vet Near You Start Symptom Intake

Vet Fast Scan

Source-backed clinical checkpoints for quick review.

FDA-labeled species
Dog
Indication / use
For the control of pain associated with osteoarthritis in dogs.
Form / route / dose
Form: Injectable Solution
Route: Subcutaneous
Confirm product label and patient-specific plan.
Warnings
No structured warnings linked yet.
Adverse-event caveat
openFDA adverse-event cases are reported signals. They are not verified, do not prove causation, and do not estimate a pet's individual risk.
Source docs

Quick Facts

Official label facts first, then secondary summaries. Marketing content is separated below.

Species: Both
Manufacturer: Zoetis Inc.
Form: Injectable Solution
Identifiers:
NADA: 141562 NDC Package: 54771-2772-1 NDC Package: 54771-2772-2 NDC Package: 54771-2778-1 NDC Package: 54771-2778-2 NDC Package: 54771-2779-1 NDC Package: 54771-2779-2 NDC Package: 54771-2780-1 NDC Package: 54771-2780-2 NDC Package: 54771-2781-1 NDC Package: 54771-2781-2 NDC Product: 54771
Source metadata:

Adverse Reactions

Snapshot first, detailed rows second. This section summarizes signal data and is not a diagnosis.

Reported case explorer

Filter stored openFDA reports by pet and report attributes. Counts describe reports in this data set, not risk.

Clear filters
openFDA adverse-event cases are reported signals. They are not verified, do not prove causation, and do not estimate a pet's individual risk.
Stored reports
76
Matching reports
70
Active filters
1
Selected filters
Body system: Other Clear
Reset
Drill into common report signals
Lethargy (see also Central nervous system depression in Neurological) (15) Seizure NOS (12) Medication error NOS (10) Urinary incontinence (10) Other (70) Neurologic (39) Digestive (23) Effectiveness (14)
Showing up to 50 matching reports. Narrow filters to inspect the remaining reports.

USA-USFDACVM-2025-US-075421

Received 2025-12-29 · MSK · MSK

Serious
Species
Dog
Breed
Shepherd Dog - German
Size / weight
25-49 lb (20.865 Kilogram)
Age
8+ years (11 Year)
Sex
Female Unknown
Region
USA
Reactions
Emesis (multiple)Not eatingLethargy (see also Central nervous system depression in Neurological)Reluctant to moveSeizure NOS
Body systems
DigestiveOtherNeurologic
Outcomes
Ongoing

USA-USFDACVM-2025-US-075346

Received 2025-12-29 · MSK · MSK

Non-serious
Species
Dog
Breed
Corgi (unspecified)
Size / weight
25-49 lb (12.156 Kilogram)
Age
8+ years (11 Year)
Sex
Male Neutered
Region
USA
Reactions
Proprioception deficitLumbar painFallingDifficulty to riseDecreased activityGeneral illness
Body systems
Other
Outcomes
Ongoing

USA-USFDACVM-2025-US-075198

Received 2025-12-29 · MSK · MSK

Non-serious
Species
Dog
Breed
Shepherd Dog - Australian
Size / weight
50-99 lb (23.133 Kilogram)
Age
8+ years (12 Year)
Sex
Female Unknown
Region
USA
Reactions
TremblingAtaxiaPantingUrinary incontinence
Body systems
OtherNeurologic
Outcomes
Recovered/Normal

USA-USFDACVM-2025-US-075262

Received 2025-12-27 · MSK · MSK

Serious
Species
Dog
Breed
Chihuahua
Size / weight
Under 10 lb (3.084 Kilogram)
Age
8+ years (12 Year)
Sex
Male Unknown
Region
USA
Reactions
Seizure NOSLateral recumbencyUnresponsive to stimuliBradycardia
Body systems
NeurologicOther
Outcomes
Recovered/Normal

USA-USFDACVM-2025-US-075344

Received 2025-12-26 · MSK · MSK

Non-serious
Species
Dog
Breed
Dog (unknown)
Sex
Female Unknown
Region
USA
Reactions
Unable to walk
Body systems
Other
Outcomes
Outcome Unknown

USA-USFDACVM-2025-US-075395

Received 2025-12-23 · MSK · MSK

Serious
Species
Dog
Breed
['Retriever (unspecified)', 'Dog (unknown)']
Size / weight
50-99 lb (30.754 Kilogram)
Age
8+ years (12 Year)
Sex
Male Neutered
Region
USA
Reactions
Not eatingWobblinessLethargy (see also Central nervous system depression in Neurological)
Body systems
OtherNeurologic
Outcomes
Ongoing

USA-USFDACVM-2025-US-075264

Received 2025-12-23 · MSK · MSK

Serious
Species
Dog
Breed
Retriever - Labrador
Size / weight
50-99 lb (37.467 Kilogram)
Age
8+ years (14 Year)
Sex
Male Neutered
Region
USA
Reactions
Lethargy (see also Central nervous system depression in Neurological)Urinary incontinenceUnable to standFaecal incontinenceNot eatingNot drinkingDifficulty going up/down stairsLimb weaknessBumping into wallsRecumbencyDeath
Body systems
NeurologicOther
Outcomes
Died

USA-USFDACVM-2025-US-075205

Received 2025-12-23 · MSK · MSK

Serious
Species
Dog
Breed
Weimaraner
Size / weight
100+ lb (58.513 Kilogram)
Age
8+ years (9 Year)
Sex
Male Neutered
Region
USA
Reactions
Lack of efficacy - NOSMusculoskeletal disorder NOS
Body systems
EffectivenessOther
Outcomes
Ongoing

USA-USFDACVM-2025-US-075140

Received 2025-12-23 · MSK · MSK

Serious
Species
Dog
Breed
Shepherd Dog - German
Size / weight
50-99 lb (40.37 Kilogram)
Age
8+ years (11 Year)
Sex
Female Unknown
Region
USA
Reactions
Partial lack of efficacySwollen feetPolyarthritisLocalised pain NOS (see other SOCs for specific pain)Swollen jointJoint pain
Body systems
EffectivenessOther
Outcomes
Ongoing

USA-USFDACVM-2025-US-075305

Received 2025-12-22 · MSK · MSK

Non-serious
Species
Dog
Breed
Bulldog - English
Size / weight
50-99 lb (29.94 Kilogram)
Age
8+ years (11.2 Year)
Sex
Female Unknown
Region
USA
Reactions
Urinary incontinence
Body systems
Other
Outcomes
Ongoing

USA-USFDACVM-2025-US-075189

Received 2025-12-22 · MSK · MSK

Serious
Species
Dog
Breed
['Retriever - Golden', 'Beagle', 'Chow Chow']
Size / weight
25-49 lb (19.504 Kilogram)
Age
8+ years (11 Year)
Sex
Male Neutered
Region
USA
Reactions
AtaxiaVestibular disorder NOSWeight lossHead tilt - neurological disorder (see also Head tilt - ear disorder)Low visionUrinary incontinenceUnable to riseUrinary tract infectionPolydipsiaHorizontal nystagmusGeneralised weaknessDepression
Body systems
NeurologicOther
Outcomes
Ongoing

USA-USFDACVM-2025-US-075413

Received 2025-12-19 · MSK · MSK

Serious
Species
Dog
Breed
Crossbred Canine/dog
Size / weight
50-99 lb (30.119 Kilogram)
Age
8+ years (12 Year)
Sex
Male Neutered
Region
USA
Reactions
Not eatingVomitingLymphadenopathyHalitosisLow platelet countElevated alanine aminotransferase (ALT)Elevated serum alkaline phosphatase (ALP)Anxiety
Body systems
OtherDigestiveBehavior
Outcomes
Ongoing

USA-USFDACVM-2025-US-075362

Received 2025-12-19 · MSK · MSK

Non-serious
Species
Dog
Breed
['Retriever - Labrador', 'Mastiff (unspecified)']
Size / weight
100+ lb (57.606 Kilogram)
Age
8+ years (8 Year)
Sex
Male Neutered
Region
USA
Reactions
FallingLateral recumbencyVomiting
Body systems
OtherDigestive
Outcomes
Ongoing

USA-USFDACVM-2025-US-075270

Received 2025-12-19 · MSK · MSK

Serious
Species
Dog
Breed
['Pointer (unspecified)', 'Dog (unknown)']
Size / weight
50-99 lb (35.698 Kilogram)
Age
8+ years (15 Year)
Sex
Male Neutered
Region
USA
Reactions
Lack of efficacy - NOSDeathLocal erythemaUnderdoseLethargy (see also Central nervous system depression in Neurological)Blood in vomit
Body systems
EffectivenessOtherNeurologicDigestive
Outcomes
Died

USA-USFDACVM-2025-US-074497

Received 2025-12-19 · MSK · MSK

Non-serious
Species
Dog
Breed
['Terrier - Scottish', 'Dog (unknown)']
Size / weight
10-24 lb (11.249 Kilogram)
Age
8+ years (16 Year)
Sex
Male Neutered
Region
USA
Reactions
RestlessnessStaringConfusionDifficulty eating NOSAnxietyElevated blood urea nitrogen (BUN)Elevated serum alkaline phosphatase (ALP)
Body systems
OtherBehavior
Outcomes
Ongoing

USA-USFDACVM-2025-US-074272

Received 2025-12-18 · MSK · MSK

Serious
Species
Dog
Breed
['Terrier (unspecified)', 'Dog (unknown)']
Size / weight
10-24 lb (9.072 Kilogram)
Age
8+ years (14 Year)
Sex
Male Intact
Region
USA
Reactions
DeathSeizure NOSRenal failureAnaemia NOSAnorexiaSleepiness - systemic disorderConfusionShakingUnable to riseBumping into wallsCorneal ulcerIncreased drinkingSquintingOcular dischargeBiting -aggression (see also Skin and appendages disorders)Elevated alanine aminotransferase (ALT)Medication error NOSGeneral illness
Body systems
OtherNeurologicDigestiveBehavior
Outcomes
Died

USA-USFDACVM-2025-US-074070

Received 2025-12-18 · MSK · MSK

Serious
Species
Dog
Breed
['Retriever - Golden', 'Poodle (unspecified)']
Size / weight
50-99 lb (43.273 Kilogram)
Age
8+ years (12 Year)
Sex
Female Unknown
Region
USA
Reactions
Urinary tract infectionMedication error NOSLack of efficacy - NOS
Body systems
OtherEffectiveness
Outcomes
Ongoing

USA-USFDACVM-2025-US-074412

Received 2025-12-17 · MSK · MSK

Non-serious
Species
Dog
Breed
['Shepherd Dog - German', 'Siberian Husky']
Size / weight
50-99 lb (35.063 Kilogram)
Age
8+ years (14 Year)
Sex
Male Neutered
Region
USA
Reactions
Sleep disturbance NOSAnxietyPanting
Body systems
OtherBehavior
Outcomes
Ongoing

USA-USFDACVM-2025-US-074392

Received 2025-12-17 · MSK · MSK

Non-serious
Species
Dog
Breed
['Shepherd Dog - German', 'Siberian Husky']
Size / weight
50-99 lb (34.019 Kilogram)
Age
8+ years (9 Year)
Sex
Female Unknown
Region
USA
Reactions
Difficulty going up/down stairsLying downHigh leg gait
Body systems
Other
Outcomes
Outcome Unknown

USA-USFDACVM-2025-US-074330

Received 2025-12-17 · MSK · MSK

Serious
Species
Dog
Breed
['Retriever - Labrador', 'Dog (unknown)']
Size / weight
50-99 lb (45.359 Kilogram)
Age
8+ years (10.5 Year)
Sex
Female Unknown
Region
USA
Reactions
ArthritisLack of efficacy - NOSElevated serum alkaline phosphatase (ALP)Elevated alanine aminotransferase (ALT)HyperglycaemiaOverdoseMedication error NOS
Body systems
OtherEffectiveness
Outcomes
Ongoing

USA-USFDACVM-2025-US-074601

Received 2025-12-16 · MSK · MSK

Serious
Species
Dog
Breed
Retriever - Labrador
Size / weight
50-99 lb (39.463 Kilogram)
Age
4-7 years (5 Year)
Sex
Male Neutered
Region
USA
Reactions
Limb non-weight bearingBone and joint disorder NOSOther abnormal test result NOSAbnormal radiograph findingUrinary tract obstruction/blockageDiscomfort NOSWalking difficultyDeath by euthanasiaOsteochondritis dissecansUrolithiasis
Body systems
Other
Outcomes
Euthanized

USA-USFDACVM-2025-US-074579

Received 2025-12-16 · MSK · MSK

Non-serious
Species
Dog
Breed
['Pointing Dog - Hungarian Short-haired (Vizsla)', 'Dog (unknown)']
Size / weight
25-49 lb (19.731 Kilogram)
Age
8+ years (14 Year)
Sex
Female Unknown
Region
USA
Reactions
WeaknessNot eatingGlazed eye
Body systems
Other
Outcomes
Ongoing

USA-USFDACVM-2025-US-074459

Received 2025-12-16 · MSK · MSK

Serious
Species
Dog
Breed
Retriever - Labrador
Size / weight
50-99 lb (33.339 Kilogram)
Age
8+ years (8 Year)
Sex
Female Unknown
Region
USA
Reactions
Immune mediated haemolytic anaemiaDeathAnaemia NOSThrombocytopeniaNeutrophiliaHeart murmurVomitingIcterusPantingNot eatingOther abnormal test result NOSElevated alanine aminotransferase (ALT)Elevated total bilirubinElevated serum alkaline phosphatase (ALP)ThrombocytosisHaemolysis NOSMedication error NOSMonocytosisLarge plateletsSpherocytosisAgglutination test, positive
Body systems
OtherDigestive
Outcomes
Died

USA-USFDACVM-2025-US-074352

Received 2025-12-16 · MSK · MSK

Serious
Species
Dog
Breed
Siberian Husky
Size / weight
50-99 lb (30.16 Kilogram)
Age
8+ years (11 Year)
Sex
Male Neutered
Region
USA
Reactions
PolyuriaPolydipsiaSkin discolouration NOSPoor coat conditionComplication of diabetesElevated thyroxine (T4)Elevated cholesterol (total)Partial lack of efficacyWeight gain
Body systems
OtherEffectiveness
Outcomes
Ongoing

USA-USFDACVM-2025-US-074109

Received 2025-12-16 · MSK · MSK

Serious
Species
Dog
Breed
['Retriever - Labrador', 'Dog (unknown)']
Size / weight
50-99 lb (26.308 Kilogram)
Age
8+ years (12 Year)
Sex
Female Unknown
Region
USA
Reactions
Stiff gaitLimb weaknessUnable to walkHind limb ataxiaKnucklingParaparesis
Body systems
OtherNeurologic
Outcomes
Ongoing

USA-USFDACVM-2025-US-074255

Received 2025-12-15 · MSK · MSK

Non-serious
Species
Dog
Breed
Terrier - Jack Russell
Size / weight
10-24 lb (6.214 Kilogram)
Age
8+ years (13 Year)
Sex
Female Unknown
Region
USA
Reactions
Inappropriate elimination NOSProprioception deficitWeight lossVomitingDiarrhoeaProteinuriaElevated globulinsNeutrophiliaAbnormal radiograph finding
Body systems
OtherDigestive
Outcomes
Ongoing

USA-USFDACVM-2025-US-074110

Received 2025-12-15 · MSK · MSK

Serious
Species
Dog
Breed
['Retriever - Labrador', 'Dog (unknown)']
Size / weight
50-99 lb (26.76 Kilogram)
Age
8+ years (14 Year)
Sex
Female Unknown
Region
USA
Reactions
Skin ulcerBacterial skin infection NOSLack of efficacy (bacteria) - NOS
Body systems
OtherEffectiveness
Outcomes
Ongoing

USA-USFDACVM-2025-US-074064

Received 2025-12-15 · MSK · MSK

Serious
Species
Dog
Breed
['Bichon Frise', 'Chihuahua']
Size / weight
Under 10 lb (3.493 Kilogram)
Age
8+ years (15 Year)
Sex
Female Unknown
Region
USA
Reactions
Seizure NOSAtaxiaUrinary incontinence
Body systems
NeurologicOther
Outcomes
Ongoing

USA-USFDACVM-2025-US-073880

Received 2025-12-15 · MSK · MSK

Serious
Species
Dog
Breed
['Retriever - Labrador', 'Dog (unknown)']
Size / weight
50-99 lb (28.304 Kilogram)
Age
8+ years (11 Year)
Sex
Female Intact
Region
USA
Reactions
DeathLethargy (see also Central nervous system depression in Neurological)Emesis (multiple)
Body systems
OtherNeurologicDigestive
Outcomes
Died

USA-USFDACVM-2025-US-072759

Received 2025-12-15 · MSK · MSK

Serious
Species
Dog
Breed
Weimaraner
Size / weight
50-99 lb (34.019 Kilogram)
Age
8+ years (12 Year)
Sex
Female Unknown
Region
USA
Reactions
RecumbencyLimb weaknessReduced reflexesProprioception deficitHind limb paresis
Body systems
Other
Outcomes
Ongoing

USA-USFDACVM-2025-US-072926

Received 2025-12-12 · MSK · MSK

Serious
Species
Dog
Breed
['Chihuahua', 'Dachshund (unspecified)']
Size / weight
10-24 lb (4.763 Kilogram)
Age
8+ years (18 Year)
Sex
Male Neutered
Region
USA
Reactions
Seizure NOSMedication error NOSOverdose
Body systems
NeurologicOther
Outcomes
Ongoing

USA-USFDACVM-2025-US-072922

Received 2025-12-12 · MSK · MSK

Serious
Species
Dog
Breed
Terrier - Bull - American Pit
Size / weight
50-99 lb (28.894 Kilogram)
Age
8+ years (13 Year)
Sex
Male Intact
Region
USA
Reactions
Pain NOSUrinary incontinenceLethargy (see also Central nervous system depression in Neurological)AnorexiaDeath
Body systems
OtherNeurologicDigestive
Outcomes
Died

USA-USFDACVM-2025-US-074245

Received 2025-12-10 · MSK · MSK

Serious
Species
Dog
Breed
['Hound (unspecified)', 'Dog (unknown)']
Size / weight
50-99 lb (35.83 Kilogram)
Age
8+ years (14.5 Year)
Sex
Male Neutered
Region
USA
Reactions
Aspiration pneumoniaLack of efficacy - NOSMedication error NOSAnaemia NOSMass NOSSkin ulcerUrine leakageLimb weaknessProprioception deficitWalking difficultyBarkingAnxietyUrinary tract infectionDiarrhoeaCoughPain NOS
Body systems
OtherEffectivenessBehaviorDigestive
Outcomes
Ongoing

USA-USFDACVM-2025-US-072884

Received 2025-12-10 · MSK · MSK

Serious
Species
Dog
Breed
['Pointer (unspecified)', 'Collie - Border']
Size / weight
50-99 lb (22.68 Kilogram)
Age
8+ years (15 Year)
Sex
Female Unknown
Region
USA
Reactions
AnxietyVocalisationBehavioural disorder NOSDiarrhoeaBiting -aggression (see also Skin and appendages disorders)PacingFrequent urinationInappropriate defecationInappropriate urinationCognitive disorder NOSSeizure NOSVocalizing while sleepingUnconsciousNystagmusDifficulty standingUnable to walkVestibular disorder NOSLimb non-weight bearingFallingUrinary incontinenceMedication error NOSPantingAbnormal posture NOS
Body systems
BehaviorOtherDigestiveNeurologic
Outcomes
Outcome Unknown

USA-USFDACVM-2025-US-072782

Received 2025-12-10 · MSK · MSK

Serious
Species
Dog
Breed
['Shepherd (unspecified)', 'Dog (unknown)']
Size / weight
25-49 lb (22.498 Kilogram)
Age
8+ years (11 Year)
Sex
Female Unknown
Region
USA
Reactions
Vestibular disorder NOSWobblinessHorizontal nystagmusHead tilt - neurological disorder (see also Head tilt - ear disorder)NauseaVomitingLack of efficacy - NOSOverdose
Body systems
OtherNeurologicDigestiveEffectiveness
Outcomes
Ongoing

USA-USFDACVM-2025-US-074653

Received 2025-12-09 · MSK · MSK

Serious
Species
Dog
Breed
['Pit Bull', 'Dog (unknown)']
Size / weight
50-99 lb (37.376 Kilogram)
Age
8+ years (11.5 Year)
Sex
Female Neutered
Region
USA
Reactions
Joint swellingBone and joint disorder NOSSarcoma NOS
Body systems
Skin & allergyOther
Outcomes
Ongoing

USA-USFDACVM-2025-US-073005

Received 2025-12-08 · MSK · MSK

Serious
Species
Dog
Breed
['Bichon Frise', 'Poodle - Miniature']
Size / weight
10-24 lb (8.21 Kilogram)
Age
8+ years (16 Year)
Sex
Female Unknown
Region
USA
Reactions
WeaknessLethargy (see also Central nervous system depression in Neurological)Unable to standUrine leakageAnaemia NOSElevated creatinineDistension of abdomenCoughPale mucous membraneTachypnoeaShiveringDeathElevated temperature
Body systems
OtherNeurologic
Outcomes
Died

USA-USFDACVM-2025-US-072836

Received 2025-12-08 · MSK · MSK

Non-serious
Species
Dog
Breed
Chihuahua
Size / weight
Under 10 lb (3.774 Kilogram)
Age
8+ years (18 Year)
Sex
Female Unknown
Region
USA
Reactions
KnucklingOverdose
Body systems
Other
Outcomes
Ongoing

USA-USFDACVM-2025-US-072769

Received 2025-12-08 · MSK · MSK

Serious
Species
Dog
Breed
Shih Tzu
Size / weight
10-24 lb (6.35 Kilogram)
Age
8+ years (14 Year)
Sex
Female Unknown
Region
USA
Reactions
MalaiseNot himself/herselfConfusionSleepiness - systemic disorderArched backFallingCollapse NOS (see also Cardio-vascular and Neurological disorders)Intervertebral disc diseaseHead downParalysisVocalisationNot defecatingPain NOSHead shake - behavioural disorderRotatory nystagmusDeath by euthanasia
Body systems
OtherNeurologicBehavior
Outcomes
Euthanized

USA-USFDACVM-2025-US-072925

Received 2025-12-05 · MSK · MSK

Serious
Species
Dog
Breed
['Bulldog - American', 'Dog (unknown)']
Size / weight
50-99 lb (27.941 Kilogram)
Age
8+ years (9 Year)
Sex
Male Intact
Region
USA
Reactions
UnwellRecumbencyReduced responsesSeizure NOSStrokeDeathOverdose
Body systems
OtherNeurologic
Outcomes
Died

USA-USFDACVM-2025-US-072887

Received 2025-12-05 · MSK · MSK

Non-serious
Species
Dog
Breed
Retriever - Labrador
Size / weight
50-99 lb (34.428 Kilogram)
Age
8+ years (13 Year)
Sex
Female Unknown
Region
USA
Reactions
Lethargy (see also Central nervous system depression in Neurological)Unable to standWeakness
Body systems
NeurologicOther
Outcomes
Ongoing

USA-USFDACVM-2025-US-071935

Received 2025-12-04 · MSK · MSK

Serious
Species
Dog
Breed
Retriever - Labrador
Size / weight
50-99 lb (37.1 Kilogram)
Age
8+ years (12.42 Year)
Sex
Male Neutered
Region
USA
Reactions
Dermal plaqueCrustScaleAlopecia NOSSkin lesion NOSBacterial skin infection NOS
Body systems
OtherSkin & allergy
Outcomes
Ongoing

USA-USFDACVM-2025-US-071646

Received 2025-12-04 · MSK · MSK

Serious
Species
Dog
Breed
['Collie - Border', 'Dog (unknown)']
Size / weight
25-49 lb (20.321 Kilogram)
Age
8+ years (14 Year)
Sex
Female Unknown
Region
USA
Reactions
Lethargy (see also Central nervous system depression in Neurological)GrowlingBiting -aggression (see also Skin and appendages disorders)Not himself/herselfPacingCoughEmesis (multiple)RegurgitationWeaknessAtaxiaNot eatingElevated alanine aminotransferase (ALT)Elevated serum alkaline phosphatase (ALP)Elevated renal parametersHyperphosphataemiaUnable to walk
Body systems
NeurologicOtherBehaviorDigestive
Outcomes
Ongoing

USA-USFDACVM-2025-US-072872

Received 2025-12-03 · MSK · MSK

Serious
Species
Dog
Breed
Shih Tzu
Size / weight
10-24 lb (7.076 Kilogram)
Age
8+ years (14.83 Year)
Sex
Male Neutered
Region
USA
Reactions
Renal failureWeight lossSeizure NOSVocalisationAnaemia NOSHypertensionHepatomegalyCircling - neurological disorder (see also Behavioural disorders)UrolithiasisDeath by euthanasiaHyperkalaemiaShakingElevated blood urea nitrogen (BUN)Elevated alanine aminotransferase (ALT)Elevated serum alkaline phosphatase (ALP)Abnormal radiograph findingElevated symmetrical dimethylarginine (SDMA)
Body systems
OtherNeurologic
Outcomes
Euthanized

USA-USFDACVM-2025-US-071572

Received 2025-12-03 · MSK · MSK

Serious
Species
Dog
Breed
Retriever - Golden
Size / weight
50-99 lb (3 Kilogram)
Age
8+ years (9.5 Year)
Sex
Male Neutered
Region
USA
Reactions
Claw / hoof / nail disorder NOSMuscle atrophy (see also Muscle wasting)Hip dysplasiaBone and joint disorder NOSLack of efficacy - NOSWalking slowlyHind limb paresisDiscomfort NOSTense musclesMusculoskeletal disorder NOSCartilage degeneration
Body systems
OtherEffectiveness
Outcomes
Ongoing

USA-USFDACVM-2025-US-071565

Received 2025-12-03 · MSK · MSK

Serious
Species
Dog
Breed
Dog (unknown)
Size / weight
25-49 lb (14.969 Kilogram)
Age
8+ years (15 Year)
Sex
Male Neutered
Region
USA
Reactions
Head tilt - neurological disorder (see also Head tilt - ear disorder)Walking difficultyVomitingSkin and tissue infection NOSGeneral illnessDeath
Body systems
NeurologicOtherDigestive
Outcomes
Died

USA-USFDACVM-2025-US-071867

Received 2025-12-02 · MSK · MSK

Non-serious
Species
Cat
Breed
Maine Coon
Size / weight
10-24 lb (7.257 Kilogram)
Age
1-3 years (2 Year)
Sex
Male Neutered
Region
USA
Reactions
Prescribing errorVomitingDiarrhoeaLethargy (see also Central nervous system depression in Neurological)
Body systems
OtherDigestiveNeurologic
Outcomes
Recovered/Normal

USA-USFDACVM-2025-US-073471

Received 2025-12-01 · MSK · MSK

Serious
Species
Dog
Breed
Sheepdog (unspecified)
Size / weight
100+ lb (51.71 Kilogram)
Age
8+ years (1 Year)
Sex
Male Intact
Region
USA
Reactions
WobblinessUnable to walkSpinal pain NOSHemiparesis (weakness L or R side)Impaired proprioceptionDeath by euthanasiaUrinary incontinence
Body systems
Other
Outcomes
Euthanized

USA-USFDACVM-2025-US-072463

Received 2025-12-01 · MSK · MSK

Non-serious
Species
Dog
Breed
['Rottweiler', 'Retriever - Labrador']
Size / weight
50-99 lb (27.76 Kilogram)
Age
8+ years (14 Year)
Sex
Male Neutered
Region
USA
Reactions
Proprioception deficitMusculoskeletal disorder NOSLethargy (see also Central nervous system depression in Neurological)AnorexiaReluctant to moveBradycardiaArrhythmiaPyrexiaLymphocytosisLeucocytosis NOSLow thyroxine (T4)Elevated symmetrical dimethylarginine (SDMA)Urinary tract infection
Body systems
OtherNeurologicDigestive
Outcomes
Ongoing

USA-USFDACVM-2025-US-072174

Received 2025-12-01 · MSK · MSK

Non-serious
Species
Dog
Breed
Terrier - Yorkshire
Size / weight
10-24 lb (6.12 Kilogram)
Age
8+ years (13 Year)
Sex
Female Neutered
Region
USA
Reactions
Partial lack of efficacyAlopeciaErythema (for urticaria see Immune SOC)PapuleExcoriationSkin scabBacterial skin infection NOSAbnormal cytology
Body systems
EffectivenessSkin & allergyOther
Outcomes
Ongoing

Tap or hover a reaction to see what it means in plain language.

Tracked signals
32
Reported cases
32
Serious reports
23
Species represented
2
Grouped by Body System
Digestive (2) · Loss of appetite, Blood in vomit Skin & allergy (2) · Hair loss, Alopecia NOS Neurologic (2) · Unsteady walking (ataxia), Circling - neurological disorder Behavior (3) · Biting -aggression, Behavioral disorder (unspecified), Anxiety Other (23) · Chewing disorder, Cartilage degeneration, Bumping into walls
Most Reported Reactions
Reaction Body system Cases Species Serious cases
Neurologic 1 Dog 1
Digestive 1 Dog 1
Neurologic 1 Dog 1
Other 1 Dog 1
Other 1 Dog 1
Other 1 Dog 1
Other 1 Dog 1
Digestive 1 Dog 1

Species coverage: Dog (30) Cat (2)

View detailed reaction table
Reaction Body system Species Seriousness Frequency Reports
Neurologic Dog Serious - 1
Digestive Dog Serious - 1
Skin & allergy Dog Non-serious - 1
Neurologic Dog Serious - 1
Other Dog Serious - 1
Other Dog Serious - 1
Other Dog Serious - 1
Other Dog Non-serious - 1
Other Dog Serious - 1
Other Dog Non-serious - 1
Digestive Dog Serious - 1
Other Dog Non-serious - 1
Behavior Dog Serious - 1
Behavior Dog Serious - 1
Other Dog Serious - 1
Other Dog Serious - 1
Other Dog Serious - 1
Other Dog Non-serious - 1
Other Dog Non-serious - 1
Other Dog Serious - 1
Behavior Dog Serious - 1
Other Dog Serious - 1
Skin & allergy Dog Serious - 1
Other Dog Serious - 1
Other Dog Serious - 1
Other Cat Non-serious - 1
Other Dog Serious - 1
Other Dog Serious - 1
Other Dog Serious - 1
Other Dog Serious - 1
Other Dog Non-serious - 1
Other Cat Non-serious - 1
Source metadata:

Source Documents

The most useful source links appear first; full previews and metadata stay in the veterinary/professional layer.

Use original documents to confirm product-specific warnings, ingredients, and handling details with your veterinarian.

N-141562-C-0024-NL-AA_PI.pdf Official label / PI · Labeling Librela™ SPL · SPL Librela SPL SPL · Structured Product Label

Full source previews and metadata remain in the veterinary/professional layer.

Owner handouts

0
No owner handouts linked yet.

Official label / PI

1

SPL

2

FOI

1

N-141562-C-0024-NL-AA_PI.pdf

Official label / PI · Labeling

Open original

Librela™

SPL · SPL

Open original
FDA Structured Product Label

Librela™

Rendered from Roxee's cached FDA SPL package contents for on-page reading. Use Open original for the raw FDA ZIP/XML source.

Sponsor
Zoetis Inc.
NADA
141-562
Status
RX
Form
Injectable Solution
Route
Subcutaneous
Species
Dog
Composition / specifications
5, 10, 15, 20, and 30 mg bedinvetmab/mL in sterile solution

Dogs

Indication

For the control of pain associated with osteoarthritis in dogs.

Dosage

Administer 0.23 mg/pound (0.5 mg/kilogram) body weight monthly by subcutaneous injection.

Librela SPL

SPL · Structured Product Label

Open original
FDA Structured Product Label XML for Librela. Use the source link for the full official labeling record.

FOI Summary oN 141-562 Approved May 5, 2023.pdf

FOI · FOI

Open original
Source metadata:
Veterinary reference (advanced)

Canonical medication sections are above. This legacy block remains available for deeper cross-reference without cluttering the primary workflow.

At a Glance

Quick facts and links to official labeling and safety signals.

Data freshness
  • Reference facts: Source Roxee | Refreshed Jun 22, 2026, 10:41 AM UTC
    The reference fact projection used for browse cards and quick facts.
  • Animal Drugs @ FDA: Source FDA | Refreshed Jun 22, 2026, 10:40 AM UTC
    Applications/products are imported from FDA export data.
  • Animal Drugs @ FDA previews: Source FDA | Refreshed Feb 9, 2026, 3:05 AM UTC
    Label highlights/doc links are fetched from FDA preview endpoints.
  • Animal Drug Product Listing Directory (NDC): Source FDA | Refreshed Jun 22, 2026, 10:41 AM UTC
    Package/product NDCs from FDA’s electronic listing directory (XLS).
  • openFDA reaction terms: Source FDA openFDA | Refreshed Jun 22, 2026, 10:45 AM UTC
  • openFDA case summaries: Source FDA openFDA | Refreshed Jun 22, 2026, 10:45 AM UTC
Official (FDA)
Identity: Generic ingredient • FDA branded products available
Official FDA brands: Librela
Manufacturer mapping: Zoetis Inc.
Case-reported brands (openFDA): MSK
Catalog species: Both • FDA-labeled species: Dog
Rx/OTC: RX
Form/route: Injectable Solution • Subcutaneous
Applications: NADA 141-562
NDC: Packages 54771-2772-1 54771-2772-2 54771-2778-1 54771-2778-2 54771-2779-1 54771-2779-2 • Products 54771
Documents: 2 (FOI: 1) • SPL: 1 • Label highlights • Official documents
Safety (openFDA)
Top reactions: Dog 251 • Cat 4 • View
Case summaries: 76 (showing 8) • View
openFDA reports are unverified and do not prove causation.
Explore
Linked using: Fda_Label (0.95), Fda_Label (0.95), Fda_Label (0.95)
Diagnosis Codes
ICD10_CM: M19.90
Unspecified osteoarthritis, unspecified site

Counseling and Monitoring Highlights

Global Pet owner/Vet mode is controlled in the header. This section avoids duplicate in-page persona tabs.

Top reaction signals
Unsteady walking (ataxia) (1) Loss of appetite (1) Circling - neurological disorder (1) Chewing disorder (1) Cartilage degeneration (1) Bumping into walls (1) Bone and joint disorder NOS (1) Blood in vomit (1)

Identifiers & Packages

Normalized identifiers (NDC/NADA/ANADA) and package metadata from regulator listings.

Identifiers
NADA: 141562 NDC Package: 54771-2772-1 NDC Package: 54771-2772-2 NDC Package: 54771-2778-1 NDC Package: 54771-2778-2 NDC Package: 54771-2779-1 NDC Package: 54771-2779-2 NDC Package: 54771-2780-1 NDC Package: 54771-2780-2 NDC Package: 54771-2781-1 NDC Package: 54771-2781-2 NDC Product: 54771
Package NDC Product NDC Form / Route Status
54771-2772-1 54771 -
54771-2772-2 54771 -
54771-2778-1 54771 -
54771-2778-2 54771 -
54771-2779-1 54771 -
54771-2779-2 54771 -
54771-2780-1 54771 -
54771-2780-2 54771 -
54771-2781-1 54771 -
54771-2781-2 54771 -

Enriched Documents

Documents are tiered by source trust: Official, Clinical, Manufacturer, Marketing.

Data Sources & Change Log

Every non-trivial field is expected to include provenance and update timestamps.

Official 122 Clinical 1 Manufacturer 0 Marketing 0
Current Field Facts
  • side_effects: Top reported reactions (openFDA): Death by euthanasia, Lethargy (see also Central nervous system depression in Neurological), Polydipsia, Ataxia, Vomiting, Pol… (Clinical, 2026-04-11)
  • dosage_forms: Injection (Official, 2026-06-22)
  • dosage_forms: Injection (Official, 2026-06-22)
  • dosage_forms: Injection (Official, 2026-06-21)
  • dosage_forms: Injection (Official, 2026-06-20)
  • dosage_forms: Injection (Official, 2026-06-13)
  • dosage_forms: Injection (Official, 2026-06-12)
  • dosage_forms: Injection (Official, 2026-06-12)
  • dosage_forms: Injection (Official, 2026-06-11)
  • dosage_forms: Injection (Official, 2026-06-11)
  • dosage_forms: Injection (Official, 2026-06-10)
  • dosage_forms: Injection (Official, 2026-06-09)
  • dosage_forms: Injection (Official, 2026-06-08)
  • dosage_forms: Injection (Official, 2026-06-07)
  • dosage_forms: Injection (Official, 2026-06-06)
  • dosage_forms: Injection (Official, 2026-06-05)
  • dosage_forms: Injection (Official, 2026-06-04)
  • dosage_forms: Injection (Official, 2026-06-03)
  • dosage_forms: Injection (Official, 2026-06-02)
  • dosage_forms: Injection (Official, 2026-06-01)
Recent Revisions
  • side_effects updated 2026-04-12 10:05 by etl_backfill • Backfilled from existing medication fields
  • usage updated 2026-04-12 10:05 by etl_backfill • Backfilled from existing medication fields
  • side_effects updated 2026-04-11 10:05 by etl_backfill • Backfilled from existing medication fields
  • usage updated 2026-04-11 10:05 by etl_backfill • Backfilled from existing medication fields
  • side_effects updated 2026-02-12 22:44 by etl_backfill • Backfilled from existing medication fields
  • usage updated 2026-02-12 22:44 by etl_backfill • Backfilled from existing medication fields

FDA Products & Applications (Animal Drugs @ FDA)

Official sponsor/proprietary-name/application-status records linked by active ingredient.

Product Sponsor Application Status Published
Librela™
RX
Bedinvetmab
Injectable Solution • Subcutaneous
Label highlights
Official documents
Zoetis Inc. NADA 141-562 Approved Feb 19, 2025

Data source: FDA Animal Drugs @ FDA (public search export).

What It's For (FDA Label Highlights)

Extracted from FDA Animal Drugs @ FDA product labeling. Always confirm details with your veterinarian.

Species: Dog
Composition / specifications
5, 10, 15, 20, and 30 mg bedinvetmab/mL in sterile solution
Dogs
Indication

For the control of pain associated with osteoarthritis in dogs.

Dosage

Administer 0.23 mg/pound (0.5 mg/kilogram) body weight monthly by subcutaneous injection.

Limitations

FDA page: Open in Animal Drugs @ FDA

Usage

For the control of pain associated with osteoarthritis in dogs.

Source: FDA Animal Drugs @ FDA • Reference

Top Reported Reactions (openFDA)

De-duplicated reaction terms grouped by body system from FDA openFDA reports (not verified; does not prove causation).

Digestive
Loss of appetite (1) • Dog Blood in vomit (1) • Dog

Showing top 5 for Digestive.

Skin & allergy
Hair loss (1) • Dog Alopecia NOS (1) • Dog

Showing top 5 for Skin & allergy.

Neurologic
Unsteady walking (1) • Dog Circling - neurological disorder (1) • Dog

Showing top 5 for Neurologic.

Behavior
Biting -aggression (1) • Dog Behavioral disorder (1) • Dog Anxiety (1) • Dog

Showing top 5 for Behavior.

Other
Chewing disorder (1) • Dog Cartilage degeneration (1) • Dog Bumping into walls (1) • Dog Bradycardia (1) • Dog Bone and joint disorder NOS (1) • Dog
Show more (18)
Blood loss NOS (1) • Dog Blood in urine (1) • Dog Barking (1) • Dog Bacterial skin infection NOS (1) • Dog Aspiration pneumonia (1) • Dog Arthritis (1) • Dog Arrhythmia (1) • Dog Arched back (1) • Dog Anaemia NOS (1) • Dog Agitation (1) • Dog Agglutination test, positive (1) • Dog Accidental exposure (1) • Cat Abnormal tail posture (1) • Dog Abnormal radiograph finding (1) • Dog Abnormal posture NOS (1) • Dog Abnormal cytology (1) • Dog Abnormal adrenocorticotropic hormone (ACTH) stimulation test (1) • Dog Abdominal discomfort (1) • Cat

Showing top 5 for Other.

Data source: FDA openFDA Animal & Veterinary adverse event reports.

Adverse Event Case Summaries (openFDA)

These are individual FDA adverse event reports. They are unverified and do not prove the medication caused the reaction.

Dog, Shepherd Dog - German, Female, 11 year, 20.865 kilogram • Drug: MSK, Solution, Subcutaneous, Dose: 15 Milligram per animal • Reactions: Vomiting, Not eating, Tiredness (lethargy), Reluctant to move, Seizure NOS • Outcome: Ongoing

  • Report ID: USA-USFDACVM-2025-US-075421
  • Serious AE: Yes
  • Treated For AE: No
  • Sex: Female
  • Age: 11.00 Year
  • Weight: 20.865 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Subcutaneous
  • Form: Solution
  • Dose: 15 Milligram per animal
Reactions Reported:
Vomiting Not eating Tiredness (lethargy) Reluctant to move Seizure NOS
Outcomes: Ongoing

Dog, Corgi (unspecified), Male, 11 year, 12.156 kilogram • Drug: MSK, Solution, Subcutaneous, Dose: 1 dose per animal • Reactions: Proprioception deficit, Lumbar pain, Falling, Difficulty to rise, Decreased activity… • Outcome: Ongoing

  • Report ID: USA-USFDACVM-2025-US-075346
  • Serious AE: No
  • Treated For AE: No
  • Sex: Male
  • Age: 11.00 Year
  • Weight: 12.156 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Subcutaneous
  • Form: Solution
  • Dose: 1 dose per animal
Reactions Reported:
Proprioception deficit Lumbar pain Falling Difficulty to rise Decreased activity General illness
Outcomes: Ongoing

Dog, Shepherd Dog - Australian, Female, 12 year, 23.133 kilogram • Drug: MSK, Solution, Subcutaneous, Dose: 15 Milligram per animal • Reactions: Trembling, Unsteady walking (ataxia), Panting, Urinary incontinence • Outcome: Recovered/Normal

  • Report ID: USA-USFDACVM-2025-US-075198
  • Serious AE: No
  • Treated For AE: No
  • Sex: Female
  • Age: 12.00 Year
  • Weight: 23.133 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Subcutaneous
  • Form: Solution
  • Dose: 15 Milligram per animal
Reactions Reported:
Trembling Unsteady walking (ataxia) Panting Urinary incontinence
Outcomes: Recovered/Normal

Dog, Chihuahua, Male, 12 year, 3.084 kilogram • Drug: MSK, Solution, Subcutaneous, Dose: 0.30 mL per animal • Reactions: Seizure NOS, Lateral recumbency, Unresponsive to stimuli, Bradycardia • Outcome: Recovered/Normal

  • Report ID: USA-USFDACVM-2025-US-075262
  • Serious AE: Yes
  • Treated For AE: Yes
  • Sex: Male
  • Age: 12.00 Year
  • Weight: 3.084 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Subcutaneous
  • Form: Solution
  • Dose: 0.30 mL per animal
Reactions Reported:
Seizure NOS Lateral recumbency Unresponsive to stimuli Bradycardia
Outcomes: Recovered/Normal

Dog, Dog (unknown), Female • Drug: MSK, Solution, Unknown • Reactions: Unable to walk • Outcome: Outcome Unknown

  • Report ID: USA-USFDACVM-2025-US-075344
  • Serious AE: No
  • Treated For AE: No
  • Sex: Female
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Unknown
  • Form: Solution
Reactions Reported:
Unable to walk
Outcomes: Outcome Unknown

Dog, ['Retriever (unspecified)', 'Dog (unknown)'], Male, 12 year, 30.754 kilogram • Drug: MSK, Solution, Subcutaneous, Dose: 20 Milligram per animal • Reactions: Not eating, Wobbliness, Tiredness (lethargy) • Outcome: Ongoing

  • Report ID: USA-USFDACVM-2025-US-075395
  • Serious AE: Yes
  • Treated For AE: Yes
  • Sex: Male
  • Age: 12.00 Year
  • Weight: 30.754 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Subcutaneous
  • Form: Solution
  • Dose: 20 Milligram per animal
Reactions Reported:
Not eating Wobbliness Tiredness (lethargy)
Outcomes: Ongoing

Dog, Retriever - Labrador, Male, 14 year, 37.467 kilogram • Drug: MSK, Solution, Subcutaneous, Dose: 20 Milligram per animal • Reactions: Tiredness (lethargy), Urinary incontinence, Unable to stand, Faecal incontinence, Not eating… • Outcome: Died

  • Report ID: USA-USFDACVM-2025-US-075264
  • Serious AE: Yes
  • Treated For AE: No
  • Sex: Male
  • Age: 14.00 Year
  • Weight: 37.467 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Subcutaneous
  • Form: Solution
  • Dose: 20 Milligram per animal
Reactions Reported:
Tiredness (lethargy) Urinary incontinence Unable to stand Faecal incontinence Not eating Not drinking Difficulty going up/down stairs Limb weakness Bumping into walls Recumbency Death
Outcomes: Died

Dog, Weimaraner, Male, 9 year, 58.513 kilogram • Drug: MSK, Solution, Subcutaneous, Dose: 30 Milligram per animal • Reactions: Lack of efficacy - NOS, Musculoskeletal disorder NOS • Outcome: Ongoing

  • Report ID: USA-USFDACVM-2025-US-075205
  • Serious AE: Yes
  • Treated For AE: Yes
  • Sex: Male
  • Age: 9.00 Year
  • Weight: 58.513 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Subcutaneous
  • Form: Solution
  • Dose: 30 Milligram per animal
Reactions Reported:
Lack of efficacy - NOS Musculoskeletal disorder NOS
Outcomes: Ongoing

Data source: FDA openFDA Animal & Veterinary adverse event reports.

Overdose Information

No approved overdose-management text is linked yet. If overdose is suspected, contact a veterinarian or emergency clinic immediately.

Storage & Handling

No approved storage guidance is linked yet for this ingredient. Use manufacturer packaging and veterinary guidance for handling/storage.

Share Your Thoughts

Let others know your experience or advice regarding this medication.

This medication has not been reviewed by a veterinarian yet.