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Roxee Medication Guide

Gabapentin

Medication reference facts with explicit FDA-approval, off-label, source-limited, and safety context. Roxee does not sell, prescribe, or dispense medications.

Both Reference partial Not FDA-approved for animals Multiple FDA labelers Official label facts Owner quick guide first
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Data freshness

Reference facts
Reference refreshed
Aug 6, 2026, 7:47 p.m.

Roxee has a partial reference profile for this medication. Some primary facts still need verification.

FDA applications
FDA application data refreshed
Aug 6, 2026, 7:47 p.m.

Sponsor, product, and application records imported from Animal Drugs @ FDA.

Safety reports
Safety data refreshed
Aug 6, 2026, 7:49 p.m.

openFDA reaction terms and case summaries are supporting evidence, not proof of causality.

Source timing details
Source timing details
  • Reference facts: Source Roxee | Refreshed Aug 6, 2026, 7:47 PM UTC
    The reference fact projection used for browse cards and quick facts.
  • Animal Drug Product Listing Directory (NDC): Source FDA | Refreshed Aug 6, 2026, 7:47 PM UTC
    Package/product NDCs from FDA’s electronic listing directory (XLS).
  • openFDA reaction terms: Source FDA openFDA | Refreshed Aug 6, 2026, 7:52 PM UTC
  • openFDA case summaries: Source FDA openFDA | Refreshed Aug 6, 2026, 7:52 PM UTC
Illustration placeholder
Gabapentin

Gabapentin

Drug type: Generic ingredient • Branded profile • Not FDA-approved for animals

Both 86% reference complete

Species: Both

Approval status: Not FDA-approved as an animal drug. No FDA-approved animal-drug application is linked for this record. It may represent extra-label, human-drug, bulk-compounding, export-only, or otherwise unapproved animal-use source data; use only under veterinarian direction.

Medication Snapshot

Merged from the current Roxee medication system with field-level provenance, freshness, and completeness tracking.

Gabapentin

Used for neuropathic pain and as an adjunct for seizure control; also used for situational anxiety/sedation in some cases. Species commonly shown: Both.

Generic name
Gabapentin
Brand names
GABAPENTIN, SolutitionKits
Manufacturer
Multiple FDA labelers
Species
Both
Completeness
86%
Validation
Incomplete
Brand names
GABAPENTIN SolutitionKits

Indications / Uses

Used for neuropathic pain and as an adjunct for seizure control; also used for situational anxiety/sedation in some cases.

Administration / How To Give

Oral

Storage

Store at room temperature.

Warnings / Contraindications

Use caution with kidney disease; dose adjustments may be needed.

  • Use caution with kidney disease; dose adjustments may be needed.

Side Effects

Sedation, ataxia, mild GI upset.

FAQ

Both

Store at room temperature.

Related Medications

Bedinvetmab Same category: Pain & Arthritis Carprofen Same category: Pain & Arthritis Deracoxib Same category: Pain & Arthritis Grapiprant Same category: Pain & Arthritis Meloxicam Same category: Pain & Arthritis Robenacoxib Same category: Pain & Arthritis

Related Conditions

Pain (acute, chronic)

Source Transparency

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Pet Owner Quick Guide

Start here first for the safest next-step summary before the deeper medication detail.

Used for:

Used for neuropathic pain and as an adjunct for seizure control; also used for situational anxiety/sedation in some cases.

Dosing note:

Exact dosing depends on your pet's species, weight, and health status. Use your veterinarian's instructions for the exact dose and schedule.

What to watch for:

  • Use caution with kidney disease
  • dose adjustments may be needed
  • Thrombocytopenia (4 reports)
  • Elevated symmetrical dimethylarginine (4 reports)
  • Conjunctivitis (3 reports)

When to call the vet:

  • Repeated vomiting or diarrhea.
  • Severe lethargy (hard to wake, very low energy).
  • Collapse or fainting.
  • Trouble breathing.
  • Facial swelling or hives.
  • Blood in vomit or stool.

What to tell or ask your vet today:

  • Is this medicine the right fit for my pet’s current symptoms?
  • Which warning signs mean I should call back right away?
  • How should I handle missed doses or refusal to take the medicine?

Next actions

Talk to a Vet / Find a Vet Near You Save to pet meds Share page Review report evidence
Research brief

Medication Research Insights

A source-aware map of what to know, what is uncertain, and what to verify with your veterinarian.

Source Backed Signals

What to know

Evidence-backed context Limited

Roxee has limited cited overview evidence for Gabapentin; use the official documents and your veterinarian's instructions for product-specific decisions.

Source: openFDA reaction aggregate term
Safety signal coverage Reported signals

32 tracked reaction signals; 60 reported cases; 7 serious reports; 2 species groups. These are reporting and label-derived signals for interpretation with a veterinarian.

Source: openFDA reaction aggregate term
Interpretation guardrail Not causation

Adverse-event reports help form a watch list, but they do not prove the medication caused the reaction and they are not a risk ranking between medications.

Evidence tension

Stronger signal Label / review

Official labels, package inserts, and reviewed summaries carry more weight than isolated reports.

Source: openFDA reaction aggregate term
Weaker signal Reported data

Case reports and openFDA terms are useful for pattern awareness, but they are incomplete, can include multiple exposures, and do not estimate an individual pet's probability of harm.

Reaction signal map

Most reported reactions Top terms

Thrombocytopenia (4 reports), Elevated symmetrical dimethylarginine (4 reports), Conjunctivitis (3 reports), Urolithiasis (2 reports), Unclassifiable adverse event (2 reports)

Body systems represented Signal grouping

Effectiveness (1), Other (31)

Explore supporting adverse reports

Species and breed lens

Species represented in reports Species lens

Dog (48 reports), Cat (12 reports)

Breed metadata in reports Metadata only

Domestic Shorthair (2), Retriever - Labrador (2), Schnauzer - Miniature (1), Crossbred Canine/dog (1). These are report metadata, not proof that a breed is at higher risk.

What your vet may verify

Fit for this patient Vet check

Verify whether Gabapentin fits the pet's species, current diagnosis, age, weight, organ status, pregnancy/lactation status, and concurrent medications.

Evidence limitations Evidence review

Separate label-backed warnings from adverse-event reports and owner observations before changing the plan.

What to watch next

Watch list Owner-safe

Use caution with kidney disease, dose adjustments may be needed, Thrombocytopenia, Elevated symmetrical dimethylarginine, Conjunctivitis

Call sooner if Escalation

Repeated vomiting or diarrhea. Severe lethargy (hard to wake, very low energy). Collapse or fainting.

Bottom line: Use this Gabapentin brief as a structured watch list and source map, not as a reason to start, stop, or change treatment without your veterinarian.
Vet source depth
  1. openFDA reaction aggregate term · adverse_reaction · adverse reactions
  2. Medication contraindications · safety_warning · warnings contraindications
  3. Structured Product Label · document · documents
  4. Structured Product Label · document · documents
  5. Structured Product Label · document · documents
  6. Structured Product Label · document · documents

Evidence

Review status / Updated / Sources

Review status: Clinical reviewer not listed

Updated: April 15, 2026, 10:04 AM UTC

Sources:
Safety & side effects

Side effects to monitor:

  • Use caution with kidney disease
  • dose adjustments may be needed
  • Thrombocytopenia
  • Elevated symmetrical dimethylarginine
  • Conjunctivitis

Most reported reactions:

  • Thrombocytopenia (4 reports)
  • Elevated symmetrical dimethylarginine (4 reports)
  • Conjunctivitis (3 reports)
Explore reported case details

Emergency warning signs:

  • Repeated vomiting or diarrhea.
  • Severe lethargy (hard to wake, very low energy).
  • Collapse or fainting.
  • Trouble breathing.
Talk to a Vet / Find a Vet Near You Start Symptom Intake

Vet Fast Scan

Source-backed clinical checkpoints for quick review.

FDA-labeled species
Not linked yet
Indication / use
Used for neuropathic pain and as an adjunct for seizure control; also used for situational anxiety/sedation in some cases.
Form / route / dose
Confirm product label and patient-specific plan.
Warnings
  • High: Use caution with kidney disease; dose adjustments may be needed.
Adverse-event caveat
openFDA adverse-event cases are reported signals. They are not verified, do not prove causation, and do not estimate a pet's individual risk.
Source docs

Quick Facts

Official label facts first, then secondary summaries. Marketing content is separated below.

Species: Both
Manufacturer: Multiple FDA labelers
Identifiers:
NDC Package: 46144-600-01 NDC Package: 62157-711-01 NDC Package: 73377-176-01 NDC Package: 86032-041-01 NDC Product: 46144 NDC Product: 62157 NDC Product: 73377 NDC Product: 86032

Warnings / Contraindications

Use caution with kidney disease; dose adjustments may be needed.

  • High: Use caution with kidney disease; dose adjustments may be needed.
Source metadata:

Adverse Reactions

Snapshot first, detailed rows second. This section summarizes signal data and is not a diagnosis.

Reported case explorer

Filter stored openFDA reports by pet and report attributes. Counts describe reports in this data set, not risk.

Clear filters
openFDA adverse-event cases are reported signals. They are not verified, do not prove causation, and do not estimate a pet's individual risk.
Stored reports
164
Matching reports
50
Active filters
1
Selected filters
Body system: Digestive Clear
Reset
Drill into common report signals
Lethargy (see also Central nervous system depression in Neurological) (35) Abnormal radiograph finding (22) Death by euthanasia (18) Intentional misuse (18) Other (152) Neurologic (62) Digestive (50) Skin & allergy (27)
Showing up to 50 matching reports.

USA-USFDACVM-2026-US-014374

Received 2026-03-25 · MSK · MSK

Serious
Species
Dog
Breed
Crossbred Canine/dog
Size / weight
50-99 lb (32.205 Kilogram)
Age
8+ years (1 Year)
Sex
Male Neutered
Region
USA
Reactions
Musculoskeletal disorder NOSAggressionUnable to walkUrinary incontinenceMelaenaEmesis (multiple)Lethargy (see also Central nervous system depression in Neurological)Death by euthanasiaNeurological signs NOS
Body systems
OtherBehaviorDigestiveNeurologic
Outcomes
Euthanized

USA-USFDACVM-2026-US-014048

Received 2026-03-24 · MSK · MSK

Serious
Species
Dog
Breed
Shepherd Dog - German
Size / weight
50-99 lb (35.698 Kilogram)
Age
8+ years (9 Year)
Sex
Female Unknown
Region
USA
Reactions
Joint painLamenessDepressionDifficulty standingDecreased appetiteAbnormal radiograph findingBone and joint disorder NOSJoint effusionSpondylosis
Body systems
OtherNeurologicDigestive
Outcomes
Outcome Unknown

USA-USFDACVM-2026-US-013633

Received 2026-03-19 · MSK · MSK

Non-serious
Species
Cat
Breed
Domestic Shorthair
Size / weight
10-24 lb (5.33 Kilogram)
Age
8+ years (11 Year)
Sex
Female Neutered
Region
USA
Reactions
DysphoriaBehavioural disorder NOSDilated pupilsAnorexiaSkin and tissue infection NOSLethargy (see also Central nervous system depression in Neurological)
Body systems
OtherBehaviorDigestiveNeurologic
Outcomes
Recovered/Normal

USA-USFDACVM-2026-US-013262

Received 2026-03-19 · MSK · MSK

Serious
Species
Cat
Breed
Persian
Size / weight
Under 10 lb (4.08 Kilogram)
Age
4-7 years (4 Year)
Sex
Male Neutered
Region
USA
Reactions
Laboured breathingAnorexia
Body systems
OtherDigestive
Outcomes
Recovered/Normal

USA-USFDACVM-2026-US-012895

Received 2026-03-19 · MSK · MSK

Serious
Species
Dog
Breed
Shepherd Dog - German
Size / weight
50-99 lb (30.844 Kilogram)
Age
4-7 years (4 Year)
Sex
Female Unknown
Region
USA
Reactions
Injection site painInjection site swellingEmesis (multiple)Decreased appetitePica NOSLocalised pain NOS (see other SOCs for specific pain)Eosinophilia
Body systems
OtherSkin & allergyDigestive
Outcomes
Ongoing

USA-USFDACVM-2026-US-012782

Received 2026-03-17 · MSK · MSK

Serious
Species
Dog
Breed
Setter - English
Size / weight
25-49 lb (21.772 Kilogram)
Age
8+ years (9 Year)
Sex
Male Neutered
Region
USA
Reactions
Dilated renal pelvisIntestinal thickeningAbnormal ultrasound findingBradycardiaPale mucous membraneDiarrhoeaWeight lossLethargy (see also Central nervous system depression in Neurological)LymphomaMedication error NOS
Body systems
OtherDigestiveNeurologic
Outcomes
Ongoing

USA-USFDACVM-2026-US-013278

Received 2026-03-16 · MSK · MSK

Serious
Species
Cat
Breed
Domestic Mediumhair
Size / weight
10-24 lb (6.8 Kilogram)
Age
8+ years (9 Year)
Sex
Male Neutered
Region
USA
Reactions
Injection site cystInjection site sarcomaInjection site lumpInjection site discharge NOSInjection site irritationLethargy (see also Central nervous system depression in Neurological)Elevated symmetrical dimethylarginine (SDMA)HypoalbuminaemiaThrombocytosisHyperkalaemiaAbnormal radiograph findingConstipationPain NOSAbnormal cytologyDecreased appetiteLicking at injection site
Body systems
OtherNeurologicDigestive
Outcomes
Ongoing

USA-USFDACVM-2026-US-013066

Received 2026-03-16 · MSK · MSK

Serious
Species
Dog
Breed
Samoyed
Size / weight
50-99 lb (24.948 Kilogram)
Age
8+ years (9 Year)
Sex
Male Neutered
Region
USA
Reactions
Lethargy (see also Central nervous system depression in Neurological)ShakingPale mucous membraneCold feeling of extremityVomitingTachycardiaLaboured breathingTachypnoeaDehydrationWeak pulseTense abdomenHypochloraemiaHyponatremiaAzotaemiaHypocalcaemiaHypoglycaemiaHyperphosphataemiaHypoproteinaemiaHypoalbuminaemiaLow alanine aminotransferase (ALT)Elevated lactateIncreased percentage reticulocytesLymphocytosisMonocytosisAbnormal red blood cellHypotensionAbdominal effusionAspiration pneumoniaHeart murmurGastric perforationLateral recumbencySepticaemiaCoagulopathyHypernatraemiaHypercalcaemiaElevated serum alkaline phosphatase (ALP)NeutrophiliaStridor (Upper respiratory; for lower respiratory see also Bronchial rale)Unresponsive to stimuliCyanotic mucous membranesThrombosisOedema of the extremities (see also other SOCs for most applicable oedema)Pitting oedemaLamenessElevated aspartate aminotransferase (AST)Stertor
Body systems
NeurologicOtherDigestive
Outcomes
Ongoing

USA-USFDACVM-2026-US-012478

Received 2026-03-16 · MSK · MSK

Serious
Species
Dog
Breed
['Retriever - Labrador', 'Terrier - Bull - American Pit']
Size / weight
50-99 lb (31.298 Kilogram)
Age
8+ years (14 Year)
Sex
Female Neutered
Region
USA
Reactions
Limb weaknessDecreased appetiteDeath by euthanasiaLethargy (see also Central nervous system depression in Neurological)Panting
Body systems
OtherDigestiveNeurologic
Outcomes
Euthanized

USA-USFDACVM-2026-US-011996

Received 2026-03-13 · MSK · MSK

Serious
Species
Dog
Breed
Terrier - Bull - American Pit
Size / weight
50-99 lb (29.937 Kilogram)
Age
4-7 years (5 Year)
Sex
Male Neutered
Region
USA
Reactions
Injection site painAnorexiaFeverInjection site swellingInjection site abscessLethargy (see also Central nervous system depression in Neurological)
Body systems
OtherDigestiveSkin & allergyNeurologic
Outcomes
Ongoing

USA-USFDACVM-2026-US-011895

Received 2026-03-11 · MSK · MSK

Serious
Species
Cat
Breed
Domestic Shorthair
Size / weight
Under 10 lb (4.377 Kilogram)
Age
1-3 years (1.5 Year)
Sex
Female Unknown
Region
USA
Reactions
VomitingLocalised pain NOS (see other SOCs for specific pain)Limb non-weight bearingLethargy (see also Central nervous system depression in Neurological)Not eatingHead tremorIncreased respiratory ratePlantigrade postureLimb weaknessProprioception deficitCutaneous emphysemaAbnormal radiograph findingKnuckling
Body systems
DigestiveOtherNeurologic
Outcomes
Ongoing

USA-USFDACVM-2026-US-011648

Received 2026-03-10 · MSK · MSK

Serious
Species
Cat
Breed
Domestic Shorthair
Size / weight
10-24 lb (5.126 Kilogram)
Age
4-7 years (5 Year)
Sex
Female Neutered
Region
USA
Reactions
Emesis (multiple)Weight lossLethargy (see also Central nervous system depression in Neurological)Blood in vomitAbnormal ultrasound findingWeaknessDecreased appetiteINEFFECTIVE, ANTIEMETICDigestive tract disorder NOS
Body systems
DigestiveOtherNeurologic
Outcomes
Ongoing

USA-USFDACVM-2026-US-008246

Received 2026-02-24 · MSK · MSK

Serious
Species
Dog
Breed
Retriever - Labrador
Size / weight
100+ lb (48.08 Kilogram)
Age
4-7 years (7.5 Year)
Sex
Male Neutered
Region
USA
Reactions
Death by euthanasiaNot himself/herselfLethargy (see also Central nervous system depression in Neurological)VomitingHaemorrhage NOSWeight lossSternoabdominal recumbencyDehydrationDiabetic ketoacidosisAcute pancreatitisAzotaemia
Body systems
OtherNeurologicDigestive
Outcomes
Euthanized

USA-USFDACVM-2026-US-014227

Received 2026-02-23 · MSK · MSK

Non-serious
Species
Dog
Breed
Retriever - Labrador
Size / weight
100+ lb (49.895 Kilogram)
Age
4-7 years (5 Year)
Sex
Male Unknown
Region
USA
Reactions
Diarrhoea
Body systems
Digestive
Outcomes
Outcome Unknown

USA-USFDACVM-2026-US-012380

Received 2026-02-18 · MSK · MSK

Non-serious
Species
Dog
Breed
Pit Bull
Size / weight
50-99 lb (36.106 Kilogram)
Age
4-7 years (7 Year)
Sex
Female Neutered
Region
USA
Reactions
VomitingDiarrhoea
Body systems
Digestive
Outcomes
Ongoing

USA-USFDACVM-2026-US-010643

Received 2026-02-12 · MSK · MSK

Non-serious
Species
Dog
Breed
Retriever - Golden
Size / weight
50-99 lb (30.844 Kilogram)
Age
4-7 years (6 Year)
Sex
Female Unknown
Region
USA
Reactions
Localised pain NOS (see other SOCs for specific pain)Limb non-weight bearingSwollen limbWhiningUncomfortablePain NOSReluctant to moveInappropriate urinationAbnormal urine odourInjection site bleedingAnorexiaInjection site itchingInjection site irritationInjection site self traumaLimpingInjection site discharge NOSSkin irritationReddening of the skinAlopecia localInjection site scratchingInjection site swellingInjection site hair loss
Body systems
OtherDigestiveSkin & allergy
Outcomes
Outcome Unknown

USA-USFDACVM-2026-US-004494

Received 2026-02-03 · MSK · MSK

Serious
Species
Cat
Breed
Domestic Mediumhair
Size / weight
10-24 lb (6.804 Kilogram)
Age
8+ years (9 Year)
Sex
Male Neutered
Region
USA
Reactions
Injection site cystInjection site sarcomaInjection site lumpInjection site discharge NOSInjection site irritationLethargy (see also Central nervous system depression in Neurological)Elevated symmetrical dimethylarginine (SDMA)HypoalbuminaemiaThrombocytosisHyperkalaemiaAbnormal radiograph findingConstipationPain NOSAbnormal cytologyDecreased appetiteLicking at injection site
Body systems
OtherNeurologicDigestive
Outcomes
Ongoing

USA-USFDACVM-2026-US-003352

Received 2026-01-27 · MSK · MSK

Serious
Species
Cat
Breed
Domestic Shorthair
Size / weight
Under 10 lb (3.992 Kilogram)
Age
8+ years (13 Year)
Sex
Female Neutered
Region
USA
Reactions
DiarrhoeaDecreased appetiteLethargy (see also Central nervous system depression in Neurological)Bloody diarrhoeaDry mucous membraneOpen mouth breathingUnresponsive to stimuliDecreased haematocritIncreased percentage reticulocytesRegenerative anaemiaIntentional misuseThrombocytopeniaHypersalivationHeart murmur
Body systems
DigestiveNeurologicOther
Outcomes
Ongoing

USA-USFDACVM-2026-US-003528

Received 2026-01-19 · MSK · MSK

Serious
Species
Cat
Breed
Domestic Shorthair
Size / weight
Under 10 lb (4 Kilogram)
Age
8+ years (13 Year)
Sex
Female Neutered
Region
USA
Reactions
Unresponsive to stimuliOpen mouth breathingAnorexiaLethargy (see also Central nervous system depression in Neurological)DiarrhoeaDry mucous membraneBloody diarrhoeaIncreased percentage reticulocytesDecreased haematocritRegenerative anaemiaThrombocytopeniaHypersalivationMurmur
Body systems
OtherDigestiveNeurologic
Outcomes
Ongoing

USA-USFDACVM-2026-US-003268

Received 2026-01-14 · MSK · MSK

Serious
Species
Dog
Breed
Dachshund (unspecified)
Size / weight
10-24 lb (5.8 Kilogram)
Age
8+ years (15 Year)
Sex
Male Neutered
Region
USA
Reactions
VomitingLethargy (see also Central nervous system depression in Neurological)RetchingDental diseaseDry mucous membraneDehydrationAnorexiaBloody diarrhoeaIncreased heart rateIncreased respiratory ratePale mucous membraneJaundiceHeart murmurTense abdomenLeukocytosis NOSNeutrophiliaLymphocytosisMonocytosisLow platelet countAzotaemiaElevated blood urea nitrogen (BUN)HyperphosphataemiaElevated alanine aminotransferase (ALT)Elevated serum alkaline phosphatase (ALP)Elevated total bilirubinElevated cholesterol (total)Blood in urineProteinuriaLiver disorder NOSPancreas disorderIntestinal thickeningUrinary tract disorder NOSNon-regenerative anaemiaHypokalaemiaNot eatingDecreased red blood cell countDecreased haematocritPolyuriaPolydipsiaAbdominal discomfortIncreased percentage reticulocytesPlatelet disorder NOSLack of efficacy - NOSGut sounds decreasedOther blood disorder NOSBilirubinuriaAbnormal ultrasound findingElevated gamma-glutamyl transferase (GGT)ThrombocytosisIleus
Body systems
DigestiveNeurologicOtherEffectiveness
Outcomes
Ongoing

USA-USFDACVM-2026-US-004182

Received 2026-01-12 · MSK · MSK

Non-serious
Species
Cat
Breed
Domestic Shorthair
Size / weight
10-24 lb (5.1 Kilogram)
Age
4-7 years (7 Year)
Sex
Male Neutered
Region
USA
Reactions
VomitingWeight gain
Body systems
DigestiveOther
Outcomes
Outcome Unknown

USA-USFDACVM-2025-US-075421

Received 2025-12-29 · MSK · MSK

Serious
Species
Dog
Breed
Shepherd Dog - German
Size / weight
25-49 lb (20.865 Kilogram)
Age
8+ years (11 Year)
Sex
Female Unknown
Region
USA
Reactions
Emesis (multiple)Not eatingLethargy (see also Central nervous system depression in Neurological)Reluctant to moveSeizure NOS
Body systems
DigestiveOtherNeurologic
Outcomes
Ongoing

USA-USFDACVM-2025-US-075413

Received 2025-12-19 · MSK · MSK

Serious
Species
Dog
Breed
Crossbred Canine/dog
Size / weight
50-99 lb (30.119 Kilogram)
Age
8+ years (12 Year)
Sex
Male Neutered
Region
USA
Reactions
Not eatingVomitingLymphadenopathyHalitosisLow platelet countElevated alanine aminotransferase (ALT)Elevated serum alkaline phosphatase (ALP)Anxiety
Body systems
OtherDigestiveBehavior
Outcomes
Ongoing

USA-USFDACVM-2025-US-074895

Received 2025-12-19 · MSK · MSK

Serious
Species
Dog
Breed
Bloodhound
Size / weight
50-99 lb (41.28 Kilogram)
Age
4-7 years (5 Year)
Sex
Female Neutered
Region
USA
Reactions
Lethargy (see also Central nervous system depression in Neurological)Stiffness NOSWalking difficultyGeneralised weaknessNeutropeniaLow platelet countPain NOSDecreased appetiteVomitingElevated liver enzymes NOSFluid in abdomen NOSLiver disorder NOSOther immune system disorder NOSFeverLeucopenia NOSDistension of abdomenHypoglycaemiaAnaemia NOSIndigestion
Body systems
NeurologicOtherDigestive
Outcomes
Ongoing

USA-USFDACVM-2025-US-073901

Received 2025-12-19 · MSK · MSK

Serious
Species
Dog
Breed
Terrier - Bull - American Pit
Size / weight
50-99 lb (37 Kilogram)
Age
4-7 years (7 Year)
Sex
Male Neutered
Region
USA
Reactions
Loose stoolEmesis (multiple)Decreased appetiteDecreased drinkingMedication error NOSLack of efficacy - NOS
Body systems
OtherDigestiveEffectiveness
Outcomes
Ongoing

USA-USFDACVM-2025-US-074164

Received 2025-12-16 · MSK · MSK

Serious
Species
Cat
Breed
Cat (unknown)
Size / weight
Under 10 lb (3.63 Kilogram)
Age
8+ years (18 Year)
Sex
Female Neutered
Region
USA
Reactions
UnwellCryingDeath by euthanasiaDehydrationPale mucous membraneAnorexiaNot drinking
Body systems
OtherDigestive
Outcomes
Euthanized

USA-USFDACVM-2025-US-074255

Received 2025-12-15 · MSK · MSK

Non-serious
Species
Dog
Breed
Terrier - Jack Russell
Size / weight
10-24 lb (6.214 Kilogram)
Age
8+ years (13 Year)
Sex
Female Unknown
Region
USA
Reactions
Inappropriate elimination NOSProprioception deficitWeight lossVomitingDiarrhoeaProteinuriaElevated globulinsNeutrophiliaAbnormal radiograph finding
Body systems
OtherDigestive
Outcomes
Ongoing

USA-USFDACVM-2025-US-072787

Received 2025-12-15 · MSK · MSK

Serious
Species
Dog
Breed
Poodle - Standard
Size / weight
25-49 lb (20.412 Kilogram)
Age
1-3 years (2 Year)
Sex
Female Intact
Region
USA
Reactions
Death by euthanasiaConjunctivitisUlceration NOSEar canal erythemaWeltBumps on skinSkin inflammation NOSAnorexiaPain NOSDifficulty to risePyodermaAbnormal histology NOSSeizure NOSNeutropeniaMonocytosisElevated creatinineThrombocytopeniaHyperkeratosisPruritus
Body systems
OtherDigestiveNeurologicSkin & allergy
Outcomes
Euthanized

USA-USFDACVM-2025-US-074363

Received 2025-12-14 · MSK · MSK

Serious
Species
Dog
Breed
Retriever - Labrador
Size / weight
50-99 lb (37.8 Kilogram)
Age
8+ years (11.3 Year)
Sex
Male Neutered
Region
USA
Reactions
WoundLick granulomaExternal ear disorder NOSPerianal inflammationMusculoskeletal disorder NOSHeavy breathingPantingDecreased appetiteScootingActive urine sedimentFungal skin infection NOSSkin lesion NOSLack of efficacy - NOS
Body systems
OtherDigestiveEffectiveness
Outcomes
Ongoing

USA-USFDACVM-2025-US-072888

Received 2025-12-11 · MSK · MSK

Serious
Species
Cat
Breed
Domestic Longhair
Size / weight
10-24 lb (5.715 Kilogram)
Age
8+ years (14 Year)
Sex
Male Neutered
Region
USA
Reactions
SyncopeCollapse NOS (see also Cardio-vascular and Neurological disorders)AnorexiaHidingLow blood pressureHepatomegalyHepato-biliary disorder NOSIntentional misuse
Body systems
OtherNeurologicDigestive
Outcomes
Ongoing

USA-USFDACVM-2025-US-072505

Received 2025-12-11 · MSK · MSK

Serious
Species
Dog
Breed
Terrier - Bull - Staffordshire
Size / weight
50-99 lb (30.935 Kilogram)
Age
4-7 years (4 Year)
Sex
Female Neutered
Region
USA
Reactions
EmesisRegurgitationNauseaGastric distensionMedication error NOSAbnormal radiograph finding
Body systems
DigestiveOther
Outcomes
Ongoing

USA-USFDACVM-2025-US-074006

Received 2025-12-10 · MSK · MSK

Non-serious
Species
Cat
Breed
Domestic Shorthair
Size / weight
10-24 lb (4.6 Kilogram)
Age
4-7 years (6 Year)
Sex
Male Neutered
Region
USA
Reactions
Diarrhoea
Body systems
Digestive
Outcomes
Outcome Unknown

USA-USFDACVM-2025-US-073465

Received 2025-12-05 · MSK · MSK

Serious
Species
Dog
Breed
Retriever - Labrador
Size / weight
50-99 lb (31.8 Kilogram)
Age
8+ years (14 Year)
Sex
Female Neutered
Region
USA
Reactions
Watery diarrhoea
Body systems
Digestive
Outcomes
Outcome Unknown

USA-USFDACVM-2025-US-072729

Received 2025-12-05 · MSK · MSK

Non-serious
Species
Dog
Breed
Terrier - Bull
Size / weight
25-49 lb (17.6 Kilogram)
Age
4-7 years (7 Year)
Sex
Female Neutered
Region
USA
Reactions
Leucopenia NOSAnaemia NOSHypoalbuminaemiaNeutropeniaPyodermaReduced globulinsHypophosphataemiaNon-regenerative anaemiaLow serum alkaline phosphatase (ALP)Pale mucous membraneElevated alanine aminotransferase (ALT)Decreased packed cell volume (PCV)Lethargy (see also Central nervous system depression in Neurological)HypocalcaemiaElevated aspartate aminotransferase (AST)HypoproteinaemiaProteinuriaElectrolyte disorderDisorder of red blood cell NOSElevated creatine-kinase (CK)Other coagulation investigation abnormalityIncreased band neutrophiliaElevated mean corpuscular volume (MCV)LymphopeniaOther abnormal test result NOSDiarrhoeaPanleucopeniaEosinopeniaDecreased haematocritIncreased percentage reticulocytes
Body systems
OtherNeurologicDigestive
Outcomes
Ongoing

USA-USFDACVM-2025-US-072504

Received 2025-12-04 · MSK · MSK

Serious
Species
Dog
Breed
Terrier - Bull - American Pit
Size / weight
50-99 lb (29.03 Kilogram)
Age
1-3 years (2 Year)
Sex
Male Neutered
Region
USA
Reactions
Otitis externaTrigeminus paralysisVomitingCoughMuscle atrophy (see also Muscle wasting)Elevated serum alkaline phosphatase (ALP)Elevated alanine aminotransferase (ALT)HypersalivationUnusual stool colourErythema (for urticaria see Immune SOC)Elevated gamma-glutamyl transferase (GGT)Elevated total bilirubinAbnormal ultrasound findingHepatic fibrosisHepatitisLethargy (see also Central nervous system depression in Neurological)AngioedemaGeneralised rashDyspnoeaIncreased lung soundsLeucocytosis NOSIcterusAbnormal radiograph findingJaw disorder
Body systems
OtherDigestiveSkin & allergyNeurologic
Outcomes
Ongoing

USA-USFDACVM-2025-US-072145

Received 2025-12-03 · MSK · MSK

Serious
Species
Cat
Breed
Domestic Shorthair
Size / weight
10-24 lb (5.897 Kilogram)
Age
4-7 years (5 Year)
Sex
Male Neutered
Region
USA
Reactions
Weight lossDecreased appetiteVomiting
Body systems
OtherDigestive
Outcomes
Ongoing

USA-USFDACVM-2025-US-072463

Received 2025-12-01 · MSK · MSK

Non-serious
Species
Dog
Breed
['Rottweiler', 'Retriever - Labrador']
Size / weight
50-99 lb (27.76 Kilogram)
Age
8+ years (14 Year)
Sex
Male Neutered
Region
USA
Reactions
Proprioception deficitMusculoskeletal disorder NOSLethargy (see also Central nervous system depression in Neurological)AnorexiaReluctant to moveBradycardiaArrhythmiaPyrexiaLymphocytosisLeucocytosis NOSLow thyroxine (T4)Elevated symmetrical dimethylarginine (SDMA)Urinary tract infection
Body systems
OtherNeurologicDigestive
Outcomes
Ongoing

USA-USFDACVM-2025-US-072107

Received 2025-12-01 · MSK · MSK

Serious
Species
Dog
Breed
Shepherd Dog - German
Size / weight
50-99 lb (40.1 Kilogram)
Age
8+ years (10.5 Year)
Sex
Male Neutered
Region
USA
Reactions
VocalisationAbnormal tail posturePain NOSWeight lossDecreased appetiteVomitingChewing disorderPantingTremblingLying downAnxietyExcessive chewing, licking and/or groomingMuscle atrophy (see also Muscle wasting)Musculoskeletal disorder NOSAbnormal radiograph findingSpondylosisJoint effusionElevated gamma-glutamyl transferase (GGT)LymphopeniaLethargy (see also Central nervous system depression in Neurological)Thoracic painDeath by euthanasiaMedication error NOS
Body systems
OtherDigestiveBehaviorNeurologic
Outcomes
Euthanized

USA-USFDACVM-2025-US-072073

Received 2025-12-01 · MSK · MSK

Non-serious
Species
Dog
Breed
Shih Tzu
Size / weight
10-24 lb (4.536 Kilogram)
Age
1-3 years (1 Year)
Sex
Female Neutered
Region
USA
Reactions
Necrotic woundSkin lesion NOSLocal erythemaAnorexiaDiarrhoeaAbdominal discomfortDehydrationBacterial skin infection NOS
Body systems
OtherDigestive
Outcomes
Ongoing

USA-USFDACVM-2025-US-075298

Received 2025-11-28 · MSK · MSK

Non-serious
Species
Dog
Breed
Dachshund - Miniature
Size / weight
10-24 lb (6.07 Kilogram)
Age
4-7 years (5.25 Year)
Sex
Male Neutered
Region
USA
Reactions
Haemorrhagic gastroenteritisLack of efficacy (endoparasite) - roundworm NOSDiarrhoeaEar infection NOSHypochloraemiaSneezingVomiting
Body systems
OtherEffectivenessDigestive
Outcomes
Ongoing

USA-USFDACVM-2025-US-074731

Received 2025-11-25 · MSK · MSK

Non-serious
Species
Dog
Breed
Retriever - Labrador
Size / weight
50-99 lb (44.452 Kilogram)
Age
8+ years (9 Year)
Sex
Female Neutered
Region
USA
Reactions
VomitingNot eatingLow platelet count
Body systems
DigestiveOther
Outcomes
Outcome Unknown

USA-USFDACVM-2025-US-069774

Received 2025-11-25 · MSK · MSK

Non-serious
Species
Dog
Breed
Dachshund - Miniature
Size / weight
10-24 lb (6.07 Kilogram)
Age
4-7 years (5.25 Year)
Sex
Male Neutered
Region
USA
Reactions
Haemorrhagic gastroenteritisLack of efficacy (endoparasite) - roundworm NOSDiarrhoeaEar infection NOSHypochloraemiaSneezingVomiting
Body systems
OtherEffectivenessDigestive
Outcomes
Ongoing

USA-USFDACVM-2025-US-075182

Received 2025-11-24 · MSK · MSK

Serious
Species
Cat
Breed
Domestic Shorthair
Size / weight
10-24 lb (4.76 Kilogram)
Age
8+ years (11 Year)
Sex
Male Neutered
Region
USA
Reactions
Cold feeling to the touchDecreased appetiteLack of efficacy - NOSBehavioural disorder NOSVomitingRenal disorder NOSLethargy (see also Central nervous system depression in Neurological)Elevated renal parametersArthritisReluctant to moveWeight gainWobblinessDental diseaseRespiratory tract infection NOSAnaemia NOSElevated creatinineHypercalcaemiaFeverDehydrationDiarrhoeaDecreased haematocritDecreased red blood cell countDigestive tract disorder NOSSicknessDistressDiabetesDecreased body temperatureDeath by euthanasia
Body systems
OtherDigestiveEffectivenessBehaviorNeurologic
Outcomes
Euthanized

USA-USFDACVM-2025-US-069596

Received 2025-11-24 · MSK · MSK

Serious
Species
Cat
Breed
Domestic Shorthair
Size / weight
10-24 lb (6.2 Kilogram)
Age
8+ years (13 Year)
Sex
Male Neutered
Region
USA
Reactions
Not eatingVomitingCardiac enlargementSplenomegalyAbnormal ultrasound findingHaematuriaPyuriaNon-regenerative anaemiaDecreased haematocritHypokalaemiaBladder distensionDehydrationElevated creatinineNot urinatingIntentional misuseUrinary tract disorder NOS
Body systems
OtherDigestive
Outcomes
Ongoing

USA-USFDACVM-2025-US-070121

Received 2025-11-21 · MSK · MSK

Non-serious
Species
Dog
Breed
['Shepherd Dog - German', 'Dog (unknown)']
Size / weight
50-99 lb (36.015 Kilogram)
Age
8+ years (12 Year)
Sex
Male Neutered
Region
USA
Reactions
Lethargy (see also Central nervous system depression in Neurological)Decreased appetiteWobblinessNot himself/herself
Body systems
NeurologicDigestiveOther
Outcomes
Ongoing

USA-USFDACVM-2025-US-067364

Received 2025-11-14 · MSK · MSK

Serious
Species
Cat
Breed
Domestic Shorthair
Size / weight
10-24 lb (6.804 Kilogram)
Age
8+ years (14 Year)
Sex
Female Unknown
Region
USA
Reactions
DehydrationEmesis (multiple)Elevated cholesterol (total)Abnormal radiograph findingLack of efficacy - NOSWeaknessUrinary incontinenceAtaxiaDullRecumbencyIncreased coagulation timeElevated aspartate aminotransferase (AST)Elevated creatinineHypokalaemiaElevated gamma-glutamyl transferase (GGT)Elevated triglycerideBlood in urineHypothermiaDisseminated intravascular coagulationCardiorespiratory arrestDeathIntentional misuseShockDistension of abdomen
Body systems
OtherDigestiveEffectivenessNeurologic
Outcomes
Died

USA-USFDACVM-2025-US-067000

Received 2025-11-14 · MSK · MSK

Serious
Species
Cat
Breed
Domestic Shorthair
Size / weight
Under 10 lb (3.992 Kilogram)
Age
8+ years (13 Year)
Sex
Female Unknown
Region
USA
Reactions
DiarrhoeaDecreased appetiteLethargy (see also Central nervous system depression in Neurological)Bloody diarrhoeaDry mucous membraneOpen mouth breathingUnresponsive to stimuliDecreased haematocritIncreased percentage reticulocytesRegenerative anaemiaIntentional misuseUnderdoseThrombocytopeniaHeart murmurHypersalivation
Body systems
DigestiveNeurologicOther
Outcomes
Ongoing

USA-USFDACVM-2025-US-069686

Received 2025-11-12 · MSK · MSK

Serious
Species
Cat
Breed
Domestic Shorthair
Size / weight
Under 10 lb (3.9 Kilogram)
Age
8+ years (14 Year)
Sex
Female Neutered
Region
USA
Reactions
Swollen limbEpistaxisDeath by euthanasiaMalaiseHeart murmurNeutropeniaThrombocytopeniaHypoalbuminaemiaIncreased drinkingHaematuriaDecreased urine concentrationElevated protein:creatinine ratioDehydrationLymphopeniaAbdominal painIntestinal disorder NOSAbnormal radiograph findingRenal failureRenal disorder NOSInflammatory bowel disorderBronchopulmonary inflammationBruisingAnaemia NOSTachycardiaPale mucous membraneElevated alanine aminotransferase (ALT)Prolonged one stage prothrombin time (OSPT)Intentional misuseMedication error NOSPolyuriaAnorexiaAzotaemiaNecropsy performedHaemorrhage NOSFractureThyroid adenomaPancreas disorder
Body systems
OtherDigestive
Outcomes
Euthanized

USA-USFDACVM-2025-US-068234

Received 2025-11-12 · MSK · MSK

Serious
Species
Cat
Breed
Cat (unknown)
Sex
Mixed Unknown
Region
USA
Reactions
DeathHaematocheziaDecreased appetiteRegurgitationLethargy (see also Central nervous system depression in Neurological)DiarrhoeaDeath by euthanasia
Body systems
OtherDigestiveNeurologic
Outcomes
DiedEuthanizedOutcome Unknown

USA-USFDACVM-2025-US-068187

Received 2025-11-03 · MSK · MSK

Non-serious
Species
Cat
Breed
Domestic Shorthair
Size / weight
10-24 lb (5.1 Kilogram)
Age
4-7 years (7 Year)
Sex
Male Neutered
Region
USA
Reactions
Hypersalivation
Body systems
Digestive
Outcomes
Outcome Unknown

Tap or hover a reaction to see what it means in plain language.

Tracked signals
32
Reported cases
60
Serious reports
7
Species represented
2
Grouped by Body System
Effectiveness (1) · Lack of efficacy (endoparasite) - tapeworm Other (31) · Thrombocytopenia, Elevated symmetrical dimethylarginine, Conjunctivitis
Most Reported Reactions
Reaction Body system Cases Species Serious cases
Other 4 Dog 0
Other 4 Dog 0
Other 3 Dog 0
Other 2 Dog 0
Other 2 Dog 0
Other 2 Dog 0
Other 2 Dog 0
Other 2 Dog 0

Species coverage: Dog (48) Cat (12)

View detailed reaction table
Reaction Body system Species Seriousness Frequency Reports
Other Dog Unknown - 4
Other Dog Unknown - 4
Other Dog Unknown - 3
Other Dog Unknown - 2
Other Dog Unknown - 2
Other Dog Unknown - 2
Other Dog Unknown - 2
Other Dog Unknown - 2
Other Dog Unknown - 2
Other Dog Unknown - 2
Other Dog Unknown - 2
Other Dog Unknown - 2
Effectiveness Dog Unknown - 2
Other Dog Unknown - 2
Other Dog Unknown - 2
Other Cat Unknown - 2
Other Cat Unknown - 2
Other Dog Unknown - 2
Other Dog Unknown - 2
Other Cat Unknown - 2
Other Cat Unknown - 2
Other Cat Unknown - 2
Other Dog Unknown - 2
Other Cat Serious - 1
Other Dog Non-serious - 1
Other Cat Serious - 1
Other Dog Unknown - 1
Other Dog Serious - 1
Other Dog Serious - 1
Other Dog Serious - 1
Other Dog Serious - 1
Other Dog Serious - 1
Source metadata:

Storage & Handling

Store at room temperature.

Source Documents

The most useful source links appear first; full previews and metadata stay in the veterinary/professional layer.

Use original documents to confirm product-specific warnings, ingredients, and handling details with your veterinarian.

Gabapentin SPL SPL · Structured Product Label Gabapentin SPL SPL · Structured Product Label SolutitionKits SPL SPL · Structured Product Label

Full source previews and metadata remain in the veterinary/professional layer.

Owner handouts

0
No owner handouts linked yet.

Official label / PI

0
No official label or package insert links yet.

SPL

4

FOI

0
No FOI links yet.

Gabapentin SPL

SPL · Structured Product Label

Open original
FDA Structured Product Label XML for Gabapentin. Use the source link for the full official labeling record.

Gabapentin SPL

SPL · Structured Product Label

Open original
FDA Structured Product Label XML for Gabapentin. Use the source link for the full official labeling record.

SolutitionKits SPL

SPL · Structured Product Label

Open original
FDA Structured Product Label XML for SolutitionKits. Use the source link for the full official labeling record.

GABAPENTIN SPL

SPL · Structured Product Label

Open original
FDA Structured Product Label XML for GABAPENTIN. Use the source link for the full official labeling record.
Source metadata:
Veterinary reference (advanced)

Canonical medication sections are above. This legacy block remains available for deeper cross-reference without cluttering the primary workflow.

At a Glance

Quick facts and links to official labeling and safety signals.

Data freshness
  • Reference facts: Source Roxee | Refreshed Aug 6, 2026, 7:47 PM UTC
    The reference fact projection used for browse cards and quick facts.
  • Animal Drug Product Listing Directory (NDC): Source FDA | Refreshed Aug 6, 2026, 7:47 PM UTC
    Package/product NDCs from FDA’s electronic listing directory (XLS).
  • openFDA reaction terms: Source FDA openFDA | Refreshed Aug 6, 2026, 7:52 PM UTC
  • openFDA case summaries: Source FDA openFDA | Refreshed Aug 6, 2026, 7:52 PM UTC
Official (FDA)
Identity: Generic ingredient • FDA branded products available
Official FDA brands: GABAPENTIN Gabapentin SolutitionKits
Manufacturer mapping: Multiple FDA labelers
Case-reported brands (openFDA): MSK
Catalog species: Both
NDC: Packages 46144-600-01 62157-711-01 73377-176-01 86032-041-01 • Products 46144 62157 73377 86032
Safety (openFDA)
Top reactions: Dog 382 • Cat 273 • View
Case summaries: 164 (showing 8) • View
openFDA reports are unverified and do not prove causation.
Explore
Related conditions: Pain (acute, chronic)
Linked using: Usage_Inferred (0.78)
Diagnosis Codes

Diagnosis-code mappings are not available for this medication yet.

Counseling and Monitoring Highlights

Global Pet owner/Vet mode is controlled in the header. This section avoids duplicate in-page persona tabs.

Owner-facing counseling points
  • Use caution with kidney disease; dose adjustments may be needed. (Contraindication, High)
Top reaction signals
Thrombocytopenia (4) Elevated symmetrical dimethylarginine (4) Conjunctivitis (3) Urolithiasis (2) Unclassifiable adverse event (2) Trembling (2) Skin lesion NOS (2) Respiratory tract infection NOS (2)

Identifiers & Packages

Normalized identifiers (NDC/NADA/ANADA) and package metadata from regulator listings.

Identifiers
NDC Package: 46144-600-01 NDC Package: 62157-711-01 NDC Package: 73377-176-01 NDC Package: 86032-041-01 NDC Product: 46144 NDC Product: 62157 NDC Product: 73377 NDC Product: 86032
Package NDC Product NDC Form / Route Status
46144-600-01 46144 -
62157-711-01 62157 -
73377-176-01 73377 -
86032-041-01 86032 -

Enriched Documents

Documents are tiered by source trust: Official, Clinical, Manufacturer, Marketing.

  • Gabapentin SPL • Structured Product Label • Official
    FDA Structured Product Label from the electronic animal drug product listing directory.
  • Gabapentin SPL • Structured Product Label • Official
    FDA Structured Product Label from the electronic animal drug product listing directory.
  • SolutitionKits SPL • Structured Product Label • Official
    FDA Structured Product Label from the electronic animal drug product listing directory.
  • GABAPENTIN SPL • Structured Product Label • Official
    FDA Structured Product Label from the electronic animal drug product listing directory.

Data Sources & Change Log

Every non-trivial field is expected to include provenance and update timestamps.

Official 4 Clinical 120 Manufacturer 0 Marketing 0

Marketing/Manufacturer content exists: 1 linked manufacturer ad video are attached to this medication.

Current Field Facts
  • contraindications: Use caution with kidney disease; dose adjustments may be needed. (Clinical, 2026-07-22)
  • contraindications: Use caution with kidney disease; dose adjustments may be needed. (Clinical, 2026-07-22)
  • contraindications: Use caution with kidney disease; dose adjustments may be needed. (Clinical, 2026-07-22)
  • contraindications: Use caution with kidney disease; dose adjustments may be needed. (Clinical, 2026-07-20)
  • contraindications: Use caution with kidney disease; dose adjustments may be needed. (Clinical, 2026-07-19)
  • contraindications: Use caution with kidney disease; dose adjustments may be needed. (Clinical, 2026-07-16)
  • contraindications: Use caution with kidney disease; dose adjustments may be needed. (Clinical, 2026-07-16)
  • contraindications: Use caution with kidney disease; dose adjustments may be needed. (Clinical, 2026-07-13)
  • contraindications: Use caution with kidney disease; dose adjustments may be needed. (Clinical, 2026-07-12)
  • contraindications: Use caution with kidney disease; dose adjustments may be needed. (Clinical, 2026-07-11)
  • contraindications: Use caution with kidney disease; dose adjustments may be needed. (Clinical, 2026-07-11)
  • contraindications: Use caution with kidney disease; dose adjustments may be needed. (Clinical, 2026-07-11)
  • contraindications: Use caution with kidney disease; dose adjustments may be needed. (Clinical, 2026-07-10)
  • contraindications: Use caution with kidney disease; dose adjustments may be needed. (Clinical, 2026-07-07)
  • contraindications: Use caution with kidney disease; dose adjustments may be needed. (Clinical, 2026-07-06)
  • contraindications: Use caution with kidney disease; dose adjustments may be needed. (Clinical, 2026-07-06)
  • contraindications: Use caution with kidney disease; dose adjustments may be needed. (Clinical, 2026-07-03)
  • contraindications: Use caution with kidney disease; dose adjustments may be needed. (Clinical, 2026-07-03)
  • contraindications: Use caution with kidney disease; dose adjustments may be needed. (Clinical, 2026-07-02)
  • contraindications: Use caution with kidney disease; dose adjustments may be needed. (Clinical, 2026-07-01)
Recent Revisions
  • side_effects updated 2026-07-22 19:08 by etl_backfill • Backfilled from existing medication fields
  • contraindications updated 2026-07-22 19:08 by etl_backfill • Backfilled from existing medication fields
  • usage updated 2026-07-22 19:08 by etl_backfill • Backfilled from existing medication fields
  • side_effects updated 2026-07-22 18:40 by etl_backfill • Backfilled from existing medication fields
  • contraindications updated 2026-07-22 18:40 by etl_backfill • Backfilled from existing medication fields
  • usage updated 2026-07-22 18:40 by etl_backfill • Backfilled from existing medication fields
  • side_effects updated 2026-07-22 08:29 by etl_backfill • Backfilled from existing medication fields
  • contraindications updated 2026-07-22 08:29 by etl_backfill • Backfilled from existing medication fields
  • usage updated 2026-07-22 08:29 by etl_backfill • Backfilled from existing medication fields
  • side_effects updated 2026-07-20 10:05 by etl_backfill • Backfilled from existing medication fields
  • contraindications updated 2026-07-20 10:05 by etl_backfill • Backfilled from existing medication fields
  • usage updated 2026-07-20 10:05 by etl_backfill • Backfilled from existing medication fields
  • side_effects updated 2026-07-19 13:48 by etl_backfill • Backfilled from existing medication fields
  • contraindications updated 2026-07-19 13:48 by etl_backfill • Backfilled from existing medication fields
  • usage updated 2026-07-19 13:48 by etl_backfill • Backfilled from existing medication fields
  • side_effects updated 2026-07-16 16:34 by etl_backfill • Backfilled from existing medication fields
  • contraindications updated 2026-07-16 16:34 by etl_backfill • Backfilled from existing medication fields
  • usage updated 2026-07-16 16:34 by etl_backfill • Backfilled from existing medication fields
  • side_effects updated 2026-07-16 15:43 by etl_backfill • Backfilled from existing medication fields
  • contraindications updated 2026-07-16 15:43 by etl_backfill • Backfilled from existing medication fields

FDA Products & Applications (Animal Drugs @ FDA)

Official sponsor/proprietary-name/application-status records linked by active ingredient.

Product Sponsor Application Status Published

Data source: FDA Animal Drugs @ FDA (public search export).

Usage

Used for neuropathic pain and as an adjunct for seizure control; also used for situational anxiety/sedation in some cases.

Contraindications

Use caution with kidney disease; dose adjustments may be needed.

Side Effects

Sedation, ataxia, mild GI upset.

Source: FDA openFDA • Reference

Top Reported Reactions (openFDA)

De-duplicated reaction terms grouped by body system from FDA openFDA reports (not verified; does not prove causation).

Effectiveness
Lack of efficacy (endoparasite) - tapeworm (2) • Dog

Showing top 5 for Effectiveness.

Other
Thrombocytopenia (4) • Dog Elevated symmetrical dimethylarginine (4) • Dog Conjunctivitis (3) • Dog Urolithiasis (2) • Dog Unclassifiable adverse event (2) • Dog
Show more (26)
Trembling (2) • Dog Skin lesion NOS (2) • Dog Respiratory tract infection NOS (2) • Dog Regurgitation (2) • Dog Reduced globulins (2) • Dog Pyoderma (2) • Dog Proprioception deficit (2) • Dog Knuckling (2) • Dog Hypophosphataemia (2) • Dog Hypokalaemia (2) • Cat Hepatomegaly (2) • Cat Fracture (2) • Dog Erythema (2) • Dog Elevated alanine aminotransferase (2) • Cat Decreased activity (2) • Cat Death (2) • Cat Confusion (2) • Dog Abnormal radiograph finding (1) • Cat Abnormal movement NOS (1) • Dog Abnormal menace reflex test (1) • Cat Abnormal histology NOS (1) • Dog Abnormal cytology (1) • Dog Abdominal pain (1) • Dog Abdominal effusion (1) • Dog Abdominal discomfort (1) • Dog Abdominal cavity disorder NOS (1) • Dog

Showing top 5 for Other.

Data source: FDA openFDA Animal & Veterinary adverse event reports.

Adverse Event Case Summaries (openFDA)

These are individual FDA adverse event reports. They are unverified and do not prove the medication caused the reaction.

Cat, Domestic Shorthair, Female, 11 year, 3.992 kilogram • Drug: MSK, Unassigned, Oral • Reactions: Facial pruritus, Medication error NOS • Outcome: Recovered/Normal

  • Report ID: USA-USFDACVM-2026-US-014454
  • Serious AE: No
  • Treated For AE: No
  • Sex: Female
  • Age: 11.00 Year
  • Weight: 3.992 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Oral
  • Form: Unassigned
Reactions Reported:
Facial pruritus Medication error NOS
Outcomes: Recovered/Normal

Dog, Retriever - Labrador, Male, 11 year, 47.174 kilogram • Drug: MSK, Unassigned, Unknown • Reactions: Partial lack of efficacy • Outcome: Ongoing

  • Report ID: USA-USFDACVM-2026-US-014361
  • Serious AE: Yes
  • Treated For AE: Yes
  • Sex: Male
  • Age: 11.00 Year
  • Weight: 47.174 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Unknown
  • Form: Unassigned
Reactions Reported:
Partial lack of efficacy
Outcomes: Ongoing

Dog, Schnauzer - Miniature, Male, 5 year, 10.16 kilogram • Drug: MSK, Unassigned, Oral • Reactions: Lameness, Wobbliness, Tiredness (lethargy), Unable to walk, Weakness… • Outcome: Ongoing

  • Report ID: USA-USFDACVM-2026-US-014449
  • Serious AE: Yes
  • Treated For AE: Yes
  • Sex: Male
  • Age: 5.00 Year
  • Weight: 10.160 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Oral
  • Form: Unassigned
Reactions Reported:
Lameness Wobbliness Tiredness (lethargy) Unable to walk Weakness Fever Immune-mediated polyarthritis Gastritis Abdominal cavity disorder NOS Abnormal ultrasound finding Hyperproteinaemia Lymphopenia Eosinopenia Medication error NOS
Outcomes: Ongoing

Dog, Crossbred Canine/dog, Male, 10 year, 32.205 kilogram • Drug: MSK, Unassigned, Unknown • Reactions: Musculoskeletal disorder NOS, Aggression, Unable to walk, Urinary incontinence, Melaena… • Outcome: Euthanized

  • Report ID: USA-USFDACVM-2026-US-014374
  • Serious AE: Yes
  • Treated For AE: Yes
  • Sex: Male
  • Age: 10.00 Year
  • Weight: 32.205 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Unknown
  • Form: Unassigned
Reactions Reported:
Musculoskeletal disorder NOS Aggression Unable to walk Urinary incontinence Melaena Vomiting Tiredness (lethargy) Death by euthanasia Neurological signs NOS
Outcomes: Euthanized

Dog, Retriever - Labrador, Unknown • Drug: MSK, Unknown • Reactions: Death • Outcome: Died

  • Report ID: USA-USFDACVM-2026-US-014204
  • Serious AE: Yes
  • Treated For AE: No
  • Sex: Unknown
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Unknown
Reactions Reported:
Death
Outcomes: Died

Cat, Domestic Shorthair, Female, 20 year, 2.631 kilogram • Drug: MSK, Unassigned, Unknown • Reactions: Agitation, Vocalisation, Unsteady walking (ataxia), Weakness • Outcome: Recovered/Normal

  • Report ID: USA-USFDACVM-2026-US-014011
  • Serious AE: Yes
  • Treated For AE: Yes
  • Sex: Female
  • Age: 20.00 Year
  • Weight: 2.631 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Unknown
  • Form: Unassigned
Reactions Reported:
Agitation Vocalisation Unsteady walking (ataxia) Weakness
Outcomes: Recovered/Normal

Dog, Retriever - Golden, Female, 4 year, 34.019 kilogram • Drug: MSK, Unassigned, Unknown, Dose: 300 Milligram per animal, Frequency: 12 per hour • Reactions: Lameness, Difficulty to rise, Joint swelling, Abnormal radiograph finding, Bone and joint disorder NOS… • Outcome: Ongoing

  • Report ID: USA-USFDACVM-2026-US-014065
  • Serious AE: Yes
  • Treated For AE: Yes
  • Sex: Female
  • Age: 4.00 Year
  • Weight: 34.019 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Unknown
  • Form: Unassigned
  • Dose: 300 Milligram per animal
  • Frequency: 12 per hour
Reactions Reported:
Lameness Difficulty to rise Joint swelling Abnormal radiograph finding Bone and joint disorder NOS Discomfort NOS
Outcomes: Ongoing

Dog, Shepherd Dog - German, Female, 9 year, 35.698 kilogram • Drug: MSK, Unassigned, Oral, Dose: 200 Milligram per animal, Frequency: 12 per hour • Reactions: Joint pain, Lameness, Depression, Difficulty standing, Decreased appetite… • Outcome: Outcome Unknown

  • Report ID: USA-USFDACVM-2026-US-014048
  • Serious AE: Yes
  • Treated For AE: Yes
  • Sex: Female
  • Age: 9.00 Year
  • Weight: 35.698 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Oral
  • Form: Unassigned
  • Dose: 200 Milligram per animal
  • Frequency: 12 per hour
Reactions Reported:
Joint pain Lameness Depression Difficulty standing Decreased appetite Abnormal radiograph finding Bone and joint disorder NOS Joint effusion Spondylosis
Outcomes: Outcome Unknown

Data source: FDA openFDA Animal & Veterinary adverse event reports.

Overdose Information

Overdose can cause severe sedation, loss of coordination, muscle tremors, and respiratory depression. Emergency care: IV fluids, monitoring.

Storage & Handling

Store at room temperature.

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