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Roxee Medication Guide
Medication reference facts with explicit FDA-approval, off-label, source-limited, and safety context. Roxee does not sell, prescribe, or dispense medications.
Veterinary professional?
These are the reference facts Roxee uses on browse cards and quick facts.
Sponsor, product, and application records imported from Animal Drugs @ FDA.
openFDA reaction terms and case summaries are supporting evidence, not proof of causality.
Drug type: Generic ingredient • Branded profile • FDA branded products available
Species: Both
Manufacturer: Multiple FDA labelers
Merged from the current Roxee medication system with field-level provenance, freshness, and completeness tracking.
COX-2 selective NSAID used for short-term control of postoperative pain and inflammation in cats and dogs. Species commonly shown: Both, Cat, Dog.
COX-2 selective NSAID used for short-term control of postoperative pain and inflammation in cats and dogs.
Oral, Injectable
Store at controlled room temperature (15–25°C); keep tablets in their blister pack, protected from moisture and light.
Do not use in animals with known hypersensitivity to NSAIDs, gastrointestinal ulcers, or severe renal/hepatic dysfunction. Not recommended for pregnant or lactating animals.
May cause GI upset (vomiting, diarrhea), reduced appetite; rare cases of severe kidney or GI complications have been reported.
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Used for:
For the control of postoperative pain and inflammation associated with orthopedic surgery, ovariohysterectomy and castration, in cats greaterThanEqualTo 5.5 lbs (2.5 kg) and greaterThanEqualTo 4 months of age; for up to...
Dosing note:
Exact dosing depends on your pet's species, weight, and health status. Use your veterinarian's instructions for the exact dose and schedule.
What to watch for:
When to call the vet:
What to tell or ask your vet today:
A source-aware map of what to know, what is uncertain, and what to verify with your veterinarian.
Roxee has limited cited overview evidence for Robenacoxib; use the official documents and your veterinarian's instructions for product-specific decisions.
32 tracked reaction signals; 32 reported cases; 21 serious reports; 1 species group. These are reporting and label-derived signals for interpretation with a veterinarian.
Adverse-event reports help form a watch list, but they do not prove the medication caused the reaction and they are not a risk ranking between medications.
Official labels, package inserts, and reviewed summaries carry more weight than isolated reports.
Case reports and openFDA terms are useful for pattern awareness, but they are incomplete, can include multiple exposures, and do not estimate an individual pet's probability of harm.
Unsteady walking (ataxia) (1 reports), Loss of appetite (1 reports), Bone marrow suppression (1 reports), Bloody diarrhoea (1 reports), Blood in vomit (1 reports)
Digestive (3), Skin & allergy (2), Neurologic (1), Behavior (3)
Cat (32 reports)
Domestic Shorthair (5), Cat (other) (1), Domestic Longhair (1), Russian (1). These are report metadata, not proof that a breed is at higher risk.
Verify whether Robenacoxib fits the pet's species, current diagnosis, age, weight, organ status, pregnancy/lactation status, and concurrent medications.
Separate label-backed warnings from adverse-event reports and owner observations before changing the plan.
Do not use in animals with known hypersensitivity to NSAIDs, gastrointestinal ulcers, or severe rena, Not recommended for pregnant or lactating animals, wobbly/unsteady walking, Loss of appetite, Bone marrow suppression
Repeated vomiting or diarrhea. Severe lethargy (hard to wake, very low energy). Collapse or fainting.
Review status / Updated / Sources
Review status: Clinical reviewer not listed
Updated: February 12, 2026, 7:40 PM UTC
Side effects to monitor:
Most reported reactions:
Emergency warning signs:
Source-backed clinical checkpoints for quick review.
Official label facts first, then secondary summaries. Marketing content is separated below.
Do not use in animals with known hypersensitivity to NSAIDs, gastrointestinal ulcers, or severe renal/hepatic dysfunction. Not recommended for pregnant or lactating animals.
Snapshot first, detailed rows second. This section summarizes signal data and is not a diagnosis.
Filter stored openFDA reports by pet and report attributes. Counts describe reports in this data set, not risk.
Received 2026-03-23 · MSK · MSK
Received 2026-03-23 · MSK · MSK
Received 2026-03-19 · MSK · MSK
Received 2026-03-17 · MSK · MSK
Received 2026-03-17 · MSK · MSK
Received 2026-03-16 · MSK · MSK
Received 2026-02-09 · MSK · MSK
Received 2026-02-03 · MSK · MSK
Received 2026-01-27 · MSK · MSK
Received 2026-01-19 · MSK · MSK
Received 2025-12-23 · MSK · MSK
Received 2025-12-17 · MSK · MSK
Received 2025-12-17 · MSK · MSK
Received 2025-12-16 · MSK · MSK
Received 2025-12-02 · MSK · MSK
Received 2025-12-01 · MSK · MSK
Received 2025-11-20 · MSK · MSK
Received 2025-11-14 · MSK · MSK
Received 2025-11-12 · MSK · MSK
Tap or hover a reaction to see what it means in plain language.
| Reaction | Body system | Cases | Species | Serious cases |
|---|---|---|---|---|
| Neurologic | 1 | Cat | 1 | |
| Digestive | 1 | Cat | 1 | |
| Other | 1 | Cat | 1 | |
| Digestive | 1 | Cat | 1 | |
| Digestive | 1 | Cat | 1 | |
| Other | 1 | Cat | 1 | |
| Other | 1 | Cat | 1 | |
| Other | 1 | Cat | 1 |
Species coverage: Cat (32)
| Reaction | Body system | Species | Seriousness | Frequency | Reports |
|---|---|---|---|---|---|
| Neurologic | Cat | Serious | - | 1 | |
| Digestive | Cat | Serious | - | 1 | |
| Other | Cat | Serious | - | 1 | |
| Other | Cat | Non-serious | - | 1 | |
| Digestive | Cat | Serious | - | 1 | |
| Digestive | Cat | Serious | - | 1 | |
| Other | Cat | Non-serious | - | 1 | |
| Other | Cat | Serious | - | 1 | |
| Other | Cat | Non-serious | - | 1 | |
| Other | Cat | Serious | - | 1 | |
| Other | Cat | Serious | - | 1 | |
| Behavior | Cat | Serious | - | 1 | |
| Other | Cat | Serious | - | 1 | |
| Other | Cat | Non-serious | - | 1 | |
| Other | Cat | Serious | - | 1 | |
| Skin & allergy | Cat | Non-serious | - | 1 | |
| Other | Cat | Non-serious | - | 1 | |
| Skin & allergy | Cat | Non-serious | - | 1 | |
| Other | Cat | Non-serious | - | 1 | |
| Other | Cat | Non-serious | - | 1 | |
| Behavior | Cat | Non-serious | - | 1 | |
| Other | Cat | Serious | - | 1 | |
| Other | Cat | Serious | - | 1 | |
| Other | Cat | Non-serious | - | 1 | |
| Behavior | Cat | Serious | - | 1 | |
| Other | Cat | Serious | - | 1 | |
| Other | Cat | Serious | - | 1 | |
| Other | Cat | Serious | - | 1 | |
| Other | Cat | Serious | - | 1 | |
| Other | Cat | Serious | - | 1 | |
| Other | Cat | Serious | - | 1 | |
| Other | Cat | Serious | - | 1 |
Store at controlled room temperature (15–25°C); keep tablets in their blister pack, protected from moisture and light.
The most useful source links appear first; full previews and metadata stay in the veterinary/professional layer.
Use original documents to confirm product-specific warnings, ingredients, and handling details with your veterinarian.
Full source previews and metadata remain in the veterinary/professional layer.
Official label / PI · Labeling
Official label / PI · Labeling
Official label / PI · Labeling
Official label / PI · Labeling
Official label / PI · Labeling
Official label / PI · Labeling
Official label / PI · Labeling
Official label / PI · Labeling
SPL · SPL
Rendered from Roxee's cached FDA SPL package contents for on-page reading. Use Open original for the raw FDA ZIP/XML source.
For the control of postoperative pain and inflammation associated with orthopedic surgery, ovariohysterectomy and castration, in cats greaterThanEqualTo 5.5 lbs (2.5 kg) and greaterThanEqualTo 4 months of age; for up to a maximum of 3 days.
Administer 0.45 mg/lb (1 mg/kg) orally, once daily, for a maximum of 3 days.
SPL · SPL
Rendered from Roxee's cached FDA SPL package contents for on-page reading. Use Open original for the raw FDA ZIP/XML source.
ONSIOR (robenacoxib) injection is indicated for the control of postoperative pain and inflammation associated with orthopedic surgery, ovariohysterectomy and castration in cats greaterThanEqualTo 4 months of age; for up to a maximum of 3 days.
For subcutaneous injection in cats greaterThanEqualTo 4 months of age; for up to a maximum of 3 days. To ensure accuracy of dosing, the use of a 1 mL graduated syringe is recommended. The first dose should be administered approximately 30 minutes prior to surgery, at the same time as the pre-anesthetic agents are given.
Subsequent doses can be given via subcutaneous injection, or interchanged with the oral tablet in cats greaterThanEqualTo 5.5 lbs and greaterThanEqualTo 4 months of age, for a maximum of 3 total ONSIOR doses over 3 days, not to exceed one dose per day (see Animal Safety and ONSIOR tablet product insert).
ONSIOR (robenacoxib) injection is indicated for the control of postoperative pain and inflammation associated with soft tissue surgery in dogs greaterThanEqualTo 4 months of age; for up to a maximum of 3 days.
For subcutaneous injection in dogs greaterThanEqualTo 4 months of age; for up to a maximum of 3 days. The first dose should be administered approximately 45 minutes prior to surgery, at the same time as the pre-anesthetic agents are given.
Subsequent doses can be given via subcutaneous injection, or interchanged with the oral tablet in dogs greaterThanEqualTo 5.5 lbs and greaterThanEqualTo 4 months of age, for a maximum of 3 total ONSIOR doses over 3 days, not to exceed one dose per day (see Animal Safety and ONSIOR tablet product insert). If subsequent doses are given by subcutaneous injection, different sites for each injection should be used (See Adverse Reactions).
SPL · SPL
Rendered from Roxee's cached FDA SPL package contents for on-page reading. Use Open original for the raw FDA ZIP/XML source.
Robenacoxib Injection is indicated for the control of postoperative pain and inflammation associated with soft tissue surgery in dogs greaterThanEqualTo 4 months of age; for up to a maximum of 3 days.
Administer 0.91 mg per pound (2 mg/kilogram (kg)) by subcutaneous injection, once daily, for a maximum of 3 days. After the initial subcutaneous dose, subsequent doses can be given by subcutaneous injection or as the oral tablet in dogs weighing at least 5.5 pounds (2.5 kg) and at least 4 months of age, for a maximum of 3 total doses over 3 days, not to exceed 1 dose per day.
Robenacoxib Injection is indicated for the control of postoperative pain and inflammation associated with orthopedic surgery, ovariohysterectomy and castration in cats greaterThanEqualTo 4 months of age; for up to a maximum of 3 days.
Administer 0.91 mg per pound (2 mg/kg) by subcutaneous injection, once daily, for a maximum of 3 days.
SPL · SPL
Rendered from Roxee's cached FDA SPL package contents for on-page reading. Use Open original for the raw FDA ZIP/XML source.
ONSIOR tablets are indicated for the control of postoperative pain and inflammation associated with orthopedic surgery, ovariohysterectomy and castration, in cats greaterThanEqualTo 5.5 lbs (2.5 kg) and greaterThanEqualTo 4 months of age; for up to a maximum of 3 days.
The dose of ONSIOR tablets is 0.45 mg/lb (1 mg/kg) orally once daily, for a maximum of 3 days.
SPL · SPL
Rendered from Roxee's cached FDA SPL package contents for on-page reading. Use Open original for the raw FDA ZIP/XML source.
SPL · Structured Product Label
SPL · Structured Product Label
SPL · Structured Product Label
SPL · Structured Product Label
SPL · Structured Product Label
SPL · Structured Product Label
SPL · Structured Product Label
SPL · Structured Product Label
SPL · Structured Product Label
SPL · Structured Product Label
SPL · Structured Product Label
SPL · Structured Product Label
FOI · FOI
FOI · FOI
FOI · FOI
FOI · FOI
FOI · FOI
FOI · FOI
FOI · FOI
Canonical medication sections are above. This legacy block remains available for deeper cross-reference without cluttering the primary workflow.
Quick facts and links to official labeling and safety signals.
Diagnosis-code mappings are not available for this medication yet.
Global Pet owner/Vet mode is controlled in the header. This section avoids duplicate in-page persona tabs.
Normalized identifiers (NDC/NADA/ANADA) and package metadata from regulator listings.
| Package NDC | Product NDC | Form / Route | Status |
|---|---|---|---|
| 11695-7047-1 | 11695 | - | |
| 58198-4875-1 | 58198 | - | |
| 58198-4886-1 | 58198 | - | |
| 58198-5911-0 | 58198 | - | |
| 73377-097-01 | 73377 | - | |
| 86117-080-16 | 86117 | - | |
| 86136-149-35 | 86136 | - |
Documents are tiered by source trust: Official, Clinical, Manufacturer, Marketing.
Every non-trivial field is expected to include provenance and update timestamps.
Official sponsor/proprietary-name/application-status records linked by active ingredient.
| Product | Sponsor | Application | Status | Published |
|---|---|---|---|---|
|
Robenacoxib
RX
Robenacoxib
Tablet
• Oral
|
ZyVet Animal Health, Inc. | ANADA 200-832 | Approved | Jul 23, 2026 |
|
onsior® injection
RX
Robenacoxib
Injection
• Subcutaneous
|
Elanco US Inc. | NADA 141-443 | Approved | Jun 4, 2026 |
|
Robenacoxib Injection
RX
Robenacoxib
Injectable Solution
• Subcutaneous
|
Cronus Pharma Specialities India Private Ltd. | ANADA 200-804 | Approved | Apr 1, 2026 |
|
onsior® Tablets for Cats
RX
Robenacoxib
Tablet
• Oral
|
Elanco US Inc. | NADA 141-320 | Approved | Mar 16, 2026 |
|
onsior™
RX
Robenacoxib
Tablet
• Oral
|
Elanco US Inc. | NADA 141-463 | Approved | Mar 8, 2018 |
Data source: FDA Animal Drugs @ FDA (public search export).
Extracted from FDA Animal Drugs @ FDA product labeling. Always confirm details with your veterinarian.
For the control of postoperative pain and inflammation associated with orthopedic surgery, ovariohysterectomy and castration, in cats greaterThanEqualTo 5.5 lbs (2.5 kg) and greaterThanEqualTo 4 months of age; for up to a maximum of 3 days.
Administer 0.45 mg/lb (1 mg/kg) orally, once daily, for a maximum of 3 days.
FDA page: Open in Animal Drugs @ FDA
ONSIOR (robenacoxib) injection is indicated for the control of postoperative pain and inflammation associated with orthopedic surgery, ovariohysterectomy and castration in cats greaterThanEqualTo 4 months of age; for up to a maximum of 3 days.
For subcutaneous injection in cats greaterThanEqualTo 4 months of age; for up to a maximum of 3 days. To ensure accuracy of dosing, the use of a 1 mL graduated syringe is recommended. The first dose should be administered approximately 30 minutes prior to surgery, at the same time as the pre-anesthetic agents are given.
Subsequent doses can be given via subcutaneous injection, or interchanged with the oral tablet in cats greaterThanEqualTo 5.5 lbs and greaterThanEqualTo 4 months of age, for a maximum of 3 total ONSIOR doses over 3 days, not to exceed one dose per day (see Animal Safety and ONSIOR tablet product insert).
ONSIOR (robenacoxib) injection is indicated for the control of postoperative pain and inflammation associated with soft tissue surgery in dogs greaterThanEqualTo 4 months of age; for up to a maximum of 3 days.
For subcutaneous injection in dogs greaterThanEqualTo 4 months of age; for up to a maximum of 3 days. The first dose should be administered approximately 45 minutes prior to surgery, at the same time as the pre-anesthetic agents are given.
Subsequent doses can be given via subcutaneous injection, or interchanged with the oral tablet in dogs greaterThanEqualTo 5.5 lbs and greaterThanEqualTo 4 months of age, for a maximum of 3 total ONSIOR doses over 3 days, not to exceed one dose per day (see Animal Safety and ONSIOR tablet product insert). If subsequent doses are given by subcutaneous injection, different sites for each injection should be used (See Adverse Reactions).
FDA page: Open in Animal Drugs @ FDA
Robenacoxib Injection is indicated for the control of postoperative pain and inflammation associated with soft tissue surgery in dogs greaterThanEqualTo 4 months of age; for up to a maximum of 3 days.
Administer 0.91 mg per pound (2 mg/kilogram (kg)) by subcutaneous injection, once daily, for a maximum of 3 days. After the initial subcutaneous dose, subsequent doses can be given by subcutaneous injection or as the oral tablet in dogs weighing at least 5.5 pounds (2.5 kg) and at least 4 months of age, for a maximum of 3 total doses over 3 days, not to exceed 1 dose per day.
Robenacoxib Injection is indicated for the control of postoperative pain and inflammation associated with orthopedic surgery, ovariohysterectomy and castration in cats greaterThanEqualTo 4 months of age; for up to a maximum of 3 days.
Administer 0.91 mg per pound (2 mg/kg) by subcutaneous injection, once daily, for a maximum of 3 days.
FDA page: Open in Animal Drugs @ FDA
ONSIOR tablets are indicated for the control of postoperative pain and inflammation associated with orthopedic surgery, ovariohysterectomy and castration, in cats greaterThanEqualTo 5.5 lbs (2.5 kg) and greaterThanEqualTo 4 months of age; for up to a maximum of 3 days.
The dose of ONSIOR tablets is 0.45 mg/lb (1 mg/kg) orally once daily, for a maximum of 3 days.
FDA page: Open in Animal Drugs @ FDA
FDA page: Open in Animal Drugs @ FDA
COX-2 selective NSAID used for short-term control of postoperative pain and inflammation in cats and dogs.
Source: FDA Animal Drugs @ FDA • Reference
Do not use in animals with known hypersensitivity to NSAIDs, gastrointestinal ulcers, or severe renal/hepatic dysfunction. Not recommended for pregnant or lactating animals.
May cause GI upset (vomiting, diarrhea), reduced appetite; rare cases of severe kidney or GI complications have been reported.
Source: FDA openFDA • Reference
De-duplicated reaction terms grouped by body system from FDA openFDA reports (not verified; does not prove causation).
Showing top 5 for Digestive.
Showing top 5 for Skin & allergy.
Showing top 5 for Neurologic.
Showing top 5 for Behavior.
Showing top 5 for Other.
Data source: FDA openFDA Animal & Veterinary adverse event reports.
These are individual FDA adverse event reports. They are unverified and do not prove the medication caused the reaction.
Cat, Cat (other), Male, 12.5 year, 8.278 kilogram • Drug: MSK, Unassigned, Unknown • Reactions: Weakness, Unsteady walking (ataxia), Gait abnormality, Luxation/subluxation, Joint pain… • Outcome: Ongoing
Cat, Domestic Shorthair, Female, 19.7 week, 2.22 kilogram • Drug: MSK, Injection, Subcutaneous • Reactions: Not himself/herself, Behavioral disorder (unspecified), Disorientation, Dilated pupils, Tiredness (lethargy)… • Outcome: Outcome Unknown
Cat, Domestic Longhair, Female, 14 year, 3.747 kilogram • Drug: MSK, Unassigned, Unknown • Reactions: Inappetence, Weight loss, Elevated symmetrical dimethylarginine, Elevated renal parameters, Hyperphosphataemia… • Outcome: Euthanized
Cat, Domestic Shorthair, Male, 6 year, 5.89 kilogram • Drug: MSK, Injection, Unknown • Reactions: Gastrointestinal foreign body NOS • Outcome: Ongoing
Cat, Domestic Shorthair, Male, 11 week, 1.4 kilogram • Drug: MSK, Injection, Subcutaneous, Dose: 0.10 mL per animal • Reactions: Soft stool, Bloated, Disorder of gastrointestinal flora, Vomiting, Depression… • Outcome: Recovered/Normal
Cat, Domestic Shorthair, Female, 11 year, 5.33 kilogram • Drug: MSK, Injection, Subcutaneous, Dose: 0.55 mL per animal • Reactions: Dysphoria, Behavioral disorder (unspecified), Dilated pupils, Loss of appetite, Skin and tissue infection NOS… • Outcome: Recovered/Normal
Cat, Domestic Shorthair, Female, 2 year, 4.53 kilogram • Drug: MSK, Injection, Parenteral • Reactions: Limb amputation, Injection site sarcoma, Behavioral disorder (unspecified), Tiredness (lethargy), Localised pain NOS… • Outcome: Outcome Unknown
Cat, Russian, Male, 17 week, 2.223 kilogram • Drug: MSK, Unassigned, Unknown • Reactions: Unwell, Muscle tremor, Vomiting, Not eating, Gastrointestinal foreign body NOS… • Outcome: Ongoing
Data source: FDA openFDA Animal & Veterinary adverse event reports.
Overdose may result in severe GI ulceration, vomiting (possibly with blood), or renal failure. Urgent supportive care is required.
Store at controlled room temperature (15–25°C); keep tablets in their blister pack, protected from moisture and light.
Let others know your experience or advice regarding this medication.
This medication has not been reviewed by a veterinarian yet.