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Roxee Medication Guide

Phenobarbital

Medication reference facts with explicit FDA-approval, off-label, source-limited, and safety context. Roxee does not sell, prescribe, or dispense medications.

Both Reference complete FDA data linked Rx required Tablet Genus Lifesciences Official label facts Owner quick guide first
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Data freshness

Reference facts
Reference refreshed
Aug 6, 2026, 7:47 p.m.

These are the reference facts Roxee uses on browse cards and quick facts.

FDA applications
FDA application data refreshed
Aug 6, 2026, 7:47 p.m.

Sponsor, product, and application records imported from Animal Drugs @ FDA.

Safety reports
Safety data refreshed
Aug 6, 2026, 7:49 p.m.

openFDA reaction terms and case summaries are supporting evidence, not proof of causality.

Source timing details
Source timing details
  • Reference facts: Source Roxee | Refreshed Aug 6, 2026, 7:47 PM UTC
    The reference fact projection used for browse cards and quick facts.
  • Animal Drugs @ FDA: Source FDA | Refreshed Aug 6, 2026, 7:46 PM UTC
    Applications/products are imported from FDA export data.
  • Animal Drugs @ FDA previews: Source FDA | Refreshed Feb 9, 2026, 3:05 AM UTC
    Label highlights/doc links are fetched from FDA preview endpoints.
  • Animal Drug Product Listing Directory (NDC): Source FDA | Refreshed Aug 6, 2026, 7:47 PM UTC
    Package/product NDCs from FDA’s electronic listing directory (XLS).
  • openFDA reaction terms: Source FDA openFDA | Refreshed Aug 6, 2026, 7:52 PM UTC
  • openFDA case summaries: Source FDA openFDA | Refreshed Aug 6, 2026, 7:52 PM UTC
Illustration placeholder
Phenobarbital

Phenobarbital

Drug type: Generic ingredient • Branded profile • FDA branded products available

Both Tablet Rx required 100% reference complete

Species: Both

Manufacturer: Genus Lifesciences

Medication Snapshot

Merged from the current Roxee medication system with field-level provenance, freshness, and completeness tracking.

Phenobarbital

Anti-seizure medication used for epilepsy and seizure disorders. Species commonly shown: Both, Dog.

Generic name
Phenobarbital
Brand names
FIDOQUEL™-CA1, FIDOQUEL-CA1
Manufacturer
Genus Lifesciences
Species
Both, Dog
Dosage forms
Tablet
Prescription
Prescription required
Completeness
100%
Validation
Complete
Brand names
FIDOQUEL™-CA1 FIDOQUEL-CA1
Dosage forms
Tablet

Indications / Uses

Anti-seizure medication used for epilepsy and seizure disorders.

Administration / How To Give

Oral

Storage

Store at room temperature; keep secured.

Warnings / Contraindications

Use caution with liver disease.

  • Use caution with liver disease.

Side Effects

Sedation, increased thirst/urination, increased appetite. Long-term: liver enzyme changes.

FAQ

Both, Dog

Yes. Roxee shows this as prescription-only.

Tablet

Store at room temperature; keep secured.

Related Medications

Cyclosporine Same category: Allergies / Itching Diphenhydramine Same category: Allergies / Itching Lokivetmab Same category: Allergies / Itching Oclacitinib Same category: Allergies / Itching Oclacitinib Maleate Same category: Allergies / Itching Prednisone Same category: Allergies / Itching

Related Conditions

Seizures (idiopathic/structural)

Source Transparency

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Pet Owner Quick Guide

Start here first for the safest next-step summary before the deeper medication detail.

Used for:

Conditionally approved for the control of seizures associated with idiopathic epilepsy in dogs.

Dosing note:

Exact dosing depends on your pet's species, weight, and health status. Use your veterinarian's instructions for the exact dose and schedule.

What to watch for:

  • Use caution with liver disease
  • wobbly/unsteady walking (1 reports)
  • Falling (1 reports)
  • Eyes rolling back (1 reports)

When to call the vet:

  • Repeated vomiting or diarrhea.
  • Severe lethargy (hard to wake, very low energy).
  • Collapse or fainting.
  • Trouble breathing.
  • Facial swelling or hives.
  • Blood in vomit or stool.

What to tell or ask your vet today:

  • Is this medicine the right fit for my pet’s current symptoms?
  • Which warning signs mean I should call back right away?
  • How should I handle missed doses or refusal to take the medicine?

Next actions

Talk to a Vet / Find a Vet Near You Save to pet meds Share page Review report evidence
Research brief

Medication Research Insights

A source-aware map of what to know, what is uncertain, and what to verify with your veterinarian.

Source Backed Signals

What to know

Evidence-backed context Limited

Roxee has limited cited overview evidence for Phenobarbital; use the official documents and your veterinarian's instructions for product-specific decisions.

Source: openFDA case USA-USFDACVM-2026-US-003253
Safety signal coverage Reported signals

32 tracked reaction signals; 32 reported cases; 18 serious reports; 2 species groups. These are reporting and label-derived signals for interpretation with a veterinarian.

Source: openFDA case USA-USFDACVM-2026-US-003253
Interpretation guardrail Not causation

Adverse-event reports help form a watch list, but they do not prove the medication caused the reaction and they are not a risk ranking between medications.

Evidence tension

Stronger signal Label / review

Official labels, package inserts, and reviewed summaries carry more weight than isolated reports.

Source: openFDA case USA-USFDACVM-2026-US-003253
Weaker signal Reported data

Case reports and openFDA terms are useful for pattern awareness, but they are incomplete, can include multiple exposures, and do not estimate an individual pet's probability of harm.

Reaction signal map

Most reported reactions Top terms

Unsteady walking (ataxia) (1 reports), Falling (1 reports), Eyes rolling back (1 reports), Eosinopenia (1 reports), Elevated symmetrical dimethylarginine (1 reports)

Body systems represented Signal grouping

Digestive (3), Neurologic (1), Behavior (2), Other (26)

Explore supporting adverse reports

Species and breed lens

Species represented in reports Species lens

Cat (21 reports), Dog (11 reports)

Breed metadata in reports Metadata only

Domestic Shorthair (3), Shepherd Dog - German (1), ['Retriever - Golden', 'Dog (unknown)'] (1), Dog (unknown) (1). These are report metadata, not proof that a breed is at higher risk.

What your vet may verify

Fit for this patient Vet check

Verify whether Phenobarbital fits the pet's species, current diagnosis, age, weight, organ status, pregnancy/lactation status, and concurrent medications.

Evidence limitations Evidence review

Separate label-backed warnings from adverse-event reports and owner observations before changing the plan.

What to watch next

Watch list Owner-safe

Use caution with liver disease, wobbly/unsteady walking, Falling, Eyes rolling back

Call sooner if Escalation

Repeated vomiting or diarrhea. Severe lethargy (hard to wake, very low energy). Collapse or fainting.

Bottom line: Use this Phenobarbital brief as a structured watch list and source map, not as a reason to start, stop, or change treatment without your veterinarian.
Vet source depth
  1. openFDA case USA-USFDACVM-2026-US-003253 · adverse_reaction · adverse reactions
  2. Contraindication source · fda_animal_drugs · warnings contraindications
  3. FDA application profile · official_label · quick facts
  4. Medication usage source · fda_animal_drugs · quick facts
  5. FOI · document · documents
  6. SPL · document · documents
  7. Structured Product Label · document · documents
  8. Structured Product Label · document · documents

Evidence

Review status / Updated / Sources

Review status: Clinical reviewer not listed

Updated: February 12, 2026, 7:40 PM UTC

Sources:
Safety & side effects

Side effects to monitor:

  • Use caution with liver disease
  • wobbly/unsteady walking
  • Falling
  • Eyes rolling back

Most reported reactions:

  • Unsteady walking (ataxia) (1 reports)
  • Falling (1 reports)
  • Eyes rolling back (1 reports)
Explore reported case details

Emergency warning signs:

  • Repeated vomiting or diarrhea.
  • Severe lethargy (hard to wake, very low energy).
  • Collapse or fainting.
  • Trouble breathing.
Talk to a Vet / Find a Vet Near You Start Symptom Intake

Vet Fast Scan

Source-backed clinical checkpoints for quick review.

FDA-labeled species
Dog
Indication / use
Conditionally approved for the control of seizures associated with idiopathic epilepsy in dogs.
Form / route / dose
Form: Tablet
Route: Oral
Confirm product label and patient-specific plan.
Warnings
  • High: Use caution with liver disease.
Adverse-event caveat
openFDA adverse-event cases are reported signals. They are not verified, do not prove causation, and do not estimate a pet's individual risk.
Source docs

Quick Facts

Official label facts first, then secondary summaries. Marketing content is separated below.

Species: Both
Manufacturer: Genus Lifesciences
Form: Tablet
Identifiers:
NADA: 141578 NDC Package: 64950-541-01 NDC Package: 64950-541-10 NDC Package: 64950-542-01 NDC Package: 64950-542-10 NDC Package: 64950-543-01 NDC Package: 64950-543-10 NDC Package: 64950-544-01 NDC Package: 64950-544-10 NDC Package: 64950-560-01 NDC Package: 64950-560-10 NDC Package: 64950-561-01 NDC Package: 64950-561-10 NDC Package: 64950-562-01 NDC Package: 64950-562-10 NDC Package: 64950-563-01 NDC Package: 64950-563-10 NDC Product: 64950
Source metadata:

Warnings / Contraindications

Use caution with liver disease.

  • High: Use caution with liver disease.
Source metadata:

Adverse Reactions

Snapshot first, detailed rows second. This section summarizes signal data and is not a diagnosis.

Reported case explorer

Filter stored openFDA reports by pet and report attributes. Counts describe reports in this data set, not risk.

Clear filters
openFDA adverse-event cases are reported signals. They are not verified, do not prove causation, and do not estimate a pet's individual risk.
Stored reports
18
Matching reports
2
Active filters
1
Selected filters
Reaction: Aggression Clear
Reset
Drill into common report signals
Seizure NOS (9) Anaemia NOS (3) Acting tense (2) Aggression (2) Neurologic (12) Other (10) Effectiveness (3) Skin & allergy (3)
Showing up to 50 matching reports.

USA-USFDACVM-2026-US-008917

Received 2026-01-29 · MSK · MSK

Serious
Species
Cat
Breed
Domestic Shorthair
Size / weight
10-24 lb (6.53 Kilogram)
Age
1-3 years (1.33 Year)
Sex
Male Neutered
Region
USA
Reactions
PtyalismTremorSeizure NOSAggressionLeukocytosis NOSNeutrophiliaEosinopeniaHypernatraemiaElevated cholesterol (total)Eyes rolling backHyperactivityElevated haematocritDisorientationUrinary tract obstruction/blockageAnaemia NOSOther abnormal test result NOSMydriasisActing tenseMental confusionTwitchingBradycardiaDecreased heart rateBehavioural disorder NOSHaematuriaProteinuria
Body systems
OtherNeurologicBehaviorSkin & allergy
Outcomes
Outcome Unknown

USA-USFDACVM-2026-US-003253

Received 2026-01-16 · MSK · MSK

Serious
Species
Cat
Breed
Domestic Shorthair
Size / weight
10-24 lb (6.53 Kilogram)
Age
1-3 years (1.33 Year)
Sex
Male Neutered
Region
USA
Reactions
PtyalismTremorSeizure NOSAggressionLeukocytosis NOSNeutrophiliaEosinopeniaHypernatraemiaElevated cholesterol (total)Eyes rolling backHyperactivityElevated haematocritDisorientationUrinary tract obstruction/blockageAnaemia NOSOther abnormal test result NOSMydriasisActing tenseMental confusionTwitchingBradycardiaDecreased heart rateBehavioural disorder NOSHaematuriaProteinuria
Body systems
OtherNeurologicBehaviorSkin & allergy
Outcomes
Outcome Unknown

Tap or hover a reaction to see what it means in plain language.

Tracked signals
32
Reported cases
32
Serious reports
18
Species represented
2
Grouped by Body System
Digestive (3) · Vomiting, Diarrhea, Blood in vomit Neurologic (1) · Unsteady walking (ataxia) Behavior (2) · Behavioral disorder (unspecified), Aggression Other (26) · Falling, Eyes rolling back, Excessive thirst
Most Reported Reactions
Reaction Body system Cases Species Serious cases
Neurologic 1 Cat 1
Other 1 Dog 1
Other 1 Cat 1
Other 1 Cat 1
Other 1 Cat 1
Other 1 Cat 1
Other 1 Cat 1
Other 1 Cat 1

Species coverage: Cat (21) Dog (11)

View detailed reaction table
Reaction Body system Species Seriousness Frequency Reports
Digestive Cat Non-serious - 1
Neurologic Cat Serious - 1
Other Dog Serious - 1
Other Cat Serious - 1
Other Dog Non-serious - 1
Other Cat Serious - 1
Other Cat Serious - 1
Other Dog Non-serious - 1
Other Cat Serious - 1
Other Cat Serious - 1
Other Cat Non-serious - 1
Other Dog Non-serious - 1
Other Cat Serious - 1
Other Dog Non-serious - 1
Other Dog Non-serious - 1
Digestive Cat Serious - 1
Other Dog Non-serious - 1
Other Cat Serious - 1
Other Cat Serious - 1
Other Dog Non-serious - 1
Other Dog Non-serious - 1
Other Cat Serious - 1
Other Dog Non-serious - 1
Other Dog Non-serious - 1
Other Cat Serious - 1
Digestive Cat Non-serious - 1
Behavior Cat Serious - 1
Other Cat Non-serious - 1
Other Cat Serious - 1
Other Cat Serious - 1
Behavior Cat Serious - 1
Other Cat Serious - 1
Source metadata:

Storage & Handling

Store at room temperature; keep secured.

Source Documents

The most useful source links appear first; full previews and metadata stay in the veterinary/professional layer.

Use original documents to confirm product-specific warnings, ingredients, and handling details with your veterinarian.

FIDOQUEL™-CA1 SPL · SPL FIDOQUEL-CA1 SPL SPL · Structured Product Label FIDOQUEL-CA1 SPL SPL · Structured Product Label

Full source previews and metadata remain in the veterinary/professional layer.

Owner handouts

0
No owner handouts linked yet.

Official label / PI

0
No official label or package insert links yet.

SPL

3

FOI

1

FIDOQUEL™-CA1

SPL · SPL

Open original
FDA Structured Product Label

FIDOQUEL™-CA1

Rendered from Roxee's cached FDA SPL package contents for on-page reading. Use Open original for the raw FDA ZIP/XML source.

Sponsor
Genus Lifesciences Inc.
C
141-578
Status
RX
Form
Tablet
Route
Oral
Species
Dog
Composition / specifications
15, 16.2, 30, 32.4, 60, 64.8, 97.2, or 100 mg per tablet

Dogs

Indication

Conditionally approved for the control of seizures associated with idiopathic epilepsy in dogs.

Dosage

Administer phenobarbital as tablets given orally twice a day at the minimum dosage of 2.5 mg per kilogram of body weight (mg/kg) and may be titrated to effect to a maximum dosage of 5 mg/kg. The dosage of phenobarbital tablets should be adjusted based on monitoring the clinical response of the individual patient.

FIDOQUEL-CA1 SPL

SPL · Structured Product Label

Open original
FDA Structured Product Label XML for FIDOQUEL-CA1. Use the source link for the full official labeling record.

FIDOQUEL-CA1 SPL

SPL · Structured Product Label

Open original
FDA Structured Product Label XML for FIDOQUEL-CA1. Use the source link for the full official labeling record.

FOI Summary 141-578 Approved September 6, 2023.pdf

FOI · FOI

Open original
Source metadata:
Veterinary reference (advanced)

Canonical medication sections are above. This legacy block remains available for deeper cross-reference without cluttering the primary workflow.

At a Glance

Quick facts and links to official labeling and safety signals.

Data freshness
  • Reference facts: Source Roxee | Refreshed Aug 6, 2026, 7:47 PM UTC
    The reference fact projection used for browse cards and quick facts.
  • Animal Drugs @ FDA: Source FDA | Refreshed Aug 6, 2026, 7:46 PM UTC
    Applications/products are imported from FDA export data.
  • Animal Drugs @ FDA previews: Source FDA | Refreshed Feb 9, 2026, 3:05 AM UTC
    Label highlights/doc links are fetched from FDA preview endpoints.
  • Animal Drug Product Listing Directory (NDC): Source FDA | Refreshed Aug 6, 2026, 7:47 PM UTC
    Package/product NDCs from FDA’s electronic listing directory (XLS).
  • openFDA reaction terms: Source FDA openFDA | Refreshed Aug 6, 2026, 7:52 PM UTC
  • openFDA case summaries: Source FDA openFDA | Refreshed Aug 6, 2026, 7:52 PM UTC
Official (FDA)
Identity: Generic ingredient • FDA branded products available
Official FDA brands: FIDOQUEL-CA1
Manufacturer mapping: Genus Lifesciences
Case-reported brands (openFDA): MSK
Catalog species: Both • FDA-labeled species: Dog
Rx/OTC: RX
Form/route: Tablet • Oral
Applications: C 141-578
NDC: Packages 64950-541-01 64950-541-10 64950-542-01 64950-542-10 64950-543-01 64950-543-10 • Products 64950
Documents: 1 (FOI: 1) • SPL: 1 • Label highlights • Official documents
Safety (openFDA)
Top reactions: Dog 20 • Cat 50 • View
Case summaries: 18 (showing 8) • View
openFDA reports are unverified and do not prove causation.
Explore
Related conditions: Seizures (idiopathic/structural)
Linked using: Fda_Label (0.95)
Diagnosis Codes

Diagnosis-code mappings are not available for this medication yet.

Counseling and Monitoring Highlights

Global Pet owner/Vet mode is controlled in the header. This section avoids duplicate in-page persona tabs.

Owner-facing counseling points
  • Use caution with liver disease. (Contraindication, High)
Top reaction signals
Unsteady walking (ataxia) (1) Falling (1) Eyes rolling back (1) Eosinopenia (1) Elevated symmetrical dimethylarginine (1) Elevated haematocrit (1) Elevated cholesterol (1) Disorientation (1)

Identifiers & Packages

Normalized identifiers (NDC/NADA/ANADA) and package metadata from regulator listings.

Identifiers
NADA: 141578 NDC Package: 64950-541-01 NDC Package: 64950-541-10 NDC Package: 64950-542-01 NDC Package: 64950-542-10 NDC Package: 64950-543-01 NDC Package: 64950-543-10 NDC Package: 64950-544-01 NDC Package: 64950-544-10 NDC Package: 64950-560-01 NDC Package: 64950-560-10 NDC Package: 64950-561-01 NDC Package: 64950-561-10 NDC Package: 64950-562-01 NDC Package: 64950-562-10 NDC Package: 64950-563-01 NDC Package: 64950-563-10 NDC Product: 64950
Package NDC Product NDC Form / Route Status
64950-541-01 64950 -
64950-541-10 64950 -
64950-542-01 64950 -
64950-542-10 64950 -
64950-543-01 64950 -
64950-543-10 64950 -
64950-544-01 64950 -
64950-544-10 64950 -
64950-560-01 64950 -
64950-560-10 64950 -
64950-561-01 64950 -
64950-561-10 64950 -
64950-562-01 64950 -
64950-562-10 64950 -
64950-563-01 64950 -
64950-563-10 64950 -

Enriched Documents

Documents are tiered by source trust: Official, Clinical, Manufacturer, Marketing.

  • FIDOQUEL-CA1 SPL • Structured Product Label • Official
    FDA Structured Product Label from the electronic animal drug product listing directory.
  • FIDOQUEL-CA1 SPL • Structured Product Label • Official
    FDA Structured Product Label from the electronic animal drug product listing directory.
  • FOI Summary 141-578 Approved September 6, 2023.pdf • FOI summary • Official • June 3, 2024
    FDA FOI summary for application 141578

Data Sources & Change Log

Every non-trivial field is expected to include provenance and update timestamps.

Official 119 Clinical 4 Manufacturer 0 Marketing 0
Current Field Facts
  • side_effects: Sedation, increased thirst/urination, increased appetite. Long-term: liver enzyme changes. (Clinical, 2026-04-11)
  • storage_handling: Store at room temperature; keep secured. (Clinical, 2026-04-12)
  • storage_handling: Store at room temperature; keep secured. (Clinical, 2026-04-11)
  • storage_handling: Store at room temperature; keep secured. (Clinical, 2026-02-12)
  • contraindications: Use caution with liver disease. (Official, 2026-04-12)
  • contraindications: Use caution with liver disease. (Official, 2026-04-11)
  • contraindications: Use caution with liver disease. (Official, 2026-02-12)
  • indications: Conditionally approved for the control of seizures associated with idiopathic epilepsy in dogs (Official, 2026-08-06)
  • indications: Conditionally approved for the control of seizures associated with idiopathic epilepsy in dogs (Official, 2026-08-05)
  • indications: Conditionally approved for the control of seizures associated with idiopathic epilepsy in dogs (Official, 2026-08-04)
  • indications: Conditionally approved for the control of seizures associated with idiopathic epilepsy in dogs (Official, 2026-08-03)
  • indications: Conditionally approved for the control of seizures associated with idiopathic epilepsy in dogs (Official, 2026-08-02)
  • indications: Conditionally approved for the control of seizures associated with idiopathic epilepsy in dogs (Official, 2026-08-01)
  • indications: Conditionally approved for the control of seizures associated with idiopathic epilepsy in dogs (Official, 2026-07-31)
  • indications: Conditionally approved for the control of seizures associated with idiopathic epilepsy in dogs (Official, 2026-07-30)
  • indications: Conditionally approved for the control of seizures associated with idiopathic epilepsy in dogs (Official, 2026-07-29)
  • indications: Conditionally approved for the control of seizures associated with idiopathic epilepsy in dogs (Official, 2026-07-28)
  • indications: Conditionally approved for the control of seizures associated with idiopathic epilepsy in dogs (Official, 2026-07-27)
  • indications: Conditionally approved for the control of seizures associated with idiopathic epilepsy in dogs (Official, 2026-07-26)
  • indications: Conditionally approved for the control of seizures associated with idiopathic epilepsy in dogs (Official, 2026-07-25)
Recent Revisions
  • side_effects updated 2026-04-12 10:05 by etl_backfill • Backfilled from existing medication fields
  • contraindications updated 2026-04-12 10:05 by etl_backfill • Backfilled from existing medication fields
  • usage updated 2026-04-12 10:05 by etl_backfill • Backfilled from existing medication fields
  • side_effects updated 2026-04-11 10:05 by etl_backfill • Backfilled from existing medication fields
  • contraindications updated 2026-04-11 10:05 by etl_backfill • Backfilled from existing medication fields
  • usage updated 2026-04-11 10:05 by etl_backfill • Backfilled from existing medication fields
  • side_effects updated 2026-02-12 19:40 by etl_backfill • Backfilled from existing medication fields
  • contraindications updated 2026-02-12 19:40 by etl_backfill • Backfilled from existing medication fields
  • usage updated 2026-02-12 19:40 by etl_backfill • Backfilled from existing medication fields

FDA Products & Applications (Animal Drugs @ FDA)

Official sponsor/proprietary-name/application-status records linked by active ingredient.

Product Sponsor Application Status Published
FIDOQUEL™-CA1
RX
Phenobarbital
Tablet • Oral
Label highlights
Official documents
Genus Lifesciences Inc. C 141-578 Approved Jun 3, 2024

Data source: FDA Animal Drugs @ FDA (public search export).

What It's For (FDA Label Highlights)

Extracted from FDA Animal Drugs @ FDA product labeling. Always confirm details with your veterinarian.

Species: Dog
Composition / specifications
15, 16.2, 30, 32.4, 60, 64.8, 97.2, or 100 mg per tablet
Dogs
Indication

Conditionally approved for the control of seizures associated with idiopathic epilepsy in dogs.

Dosage

Administer phenobarbital as tablets given orally twice a day at the minimum dosage of 2.5 mg per kilogram of body weight (mg/kg) and may be titrated to effect to a maximum dosage of 5 mg/kg. The dosage of phenobarbital tablets should be adjusted based on monitoring the clinical response of the individual patient.

Limitations

FDA page: Open in Animal Drugs @ FDA

Usage

Anti-seizure medication used for epilepsy and seizure disorders.

Source: FDA Animal Drugs @ FDA • Reference

Contraindications

Use caution with liver disease.

Side Effects

Sedation, increased thirst/urination, increased appetite. Long-term: liver enzyme changes.

Source: FDA openFDA • Reference

Top Reported Reactions (openFDA)

De-duplicated reaction terms grouped by body system from FDA openFDA reports (not verified; does not prove causation).

Digestive
Vomiting (1) • Cat Diarrhea (1) • Cat Blood in vomit (1) • Cat

Showing top 5 for Digestive.

Neurologic
Unsteady walking (1) • Cat

Showing top 5 for Neurologic.

Behavior
Behavioral disorder (1) • Cat Aggression (1) • Cat

Showing top 5 for Behavior.

Other
Falling (1) • Dog Eyes rolling back (1) • Cat Excessive thirst (1) • Dog Eosinopenia (1) • Cat Elevated symmetrical dimethylarginine (1) • Cat
Show more (21)
Elevated serum alkaline phosphatase (1) • Dog Elevated haematocrit (1) • Cat Elevated cholesterol (1) • Cat Elevated alanine aminotransferase (1) • Cat Drooping eyelid (1) • Dog Disorientation (1) • Cat Difficulty to rise (1) • Dog Difficulty standing (1) • Dog Decreased red blood cell count (1) • Dog Decreased packed cell volume (1) • Cat Decreased heart rate (1) • Cat Decreased haemoglobin (1) • Dog Decreased haematocrit (1) • Dog Cyst NOS (1) • Cat Cough (1) • Dog Collapse NOS (1) • Dog Bradycardia (1) • Cat Arthritis (1) • Cat Aortic mineralisation (1) • Cat Anaemia NOS (1) • Cat Acting tense (1) • Cat

Showing top 5 for Other.

Data source: FDA openFDA Animal & Veterinary adverse event reports.

Adverse Event Case Summaries (openFDA)

These are individual FDA adverse event reports. They are unverified and do not prove the medication caused the reaction.

Dog, Shepherd Dog - German, Male, 9 year, 43.318 kilogram • Drug: MSK, Unassigned, Oral • Reactions: Lack of efficacy (ectoparasite) - flea, Tiredness (lethargy), Unable to walk, Falling, Grand mal seizure • Outcome: Ongoing

  • Report ID: USA-USFDACVM-2026-US-014451
  • Serious AE: Yes
  • Treated For AE: Yes
  • Sex: Male
  • Age: 9.00 Year
  • Weight: 43.318 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Oral
  • Form: Unassigned
Reactions Reported:
Lack of efficacy (ectoparasite) - flea Tiredness (lethargy) Unable to walk Falling Grand mal seizure
Outcomes: Ongoing

Dog, ['Retriever - Golden', 'Dog (unknown)'], Male, 13 year, 26.036 kilogram • Drug: MSK, Unassigned, Unknown • Reactions: Partial lack of efficacy • Outcome: Ongoing

  • Report ID: USA-USFDACVM-2026-US-012643
  • Serious AE: No
  • Treated For AE: No
  • Sex: Male
  • Age: 13.00 Year
  • Weight: 26.036 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Unknown
  • Form: Unassigned
Reactions Reported:
Partial lack of efficacy
Outcomes: Ongoing

Dog, Dog (unknown), Male • Drug: MSK, Unknown • Reactions: Nausea, Difficulty to rise, Difficulty standing, Collapse NOS, Limb weakness… • Outcome: Outcome Unknown

  • Report ID: USA-USFDACVM-2026-US-018276
  • Serious AE: No
  • Treated For AE: No
  • Sex: Male
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Unknown
Reactions Reported:
Nausea Difficulty to rise Difficulty standing Collapse NOS Limb weakness Tiredness Sleepiness - systemic disorder
Outcomes: Outcome Unknown

Dog, Retriever - Labrador, Male, 3.5 year, 29.48 kilogram • Drug: MSK, Unknown • Reactions: Seizure NOS • Outcome: Recovered/Normal

  • Report ID: USA-USFDACVM-2026-US-011005
  • Serious AE: Yes
  • Treated For AE: No
  • Sex: Male
  • Age: 3.50 Year
  • Weight: 29.480 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Unknown
Reactions Reported:
Seizure NOS
Outcomes: Recovered/Normal

Dog, Spaniel - King Charles Cavalier, Female, 7.6 year, 13.15 kilogram • Drug: MSK, Unassigned, Oral, Dose: 32.40 Milligram per animal • Reactions: Excessive thirst, Cough, Swallowing difficult, Oral cavity disorder NOS, Drooping eyelid • Outcome: Ongoing

  • Report ID: USA-USFDACVM-2026-US-011498
  • Serious AE: No
  • Treated For AE: No
  • Sex: Female
  • Age: 7.60 Year
  • Weight: 13.150 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Oral
  • Form: Unassigned
  • Dose: 32.40 Milligram per animal
Reactions Reported:
Excessive thirst Cough Swallowing difficult Oral cavity disorder NOS Drooping eyelid
Outcomes: Ongoing

Cat, Domestic Shorthair, Male, 17 year, 5.806 kilogram • Drug: MSK, Unassigned, Unknown • Reactions: Anaemia NOS, Hypercalcaemia, Elevated symmetrical dimethylarginine, Seizure NOS, Lack of efficacy - NOS… • Outcome: Outcome Unknown

  • Report ID: USA-USFDACVM-2026-US-010442
  • Serious AE: Yes
  • Treated For AE: Yes
  • Sex: Male
  • Age: 17.00 Year
  • Weight: 5.806 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Unknown
  • Form: Unassigned
Reactions Reported:
Anaemia NOS Hypercalcaemia Elevated symmetrical dimethylarginine Seizure NOS Lack of efficacy - NOS Intentional misuse
Outcomes: Outcome Unknown

Cat, Domestic Shorthair, Male, 18 year, 5.67 kilogram • Drug: MSK, Unassigned, Oral, Dose: 7.50 Milligram per animal, Frequency: 12 per hour • Reactions: Seizure NOS, Unsteady walking (ataxia) • Outcome: Ongoing

  • Report ID: USA-USFDACVM-2026-US-010180
  • Serious AE: Yes
  • Treated For AE: Yes
  • Sex: Male
  • Age: 18.00 Year
  • Weight: 5.670 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Oral
  • Form: Unassigned
  • Dose: 7.50 Milligram per animal
  • Frequency: 12 per hour
Reactions Reported:
Seizure NOS Unsteady walking (ataxia)
Outcomes: Ongoing

Cat, Domestic Shorthair, Male, 14 year, 5.443 kilogram • Drug: MSK, Unassigned, Unknown • Reactions: Seizure NOS, Unsteady walking (ataxia) • Outcome: Ongoing

  • Report ID: USA-USFDACVM-2026-US-009224
  • Serious AE: Yes
  • Treated For AE: Yes
  • Sex: Male
  • Age: 14.00 Year
  • Weight: 5.443 Kilogram
  • Case-reported brand: MSK
  • Case-reported manufacturer: MSK
  • Route: Unknown
  • Form: Unassigned
Reactions Reported:
Seizure NOS Unsteady walking (ataxia)
Outcomes: Ongoing

Data source: FDA openFDA Animal & Veterinary adverse event reports.

Overdose Information

No approved overdose-management text is linked yet. If overdose is suspected, contact a veterinarian or emergency clinic immediately.

Storage & Handling

Store at room temperature; keep secured.

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