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Roxee Medication Guide

Lokivetmab

Medication reference facts with explicit FDA-approval, off-label, source-limited, and safety context. Roxee does not sell, prescribe, or dispense medications.

Dog Source review pending Source coverage pending Owner quick guide first
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Data freshness

Reference facts
Source review pending
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Roxee is still reviewing source support for this medication profile.

FDA applications
Regulatory match pending
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Roxee has safety or ingredient evidence for this medication, but a regulatory product/application match is still pending.

Safety reports
Safety data refreshed
Jun 13, 2026, 11:29 a.m.

openFDA reaction terms and case summaries are supporting evidence, not proof of causality.

Source timing details
Source timing details
  • Reference facts: Source Roxee | Refreshed Jun 23, 2026, 10:05 AM UTC
    The reference fact projection used for browse cards and quick facts.
  • openFDA reaction terms: Source FDA openFDA | Refreshed Jun 23, 2026, 10:04 AM UTC
  • openFDA case summaries: Source FDA openFDA | Refreshed Jun 23, 2026, 10:04 AM UTC
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Lokivetmab

Lokivetmab

Drug type: Generic ingredient • Generic profile • Source coverage pending

Dog 85% reference complete

Species: Dog

Approval status: Source coverage pending. Roxee has limited supporting content for this record, but no on-page official FDA animal-drug document is linked yet. Treat it as source-limited until the ETL backfill adds official coverage.

Medication Snapshot

Merged from the current Roxee medication system with field-level provenance, freshness, and completeness tracking.

Lokivetmab

Monoclonal antibody used to reduce itch associated with atopic dermatitis in dogs. Species commonly shown: Dog.

Generic name
Lokivetmab
Species
Dog
Completeness
85%
Validation
Incomplete

Indications / Uses

Monoclonal antibody used to reduce itch associated with atopic dermatitis in dogs.

Administration / How To Give

Injectable

Storage

Refrigerate and protect from light; do not freeze.

Warnings / Contraindications

Discuss use in dogs with a history of severe allergic reactions.

  • Discuss use in dogs with a history of severe allergic reactions.

Side Effects

Injection site reactions, lethargy; generally well tolerated.

FAQ

Dog

Refrigerate and protect from light; do not freeze.

Related Medications

Cyclosporine Same category: Allergies / Itching Diphenhydramine Same category: Allergies / Itching Oclacitinib Same category: Allergies / Itching Oclacitinib Maleate Same category: Allergies / Itching Prednisone Same category: Allergies / Itching Meloxicam Same category: Allergies / Itching

Related Conditions

Atopic Dermatitis (Canine Atopy)

Source Transparency

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Pet Owner Quick Guide

Start here first for the safest next-step summary before the deeper medication detail.

Used for:

Monoclonal antibody used to reduce itch associated with atopic dermatitis in dogs.

Dosing note:

Exact dosing depends on your pet's species, weight, and health status. Use your veterinarian's instructions for the exact dose and schedule.

What to watch for:

  • Discuss use in dogs with a history of severe allergic reactions
  • very low energy (1 reports)
  • Pinnal ulcer (1 reports)
  • Not himself/herself (1 reports)

When to call the vet:

  • Repeated vomiting or diarrhea.
  • Severe lethargy (hard to wake, very low energy).
  • Collapse or fainting.
  • Trouble breathing.
  • Facial swelling or hives.
  • Blood in vomit or stool.

What to tell or ask your vet today:

  • Is this medicine the right fit for my pet’s current symptoms?
  • Which warning signs mean I should call back right away?
  • How should I handle missed doses or refusal to take the medicine?

Next actions

Talk to a Vet / Find a Vet Near You Save to pet meds Share page Review report evidence
Research brief

Medication Research Insights

A source-aware map of what to know, what is uncertain, and what to verify with your veterinarian.

Source Backed Signals

What to know

Evidence-backed context Limited

Roxee has limited cited overview evidence for Lokivetmab; use the official documents and your veterinarian's instructions for product-specific decisions.

Source: openFDA case USA-USFDACVM-2025-US-069486
Safety signal coverage Reported signals

32 tracked reaction signals; 32 reported cases; 22 serious reports; 1 species group. These are reporting and label-derived signals for interpretation with a veterinarian.

Source: openFDA case USA-USFDACVM-2025-US-069486
Interpretation guardrail Not causation

Adverse-event reports help form a watch list, but they do not prove the medication caused the reaction and they are not a risk ranking between medications.

Evidence tension

Stronger signal Label / review

Official labels, package inserts, and reviewed summaries carry more weight than isolated reports.

Source: openFDA case USA-USFDACVM-2025-US-069486
Weaker signal Reported data

Case reports and openFDA terms are useful for pattern awareness, but they are incomplete, can include multiple exposures, and do not estimate an individual pet's probability of harm.

Reaction signal map

Most reported reactions Top terms

Tiredness (lethargy) (1 reports), Pinnal ulcer (1 reports), Not himself/herself (1 reports), Low platelet count (1 reports), Loss of hearing (1 reports)

Body systems represented Signal grouping

Digestive (1), Skin & allergy (2), Neurologic (1), Other (28)

Explore supporting adverse reports

Species and breed lens

Species represented in reports Species lens

Dog (32 reports)

Breed metadata in reports Metadata only

Shepherd Dog - German (2), Terrier - Irish Soft-coated Wheaten (1), ['Schnauzer (unspecified)', 'Poodle - Miniature'] (1), ['Shih Tzu', 'Dog (unknown)'] (1). These are report metadata, not proof that a breed is at higher risk.

What your vet may verify

Fit for this patient Vet check

Verify whether Lokivetmab fits the pet's species, current diagnosis, age, weight, organ status, pregnancy/lactation status, and concurrent medications.

Evidence limitations Evidence review

Separate label-backed warnings from adverse-event reports and owner observations before changing the plan.

What to watch next

Watch list Owner-safe

Discuss use in dogs with a history of severe allergic reactions, very low energy, Pinnal ulcer, Not himself/herself

Call sooner if Escalation

Repeated vomiting or diarrhea. Severe lethargy (hard to wake, very low energy). Collapse or fainting.

Bottom line: Use this Lokivetmab brief as a structured watch list and source map, not as a reason to start, stop, or change treatment without your veterinarian.
Vet source depth
  1. openFDA case USA-USFDACVM-2025-US-069486 · adverse_reaction · adverse reactions
  2. Medication contraindications · safety_warning · warnings contraindications

Evidence

Review status / Updated / Sources

Review status: Clinical reviewer not listed

Updated: April 15, 2026, 10:04 AM UTC

Sources:
Safety & side effects

Side effects to monitor:

  • Discuss use in dogs with a history of severe allergic reactions
  • very low energy
  • Pinnal ulcer
  • Not himself/herself

Most reported reactions:

  • Tiredness (lethargy) (1 reports)
  • Pinnal ulcer (1 reports)
  • Not himself/herself (1 reports)
Explore reported case details

Emergency warning signs:

  • Repeated vomiting or diarrhea.
  • Severe lethargy (hard to wake, very low energy).
  • Collapse or fainting.
  • Trouble breathing.
Talk to a Vet / Find a Vet Near You Start Symptom Intake

Vet Fast Scan

Source-backed clinical checkpoints for quick review.

FDA-labeled species
Not linked yet
Indication / use
Monoclonal antibody used to reduce itch associated with atopic dermatitis in dogs.
Form / route / dose
Confirm product label and patient-specific plan.
Warnings
  • High: Discuss use in dogs with a history of severe allergic reactions.
Adverse-event caveat
openFDA adverse-event cases are reported signals. They are not verified, do not prove causation, and do not estimate a pet's individual risk.
Source docs
No source documents linked yet.

Quick Facts

Official label facts first, then secondary summaries. Marketing content is separated below.

Species: Dog
Manufacturer: Manufacturer not confirmed

Warnings / Contraindications

Discuss use in dogs with a history of severe allergic reactions.

  • High: Discuss use in dogs with a history of severe allergic reactions.
Source metadata:

Adverse Reactions

Snapshot first, detailed rows second. This section summarizes signal data and is not a diagnosis.

Reported case explorer

Filter stored openFDA reports by pet and report attributes. Counts describe reports in this data set, not risk.

Clear filters
openFDA adverse-event cases are reported signals. They are not verified, do not prove causation, and do not estimate a pet's individual risk.
Stored reports
6
Matching reports
1
Active filters
1
Selected filters
Body system: Neurologic Clear
Reset
Drill into common report signals
Not himself/herself (2) Abnormal adrenocorticotropic hormone (ACTH) stimulation test (1) Blood in urine (1) Confusion (1) Other (6) Digestive (2) Neurologic (1)
Showing up to 50 matching reports.

USA-USFDACVM-2025-US-065104

Received 2025-10-30 · MSK · MSK

Serious
Species
Dog
Breed
Shepherd Dog - German
Size / weight
50-99 lb (43.4 Kilogram)
Sex
Male Neutered
Region
USA
Reactions
Decreased appetiteLethargy (see also Central nervous system depression in Neurological)InappetenceElevated alanine aminotransferase (ALT)Elevated serum alkaline phosphatase (ALP)Decreased haematocritDecreased packed cell volume (PCV)Low platelet countDiscomfort NOSLoss of hearingLocalised oedema (not application site)Hearing decreased
Body systems
DigestiveNeurologicOther
Outcomes
Outcome Unknown

Tap or hover a reaction to see what it means in plain language.

Tracked signals
32
Reported cases
32
Serious reports
22
Species represented
1
Grouped by Body System
Digestive (1) · Decreased appetite Skin & allergy (2) · Itching, Application site itching Neurologic (1) · Tiredness (lethargy) Other (28) · Pollakiuria, Pinnal ulcer, Not himself/herself
Most Reported Reactions
Reaction Body system Cases Species Serious cases
Neurologic 1 Dog 1
Other 1 Dog 1
Other 1 Dog 1
Other 1 Dog 1
Other 1 Dog 1
Other 1 Dog 1
Other 1 Dog 1
Other 1 Dog 1

Species coverage: Dog (32)

View detailed reaction table
Reaction Body system Species Seriousness Frequency Reports
Neurologic Dog Serious - 1
Other Dog Non-serious - 1
Other Dog Serious - 1
Other Dog Serious - 1
Other Dog Serious - 1
Other Dog Serious - 1
Other Dog Serious - 1
Skin & allergy Dog Non-serious - 1
Other Dog Serious - 1
Other Dog Non-serious - 1
Other Dog Non-serious - 1
Other Dog Serious - 1
Other Dog Serious - 1
Other Dog Non-serious - 1
Other Dog Serious - 1
Other Dog Non-serious - 1
Other Dog Serious - 1
Other Dog Serious - 1
Other Dog Serious - 1
Other Dog Serious - 1
Other Dog Serious - 1
Other Dog Serious - 1
Other Dog Serious - 1
Digestive Dog Serious - 1
Other Dog Serious - 1
Other Dog Serious - 1
Other Dog Serious - 1
Other Dog Non-serious - 1
Other Dog Non-serious - 1
Skin & allergy Dog Non-serious - 1
Other Dog Serious - 1
Other Dog Non-serious - 1
Source metadata:

Storage & Handling

Refrigerate and protect from light; do not freeze.

Veterinary reference (advanced)

Canonical medication sections are above. This legacy block remains available for deeper cross-reference without cluttering the primary workflow.

At a Glance

Quick facts and links to official labeling and safety signals.

Data freshness
  • Reference facts: Source Roxee | Refreshed Jun 23, 2026, 10:05 AM UTC
    The reference fact projection used for browse cards and quick facts.
  • openFDA reaction terms: Source FDA openFDA | Refreshed Jun 23, 2026, 10:04 AM UTC
  • openFDA case summaries: Source FDA openFDA | Refreshed Jun 23, 2026, 10:04 AM UTC
Official (FDA)
Identity: Generic ingredient • No FDA branded products linked
No official FDA brand rows linked yet for this ingredient.
Case-reported brands (openFDA): MSK
Catalog species: Dog
Safety (openFDA)
Top reactions: Dog 26 • Cat 0 • View
Case summaries: 6 (showing 6) • View
openFDA reports are unverified and do not prove causation.
Explore
Related conditions: Atopic Dermatitis (Canine Atopy)
Linked using: Usage_Inferred (0.78)
Diagnosis Codes
ICD10_CM: L20.9
Atopic dermatitis, unspecified

Counseling and Monitoring Highlights

Global Pet owner/Vet mode is controlled in the header. This section avoids duplicate in-page persona tabs.

Owner-facing counseling points
  • Discuss use in dogs with a history of severe allergic reactions. (Contraindication, High)
Top reaction signals
Tiredness (lethargy) (1) Pinnal ulcer (1) Not himself/herself (1) Low platelet count (1) Loss of hearing (1) Localised oedema (1) Injection site pain (1) Inappetence (1)

Data Sources & Change Log

Every non-trivial field is expected to include provenance and update timestamps.

Official 0 Clinical 120 Manufacturer 0 Marketing 0
Current Field Facts
  • contraindications: Discuss use in dogs with a history of severe allergic reactions. (Clinical, 2026-06-23)
  • contraindications: Discuss use in dogs with a history of severe allergic reactions. (Clinical, 2026-06-22)
  • contraindications: Discuss use in dogs with a history of severe allergic reactions. (Clinical, 2026-06-22)
  • contraindications: Discuss use in dogs with a history of severe allergic reactions. (Clinical, 2026-06-21)
  • contraindications: Discuss use in dogs with a history of severe allergic reactions. (Clinical, 2026-06-20)
  • contraindications: Discuss use in dogs with a history of severe allergic reactions. (Clinical, 2026-06-13)
  • contraindications: Discuss use in dogs with a history of severe allergic reactions. (Clinical, 2026-06-12)
  • contraindications: Discuss use in dogs with a history of severe allergic reactions. (Clinical, 2026-06-12)
  • contraindications: Discuss use in dogs with a history of severe allergic reactions. (Clinical, 2026-06-11)
  • contraindications: Discuss use in dogs with a history of severe allergic reactions. (Clinical, 2026-06-11)
  • contraindications: Discuss use in dogs with a history of severe allergic reactions. (Clinical, 2026-06-10)
  • contraindications: Discuss use in dogs with a history of severe allergic reactions. (Clinical, 2026-06-08)
  • contraindications: Discuss use in dogs with a history of severe allergic reactions. (Clinical, 2026-06-07)
  • contraindications: Discuss use in dogs with a history of severe allergic reactions. (Clinical, 2026-06-06)
  • contraindications: Discuss use in dogs with a history of severe allergic reactions. (Clinical, 2026-06-05)
  • contraindications: Discuss use in dogs with a history of severe allergic reactions. (Clinical, 2026-06-04)
  • contraindications: Discuss use in dogs with a history of severe allergic reactions. (Clinical, 2026-06-03)
  • contraindications: Discuss use in dogs with a history of severe allergic reactions. (Clinical, 2026-06-02)
  • contraindications: Discuss use in dogs with a history of severe allergic reactions. (Clinical, 2026-06-01)
  • contraindications: Discuss use in dogs with a history of severe allergic reactions. (Clinical, 2026-06-01)
Recent Revisions
  • side_effects updated 2026-06-23 10:05 by etl_backfill • Backfilled from existing medication fields
  • contraindications updated 2026-06-23 10:05 by etl_backfill • Backfilled from existing medication fields
  • usage updated 2026-06-23 10:05 by etl_backfill • Backfilled from existing medication fields
  • side_effects updated 2026-06-22 10:45 by etl_backfill • Backfilled from existing medication fields
  • contraindications updated 2026-06-22 10:45 by etl_backfill • Backfilled from existing medication fields
  • usage updated 2026-06-22 10:45 by etl_backfill • Backfilled from existing medication fields
  • side_effects updated 2026-06-22 10:04 by etl_backfill • Backfilled from existing medication fields
  • contraindications updated 2026-06-22 10:04 by etl_backfill • Backfilled from existing medication fields
  • usage updated 2026-06-22 10:04 by etl_backfill • Backfilled from existing medication fields
  • side_effects updated 2026-06-21 05:18 by etl_backfill • Backfilled from existing medication fields
  • contraindications updated 2026-06-21 05:18 by etl_backfill • Backfilled from existing medication fields
  • usage updated 2026-06-21 05:18 by etl_backfill • Backfilled from existing medication fields
  • side_effects updated 2026-06-20 20:58 by etl_backfill • Backfilled from existing medication fields
  • contraindications updated 2026-06-20 20:58 by etl_backfill • Backfilled from existing medication fields
  • usage updated 2026-06-20 20:58 by etl_backfill • Backfilled from existing medication fields
  • side_effects updated 2026-06-13 11:33 by etl_backfill • Backfilled from existing medication fields
  • contraindications updated 2026-06-13 11:33 by etl_backfill • Backfilled from existing medication fields
  • usage updated 2026-06-13 11:33 by etl_backfill • Backfilled from existing medication fields
  • side_effects updated 2026-06-12 10:42 by etl_backfill • Backfilled from existing medication fields
  • contraindications updated 2026-06-12 10:42 by etl_backfill • Backfilled from existing medication fields

Usage

Monoclonal antibody used to reduce itch associated with atopic dermatitis in dogs.

Contraindications

Discuss use in dogs with a history of severe allergic reactions.

Side Effects

Injection site reactions, lethargy; generally well tolerated.

Source: FDA openFDA • Reference

Top Reported Reactions (openFDA)

De-duplicated reaction terms grouped by body system from FDA openFDA reports (not verified; does not prove causation).

Digestive
Decreased appetite (1) • Dog

Showing top 5 for Digestive.

Skin & allergy
Itching (1) • Dog Application site itching (1) • Dog

Showing top 5 for Skin & allergy.

Neurologic
Tiredness (1) • Dog

Showing top 5 for Neurologic.

Other
Pollakiuria (1) • Dog Pinnal ulcer (1) • Dog Not himself/herself (1) • Dog Low platelet count (1) • Dog Loss of hearing (1) • Dog
Show more (23)
Localised oedema (1) • Dog Injection site pain (1) • Dog Increased weight (1) • Dog Inappropriate urination (1) • Dog Inappetence (1) • Dog Impaired hearing (1) • Dog Hypocortisolaemia (1) • Dog Hearing decreased (1) • Dog Female reproductive tract disorder NOS (1) • Dog Fear/fearful (1) • Dog Elevated serum alkaline phosphatase (1) • Dog Elevated alanine aminotransferase (1) • Dog Discomfort NOS (1) • Dog Dermal mass (1) • Dog Decreased packed cell volume (1) • Dog Decreased haematocrit (1) • Dog Death (1) • Dog Deafness (1) • Dog Confusion (1) • Dog Blood in urine (1) • Dog Application site reddening (1) • Dog Application site discharge NOS (1) • Dog Abnormal adrenocorticotropic hormone (ACTH) stimulation test (1) • Dog

Showing top 5 for Other.

Data source: FDA openFDA Animal & Veterinary adverse event reports.

Adverse Event Case Summaries (openFDA)

These are individual FDA adverse event reports. They are unverified and do not prove the medication caused the reaction.

Dog, Terrier - Irish Soft-coated Wheaten, Male, 12 year, 21.319 kilogram • Drug: MSK, Unassigned, Unknown • Reactions: Death • Outcome: Died

  • Report ID: USA-USFDACVM-2025-US-074219
  • Serious AE: Yes
  • Treated For AE: No
  • Sex: Male
  • Age: 12.00 Year
  • Weight: 21.319 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Unknown
  • Form: Unassigned
Reactions Reported:
Death
Outcomes: Died

Dog, ['Schnauzer (unspecified)', 'Poodle - Miniature'], Female, 12 year, 11.3 kilogram • Drug: MSK, Injection, Unknown, Frequency: 1 per month • Reactions: Not himself/herself, Tiredness, Impaired hearing, Fear/fearful, Confusion • Outcome: Outcome Unknown

  • Report ID: USA-USFDACVM-2025-US-069675
  • Serious AE: Yes
  • Treated For AE: No
  • Sex: Female
  • Age: 12.00 Year
  • Weight: 11.300 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Unknown
  • Form: Injection
  • Frequency: 1 per month
Reactions Reported:
Not himself/herself Tiredness Impaired hearing Fear/fearful Confusion
Outcomes: Outcome Unknown

Dog, ['Shih Tzu', 'Dog (unknown)'], Male, 12 year, 10.7 kilogram • Drug: MSK, Injection, Unknown • Reactions: Dermal mass • Outcome: Recovered/Normal

  • Report ID: USA-USFDACVM-2025-US-069999
  • Serious AE: Yes
  • Treated For AE: Yes
  • Sex: Male
  • Age: 12.00 Year
  • Weight: 10.700 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Unknown
  • Form: Injection
Reactions Reported:
Dermal mass
Outcomes: Recovered/Normal

Dog, Shepherd Dog - German, Male, 9 year, 40.37 kilogram • Drug: MSK, Unassigned, Unknown • Reactions: Injection site pain, Not himself/herself, Vomiting, Wobbliness, Unexplained death • Outcome: Died

  • Report ID: USA-USFDACVM-2025-US-067552
  • Serious AE: Yes
  • Treated For AE: No
  • Sex: Male
  • Age: 9.00 Year
  • Weight: 40.370 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Unknown
  • Form: Unassigned
Reactions Reported:
Injection site pain Not himself/herself Vomiting Wobbliness Unexplained death
Outcomes: Died

Dog, Havanese, Female, 12 year, 10.5 kilogram • Drug: MSK, Injection, Unknown • Reactions: Blood in urine, Hypocortisolaemia, Abnormal adrenocorticotropic hormone (ACTH) stimulation test • Outcome: Outcome Unknown

  • Report ID: USA-USFDACVM-2025-US-069486
  • Serious AE: No
  • Treated For AE: No
  • Sex: Female
  • Age: 12.00 Year
  • Weight: 10.500 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Unknown
  • Form: Injection
Reactions Reported:
Blood in urine Hypocortisolaemia Abnormal adrenocorticotropic hormone (ACTH) stimulation test
Outcomes: Outcome Unknown

Dog, Shepherd Dog - German, Male, 43.4 kilogram • Drug: MSK, Unknown • Reactions: Decreased appetite, Tiredness (lethargy), Inappetence, Elevated alanine aminotransferase, Elevated serum alkaline phosphatase… • Outcome: Outcome Unknown

  • Report ID: USA-USFDACVM-2025-US-065104
  • Serious AE: Yes
  • Treated For AE: No
  • Sex: Male
  • Weight: 43.400 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Unknown
Reactions Reported:
Decreased appetite Tiredness (lethargy) Inappetence Elevated alanine aminotransferase Elevated serum alkaline phosphatase Decreased haematocrit Decreased packed cell volume Low platelet count Discomfort NOS Loss of hearing Localised oedema Hearing decreased
Outcomes: Outcome Unknown

Data source: FDA openFDA Animal & Veterinary adverse event reports.

Overdose Information

No approved overdose-management text is linked yet. If overdose is suspected, contact a veterinarian or emergency clinic immediately.

Storage & Handling

Refrigerate and protect from light; do not freeze.

Share Your Thoughts

Let others know your experience or advice regarding this medication.

This medication has not been reviewed by a veterinarian yet.